Review
. 2013 Feb; 32(5):617-28.
doi: 10.1038/emboj.2013.19.

A new genome-driven integrated classification of breast cancer and its implications

Sarah-Jane Dawson 1 Oscar M Rueda  Samuel Aparicio  Carlos Caldas  
Affiliations
  • PMID: 23395906
  •     65 References
  •     122 citations

Abstract

Breast cancer is a group of heterogeneous diseases that show substantial variation in their molecular and clinical characteristics. This heterogeneity poses significant challenges not only in breast cancer management, but also in studying the biology of the disease. Recently, rapid progress has been made in understanding the genomic diversity of breast cancer. These advances led to the characterisation of a new genome-driven integrated classification of breast cancer, which substantially refines the existing classification systems currently used. The novel classification integrates molecular information on the genomic and transcriptomic landscapes of breast cancer to define 10 integrative clusters, each associated with distinct clinical outcomes and providing new insights into the underlying biology and potential molecular drivers. These findings have profound implications both for the individualisation of treatment approaches, bringing us a step closer to the realisation of personalised cancer management in breast cancer, but also provide a new framework for studying the underlying biology of each novel subtype.

High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer.
Suet F Chin, Andrew E Teschendorff, +13 authors, Carlos Caldas.
Genome Biol, 2007 Oct 11; 8(10). PMID: 17925008    Free PMC article.
Highly Cited.
Pathological prognostic factors in breast cancer.
C W Elston, I O Ellis, S E Pinder.
Crit Rev Oncol Hematol, 1999 Oct 26; 31(3). PMID: 10532196
Review.
Molecular portraits of human breast tumours.
C M Perou, T Sørlie, +15 authors, D Botstein.
Nature, 2000 Aug 30; 406(6797). PMID: 10963602
Highly Cited.
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
T Sørlie, C M Perou, +14 authors, A L Børresen-Dale.
Proc Natl Acad Sci U S A, 2001 Sep 13; 98(19). PMID: 11553815    Free PMC article.
Highly Cited.
Gene expression profiling predicts clinical outcome of breast cancer.
Laura J van 't Veer, Hongyue Dai, +13 authors, Stephen H Friend.
Nature, 2002 Feb 02; 415(6871). PMID: 11823860
Highly Cited.
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
Dmitry V Bulavin, Oleg N Demidov, +10 authors, Ettore Appella.
Nat Genet, 2002 May 22; 31(2). PMID: 12021785
Highly Cited.
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.
Diane C Fingar, Sofie Salama, +2 authors, John Blenis.
Genes Dev, 2002 Jun 25; 16(12). PMID: 12080086    Free PMC article.
Highly Cited.
A gene-expression signature as a predictor of survival in breast cancer.
Marc J van de Vijver, Yudong D He, +18 authors, René Bernards.
N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681
Highly Cited.
Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer.
Gottfried Konecny, Giovanni Pauletti, +12 authors, Dennis J Slamon.
J Natl Cancer Inst, 2003 Jan 17; 95(2). PMID: 12529347
Highly Cited.
Molecular classification of breast carcinomas using tissue microarrays.
Grace Callagy, Elena Cattaneo, +4 authors, Carlos Caldas.
Diagn Mol Pathol, 2003 Feb 27; 12(1). PMID: 12605033
The 17q23 amplicon and breast cancer.
Colleen S Sinclair, Matthew Rowley, Ali Naderi, Fergus J Couch.
Breast Cancer Res Treat, 2003 May 21; 78(3). PMID: 12755490
Review.
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Therese Sorlie, Robert Tibshirani, +13 authors, David Botstein.
Proc Natl Acad Sci U S A, 2003 Jun 28; 100(14). PMID: 12829800    Free PMC article.
Highly Cited.
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
Katherine M Hannan, Yves Brandenburger, +8 authors, Ross D Hannan.
Mol Cell Biol, 2003 Nov 13; 23(23). PMID: 14612424    Free PMC article.
Highly Cited.
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Luke Hughes-Davies, David Huntsman, +27 authors, Tony Kouzarides.
Cell, 2003 Dec 04; 115(5). PMID: 14651845
Highly Cited.
Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma.
Torsten O Nielsen, Forrest D Hsu, +13 authors, Charles M Perou.
Clin Cancer Res, 2004 Aug 26; 10(16). PMID: 15328174
Highly Cited.
Refinement of breast cancer classification by molecular characterization of histological special types.
B Weigelt, H M Horlings, +7 authors, J L Peterse.
J Pathol, 2008 Aug 23; 216(2). PMID: 18720457
Highly Cited.
A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer.
Andrew E Teschendorff, Carlos Caldas.
Breast Cancer Res, 2008 Aug 30; 10(4). PMID: 18755024    Free PMC article.
Supervised risk predictor of breast cancer based on intrinsic subtypes.
Joel S Parker, Michael Mullins, +17 authors, Philip S Bernard.
J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204204    Free PMC article.
Highly Cited.
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Bryan T Hennessy, Ana-Maria Gonzalez-Angulo, +24 authors, Gordon B Mills.
Cancer Res, 2009 May 14; 69(10). PMID: 19435916    Free PMC article.
Highly Cited.
Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.
Maggie C U Cheang, Stephen K Chia, +10 authors, Torsten O Nielsen.
J Natl Cancer Inst, 2009 May 14; 101(10). PMID: 19436038    Free PMC article.
Highly Cited.
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.
Elgene Lim, François Vaillant, +18 authors, Geoffrey J Lindeman.
Nat Med, 2009 Aug 04; 15(8). PMID: 19648928
Highly Cited.
Triple negative breast cancers: clinical and prognostic implications.
