Molecular mechanisms of T cell co-stimulation and co-inhibition

Lieping Chen ¹, Dallas B Flies

Affiliations

¹ Department of Immunobiology and Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06519, USA. lieping.chen@yale.edu

PMID: 23470321
134 References
1062 citations

Abstract

Co-stimulatory and co-inhibitory receptors have a pivotal role in T cell biology, as they determine the functional outcome of T cell receptor (TCR) signalling. The classic definition of T cell co-stimulation continues to evolve through the identification of new co-stimulatory and co-inhibitory receptors, the biochemical characterization of their downstream signalling events and the delineation of their immunological functions. Notably, it has been recently appreciated that co-stimulatory and co-inhibitory receptors display great diversity in expression, structure and function, and that their functions are largely context dependent. Here, we focus on some of these emerging concepts and review the mechanisms through which T cell activation, differentiation and function is controlled by co-stimulatory and co-inhibitory receptors.

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Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. Lukas Baitsch, Amandine Legat, +11 authors, Daniel E Speiser. less PLoS One, 2012 Feb 22; 7(2). PMID: 22347406 Free PMC article. Highly Cited.
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. Loise M Francisco, Victor H Salinas, +4 authors, Arlene H Sharpe. less J Exp Med, 2009 Dec 17; 206(13). PMID: 20008522 Free PMC article. Highly Cited.
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Fang Zhao, Jennifer L Cannons, +2 authors, Mala Dutta, Gillian M Griffiths, Pamela L Schwartzberg. less Immunity, 2012 Jun 12; 36(6). PMID: 22683123 Free PMC article.
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. Debora Franceschini, Marino Paroli, +6 authors, Vincenzo Barnaba. less J Clin Invest, 2009 Feb 21; 119(3). PMID: 19229109 Free PMC article. Highly Cited.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom. less Science, 2011 Apr 09; 332(6029). PMID: 21474713 Free PMC article. Highly Cited.
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. Bertram Bengsch, Bianca Seigel, +5 authors, Robert Thimme. less PLoS Pathog, 2010 Jun 16; 6(6). PMID: 20548953 Free PMC article. Highly Cited.
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1. Shoba Amarnath, Carliann M Costanzo, +9 authors, Daniel H Fowler. less PLoS Biol, 2010 Feb 04; 8(2). PMID: 20126379 Free PMC article.
The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation. Marcos W Steinberg, Timothy C Cheung, Carl F Ware. Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017438 Free PMC article. Review.
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Manu Rangachari, Chen Zhu, +13 authors, Vijay K Kuchroo. less Nat Med, 2012 Aug 07; 18(9). PMID: 22863785 Free PMC article. Highly Cited.
Cell surface signaling molecules in the control of immune responses: a tide model. Yuwen Zhu, Sheng Yao, Lieping Chen. Immunity, 2011 Apr 23; 34(4). PMID: 21511182 Free PMC article. Review.
HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation. M L del Rio, C L Lucas, +2 authors, L Buhler, G Rayat, J I Rodriguez-Barbosa. less J Leukoc Biol, 2009 Dec 17; 87(2). PMID: 20007250 Review.
Transcription factor regulation of CD8+ T-cell memory and exhaustion. Jill M Angelosanto, E John Wherry. Immunol Rev, 2010 Jul 20; 236. PMID: 20636816 Review.
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. Kelly-Ann Sheppard, Lori J Fitz, +8 authors, Divya Chaudhary. less FEBS Lett, 2004 Sep 11; 574(1-3). PMID: 15358536 Highly Cited.
Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. Jennifer L Cannons, Julie Z Wu, +6 authors, Pamela L Schwartzberg. less J Immunol, 2010 Jul 30; 185(5). PMID: 20668219 Free PMC article.

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Host and microbial factors in regulation of T cells in the intestine. Chang H Kim. Front Immunol, 2013 Jun 19; 4. PMID: 23772228 Free PMC article.
Molecular insights for optimizing T cell receptor specificity against cancer. Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer. less Front Immunol, 2013 Jun 27; 4. PMID: 23801991 Free PMC article.
A co-stimulatory trap set by myeloid leukemia cells. Gunes Esendagli. Oncoimmunology, 2013 Jul 31; 2(6). PMID: 23894714 Free PMC article.
CD70 is downregulated by interaction with CD27. Mirela Kuka, Ivana Munitic, Maria Letizia Giardino Torchia, Jonathan D Ashwell. J Immunol, 2013 Aug 06; 191(5). PMID: 23913967 Free PMC article.
The great balancing act: regulation and fate of antiviral T-cell interactions. E Ashley Moseman, Dorian B McGavern. Immunol Rev, 2013 Aug 21; 255(1). PMID: 23947351 Free PMC article. Review.
Antigen and transforming growth factor Beta receptors contribute to long term functional and phenotypic heterogeneity of memory CD8 T cells. Yinghong Hu, Linda Cauley. Front Immunol, 2013 Aug 22; 4. PMID: 23964275 Free PMC article.
Paramyxovirus activation and inhibition of innate immune responses. Griffith D Parks, Martha A Alexander-Miller. J Mol Biol, 2013 Sep 24; 425(24). PMID: 24056173 Free PMC article. Review.
SOCS3 deletion in T lymphocytes suppresses development of chronic ocular inflammation via upregulation of CTLA-4 and expansion of regulatory T cells. Cheng-Rong Yu, Sung-Hye Kim, Rashid M Mahdi, Charles E Egwuagu. J Immunol, 2013 Oct 09; 191(10). PMID: 24101549 Free PMC article.
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. Paula D Bos, George Plitas, +2 authors, Dipayan Rudra, Sue Y Lee, Alexander Y Rudensky. less J Exp Med, 2013 Oct 16; 210(11). PMID: 24127486 Free PMC article. Highly Cited.
Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics. Sachin Gupta, James M Termini, Saravana Kanagavelu, Geoffrey W Stone. Immunol Res, 2013 Nov 08; 57(1-3). PMID: 24198065 Free PMC article. Review.
Emerging Co-signaling Networks in T Cell Immune Regulation. Keunok Jung, Inhak Choi. Immune Netw, 2013 Nov 08; 13(5). PMID: 24198743 Free PMC article. Review.
Induction and stability of the anergic phenotype in T cells. Rut Valdor, Fernando Macian. Semin Immunol, 2013 Nov 12; 25(4). PMID: 24211041 Free PMC article. Review.
Allogeneic T cell responses are regulated by a specific miRNA-mRNA network. Yaping Sun, Isao Tawara, +7 authors, Pavan Reddy. less J Clin Invest, 2013 Nov 13; 123(11). PMID: 24216511 Free PMC article.
Expanding role of T cells in acute kidney injury. Gilbert R Kinsey, Mark D Okusa. Curr Opin Nephrol Hypertens, 2013 Nov 16; 23(1). PMID: 24231312 Free PMC article. Review.
TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu. Andre Kunert, Trudy Straetemans, +4 authors, Reno Debets. less Front Immunol, 2013 Nov 23; 4. PMID: 24265631 Free PMC article. Review.
Design and development of therapies using chimeric antigen receptor-expressing T cells. Gianpietro Dotti, Stephen Gottschalk, Barbara Savoldo, Malcolm K Brenner. Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329793 Free PMC article. Highly Cited. Review.
Current advances in immunotherapy for pancreatic cancer. Jennifer N Uram, Dung T Le. Curr Probl Cancer, 2013 Dec 18; 37(5). PMID: 24331182 Free PMC article. Review.
T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. Kiera L Clayton, Matthew S Haaland, +4 authors, Mario A Ostrowski. less J Immunol, 2013 Dec 18; 192(2). PMID: 24337741 Free PMC article.
Prospects for therapeutic tolerance in humans. Kenneth F Baker, John D Isaacs. Curr Opin Rheumatol, 2014 Jan 01; 26(2). PMID: 24378931 Free PMC article. Review.
Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells. Amandine Legat, Daniel E Speiser, +2 authors, Hanspeter Pircher, Dietmar Zehn, Silvia A Fuertes Marraco. less Front Immunol, 2014 Jan 07; 4. PMID: 24391639 Free PMC article. Highly Cited.
Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly. Aurélie Le Page, Carl Fortin, +6 authors, Tamas Fülöp. less Cell Commun Signal, 2014 Jan 11; 12. PMID: 24405902 Free PMC article.
Hunting complex differential gene interaction patterns across molecular contexts. Mingzhou Song, Yang Zhang, +2 authors, Alexia J Katzaroff, Bruce A Edgar, Laura Buttitta. less Nucleic Acids Res, 2014 Feb 01; 42(7). PMID: 24482443 Free PMC article.
The new normal: immunomodulatory agents against sepsis immune suppression. Noelle A Hutchins, Jacqueline Unsinger, Richard S Hotchkiss, Alfred Ayala. Trends Mol Med, 2014 Feb 04; 20(4). PMID: 24485901 Free PMC article. Highly Cited. Review.
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis. Scott M Reba, Qing Li, +10 authors, Roxana E Rojas. less Eur J Immunol, 2014 Feb 06; 44(5). PMID: 24497180 Free PMC article.
Stochastic modelling of T-cell activation. Hannah Mayer, Anton Bovier. J Math Biol, 2014 Feb 07; 70(1-2). PMID: 24500058
Diverse macrophage populations mediate acute lung inflammation and resolution. Neil R Aggarwal, Landon S King, Franco R D'Alessio. Am J Physiol Lung Cell Mol Physiol, 2014 Feb 11; 306(8). PMID: 24508730 Free PMC article. Highly Cited. Review.
SA-4-1BBL as a novel adjuvant for the development of therapeutic cancer vaccines. Rajesh K Sharma, Esma S Yolcu, Haval Shirwan. Expert Rev Vaccines, 2014 Feb 14; 13(3). PMID: 24521311 Free PMC article. Review.
Cutaneous T cell lymphoma expresses immunosuppressive CD80 (B7-1) cell surface protein in a STAT5-dependent manner. Qian Zhang, Hong Yi Wang, +11 authors, Mariusz A Wasik. less J Immunol, 2014 Feb 14; 192(6). PMID: 24523507 Free PMC article.
Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection. Jacob V Gorman, Gabriel Starbeck-Miller, +4 authors, John D Colgan. less J Immunol, 2014 Feb 26; 192(7). PMID: 24567532 Free PMC article.
Infection biology: Nibbled to death. Nancy Guillén. Nature, 2014 Apr 11; 508(7497). PMID: 24717438
Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis. Kang-kang Liu, Qing-tong Wang, +3 authors, Wei Wei. less Acta Pharmacol Sin, 2014 Apr 15; 35(5). PMID: 24727939 Free PMC article.
Allergic sensitization: host-immune factors. Ronald van Ree, Lone Hummelshøj, +2 authors, Maud Plantinga, Lars K Poulsen, Emily Swindle. less Clin Transl Allergy, 2014 Apr 17; 4(1). PMID: 24735802 Free PMC article.
Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity. Dallas B Flies, Xue Han, +4 authors, Lieping Chen. less J Clin Invest, 2014 Apr 20; 124(5). PMID: 24743150 Free PMC article. Highly Cited.
Abatacept (cytotoxic T lymphocyte antigen 4-immunoglobulin) improves B cell function and regulatory T cell inhibitory capacity in rheumatoid arthritis patients non-responding to anti-tumour necrosis factor-α agents. A Picchianti Diamanti, M M Rosado, +6 authors, R Carsetti. less Clin Exp Immunol, 2014 Apr 30; 177(3). PMID: 24773026 Free PMC article.
Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells. Sachiko Hirosue, Efthymia Vokali, +7 authors, Melody A Swartz. less J Immunol, 2014 May 06; 192(11). PMID: 24795456 Free PMC article. Highly Cited.
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. Christian A Bauer, Edward Y Kim, +3 authors, Thorsten R Mempel. less J Clin Invest, 2014 May 09; 124(6). PMID: 24812664 Free PMC article. Highly Cited.
Monocyte-activation phenotypes are associated with biomarkers of inflammation and coagulation in chronic HIV infection. Eleanor M P Wilson, Amrit Singh, +10 authors, Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study) Investigators. less J Infect Dis, 2014 May 13; 210(9). PMID: 24813472 Free PMC article.
Initiation of an inflammatory response in resident intestinal lamina propria cells -use of a human organ culture model. Jutta Schröder-Braunstein, Judith Gras, +15 authors, Stefan Meuer. less PLoS One, 2014 May 21; 9(5). PMID: 24841635 Free PMC article.
What have we learned from cancer immunotherapy in the last 3 years? Paolo A Ascierto, Francesco M Marincola. J Transl Med, 2014 Jun 03; 12. PMID: 24886164 Free PMC article.
The development of endometrial hyperplasia in aged PD-1-deficient female mice. Guoning Guo, Hong Li, Dayan Cao, Yongwen Chen. Diagn Pathol, 2014 Jun 03; 9. PMID: 24886298 Free PMC article.
Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions. Tai Hato, Lipika Goyal, +2 authors, Tim F Greten, Dan G Duda, Andrew X Zhu. less Hepatology, 2014 Jun 11; 60(5). PMID: 24912948 Free PMC article. Highly Cited. Review.
The "Trojan Horse" approach to tumor immunotherapy: targeting the tumor microenvironment. Delia Nelson, Scott Fisher, Bruce Robinson. J Immunol Res, 2014 Jun 24; 2014. PMID: 24955376 Free PMC article. Review.
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Kristen N Pollizzi, Jonathan D Powell. Nat Rev Immunol, 2014 Jun 26; 14(7). PMID: 24962260 Free PMC article. Highly Cited. Review.
Induction of death receptor CD95 and co-stimulatory molecules CD80 and CD86 by meningococcal capsular polysaccharide-loaded vaccine nanoparticles. Ruhi V Ubale, Rikhav P Gala, Susu M Zughaier, Martin J D'Souza. AAPS J, 2014 Jul 02; 16(5). PMID: 24981893 Free PMC article.
TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells. Ellen J Beswick, Jameel R Johnson, +8 authors, Irina V Pinchuk. less J Immunol, 2014 Jul 30; 193(5). PMID: 25070848 Free PMC article.
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. KiBem Kim, Andrew D Skora, +8 authors, Shibin Zhou. less Proc Natl Acad Sci U S A, 2014 Jul 30; 111(32). PMID: 25071169 Free PMC article. Highly Cited.
Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. Yilin Cao, Jeffrey C Rathmell, Andrew N Macintyre. PLoS One, 2014 Aug 05; 9(8). PMID: 25090630 Free PMC article.
Integrative biology of T cell activation. Bernard Malissen, Claude Grégoire, Marie Malissen, Romain Roncagalli. Nat Immunol, 2014 Aug 20; 15(9). PMID: 25137453 Review.
In situ characterization of intrahepatic non-parenchymal cells in PSC reveals phenotypic patterns associated with disease severity. Lena Berglin, Annika Bergquist, +6 authors, Niklas K Björkström. less PLoS One, 2014 Aug 21; 9(8). PMID: 25141347 Free PMC article.
Changing faces in virology: the dutch shift from oncogenic to oncolytic viruses. Zineb Belcaid, Martine L M Lamfers, Victor W van Beusechem, Rob C Hoeben. Hum Gene Ther, 2014 Aug 22; 25(10). PMID: 25141764 Free PMC article. Review.
Peptides and peptidomimetics as immunomodulators. Ameya S Gokhale, Seetharama Satyanarayanajois. Immunotherapy, 2014 Sep 05; 6(6). PMID: 25186605 Free PMC article. Review.
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Hye Sun Kuehn, Weiming Ouyang, +33 authors, Gulbu Uzel. less Science, 2014 Sep 13; 345(6204). PMID: 25213377 Free PMC article. Highly Cited.
Associations between the cytotoxic T lymphocyte antigen 4 polymorphisms and risk of bone sarcomas. Changchun Fan, Xuechun Zhao, Zhixing Xu. Tumour Biol, 2014 Sep 19; 36(1). PMID: 25230787
CD4+ T cells promote the pathogenesis of Staphylococcus aureus pneumonia. Dane Parker, Chanelle L Ryan, +3 authors, Alice S Prince. less J Infect Dis, 2014 Sep 23; 211(5). PMID: 25240171 Free PMC article.
Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection. Kenneth H Ely, Mitsuo Matsuoka, +6 authors, Richard I Enelow. less PLoS One, 2014 Sep 25; 9(9). PMID: 25251060 Free PMC article.
T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? Daniel E Speiser, Daniel T Utzschneider, +3 authors, Dietmar Zehn. less Nat Rev Immunol, 2014 Sep 27; 14(11). PMID: 25257362 Highly Cited.
From bench to bedside: immunotherapy for prostate cancer. Brian Wan-Chi Tse, Lidija Jovanovic, +3 authors, Pamela Joan Russell. less Biomed Res Int, 2014 Oct 03; 2014. PMID: 25276838 Free PMC article. Review.
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice. Toshiyuki Yoshida, Takanori Iwata, +3 authors, Teruo Okano. less Genes Cells, 2014 Oct 10; 19(11). PMID: 25297509 Free PMC article.
T cell-macrophage interactions and granuloma formation in vasculitis. Marc Hilhorst, Tsuyoshi Shirai, +2 authors, Gerald Berry, Jörg J Goronzy, Cornelia M Weyand. less Front Immunol, 2014 Oct 14; 5. PMID: 25309534 Free PMC article. Review.
Bone Marrow Mesenchymal Stromal Cells Induce Proliferative, Cytokinic and Molecular Changes During the T Cell Response: The Importance of the IL-10/CD210 Axis. Mehdi Najar, Gordana Raicevic, +4 authors, Laurence Lagneaux. less Stem Cell Rev Rep, 2014 Oct 19; 11(3). PMID: 25326368
[Advances of PD-1/PD-L1 signaling pathway in immune escape and treatment for  non-small cell lung cancer]. Cheng Lin, Xiong Chen, +2 authors, Jingnan Liu, Yufang Huang, Xuenong Ou-Yang. less Zhongguo Fei Ai Za Zhi, 2014 Oct 25; 17(10). PMID: 25342040 Free PMC article. Review.
Transplantation: molecular phenotyping of T-cell-mediated rejection. Anita S Chong, David L Perkins. Nat Rev Nephrol, 2014 Oct 29; 10(12). PMID: 25347945 Free PMC article. Review.
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Limo Chen, Don L Gibbons, +27 authors, F Xiao-Feng Qin. less Nat Commun, 2014 Oct 29; 5. PMID: 25348003 Free PMC article. Highly Cited.
Liposomes as vaccine delivery systems: a review of the recent advances. Reto A Schwendener. Ther Adv Vaccines, 2014 Nov 05; 2(6). PMID: 25364509 Free PMC article. Highly Cited. Review.
Cognate CD4 T-cell licensing of dendritic cells heralds anti-cytomegalovirus CD8 T-cell immunity after human allogeneic umbilical cord blood transplantation. T W H Flinsenberg, L Spel, +11 authors, M Boes. less J Virol, 2014 Nov 08; 89(2). PMID: 25378489 Free PMC article.
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. Sarah Buchan, Teresa Manzo, +12 authors, Ronjon Chakraverty. less J Immunol, 2014 Nov 19; 194(1). PMID: 25404365 Free PMC article.
