Journal Article
. 2013 Feb; 14(4):404-12.
doi: 10.1038/ni.2536.

Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation

J Adam Best 1 David A Blair  Jamie Knell  Edward Yang  Viveka Mayya  Andrew Doedens  Michael L Dustin  Ananda W Goldrath  Immunological Genome Project Consortium  
Affiliations
  • PMID: 23396170
  •     35 References
  •     156 citations

Abstract

After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived memory CD8+ cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8+ effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8+ T cell immunity.

mTOR regulates memory CD8 T-cell differentiation.
Koichi Araki, Alexandra P Turner, +5 authors, Rafi Ahmed.
Nature, 2009 Jun 23; 460(7251). PMID: 19543266    Free PMC article.
Highly Cited.
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.
Emmanuel L Gautier, Tal Shay, +15 authors, Immunological Genome Consortium.
Nat Immunol, 2012 Oct 02; 13(11). PMID: 23023392    Free PMC article.
Highly Cited.
Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.
Peter Geserick, Frank Kaiser, +2 authors, Jens Zerrahn.
Int Immunol, 2004 Sep 08; 16(10). PMID: 15351786
Differing roles of inflammation and antigen in T cell proliferation and memory generation.
D H Busch, K M Kerksiek, E G Pamer.
J Immunol, 2001 Feb 07; 164(8). PMID: 10754299
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates.
Surojit Sarkar, Vandana Kalia, +3 authors, Rafi Ahmed.
J Exp Med, 2008 Mar 05; 205(3). PMID: 18316415    Free PMC article.
Highly Cited.
Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
Erika L Pearce, Matthew C Walsh, +5 authors, Yongwon Choi.
Nature, 2009 Jun 06; 460(7251). PMID: 19494812    Free PMC article.
Highly Cited.
Visualizing the functional diversification of CD8+ T cell responses in lymph nodes.
Hélène Beuneu, Fabrice Lemaître, +5 authors, Philippe Bousso.
Immunity, 2010 Sep 21; 33(3). PMID: 20850354
Distinct regulation of effector and memory T-cell differentiation.
Axel Kallies.
Immunol Cell Biol, 2008 Mar 26; 86(4). PMID: 18362944
Review.
Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.
Joshua J Obar, Evan R Jellison, +4 authors, Leo Lefrançois.
J Immunol, 2011 Oct 12; 187(10). PMID: 21987662    Free PMC article.
Highly Cited.
Transcriptional regulator Id2 mediates CD8+ T cell immunity.
Michael A Cannarile, Nicholas A Lind, +6 authors, Ananda W Goldrath.
Nat Immunol, 2006 Nov 07; 7(12). PMID: 17086188
Highly Cited.
Initial T cell frequency dictates memory CD8+ T cell lineage commitment.
Amanda L Marzo, Kimberly D Klonowski, +3 authors, Leo Lefrançois.
Nat Immunol, 2005 Jul 19; 6(8). PMID: 16025119    Free PMC article.
Highly Cited.
In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors.
P Sacerdote, P Massi, A E Panerai, D Parolaro.
J Neuroimmunol, 2000 Sep 21; 109(2). PMID: 10996217
Shaping and reshaping CD8+ T-cell memory.
John T Harty, Vladimir P Badovinac.
Nat Rev Immunol, 2008 Jan 26; 8(2). PMID: 18219309
Highly Cited. Review.
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
W Nicholas Haining, Benjamin L Ebert, +13 authors, Todd R Golub.
J Immunol, 2008 Jul 22; 181(3). PMID: 18641323    Free PMC article.
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
Cliff Y Yang, J Adam Best, +10 authors, Ananda W Goldrath.
Nat Immunol, 2011 Nov 08; 12(12). PMID: 22057289    Free PMC article.
Highly Cited.
Molecular and functional profiling of memory CD8 T cell differentiation.
Susan M Kaech, Scott Hemby, Ellen Kersh, Rafi Ahmed.
Cell, 2003 Jan 16; 111(6). PMID: 12526810
Highly Cited.
Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory.
Pujya Agarwal, Arvind Raghavan, +4 authors, Matthew F Mescher.
J Immunol, 2009 Jul 14; 183(3). PMID: 19592655    Free PMC article.
Highly Cited.
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.
Gerritje J W van der Windt, Bart Everts, +5 authors, Erika L Pearce.
Immunity, 2011 Dec 31; 36(1). PMID: 22206904    Free PMC article.
Highly Cited.
Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2.
Takeshi Yamada, Chun Shik Park, Maksim Mamonkin, H Daniel Lacorazza.
Nat Immunol, 2009 May 05; 10(6). PMID: 19412182    Free PMC article.
Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1.
Carsten Gründemann, Monika Bauer, +8 authors, Hanspeter Pircher.
J Immunol, 2006 Jan 21; 176(3). PMID: 16424155
The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion.
Catherine Haluszczak, Adovi D Akue, +5 authors, Ross M Kedl.
J Exp Med, 2009 Feb 04; 206(2). PMID: 19188498    Free PMC article.
Highly Cited.
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.
Nikhil S Joshi, Weiguo Cui, +5 authors, Susan M Kaech.
Immunity, 2007 Aug 29; 27(2). PMID: 17723218    Free PMC article.
Highly Cited.
Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets.
Katharina M Huster, Verena Busch, +4 authors, Dirk H Busch.