S J Dawson, E Provenzano, C Caldas.
Eur J Cancer, 2009 Sep 25; 45 Suppl 1. PMID: 19775602
Review.
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.
Sohrab P Shah, Ryan D Morin, +27 authors, Samuel Aparicio.
Nature, 2009 Oct 09; 461(7265). PMID: 19812674
Highly Cited.
A census of amplified and overexpressed human cancer genes.
Thomas Santarius, Janet Shipley, +2 authors, Colin S Cooper.
Nat Rev Cancer, 2009 Dec 24; 10(1). PMID: 20029424
Highly Cited. Review.
Complex landscapes of somatic rearrangement in human breast cancer genomes.
Philip J Stephens, David J McBride, +30 authors, Michael R Stratton.
Nature, 2009 Dec 25; 462(7276). PMID: 20033038    Free PMC article.
Highly Cited.
Genome remodelling in a basal-like breast cancer metastasis and xenograft.
Li Ding, Matthew J Ellis, +66 authors, Elaine R Mardis.
Nature, 2010 Apr 16; 464(7291). PMID: 20393555    Free PMC article.
Highly Cited.
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies.
Fiona M Blows, Kristy E Driver, +40 authors, David Huntsman.
PLoS Med, 2010 Jun 04; 7(5). PMID: 20520800    Free PMC article.
Highly Cited.
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients.
Hege G Russnes, Hans Kristian Moen Vollan, +20 authors, Anne-Lise Børresen-Dale.
Sci Transl Med, 2010 Jul 02; 2(38). PMID: 20592421    Free PMC article.
BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received.
S-J Dawson, N Makretsov, +17 authors, P Pharoah.
Br J Cancer, 2010 Jul 29; 103(5). PMID: 20664598    Free PMC article.
Highly Cited.
Breast cancer prognostic classification in the molecular era: the role of histological grade.
Emad A Rakha, Jorge S Reis-Filho, +15 authors, Ian O Ellis.
Breast Cancer Res, 2010 Sep 02; 12(4). PMID: 20804570    Free PMC article.
Highly Cited. Review.
A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer.
Torsten O Nielsen, Joel S Parker, +12 authors, Matthew J Ellis.
Clin Cancer Res, 2010 Sep 15; 16(21). PMID: 20837693    Free PMC article.
Highly Cited.
B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer.
Jing Tan, Puay Leng Lee, +4 authors, Qiang Yu.
Cancer Cell, 2010 Nov 16; 18(5). PMID: 21075311
ZNF703 gene amplification at 8p12 specifies luminal B breast cancer.
Fabrice Sircoulomb, Nathalie Nicolas, +19 authors, Christophe Ginestier.
EMBO Mol Med, 2011 Feb 18; 3(3). PMID: 21328542    Free PMC article.
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
Daniel G Holland, Angela Burleigh, +19 authors, Carlos Caldas.
EMBO Mol Med, 2011 Feb 22; 3(3). PMID: 21337521    Free PMC article.
Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization.
Euan M Slorach, Jonathan Chou, Zena Werb.
Genes Dev, 2011 Feb 15; 25(5). PMID: 21317240    Free PMC article.
Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas.
Melissa K McConechy, Michael S Anglesio, +15 authors, David G Huntsman.
J Pathol, 2011 Mar 08; 223(5). PMID: 21381030
High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.
Jewel Daniel, Jonathan Coulter, +2 authors, Edward Gabrielson.
Proc Natl Acad Sci U S A, 2011 Mar 16; 108(13). PMID: 21402910    Free PMC article.
Tumour evolution inferred by single-cell sequencing.
Nicholas Navin, Jude Kendall, +12 authors, Michael Wigler.
Nature, 2011 Mar 15; 472(7341). PMID: 21399628    Free PMC article.
Highly Cited.
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
Brian D Lehmann, Joshua A Bauer, +4 authors, Jennifer A Pietenpol.
J Clin Invest, 2011 Jun 03; 121(7). PMID: 21633166    Free PMC article.
Highly Cited.
Cancer sequencing unravels clonal evolution.
Carlos Caldas.
Nat Biotechnol, 2012 May 09; 30(5). PMID: 22565966
The life history of 21 breast cancers.
Serena Nik-Zainal, Peter Van Loo, +47 authors, Breast Cancer Working Group of the International Cancer Genome Consortium.
Cell, 2012 May 23; 149(5). PMID: 22608083    Free PMC article.
Highly Cited.
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
Sohrab P Shah, Andrew Roth, +56 authors, Samuel Aparicio.
Nature, 2012 Apr 13; 486(7403). PMID: 22495314    Free PMC article.
Highly Cited.
Whole-genome analysis informs breast cancer response to aromatase inhibition.
Matthew J Ellis, Li Ding, +56 authors, Elaine R Mardis.
Nature, 2012 Jun 23; 486(7403). PMID: 22722193    Free PMC article.
Highly Cited.
The landscape of cancer genes and mutational processes in breast cancer.
Philip J Stephens, Patrick S Tarpey, +60 authors, Michael R Stratton.
Nature, 2012 Jun 23; 486(7403). PMID: 22722201    Free PMC article.
Highly Cited.
Sequence analysis of mutations and translocations across breast cancer subtypes.
Shantanu Banerji, Kristian Cibulskis, +44 authors, Matthew Meyerson.
Nature, 2012 Jun 23; 486(7403). PMID: 22722202    Free PMC article.
Highly Cited.
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Christina Curtis, Sohrab P Shah, +29 authors, Samuel Aparicio.
Nature, 2012 Apr 24; 486(7403). PMID: 22522925    Free PMC article.