Soluble co-signaling molecules predict long-term graft outcome in kidney-transplanted patients. Susana G Melendreras, Pablo Martínez-Camblor, +7 authors, Beatriz Suárez-Álvarez. less PLoS One, 2014 Dec 06; 9(12). PMID: 25478957 Free PMC article.
B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease. Ruishu Deng, Kaniel Cassady, +6 authors, Defu Zeng. less J Immunol, 2014 Dec 10; 194(2). PMID: 25488990 Free PMC article.
Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex®. Anne-Kristin Heninger, Sabine Wentrup, +5 authors, Jutta Schröder-Braunstein. less Immun Inflamm Dis, 2014 Dec 17; 2(3). PMID: 25505551 Free PMC article.
Current advances in T-cell-based cancer immunotherapy. Mingjun Wang, Bingnan Yin, Helen Y Wang, Rong-Fu Wang. Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524383 Free PMC article. Review.
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function. Robby Markwart, Stephanie A Condotta, +9 authors, Ignacio Rubio. less PLoS One, 2014 Dec 30; 9(12). PMID: 25541945 Free PMC article.
New insights into T-cell cosignaling in allograft rejection and survival. Scott M Krummey, Mandy L Ford. Curr Opin Organ Transplant, 2015 Jan 08; 20(1). PMID: 25563991 Free PMC article. Review.
The aptamer-siRNA conjugates: reprogramming T cells for cancer therapy. Dewan Md Sakib Hossain, Priyanka Duttagupta, Marcin Kortylewski. Ther Deliv, 2015 Jan 08; 6(1). PMID: 25565435 Free PMC article.
Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study. Daniel J Merenstein, Tina P Tan, +6 authors, Gloria Solano-Aguilar. less Gut Microbes, 2015 Jan 09; 6(1). PMID: 25569274 Free PMC article.
Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation. Karen Laky, Sharron Evans, Ainhoa Perez-Diez, B J Fowlkes. Immunity, 2015 Jan 22; 42(1). PMID: 25607460 Free PMC article.
T cell exhaustion during persistent viral infections. Shannon M Kahan, E John Wherry, Allan J Zajac. Virology, 2015 Jan 27; 479-480. PMID: 25620767 Free PMC article. Highly Cited. Review.
Novel roles of c-Met in the survival of renal cancer cells through the regulation of HO-1 and PD-L1 expression. Murugabaskar Balan, Eduardo Mier y Teran, +4 authors, Soumitro Pal. less J Biol Chem, 2015 Feb 04; 290(13). PMID: 25645920 Free PMC article.
Renal C3 complement component: feed forward to diabetic kidney disease. Katherine J Kelly, Yunlong Liu, Jizhong Zhang, Jesus H Dominguez. Am J Nephrol, 2015 Feb 11; 41(1). PMID: 25662584 Free PMC article.
TNF superfamily protein-protein interactions: feasibility of small- molecule modulation. Yun Song, Peter Buchwald. Curr Drug Targets, 2015 Feb 24; 16(4). PMID: 25706111 Free PMC article. Review.
In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation. Stéphanie O Morin, Valentin Giroux, +7 authors, Jacques A Nunès. less Cell Mol Life Sci, 2015 Mar 03; 72(14). PMID: 25725801 Free PMC article.
Immunoregulatory molecules in patients with gestational diabetes mellitus. Karen Priscilla Tezotto Pendeloski, Rosiane Mattar, +3 authors, Silvia Daher. less Endocrine, 2015 Mar 11; 50(1). PMID: 25754913
ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection. Clare L Marriott, Gianluca Carlesso, Ronald Herbst, David R Withers. Eur J Immunol, 2015 Mar 11; 45(6). PMID: 25754933 Free PMC article.
OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal. Stefanie N Linch, Michael J McNamara, William L Redmond. Front Oncol, 2015 Mar 13; 5. PMID: 25763356 Free PMC article. Highly Cited. Review.
Characterization of PD-L1 Expression and Associated T-cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites. Harriet M Kluger, Christopher R Zito, +6 authors, Lucia B Jilaveanu. less Clin Cancer Res, 2015 Mar 20; 21(13). PMID: 25788491 Free PMC article. Highly Cited.
T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance. B Ye, X Liu, +3 authors, X Li, H Kong, L Tian, Y Chen. less Cell Death Dis, 2015 Mar 20; 6. PMID: 25789969 Free PMC article. Highly Cited. Review.
TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity. Degui Geng, Sabina Kaczanowska, +5 authors, Eduardo Davila. less Cancer Res, 2015 Mar 22; 75(10). PMID: 25795705 Free PMC article.
The importance of co-stimulation in the orchestration of T helper cell differentiation. Jonathan M Coquet, Lisa Rausch, Jannie Borst. Immunol Cell Biol, 2015 Mar 25; 93(9). PMID: 25801480 Review.
New cell sources for T cell engineering and adoptive immunotherapy. Maria Themeli, Isabelle Rivière, Michel Sadelain. Cell Stem Cell, 2015 Apr 07; 16(4). PMID: 25842976 Free PMC article. Review.
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy. Mihaela Angelova, Pornpimol Charoentong, +8 authors, Zlatko Trajanoski. less Genome Biol, 2015 Apr 09; 16. PMID: 25853550 Free PMC article. Highly Cited.
Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig. Yrina Rochman, Masashi Yukawa, Andrey V Kartashov, Artem Barski. PLoS One, 2015 Apr 11; 10(4). PMID: 25860138 Free PMC article.
Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. Ewa Kozela, Ana Juknat, +3 authors, Zvi Vogel. less J Neuroinflammation, 2015 Apr 17; 12. PMID: 25880134 Free PMC article.
PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Ryan A Zander, Nyamekye Obeng-Adjei, +6 authors, Noah S Butler. less Cell Host Microbe, 2015 Apr 22; 17(5). PMID: 25891357 Free PMC article.
Boosting Cancer Immunotherapy with Anti-CD137 Antibody Therapy. Atsushi Yonezawa, Suparna Dutt, +2 authors, Cariad Chester, Jeewon Kim, Holbrook E Kohrt. less Clin Cancer Res, 2015 Apr 25; 21(14). PMID: 25908780 Free PMC article. Review.
Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens. Dallas B Flies, Tomoe Higuchi, Lieping Chen. J Immunol, 2015 Apr 29; 194(11). PMID: 25917101 Free PMC article.
NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma. Takumi Kobayashi, Brianna L Doff, +2 authors, Rory C Rearden, Graham R Leggatt, Stephen R Mattarollo. less Oncoimmunology, 2015 May 08; 4(3). PMID: 25949907 Free PMC article.
Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications. Marta E Castro-Manrreza, Juan J Montesinos. J Immunol Res, 2015 May 12; 2015. PMID: 25961059 Free PMC article. Highly Cited. Review.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. Jun Liu, Ying Yuan, +8 authors, Li Wang. less Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334 Free PMC article. Highly Cited.
Programmed death-1 controls T cell survival by regulating oxidative metabolism. Victor Tkachev, Stefanie Goodell, +5 authors, Craig A Byersdorfer. less J Immunol, 2015 May 15; 194(12). PMID: 25972478 Free PMC article.
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy. Keishi Adachi, Koji Tamada. Cancer Sci, 2015 May 20; 106(8). PMID: 25981182 Free PMC article. Review.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia. Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo. Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611 Free PMC article. Review.
Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Alice O Kamphorst, Koichi Araki, Rafi Ahmed. Vaccine, 2015 May 30; 33 Suppl 2. PMID: 26022562 Free PMC article. Review.
B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets. Liqun Luo, Gefeng Zhu, +12 authors, Lieping Chen. less PLoS One, 2015 Jun 13; 10(6). PMID: 26065426 Free PMC article.
Charting Immune Signaling Proteomes En Route to New Therapeutic Strategies. Eric B Haura, Amer A Beg, Uwe Rix, Scott Antonia. Cancer Immunol Res, 2015 Jun 18; 3(7). PMID: 26081226 Free PMC article. Review.
Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression. Danya Liu, Suzanne J Suchard, Steve G Nadler, Mandy L Ford. PLoS One, 2015 Jun 23; 10(6). PMID: 26098894 Free PMC article.
PD-L1 and Survival in Solid Tumors: A Meta-Analysis. Pin Wu, Dang Wu, +2 authors, Lijun Li, Ying Chai, Jian Huang. less PLoS One, 2015 Jun 27; 10(6). PMID: 26114883 Free PMC article. Highly Cited. Systematic Review.
The pharmacology of second-generation chimeric antigen receptors. Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain. Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802 Free PMC article. Highly Cited. Review.
Regulatory T cells and minimal change nephropathy: in the midst of a complex network. R Bertelli, A Bonanni, +3 authors, A Di Donato, M Cioni, P Ravani, G M Ghiggeri. less Clin Exp Immunol, 2015 Jul 07; 183(2). PMID: 26147676 Free PMC article. Review.
Clinical Development of Immune Checkpoint Inhibitors. Ayumu Ito, Shunsuke Kondo, Kohei Tada, Shigehisa Kitano. Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161407 Free PMC article. Review.
Inhibitory Receptors Beyond T Cell Exhaustion. Silvia A Fuertes Marraco, Natalie J Neubert, Grégory Verdeil, Daniel E Speiser. Front Immunol, 2015 Jul 15; 6. PMID: 26167163 Free PMC article. Highly Cited. Review.
Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation. Bala Sai Sundarasetty, Stephan Kloess, +14 authors, Renata Stripecke. less J Transl Med, 2015 Jul 23; 13. PMID: 26198406 Free PMC article.
HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications. Zaruhi Karabekian, Hao Ding, +9 authors, Narine Sarvazyan. less Tissue Eng Part A, 2015 Jul 29; 21(19-20). PMID: 26218149 Free PMC article.
Combination cancer immunotherapy and new immunomodulatory targets. Kathleen M Mahoney, Paul D Rennert, Gordon J Freeman. Nat Rev Drug Discov, 2015 Aug 01; 14(8). PMID: 26228759 Highly Cited. Review.
Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism. C Krupka, P Kufer, +14 authors, M Subklewe. less Leukemia, 2015 Aug 05; 30(2). PMID: 26239198 Highly Cited.
IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice. Rafael R Flores, Eun Kim, +4 authors, Paul D Robbins. less Eur J Immunol, 2015 Aug 12; 45(11). PMID: 26260044 Free PMC article.
1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept. David H Gardner, Louisa E Jeffery, +4 authors, David M Sansom. less J Immunol, 2015 Aug 16; 195(6). PMID: 26276872 Free PMC article.
The Role of PKC-θ in CD4+ T Cells and HIV Infection: To the Nucleus and Back Again. Chansavath Phetsouphanh, Anthony D Kelleher. Front Immunol, 2015 Aug 19; 6. PMID: 26284074 Free PMC article. Review.
T-cell ligands modulate the cytolytic activity of the CD33/CD3 BiTE antibody construct, AMG 330. G S Laszlo, C J Gudgeon, K H Harrington, R B Walter. Blood Cancer J, 2015 Aug 22; 5. PMID: 26295610 Free PMC article.
Perspectives in the treatment of pancreatic adenocarcinoma. Angel Cid-Arregui, Victoria Juarez. World J Gastroenterol, 2015 Aug 27; 21(31). PMID: 26309356 Free PMC article. Review.
Novel Immune Check-Point Regulators in Tolerance Maintenance. Yanxia Guo, Adele Y Wang. Front Immunol, 2015 Sep 09; 6. PMID: 26347744 Free PMC article. Review.
CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection. R A Drummond, I M Dambuza, +7 authors, G D Brown. less Mucosal Immunol, 2015 Sep 10; 9(2). PMID: 26349660 Free PMC article.
Transient Loss of Protection Afforded by a Live Attenuated Non-typhoidal Salmonella Vaccine in Mice Co-infected with Malaria. Jason P Mooney, Seung-Joo Lee, +4 authors, Renée M Tsolis. less PLoS Negl Trop Dis, 2015 Sep 15; 9(9). PMID: 26366739 Free PMC article.
Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysis. Tengfei Zhang, Ling Cao, +10 authors, Yi Zhang. less Oncotarget, 2015 Sep 18; 6(32). PMID: 26376680 Free PMC article.
Clinical significance of tumor-infiltrating immune cells focusing on BTLA and Cbl-b in patients with gallbladder cancer. Seiji Oguro, Yoshinori Ino, +7 authors, Nobuyoshi Hiraoka. less Cancer Sci, 2015 Sep 24; 106(12). PMID: 26395180 Free PMC article.
Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody. L Xue, T Hickling, +2 authors, R Song, J Nowak, B Rup. less Clin Exp Immunol, 2015 Sep 25; 183(1). PMID: 26400440 Free PMC article.
Nivolumab in combination with ipilimumab for the treatment of melanoma. Rajasekharan Somasundaram, Meenhard Herlyn. Expert Rev Anticancer Ther, 2015 Sep 25; 15(10). PMID: 26402246 Free PMC article. Review.
A three-signal model of T-cell lymphoma pathogenesis. Ryan A Wilcox. Am J Hematol, 2015 Sep 27; 91(1). PMID: 26408334 Free PMC article. Review.
Biomarkers for Sepsis: What Is and What Might Be? Bethany M Biron, Alfred Ayala, Joanne L Lomas-Neira. Biomark Insights, 2015 Sep 30; 10(Suppl 4). PMID: 26417200 Free PMC article. Review.
Potentiality of immunotherapy against hepatocellular carcinoma. Nobuhiro Tsuchiya, Yu Sawada, +2 authors, Itaru Endo, Yasushi Uemura, Tetsuya Nakatsura. less World J Gastroenterol, 2015 Oct 01; 21(36). PMID: 26420958 Free PMC article. Review.
Integrated molecular analysis of adult T cell leukemia/lymphoma. Keisuke Kataoka, Yasunobu Nagata, +56 authors, Seishi Ogawa. less Nat Genet, 2015 Oct 06; 47(11). PMID: 26437031 Highly Cited.
Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells. Dongmei Fan, Wei Li, +6 authors, Dongsheng Xiong. less J Hematol Oncol, 2015 Oct 09; 8. PMID: 26444983 Free PMC article.
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells. Zeguo Zhao, Maud Condomines, +5 authors, Michel Sadelain. less Cancer Cell, 2015 Oct 16; 28(4). PMID: 26461090 Free PMC article. Highly Cited.
Comparing the Primary and Recall Immune Response Induced by a New EV71 Vaccine Using Systems Biology Approaches. Jie Shao, Junnan Zhang, +7 authors, Junzhi Wang. less PLoS One, 2015 Oct 16; 10(10). PMID: 26465882 Free PMC article.
High intensity focused ultrasound enhances anti-tumor immunity by inhibiting the negative regulatory effect of miR-134 on CD86 in a murine melanoma model. Shi-Mei Yuan, Huan Li, +12 authors, Lan Zhou. less Oncotarget, 2015 Oct 21; 6(35). PMID: 26485753 Free PMC article.
Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab. Venky Ramakrishna, Karuna Sundarapandiyan, +3 authors, Tibor Keler. less J Immunother Cancer, 2015 Oct 27; 3. PMID: 26500773 Free PMC article.
Current Treatment, Emerging Translational Therapies, and New Therapeutic Targets for Autoimmune Myasthenia Gravis. Jeffrey T Guptill, Madhu Soni, Matthew N Meriggioli. Neurotherapeutics, 2015 Oct 30; 13(1). PMID: 26510558 Free PMC article. Review.
The role of lymphocytes in the development and treatment of alopecia areata. Hongwei Guo, Yabin Cheng, Jerry Shapiro, Kevin McElwee. Expert Rev Clin Immunol, 2015 Nov 10; 11(12). PMID: 26548356 Free PMC article. Review.
Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer. Joseph McLaughlin, Gang Han, +7 authors, David L Rimm. less JAMA Oncol, 2015 Nov 13; 2(1). PMID: 26562159 Free PMC article. Highly Cited.
Temporal protein expression pattern in intracellular signalling cascade during T-cell activation: a computational study. Piyali Ganguli, Saikat Chowdhury, Rupa Bhowmick, Ram Rup Sarkar. J Biosci, 2015 Nov 14; 40(4). PMID: 26564978
Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy. Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong. J Immunol Res, 2015 Nov 19; 2015. PMID: 26579545 Free PMC article. Review.
FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression. Anil K Chauhan, Terry L Moore, Ye Bi, Chen Chen. J Biol Chem, 2015 Nov 20; 291(3). PMID: 26582197 Free PMC article.
Are Microglial Cells the Regulators of Lymphocyte Responses in the CNS? Beatriz Almolda, Berta González, Bernardo Castellano. Front Cell Neurosci, 2015 Dec 05; 9. PMID: 26635525 Free PMC article. Review.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy. Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake. Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632 Free PMC article. Review.
Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. R D Fannin, K Gerrish, +3 authors, S O Sieber, P R Bushel, P B Watkins, R S Paules. less Clin Pharmacol Ther, 2015 Dec 23; 99(4). PMID: 26690555 Free PMC article.
Sepsis-induced immune dysfunction: can immune therapies reduce mortality? Matthew J Delano, Peter A Ward. J Clin Invest, 2016 Jan 05; 126(1). PMID: 26727230 Free PMC article. Highly Cited. Review.
HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). Keiko Yasuma, Jun-ichirou Yasunaga, +6 authors, Masao Matsuoka. less PLoS Pathog, 2016 Jan 07; 12(1). PMID: 26735971 Free PMC article.
Identification of CD112R as a novel checkpoint for human T cells. Yuwen Zhu, Alessandro Paniccia, +6 authors, Barish H Edil. less J Exp Med, 2016 Jan 13; 213(2). PMID: 26755705 Free PMC article.
Roles of PD-1, Tim-3 and CTLA-4 in immunoregulation in regulatory T cells among patients with sepsis. Dong-Na Gao, Zhi-Xiang Yang, Qing-Hui Qi. Int J Clin Exp Med, 2016 Jan 16; 8(10). PMID: 26770525 Free PMC article.
Immunotherapy: New Strategies for the Treatment of Gynecologic Malignancies. Ariel Bulua Bourla, Dmitriy Zamarin. Oncology (Williston Park), 2016 Jan 23; 30(1). PMID: 26791846 Free PMC article. Review.
Impact of host genetic polymorphisms on vaccine induced antibody response. Janina E Linnik, Adrian Egli. Hum Vaccin Immunother, 2016 Jan 27; 12(4). PMID: 26809773 Free PMC article. Review.
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Kole T Roybal, Levi J Rupp, +4 authors, Wendell A Lim. less Cell, 2016 Feb 03; 164(4). PMID: 26830879 Free PMC article. Highly Cited.
Generating Peripheral Blood Derived Lymphocytes Reacting Against Autologous Primary AML Blasts. Rohtesh S Mehta, Xiaohua Chen, +2 authors, Jeyaraj Antony, Michael Boyiadzis, Paul Szabolcs. less J Immunother, 2016 Feb 06; 39(2). PMID: 26849076 Free PMC article.
Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction. Anna Lissina, David R Ambrozak, +12 authors, Victor Appay. less Immunol Cell Biol, 2016 Feb 11; 94(6). PMID: 26860368
Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma. Dai Liu, Kevin F Staveley-O'Carroll, Guangfu Li. J Clin Cell Immunol, 2016 Feb 16; 6(6). PMID: 26877890 Free PMC article.
Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse. Claire Hivroz, Michael Saitakis. Front Immunol, 2016 Feb 26; 7. PMID: 26913033 Free PMC article. Review.
Memory T cells in organ transplantation: progress and challenges. Jaclyn R Espinosa, Kannan P Samy, Allan D Kirk. Nat Rev Nephrol, 2016 Mar 01; 12(6). PMID: 26923209 Free PMC article. Review.
Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities. K M Morrissey, T M Yuraszeck, +2 authors, C-C Li, Y Zhang, S Kasichayanula. less Clin Transl Sci, 2016 Mar 01; 9(2). PMID: 26924066 Free PMC article. Highly Cited. Review.
Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism. Sara Labiano, Asis Palazón, +11 authors, Ignacio Melero. less Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942078 Free PMC article.
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging. Liang Han, Derek K Kong, +16 authors, Jiangbing Zhou. less ACS Nano, 2016 Mar 12; 10(4). PMID: 26967254 Free PMC article.
T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells. James M Conley, Michael P Gallagher, Leslie J Berg. Front Immunol, 2016 Mar 15; 7. PMID: 26973653 Free PMC article. Review.
Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse. William A Comrie, Janis K Burkhardt. Front Immunol, 2016 Mar 26; 7. PMID: 27014258 Free PMC article. Review.
Leveraging immunotherapy for the treatment of gynecologic cancers in the era of precision medicine. Dmitriy Zamarin, Amir A Jazaeri. Gynecol Oncol, 2016 Mar 27; 141(1). PMID: 27016233 Free PMC article. Review.
Molecular alterations in the TCR signaling pathway in patients with aplastic anemia. Bo Li, Lixing Guo, +7 authors, Yangqiu Li. less J Hematol Oncol, 2016 Apr 03; 9. PMID: 27036622 Free PMC article.
Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study. Eric D Donnenfeld, Paul M Karpecki, +4 authors, Charles P Semba. less Cornea, 2016 Apr 08; 35(6). PMID: 27055211 Free PMC article.
Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function. Soumaya Kouidhi, Muhammad Zaeem Noman, +2 authors, Salem Chouaib. less Front Immunol, 2016 Apr 12; 7. PMID: 27066006 Free PMC article. Review.
Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus. B A Sullivan, W Tsuji, +9 authors, J B Chung. less Lupus Sci Med, 2016 Apr 22; 3(1). PMID: 27099766 Free PMC article.
Potentiation of immunomodulatory antibody therapy with oncolytic viruses for treatment of cancer. Dmitriy Zamarin, Jedd D Wolchok. Mol Ther Oncolytics, 2014 Jan 01; 1. PMID: 27119094 Free PMC article. Review.
Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools. Jared Klarquist, Zhenyuan Zhou, Nan Shen, Edith M Janssen. Mediators Inflamm, 2016 Apr 29; 2016. PMID: 27122656 Free PMC article. Review.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Itay Tirosh, Benjamin Izar, +34 authors, Levi A Garraway. less Science, 2016 Apr 29; 352(6282). PMID: 27124452 Free PMC article. Highly Cited.
Pembrolizumab in classical Hodgkin's lymphoma. Joseph Maly, Lapo Alinari. Eur J Haematol, 2016 May 06; 97(3). PMID: 27147112 Free PMC article. Review.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas. Daniel E Lowther, Brittany A Goods, +10 authors, David A Hafler. less JCI Insight, 2016 May 18; 1(5). PMID: 27182555 Free PMC article. Highly Cited.
Expression of PD-1 on CD4+ T cells in peripheral blood associates with poor clinical outcome in non-small cell lung cancer. Hong Zheng, Xin Liu, +7 authors, Chandra P Belani. less Oncotarget, 2016 May 19; 7(35). PMID: 27191652 Free PMC article.
Programmed death-ligand-1 expression in advanced gastric cancer detected with RNA in situ hybridization and its clinical significance. Jiajia Yuan, Jie Zhang, +8 authors, Lin Shen. less Oncotarget, 2016 Oct 26; 7(26). PMID: 27191996 Free PMC article.
CD28 Costimulation: From Mechanism to Therapy. Jonathan H Esensten, Ynes A Helou, +2 authors, Gaurav Chopra, Arthur Weiss, Jeffrey A Bluestone. less Immunity, 2016 May 19; 44(5). PMID: 27192564 Free PMC article. Highly Cited. Review.
Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation-Novel Paradigm and Therapeutic Potential. Xin Wang, Ya-Feng Li, +9 authors, Xiao-Feng Yang. less J Cardiovasc Transl Res, 2016 May 28; 9(4). PMID: 27230673 Free PMC article.
Checkpoint Inhibitors and Their Application in Breast Cancer. Davide Bedognetti, Cristina Maccalli, +2 authors, Barbara Seliger. less Breast Care (Basel), 2016 May 31; 11(2). PMID: 27239172 Free PMC article. Review.
Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. Ewa Kozela, Ana Juknat, +3 authors, Zvi Vogel. less J Neuroinflammation, 2016 Jun 04; 13(1). PMID: 27256343 Free PMC article.
Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway. Rong Wang, Aizhang Xu, +4 authors, Jim Xiang. less Cell Mol Immunol, 2016 Jun 07; 14(6). PMID: 27264687 Free PMC article.
A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. Benjamin Goetz, Wei An, +7 authors, Hamid Band. less Oncotarget, 2016 Jun 09; 7(32). PMID: 27276677 Free PMC article.
Effector, Memory, and Dysfunctional CD8(+) T Cell Fates in the Antitumor Immune Response. John Reiser, Arnob Banerjee. J Immunol Res, 2016 Jun 18; 2016. PMID: 27314056 Free PMC article. Review.
CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade. Zong-Sheng Tang, You-Hua Hao, +4 authors, Dong-Liang Yang. less Mol Med Rep, 2016 Jun 18; 14(2). PMID: 27314219 Free PMC article.
Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein Interaction. Rushikesh Sable, Thomas Durek, +4 authors, Seetharama Jois. less ACS Chem Biol, 2016 Jun 24; 11(8). PMID: 27337048 Free PMC article.
A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood. Jennifer M Dan, Cecilia S Lindestam Arlehamn, +7 authors, Shane Crotty. less J Immunol, 2016 Jun 28; 197(3). PMID: 27342848 Free PMC article. Highly Cited.
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Junjie Zhang, Hao Feng, +7 authors, Pinghui Feng. less Cell Rep, 2016 Jun 28; 16(2). PMID: 27346349 Free PMC article.
Differential Expression of Immune Checkpoint Modulators on In Vitro Primed CD4(+) and CD8(+) T Cells. Nina C Sabins, Benjamin C Harman, +2 authors, Linda R Barone, Shixue Shen, Sandra Santulli-Marotto. less Front Immunol, 2016 Jul 06; 7. PMID: 27379090 Free PMC article.
Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups. Dvir Netanely, Ayelet Avraham, +2 authors, Adit Ben-Baruch, Ella Evron, Ron Shamir. less Breast Cancer Res, 2016 Jul 09; 18(1). PMID: 27386846 Free PMC article.
Role of cellular events in the pathophysiology of sepsis. Chandra Bhan, Pankaj Dipankar, Papiya Chakraborty, Pranita P Sarangi. Inflamm Res, 2016 Jul 10; 65(11). PMID: 27392441 Review.
CD28 days later: Resurrecting costimulation for CD8(+) memory T cells. Verena van der Heide, Dirk Homann. Eur J Immunol, 2016 Jul 13; 46(7). PMID: 27401871 Free PMC article.
T Cells Going Innate. Midas Seyda, Abdallah Elkhal, +2 authors, Markus Quante, Christine S Falk, Stefan G Tullius. less Trends Immunol, 2016 Jul 13; 37(8). PMID: 27402226 Free PMC article. Review.
Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. Matthias Hoffmann, Nikos Pantazis, +16 authors, SPARTAC and CHERUB Investigators. less PLoS Pathog, 2016 Jul 16; 12(7). PMID: 27415828 Free PMC article. Highly Cited.
CD137-CRDI is not necessary in the role of contacting its natural ligand. Ling Yi, Zhuohong Yan, +3 authors, Hongtao Zhang. less Immunol Cell Biol, 2016 Jul 20; 95(1). PMID: 27430526
Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300. Yun-Ji Jeung, Han-Gyeul Kim, +9 authors, Kyung-Sook Chung. less Biochim Biophys Acta, 2016 Jul 28; 1863(11). PMID: 27452907
Flt3 Ligand Treatment Attenuates T Cell Dysfunction and Improves Survival in a Murine Model of Burn Wound Sepsis. Naeem K Patil, Julia K Bohannon, +5 authors, Edward R Sherwood. less Shock, 2016 Jul 28; 47(1). PMID: 27454384 Free PMC article.
T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions. Zeynep Sener, Fritjof H Cederkvist, +2 authors, Roman Volchenkov, Halvor L Holen, Bjørn S Skålhegg. less PLoS One, 2016 Jul 29; 11(7). PMID: 27467144 Free PMC article.
Contemporary Treatment of Metastatic Renal Cell Carcinoma. Igor Stukalin, Nimira Alimohamed, Daniel Y C Heng. Oncol Rev, 2016 Jul 30; 10(1). PMID: 27471582 Free PMC article. Review.
Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy. Aitziber Buqué, Norma Bloy, +10 authors, Lorenzo Galluzzi. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471617 Free PMC article. Review.
CD28 co-stimulation in T-cell homeostasis: a recent perspective. Niklas Beyersdorf, Thomas Kerkau, Thomas Hünig. Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471717 Free PMC article. Review.
Costimulation Blockade in Kidney Transplantation: An Update. Paolo Malvezzi, Thomas Jouve, Lionel Rostaing. Transplantation, 2016 Oct 25; 100(11). PMID: 27472094 Free PMC article. Review.
Enhanced Requirement for TNFR2 in Graft Rejection Mediated by Low-Affinity Memory CD8+ T Cells during Heterologous Immunity. Scott M Krummey, Ching-Wen Chen, +4 authors, Mandy L Ford. less J Immunol, 2016 Aug 03; 197(5). PMID: 27481849 Free PMC article.
Immune checkpoints and the HIV-1 reservoir: proceed with caution. Rikke Olesen, Steffen Leth, +4 authors, Martin Tolstrup. less J Virus Erad, 2016 Aug 03; 2(3). PMID: 27482460 Free PMC article.
Ubc13: the Lys63 ubiquitin chain building machine. Curtis D Hodge, Leo Spyracopoulos, J N Mark Glover. Oncotarget, 2016 Aug 04; 7(39). PMID: 27486774 Free PMC article. Review.
Classification of Advanced Human Cancers Based on Tumor Immunity in the MicroEnvironment (TIME) for Cancer Immunotherapy. Yu Zhang, Lieping Chen. JAMA Oncol, 2016 Aug 05; 2(11). PMID: 27490017 Free PMC article.
Antigen Presentation After Stroke. Francesc Miró-Mur, Xabier Urra, +2 authors, Mattia Gallizioli, Angel Chamorro, Anna M Planas. less Neurotherapeutics, 2016 Oct 21; 13(4). PMID: 27514673 Free PMC article. Review.
Emerging infection and sepsis biomarkers: will they change current therapies? Lauren Jacobs, Hector R Wong. Expert Rev Anti Infect Ther, 2016 Aug 18; 14(10). PMID: 27533847 Free PMC article. Review.
Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation. Lindsay J Celada, Joseph E Rotsinger, +4 authors, Wonder P Drake. less Am J Respir Cell Mol Biol, 2016 Aug 27; 56(1). PMID: 27564547 Free PMC article.
Complementing T-cell Function: An Inhibitory Role of the Complement System in T-cell-Mediated Antitumor Immunity. Weiyi Peng, Jodi A McKenzie, Patrick Hwu. Cancer Discov, 2016 Sep 03; 6(9). PMID: 27587467 Free PMC article.
Specific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis. Elia Moreno-Cubero, Juan-Ramón Larrubia. World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605882 Free PMC article. Review.
An alternative mode of CD43 signal transduction activates pro-survival pathways of T lymphocytes. Maria Elena Bravo-Adame, Rosario Vera-Estrella, +5 authors, Yvonne Rosenstein. less Immunology, 2016 Sep 09; 150(1). PMID: 27606486 Free PMC article.
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology. Mark J Selby, John J Engelhardt, +11 authors, Alan J Korman. less PLoS One, 2016 Sep 10; 11(9). PMID: 27610613 Free PMC article. Highly Cited.
Risk stratification and immunogenetic risk for infections following stem cell transplantation. Agnieszka Wójtowicz, Pierre-Yves Bochud. Virulence, 2016 Sep 11; 7(8). PMID: 27612400 Free PMC article. Review.
Forsythoside A Inhibits BVDV Replication via TRAF2-Dependent CD28-4-1BB Signaling in Bovine PBMCs. Quan-Jiang Song, Xiao-Gang Weng, +2 authors, Dong-Jie Cai, Wang Zhang, Jiu-Feng Wang. less PLoS One, 2016 Sep 13; 11(9). PMID: 27617959 Free PMC article.
OMIP-036: Co-inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets. Zachary R Healy, David M Murdoch. Cytometry A, 2016 Oct 22; 89(10). PMID: 27623134 Free PMC article.
TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis. Xinru Zhou, Yong Mao, +12 authors, Xueguang Zhang. less Oncotarget, 2016 Sep 15; 7(41). PMID: 27626488 Free PMC article.
Prevention of allograft rejection in heart transplantation through concurrent gene silencing of TLR and Kinase signaling pathways. Hongmei Wang, Xusheng Zhang, +8 authors, Weiping Min. less Sci Rep, 2016 Sep 24; 6. PMID: 27659428 Free PMC article.
Tr1-Like T Cells - An Enigmatic Regulatory T Cell Lineage. Anna Malgorzata White, David C Wraith. Front Immunol, 2016 Sep 30; 7. PMID: 27683580 Free PMC article.
T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts. Judith Feucht, Simone Kayser, +10 authors, Tobias Feuchtinger. less Oncotarget, 2016 Oct 07; 7(47). PMID: 27708227 Free PMC article.
A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte predominant Hodgkin lymphoma. Bianca Schuhmacher, Benjamin Rengstl, +8 authors, Sylvia Hartmann. less Oncotarget, 2016 Oct 07; 7(44). PMID: 27708232 Free PMC article.
Malignant inflammation in cutaneous T-cell lymphoma-a hostile takeover. Thorbjørn Krejsgaard, Lise M Lindahl, +6 authors, Niels Odum. less Semin Immunopathol, 2016 Oct 09; 39(3). PMID: 27717961 Free PMC article. Review.
Recombinant human lactoferrin modulates human PBMC derived macrophage responses to BCG and LPS. Shen-An Hwang, Marian L Kruzel, Jeffrey K Actor. Tuberculosis (Edinb), 2016 Oct 12; 101S. PMID: 27727130 Free PMC article.
The immune system's role in sepsis progression, resolution, and long-term outcome. Matthew J Delano, Peter A Ward. Immunol Rev, 2016 Oct 27; 274(1). PMID: 27782333 Free PMC article. Highly Cited. Review.
Co-stimulation Blockade Plus T-Cell Depletion in Transplant Patients: Towards a Steroid- and Calcineurin Inhibitor-Free Future? Florence Herr, Melanie Brunel, Nathalie Roders, Antoine Durrbach. Drugs, 2016 Oct 28; 76(17). PMID: 27785759 Review.
Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy. Ju Yeon Lee, Hyun Tae Lee, +11 authors, Yong-Seok Heo. less Nat Commun, 2016 Nov 01; 7. PMID: 27796306 Free PMC article. Highly Cited.
Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation. Jeffrey J Teoh, Awndre E Gamache, +4 authors, Michael G Brown. less J Immunol, 2016 Nov 01; 197(11). PMID: 27798162 Free PMC article.
PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Aaron Goodman, Sandip P Patel, Razelle Kurzrock. Nat Rev Clin Oncol, 2016 Nov 03; 14(4). PMID: 27805626 Highly Cited. Review.
Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization. Lei Dong, Alexandra Helmke, +3 authors, Sibylle von Vietinghoff. less Sci Rep, 2016 Nov 04; 6. PMID: 27808281 Free PMC article.
Unraveling the Role of Allo-Antibodies and Transplant Injury. Yoshiko Matsuda, Minnie M Sarwal. Front Immunol, 2016 Nov 08; 7. PMID: 27818660 Free PMC article. Review.
LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells. Sook-Kyoung Heo, Eui-Kyu Noh, +7 authors, Hawk Kim. less PLoS One, 2016 Nov 12; 11(11). PMID: 27835685 Free PMC article.
Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody. Di Zhang, Monica V Goldberg, Mark L Chiu. J Biol Chem, 2016 Nov 20; 291(53). PMID: 27856634 Free PMC article.
The CD8 T-cell response during tolerance induction in liver transplantation. Yik Chun Wong, Geoffrey W McCaughan, David G Bowen, Patrick Bertolino. Clin Transl Immunology, 2016 Nov 22; 5(10). PMID: 27867515 Free PMC article. Review.
Autoantibodies against CD80 in patients with COPD. Xu Min Luo, Xin Yan Liu, +4 authors, Xiongbiao Wang. less Clin Transl Immunology, 2016 Nov 22; 5(10). PMID: 27867516 Free PMC article.
T-cell stimuli independently sum to regulate an inherited clonal division fate. J M Marchingo, G Prevedello, +3 authors, A Kan, S Heinzel, P D Hodgkin, K R Duffy. less Nat Commun, 2016 Nov 22; 7. PMID: 27869196 Free PMC article.
T regulatory cell mediated immunotherapy for solid organ transplantation: A clinical perspective. Mohammad Afzal Khan. Mol Med, 2016 Nov 24; 22. PMID: 27878210 Free PMC article.
The emerging role of immune checkpoint inhibition in malignant lymphoma. Ida Hude, Stephanie Sasse, Andreas Engert, Paul J Bröckelmann. Haematologica, 2016 Nov 26; 102(1). PMID: 27884973 Free PMC article. Review.
Transplantation tolerance after allograft rejection. Michelle L Miller, Maria-Luisa Alegre, Anita S Chong. Curr Opin Organ Transplant, 2016 Nov 30; 22(1). PMID: 27898463 Free PMC article. Review.
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression. Limo Chen, Xiaohui Yi, +13 authors, Don L Gibbons. less Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999749 Free PMC article.
Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format. Sina Fellermeier, Nadine Beha, +4 authors, Dafne Müller. less Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999756 Free PMC article.
Immune targets and neoantigens for cancer immunotherapy and precision medicine. Rong-Fu Wang, Helen Y Wang. Cell Res, 2016 Dec 28; 27(1). PMID: 28025978 Free PMC article. Highly Cited. Review.
Update on immune checkpoint inhibitors in gynecological cancers. Valerie Heong, Natalie Ngoi, David Shao Peng Tan. J Gynecol Oncol, 2016 Dec 29; 28(2). PMID: 28028993 Free PMC article. Review.
Unusual CD4+CD28- T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders. Ga Hye Lee, Won-Woo Lee. Immune Netw, 2016 Dec 31; 16(6). PMID: 28035207 Free PMC article. Review.
Death receptor 6 contributes to autoimmunity in lupus-prone mice. Daisuke Fujikura, Masahiro Ikesue, +3 authors, Toshimitsu Uede. less Nat Commun, 2017 Jan 04; 8. PMID: 28045014 Free PMC article.
HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. Haruka Kinosada, Jun-Ichirou Yasunaga, +5 authors, Masao Matsuoka. less PLoS Pathog, 2017 Jan 04; 13(1). PMID: 28046066 Free PMC article.
Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung. A C Zhou, L E Wagar, M E Wortzman, T H Watts. Mucosal Immunol, 2017 Jan 05; 10(5). PMID: 28051085
Immunoplasticity in cutaneous melanoma: beyond pure morphology. Francesca Maria Bosisio, Joost J van den Oord. Virchows Arch, 2017 Jan 06; 470(4). PMID: 28054151 Review.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy. Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger. Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373 Free PMC article. Highly Cited. Review.
Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases. Hyung Jun Woo, Chenggang Yu, Jaques Reifman. PLoS One, 2017 Jan 13; 12(1). PMID: 28081217 Free PMC article.
CD24: A Rheostat That Modulates Cell Surface Receptor Signaling of Diverse Receptors. D Craig Ayre, Sherri L Christian. Front Cell Dev Biol, 2017 Jan 14; 4. PMID: 28083532 Free PMC article.
T-cell receptor-engineered T cells for cancer treatment: current status and future directions. Yu Ping, Chaojun Liu, Yi Zhang. Protein Cell, 2017 Jan 22; 9(3). PMID: 28108950 Free PMC article. Highly Cited. Review.
A human immunodeficiency syndrome caused by mutations in CARMIL2. T Schober, T Magg, +17 authors, F Hauck. less Nat Commun, 2017 Jan 24; 8. PMID: 28112205 Free PMC article.
New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone. Siwen Hu-Lieskovan, Antoni Ribas. Cancer J, 2017 Jan 24; 23(1). PMID: 28114250 Free PMC article. Review.
Therapeutic effect of human ghrelin and growth hormone: Attenuation of immunosuppression in septic aged rats. Mian Zhou, Weng-Lang Yang, +2 authors, Monowar Aziz, Gaifeng Ma, Ping Wang. less Biochim Biophys Acta Mol Basis Dis, 2017 Jan 25; 1863(10 Pt B). PMID: 28115288 Free PMC article.
PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective. Jun Wang, Ruirong Yuan, +3 authors, Wenru Song, Jingwei Sun, Delong Liu, Zihai Li. less J Hematol Oncol, 2017 Jan 27; 10(1). PMID: 28122590 Free PMC article. Highly Cited. Review.
Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity. Xiao Hu, Xikui Liu, +19 authors, Laura L Carter. less Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123897 Free PMC article.
Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis. Elma Kadić, Raymond J Moniz, +2 authors, Ying Huo, An Chi, Ilona Kariv. less BMC Immunol, 2017 Feb 06; 18(1). PMID: 28148223 Free PMC article.
Tumor regulation of the tissue environment in the liver. Tobias Eggert, Tim F Greten. Pharmacol Ther, 2017 Feb 09; 173. PMID: 28167218 Free PMC article. Review.
Attenuation of lymphocyte immune responses during Mycobacterium avium complex-induced lung disease due to increasing expression of programmed death-1 on lymphocytes. Chin-Chung Shu, Jann-Yuan Wang, +5 authors, Chong-Jen Yu. less Sci Rep, 2017 Feb 09; 7. PMID: 28169347 Free PMC article.
CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Anna Brewitz, Sarah Eickhoff, +13 authors, Wolfgang Kastenmüller. less Immunity, 2017 Feb 14; 46(2). PMID: 28190711 Free PMC article. Highly Cited.
Inappropriate costimulation and aberrant DNA methylation as therapeutic targets in angioimmunoblastic T-cell lymphoma. Mathijs Willemsen, Harry C Schouten. Biomark Res, 2017 Feb 15; 5. PMID: 28194275 Free PMC article.
Macrophage regulation of B cell proliferation. Naomi Goldman, Kornelija Valiuskyte, +3 authors, James E Riggs. less Cell Immunol, 2017 Feb 28; 314. PMID: 28238361 Free PMC article.
Interplay between Immune Checkpoint Proteins and Cellular Metabolism. Sangbin Lim, Joshua B Phillips, +4 authors, Ming Tan. less Cancer Res, 2017 Mar 02; 77(6). PMID: 28246276 Free PMC article. Review.
The Unique Molecular and Cellular Microenvironment of Ovarian Cancer. Thomas Worzfeld, Elke Pogge von Strandmann, +4 authors, Rolf Müller. less Front Oncol, 2017 Mar 10; 7. PMID: 28275576 Free PMC article. Highly Cited. Review.
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Enfu Hui, Jeanne Cheung, +8 authors, Ronald D Vale. less Science, 2017 Mar 11; 355(6332). PMID: 28280247 Free PMC article. Highly Cited.
Old game, new players: Linking classical theories to new trends in transplant immunology. Marina Burgos da Silva, Flavia Franco da Cunha, Fernanda Fernandes Terra, Niels Olsen Saraiva Camara. World J Transplant, 2017 Mar 11; 7(1). PMID: 28280691 Free PMC article. Review.
Immunotherapy in pancreatic cancer treatment: a new frontier. Komal Thind, Leslie J Padrnos, Ramesh K Ramanathan, Mitesh J Borad. Therap Adv Gastroenterol, 2017 Mar 14; 10(1). PMID: 28286568 Free PMC article. Review.
Dying cells actively regulate adaptive immune responses. Nader Yatim, Sean Cullen, Matthew L Albert. Nat Rev Immunol, 2017 Mar 14; 17(4). PMID: 28287107 Highly Cited. Review.
The Microenvironmental Landscape of Brain Tumors. Daniela F Quail, Johanna A Joyce. Cancer Cell, 2017 Mar 16; 31(3). PMID: 28292436 Free PMC article. Highly Cited. Review.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma. Manohan Sinnadurai, Kerrie L McDonald. J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764 Review.
Interleukin-4 Inhibits Regulatory T Cell Differentiation through Regulating CD103+ Dendritic Cells. Lei Tu, Jie Chen, Hongwei Zhang, Lihua Duan. Front Immunol, 2017 Mar 21; 8. PMID: 28316599 Free PMC article.
Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines. Jason Lohmueller, Olivera J Finn. Pharmacol Ther, 2017 Mar 23; 178. PMID: 28322974 Free PMC article. Review.
Development of CAR T cells designed to improve antitumor efficacy and safety. Janneke E Jaspers, Renier J Brentjens. Pharmacol Ther, 2017 Mar 28; 178. PMID: 28342824 Free PMC article. Review.
Impact of Metabolism on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment. Soumaya Kouidhi, Amel Benammar Elgaaied, Salem Chouaib. Front Immunol, 2017 Mar 30; 8. PMID: 28348562 Free PMC article. Review.
STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer. Rui Li, Fang Fang, +13 authors, Weihua Xiao. less Sci Rep, 2017 Mar 30; 7. PMID: 28350008 Free PMC article.
HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice. Rashida Ginwala, Breanna Caruso, +8 authors, Pooja Jain. less J Neuroimmune Pharmacol, 2017 Apr 05; 12(3). PMID: 28374110 Free PMC article.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors. Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri. less Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974 Free PMC article. Review.
In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance. Ryan M Pearson, Liam M Casey, +2 authors, Kevin R Hughes, Stephen D Miller, Lonnie D Shea. less Adv Drug Deliv Rev, 2017 Apr 18; 114. PMID: 28414079 Free PMC article. Review.
PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells. Xiong Ni, Qingxiao Song, +9 authors, Defu Zeng. less J Clin Invest, 2017 Apr 18; 127(5). PMID: 28414296 Free PMC article.
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel. Melita Irving, Romain Vuillefroy de Silly, +2 authors, Kirsten Scholten, Nahzli Dilek, George Coukos. less Front Immunol, 2017 Apr 20; 8. PMID: 28421069 Free PMC article. Review.
Phenotypic characterization and anticancer capacity of CD8+ cytokine-induced killer cells after antigen-induced expansion. Jianhua Liu, Lu Wang, +2 authors, Yaoling Wang, Wenjie Zhang, Yilin Cao. less PLoS One, 2017 Apr 21; 12(4). PMID: 28426690 Free PMC article.
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Kole T Roybal, Wendell A Lim. Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446063 Free PMC article. Review.
Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy. Seema Gupta, Amrita Roy, Bilikere S Dwarakanath. Front Oncol, 2017 Apr 28; 7. PMID: 28447025 Free PMC article. Highly Cited. Review.
Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis. Na Li, Wenwen Xu, +11 authors, Li Wang. less Sci Rep, 2017 May 05; 7(1). PMID: 28469254 Free PMC article.
B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb. Xinxin Nie, Wenni Chen, +8 authors, Lieping Chen. less Cell Mol Immunol, 2017 May 10; 15(10). PMID: 28479601 Free PMC article.
Checkpoint inhibitors in hematological malignancies. Chi Young Ok, Ken H Young. J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851 Free PMC article. Highly Cited. Review.
T-cell Co-inhibitory Molecules in Sepsis-induced Immunosuppression: From Bench to Bedside. Jian-Feng Xie, Hai-Bo Qiu, Yi Yang. Chin Med J (Engl), 2017 May 10; 130(10). PMID: 28485327 Free PMC article.
Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease. Andrew S Flies, Nicholas B Blackburn, +2 authors, Alan Bruce Lyons, John D Hayball, Gregory M Woods. less Front Immunol, 2017 May 19; 8. PMID: 28515726 Free PMC article.
Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1. Elizabeth A McNiel, Philip N Tsichlis. Signal Transduct Target Ther, 2017 May 19; 2. PMID: 28515962 Free PMC article.
Immune Checkpoint in Glioblastoma: Promising and Challenging. Jing Huang, Fangkun Liu, +4 authors, Jindong Chen. less Front Pharmacol, 2017 May 26; 8. PMID: 28536525 Free PMC article. Highly Cited. Review.
Rituximab in Minimal Change Disease: Mechanisms of Action and Hypotheses for Future Studies. Nima Madanchi, Martin Bitzan, Tomoko Takano. Can J Kidney Health Dis, 2017 May 26; 4. PMID: 28540057 Free PMC article. Review.
Targeting the programmed cell death-1 pathway in rheumatoid arthritis. Sabina Sandigursky, Gregg J Silverman, Adam Mor. Autoimmun Rev, 2017 Jun 03; 16(8). PMID: 28572054 Free PMC article. Review.
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy. Roberta Mazzone, Clemens Zwergel, Antonello Mai, Sergio Valente. Clin Epigenetics, 2017 Jun 03; 9. PMID: 28572863 Free PMC article. Highly Cited. Review.
PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells. Carmen Stecher, Claire Battin, +5 authors, Peter Steinberger. less Front Immunol, 2017 Jun 08; 8. PMID: 28588576 Free PMC article.
Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity. Ryu Watanabe, Tsuyoshi Shirai, +9 authors, Cornelia M Weyand. less J Clin Invest, 2017 Jun 13; 127(7). PMID: 28604383 Free PMC article.
OX40 promotes obesity-induced adipose inflammation and insulin resistance. Bing Liu, Hengchi Yu, +11 authors, Dong Zhang. less Cell Mol Life Sci, 2017 Jun 15; 74(20). PMID: 28612217
Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients. Gijsbert P van Nierop, Marvin M van Luijn, +6 authors, Georges M G M Verjans. less Acta Neuropathol, 2017 Jun 19; 134(3). PMID: 28624961 Free PMC article.
Engineering challenges for brain tumor immunotherapy. Johnathan G Lyon, Nassir Mokarram, +2 authors, Tarun Saxena, Sheridan L Carroll, Ravi V Bellamkonda. less Adv Drug Deliv Rev, 2017 Jun 20; 114. PMID: 28625831 Free PMC article. Review.
Genetic alterations in adult T-cell leukemia/lymphoma. Yasunori Kogure, Keisuke Kataoka. Cancer Sci, 2017 Jun 20; 108(9). PMID: 28627735 Free PMC article. Review.
The islet-resident macrophage is in an inflammatory state and senses microbial products in blood. Stephen T Ferris, Pavel N Zakharov, +4 authors, Javier A Carrero. less J Exp Med, 2017 Jun 21; 214(8). PMID: 28630088 Free PMC article.
Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function. Ahmad Faisal Karim, Scott M Reba, +2 authors, Qing Li, W Henry Boom, Roxana E Rojas. less Eur J Immunol, 2017 Jul 01; 47(9). PMID: 28665005 Free PMC article.
Dose-Dependent Responses of I3C and DIM on T-Cell Activation in the Human T Lymphocyte Jurkat Cell Line. Man Liu, Rumana Yasmeen, +3 authors, Thomas T Y Wang. less Int J Mol Sci, 2017 Jul 04; 18(7). PMID: 28671563 Free PMC article.
The emerging role of immune checkpoint based approaches in AML and MDS. Prajwal Boddu, Hagop Kantarjian, +3 authors, Naval Daver. less Leuk Lymphoma, 2017 Jul 07; 59(4). PMID: 28679300 Free PMC article. Review.
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes. Garam Choi, Byung-Seok Kim, +2 authors, Young-Jun Park, Inbo Shim, Yeonseok Chung. less Immune Netw, 2017 Jul 07; 17(3). PMID: 28680377 Free PMC article.
Dendritic Cell Dysfunction in Patients with End-stage Renal Disease. Ji Ung Kim, Miyeon Kim, +5 authors, Hyunwoo Kim. less Immune Netw, 2017 Jul 07; 17(3). PMID: 28680376 Free PMC article. Review.
THEMIS: Two Models, Different Thresholds. Seeyoung Choi, Richard Cornall, Renaud Lesourne, Paul E Love. Trends Immunol, 2017 Jul 13; 38(9). PMID: 28697966 Free PMC article. Review.
Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis. Hyosun Cho, Hyojeung Kang, Hwan Hee Lee, Chang Wook Kim. Int J Mol Sci, 2017 Jul 14; 18(7). PMID: 28703774 Free PMC article. Review.
Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab. Hyun Tae Lee, Ju Yeon Lee, +6 authors, Yong-Seok Heo. less Sci Rep, 2017 Jul 19; 7(1). PMID: 28717238 Free PMC article.
Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis via Targeting Pathogenic Antigen-Specific Th17-Type Cells. Morad Zayoud, Victoria Marcu-Malina, +5 authors, Itamar Goldstein. less Front Immunol, 2017 Jul 25; 8. PMID: 28736556 Free PMC article.
Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40+ monocyte differentiation. Jin Dai, Pu Fang, +8 authors, Hong Wang. less J Hematol Oncol, 2017 Jul 26; 10(1). PMID: 28738836 Free PMC article. Review.
Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines. Namit Holay, Youra Kim, Patrick Lee, Shashi Gujar. Front Immunol, 2017 Jul 29; 8. PMID: 28751892 Free PMC article. Review.
Immunotherapy in Gastrointestinal Cancers. Letizia Procaccio, Marta Schirripa, +9 authors, Sara Lonardi. less Biomed Res Int, 2017 Aug 02; 2017. PMID: 28758114 Free PMC article. Review.
Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization. Di Zhang, Anthony A Armstrong, +4 authors, Mark L Chiu. less MAbs, 2017 Aug 02; 9(7). PMID: 28758875 Free PMC article.
Targeting Immune System Alterations in Hodgkin Lymphoma. Natalie S Grover, Barbara Savoldo. Curr Hematol Malig Rep, 2017 Aug 07; 12(4). PMID: 28780614 Free PMC article. Review.
Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis. Stinne R Greisen, Yan Yan, +7 authors, Bent Deleuran. less Front Immunol, 2017 Aug 10; 8. PMID: 28791012 Free PMC article.
Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models. Melinda Mata, Claudia Gerken, +3 authors, Stephen Gottschalk. less Cancer Discov, 2017 Aug 13; 7(11). PMID: 28801306 Free PMC article.
CD28 and 41BB Costimulation Enhances the Effector Function of CD19-Specific Engager T Cells. Mireya Paulina Velasquez, Arpad Szoor, +5 authors, Stephen Gottschalk. less Cancer Immunol Res, 2017 Aug 20; 5(10). PMID: 28821531 Free PMC article.
Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers. Aaron M Goodman, Shumei Kato, +6 authors, Razelle Kurzrock. less Mol Cancer Ther, 2017 Aug 25; 16(11). PMID: 28835386 Free PMC article. Highly Cited.
PD1 signal transduction pathways in T cells. Hugo Arasanz, Maria Gato-Cañas, +4 authors, David Escors. less Oncotarget, 2017 Sep 09; 8(31). PMID: 28881701 Free PMC article. Highly Cited. Review.
Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells. Khalil Eslamloo, Xi Xue, +5 authors, Matthew L Rise. less BMC Genomics, 2017 Sep 10; 18(1). PMID: 28886690 Free PMC article.
Acute Renal Graft-Versus-Host Disease in a Murine Model of Allogeneic Bone Marrow Transplantation. Peter M Schmid, Abdellatif Bouazzaoui, +5 authors, Dierk H Endemann. less Cell Transplant, 2017 Sep 14; 26(8). PMID: 28901194 Free PMC article.
Peripheral human CD4+CD8+ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15. Marie-Laure Clénet, François Gagnon, +2 authors, Ana Carmena Moratalla, Emilie C Viel, Nathalie Arbour. less Sci Rep, 2017 Sep 16; 7(1). PMID: 28912605 Free PMC article.
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer. Sathana Dushyanthen, Zhi Ling Teo, +15 authors, Sherene Loi. less Nat Commun, 2017 Sep 21; 8(1). PMID: 28928458 Free PMC article.
CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1+ tumor cells, and extends the survival of tumor-bearing humanized mice. Lucas A Horn, Nicholas G Ciavattone, +6 authors, Suzanne Ostrand-Rosenberg. less Oncotarget, 2017 Sep 25; 8(35). PMID: 28938530 Free PMC article.
A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation. Tara Capece, Brandon L Walling, +5 authors, Minsoo Kim. less J Cell Biol, 2017 Sep 29; 216(11). PMID: 28954823 Free PMC article.
Increased Neutralizing Antibody Production and Interferon-γ Secretion in Response to Porcine Reproductive and Respiratory Syndrome Virus Immunization in Genetically Modified Pigs. Guangping Huang, Xianyong Liu, +6 authors, Xun Suo. less Front Immunol, 2017 Sep 29; 8. PMID: 28955336 Free PMC article.
Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis. Devy Deliyanti, Dean M Talia, +8 authors, Jennifer L Wilkinson-Berka. less Nat Commun, 2017 Oct 01; 8(1). PMID: 28963474 Free PMC article.
Proteomics and Network Analyses Reveal Inhibition of Akt-mTOR Signaling in CD4+ T Cells by Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan. Ahmad F Karim, Obondo J Sande, +8 authors, W Henry Boom. less Proteomics, 2017 Oct 11; 17(22). PMID: 28994205 Free PMC article.
Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor. Rachel S Leibman, Max W Richardson, +14 authors, James L Riley. less PLoS Pathog, 2017 Oct 13; 13(10). PMID: 29023549 Free PMC article.
Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction. Jinshui Chen, Yun Song, +4 authors, Peter Buchwald. less J Med Chem, 2017 Oct 13; 60(21). PMID: 29024591 Free PMC article.