Proc Natl Acad Sci U S A, 2004 Mar 27; 101(15). PMID: 15044705    Free PMC article.
Highly Cited.
The role of alpha E beta 7 integrin (CD103) and E-cadherin in epidermotropism in cutaneous T-cell lymphoma.
S B Dietz, D Whitaker-Menezes, S R Lessin.
J Cutan Pathol, 1996 Aug 01; 23(4). PMID: 8864917
Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells.
J M Grayson, A J Zajac, J D Altman, R Ahmed.
J Immunol, 2001 Feb 07; 164(8). PMID: 10754284
Highly Cited.
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.
Susan M Kaech, Joyce T Tan, +3 authors, Rafi Ahmed.
Nat Immunol, 2003 Nov 20; 4(12). PMID: 14625547
Highly Cited.
Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.
Louise M D'Cruz, Kristin Camfield Lind, +2 authors, Ananda W Goldrath.
Eur J Immunol, 2012 May 16; 42(8). PMID: 22585759    Free PMC article.
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.
Rachel L Rutishauser, Gislâine A Martins, +6 authors, Susan M Kaech.
Immunity, 2009 Aug 12; 31(2). PMID: 19664941    Free PMC article.
Highly Cited.
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo.
K S Schluns, W C Kieper, S C Jameson, L Lefrançois.
Nat Immunol, 2001 Mar 23; 1(5). PMID: 11062503
Highly Cited.
Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.
Vladimir P Badovinac, Jodie S Haring, John T Harty.
Immunity, 2007 Jun 09; 26(6). PMID: 17555991    Free PMC article.
Highly Cited.
Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just ROR gamma t anymore.
Mark S Sundrud, Anjana Rao.
Immunity, 2008 Jan 18; 28(1). PMID: 18199410
Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation.
Thomas C Wirth, Hai-Hui Xue, +4 authors, Vladimir P Badovinac.
Immunity, 2010 Jul 14; 33(1). PMID: 20619696    Free PMC article.
Highly Cited.
The Immunological Genome Project: networks of gene expression in immune cells.
Tracy S P Heng, Michio W Painter, Immunological Genome Project Consortium.
Nat Immunol, 2008 Sep 19; 9(10). PMID: 18800157
Highly Cited.
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection.
Joshua J Obar, Kamal M Khanna, Leo Lefrançois.
Immunity, 2008 May 24; 28(6). PMID: 18499487    Free PMC article.
Highly Cited.
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells.
S M Kaech, R Ahmed.
Nat Immunol, 2001 Apr 27; 2(5). PMID: 11323695    Free PMC article.
Highly Cited.
Immunological Genome Project and systems immunology.
Tal Shay, Joonsoo Kang.
Trends Immunol, 2013 May 02; 34(12). PMID: 23631936    Free PMC article.
Highly Cited. Review.
Differentiation of CD8 memory T cells depends on Foxo1.
Rodrigo Hess Michelini, Andrew L Doedens, Ananda W Goldrath, Stephen M Hedrick.
J Exp Med, 2013 May 29; 210(6). PMID: 23712431    Free PMC article.
Highly Cited.
Antigen availability determines CD8⁺ T cell-dendritic cell interaction kinetics and memory fate decisions.
Sarah E Henrickson, Mario Perro, +13 authors, Ulrich H von Andrian.
Immunity, 2013 Sep 24; 39(3). PMID: 24054328    Free PMC article.
Remembering one's ID/E-ntity: E/ID protein regulation of T cell memory.
Kyla D Omilusik, Laura A Shaw, Ananda W Goldrath.
Curr Opin Immunol, 2013 Oct 08; 25(5). PMID: 24094885    Free PMC article.
Review.
Lineage relationship of effector and memory T cells.
Nicholas P Restifo, Luca Gattinoni.
Curr Opin Immunol, 2013 Oct 24; 25(5). PMID: 24148236    Free PMC article.
Review.
Beyond the transcriptome: completion of act one of the Immunological Genome Project.
Charles C Kim, Lewis L Lanier.
Curr Opin Immunol, 2013 Oct 31; 25(5). PMID: 24168965    Free PMC article.
Review.
Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer.
M J Ward, S M Thirdborough, +14 authors, G J Thomas.
Br J Cancer, 2013 Oct 31; 110(2). PMID: 24169344    Free PMC article.
Highly Cited.
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.
Jia Xue, Susanne V Schmidt, +18 authors, Joachim L Schultze.
Immunity, 2014 Feb 18; 40(2). PMID: 24530056    Free PMC article.
Highly Cited.
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses.
Janilyn Arsenio, Boyko Kakaradov, +3 authors, John T Chang.
Nat Immunol, 2014 Mar 04; 15(4). PMID: 24584088    Free PMC article.
Highly Cited.
TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation.
Weiguo Cui, Nikhil S Joshi, +3 authors, Susan M Kaech.
J Immunol, 2014 Mar 25; 192(9). PMID: 24659688    Free PMC article.
Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.
Tim Raine, Jimmy Z Liu, +2 authors, Arthur Kaser.
Gut, 2014 May 07; 64(2). PMID: 24799394    Free PMC article.
Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy.
Adam J Litterman, David M Zellmer, +2 authors, David A Largaespada.
Cancer Immunol Res, 2014 May 24; 2(9). PMID: 24852944    Free PMC article.
c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells.
Chun Chou, Amelia K Pinto, +9 authors, Takeshi Egawa.