Highly Cited.
Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer.
H R Ali, S-J Dawson, +3 authors, C Caldas.
Br J Cancer, 2012 Apr 28; 106(11). PMID: 22538974    Free PMC article.
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer.
Aleix Prat, Joel S Parker, +5 authors, Charles M Perou.
Breast Cancer Res, 2010 Sep 04; 12(5). PMID: 20813035    Free PMC article.
Highly Cited.
TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer.
Alejandra Bruna, Wendy Greenwood, +9 authors, Carlos Caldas.
Nat Commun, 2012 Sep 13; 3. PMID: 22968701
Comprehensive molecular portraits of human breast tumours.
Cancer Genome Atlas Network.
Nature, 2012 Sep 25; 490(7418). PMID: 23000897    Free PMC article.
Highly Cited.
Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling.
Yinyin Yuan, Henrik Failmezger, +14 authors, Florian Markowetz.
Sci Transl Med, 2012 Oct 27; 4(157). PMID: 23100629
Highly Cited.
Two-color FISH characterization of i(1q) and der(1;16) in human breast cancer cells.
N Kokalj-Vokac, A Alemeida, +2 authors, B Dutrillaux.
Genes Chromosomes Cancer, 1993 May 01; 7(1). PMID: 7688559
Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer.
R Roylance, P Gorman, +4 authors, D Sheer.
Cancer Res, 1999 Apr 10; 59(7). PMID: 10197608
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Protein expression profiling identifies subclasses of breast cancer and predicts prognosis.
Jocelyne Jacquemier, Christophe Ginestier, +11 authors, François Bertucci.
Cancer Res, 2005 Feb 12; 65(3). PMID: 15705873
High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses.
Dalia M Abd El-Rehim, Graham Ball, +6 authors, Ian O Ellis.
Int J Cancer, 2005 Apr 09; 116(3). PMID: 15818618
Highly Cited.
The molecular portraits of breast tumors are conserved across microarray platforms.
Zhiyuan Hu, Cheng Fan, +28 authors, Charles M Perou.
BMC Genomics, 2006 Apr 29; 7. PMID: 16643655    Free PMC article.
Highly Cited.
Novel patterns of genome rearrangement and their association with survival in breast cancer.
James Hicks, Alexander Krasnitz, +20 authors, Anders Zetterberg.
Genome Res, 2006 Dec 05; 16(12). PMID: 17142309    Free PMC article.
Highly Cited.
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.
Koei Chin, Sandy DeVries, +21 authors, Joe W Gray.
Cancer Cell, 2006 Dec 13; 10(6). PMID: 17157792
Highly Cited.
High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer.
J Pärssinen, T Kuukasjärvi, R Karhu, A Kallioniemi.
Br J Cancer, 2007 Mar 14; 96(8). PMID: 17353917    Free PMC article.
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
Lyndsay Harris, Herbert Fritsche, +7 authors, American Society of Clinical Oncology.
J Clin Oncol, 2007 Oct 24; 25(33). PMID: 17954709
Highly Cited. Review.
An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer.
Andrew E Teschendorff, Ahmad Miremadi, +2 authors, Carlos Caldas.
Genome Biol, 2007 Aug 09; 8(8). PMID: 17683518    Free PMC article.
Highly Cited.
Development of the 21-gene assay and its application in clinical practice and clinical trials.
Joseph A Sparano, Soonmyung Paik.
J Clin Oncol, 2008 Feb 09; 26(5). PMID: 18258979
Highly Cited. Review.
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E.
Diane C Fingar, Celeste J Richardson, +3 authors, John Blenis.
Mol Cell Biol, 2003 Dec 16; 24(1). PMID: 14673156    Free PMC article.
Highly Cited.
Clinical application of the 70-gene profile: the MINDACT trial.
Fatima Cardoso, Laura Van't Veer, +3 authors, Martine J Piccart-Gebhart.
J Clin Oncol, 2008 Feb 09; 26(5). PMID: 18258980
Highly Cited.
Video Q&A: molecular profiling of breast cancer.
Carlos Caldas.
BMC Med, 2013 Jun 27; 11. PMID: 23800190    Free PMC article.
[Personalized urooncology based on molecular uropathology: what is the future?].
E Dahl, F Haller.
Urologe A, 2013 Jul 09; 52(7). PMID: 23831986
Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm.
Ferdinando Mannello.
BMC Med, 2013 Jul 25; 11. PMID: 23879988    Free PMC article.
Review.
Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling.
Xi Zhang, Xin Mu, +4 authors, Kunwei Shen.
PLoS One, 2013 Aug 31; 8(8). PMID: 23991038    Free PMC article.
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.
Suzanne A Eccles, Eric O Aboagye, +84 authors, Alastair M Thompson.
Breast Cancer Res, 2013 Nov 30; 15(5). PMID: 24286369    Free PMC article.
Highly Cited. Review.
Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing.
Milan Radovich, Susan E Clare, +24 authors, Bryan P Schneider.
Breast Cancer Res Treat, 2013 Dec 03; 143(1). PMID: 24292813    Free PMC article.
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.
Maria T Grinde, Nirma Skrbo, +11 authors, Ingrid S Gribbestad.
Breast Cancer Res, 2014 Jan 23; 16(1). PMID: 24447408    Free PMC article.
Taxonomy of breast cancer based on normal cell phenotype predicts outcome.
Sandro Santagata, Ankita Thakkar, +13 authors, Tan A Ince.
J Clin Invest, 2014 Jan 28; 124(2). PMID: 24463450    Free PMC article.
Highly Cited.
High-throughput gene expression and mutation profiling: current methods and future perspectives.
Thomas Karn.
