Journal Article
. 2013 Feb; 14(4):404-12.
doi: 10.1038/ni.2536.

Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation

J Adam Best 1 David A Blair  Jamie Knell  Edward Yang  Viveka Mayya  Andrew Doedens  Michael L Dustin  Ananda W Goldrath  Immunological Genome Project Consortium  
  • PMID: 23396170
  •     35 References
  •     156 citations


After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived memory CD8+ cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8+ effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8+ T cell immunity.

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PLoS Negl Trop Dis, 2017 May 31; 11(5). PMID: 28558022    Free PMC article.
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Qiang Shan, Zhouhao Zeng, +13 authors, Hai-Hui Xue.
Nat Immunol, 2017 Jun 13; 18(8). PMID: 28604718    Free PMC article.
Highly Cited.
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.
Anusha-Preethi Ganesan, James Clarke, +14 authors, Christian H Ottensmeier.
Nat Immunol, 2017 Jun 20; 18(8). PMID: 28628092    Free PMC article.
Highly Cited.
CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation.
Holger Lingel, Josef Wissing, +7 authors, Monika C Brunner-Weinzierl.
Cell Death Differ, 2017 Jun 24; 24(10). PMID: 28644433    Free PMC article.
Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
Alexandria C Wells, Keith A Daniels, +7 authors, Leonid A Pobezinsky.
Elife, 2017 Jul 25; 6. PMID: 28737488    Free PMC article.
Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
Hyun Mu Shin, Varun N Kapoor, +9 authors, Leslie J Berg.
PLoS Pathog, 2017 Aug 23; 13(8). PMID: 28827827    Free PMC article.
The spectrum of T cell metabolism in health and disease.
Glenn R Bantug, Lorenzo Galluzzi, Guido Kroemer, Christoph Hess.
Nat Rev Immunol, 2017 Sep 26; 18(1). PMID: 28944771
Highly Cited. Review.
FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity.
Arnaud Delpoux, Chen-Yen Lai, Stephen M Hedrick, Andrew L Doedens.
Proc Natl Acad Sci U S A, 2017 Oct 05; 114(42). PMID: 28973925    Free PMC article.
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.
J Justin Milner, Clara Toma, +10 authors, Ananda W Goldrath.
Nature, 2017 Dec 07; 552(7684). PMID: 29211713    Free PMC article.
Highly Cited.
Redirection to the bone marrow improves T cell persistence and antitumor functions.
Anjum B Khan, Ben Carpenter, +19 authors, Ronjon Chakraverty.
J Clin Invest, 2018 Feb 28; 128(5). PMID: 29485974    Free PMC article.
Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease.
Pedro Santos E Sousa, Séverine Ciré, +15 authors, Ronjon Chakraverty.
JCI Insight, 2018 Mar 09; 3(5). PMID: 29515032    Free PMC article.
Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.
Raul Vizcardo, Nicholas D Klemen, +20 authors, Nicholas P Restifo.
Cell Rep, 2018 Mar 22; 22(12). PMID: 29562175    Free PMC article.
Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division.
Armelle Bohineust, Zacarias Garcia, +2 authors, Philippe Bousso.
J Exp Med, 2018 Mar 29; 215(5). PMID: 29588347    Free PMC article.
Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy.
Frederick S Varn, Laura J Tafe, Christopher I Amos, Chao Cheng.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872556    Free PMC article.
Prolonged Evolution of Virus-Specific Memory T Cell Immunity after Severe Avian Influenza A (H7N9) Virus Infection.
Min Zhao, Junbo Chen, +16 authors, Hongjie Yu.
J Virol, 2018 Jun 22; 92(17). PMID: 29925664    Free PMC article.
Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells.
Debra K Newman, Guoping Fu, +7 authors, Matthew J Riese.
J Leukoc Biol, 2018 Aug 01; 104(5). PMID: 30063264    Free PMC article.
B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation.