Nat Immunol, 2014 Jul 17; 15(9). PMID: 25029552    Free PMC article.
The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiation.
Simon M Gray, Susan M Kaech, Matthew M Staron.
Immunol Rev, 2014 Aug 16; 261(1). PMID: 25123283    Free PMC article.
Review.
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
Luzhou Xing, Zhenpeng Dai, +12 authors, Raphael Clynes.
Nat Med, 2014 Aug 19; 20(9). PMID: 25129481    Free PMC article.
Highly Cited.
In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.
Runqiang Chen, Simon Bélanger, +9 authors, Matthew E Pipkin.
Immunity, 2014 Aug 26; 41(2). PMID: 25148027    Free PMC article.
Intersection of population variation and autoimmunity genetics in human T cell activation.
Chun Jimmie Ye, Ting Feng, +14 authors, Christophe Benoist.
Science, 2014 Sep 13; 345(6202). PMID: 25214635    Free PMC article.
Highly Cited.
Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways.
Jeffrey A Ericson, Pierre Duffau, +5 authors, ImmGen Consortium.
PLoS One, 2014 Oct 04; 9(10). PMID: 25279834    Free PMC article.
Molecular regulation of effector and memory T cell differentiation.
John T Chang, E John Wherry, Ananda W Goldrath.
Nat Immunol, 2014 Nov 15; 15(12). PMID: 25396352    Free PMC article.
Highly Cited. Review.
The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.
Ross B Fulton, Sara E Hamilton, +4 authors, Stephen C Jameson.
Nat Immunol, 2014 Nov 25; 16(1). PMID: 25419629    Free PMC article.
Highly Cited.
Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8(+) T cell differentiation.
Brendan E Russ, Moshe Olshanksy, +15 authors, Stephen J Turner.
Immunity, 2014 Dec 18; 41(5). PMID: 25517617    Free PMC article.
Highly Cited.
Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen.
Innocent Safeukui, Noé D Gomez, +16 authors, Kasturi Haldar.
mBio, 2015 Jan 22; 6(1). PMID: 25604792    Free PMC article.
Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling.
James M Billingsley, Premeela A Rajakumar, +10 authors, R Paul Johnson.
PLoS Pathog, 2015 Mar 15; 11(3). PMID: 25768938    Free PMC article.
Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape.
Joseph G Crompton, Manikandan Narayanan, +14 authors, Nicholas P Restifo.
Cell Mol Immunol, 2015 Apr 29; 13(4). PMID: 25914936    Free PMC article.
In vivo RNAi screens: concepts and applications.
Shane Crotty, Matthew E Pipkin.
Trends Immunol, 2015 May 06; 36(5). PMID: 25937561    Free PMC article.
Review.
IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity.
Guoliang Cui, Matthew M Staron, +4 authors, Susan M Kaech.
Cell, 2015 May 11; 161(4). PMID: 25957683    Free PMC article.
Highly Cited.
mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.
Daisuke Ito, Satoshi Nojima, +17 authors, Atsushi Kumanogoh.
J Immunol, 2015 Jun 28; 195(3). PMID: 26116513    Free PMC article.
Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes.
Gavin C Preston, Linda V Sinclair, +6 authors, Doreen A Cantrell.
EMBO J, 2015 Jul 03; 34(15). PMID: 26136212    Free PMC article.
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Brian J Laidlaw, Weiguo Cui, +8 authors, Susan M Kaech.
Nat Immunol, 2015 Jul 07; 16(8). PMID: 26147684    Free PMC article.
Highly Cited.
Early Effector CD8 T Cells Display Plasticity in Populating the Short-Lived Effector and Memory-Precursor Pools Following Bacterial or Viral Infection.
Courtney R Plumlee, Joshua J Obar, +4 authors, Kamal M Khanna.
Sci Rep, 2015 Jul 21; 5. PMID: 26191658    Free PMC article.
T cell metabolism drives immunity.
Michael D Buck, David O'Sullivan, Erika L Pearce.
J Exp Med, 2015 Aug 12; 212(9). PMID: 26261266    Free PMC article.
Highly Cited. Review.
Metabolic regulation of T cell differentiation and function.
Benjamin V Park, Fan Pan.
Mol Immunol, 2015 Aug 19; 68(2 Pt C). PMID: 26277275    Free PMC article.
Review.
Functional classification of memory CD8(+) T cells by CX3CR1 expression.
Jan P Böttcher, Marc Beyer, +19 authors, Percy A Knolle.
Nat Commun, 2015 Sep 26; 6. PMID: 26404698    Free PMC article.
Highly Cited.
A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection.
Thomas C Greenough, Juerg R Straubhaar, +6 authors, Katherine F Luzuriaga.
J Immunol, 2015 Sep 30; 195(9). PMID: 26416268    Free PMC article.
Asymmetric Cell Division in T Lymphocyte Fate Diversification.
Janilyn Arsenio, Patrick J Metz, John T Chang.
Trends Immunol, 2015 Oct 18; 36(11). PMID: 26474675    Free PMC article.
Review.
Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.
Matthew D Martin, Marie T Kim, +4 authors, Vladimir P Badovinac.
PLoS Pathog, 2015 Oct 21; 11(10). PMID: 26485703    Free PMC article.
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.
Kyla D Omilusik, J Adam Best, +14 authors, Ananda W Goldrath.