Breast Care (Basel), 2014 Feb 20; 8(6). PMID: 24550747    Free PMC article.
Review.
Baseline staging tests based on molecular subtype is necessary for newly diagnosed breast cancer.
Xuesong Chen, Lichun Sun, +8 authors, Xiaoqun Dong.
J Exp Clin Cancer Res, 2014 Mar 19; 33. PMID: 24628817    Free PMC article.
A microRNA signature associated with early recurrence in breast cancer.
Luis G Pérez-Rivas, José M Jerez, +9 authors, José Lozano.
PLoS One, 2014 Mar 19; 9(3). PMID: 24632820    Free PMC article.
Polarity gene alterations in pure invasive micropapillary carcinomas of the breast.
Nadège Gruel, Vanessa Benhamo, +10 authors, Anne Vincent-Salomon.
Breast Cancer Res, 2014 Jun 03; 16(3). PMID: 24887297    Free PMC article.
How many etiological subtypes of breast cancer: two, three, four, or more?
William F Anderson, Philip S Rosenberg, +2 authors, Mark E Sherman.
J Natl Cancer Inst, 2014 Aug 15; 106(8). PMID: 25118203    Free PMC article.
Highly Cited. Review.
Keratin 19 expression correlates with poor prognosis in breast cancer.
Nuzhat N Kabir, Lars Rönnstrand, Julhash U Kazi.
Mol Biol Rep, 2014 Aug 27; 41(12). PMID: 25156534
Genome-driven integrated classification of breast cancer validated in over 7,500 samples.
H Raza Ali, Oscar M Rueda, +4 authors, Carlos Caldas.
Genome Biol, 2014 Aug 29; 15(8). PMID: 25164602    Free PMC article.
Highly Cited.
Normal cell phenotypes of breast epithelial cells provide the foundation of a breast cancer taxonomy.
Sandro Santagata, Tan A Ince.
Expert Rev Anticancer Ther, 2014 Sep 30; 14(12). PMID: 25263303    Free PMC article.
Wip1 phosphatase in breast cancer.
A Emelyanov, D V Bulavin.
Oncogene, 2014 Nov 11; 34(34). PMID: 25381821
Review.
Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected]. .
Britta Weigelt, Charlotte K Y Ng, +8 authors, Jorge S Reis-Filho.
Mod Pathol, 2014 Nov 22; 28(3). PMID: 25412848    Free PMC article.
Genomic profiling of breast cancers.
Christina Curtis.
Curr Opin Obstet Gynecol, 2014 Dec 17; 27(1). PMID: 25502431    Free PMC article.
Review.
Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer.
Andrew T Baker, Andrei Zlobin, Clodia Osipo.
Front Oncol, 2015 Jan 08; 4. PMID: 25566499    Free PMC article.
Review.
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.
Angela Burleigh, Steven McKinney, +11 authors, Samuel Aparicio.
Breast Cancer Res, 2015 Jan 13; 17. PMID: 25572802    Free PMC article.
Normal cell-type epigenetics and breast cancer classification: a case study of cell mixture-adjusted analysis of DNA methylation data from tumors.
Eugene Andrés Houseman, Tan A Ince.
Cancer Inform, 2015 Jan 13; 13(Suppl 4). PMID: 25574126    Free PMC article.
Proteogenomics: emergence and promise.
Sam Faulkner, Matthew D Dun, Hubert Hondermarck.
Cell Mol Life Sci, 2015 Jan 23; 72(5). PMID: 25609363
The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2.
Oluwafunmilayo F Lamidi, Monica Sani, +2 authors, Ian N Fleming.
J Cancer Res Clin Oncol, 2015 Jan 31; 141(9). PMID: 25633717
Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures.
Angelika Modelska, Alessandro Quattrone, Angela Re.
Brief Bioinform, 2015 Apr 03; 16(6). PMID: 25832647    Free PMC article.
Review.
OECI-EACR precision medicine for cancer: Conference report 1-4 March 2015, Luxembourg.
Anna Golebiewska, Sabrina Fritah, Maria Romina Girotti.
Ecancermedicalscience, 2015 May 02; 9. PMID: 25932043    Free PMC article.
Proteotranscriptomic Profiling of 231-BR Breast Cancer Cells: Identification of Potential Biomarkers and Therapeutic Targets for Brain Metastasis.
Matthew D Dun, Robert J Chalkley, +8 authors, Hubert Hondermarck.
Mol Cell Proteomics, 2015 Jun 05; 14(9). PMID: 26041846    Free PMC article.
Simultaneous visualization of tumour oxygenation, neovascularization and contrast agent perfusion by real-time three-dimensional optoacoustic tomography.
Vladimir Ermolayev, Xose Luis Dean-Ben, +2 authors, Daniel Razansky.
Eur Radiol, 2015 Sep 04; 26(6). PMID: 26334513
Breast cancer dissemination promoted by a neuregulin-collagenase 3 signalling node.
S Seoane, J C Montero, A Ocaña, A Pandiella.
Oncogene, 2015 Sep 15; 35(21). PMID: 26364598
Neoadjuvant trials in early breast cancer: pathological response at surgery and correlation to longer term outcomes - what does it all mean?
Helena Earl, Elena Provenzano, +4 authors, Louise Hiller.
BMC Med, 2015 Sep 24; 13. PMID: 26391216    Free PMC article.
Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity.
Aristeidis G Telonis, Phillipe Loher, +2 authors, Isidore Rigoutsos.
Nucleic Acids Res, 2015 Sep 25; 43(19). PMID: 26400174    Free PMC article.
Highly Cited.
Next-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us?
Veronique G LeBlanc, Marco A Marra.