Mark D Singh, Minjian Ni, +2 authors, Daniel J Campbell.
J Exp Med, 2018 Aug 11; 215(9). PMID: 30093532    Free PMC article.
Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity.
Manpreet Kaur, Dhaneshwar Kumar, +5 authors, Sharvan Sehrawat.
iScience, 2018 Nov 06; 9. PMID: 30388704    Free PMC article.
Linking single-cell measurements of mass, growth rate, and gene expression.
Robert J Kimmerling, Sanjay M Prakadan, +10 authors, Scott R Manalis.
Genome Biol, 2018 Nov 30; 19(1). PMID: 30482222    Free PMC article.
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming.
Alexandre P Bénéchet, Giorgia De Simone, +25 authors, Matteo Iannacone.
Nature, 2019 Oct 05; 574(7777). PMID: 31582858    Free PMC article.
Highly Cited.
Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality.
Mohit Sachdeva, Brian W Busser, +9 authors, Julien Valton.
Nat Commun, 2019 Nov 15; 10(1). PMID: 31723132    Free PMC article.
Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function.
Cansu Yerinde, Britta Siegmund, Rainer Glauben, Carl Weidinger.
Front Immunol, 2019 Dec 19; 10. PMID: 31849941    Free PMC article.
Activation of the Unfolded Protein Response Pathway in Cytotoxic T Cells: A Comparison Between in vitro Stimulation, Infection, and the Tumor Microenvironment.
Samuel R Kerr, Samuel G Katz.
Yale J Biol Med, 2019 Dec 24; 92(4). PMID: 31866782    Free PMC article.
Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions.
Efthymia Vokali, Shann S Yu, +9 authors, Melody A Swartz.
Nat Commun, 2020 Jan 29; 11(1). PMID: 31988323    Free PMC article.
[Oxidized low-density lipoprotein modulates differentiation of murine memory CD8+ T cell subpopulations].
Hua Zheng, Ze-Hang Lin, +3 authors, Sha Wu.
Nan Fang Yi Ke Da Xue Xue Bao, 2017 Aug 13; 37(8). PMID: 28801292    Free PMC article.
HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.
Tinashe E Nyanhete, Alyse L Frisbee, +12 authors, Georgia D Tomaras.
Sci Rep, 2019 Jul 17; 9(1). PMID: 31308388    Free PMC article.
CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1.
Xiangnan Du, Patricia de Almeida, +12 authors, Eugene Y Chiang.
Proc Natl Acad Sci U S A, 2018 Dec 07; 115(50). PMID: 30504141    Free PMC article.
Aging of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing.
Bennett Davenport, Jens Eberlein, +10 authors, Dirk Homann.
J Immunol, 2018 Dec 16; 202(2). PMID: 30552164    Free PMC article.
Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells.
Patrick L Collins, Marina Cella, +6 authors, Marco Colonna.
Cell, 2019 Jan 01; 176(1-2). PMID: 30595449    Free PMC article.
Highly Cited.
Expression of novel long noncoding RNAs defines virus-specific effector and memory CD8+ T cells.
William H Hudson, Nataliya Prokhnevska, +4 authors, Haydn T Kissick.
Nat Commun, 2019 Jan 16; 10(1). PMID: 30643116    Free PMC article.
Enhancer Associated Long Non-coding RNA Transcription and Gene Regulation in Experimental Models of Rickettsial Infection.
Imran H Chowdhury, Hema P Narra, +3 authors, Sanjeev K Sahni.
Front Immunol, 2019 Jan 29; 9. PMID: 30687302    Free PMC article.
NR4A transcription factors limit CAR T cell function in solid tumours.
Joyce Chen, Isaac F López-Moyado, +6 authors, Anjana Rao.
Nature, 2019 Mar 01; 567(7749). PMID: 30814732    Free PMC article.
Highly Cited.
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.
Orr-El Weizman, Eric Song, +8 authors, Timothy E O'Sullivan.