J Exp Med, 2015 Oct 28; 212(12). PMID: 26503445    Free PMC article.
Highly Cited.
The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.
Claudia X Dominguez, Robert A Amezquita, +4 authors, Susan M Kaech.
J Exp Med, 2015 Oct 28; 212(12). PMID: 26503446    Free PMC article.
Highly Cited.
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.
Douglas C Palmer, Geoffrey C Guittard, +17 authors, Nicholas P Restifo.
J Exp Med, 2015 Nov 04; 212(12). PMID: 26527801    Free PMC article.
The cytotoxic T cell proteome and its shaping by the kinase mTOR.
Jens L Hukelmann, Karen E Anderson, +6 authors, Doreen A Cantrell.
Nat Immunol, 2015 Nov 10; 17(1). PMID: 26551880    Free PMC article.
Highly Cited.
Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells.
J Cao, X Zhang, +11 authors, J Zhang.
Cell Death Dis, 2015 Nov 20; 6. PMID: 26583325    Free PMC article.
The Timing of T Cell Priming and Cycling.
Reinhard Obst.
Front Immunol, 2015 Nov 26; 6. PMID: 26594213    Free PMC article.
Review.
Regulatory T cell memory.
Michael D Rosenblum, Sing Sing Way, Abul K Abbas.
Nat Rev Immunol, 2015 Dec 22; 16(2). PMID: 26688349    Free PMC article.
Highly Cited. Review.
C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection.
Mohammad Haque, Jianyong Song, +8 authors, Jianxun Song.
Open Biol, 2016 Jan 23; 6(1). PMID: 26791245    Free PMC article.
A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.
Yuan Tian, Maureen A Cox, +3 authors, Allan J Zajac.
J Immunol, 2016 Jan 31; 196(5). PMID: 26826252    Free PMC article.
Big Data Offers Novel Insights for Oncolytic Virus Immunotherapy.
Stephanie L Swift, David F Stojdl.
Viruses, 2016 Feb 11; 8(2). PMID: 26861383    Free PMC article.
Review.
A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology.
Jie Liu, Elias K Haddad, +5 authors, Barney S Graham.
PLoS Pathog, 2016 Mar 05; 12(3). PMID: 26943673    Free PMC article.
A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.
Annie Xin, Frederick Masson, +16 authors, Axel Kallies.
Nat Immunol, 2016 Mar 08; 17(4). PMID: 26950239    Free PMC article.
Highly Cited.
The DNA methylation profile of activated human natural killer cells.
John K Wiencke, Rondi Butler, +6 authors, Karl T Kelsey.
Epigenetics, 2016 Mar 12; 11(5). PMID: 26967308    Free PMC article.
Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy.
Vita Golubovskaya, Lijun Wu.
Cancers (Basel), 2016 Mar 22; 8(3). PMID: 26999211    Free PMC article.
Highly Cited. Review.
Unique human immune signature of Ebola virus disease in Guinea.
Paula Ruibal, Lisa Oestereich, +84 authors, César Muñoz-Fontela.
Nature, 2016 May 07; 533(7601). PMID: 27147028    Free PMC article.
Highly Cited.
Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.
Pranay Dogra, Hazem E Ghoneim, Hossam A Abdelsamed, Ben Youngblood.
Eur J Immunol, 2016 May 28; 46(7). PMID: 27230488    Free PMC article.
Review.
IL-21 and T Cell Differentiation: Consider the Context.
Yuan Tian, Allan J Zajac.
Trends Immunol, 2016 Jul 09; 37(8). PMID: 27389961    Free PMC article.
Review.
Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance.
Andrew L Doedens, Mark P Rubinstein, +6 authors, Ananda W Goldrath.
Cancer Immunol Res, 2016 Aug 04; 4(9). PMID: 27485135    Free PMC article.
ADAGE-Based Integration of Publicly Available Pseudomonas aeruginosa Gene Expression Data with Denoising Autoencoders Illuminates Microbe-Host Interactions.
Jie Tan, John H Hammond, Deborah A Hogan, Casey S Greene.
mSystems, 2016 Nov 09; 1(1). PMID: 27822512    Free PMC article.
Convergence of Innate and Adaptive Immunity during Human Aging.
Branca I Pereira, Arne N Akbar.
Front Immunol, 2016 Nov 22; 7. PMID: 27867379    Free PMC article.
Review.
Immune signatures of protective spleen memory CD8 T cells.
Lilia Brinza, Sophia Djebali, +17 authors, Jacqueline Marvel.
Sci Rep, 2016 Nov 25; 6. PMID: 27883012    Free PMC article.
Dynamic Changes in Chromatin Accessibility Occur in CD8+ T Cells Responding to Viral Infection.
James P Scott-Browne, Isaac F López-Moyado, +4 authors, Renata M Pereira.
Immunity, 2016 Dec 13; 45(6). PMID: 27939672    Free PMC article.
Highly Cited.
CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections.
Bing He, Shaojun Xing, +10 authors, Hai-Hui Xue.
Immunity, 2016 Dec 18; 45(6). PMID: 27986453    Free PMC article.
IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation.
Julia E Rood, Scott W Canna, +2 authors, Edward M Behrens.
J Leukoc Biol, 2016 Dec 31; 101(4). PMID: 28034913    Free PMC article.
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Selma Tuzlak, Robyn L Schenk, +7 authors, Marco J Herold.