A cellular platform for the evaluation of immune checkpoint molecules. Sabrina Jutz, Annika Hennig, +7 authors, Peter Steinberger. less Oncotarget, 2017 Oct 17; 8(39). PMID: 29029399 Free PMC article.
A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia. Shannon K Oda, Andrew W Daman, +5 authors, Philip D Greenberg. less Blood, 2017 Oct 19; 130(22). PMID: 29042364 Free PMC article.
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Catherine B Carbone, Nadja Kern, +4 authors, Ronald D Vale. less Proc Natl Acad Sci U S A, 2017 Oct 19; 114(44). PMID: 29042512 Free PMC article.
Tumor-infiltrating CD8+ lymphocytes predict different clinical outcomes in organ- and non-organ-confined urothelial carcinoma of the bladder following radical cystectomy. Shiqiang Zhang, Jun Wang, Xinyu Zhang, Fangjian Zhou. PeerJ, 2017 Oct 19; 5. PMID: 29043112 Free PMC article.
T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses. Rachel E O'Neill, Wei Du, +6 authors, Xuefang Cao. less J Immunol, 2017 Oct 20; 199(10). PMID: 29046346 Free PMC article.
Analysis of the regulatory function of natural killer cells from patients with systemic lupus erythematosus. D de J Cruz-González, D Gómez-Martin, +5 authors, A E Monsiváis-Urenda. less Clin Exp Immunol, 2017 Oct 24; 191(3). PMID: 29058308 Free PMC article.
A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator. John R Šedý, M Olivia Balmert, +6 authors, Carl F Ware. less J Biol Chem, 2017 Oct 25; 292(51). PMID: 29061848 Free PMC article.
Identification of 14-dehydroergosterol as a novel anti-inflammatory compound inducing tolerogenic dendritic cells. Yasuhisa Ano, Kumiko Ikado, +2 authors, Kazutoshi Shindo, Hideki Koizumi, Daisuke Fujiwara. less Sci Rep, 2017 Oct 27; 7(1). PMID: 29066789 Free PMC article.
Longitudinal assessment of T cell inhibitory receptors in liver transplant recipients and their association with posttransplant infections. Krupa R Mysore, Rafik M Ghobrial, +5 authors, Xian C Li. less Am J Transplant, 2017 Oct 27; 18(2). PMID: 29068155 Free PMC article.
New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review. Joop E Arends, Faydra I Lieveld, Shazaad Ahmad, Andrew Ustianowski. Infect Dis Ther, 2017 Oct 27; 6(4). PMID: 29071665 Free PMC article. Review.
Src-family kinases negatively regulate NFAT signaling in resting human T cells. Alan Baer, Winston Colon-Moran, +2 authors, Jinhua Xiang, Jack T Stapleton, Nirjal Bhattarai. less PLoS One, 2017 Oct 27; 12(10). PMID: 29073235 Free PMC article.
Intestinal Barrier Interactions with Specialized CD8 T Cells. Špela Konjar, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen. Front Immunol, 2017 Oct 28; 8. PMID: 29075263 Free PMC article. Review.
c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals. Christopher D Nishimura, Daniel A Brenner, +9 authors, Caroline Arber. less Blood, 2017 Oct 29; 130(25). PMID: 29079582 Free PMC article.
Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies. Maksim Mamonkin, Malini Mukherjee, +6 authors, Malcolm K Brenner. less Cancer Immunol Res, 2017 Oct 29; 6(1). PMID: 29079655 Free PMC article.
Potential Immunotherapeutics for Immunosuppression in Sepsis. Jinwook Shin, Mirim Jin. Biomol Ther (Seoul), 2017 Oct 31; 25(6). PMID: 29081088 Free PMC article. Review.
Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination. Rafal M Pielak, Geoff P O'Donoghue, +4 authors, Jay T Groves. less Proc Natl Acad Sci U S A, 2017 Nov 01; 114(46). PMID: 29087297 Free PMC article.
Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives. Lidia M Yshii, Reinhard Hohlfeld, Roland S Liblau. Nat Rev Neurol, 2017 Nov 07; 13(12). PMID: 29104289 Review.
Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production. Fanny Polesso, Minhazur Sarker, +2 authors, Arian Anderson, David C Parker, Susan E Murray. less Sci Rep, 2017 Nov 09; 7(1). PMID: 29116141 Free PMC article.
T-cell responses against rhinovirus species A and C in asthmatic and healthy children. Cibele M Gaido, Caitlyn Granland, +4 authors, Belinda J Hales. less Immun Inflamm Dis, 2017 Nov 11; 6(1). PMID: 29124902 Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer. R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs. Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554 Free PMC article. Review.
Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4. Xuan Mo, Hanghang Zhang, +7 authors, M Raza Zaidi. less Cancer Res, 2017 Nov 19; 78(2). PMID: 29150430 Free PMC article.
Diabetes and Sepsis: Risk, Recurrence, and Ruination. Lynn M Frydrych, Fatemeh Fattahi, +2 authors, Katherine He, Peter A Ward, Matthew J Delano. less Front Endocrinol (Lausanne), 2017 Nov 23; 8. PMID: 29163354 Free PMC article. Review.
Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab. Fei Zhang, Xiaoqiang Qi, +9 authors, Ying Zheng. less Oncotarget, 2017 Nov 23; 8(52). PMID: 29163822 Free PMC article.
Checkpoint inhibitors in endometrial cancer: preclinical rationale and clinical activity. Gloria Mittica, Eleonora Ghisoni, +3 authors, Giorgio Valabrega. less Oncotarget, 2017 Nov 23; 8(52). PMID: 29163851 Free PMC article. Review.
Aplastic anemia is related to alterations in T cell receptor signaling. Yankai Xiao, Suwen Zhao, Bo Li. Stem Cell Investig, 2017 Nov 24; 4. PMID: 29167806 Free PMC article. Review.
Introducing Membrane Charge and Membrane Potential to T Cell Signaling. Yuanqing Ma, Kate Poole, Jesse Goyette, Katharina Gaus. Front Immunol, 2017 Nov 25; 8. PMID: 29170669 Free PMC article. Review.
Tumor-targeted costimulation with antibody-fusion proteins improves bispecific antibody-mediated immune response in presence of immunosuppressive factors. Sabrina Sapski, Nadine Beha, Roland Kontermann, Dafne Müller. Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209565 Free PMC article.
Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications. Mariona Cabo, Rienk Offringa, +3 authors, Lorenzo Galluzzi. less Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209572 Free PMC article. Review.
Immunotherapy and gene therapy as novel treatments for cancer. Martha Montserrat Rangel-Sosa, Estuardo Aguilar-Córdova, Augusto Rojas-Martínez. Colomb Med (Cali), 2017 Dec 08; 48(3). PMID: 29213157 Free PMC article. Review.
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling. Sarah E Josefsson, Kanutte Huse, +10 authors, June H Myklebust. less Clin Cancer Res, 2017 Dec 09; 24(4). PMID: 29217528 Free PMC article.
The Future of Immunotherapy: A 20-Year Perspective. David C Wraith. Front Immunol, 2017 Dec 14; 8. PMID: 29234325 Free PMC article.
T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse. Tobias X Dong, Shivashankar Othy, +5 authors, Michael D Cahalan. less Elife, 2017 Dec 15; 6. PMID: 29239725 Free PMC article.
A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages. Camille Danne, Grigory Ryzhakov, +7 authors, Fiona Powrie. less Cell Host Microbe, 2017 Dec 15; 22(6). PMID: 29241040 Free PMC article.
PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy? Sylvain Simon, Nathalie Labarriere. Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296515 Free PMC article. Highly Cited. Review.
Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy. Neus Martinez-Bosch, Judith Vinaixa, Pilar Navarro. Cancers (Basel), 2018 Jan 06; 10(1). PMID: 29301364 Free PMC article. Highly Cited. Review.
Acute stimulation generates Tim-3-expressing T helper type 1 CD4 T cells that persist in vivo and show enhanced effector function. Jacob V Gorman, John D Colgan. Immunology, 2018 Jan 10; 154(3). PMID: 29315553 Free PMC article.
Combined SEP and anti-PD-L1 antibody produces a synergistic antitumor effect in B16-F10 melanoma-bearing mice. Zhengping Hu, Liang Ye, +2 authors, Yingying Xing, Jinhang Hu, Tao Xi. less Sci Rep, 2018 Jan 11; 8(1). PMID: 29317734 Free PMC article.
Improved Cytotoxic T Lymphocyte Responses to Vaccination with Porcine Reproductive and Respiratory Syndrome Virus in 4-1BB Transgenic Pigs. Guangping Huang, Xianyong Liu, +5 authors, Qiuyan Li. less Front Immunol, 2018 Jan 13; 8. PMID: 29326720 Free PMC article.
Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma. Caryn L Elsegood, Janina Ee Tirnitz-Parker, John K Olynyk, George Ct Yeoh. Clin Transl Immunology, 2018 Jan 13; 6(11). PMID: 29326816 Free PMC article. Review.
The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells. Emily N Pawlak, Brennan S Dirk, +2 authors, Jimmy D Dikeakos. less Retrovirology, 2018 Jan 14; 15(1). PMID: 29329537 Free PMC article.
FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody. Di Zhang, Brian Whitaker, Mehabaw G Derebe, Mark L Chiu. MAbs, 2018 Jan 24; 10(3). PMID: 29359992 Free PMC article.
Clinical Development of PD-1 in Advanced Melanoma. Rodrigo Ramella Munhoz, Michael Andrew Postow. Cancer J, 2018 Jan 24; 24(1). PMID: 29360722 Free PMC article. Review.
Clinical Development of PD-1 Blockade in Hematologic Malignancies. Matthew J Pianko, Aaron D Goldberg, Alexander M Lesokhin. Cancer J, 2018 Jan 24; 24(1). PMID: 29360725 Free PMC article. Review.
Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors. Shifaa M Abdin, Dana M Zaher, El-Shaimaa A Arafa, Hany A Omar. Cancers (Basel), 2018 Jan 26; 10(2). PMID: 29370105 Free PMC article. Review.
The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Wenwen Xu, TạMinh Hiếu, Subramaniam Malarkannan, Li Wang. Cell Mol Immunol, 2018 Jan 30; 15(5). PMID: 29375120 Free PMC article. Review.
Multifunctional nanoparticles for cancer immunotherapy: A groundbreaking approach for reprogramming malfunctioned tumor environment. Samaresh Sau, Hashem O Alsaab, +3 authors, Arun K Iyer. less J Control Release, 2018 Feb 03; 274. PMID: 29391232 Free PMC article. Highly Cited. Review.
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis. Eleanor A Fallon, Bethany M Biron-Girard, +4 authors, Alfred Ayala. less J Leukoc Biol, 2018 Feb 03;. PMID: 29393983 Free PMC article. Review.
CD80/CD86 signaling contributes to the proinflammatory response of Staphylococcus aureus in the airway. Dane Parker. Cytokine, 2018 Feb 07; 107. PMID: 29402722 Free PMC article.
Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse. Katarzyna I Jankowska, Edward K Williamson, +4 authors, Janis K Burkhardt. less Front Immunol, 2018 Feb 07; 9. PMID: 29403502 Free PMC article.
Dichotomous roles of co-stimulatory molecules in diabetes mellitus. Ji-Xin Zhong, Jie Chen, Xiaoquan Rao, Lihua Duan. Oncotarget, 2018 Feb 09; 9(2). PMID: 29416823 Free PMC article. Review.
Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection. Carolina Firacative, A Elisabeth Gressler, +5 authors, Gottfried Alber. less Sci Rep, 2018 Feb 10; 8(1). PMID: 29422616 Free PMC article.
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses. Iris Hecht, Amir Toporik, +25 authors, Galit Rotman. less J Immunol, 2018 Feb 13; 200(6). PMID: 29431694 Free PMC article.
GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg. Keman Xu, William Y Yang, +6 authors, Xiaofeng Yang. less Front Immunol, 2018 Feb 13; 9. PMID: 29434588 Free PMC article.
Prognostic value of PD -L1 expression in patients with primary solid tumors. Xiao Xiang, Peng-Cheng Yu, +5 authors, Le-Qun Li. less Oncotarget, 2018 Feb 13; 9(4). PMID: 29435162 Free PMC article.
Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design. Sitanshu S Singh, Seetharama D Jois. Adv Protein Chem Struct Biol, 2018 Feb 21; 111. PMID: 29459028 Free PMC article. Review.
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections. Eleni Panagioti, Paul Klenerman, +2 authors, Lian N Lee, Sjoerd H van der Burg, Ramon Arens. less Front Immunol, 2018 Mar 06; 9. PMID: 29503649 Free PMC article. Review.
B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Ling Chen, Takeshi Azuma, +3 authors, Weiwei Yu, Xu Zheng, Liqun Luo, Lieping Chen. less Proc Natl Acad Sci U S A, 2018 Mar 07; 115(12). PMID: 29507197 Free PMC article.
Role of Polyamines in Immune Cell Functions. Rebecca S Hesterberg, John L Cleveland, Pearlie K Epling-Burnette. Med Sci (Basel), 2018 Mar 09; 6(1). PMID: 29517999 Free PMC article. Review.
Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand? Eros Marín, Maria Cristina Cuturi, Aurélie Moreau. Front Immunol, 2018 Mar 10; 9. PMID: 29520275 Free PMC article. Review.
CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells. Katarina Stanko, Christina Iwert, +11 authors, Birgit Sawitzki. less Proc Natl Acad Sci U S A, 2018 Mar 14; 115(13). PMID: 29531070 Free PMC article.
Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients. Denise C Hsu, Kimberly F Breglio, +12 authors, Irini Sereti. less Clin Infect Dis, 2018 Mar 15; 67(3). PMID: 29538651 Free PMC article.
Next generation of immune checkpoint therapy in cancer: new developments and challenges. Julian A Marin-Acevedo, Bhagirathbhai Dholaria, +3 authors, Yanyan Lou. less J Hematol Oncol, 2018 Mar 17; 11(1). PMID: 29544515 Free PMC article. Highly Cited. Review.
RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells. David Vallois, Aurélie Dupuy, +15 authors, Laurence de Leval. less Haematologica, 2018 Mar 17; 103(8). PMID: 29545337 Free PMC article.
Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer. Taylor T Chrisikos, Yifan Zhou, +3 authors, Haiyan S Li. less Mol Immunol, 2018 Mar 20; 110. PMID: 29549977 Free PMC article. Review.
Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta. Marjolein W J Wentink, Yvonne M Mueller, +5 authors, Peter D Katsikis. less Front Immunol, 2018 Mar 23; 9. PMID: 29563914 Free PMC article.
Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells. Thomas Menter, Alexandar Tzankov. Front Oncol, 2018 Mar 23; 8. PMID: 29564225 Free PMC article. Review.
The Effect of a Competitive Futsal Match on T Lymphocyte Surface Receptor Signaling and Functions. Maria F Cury-Boaventura, Renata Gorjão, +8 authors, Elaine Hatanaka. less Front Physiol, 2018 Mar 31; 9. PMID: 29599721 Free PMC article.
Prediction of treatment responses to neoadjuvant chemotherapy in triple-negative breast cancer by analysis of immune checkpoint protein expression. Yuka Asano, Shinichiro Kashiwagi, +9 authors, Masaichi Ohira. less J Transl Med, 2018 Apr 05; 16(1). PMID: 29615063 Free PMC article.
CD8+ T Cells and NK Cells: Parallel and Complementary Soldiers of Immunotherapy. Jillian Rosenberg, Jun Huang. Curr Opin Chem Eng, 2018 Apr 07; 19. PMID: 29623254 Free PMC article.
A T cell equation as a conceptual model of T cell responses for maximizing the efficacy of cancer immunotherapy. Haidong Dong, Yiyi Yan, Roxana S Dronca, Svetomir N Markovic. SOJ Immunol, 2017 Jan 01; 5(1). PMID: 29629436 Free PMC article.
Programmed self-assembly of peptide-major histocompatibility complex for antigen-specific immune modulation. Chih-Ping Mao, Shiwen Peng, +4 authors, T-C Wu. less Proc Natl Acad Sci U S A, 2018 Apr 11; 115(17). PMID: 29632186 Free PMC article.
S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity. Jinhua Zhang, Kun Song, +6 authors, Zhihai Qin. less Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632708 Free PMC article.
Evaluation of programmed cell death protein 1 (PD-1) expression as a prognostic biomarker in patients with clear cell renal cell carcinoma. Kyu Seo Kim, Rishi R Sekar, +5 authors, Viraj A Master. less Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632730 Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies. Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok. Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946 Free PMC article. Highly Cited. Review.
TGF-β1 expression in regulatory NK1.1-CD4+NKG2D+ T cells dependents on the PI3K-p85α/JNK, NF-κB and STAT3 pathways. Sen Han, Shizhen Ding, +9 authors, Weijuan Gong. less Am J Cancer Res, 2018 Apr 11; 8(3). PMID: 29637003 Free PMC article.
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. Joanne K Gardner, Scott M J Cornwall, +5 authors, Delia J Nelson. less PLoS One, 2018 Apr 14; 13(4). PMID: 29652910 Free PMC article.
Increased vessel perfusion predicts the efficacy of immune checkpoint blockade. Xichen Zheng, Zhaoxu Fang, +17 authors, Yuhui Huang. less J Clin Invest, 2018 Apr 18; 128(5). PMID: 29664018 Free PMC article.
A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy. Yu Mi, Christof C Smith, +5 authors, Andrew Z Wang. less Adv Mater, 2018 Apr 25; 30(25). PMID: 29691900 Free PMC article.
T Cell Calcium Signaling Regulation by the Co-Receptor CD5. Claudia M Tellez Freitas, Deborah K Johnson, K Scott Weber. Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701673 Free PMC article. Review.
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses. Jang Hwan Cho, James J Collins, Wilson W Wong. Cell, 2018 May 01; 173(6). PMID: 29706540 Free PMC article. Highly Cited.
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054. Yiwen Li, Carmine Carpenito, +18 authors, Michael Kalos. less J Immunother Cancer, 2018 May 02; 6(1). PMID: 29712568 Free PMC article.
Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma. Tyler J Wildes, Adam Grippin, +5 authors, Duane A Mitchell. less Clin Cancer Res, 2018 May 02; 24(16). PMID: 29712687 Free PMC article.
Expression of LLT1 and its receptor CD161 in lung cancer is associated with better clinical outcome. Véronique M Braud, Jérôme Biton, +13 authors, Claire Germain. less Oncoimmunology, 2018 May 04; 7(5). PMID: 29721382 Free PMC article.
Immune checkpoint receptors: homeostatic regulators of immunity. Antonio Riva, Shilpa Chokshi. Hepatol Int, 2018 May 10; 12(3). PMID: 29740793 Free PMC article. Review.
Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction. Damir Bojadzic, Jinshui Chen, Oscar Alcazar, Peter Buchwald. Molecules, 2018 May 13; 23(5). PMID: 29751636 Free PMC article.
Efficient Uptake of Recombinant Lipidated Survivin by Antigen-Presenting Cells Initiates Antigen Cross-Presentation and Antitumor Immunity. Chen-Yi Chiang, Yi-Jyun Chen, +3 authors, Hsin-Wei Chen. less Front Immunol, 2018 May 15; 9. PMID: 29755461 Free PMC article.