Nat Immunol, 2019 Jul 03; 20(8). PMID: 31263280    Free PMC article.
Highly Cited.
Comprehensive Characterization of a Next-Generation Antiviral T-Cell Product and Feasibility for Application in Immunosuppressed Transplant Patients.
Leila Amini, Tino Vollmer, +7 authors, Michael Schmueck-Henneresse.
Front Immunol, 2019 Jun 14; 10. PMID: 31191530    Free PMC article.
Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation.
Zhengqi Wang, Tamisha Y Vaughan, +11 authors, Kevin D Bunting.
Front Immunol, 2019 Apr 03; 10. PMID: 30936879    Free PMC article.
Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells.
Dhaneshwar Kumar, Sharvan Sehrawat.
Front Immunol, 2019 Jul 30; 10. PMID: 31354707    Free PMC article.
Stability and flexibility in chromatin structure and transcription underlies memory CD8 T-cell differentiation.
Huitian Diao, Matthew Pipkin.
F1000Res, 2019 Aug 27; 8. PMID: 31448086    Free PMC article.
The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans.
John L Johnson, Rebecca L Rosenthal, +21 authors, Michael P Cancro.
Immunity, 2020 May 01; 52(5). PMID: 32353250    Free PMC article.
Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.
Rong En Tay, Olamide Olawoyin, +9 authors, Kai W Wucherpfennig.
J Exp Med, 2020 May 07; 217(7). PMID: 32374402    Free PMC article.
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy.
Ting Zhou, William Damsky, +10 authors, Aaron M Ring.
Nature, 2020 Jun 26; 583(7817). PMID: 32581358    Free PMC article.
M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.
Eva M Garrido-Martin, Toby W P Mellows, +13 authors, Tilman Sanchez-Elsner.
J Immunother Cancer, 2020 Jul 24; 8(2). PMID: 32699181    Free PMC article.
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant.
Bram Van Den Eeckhout, Lien Van Hoecke, +7 authors, Sarah Gerlo.
NPJ Vaccines, 2020 Jul 28; 5(1). PMID: 32714571    Free PMC article.
KLRG1+ Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
Kristin R Renkema, Matthew A Huggins, +3 authors, Sara E Hamilton.
J Immunol, 2020 Jul 03; 205(4). PMID: 32611727    Free PMC article.
Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells.
Jens Eberlein, Bennett Davenport, +7 authors, Dirk Homann.
J Immunol, 2020 Sep 20; 205(8). PMID: 32948687    Free PMC article.
Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3.
Livia Odagiu, Salix Boulet, +3 authors, Nathalie Labrecque.
Proc Natl Acad Sci U S A, 2020 Sep 12; 117(39). PMID: 32913051    Free PMC article.
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies.
Travis K Hughes, Marc H Wadsworth, +12 authors, Alex K Shalek.
Immunity, 2020 Oct 15; 53(4). PMID: 33053333    Free PMC article.
Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.
J Justin Milner, Hongtuyet Nguyen, +8 authors, Ananda W Goldrath.
Proc Natl Acad Sci U S A, 2020 Sep 27; 117(41). PMID: 32978300    Free PMC article.
COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.
Benjamin J Schmiedel, Vivek Chandra, +6 authors, Pandurangan Vijayanand.
bioRxiv, 2020 Dec 11;. PMID: 33299987    Free PMC article.
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Dietmar Herndler-Brandstetter, Harumichi Ishigame, +13 authors, Richard A Flavell.
Immunity, 2018 Apr 08; 48(4). PMID: 29625895    Free PMC article.
Highly Cited.
The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.
Dapeng Wang, Huitian Diao, +7 authors, Matthew E Pipkin.
Immunity, 2018 Apr 19; 48(4). PMID: 29669249    Free PMC article.
Highly Cited.
Comprehensive mapping of the human cytokine gene regulatory network.
Clarissa S Santoso, Zhaorong Li, +9 authors, Juan I Fuxman Bass.