Cell Death Differ, 2017 Jan 14; 24(3). PMID: 28085151    Free PMC article.
Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment.
Frederick S Varn, Yue Wang, +2 authors, Chao Cheng.
Cancer Res, 2017 Jan 28; 77(6). PMID: 28126714    Free PMC article.
Highly Cited.
Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing.
Boyko Kakaradov, Janilyn Arsenio, +11 authors, Gene W Yeo.
Nat Immunol, 2017 Feb 22; 18(4). PMID: 28218746    Free PMC article.
Highly Cited.
Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties.
Anangi Balasiddaiah, Haleh Davanian, +7 authors, Margaret Chen.
J Virol, 2017 Feb 24; 91(9). PMID: 28228595    Free PMC article.
Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.
Bingfei Yu, Kai Zhang, +9 authors, Ananda W Goldrath.
Nat Immunol, 2017 Mar 14; 18(5). PMID: 28288100    Free PMC article.
Highly Cited.
Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency.
Simon M Gray, Robert A Amezquita, +2 authors, Susan M Kaech.
Immunity, 2017 Apr 16; 46(4). PMID: 28410989    Free PMC article.
Highly Cited.
Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments.
Michael I Robson, Jose I de Las Heras, +3 authors, Eric C Schirmer.
Genome Res, 2017 Apr 21; 27(7). PMID: 28424353    Free PMC article.
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
Tizong Miao, Alistair L J Symonds, +6 authors, Ping Wang.
J Exp Med, 2017 May 11; 214(6). PMID: 28487311    Free PMC article.
Chromatin states define tumour-specific T cell dysfunction and reprogramming.
Mary Philip, Lauren Fairchild, +11 authors, Andrea Schietinger.
Nature, 2017 May 18; 545(7655). PMID: 28514453    Free PMC article.
Highly Cited.
Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.
Benjamin A Olenchock, Jeffrey C Rathmell, Matthew G Vander Heiden.
Immunity, 2017 May 18; 46(5). PMID: 28514672    Free PMC article.
Highly Cited. Review.
Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity.
Anthony T Phan, Ananda W Goldrath, Christopher K Glass.
Immunity, 2017 May 18; 46(5). PMID: 28514673    Free PMC article.
Highly Cited. Review.
Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections.
Eleonora Cimini, Domenico Viola, +42 authors, Chiara Agrati.
PLoS Negl Trop Dis, 2017 May 31; 11(5). PMID: 28558022    Free PMC article.
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Qiang Shan, Zhouhao Zeng, +13 authors, Hai-Hui Xue.
Nat Immunol, 2017 Jun 13; 18(8). PMID: 28604718    Free PMC article.
Highly Cited.
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.
Anusha-Preethi Ganesan, James Clarke, +14 authors, Christian H Ottensmeier.
Nat Immunol, 2017 Jun 20; 18(8). PMID: 28628092    Free PMC article.
Highly Cited.
CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation.
Holger Lingel, Josef Wissing, +7 authors, Monika C Brunner-Weinzierl.
Cell Death Differ, 2017 Jun 24; 24(10). PMID: 28644433    Free PMC article.
Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
Alexandria C Wells, Keith A Daniels, +7 authors, Leonid A Pobezinsky.
Elife, 2017 Jul 25; 6. PMID: 28737488    Free PMC article.
Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
Hyun Mu Shin, Varun N Kapoor, +9 authors, Leslie J Berg.
PLoS Pathog, 2017 Aug 23; 13(8). PMID: 28827827    Free PMC article.
The spectrum of T cell metabolism in health and disease.
Glenn R Bantug, Lorenzo Galluzzi, Guido Kroemer, Christoph Hess.
Nat Rev Immunol, 2017 Sep 26; 18(1). PMID: 28944771
Highly Cited. Review.
FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity.
Arnaud Delpoux, Chen-Yen Lai, Stephen M Hedrick, Andrew L Doedens.
Proc Natl Acad Sci U S A, 2017 Oct 05; 114(42). PMID: 28973925    Free PMC article.
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.
J Justin Milner, Clara Toma, +10 authors, Ananda W Goldrath.
Nature, 2017 Dec 07; 552(7684). PMID: 29211713    Free PMC article.
Highly Cited.
Redirection to the bone marrow improves T cell persistence and antitumor functions.
Anjum B Khan, Ben Carpenter, +19 authors, Ronjon Chakraverty.
J Clin Invest, 2018 Feb 28; 128(5). PMID: 29485974    Free PMC article.
Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease.
Pedro Santos E Sousa, Séverine Ciré, +15 authors, Ronjon Chakraverty.
JCI Insight, 2018 Mar 09; 3(5). PMID: 29515032    Free PMC article.
Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.
Raul Vizcardo, Nicholas D Klemen, +20 authors, Nicholas P Restifo.
Cell Rep, 2018 Mar 22; 22(12). PMID: 29562175    Free PMC article.
Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division.
Armelle Bohineust, Zacarias Garcia, +2 authors, Philippe Bousso.
J Exp Med, 2018 Mar 29; 215(5). PMID: 29588347    Free PMC article.
Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy.
Frederick S Varn, Laura J Tafe, Christopher I Amos, Chao Cheng.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872556    Free PMC article.
Prolonged Evolution of Virus-Specific Memory T Cell Immunity after Severe Avian Influenza A (H7N9) Virus Infection.