Cancers (Basel), 2015 Sep 26; 7(3). PMID: 26404381    Free PMC article.
Review.
Big Data: the challenge for small research groups in the era of cancer genomics.
Aisyah Mohd Noor, Lars Holmberg, Cheryl Gillett, Anita Grigoriadis.
Br J Cancer, 2015 Oct 23; 113(10). PMID: 26492224    Free PMC article.
Review.
Developmental Insights into Breast Cancer Intratumoral Heterogeneity.
Mei Zhang, Jeffrey M Rosen.
Trends Cancer, 2016 Jan 12; 1(4). PMID: 26753176    Free PMC article.
Cell-free circulating tumour DNA as a liquid biopsy in breast cancer.
Leticia De Mattos-Arruda, Carlos Caldas.
Mol Oncol, 2016 Jan 19; 10(3). PMID: 26776681    Free PMC article.
Review.
A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.
Ahmet Acar, Bruno M Simões, Robert B Clarke, Keith Brennan.
Stem Cells Int, 2016 Feb 18; 2016. PMID: 26880941    Free PMC article.
Review.
RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer.
Nyam-Osor Chimge, Gillian H Little, +15 authors, Baruch Frenkel.
Nat Commun, 2016 Feb 27; 7. PMID: 26916619    Free PMC article.
Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion.
Chanèle Cyr-Depauw, Jason J Northey, +7 authors, Peter M Siegel.
Mol Cell Biol, 2016 Mar 16; 36(10). PMID: 26976638    Free PMC article.
Omics Profiling in Precision Oncology.
Kun-Hsing Yu, Michael Snyder.
Mol Cell Proteomics, 2016 Apr 22; 15(8). PMID: 27099341    Free PMC article.
Review.
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.
Bernard Pereira, Suet-Feung Chin, +31 authors, Carlos Caldas.
Nat Commun, 2016 May 11; 7. PMID: 27161491    Free PMC article.
Highly Cited.
Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer.
Sedef Iskit, Cor Lieftink, +4 authors, Daniel S Peeper.
Oncotarget, 2016 Jul 05; 7(28). PMID: 27374095    Free PMC article.
Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer.
Libero Santarpia, Giulia Bottai, +3 authors, Lajos Pusztai.
Oncologist, 2016 Jul 08; 21(9). PMID: 27384237    Free PMC article.
Review.
Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups.
Dvir Netanely, Ayelet Avraham, +2 authors, Ron Shamir.
Breast Cancer Res, 2016 Jul 09; 18(1). PMID: 27386846    Free PMC article.
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer.
Aldema Sas-Chen, Miriam R Aure, +17 authors, Yosef Yarden.
EMBO Mol Med, 2016 Aug 04; 8(9). PMID: 27485121    Free PMC article.
Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities.
Caren E Smith, Stephanie M Fullerton, +7 authors, José M Ordovás.
Health Aff (Millwood), 2016 Aug 10; 35(8). PMID: 27503959    Free PMC article.
Review.
A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.
Alejandra Bruna, Oscar M Rueda, +27 authors, Carlos Caldas.
Cell, 2016 Sep 20; 167(1). PMID: 27641504    Free PMC article.
Highly Cited.
Breast cancer classification and prognostication through diverse systems along with recent emerging findings in this respect; the dawn of new perspectives in the clinical applications.
Vida Pourteimoor, Samira Mohammadi-Yeganeh, Mahdi Paryan.
Tumour Biol, 2016 Sep 22; 37(11). PMID: 27651157
Review.
Meroxest improves the prognosis of immunocompetent C57BL/6 mice with allografts of E0771 mouse breast tumor cells.
Esther Carrasco, Jose Manuel Garrido, +6 authors, Fernando Rodríguez-Serrano.
Arch Med Sci, 2016 Oct 04; 12(5). PMID: 27695480    Free PMC article.
Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor α in breast cancer cells.
Lydia Edjekouane, Samira Benhadjeba, +4 authors, André Tremblay.
Oncotarget, 2016 Oct 21; 7(47). PMID: 27764788    Free PMC article.
Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: national cohort study in England.
Henrik Møller, Katherine Henson, +10 authors, Arnie Purushotham.
Br J Cancer, 2016 Oct 26; 115(11). PMID: 27780193    Free PMC article.
Double-edged role of G protein-coupled estrogen receptor 1 in breast cancer prognosis: an analysis of 167 breast cancer samples and online data sets.
Fan Yang, Zhi-Min Shao.
Onco Targets Ther, 2016 Nov 09; 9. PMID: 27822058    Free PMC article.
Trastuzumab-associated cardiac events in the Persephone trial.
Helena M Earl, Anne-Laure Vallier, +12 authors, Louise Hiller.
Br J Cancer, 2016 Nov 23; 115(12). PMID: 27875516    Free PMC article.
Interrogating open issues in cancer precision medicine with patient-derived xenografts.
Annette T Byrne, Denis G Alférez, +39 authors, Livio Trusolino.
Nat Rev Cancer, 2017 Jan 21; 17(4). PMID: 28104906
Highly Cited. Review.
Glycoproteins in Claudin-Low Breast Cancer Cell Lines Have a Unique Expression Profile.
Ten-Yang Yen, Spencer Bowen, +3 authors, Leslie C Timpe.
J Proteome Res, 2017 Mar 14; 16(4). PMID: 28287265    Free PMC article.
Value of circulating cell-free DNA analysis as a diagnostic tool for breast cancer: a meta-analysis.
Ziqiang Lin, James Neiswender, +3 authors, Xiuying Hu.
Oncotarget, 2017 May 04; 8(16). PMID: 28460452    Free PMC article.
Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas.
Gregor Krings, Nancy M Joseph, +12 authors, Yunn-Yi Chen.
Mod Pathol, 2017 May 27; 30(8). PMID: 28548128
let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery.
A Spolverini, G Fuchs, D R Bublik, M Oren.
Oncogene, 2017 Jun 13; 36(42). PMID: 28604753    Free PMC article.
Novel therapeutic strategies in the treatment of triple-negative breast cancer.
Karima Oualla, Heba M El-Zawahry, +7 authors, Tamer M Fouad.
Ther Adv Med Oncol, 2017 Jul 19; 9(7). PMID: 28717401    Free PMC article.
Review.
Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants.
Fresia Pareja, Felipe C Geyer, +3 authors, Jorge S Reis-Filho.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721389    Free PMC article.
Highly Cited. Review.
Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation.
Keith A Dookeran, Wei Zhang, Leslie Stayner, Maria Argos.
BMC Res Notes, 2017 Sep 14; 10(1). PMID: 28899398    Free PMC article.
New insights into the metastatic behavior after breast cancer surgery, according to well-established clinicopathological variables and molecular subtypes.
Oreste Claudio Buonomo, Emanuele Caredda, +6 authors, Paolo Orsaria.
PLoS One, 2017 Sep 19; 12(9). PMID: 28922402    Free PMC article.
PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients.
Nicholas P Tobin, Arian Lundberg, +13 authors, TEX Trialists Group.
Clin Cancer Res, 2017 Oct 04; 23(23). PMID: 28972041    Free PMC article.
Mammalian sterile 20-like kinase 1 expression and its prognostic significance in patients with breast cancer.
Xiao-Yan Lin, Feng-Feng Cai, +6 authors, Ewelina Biskup.
Oncol Lett, 2017 Nov 04; 14(5). PMID: 29098035    Free PMC article.
Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer.
Nora Fernandez-Jimenez, Athena Sklias, +7 authors, Zdenko Herceg.
Epigenetics, 2017 Nov 04; 12(11). PMID: 29099283    Free PMC article.
Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer.
Daniel G Stover, Heather A Parsons, +20 authors, Viktor A Adalsteinsson.
J Clin Oncol, 2018 Jan 04; 36(6). PMID: 29298117    Free PMC article.
Highly Cited.
Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.
K L Thu, J Silvester, +9 authors, D W Cescon.
Proc Natl Acad Sci U S A, 2018 Jan 31; 115(7). PMID: 29378962    Free PMC article.
HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.
Anneleen Daemen, Gerard Manning.
Breast Cancer Res, 2018 Feb 01; 20(1). PMID: 29382369    Free PMC article.
Prognostic & predictive factors for planning adjuvant chemotherapy of early-stage breast cancer.
Onur Esbah, Berna Oksuzoglu.
Indian J Med Res, 2018 Mar 08; 146(5). PMID: 29512598    Free PMC article.
Review.
Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort.
A Mukherjee, R Russell, +9 authors, E Provenzano.
NPJ Breast Cancer, 2018 Mar 14; 4. PMID: 29532008    Free PMC article.
The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes.
Rokaya El Ansari, Madeleine L Craze, +4 authors, Andrew R Green.
Br J Cancer, 2018 Mar 17; 118(8). PMID: 29545595    Free PMC article.
The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours.
Rokaya El Ansari, Madeleine L Craze, +5 authors, Andrew R Green.
Breast Cancer Res, 2018 Mar 24; 20(1). PMID: 29566741    Free PMC article.
Highly Cited.
Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes.
Chitra Joseph, Olivia Macnamara, +10 authors, Abhik Mukherjee.
Br J Cancer, 2018 Mar 29; 118(8). PMID: 29588513    Free PMC article.
Spatial intratumoural heterogeneity in the expression of GIT1 is associated with poor prognostic outcome in oestrogen receptor positive breast cancer patients with synchronous lymph node metastases.
Ibai Goicoechea, Ricardo Rezola, +15 authors, Charles H Lawrie.
F1000Res, 2018 Jun 07; 6. PMID: 29862012    Free PMC article.
Probabilistic graphical models relate immune status with response to neoadjuvant chemotherapy in breast cancer.
Andrea Zapater-Moros, Angelo Gámez-Pozo, +9 authors, Juan Ángel Fresno Vara.
Oncotarget, 2018 Jul 03; 9(45). PMID: 29963222    Free PMC article.
Clinicopathologic Factors Related to the Histological Tumor Grade of Breast Cancer in Western China: An Epidemiological Multicenter Study of 8619 Female Patients.
Ke Zheng, Jin-Xiang Tan, +21 authors, Guo-Sheng Ren.
Transl Oncol, 2018 Jul 10; 11(4). PMID: 29982100    Free PMC article.
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Hidenori Kage, Per Flodby, Beiyun Zhou, Zea Borok.
Cell Mol Life Sci, 2019 Jul 25; 76(23). PMID: 31332482    Free PMC article.
Review.
Berberine attenuates XRCC1-mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.
Xingjie Gao, Jing Wang, +8 authors, Weifeng Mao.
J Cell Mol Med, 2019 Jul 25; 23(10). PMID: 31338966    Free PMC article.
Deciphering HER2 Breast Cancer Disease: Biological and Clinical Implications.
Ana Godoy-Ortiz, Alfonso Sanchez-Muñoz, +4 authors, Emilio Alba.
Front Oncol, 2019 Nov 19; 9. PMID: 31737566    Free PMC article.
Review.
Tumor diversity and the trade-off between universal cancer tasks.
Jean Hausser, Pablo Szekely, +4 authors, Uri Alon.