Nucleic Acids Res, 2020 Nov 13; 48(21). PMID: 33179750    Free PMC article.
Down-regulation of EOMES drives T-cell exhaustion via abolishing EOMES-mediated repression of inhibitory receptors of T cells in liver cancer.
Hongwei He, Yong Yi, +4 authors, Shuangjian Qiu.
J Cell Mol Med, 2020 Dec 17; 25(1). PMID: 33325636    Free PMC article.

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Loss of the orphan nuclear receptor NR2F6 enhances CD8+ T-cell memory via IFN-γ.
Bojana Jakic, William J Olson, +6 authors, Natascha Hermann-Kleiter.
Cell Death Dis, 2021 Feb 17; 12(2). PMID: 33589606    Free PMC article.
Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology.
Livia Odagiu, Julia May, +2 authors, Nathalie Labrecque.
Front Endocrinol (Lausanne), 2021 Feb 19; 11. PMID: 33597928    Free PMC article.
Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
Mallory Paynich Murray, Isaac Engel, +9 authors, Mitchell Kronenberg.
Nat Commun, 2021 Mar 06; 12(1). PMID: 33664261    Free PMC article.
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment.
Kristen E Pauken, Osmaan Shahid, +18 authors, Meromit Singer.
J Exp Med, 2021 Mar 03; 218(4). PMID: 33651880    Free PMC article.
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.
Can Liu, Andrew J Martins, +27 authors, John S Tsang.
Cell, 2021 Mar 14; 184(7). PMID: 33713619    Free PMC article.
Roles of Macrophages in the Development and Treatment of Gut Inflammation.
Xuebing Han, Sujuan Ding, Hongmei Jiang, Gang Liu.
Front Cell Dev Biol, 2021 Mar 20; 9. PMID: 33738283    Free PMC article.
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates.
H Kay Chung, Bryan McDonald, Susan M Kaech.
J Exp Med, 2021 Mar 24; 218(4). PMID: 33755719    Free PMC article.
Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.
Alexandra Franziska Gülich, Ramona Rica, +12 authors, Shinya Sakaguchi.
Front Immunol, 2021 Apr 06; 12. PMID: 33815354    Free PMC article.
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids.
Chang H Kim.
Cell Mol Immunol, 2021 Apr 15; 18(5). PMID: 33850311    Free PMC article.
T resident helper cells promote humoral responses in the lung.
Nivedya Swarnalekha, David Schreiner, +7 authors, Carolyn G King.
Sci Immunol, 2021 Jan 10; 6(55). PMID: 33419790    Free PMC article.
Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia.
Isabel Jiménez, Bárbara Tazón-Vega, +15 authors, Francesc Bosch.
Biomark Res, 2021 May 22; 9(1). PMID: 34016160    Free PMC article.
Revisiting the gut-joint axis: links between gut inflammation and spondyloarthritis.
Eric Gracey, Lars Vereecke, +6 authors, Dirk Elewaut.
Nat Rev Rheumatol, 2020 Jul 15; 16(8). PMID: 32661321
Clinical Significance and Systematic Expression Analysis of the Thyroid Receptor Interacting Protein 13 (TRIP13) as Human Gliomas Biomarker.
Ssu-Han Chen, Hong-Han Lin, +2 authors, Dueng-Yuan Hueng.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34066132    Free PMC article.
The Role of ZEB2 in Human CD8 T Lymphocytes: Clinical and Cellular Immune Profiling in Mowat-Wilson Syndrome.
Katie Frith, C Mee Ling Munier, +7 authors, John James Zaunders.
Int J Mol Sci, 2021 Jun 03; 22(10). PMID: 34070208    Free PMC article.
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation.
Karen O Dixon, Marcin Tabaka, +7 authors, Vijay K Kuchroo.
Nature, 2021 Jun 11; 595(7865). PMID: 34108686    Free PMC article.
A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants.