Min Zhao, Junbo Chen, +16 authors, Hongjie Yu.
J Virol, 2018 Jun 22; 92(17). PMID: 29925664    Free PMC article.
Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells.
Debra K Newman, Guoping Fu, +7 authors, Matthew J Riese.
J Leukoc Biol, 2018 Aug 01; 104(5). PMID: 30063264    Free PMC article.
B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation.
Mark D Singh, Minjian Ni, +2 authors, Daniel J Campbell.
J Exp Med, 2018 Aug 11; 215(9). PMID: 30093532    Free PMC article.
Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity.
Manpreet Kaur, Dhaneshwar Kumar, +5 authors, Sharvan Sehrawat.
iScience, 2018 Nov 06; 9. PMID: 30388704    Free PMC article.
Linking single-cell measurements of mass, growth rate, and gene expression.
Robert J Kimmerling, Sanjay M Prakadan, +10 authors, Scott R Manalis.
Genome Biol, 2018 Nov 30; 19(1). PMID: 30482222    Free PMC article.
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming.
Alexandre P Bénéchet, Giorgia De Simone, +25 authors, Matteo Iannacone.
Nature, 2019 Oct 05; 574(7777). PMID: 31582858    Free PMC article.
Highly Cited.
Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality.
Mohit Sachdeva, Brian W Busser, +9 authors, Julien Valton.
Nat Commun, 2019 Nov 15; 10(1). PMID: 31723132    Free PMC article.
Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function.
Cansu Yerinde, Britta Siegmund, Rainer Glauben, Carl Weidinger.
Front Immunol, 2019 Dec 19; 10. PMID: 31849941    Free PMC article.
Review.
Activation of the Unfolded Protein Response Pathway in Cytotoxic T Cells: A Comparison Between in vitro Stimulation, Infection, and the Tumor Microenvironment.
Samuel R Kerr, Samuel G Katz.
Yale J Biol Med, 2019 Dec 24; 92(4). PMID: 31866782    Free PMC article.
Review.
Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions.
Efthymia Vokali, Shann S Yu, +9 authors, Melody A Swartz.
Nat Commun, 2020 Jan 29; 11(1). PMID: 31988323    Free PMC article.
[Oxidized low-density lipoprotein modulates differentiation of murine memory CD8+ T cell subpopulations].
Hua Zheng, Ze-Hang Lin, +3 authors, Sha Wu.
Nan Fang Yi Ke Da Xue Xue Bao, 2017 Aug 13; 37(8). PMID: 28801292    Free PMC article.
HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.
Tinashe E Nyanhete, Alyse L Frisbee, +12 authors, Georgia D Tomaras.
Sci Rep, 2019 Jul 17; 9(1). PMID: 31308388    Free PMC article.
CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1.
Xiangnan Du, Patricia de Almeida, +12 authors, Eugene Y Chiang.
Proc Natl Acad Sci U S A, 2018 Dec 07; 115(50). PMID: 30504141    Free PMC article.
Aging of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing.
Bennett Davenport, Jens Eberlein, +10 authors, Dirk Homann.
J Immunol, 2018 Dec 16; 202(2). PMID: 30552164    Free PMC article.
Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells.
Patrick L Collins, Marina Cella, +6 authors, Marco Colonna.
Cell, 2019 Jan 01; 176(1-2). PMID: 30595449    Free PMC article.
Highly Cited.
Expression of novel long noncoding RNAs defines virus-specific effector and memory CD8+ T cells.
William H Hudson, Nataliya Prokhnevska, +4 authors, Haydn T Kissick.
Nat Commun, 2019 Jan 16; 10(1). PMID: 30643116    Free PMC article.
Enhancer Associated Long Non-coding RNA Transcription and Gene Regulation in Experimental Models of Rickettsial Infection.
Imran H Chowdhury, Hema P Narra, +3 authors, Sanjeev K Sahni.
Front Immunol, 2019 Jan 29; 9. PMID: 30687302    Free PMC article.
NR4A transcription factors limit CAR T cell function in solid tumours.
Joyce Chen, Isaac F López-Moyado, +6 authors, Anjana Rao.
Nature, 2019 Mar 01; 567(7749). PMID: 30814732    Free PMC article.
Highly Cited.
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.
Orr-El Weizman, Eric Song, +8 authors, Timothy E O'Sullivan.
Nat Immunol, 2019 Jul 03; 20(8). PMID: 31263280    Free PMC article.
Highly Cited.
Comprehensive Characterization of a Next-Generation Antiviral T-Cell Product and Feasibility for Application in Immunosuppressed Transplant Patients.
Leila Amini, Tino Vollmer, +7 authors, Michael Schmueck-Henneresse.
Front Immunol, 2019 Jun 14; 10. PMID: 31191530    Free PMC article.
Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation.
Zhengqi Wang, Tamisha Y Vaughan, +11 authors, Kevin D Bunting.
Front Immunol, 2019 Apr 03; 10. PMID: 30936879    Free PMC article.
Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells.
Dhaneshwar Kumar, Sharvan Sehrawat.
Front Immunol, 2019 Jul 30; 10. PMID: 31354707    Free PMC article.
Stability and flexibility in chromatin structure and transcription underlies memory CD8 T-cell differentiation.
Huitian Diao, Matthew Pipkin.
F1000Res, 2019 Aug 27; 8. PMID: 31448086    Free PMC article.
Review.
The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans.