Effects of Fish Oil on HIV-Related Inflammation and Markers of Immunosenescence: A Randomized Clinical Trial. Barbara Swanson, Joyce Keithley, +5 authors, Anneliese Rosdil. less J Altern Complement Med, 2018 May 16; 24(7). PMID: 29762043 Free PMC article.
Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation. Xinyuan Li, Luqiao Wang, +4 authors, Xiao-Feng Yang. less J Biol Chem, 2018 May 18; 293(28). PMID: 29769317 Free PMC article.
T Cell Co-Stimulation: Inhibition of Immunosuppression? Karl-Gösta Sundqvist. Front Immunol, 2018 May 19; 9. PMID: 29774033 Free PMC article.
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances. Anna Ohradanova-Repic, Christian Machacek, +18 authors, Hannes Stockinger. less Front Immunol, 2018 May 22; 9. PMID: 29780382 Free PMC article.
Helper T-cell responses and pulmonary fungal infections. Andrew J McDermott, Bruce S Klein. Immunology, 2018 May 22; 155(2). PMID: 29781185 Free PMC article. Review.
Aberrant T cell subsets and cytokines expression profile in systemic lupus erythematosus. Haiyan Zhou, Bailong Hu, +8 authors, Joshua Liao. less Clin Rheumatol, 2018 May 23; 37(9). PMID: 29785672
Influenza vaccination of cancer patients during PD-1 blockade induces serological protection but may raise the risk for immune-related adverse events. Heinz Läubli, Catharina Balmelli, +10 authors, Sacha I Rothschild. less J Immunother Cancer, 2018 May 24; 6(1). PMID: 29789020 Free PMC article.
Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2). Zhonghua Pei, Rohan Mendonca, +13 authors, Benjamin D Sellers. less ACS Med Chem Lett, 2018 May 26; 9(5). PMID: 29795752 Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer. Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang. less J Mol Biol, 2018 May 26; 430(14). PMID: 29800567 Free PMC article. Review.
Defining and Understanding Adaptive Resistance in Cancer Immunotherapy. Tae Kon Kim, Roy S Herbst, Lieping Chen. Trends Immunol, 2018 May 29; 39(8). PMID: 29802087 Free PMC article. Highly Cited. Review.
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses. Teresa Nguyen, Naze G Avci, +2 authors, Dong Ho Shin, Naiara Martinez-Velez, Hong Jiang. less Cancers (Basel), 2018 Jun 03; 10(6). PMID: 29857493 Free PMC article. Review.
Murine CMV Expressing the High Affinity NKG2D Ligand MULT-1: A Model for the Development of Cytomegalovirus-Based Vaccines. Lea Hiršl, Ilija Brizić, +5 authors, Stipan Jonjić. less Front Immunol, 2018 Jun 06; 9. PMID: 29867968 Free PMC article.
CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo. Daniela Langenhorst, Stephanie Haack, +5 authors, Niklas Beyersdorf. less Front Immunol, 2018 Jun 06; 9. PMID: 29868020 Free PMC article.
CD4+ T Cell Subsets and Pathways to HIV Latency. Luis M Agosto, Andrew J Henderson. AIDS Res Hum Retroviruses, 2018 Jun 06; 34(9). PMID: 29869531 Free PMC article. Review.
Chitosan Microsphere Used as an Effective System to Deliver a Linked Antigenic Peptides Vaccine Protect Mice Against Acute and Chronic Toxoplasmosis. Jingjing Guo, Xiahui Sun, +6 authors, Hua Cong. less Front Cell Infect Microbiol, 2018 Jun 08; 8. PMID: 29876322 Free PMC article.
APVO210: A Bispecific Anti-CD86-IL-10 Fusion Protein (ADAPTIR™) to Induce Antigen-Specific T Regulatory Type 1 Cells. Laurence Pellerin, Ping Chen, +3 authors, Maria Grazia Roncarolo. less Front Immunol, 2018 Jun 12; 9. PMID: 29887861 Free PMC article.
Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile. Christiane Querfeld, Samantha Leung, +13 authors, James W Young. less Cancer Immunol Res, 2018 Jun 14; 6(8). PMID: 29895574 Free PMC article.
Antitumor Immunity Is Controlled by Tetraspanin Proteins. Fleur Schaper, Annemiek B van Spriel. Front Immunol, 2018 Jun 14; 9. PMID: 29896201 Free PMC article. Review.
Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Norio Chihara, Asaf Madi, +18 authors, Vijay K Kuchroo. less Nature, 2018 Jun 15; 558(7710). PMID: 29899446 Free PMC article. Highly Cited.
Albumin/globulin ratio is negatively correlated with PD-1 and CD25 mRNA levels in breast cancer patients. Chao Liu, Wei Wang, +6 authors, Shikai Wu. less Onco Targets Ther, 2018 Jun 15; 11. PMID: 29899663 Free PMC article.
Current treatment options for psoriatic arthritis: spotlight on abatacept. Francesco Ursini, Emilio Russo, +2 authors, Salvatore D'Angelo. less Ther Clin Risk Manag, 2018 Jun 21; 14. PMID: 29922065 Free PMC article. Review.
Human αβ and γδ T Cells in Skin Immunity and Disease. Michelle S Cruz, Alani Diamond, Astrid Russell, Julie Marie Jameson. Front Immunol, 2018 Jun 22; 9. PMID: 29928283 Free PMC article. Review.
Ligation of Na, K ATPase β3 subunit on monocytes by a specific monoclonal antibody mediates T cell hypofunction. Nuchjira Takheaw, Witida Laopajon, +3 authors, Watchara Kasinrerk. less PLoS One, 2018 Jun 26; 13(6). PMID: 29940031 Free PMC article.
Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review. Waseem Lone, Aisha Alkhiniji, Jayadev Manikkam Umakanthan, Javeed Iqbal. Curr Hematol Malig Rep, 2018 Jun 29; 13(4). PMID: 29951889 Review.
T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice. Jaclyn R Espinosa, Danny Mou, +9 authors, Allan D Kirk. less Front Immunol, 2018 Jul 03; 9. PMID: 29963060 Free PMC article.
CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Vishal Khairnar, Vikas Duhan, +18 authors, Karl S Lang. less Nat Commun, 2018 Jul 04; 9(1). PMID: 29967450 Free PMC article.
Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice. Marco F Taddio, Linjing Mu, +2 authors, Claudia Keller, Roger Schibli, Stefanie D Krämer. less Contrast Media Mol Imaging, 2018 Jul 04; 2018. PMID: 29967572 Free PMC article.
Expression and clinical significance of programmed death ligand 1 in nasopharyngeal carcinoma. Yuan Qu, Di Wang, +3 authors, Lin Yang, Hui-Ying Liu, Wei Cui, Yi-Qun Che. less Mol Clin Oncol, 2018 Jul 07; 9(1). PMID: 29977542 Free PMC article.
Immune Checkpoints as the Immune System Regulators and Potential Biomarkers in HIV-1 Infection. Maike Sperk, Robert van Domselaar, Ujjwal Neogi. Int J Mol Sci, 2018 Jul 11; 19(7). PMID: 29987244 Free PMC article. Review.
Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV Cure. Genevieve Tyndale Clutton, R Brad Jones. Front Immunol, 2018 Jul 11; 9. PMID: 29988382 Free PMC article. Review.
Association of CD28 and CTLA4 haplotypes with susceptibility to primary Sjögren's syndrome in Mexican population. Erika Fabiola López-Villalobos, Francisco Josué Carrillo-Ballesteros, +4 authors, Edith Oregon-Romero. less J Clin Lab Anal, 2018 Jul 12; 33(1). PMID: 29992636 Free PMC article.
Massive parallel screening of phage libraries for the generation of repertoires of human immunomodulatory monoclonal antibodies. Emanuele Sasso, Chiara D'Avino, +9 authors, Claudia De Lorenzo. less MAbs, 2018 Jul 12; 10(7). PMID: 29995563 Free PMC article.
Novel tumour antigens and the development of optimal vaccine design. Victoria A Brentville, Suha Atabani, Katherine Cook, Lindy G Durrant. Ther Adv Vaccines Immunother, 2018 Jul 13; 6(2). PMID: 29998219 Free PMC article. Review.
Microbial biomarkers for immune checkpoint blockade therapy against cancer. Keishi Adachi, Koji Tamada. J Gastroenterol, 2018 Jul 14; 53(9). PMID: 30003334 Free PMC article. Review.
2B4 Mediates Inhibition of CD8+ T Cell Responses via Attenuation of Glycolysis and Cell Division. Sonia J Laurie, Danya Liu, +3 authors, Mandy L Ford. less J Immunol, 2018 Jul 18; 201(5). PMID: 30012849 Free PMC article.
Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways. Alan Baer, Winston Colon-Moran, Nirjal Bhattarai. Sci Rep, 2018 Jul 22; 8(1). PMID: 30026610 Free PMC article.
Review article: systemic treatment of hepatocellular carcinoma. Matthias Pinter, Markus Peck-Radosavljevic. Aliment Pharmacol Ther, 2018 Jul 25; 48(6). PMID: 30039640 Free PMC article. Review.
Pulmonary Infections in Immunocompromised Hosts: Clinical. Cristina Vazquez Guillamet, Joe Le Hsu, Gundeep Dhillon, Rodrigo Vazquez Guillamet. J Thorac Imaging, 2018 Jul 27; 33(5). PMID: 30048345 Free PMC article. Review.
Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective. Somayeh Vandghanooni, Morteza Eskandani, Jaleh Barar, Yadollah Omidi. J Mol Med (Berl), 2018 Jul 30; 96(9). PMID: 30056527 Review.
Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function. Sophie M Poznanski, Nicole G Barra, Ali A Ashkar, Jonathan D Schertzer. Inflamm Res, 2018 Aug 02; 67(10). PMID: 30066126 Review.
Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling. Justin Lucas, Tze-Chen Hsieh, +2 authors, Joseph M Wu. less Int J Oncol, 2018 Aug 02; 53(4). PMID: 30066852 Free PMC article.
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity. Christopher W Helsen, Joanne A Hammill, +14 authors, Jonathan L Bramson. less Nat Commun, 2018 Aug 05; 9(1). PMID: 30076299 Free PMC article.
Neuromuscular Complications of Programmed Cell Death-1 (PD-1) Inhibitors. Justin C Kao, Adipong Brickshawana, Teerin Liewluck. Curr Neurol Neurosci Rep, 2018 Aug 06; 18(10). PMID: 30078154 Review.
Next Generation Cancer Vaccines-Make It Personal! Angelika Terbuch, Juanita Lopez. Vaccines (Basel), 2018 Aug 12; 6(3). PMID: 30096953 Free PMC article. Review.
Producing proT cells to promote immunotherapies. Jastaranpreet Singh, Juan Carlos Zúñiga-Pflücker. Int Immunol, 2018 Aug 14; 30(12). PMID: 30102361 Free PMC article. Review.
A Mechanistic Computational Model Reveals That Plasticity of CD4+ T Cell Differentiation Is a Function of Cytokine Composition and Dosage. Bhanwar Lal Puniya, Robert G Todd, +3 authors, Tomáš Helikar. less Front Physiol, 2018 Aug 18; 9. PMID: 30116195 Free PMC article.
Distinct Changes of BTLA and HVEM Expressions in Circulating CD4+ and CD8+ T Cells in Hepatocellular Carcinoma Patients. Jiayu Liu, Jiaqian Li, +2 authors, Min He, Geng-Lin Zhang, Qiyi Zhao. less J Immunol Res, 2018 Aug 18; 2018. PMID: 30116751 Free PMC article.
Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy. Paola M Dantonio, Marianne O Klein, +3 authors, Ricardo G Correa. less Biosci Rep, 2018 Sep 01; 38(5). PMID: 30166456 Free PMC article. Review.
Prognostic significance of tumor immune microenvironment and immunotherapy: Novel insights and future perspectives in gastric cancer. Daniela Cornelia Lazăr, Mihaela Flavia Avram, +3 authors, Adrian Goldiș. less World J Gastroenterol, 2018 Sep 01; 24(32). PMID: 30166856 Free PMC article. Highly Cited. Review.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity. Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar. J Autoimmun, 2018 Sep 04; 95. PMID: 30174217 Free PMC article. Review.
Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses. Rebecca L Tallmadge, Minghui Wang, Qi Sun, Maria Julia B Felippe. PLoS One, 2018 Sep 06; 13(9). PMID: 30183726 Free PMC article.
Immune checkpoint inhibitors in melanoma. Adam J Cooper, Matteo S Carlino, Richard F Kefford. Melanoma Manag, 2015 Aug 01; 2(3). PMID: 30190854 Free PMC article. Review.
Immune checkpoint inhibitors for hepatocellular carcinoma. Christopher E Jensen, Arturo Loaiza-Bonilla, Paula A Bonilla-Reyes. Hepat Oncol, 2016 Aug 01; 3(3). PMID: 30191042 Free PMC article. Review.
Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS. Takeshi Sugio, Kohta Miyawaki, +8 authors, Koichi Akashi. less Blood Adv, 2018 Sep 09; 2(17). PMID: 30194138 Free PMC article.
New developments in immunotherapy for lymphoma. Benjamin Heyman, Yiping Yang. Cancer Biol Med, 2018 Sep 11; 15(3). PMID: 30197788 Free PMC article.
Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling. Anisur Rahman, Abhinav Tiwari, Jatin Narula, Timothy Hickling. CPT Pharmacometrics Syst Pharmacol, 2018 Sep 11; 7(10). PMID: 30198637 Free PMC article. Review.
PD-1 has a unique capacity to inhibit allergen-specific human CD4+ T cell responses. Sandra Rosskopf, Beatrice Jahn-Schmid, +2 authors, Peter Steinberger. less Sci Rep, 2018 Sep 12; 8(1). PMID: 30201974 Free PMC article.
Present and future of cancer immunotherapy: A tumor microenvironmental perspective. Yu Yu, Jiuwei Cui. Oncol Lett, 2018 Sep 15; 16(4). PMID: 30214551 Free PMC article. Review.
Proximity ligation assay to study protein-protein interactions of proteins on two different cells. Rushikesh Sable, Nithya Jambunathan, +3 authors, Seetharama Jois. less Biotechniques, 2018 Sep 20; 65(3). PMID: 30227746 Free PMC article.
Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans. Sina Fellermeier-Kopf, Friederike Gieseke, +3 authors, Roland E Kontermann. less Oncoimmunology, 2018 Sep 20; 7(9). PMID: 30228940 Free PMC article.
Clostridium novyi-NT in cancer therapy. Verena Staedtke, Nicholas J Roberts, Ren-Yuan Bai, Shibin Zhou. Genes Dis, 2016 Feb 06; 3(2). PMID: 30258882 Free PMC article. Review.
Therapeutic vaccination with 4-1BB co-stimulation eradicates mouse acute myeloid leukemia. Daniel Kerage, Megan S F Soon, +5 authors, Stephen R Mattarollo. less Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288351 Free PMC article.
The comprehensive molecular landscape of the immunologic co-stimulator B7 and TNFR ligand receptor families in colorectal cancer: immunotherapeutic implications with microsatellite instability. Jinghua Tang, Wu Jiang, +5 authors, Yingqin Li. less Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288357 Free PMC article.
A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity. Meinolf Thiemann, David M Richards, +10 authors, Oliver Hill. less Front Oncol, 2018 Oct 10; 8. PMID: 30298117 Free PMC article.
Control of Immunoregulatory Molecules by miRNAs in T Cell Activation. Ana Rodríguez-Galán, Lola Fernández-Messina, Francisco Sánchez-Madrid. Front Immunol, 2018 Oct 16; 9. PMID: 30319616 Free PMC article. Review.
The Role of the Immunological Synapse in Differential Effects of APC Subsets in Alloimmunization to Fresh, Non-stored RBCs. Amanda L Richards, Kathryn Sheldon, +2 authors, Xiaoping Wu, David R Gruber, Krystalyn E Hudson. less Front Immunol, 2018 Oct 23; 9. PMID: 30344520 Free PMC article.
Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling. Theinmozhi Arulraj, Debashis Barik. PLoS One, 2018 Oct 26; 13(10). PMID: 30356330 Free PMC article.
Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy. Hanna A Knaus, Sofia Berglund, +9 authors, Ivana Gojo. less JCI Insight, 2018 Nov 06; 3(21). PMID: 30385732 Free PMC article.
An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion. John D Klement, Amy V Paschall, +7 authors, Kebin Liu. less J Clin Invest, 2018 Nov 06; 128(12). PMID: 30395540 Free PMC article.
MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells. Babita Agrawal, Nancy Gupta, Jeffrey D Konowalchuk. Front Immunol, 2018 Nov 09; 9. PMID: 30405607 Free PMC article. Review.
Combination Immune Checkpoint Blockade Strategies to Maximize Immune Response in Gynecological Cancers. Ying L Liu, Dmitriy Zamarin. Curr Oncol Rep, 2018 Nov 14; 20(12). PMID: 30421009 Free PMC article. Review.
T Cells in Adipose Tissue: Critical Players in Immunometabolism. Qun Wang, Huaizhu Wu. Front Immunol, 2018 Nov 22; 9. PMID: 30459770 Free PMC article. Review.
Novel Treatments in Lupus. Milena Vukelic, Yi Li, Vasileios C Kyttaris. Front Immunol, 2018 Dec 14; 9. PMID: 30524430 Free PMC article. Review.
Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma. Benjamin P Hurrell, Pedram Shafiei Jahani, Omid Akbari. Front Immunol, 2018 Dec 14; 9. PMID: 30524437 Free PMC article. Review.
Herpes Virus Entry Mediator (HVEM) Expression Promotes Inflammation/ Organ Injury in Response to Experimental Indirect-Acute Lung Injury. Tingting Cheng, Jianwen Bai, +3 authors, Alfred Ayala. less Shock, 2018 Dec 12; 51(4). PMID: 30531604 Free PMC article.
The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections. Keiko Yasuma-Mitobe, Masao Matsuoka. Front Immunol, 2018 Dec 13; 9. PMID: 30538707 Free PMC article. Review.
Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells. Julia Krombach, Roman Hennel, +12 authors, Kirsten Lauber. less Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546963 Free PMC article.
A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155. Bushra Husain, Sree R Ramani, +13 authors, Nadia Martinez-Martin. less Mol Cell Proteomics, 2019 Jul 17; 18(11). PMID: 31308249 Free PMC article.
Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. Jie Wang, Keke Fei, +11 authors, Junjian Liu. less MAbs, 2019 Aug 14; 11(8). PMID: 31402780 Free PMC article.
Programmed Death Ligand 1 (PD-L1) as a Predictive Biomarker for Pembrolizumab Therapy in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC). Lorena Incorvaia, Daniele Fanale, +10 authors, Antonio Russo. less Adv Ther, 2019 Aug 23; 36(10). PMID: 31432460 Free PMC article. Review.
Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis. Qian Li, Yan Yan, +8 authors, Mengji Lu. less Front Immunol, 2019 Oct 02; 10. PMID: 31572396 Free PMC article.
Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation. Xiaoli Wang, Sytse J Piersma, +6 authors, Daved H Fremont. less Proc Natl Acad Sci U S A, 2019 Oct 03; 116(42). PMID: 31575740 Free PMC article.
The Role of Immune Checkpoint Receptors in Regulating Immune Reactivity in Lupus. Kun-Lin Lu, Ming-Ying Wu, +4 authors, Chun-Bing Chen. less Cells, 2019 Oct 11; 8(10). PMID: 31597242 Free PMC article. Review.