Nat Commun, 2019 Nov 30; 10(1). PMID: 31780652    Free PMC article.
Immune gene expression profiling reveals heterogeneity in luminal breast tumors.
Bin Zhu, Lap Ah Tse, +31 authors, Xiaohong R Yang.
Breast Cancer Res, 2019 Dec 21; 21(1). PMID: 31856876    Free PMC article.
Therapeutic and Mechanistic Perspectives of Protein Complexes in Breast Cancer.
Mark P Waterhouse, Rosie Ugur, Walid T Khaled.
Front Cell Dev Biol, 2020 Jan 11; 7. PMID: 31921847    Free PMC article.
Diagnostic value of seven biomarkers for breast cancer: an overview with evidence mapping and indirect comparisons of diagnostic test accuracy.
Ya Gao, Ming Liu, +7 authors, Cancer Biomarker Assessment Working Group.
Clin Exp Med, 2020 Jan 03; 20(1). PMID: 31894424
Systematic Review.
The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer.
Abrar I Aljohani, Michael S Toss, +8 authors, Emad A Rakha.
Breast Cancer Res Treat, 2019 Oct 11; 179(1). PMID: 31599393    Free PMC article.
Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer.
Nan Shao, Yawei Shi, +5 authors, Ying Lin.
Int J Biol Sci, 2019 Jun 12; 15(5). PMID: 31182917    Free PMC article.
Review.
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state.
Gloria V Echeverria, Zhongqi Ge, +27 authors, Helen Piwnica-Worms.
Sci Transl Med, 2019 Apr 19; 11(488). PMID: 30996079    Free PMC article.
Highly Cited.
Breast cancer treatment and its effects on aging.
Leslie Chang, Lauren S Weiner, +4 authors, Deborah M Kado.
J Geriatr Oncol, 2018 Aug 07; 10(2). PMID: 30078714    Free PMC article.
Review.
HDAC5 Inhibitors as a Potential Treatment in Breast Cancer Affecting Very Young Women.
Sara S Oltra, Juan Miguel Cejalvo, +13 authors, María Teresa Martinez.
Cancers (Basel), 2020 Feb 14; 12(2). PMID: 32050699    Free PMC article.
Copy number alternations of the 17q23-rs6504950 locus are associated with advanced breast cancers in Taiwanese women.
Chien-Yu Lin, Shu-Fen Yang, Yu-Ling Ho, Cheng-Mao Ho.
Ci Ji Yi Xue Za Zhi, 2020 Apr 10; 32(2). PMID: 32269954    Free PMC article.
The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes.
Elisabet Cuyàs, Juan Gumuzio, +7 authors, Javier A Menendez.
Aging (Albany NY), 2020 Mar 20; 12(6). PMID: 32191225    Free PMC article.
Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.
Ugo Testa, Germana Castelli, Elvira Pelosi.
Med Sci (Basel), 2020 Mar 27; 8(1). PMID: 32210163    Free PMC article.
Review.
Expressions of miR-21 and miR-210 in Breast Cancer and Their Predictive Values for Prognosis.
Xiaofei Wu.
Iran J Public Health, 2020 Apr 21; 49(1). PMID: 32309220    Free PMC article.
The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer.
Rokaya El Ansari, Lutfi Alfarsi, +4 authors, Andrew R Green.
Breast Cancer Res Treat, 2020 Mar 23; 181(1). PMID: 32200487    Free PMC article.
Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer.
Abrar I Aljohani, Chitra Joseph, +4 authors, Emad A Rakha.
Breast Cancer Res Treat, 2020 May 01; 181(3). PMID: 32350677    Free PMC article.
Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing.
Timour Baslan, Jude Kendall, +22 authors, James Hicks.
Elife, 2020 May 14; 9. PMID: 32401198    Free PMC article.
PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer.
Lutfi H Alfarsi, Rokaya El Ansari, +4 authors, Andrew R Green.
BMC Cancer, 2020 May 16; 20(1). PMID: 32410585    Free PMC article.
Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.
Bethany Mason, Susanne Flach, +6 authors, Heike Laman.
Cell Mol Life Sci, 2019 Sep 29; 77(13). PMID: 31560077    Free PMC article.
Starvation stress attenuates the miRNA-target interaction in suppressing breast cancer cell proliferation.
Jinhui Lü, Chuyi Zhang, +8 authors, Zuoren Yu.
BMC Cancer, 2020 Jul 08; 20(1). PMID: 32631271    Free PMC article.
Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution.
Roxane M Pommier, Amélien Sanlaville, +10 authors, Alain Puisieux.
Nat Commun, 2020 Jul 11; 11(1). PMID: 32647202    Free PMC article.
Polygenic Risk Scores for Subtyping of Schizophrenia.
Jingchun Chen, Travis Mize, +7 authors, Xiangning Chen.
Schizophr Res Treatment, 2020 Aug 11; 2020. PMID: 32774919    Free PMC article.
Establishment of primary human breast cancer cell lines using "pulsed hypoxia" method and development of metastatic tumor model in immunodeficient mice.
Anna A Nushtaeva, Anastasia A Karpushina, +8 authors, Olga A Koval.
Cancer Cell Int, 2019 Mar 13; 19. PMID: 30858763    Free PMC article.
Clinicopathological and epidemiological significance of breast cancer subtype reclassification based on p53 immunohistochemical expression.
Mustapha Abubakar, Changyuan Guo, +9 authors, Xiaohong R Yang.
NPJ Breast Cancer, 2019 Aug 03; 5. PMID: 31372496    Free PMC article.
Circulating tumour DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: A cohort study.
Andjelija Zivanovic Bujak, Chen-Fang Weng, +12 authors, Sarah-Jane Dawson.