John L Johnson, Rebecca L Rosenthal, +21 authors, Michael P Cancro.
Immunity, 2020 May 01; 52(5). PMID: 32353250    Free PMC article.
Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.
Rong En Tay, Olamide Olawoyin, +9 authors, Kai W Wucherpfennig.
J Exp Med, 2020 May 07; 217(7). PMID: 32374402    Free PMC article.
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy.
Ting Zhou, William Damsky, +10 authors, Aaron M Ring.
Nature, 2020 Jun 26; 583(7817). PMID: 32581358    Free PMC article.
M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.
Eva M Garrido-Martin, Toby W P Mellows, +13 authors, Tilman Sanchez-Elsner.
J Immunother Cancer, 2020 Jul 24; 8(2). PMID: 32699181    Free PMC article.
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant.
Bram Van Den Eeckhout, Lien Van Hoecke, +7 authors, Sarah Gerlo.
NPJ Vaccines, 2020 Jul 28; 5(1). PMID: 32714571    Free PMC article.
KLRG1+ Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
Kristin R Renkema, Matthew A Huggins, +3 authors, Sara E Hamilton.
J Immunol, 2020 Jul 03; 205(4). PMID: 32611727    Free PMC article.
Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells.
Jens Eberlein, Bennett Davenport, +7 authors, Dirk Homann.
J Immunol, 2020 Sep 20; 205(8). PMID: 32948687    Free PMC article.
Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3.
Livia Odagiu, Salix Boulet, +3 authors, Nathalie Labrecque.
Proc Natl Acad Sci U S A, 2020 Sep 12; 117(39). PMID: 32913051    Free PMC article.
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies.
Travis K Hughes, Marc H Wadsworth, +12 authors, Alex K Shalek.
Immunity, 2020 Oct 15; 53(4). PMID: 33053333    Free PMC article.
Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.
J Justin Milner, Hongtuyet Nguyen, +8 authors, Ananda W Goldrath.
Proc Natl Acad Sci U S A, 2020 Sep 27; 117(41). PMID: 32978300    Free PMC article.
COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.
Benjamin J Schmiedel, Vivek Chandra, +6 authors, Pandurangan Vijayanand.
bioRxiv, 2020 Dec 11;. PMID: 33299987    Free PMC article.
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Dietmar Herndler-Brandstetter, Harumichi Ishigame, +13 authors, Richard A Flavell.
Immunity, 2018 Apr 08; 48(4). PMID: 29625895    Free PMC article.
Highly Cited.
The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.
Dapeng Wang, Huitian Diao, +7 authors, Matthew E Pipkin.
Immunity, 2018 Apr 19; 48(4). PMID: 29669249    Free PMC article.
Highly Cited.
Comprehensive mapping of the human cytokine gene regulatory network.
Clarissa S Santoso, Zhaorong Li, +9 authors, Juan I Fuxman Bass.
Nucleic Acids Res, 2020 Nov 13; 48(21). PMID: 33179750    Free PMC article.
Down-regulation of EOMES drives T-cell exhaustion via abolishing EOMES-mediated repression of inhibitory receptors of T cells in liver cancer.
Hongwei He, Yong Yi, +4 authors, Shuangjian Qiu.
J Cell Mol Med, 2020 Dec 17; 25(1). PMID: 33325636    Free PMC article.

;. PMID: 33574336
Loss of the orphan nuclear receptor NR2F6 enhances CD8+ T-cell memory via IFN-γ.
Bojana Jakic, William J Olson, +6 authors, Natascha Hermann-Kleiter.
Cell Death Dis, 2021 Feb 17; 12(2). PMID: 33589606    Free PMC article.
Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology.
Livia Odagiu, Julia May, +2 authors, Nathalie Labrecque.
Front Endocrinol (Lausanne), 2021 Feb 19; 11. PMID: 33597928    Free PMC article.
Review.
Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
Mallory Paynich Murray, Isaac Engel, +9 authors, Mitchell Kronenberg.
Nat Commun, 2021 Mar 06; 12(1). PMID: 33664261    Free PMC article.
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment.
Kristen E Pauken, Osmaan Shahid, +18 authors, Meromit Singer.
J Exp Med, 2021 Mar 03; 218(4). PMID: 33651880    Free PMC article.
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.
Can Liu, Andrew J Martins, +27 authors, John S Tsang.
Cell, 2021 Mar 14; 184(7). PMID: 33713619    Free PMC article.
Roles of Macrophages in the Development and Treatment of Gut Inflammation.
Xuebing Han, Sujuan Ding, Hongmei Jiang, Gang Liu.
Front Cell Dev Biol, 2021 Mar 20; 9. PMID: 33738283    Free PMC article.
Review.
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates.
H Kay Chung, Bryan McDonald, Susan M Kaech.
J Exp Med, 2021 Mar 24; 218(4). PMID: 33755719    Free PMC article.
Review.
Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.
Alexandra Franziska Gülich, Ramona Rica, +12 authors, Shinya Sakaguchi.
Front Immunol, 2021 Apr 06; 12. PMID: 33815354    Free PMC article.
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids.
Chang H Kim.
Cell Mol Immunol, 2021 Apr 15; 18(5). PMID: 33850311    Free PMC article.
Review.
T resident helper cells promote humoral responses in the lung.
Nivedya Swarnalekha, David Schreiner, +7 authors, Carolyn G King.