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention. Anna Aiello, Farzin Farzaneh, +6 authors, Giulia Accardi. less Front Immunol, 2019 Oct 15; 10. PMID: 31608061 Free PMC article. Highly Cited. Review.
Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors. Giuseppe Schepisi, Nicole Brighi, +11 authors, Ugo De Giorgi. less J Oncol, 2019 Oct 24; 2019. PMID: 31641355 Free PMC article. Review.
The Pathogenesis of Sepsis and Potential Therapeutic Targets. Min Huang, Shaoli Cai, Jingqian Su. Int J Mol Sci, 2019 Nov 02; 20(21). PMID: 31671729 Free PMC article. Review.
Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells. Trine B Levring, Martin Kongsbak-Wismann, +7 authors, Carsten Geisler. less Sci Rep, 2019 Nov 15; 9(1). PMID: 31723203 Free PMC article.
Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer. So Mee Kwon, Anuradha Budhu, +10 authors, Xin Wei Wang. less Sci Rep, 2019 Nov 16; 9(1). PMID: 31729408 Free PMC article.
Hypomethylating agents in combination with immune checkpoint inhibitors in acute myeloid leukemia and myelodysplastic syndromes. Naval Daver, Prajwal Boddu, +4 authors, Hagop Kantarjian. less Leukemia, 2018 Mar 01; 32(5). PMID: 29487386 Free PMC article. Highly Cited. Review.
OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling. Prabhakaran Kumar, Swarali Surendra Lele, +4 authors, Bellur S Prabhakar. less J Immunol, 2019 Nov 11; 203(12). PMID: 31704879 Free PMC article.
Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition. Rita C Acúrcio, Carlota Leonardo-Sousa, +3 authors, Rita C Guedes. less Medchemcomm, 2019 Dec 10; 10(10). PMID: 31814954 Free PMC article.
Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors. Bin Lai, Jiwei Wang, +28 authors, Xiaofeng Yang. less Front Immunol, 2019 Dec 12; 10. PMID: 31824480 Free PMC article.
Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer. Robert S Svatek, Niannian Ji, +12 authors, Tyler J Curiel. less Cancer Immunol Res, 2018 Dec 20; 7(3). PMID: 30563829 Free PMC article.
Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer. Katsiaryna Marhelava, Zofia Pilch, +2 authors, Radoslaw Zagozdzon. less Cancers (Basel), 2019 Nov 14; 11(11). PMID: 31717326 Free PMC article. Review.
A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Marcus J Taylor, Kabir Husain, +2 authors, Zev J Gartner, Satyajit Mayor, Ronald D Vale. less Cell, 2017 Mar 25; 169(1). PMID: 28340336 Free PMC article. Highly Cited.
An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability. Tomasz Slezak, Lucas J Bailey, +4 authors, Anthony A Kossiakoff. less Protein Sci, 2019 Oct 18; 29(1). PMID: 31622515 Free PMC article.
Checkpoint Genes at the Cancer Side of the Immunological Synapse in Bladder Cancer. Paula Dobosz, Przemysław A Stempor, +6 authors, Raya Leibowitz-Amit. less Transl Oncol, 2019 Dec 24; 13(2). PMID: 31869744 Free PMC article.
Immunology of Adenoviral Vectors in Cancer Therapy. Amanda Rosewell Shaw, Masataka Suzuki. Mol Ther Methods Clin Dev, 2020 Jan 01; 15. PMID: 31890734 Free PMC article. Review.
Genetic and Molecular Biology of Multiple Sclerosis Among Iranian Patients: An Overview. Meysam Moghbeli. Cell Mol Neurobiol, 2019 Sep 05; 40(1). PMID: 31482432 Review.
Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Hao Shi, Nicole M Chapman, +10 authors, Hongbo Chi. less Immunity, 2019 Nov 02; 51(6). PMID: 31668641 Free PMC article.
Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells. Yeni Romero, Randi Wise, Anna Zolkiewska. Cancer Immunol Immunother, 2019 Dec 05; 69(1). PMID: 31796994 Free PMC article.
B-cell-specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasion. Daniela Asslaber, Yuan Qi, +7 authors, Alexander Egle. less Blood, 2019 Sep 21; 134(20). PMID: 31537531 Free PMC article.
CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas. Kati Tormanen, Shaohui Wang, Homayon Ghiasi. J Virol, 2019 Oct 18; 94(2). PMID: 31619558 Free PMC article.
Differential Expression of Immune Checkpoint Molecules on CD8+ T Cells Specific for Immunodominant and Subdominant Herpes Simplex Virus 1 Epitopes. Kate L Carroll, Lyndsay Avery, +4 authors, Anthony J St Leger. less J Virol, 2019 Oct 28; 94(2). PMID: 31645447 Free PMC article.
Herbal Medicines Attenuate PD-L1 Expression to Induce Anti-Proliferation in Obesity-Related Cancers. Yu-Chen S H Yang, Zi-Lin Li, +5 authors, Kuan Wang. less Nutrients, 2019 Dec 11; 11(12). PMID: 31817534 Free PMC article. Review.
Immune Response in Bacterial and Candida Sepsis. Patricia Patricio, José Artur Paiva, Luís Miguel Borrego. Eur J Microbiol Immunol (Bp), 2020 Jan 15; 9(4). PMID: 31934361 Free PMC article. Review.
Peptide-based targeting of immunosuppressive cells in cancer. Noah T Trac, Eun Ji Chung. Bioact Mater, 2020 Jan 21; 5(1). PMID: 31956738 Free PMC article. Review.
Enhanced STAT3 phosphorylation and PD-L1 expression in myeloid dendritic cells indicate impaired IL-27Ralpha signaling in type 1 diabetes. Z Parackova, P Vrabcova, +6 authors, A Sediva. less Sci Rep, 2020 Jan 18; 10(1). PMID: 31949260 Free PMC article.
Antibody Structure and Function: The Basis for Engineering Therapeutics. Mark L Chiu, Dennis R Goulet, Alexey Teplyakov, Gary L Gilliland. Antibodies (Basel), 2019 Dec 11; 8(4). PMID: 31816964 Free PMC article. Review.
CD19 CAR T Cells for the Treatment of Pediatric Pre-B Cell Acute Lymphoblastic Leukemia. Holly L Pacenta, Theodore W Laetsch, Samuel John. Paediatr Drugs, 2019 Nov 22; 22(1). PMID: 31749131
Structural insight into T cell coinhibition by PD-1H (VISTA). Benjamin T Slater, Xue Han, Lieping Chen, Yong Xiong. Proc Natl Acad Sci U S A, 2020 Jan 11; 117(3). PMID: 31919279 Free PMC article.
IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors. Jonathan H DeLong, Aisling O'Hara Hall, +8 authors, Christopher A Hunter. less Immunohorizons, 2019 Jul 30; 3(1). PMID: 31356173 Free PMC article.
Surface protein imputation from single cell transcriptomes by deep neural networks. Zilu Zhou, Chengzhong Ye, Jingshu Wang, Nancy R Zhang. Nat Commun, 2020 Feb 02; 11(1). PMID: 32005835 Free PMC article.
Immunotherapy Is Changing First-Line Treatment of Metastatic Renal-Cell Carcinoma. Matthew K Labriola, Kristen A Batich, +5 authors, Tian Zhang. less Clin Genitourin Cancer, 2019 Mar 13; 17(3). PMID: 30858035 Free PMC article. Review.
Methylation of immune synapse genes modulates tumor immunogenicity. Anders Berglund, Matthew Mills, +3 authors, Sungjune Kim. less J Clin Invest, 2019 Nov 13; 130(2). PMID: 31714899 Free PMC article.
Multiscale network analysis reveals molecular mechanisms and key regulators of the tumor microenvironment in gastric cancer. Won-Min Song, Xiandong Lin, +9 authors, Bin Zhang. less Int J Cancer, 2019 Aug 30; 146(5). PMID: 31463974 Free PMC article.
T-cell exhaustion in HIV infection. Craig Fenwick, Victor Joo, +4 authors, Giuseppe Pantaleo. less Immunol Rev, 2019 Dec 29; 292(1). PMID: 31883174 Free PMC article. Review.
Immune checkpoint-based therapy in myeloid malignancies: a promise yet to be fulfilled. Jan Philipp Bewersdorf, Maximilian Stahl, Amer M Zeidan. Expert Rev Anticancer Ther, 2019 Mar 20; 19(5). PMID: 30887841 Free PMC article. Review.
Toxoplasma: Immunity and Pathogenesis. Imtiaz A Khan, Charlotte Ouellette, Keer Chen, Magali Moretto. Curr Clin Microbiol Rep, 2019 Jun 11; 6(1). PMID: 31179204 Free PMC article.
Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer. Kristin G Anderson, Valentin Voillet, +9 authors, Philip D Greenberg. less Cancer Immunol Res, 2019 Jul 25; 7(9). PMID: 31337659 Free PMC article.
Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features. Eva Karamitopoulou. Br J Cancer, 2019 May 22; 121(1). PMID: 31110329 Free PMC article. Review.
Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity. Hélène G Bazin, Laura S Bess, +5 authors, Jay T Evans. less Bioorg Med Chem Lett, 2020 Feb 01; 30(6). PMID: 32001135 Free PMC article.
Immune Dysregulation in HFpEF: A Target for Mesenchymal Stem/Stromal Cell Therapy. Ruxandra I Sava, Carl J Pepine, Keith L March. J Clin Med, 2020 Jan 23; 9(1). PMID: 31963368 Free PMC article. Review.
EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients. Gongmin Zhu, Lijiao Pei, Yuan Li, Xin Gou. Aging (Albany NY), 2020 Feb 06; 12(3). PMID: 32012118 Free PMC article.
A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors. Anna Konstorum, Anthony T Vella, Adam J Adler, Reinhard C Laubenbacher. Sci Rep, 2019 Jul 28; 9(1). PMID: 31350431 Free PMC article.
Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance. Radhika R Gudi, Subha Karumuthil-Melethil, +2 authors, Nicolas Perez, Gongbo Li, Chenthamarakshan Vasu. less Sci Rep, 2019 Aug 21; 9(1). PMID: 31427630 Free PMC article.
Complex human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on germinal center T and B cells. Angelika Schmidt, Johanna E Huber, +6 authors, Dirk Baumjohann. less EBioMedicine, 2020 Mar 03; 53. PMID: 32114393 Free PMC article.
STING, DCs and the link between innate and adaptive tumor immunity. Ralph E Vatner, Edith M Janssen. Mol Immunol, 2017 Dec 24; 110. PMID: 29273394 Free PMC article. Review.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy. Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han. J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595 Free PMC article. Highly Cited. Review.
In vitro evaluation of dual-antigenic PV1 peptide vaccine in head and neck cancer patients. San Jiun Chai, Sammuel Chee Yong Fong, +11 authors, Kue Peng Lim. less Hum Vaccin Immunother, 2018 Sep 08; 15(1). PMID: 30193086 Free PMC article.
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells. Dominik Aschenbrenner, Mathilde Foglierini, +6 authors, Federica Sallusto. less Nat Immunol, 2018 Sep 12; 19(10). PMID: 30201991 Free PMC article.
The challenges of checkpoint inhibition in the treatment of multiple myeloma. Barry Paul, Shuqi Kang, Zhihong Zheng, Yubin Kang. Cell Immunol, 2018 Oct 22; 334. PMID: 30342750 Free PMC article. Review.
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. Vincent A Laufer, Hemant K Tiwari, +12 authors, S Louis Bridges. less Hum Mol Genet, 2018 Nov 14; 28(5). PMID: 30423114 Free PMC article.
Biological Consequences of MHC-II Expression by Tumor Cells in Cancer. Margaret L Axelrod, Rebecca S Cook, Douglas B Johnson, Justin M Balko. Clin Cancer Res, 2018 Nov 23; 25(8). PMID: 30463850 Free PMC article. Review.
Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes. Kimberly N Smitheman, Tesa M Severson, +17 authors, Helai P Mohammad. less Haematologica, 2018 Dec 06; 104(6). PMID: 30514804 Free PMC article.
Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation. Yao Chen, Ryan Zander, +2 authors, Achia Khatun, David M Schauder, Weiguo Cui. less Front Immunol, 2018 Dec 26; 9. PMID: 30581433 Free PMC article. Review.
The Role of Co-stimulatory/Co-inhibitory Signals in Graft-vs.-Host Disease. Sandeep Kumar, Nicholas D Leigh, Xuefang Cao. Front Immunol, 2019 Jan 11; 9. PMID: 30627129 Free PMC article. Review.
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma. Sarah E Josefsson, Klaus Beiske, +12 authors, June H Myklebust. less Cancer Immunol Res, 2019 Jan 20; 7(3). PMID: 30659053 Free PMC article.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function. Takayuki Imanishi, Midori Unno, +11 authors, Takashi Saito. less Life Sci Alliance, 2019 Jan 27; 2(1). PMID: 30683688 Free PMC article.
CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70. Julia M Laufer, Ilona Kindinger, +2 authors, Marc Artinger, Andreas Pauli, Daniel F Legler. less Front Immunol, 2019 Jan 30; 9. PMID: 30692994 Free PMC article.
Concise Review: Skeletal Muscle as a Delivery Route for Mesenchymal Stromal Cells. Shiva Hamidian Jahromi, John E Davies. Stem Cells Transl Med, 2019 Feb 06; 8(5). PMID: 30720934 Free PMC article. Review.
Peripheral T cell receptor beta immune repertoire is promptly reconstituted after acute myocardial infarction. Dan Li, Longgang Hu, +4 authors, Kejia Wang. less J Transl Med, 2019 Feb 08; 17(1). PMID: 30728066 Free PMC article.
Immune checkpoint inhibitors. Enfu Hui. J Cell Biol, 2019 Feb 15; 218(3). PMID: 30760493 Free PMC article. Review.
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells. Jessica Bourque, Daniel Hawiger. Crit Rev Immunol, 2019 Feb 23; 38(5). PMID: 30792568 Free PMC article. Highly Cited. Review.
B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes. Peter S Linsley, Carla J Greenbaum, +2 authors, Cate Speake, S Alice Long, Matthew J Dufort. less JCI Insight, 2019 Mar 05; 4(4). PMID: 30830871 Free PMC article.
Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Jung-Chen Lin, Chen-Ying Chien, +9 authors, Che-Ming J Hu. less Nat Commun, 2019 Mar 07; 10(1). PMID: 30837473 Free PMC article.
Isolation of B-cells using Miltenyi MACS bead isolation kits. Dannielle K Moore, Bongani Motaung, +3 authors, SU-IRG Consortium. less PLoS One, 2019 Mar 21; 14(3). PMID: 30893384 Free PMC article.
Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity. Yu Fujita, Roberto Tinoco, +2 authors, Yan Li, Daniela Senft, Ze'ev A Ronai. less Trends Mol Med, 2019 Mar 23; 25(5). PMID: 30898473 Free PMC article. Review.
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States. Spencer C Wei, Roshan Sharma, +8 authors, James P Allison. less Immunity, 2019 Mar 31; 50(4). PMID: 30926234 Free PMC article.
Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity. Rojan Shrestha, Sarah C Garrett, Steven C Almo, Andras Fiser. Structure, 2019 Apr 02; 27(5). PMID: 30930066 Free PMC article.
CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis. Hui Zhang, Ryu Watanabe, +3 authors, Cornelia M Weyand. less J Am Coll Cardiol, 2019 Apr 13; 73(14). PMID: 30975299 Free PMC article.
Weaponizing T-cell receptors through molecular engineering. Elissa K Leonard, Michael I Leff, Jamie B Spangler. J Biol Chem, 2019 Apr 14; 294(15). PMID: 30979848 Free PMC article.
Emerging therapies for non-small cell lung cancer. Chao Zhang, Natasha B Leighl, Yi-Long Wu, Wen-Zhao Zhong. J Hematol Oncol, 2019 Apr 27; 12(1). PMID: 31023335 Free PMC article. Highly Cited. Review.
Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo. Fadi Issa, Kate Milward, +3 authors, Joanna Hester. less Front Immunol, 2019 May 10; 10. PMID: 31068951 Free PMC article.
Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity. Xinyue Qi, Fanlin Li, +4 authors, Xuanming Yang. less Nat Commun, 2019 May 21; 10(1). PMID: 31105267 Free PMC article.
Toxoplasma gondii: CD8 T Cells Cry for CD4 Help. Imtiaz A Khan, SuJin Hwang, Magali Moretto. Front Cell Infect Microbiol, 2019 May 24; 9. PMID: 31119107 Free PMC article. Review.
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B7-CD28 gene family expression is associated with prognostic and immunological characteristics of diffuse large B-cell lymphoma. Gangjian Wang, Xiaorui Fu, +7 authors, Mingzhi Zhang. less Aging (Albany NY), 2019 Jun 14; 11(12). PMID: 31195368 Free PMC article.
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Clinical Scenarios Emerging from Combined Immunophenotypic, Molecular and Morphologic Analysis of Pancreatic Cancer: The Good, the Bad and the Ugly Scenario. Eva Karamitopoulou, Beat Gloor. Cancers (Basel), 2019 Jul 13; 11(7). PMID: 31295960 Free PMC article. Review.
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A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq. Angela C Boroughs, Rebecca C Larson, +17 authors, Marcela V Maus. less Mol Ther, 2020 Aug 07; 28(12). PMID: 32755564 Free PMC article.
Biomarker Development for Metastatic Renal Cell Carcinoma: Omics, Antigens, T-cells, and Beyond. Benjamin Miron, David Xu, Matthew Zibelman. J Pers Med, 2020 Nov 19; 10(4). PMID: 33202724 Free PMC article. Review.
Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism. Volker Schirrmacher. Biomedicines, 2020 Dec 04; 8(11). PMID: 33266387 Free PMC article. Review.
Dynamical Boolean Modeling of Immunogenic Cell Death. Andrea Checcoli, Jonathan G Pol, +6 authors, Gautier Stoll. less Front Physiol, 2020 Dec 08; 11. PMID: 33281620 Free PMC article.
4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells. Qiang Dai, Ping Han, +6 authors, Xuanming Yang. less Front Immunol, 2020 Dec 08; 11. PMID: 33281809 Free PMC article.
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy. Yuka Igarashi, Tetsuro Sasada. J Immunol Res, 2020 Dec 08; 2020. PMID: 33282961 Free PMC article. Review.
T-cell responses and therapies against SARS-CoV-2 infection. Salman M Toor, Reem Saleh, +2 authors, Eyad Elkord. less Immunology, 2020 Sep 17; 162(1). PMID: 32935333 Free PMC article. Review.
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors. Vid Leko, Steven A Rosenberg. Cancer Cell, 2020 Aug 22; 38(4). PMID: 32822573 Free PMC article. Review.
Biotherapeutic Antibodies for the Treatment of Head and Neck Cancer: Current Approaches and Future Considerations of Photothermal Therapies. Mohammed M Al Qaraghuli. Front Oncol, 2020 Dec 17; 10. PMID: 33324546 Free PMC article. Review.
The Adipocyte and Adaptive Immunity. Jianfeng Song, Tuo Deng. Front Immunol, 2020 Dec 18; 11. PMID: 33329579 Free PMC article. Review.
