. 2012 Nov; 18(41):5848-61.
doi: 10.3748/wjg.v18.i41.5848.

Changes of the cytokine profile in inflammatory bowel diseases

Györgyi Műzes 1 Béla Molnár  Zsolt Tulassay  Ferenc Sipos  
  • PMID: 23139600
  •     153 References
  •     85 citations


Cytokines are indispensable signals of the mucosa-associated immune system for maintaining normal gut homeostasis. An imbalance of their profile in favour of inflammation initiation may lead to disease states, such as that is observed in inflammatory bowel diseases (IBD). Although Crohn's disease (CD) is often described as a prototype of T-helper 1-type diseases, and ulcerative colitis (UC) is traditionally viewed as a T-helper 2-mediated condition, the classic paradigm, which categorises cytokines into pro- and anti-inflammatory groups, has recently been changed. The inflammation regulatory pathways may not be mutually exclusive as individual cytokines can have diverse and even opposing functions in various clinical and immunological settings. None the less there are many common immunological responses in IBD that are mediated by cytokines. Although they regulate and influence the development, course and recurrence of the inflammatory process, the concrete pathogenic role of these small signaling molecules is sometimes not unambiguous in the subtypes of the disease. Our aim is to review the current information about pro- and anti-inflammatory effects of traditionally studied and recently discovered cytokines in the pathogenesis of UC and CD. The better understanding of their production and functional activity may lead to the development of new therapeutic modalities.

Keywords: Crohn’s disease; Interleukin-25; Interleukin-33; Interleukin-35; Interleukin-4; Interleukin-8; Tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor-like factor; Ulcerative colitis.

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The Proteolytic Fraction From Vasconcellea cundinamarcensis Latex Displays Anti-Inflammatory Effect in A Mouse Model of Acute TNBS-Induced Colitis.
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Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides.
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Curcumin and resveratrol suppress dextran sulfate sodium‑induced colitis in mice.
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Pro-Inflammatory Effects of NX-3 Toxin Are Comparable to Deoxynivalenol and not Modulated by the Co-Occurring Pro-Oxidant Aurofusarin.
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Potent Inhibitory Effect of BJ-3105, a 6-Alkoxypyridin-3-ol Derivative, on Murine Colitis Is Mediated by Activating AMPK and Inhibiting NOX.
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Colonic mucosal and cytobrush sample cytokine mRNA expression in canine inflammatory bowel disease and their correlation with disease activity, endoscopic and histopathologic score.
Alexandros O Konstantinidis, Katerina K Adamama-Moraitou, +6 authors, Timoleon S Rallis.
PLoS One, 2021 Jan 21; 16(1). PMID: 33471872    Free PMC article.
Intestinal Regulatory T Cells.
Vanessa R Figliuolo da Paz, Deepa R Jamwal, Pawel R Kiela.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523448
The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions.
Marianne R Spalinger, Anica Sayoc-Becerra, +7 authors, Declan F McCole.
J Crohns Colitis, 2020 Sep 11; 15(3). PMID: 32909045    Free PMC article.
Anti-tumor necrosis factor-induced lupus in patients with inflammatory bowel disease: a hospital-based cohort study from Korea.
Su Jin Choi, Soo Min Ahn, +7 authors, Yong-Gil Kim.
Therap Adv Gastroenterol, 2021 Mar 23; 14. PMID: 33747126    Free PMC article.
Is LRRK2 the missing link between inflammatory bowel disease and Parkinson's disease?
Mary K Herrick, Malú G Tansey.
NPJ Parkinsons Dis, 2021 Mar 23; 7(1). PMID: 33750819    Free PMC article.
Intestinal eosinophils: multifaceted roles in tissue homeostasis and disease.
G Coakley, H Wang, N L Harris.
Semin Immunopathol, 2021 Mar 28; 43(3). PMID: 33772336
Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors.
Ana Luisa Perdigoto, Thuy Tran, +8 authors, Harriet M Kluger.
Clin Oncol Case Rep, 2021 Mar 30; 3(5). PMID: 33778814    Free PMC article.
Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel Disease.
Eirini Giannoudaki, Siobhan Gargan, +2 authors, Patrick T Walsh.
Front Pediatr, 2021 Apr 06; 9. PMID: 33816403    Free PMC article.
Chrysophanol Attenuates Manifestations of Immune Bowel Diseases by Regulation of Colorectal Cells and T Cells Activation In Vivo.
Hyun-Su Lee, Gil-Saeng Jeong.
Molecules, 2021 Apr 04; 26(6). PMID: 33802855    Free PMC article.
Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.
Matej Fabisik, Jolana Tureckova, +11 authors, Tomas Brdicka.
Front Immunol, 2021 May 15; 12. PMID: 33986741    Free PMC article.
Systems biology approach highlights mechanistic differences between Crohn's disease and ulcerative colitis.
Pedro A Ruiz Castro, Hasmik Yepiskoposyan, +6 authors, Marja Talikka.
Sci Rep, 2021 Jun 03; 11(1). PMID: 34075172    Free PMC article.
Vaccines in Children with Inflammatory Bowel Disease: Brief Review.
Susanna Esposito, Giulia Antoniol, +6 authors, Nicola Principi.
Vaccines (Basel), 2021 Jun 03; 9(5). PMID: 34064576    Free PMC article.
Crohn's Disease Is Associated With Activation of Circulating Innate Lymphoid Cells.
Luca Mazzurana, Ferdinando Bonfiglio, +3 authors, Jenny Mjösberg.
Inflamm Bowel Dis, 2020 Dec 10; 27(7). PMID: 33295628    Free PMC article.
Aucuboside Inhibits the Generation of Th17 Cells in Mice Colitis.
Chenxue Mei, Xiao Wang, +6 authors, Yuanyuan Wang.
Front Pharmacol, 2021 Aug 03; 12. PMID: 34335262    Free PMC article.
Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice.
Shijia Pan, Fan Hong, +5 authors, Yonggong Zhai.
Pharmaceuticals (Basel), 2021 Aug 29; 14(8). PMID: 34451919    Free PMC article.
Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis.
Ju Hwan Kim, Chang Yell Shin, +4 authors, Hak Rim Kim.
Korean J Physiol Pharmacol, 2021 Aug 28; 25(5). PMID: 34448461    Free PMC article.
Specific Secondary Bile Acids Control Chicken Necrotic Enteritis.
Mohit Bansal, Tahrir Alenezi, +7 authors, Xiaolun Sun.
Pathogens, 2021 Aug 29; 10(8). PMID: 34451506    Free PMC article.
Cascade of immune mechanism and consequences of inflammatory disorders.
K B Megha, X Joseph, V Akhil, P V Mohanan.
Phytomedicine, 2021 Sep 14; 91. PMID: 34511264    Free PMC article.
Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway.
Liang Wang, Yuntao Feng, +7 authors, Jingyu Wang.
Front Pharmacol, 2021 Oct 02; 12. PMID: 34594215    Free PMC article.
Targeted therapy of irritable bowel syndrome with anti-inflammatory cytokines.
Sunil Kumar, Priyanka Singh, Awanish Kumar.
Clin J Gastroenterol, 2021 Dec 05;. PMID: 34862947