PLoS Med, 2020 Oct 02; 17(10). PMID: 33001984    Free PMC article.
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.
Zhong Y Yeow, Bramwell G Lambrus, +17 authors, Andrew J Holland.
Nature, 2020 Sep 11; 585(7825). PMID: 32908313    Free PMC article.
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer.
Kyung-Min Lee, Angel L Guerrero-Zotano, +13 authors, Carlos L Arteaga.
Nat Commun, 2020 Nov 01; 11(1). PMID: 33127913    Free PMC article.
The nucleolar-related protein Dyskerin pseudouridine synthase 1 (DKC1) predicts poor prognosis in breast cancer.
Khloud A Elsharawy, Omar J Mohammed, +6 authors, Emad A Rakha.
Br J Cancer, 2020 Sep 02; 123(10). PMID: 32868896    Free PMC article.
Multi-Omics Analysis Detects Novel Prognostic Subgroups of Breast Cancer.
Quang-Huy Nguyen, Hung Nguyen, Tin Nguyen, Duc-Hau Le.
Front Genet, 2020 Nov 17; 11. PMID: 33193681    Free PMC article.
Comprehensive Genomic Profile of Heterogeneous Long Follow-Up Triple-Negative Breast Cancer and Its Clinical Characteristics Shows DNA Repair Deficiency Has Better Prognostic.
Ernesto Rojas-Jiménez, Javier César Mejía-Gómez, +18 authors, Felipe Vaca-Paniagua.
Genes (Basel), 2020 Nov 25; 11(11). PMID: 33227964    Free PMC article.
Life and cancer without telomerase: ALT and other strategies for making sure ends (don't) meet.
Manasi S Apte, Julia Promisel Cooper.
Crit Rev Biochem Mol Biol, 2016 Nov 29; 52(1). PMID: 27892716    Free PMC article.
Review.
The Detection and Morphological Analysis of Circulating Tumor and Host Cells in Breast Cancer Xenograft Models.
Loredana Cleris, Maria Grazia Daidone, Emanuela Fina, Vera Cappelletti.
Cells, 2019 Jul 10; 8(7). PMID: 31284534    Free PMC article.
Utility of Circulating Tumor DNA in Different Clinical Scenarios of Breast Cancer.
Alexandra Mesquita, José Luís Costa, Fernando Schmitt.
Cancers (Basel), 2020 Dec 20; 12(12). PMID: 33339259    Free PMC article.
Review.
Optimum duration of adjuvant trastuzumab in treatment of human epidermal growth factor receptor-2 positive early breast cancer: protocol for a network meta-analysis of randomised controlled trials.
Qiancheng Hu, Xin Wang, +3 authors, Dan Cao.
BMJ Open, 2021 Jan 15; 10(11). PMID: 33444169    Free PMC article.
Survival outcomes are associated with genomic instability in luminal breast cancers.
Lydia King, Andrew Flaus, Emma Holian, Aaron Golden.
PLoS One, 2021 Feb 04; 16(2). PMID: 33534788    Free PMC article.
Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer.
Emily L Duderstadt, Sarah A McQuaide, Mary A Sanders, David J Samuelson.
Physiol Genomics, 2020 Dec 22; 53(2). PMID: 33346690    Free PMC article.
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.
Dimitra Georgopoulou, Maurizio Callari, +21 authors, Carlos Caldas.
Nat Commun, 2021 Apr 02; 12(1). PMID: 33790302    Free PMC article.
Assessing the contribution of tumor mutational phenotypes to cancer progression risk.
Yifeng Tao, Ashok Rajaraman, +7 authors, Russell Schwartz.
PLoS Comput Biol, 2021 Mar 13; 17(3). PMID: 33711014    Free PMC article.
The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells.
Federica Zilli, Pedro Marques Ramos, +13 authors, Mohamed Bentires-Alj.
EMBO Mol Med, 2021 Mar 23; 13(4). PMID: 33751828    Free PMC article.
Characterisation of PALB2 tumours through whole-exome and whole-transcriptomic analyses.
Pei Sze Ng, Jia Wern Pan, +9 authors, Soo Hwang Teo.
NPJ Breast Cancer, 2021 Apr 25; 7(1). PMID: 33893315    Free PMC article.
S100A4 Is Involved in Stimulatory Effects Elicited by the FGF2/FGFR1 Signaling Pathway in Triple-Negative Breast Cancer (TNBC) Cells.
Maria Francesca Santolla, Marianna Talia, Marcello Maggiolini.
Int J Mol Sci, 2021 May 06; 22(9). PMID: 33946884    Free PMC article.
Circulating immune cell populations related to primary breast cancer, surgical removal, and radiotherapy revealed by flow cytometry analysis.
Sarah Cattin, Benoît Fellay, +8 authors, Curzio Rüegg.
Breast Cancer Res, 2021 Jun 07; 23(1). PMID: 34090509    Free PMC article.
SLC7A5 serves as a prognostic factor of breast cancer and promotes cell proliferation through activating AKT/mTORC1 signaling pathway.
Yuan Li, Wei Wang, +3 authors, Peilin Huang.
Ann Transl Med, 2021 Jun 25; 9(10). PMID: 34164526    Free PMC article.
Stem cell therapy: A paradigm shift in breast cancer treatment.
Sabiha Khan, Moushumi Suryavanshi, +5 authors, Simran Tandon.
World J Stem Cells, 2021 Aug 10; 13(7). PMID: 34367480    Free PMC article.
Review.
The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer.
Brendah K Masisi, Rokaya El Ansari, +7 authors, Andrew R Green.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439127    Free PMC article.