Journal Article
. 2013 Jan;3(1).
doi: 10.1158/2159-8290.CD-12-0462.

The genomic landscape of breast cancer as a therapeutic roadmap

Matthew J Ellis 1 Charles M Perou  
  • PMID: 23319768
  •     44 References
  •     81 citations


The application of high-throughput techniques to profile DNA, RNA, and protein in breast cancer samples from hundreds of patients has profoundly increased our knowledge of the disease. The etiologic events that drive breast cancer are finally coming into focus and should be used to set priorities for clinical trials. In this Prospective, we summarize some of the headline conclusions from 6 recent breast cancer "omics profiling" articles in Nature, with an emphasis on the implications for systemic therapy.

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Biomedicines, 2018 Nov 06; 6(4). PMID: 30388868    Free PMC article.
CBP/β-Catenin/FOXM1 Is a Novel Therapeutic Target in Triple Negative Breast Cancer.
Alexander Ring, Cu Nguyen, +5 authors, Julie E Lang.
Cancers (Basel), 2018 Dec 24; 10(12). PMID: 30572639    Free PMC article.
ESR1 alterations and metastasis in estrogen receptor positive breast cancer.
Jonathan T Lei, Xuxu Gou, Sinem Seker, Matthew J Ellis.
J Cancer Metastasis Treat, 2019 May 21; 5. PMID: 31106278    Free PMC article.
Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer.
Susana Ros, Alan J Wright, +21 authors, Kevin M Brindle.
Cancer Cell, 2020 Sep 26; 38(4). PMID: 32976773    Free PMC article.
Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity.
Aleix Prat, Barbara Adamo, +14 authors, Javier Cortés.
Sci Rep, 2014 Jan 05; 3. PMID: 24384914    Free PMC article.
Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers.
Sarah Naomi Olsen, Ania Wronski, +13 authors, Karen Cichowski.
Cancer Discov, 2016 Dec 16; 7(2). PMID: 27974415    Free PMC article.
Next-generation sequencing-based clinical sequencing: toward precision medicine in solid tumors.
Toshifumi Wakai, Pankaj Prasoon, +3 authors, Masayuki Nagahashi.
Int J Clin Oncol, 2018 Dec 06; 24(2). PMID: 30515675
Clinical target sequencing for precision medicine of breast cancer.
Junko Tsuchida, Jami Rothman, +3 authors, Toshifumi Wakai.
Int J Clin Oncol, 2019 Jan 04; 24(2). PMID: 30604156
Network-guided prediction of aromatase inhibitor response in breast cancer.
Matthew Ruffalo, Roby Thomas, +3 authors, Ziv Bar-Joseph.
PLoS Comput Biol, 2019 Feb 12; 15(2). PMID: 30742607    Free PMC article.
Ultradeep targeted sequencing of circulating tumor DNA in plasma of early and advanced breast cancer.
Yoon Ming Chin, Yoko Takahashi, +7 authors, Siew-Kee Low.
Cancer Sci, 2020 Oct 20; 112(1). PMID: 33075187    Free PMC article.
GREB1 regulates PI3K/Akt signaling to control hormone-sensitive breast cancer proliferation.
Corinne N Haines, Hope D Klingensmith, Makanko Komara, Craig J Burd.
Carcinogenesis, 2020 Sep 08; 41(12). PMID: 32894276    Free PMC article.
Targeted Neoadjuvant Therapies in HR+/HER2-Breast Cancers: Challenges for Improving pCR.
Nandini Dey, Jennifer Aske, Pradip De.
Cancers (Basel), 2021 Feb 04; 13(3). PMID: 33530335    Free PMC article.
Survival outcomes are associated with genomic instability in luminal breast cancers.
Lydia King, Andrew Flaus, Emma Holian, Aaron Golden.
PLoS One, 2021 Feb 04; 16(2). PMID: 33534788    Free PMC article.