Raul Vizcardo, S M Rafiqul Islam, +7 authors, Nicholas P Restifo.
J Vis Exp, 2019 Aug 27; (150). PMID: 31449236    Free PMC article.
Resident memory T cells in tumor-distant tissues fortify against metastasis formation.
Laura S Christian, Liuyang Wang, +4 authors, Qi-Jing Li.
Cell Rep, 2021 May 13; 35(6). PMID: 33979626    Free PMC article.
NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors.
Kirsty Ford, Christopher J Hanley, +16 authors, Gareth J Thomas.
Cancer Res, 2020 Mar 04; 80(9). PMID: 32122909    Free PMC article.
Interrogating in vivo T-cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting.
Ryan D Sheldon, Eric H Ma, +2 authors, Russell G Jones.
Nat Protoc, 2021 Aug 06; 16(9). PMID: 34349284
The epigenetic immunomodulator, HBI-8000, enhances the response and reverses resistance to checkpoint inhibitors.
Reid P Bissonnette, Rosemary M Cesario, +2 authors, Mireille Gillings.
BMC Cancer, 2021 Sep 01; 21(1). PMID: 34461854    Free PMC article.
Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy.
Gregory M Chen, Changya Chen, +11 authors, Kai Tan.
Cancer Discov, 2021 Apr 07; 11(9). PMID: 33820778    Free PMC article.
Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment.
Feiya Ma, Jensen Vayalil, +2 authors, Guangyong Peng.
J Immunother Cancer, 2021 Oct 14; 9(10). PMID: 34642246    Free PMC article.
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness.
Daniel Hirschhorn, Allison Betof Warner, +11 authors, Jedd D Wolchok.
JCI Insight, 2021 Oct 23; 6(20). PMID: 34676831    Free PMC article.
Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon.
Young-Jun Ju, Sung-Woo Lee, +4 authors, Jae-Ho Cho.
Nat Commun, 2021 Oct 20; 12(1). PMID: 34663827    Free PMC article.
Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function.
Mohammad Taheri, Dominik A Barth, +3 authors, Martin Pichler.
Front Immunol, 2021 Nov 23; 12. PMID: 34804042    Free PMC article.
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients.
Lisa Rausch, Konstantin Lutz, +14 authors, Thomas Brocker.
J Extracell Vesicles, 2021 Dec 03; 10(14). PMID: 34854246    Free PMC article.
Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming.
Xingyuan Zhai, Kai Liu, +12 authors, Nengming Xiao.
Sci Adv, 2021 Dec 04; 7(49). PMID: 34860557    Free PMC article.
Dissecting the Landscape of Activated CMV-Stimulated CD4+ T Cells in Humans by Linking Single-Cell RNA-Seq With T-Cell Receptor Sequencing.
Menghua Lyu, Shiyu Wang, +7 authors, Lei Tian.
Front Immunol, 2021 Dec 25; 12. PMID: 34950144    Free PMC article.
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.
Mauro Di Pilato, Raphael Kfuri-Rubens, +18 authors, Thorsten R Mempel.
Cell, 2021 Aug 04; 184(17). PMID: 34343496    Free PMC article.
Protein synthesis, degradation, and energy metabolism in T cell immunity.
Julia M Marchingo, Doreen A Cantrell.
Cell Mol Immunol, 2022 Jan 06; 19(3). PMID: 34983947    Free PMC article.
Transcriptional Analysis of Total CD8+ T Cells and CD8+CD45RA- Memory T Cells From Young and Old Healthy Blood Donors.
Georgiana Toma, Ioana Maria Lemnian, +2 authors, Barbara Seliger.
Front Immunol, 2022 Feb 15; 13. PMID: 35154123    Free PMC article.
Antiviral Activities of Group I Innate Lymphoid Cells.
Ramon A Lujan, Sophia M Vrba, Heather D Hickman.
J Mol Biol, 2021 Sep 26; 434(6). PMID: 34562465    Free PMC article.