Sci Immunol, 2021 Jan 10; 6(55). PMID: 33419790    Free PMC article.
Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia.
Isabel Jiménez, Bárbara Tazón-Vega, +15 authors, Francesc Bosch.
Biomark Res, 2021 May 22; 9(1). PMID: 34016160    Free PMC article.
Revisiting the gut-joint axis: links between gut inflammation and spondyloarthritis.
Eric Gracey, Lars Vereecke, +6 authors, Dirk Elewaut.
Nat Rev Rheumatol, 2020 Jul 15; 16(8). PMID: 32661321
Review.
Clinical Significance and Systematic Expression Analysis of the Thyroid Receptor Interacting Protein 13 (TRIP13) as Human Gliomas Biomarker.
Ssu-Han Chen, Hong-Han Lin, +2 authors, Dueng-Yuan Hueng.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34066132    Free PMC article.
The Role of ZEB2 in Human CD8 T Lymphocytes: Clinical and Cellular Immune Profiling in Mowat-Wilson Syndrome.
Katie Frith, C Mee Ling Munier, +7 authors, John James Zaunders.
Int J Mol Sci, 2021 Jun 03; 22(10). PMID: 34070208    Free PMC article.
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation.
Karen O Dixon, Marcin Tabaka, +7 authors, Vijay K Kuchroo.
Nature, 2021 Jun 11; 595(7865). PMID: 34108686    Free PMC article.
A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants.
Raul Vizcardo, S M Rafiqul Islam, +7 authors, Nicholas P Restifo.
J Vis Exp, 2019 Aug 27; (150). PMID: 31449236    Free PMC article.
Resident memory T cells in tumor-distant tissues fortify against metastasis formation.
Laura S Christian, Liuyang Wang, +4 authors, Qi-Jing Li.
Cell Rep, 2021 May 13; 35(6). PMID: 33979626    Free PMC article.
NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors.
Kirsty Ford, Christopher J Hanley, +16 authors, Gareth J Thomas.
Cancer Res, 2020 Mar 04; 80(9). PMID: 32122909    Free PMC article.
Interrogating in vivo T-cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting.
Ryan D Sheldon, Eric H Ma, +2 authors, Russell G Jones.
Nat Protoc, 2021 Aug 06; 16(9). PMID: 34349284
The epigenetic immunomodulator, HBI-8000, enhances the response and reverses resistance to checkpoint inhibitors.
Reid P Bissonnette, Rosemary M Cesario, +2 authors, Mireille Gillings.
BMC Cancer, 2021 Sep 01; 21(1). PMID: 34461854    Free PMC article.
Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy.
Gregory M Chen, Changya Chen, +11 authors, Kai Tan.
Cancer Discov, 2021 Apr 07; 11(9). PMID: 33820778    Free PMC article.
Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment.
Feiya Ma, Jensen Vayalil, +2 authors, Guangyong Peng.
J Immunother Cancer, 2021 Oct 14; 9(10). PMID: 34642246    Free PMC article.
Review.
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness.
Daniel Hirschhorn, Allison Betof Warner, +11 authors, Jedd D Wolchok.
JCI Insight, 2021 Oct 23; 6(20). PMID: 34676831    Free PMC article.
Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon.
Young-Jun Ju, Sung-Woo Lee, +4 authors, Jae-Ho Cho.
Nat Commun, 2021 Oct 20; 12(1). PMID: 34663827    Free PMC article.
Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function.
Mohammad Taheri, Dominik A Barth, +3 authors, Martin Pichler.
Front Immunol, 2021 Nov 23; 12. PMID: 34804042    Free PMC article.
Review.
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients.
Lisa Rausch, Konstantin Lutz, +14 authors, Thomas Brocker.
J Extracell Vesicles, 2021 Dec 03; 10(14). PMID: 34854246    Free PMC article.
Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming.
Xingyuan Zhai, Kai Liu, +12 authors, Nengming Xiao.
Sci Adv, 2021 Dec 04; 7(49). PMID: 34860557    Free PMC article.
Dissecting the Landscape of Activated CMV-Stimulated CD4+ T Cells in Humans by Linking Single-Cell RNA-Seq With T-Cell Receptor Sequencing.
Menghua Lyu, Shiyu Wang, +7 authors, Lei Tian.
Front Immunol, 2021 Dec 25; 12. PMID: 34950144    Free PMC article.
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.
Mauro Di Pilato, Raphael Kfuri-Rubens, +18 authors, Thorsten R Mempel.
Cell, 2021 Aug 04; 184(17). PMID: 34343496    Free PMC article.
Protein synthesis, degradation, and energy metabolism in T cell immunity.
Julia M Marchingo, Doreen A Cantrell.
Cell Mol Immunol, 2022 Jan 06; 19(3). PMID: 34983947    Free PMC article.
Review.
Transcriptional Analysis of Total CD8+ T Cells and CD8+CD45RA- Memory T Cells From Young and Old Healthy Blood Donors.
Georgiana Toma, Ioana Maria Lemnian, +2 authors, Barbara Seliger.
Front Immunol, 2022 Feb 15; 13. PMID: 35154123    Free PMC article.
Antiviral Activities of Group I Innate Lymphoid Cells.
Ramon A Lujan, Sophia M Vrba, Heather D Hickman.
J Mol Biol, 2021 Sep 26; 434(6). PMID: 34562465    Free PMC article.
Review.