Overexpression of CD155 is associated with PD-1 and PD-L1 expression on immune cells, rather than tumor cells in the breast cancer microenvironment. Rui-Bin Wang, Yu-Chen Li, +6 authors, Bin Zhu. less World J Clin Cases, 2020 Dec 22; 8(23). PMID: 33344592 Free PMC article.
4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39+ CD8 T cells from primary and metastatic sites of epithelial ovarian cancers. Galam Leem, Junsik Park, +12 authors, Su-Hyung Park. less J Immunother Cancer, 2020 Dec 19; 8(2). PMID: 33335029 Free PMC article.
The immune system view of the coronavirus SARS-CoV-2. Ivana Celardo, Luigia Pace, +2 authors, Loredana Cifaldi, Carlo Gaudio, Vincenzo Barnaba. less Biol Direct, 2020 Dec 30; 15(1). PMID: 33371901 Free PMC article. Review.
The Anticancer Potential of T Cell Receptor-Engineered T Cells. Matyas Ecsedi, Megan S McAfee, Aude G Chapuis. Trends Cancer, 2020 Sep 30; 7(1). PMID: 32988787 Free PMC article. Review.
Patients with systemic lupus erythematosus show increased proportions of CD19+CD20- B cells and secretion of related autoantibodies. Qingqing Zhu, Yun Li, +8 authors, Changhao Xie. less Clin Rheumatol, 2020 Jun 17; 40(1). PMID: 32542581
From biomarkers to therapeutic targets: the promise of PD-L1 in thyroid autoimmunity and cancer. Grégoire D'Andréa, Sandra Lassalle, +2 authors, Nicolas Guevara, Baharia Mograbi, Paul Hofman. less Theranostics, 2021 Jan 05; 11(3). PMID: 33391536 Free PMC article. Review.
Targeting TGFβ signal transduction for cancer therapy. Sijia Liu, Jiang Ren, Peter Ten Dijke. Signal Transduct Target Ther, 2021 Jan 09; 6(1). PMID: 33414388 Free PMC article. Review.
Association of OX40 gene polymorphisms (rs17568G/A and rs229811A/C) with head and neck squamous cell carcinoma. Zahra Faghih, Shabnam Abtahi, +2 authors, Bijan Khademi, Farzaneh Nikfarjam, Nasrollah Erfani. less Mol Biol Rep, 2019 Mar 30; 46(3). PMID: 30923998
CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice. Cheng Ye, Benjamin E Low, +3 authors, John P Driver. less J Immunol, 2020 Sep 02; 205(7). PMID: 32868408 Free PMC article.
The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy. Anastasia Mpakali, Efstratios Stratikos. Cancers (Basel), 2021 Jan 08; 13(1). PMID: 33406696 Free PMC article. Review.
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity. Dan Lu, Liang Liu, +14 authors, Yuxin Yin. less Nat Immunol, 2020 Jan 15; 21(3). PMID: 31932812
The transcription factor Zfp281 sustains CD4+ T lymphocyte activation through directly repressing Ctla-4 transcription. Jing Guo, Zhonghui Xue, +9 authors, Lie Wang. less Cell Mol Immunol, 2019 Sep 13; 17(12). PMID: 31511645 Free PMC article.
TRAIL regulates T cell activation and suppresses inflammation in autoimmune diseases. I-Tsu Chyuan, Ping-Ning Hsu. Cell Mol Immunol, 2020 Mar 27; 17(12). PMID: 32210394 Free PMC article.
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation. Masahiro Kiuchi, Atsushi Onodera, +8 authors, Toshinori Nakayama. less J Exp Med, 2021 Jan 13; 218(4). PMID: 33433611 Free PMC article.
The Combinatorial Effect of Cisplatin and Moxibustion on Tumor Growth Inhibition with Special Reference to Modulation of the Immune Microenvironment in Lewis Lung Cancer Mice. Bin Wang, Jin Huang, +10 authors, Yi Guo. less Evid Based Complement Alternat Med, 2021 Jan 19; 2020. PMID: 33456484 Free PMC article.
Immunobiology of T Cells in Sjögren's Syndrome. Yuan Yao, Jin-Fen Ma, +4 authors, Zhe-Xiong Lian. less Clin Rev Allergy Immunol, 2020 May 12; 60(1). PMID: 32390096 Review.
Multiregion single-cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer. Wei Wang, Yu Zhong, +26 authors, Xueqing Yao. less Clin Transl Med, 2021 Jan 20; 11(1). PMID: 33463049 Free PMC article.
Functional Heterogeneity and Therapeutic Targeting of Tissue-Resident Memory T Cells. Esmé T I van der Gracht, Felix M Behr, Ramon Arens. Cells, 2021 Jan 21; 10(1). PMID: 33467606 Free PMC article. Review.
Immune regulation in renal inflammation. Katrin Neumann, Gisa Tiegs. Cell Tissue Res, 2021 Jan 27; 385(2). PMID: 33496881 Free PMC article. Review.
Determining Factors in the Therapeutic Success of Checkpoint Immunotherapies against PD-L1 in Breast Cancer: A Focus on Epithelial-Mesenchymal Transition Activation. Mariana Segovia-Mendoza, Susana Romero-Garcia, Cristina Lemini, Heriberto Prado-Garcia. J Immunol Res, 2021 Jan 29; 2021. PMID: 33506060 Free PMC article. Review.
Mining The Cancer Genome Atlas database for tumor mutation burden and its clinical implications in gastric cancer. Dong-Yan Zhao, Xi-Zhen Sun, Shu-Kun Yao. World J Gastrointest Oncol, 2021 Jan 30; 13(1). PMID: 33510848 Free PMC article.
Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. Guillem Angulo, Jelena Zeleznjak, +8 authors, Ana Angulo. less Elife, 2021 Jan 19; 10. PMID: 33459589 Free PMC article.
Engineering advanced logic and distributed computing in human CAR immune cells. Jang Hwan Cho, Atsushi Okuma, +3 authors, Wilson W Wong. less Nat Commun, 2021 Feb 06; 12(1). PMID: 33542232 Free PMC article.
Development and Use of the Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy Axicabtagene Ciloleucel in Large B-Cell Lymphoma: A Review. Frederick L Locke, William Y Go, Sattva S Neelapu. JAMA Oncol, 2019 Nov 08; 6(2). PMID: 31697310 Free PMC article. Review.
The BTLA and PD-1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood γδ T cells. Hyun J Hwang, Jae J Lee, +7 authors, Nayoung Kim. less Immun Inflamm Dis, 2020 Dec 18; 9(1). PMID: 33332777 Free PMC article.
Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy. Ariel Isser, Natalie K Livingston, Jonathan P Schneck. Biomaterials, 2020 Dec 19; 268. PMID: 33338931 Free PMC article. Review.
The Updated Status and Future Direction of Immunotherapy Targeting B7-H1/PD-1 in Osteosarcoma. Meng-Ke Fan, Li-Li Qi, Qi Zhang, Ling Wang. Cancer Manag Res, 2021 Feb 05; 13. PMID: 33536783 Free PMC article. Review.
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. Riyao Yang, Linlin Sun, +14 authors, Mien-Chie Hung. less Nat Commun, 2021 Feb 07; 12(1). PMID: 33547304 Free PMC article.
Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models. Jordi Guiteras, Laura De Ramon, +10 authors, Joan Torras. less Int J Mol Sci, 2021 Feb 04; 22(3). PMID: 33530581 Free PMC article.
Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types. Mayanne M T Zhu, Samantha Burugu, +5 authors, Torsten O Nielsen. less Mod Pathol, 2020 May 01; 33(9). PMID: 32350416
Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT. Xiaowen Zhou, Jiangfeng Du, +12 authors, Yanfeng Gao. less Cell Commun Signal, 2021 Feb 10; 19(1). PMID: 33557880 Free PMC article.
Current understanding of cancer-intrinsic PD-L1: regulation of expression and its protumoral activity. Pedram Yadollahi, You-Kyoung Jeon, Wooi Loon Ng, Inhak Choi. BMB Rep, 2020 Dec 11; 54(1). PMID: 33298250 Free PMC article. Review.
αβγδ T cells play a vital role in fetal human skin development and immunity. René Reitermaier, Thomas Krausgruber, +16 authors, Adelheid Elbe-Bürger. less J Exp Med, 2021 Feb 10; 218(4). PMID: 33561194 Free PMC article.
PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma. Naoya Maekawa, Satoru Konnai, +16 authors, Kazuhiko Ohashi. less NPJ Precis Oncol, 2021 Feb 14; 5(1). PMID: 33580183 Free PMC article.
Influence of aging on T cell response and renin-angiotensin system imbalance during SARS-CoV-2 infection. Jorge Quarleri, Cintia Cevallos, M Victoria Delpino. Immunol Lett, 2021 Feb 14; 232. PMID: 33581170 Free PMC article. Review.
Immune Checkpoint-Related Gene Polymorphisms Are Associated With Primary Immune Thrombocytopenia. Shuwen Wang, Xiaoyu Zhang, +8 authors, Xiang Hu. less Front Immunol, 2021 Feb 16; 11. PMID: 33584705 Free PMC article.
Immunotherapeutic advances in gastric cancer. Akira Yoneda, Tamotsu Kuroki, Susumu Eguchi. Surg Today, 2021 Feb 17; 51(11). PMID: 33590326 Review.
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. Rebekka Duhen, Carmen Ballesteros-Merino, +12 authors, Andrew D Weinberg. less Nat Commun, 2021 Feb 18; 12(1). PMID: 33594075 Free PMC article.
B7-H3 is spliced by SRSF3 in colorectal cancer. Chunxia Zhang, Yinshuang Chen, +5 authors, Weipeng Wang. less Cancer Immunol Immunother, 2020 Jul 29; 70(2). PMID: 32719950
Anti-Mesothelin CAR T cell therapy for malignant mesothelioma. Laura Castelletti, Dannel Yeo, Nico van Zandwijk, John E J Rasko. Biomark Res, 2021 Feb 17; 9(1). PMID: 33588928 Free PMC article. Review.
Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation. Kingsley Gideon Kumashie, Marcin Cebula, +5 authors, Dagmar Wirth. less Front Immunol, 2021 Feb 23; 11. PMID: 33613516 Free PMC article.
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway. Tsukasa Oda, Ruri Nakamura, +6 authors, Takayuki Yamashita. less Cancer Gene Ther, 2021 Feb 24; 29(2). PMID: 33619341
The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA. Asif A Dar, Keisuke Sawada, +8 authors, Paula M Oliver. less PLoS Biol, 2021 Feb 02; 19(2). PMID: 33524014 Free PMC article.
Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment. Lesang Shen, Yunxiang Zhou, +6 authors, Jian Huang. less Oxid Med Cell Longev, 2021 Feb 26; 2021. PMID: 33628389 Free PMC article. Review.
Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance. Qian Yang, Ruijing Zhang, +16 authors, Xiaofeng Yang. less J Immunol Res, 2021 Feb 26; 2021. PMID: 33628851 Free PMC article.
Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy. Weiqin Jiang, Yinjun He, +9 authors, Hanju Hua. less Front Immunol, 2021 Feb 27; 11. PMID: 33633741 Free PMC article. Review.
Clinical significance of CD28 gene-related activating alterations in adult T-cell leukaemia/lymphoma. Yuma Sakamoto, Takashi Ishida, +10 authors, Hiroshi Inagaki. less Br J Haematol, 2020 Nov 19; 192(2). PMID: 33205842 Free PMC article.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms. Javid Moslehi, Andrew H Lichtman, +2 authors, Arlene H Sharpe, Lorenzo Galluzzi, Richard N Kitsis. less J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548 Free PMC article. Review.
ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis. Timoteo Marchini, Sophie Hansen, Dennis Wolf. Cells, 2021 Mar 07; 10(2). PMID: 33669769 Free PMC article. Review.
TNF in the era of immune checkpoint inhibitors: friend or foe? Allen Y Chen, Jedd D Wolchok, Anne R Bass. Nat Rev Rheumatol, 2021 Mar 10; 17(4). PMID: 33686279 Free PMC article. Review.
Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study. Qinchuan Wang, Yuanqing Ye, +6 authors, Xifeng Wu. less Cancer Immunol Immunother, 2020 Sep 11; 70(3). PMID: 32909077 Free PMC article.
Effective Activation and Expansion of Canine Lymphocytes Using a Novel Nano-Sized Magnetic Beads Approach. Iwona Monika Szopa, Monika Granica, +4 authors, Kinga Majchrzak-Kuligowska. less Front Immunol, 2021 Mar 09; 12. PMID: 33679741 Free PMC article.
In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET. Marco F Taddio, Claudia A Castro Jaramillo, +8 authors, Stefanie D Krämer. less Mol Imaging Biol, 2020 Sep 30; 23(2). PMID: 32989622 Free PMC article.
Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. Yuan Hong, Yingcai Feng, +12 authors, Ye Liu. less FEBS Open Bio, 2021 Feb 03; 11(3). PMID: 33527708 Free PMC article.
Biomechanics of T Cell Dysfunctions in Chronic Diseases. Sachith D Gunasinghe, Newton G Peres, Jesse Goyette, Katharina Gaus. Front Immunol, 2021 Mar 16; 12. PMID: 33717081 Free PMC article. Review.
Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1. Ariana N Renrick, Menaka C Thounaojam, +4 authors, Anil Shanker. less Front Immunol, 2021 Mar 16; 12. PMID: 33717088 Free PMC article.
Recurrent Sepsis Exacerbates CD4+ T Cell Exhaustion and Decreases Antiviral Immune Responses. Wanxue He, Kun Xiao, +6 authors, Lixin Xie. less Front Immunol, 2021 Mar 16; 12. PMID: 33717146 Free PMC article.
Immunological Feature and Transcriptional Signaling of Ly6C Monocyte Subsets From Transcriptome Analysis in Control and Hyperhomocysteinemic Mice. Pingping Yang, Lu Liu, +9 authors, Hong Wang. less Front Immunol, 2021 Mar 16; 12. PMID: 33717169 Free PMC article.
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy. Shannon K Oda, Kristin G Anderson, +8 authors, Philip D Greenberg. less J Exp Med, 2020 Aug 30; 217(12). PMID: 32860705 Free PMC article.
Why do intestinal epithelial cells express MHC class II? Cornelia Heuberger, Johanna Pott, Kevin Joseph Maloy. Immunology, 2020 Sep 24; 162(4). PMID: 32966619 Free PMC article. Review.
Recent Advances in Costimulatory Blockade to Induce Immune Tolerance in Liver Transplantation. Mingjie Ding, Yuting He, Shuijun Zhang, Wenzhi Guo. Front Immunol, 2021 Mar 19; 12. PMID: 33732228 Free PMC article. Review.
Virus-specific T cells for malignancies - then, now and where to? Sandhya Sharma, Wingchi K Leung, Helen E Heslop. Curr Stem Cell Rep, 2021 Mar 20; 6(2). PMID: 33738181 Free PMC article.
Next generation of immune checkpoint inhibitors and beyond. Julian A Marin-Acevedo, ErinMarie O Kimbrough, Yanyan Lou. J Hematol Oncol, 2021 Mar 21; 14(1). PMID: 33741032 Free PMC article. Review.
Roles of the Dynamic Tumor Immune Microenvironment in the Individualized Treatment of Advanced Clear Cell Renal Cell Carcinoma. Enyu Lin, Xuechao Liu, +5 authors, Yuming Yu. less Front Immunol, 2021 Mar 23; 12. PMID: 33746989 Free PMC article. Review.
Tackling Immune Targets for Breast Cancer: Beyond PD-1/PD-L1 Axis. Yasser Tabana, Isobel S Okoye, +2 authors, Arno Siraki, Shokrollah Elahi, Khaled H Barakat. less Front Oncol, 2021 Mar 23; 11. PMID: 33747948 Free PMC article. Review.
Functional Characteristics and Phenotypic Plasticity of CD57+PD1- CD4 T Cells and Their Relationship with Transplant Immunosuppression. Brian I Shaw, Jaclyn R Espinosa, +3 authors, Allan D Kirk. less J Immunol, 2021 Feb 19; 206(7). PMID: 33597150 Free PMC article.
TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients. Jana Rakova, Iva Truxova, +12 authors, Jitka Fucikova. less Oncoimmunology, 2021 Mar 25; 10(1). PMID: 33758676 Free PMC article.
Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy. Iris Lodewijk, Sandra P Nunes, +3 authors, Jesús M Paramio. less Clin Epigenetics, 2021 Mar 26; 13(1). PMID: 33761971 Free PMC article. Review.
4-1BB costimulation promotes bystander activation of human CD8 T cells. Manuel Reithofer, Sandra Rosskopf, +4 authors, Beatrice Jahn-Schmid. less Eur J Immunol, 2020 Nov 13; 51(3). PMID: 33180337 Free PMC article.
Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer Patients. Claire Germain, Priyanka Devi-Marulkar, +16 authors, Marie-Caroline Dieu-Nosjean. less Front Immunol, 2021 Mar 26; 12. PMID: 33763071 Free PMC article.
Phenotypic and Functional Analyses Guiding Combination Immune Checkpoint Immunotherapeutic Strategies in HTLV-1 Infection. Danielle M Clements, Brenndan Crumley, +5 authors, Pooja Jain. less Front Immunol, 2021 Mar 27; 12. PMID: 33767694 Free PMC article.
Functional crosstalk between T cells and monocytes in cancer and atherosclerosis. Lindsey E Padgett, Daniel J Araujo, Catherine C Hedrick, Claire E Olingy. J Leukoc Biol, 2020 Jun 13; 108(1). PMID: 32531833 Free PMC article. Review.
Biomarkers in Immunotherapy-Based Precision Treatments of Digestive System Tumors. Zhu Zeng, Biao Yang, Zhengyin Liao. Front Oncol, 2021 Mar 30; 11. PMID: 33777812 Free PMC article. Review.
A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells. Zhaoqian Su, Kalyani Dhusia, Yinghao Wu. PLoS Comput Biol, 2021 Mar 09; 17(3). PMID: 33684103 Free PMC article.
LAG-3-Expressing Tumor-Infiltrating T Cells Are Associated with Reduced Disease-Free Survival in Pancreatic Cancer. Lena Seifert, Ioana Plesca, +9 authors, Adrian M Seifert. less Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33803936 Free PMC article.
Cell Surface Profiling of Retinal Müller Glial Cells Reveals Association to Immune Pathways after LPS Stimulation. Lea Lorenz, Sieglinde Hirmer, +2 authors, Adrian Schmalen, Stefanie M Hauck, Cornelia A Deeg. less Cells, 2021 Apr 04; 10(3). PMID: 33806940 Free PMC article.
Comprehensive genomic analysis identifying heterogeneity in peripheral T-cell lymphoma. Noriaki Yoshida, Kyohei Yamada, Koichi Ohshima. Cancer Sci, 2021 Feb 13; 112(4). PMID: 33576080 Free PMC article. Review.
Emerging Molecular Connections between NM23 Proteins, Telomeres and Telomere-Associated Factors: Implications in Cancer Metastasis and Ageing. Shalu Sharma, Antara Sengupta, Shantanu Chowdhury. Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33801585 Free PMC article. Review.
Engaging the Innate and Adaptive Antitumor Immune Response in Lymphoma. Clifford M Csizmar, Stephen M Ansell. Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33804869 Free PMC article. Review.
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention. Spencer C Wei, Wouter C Meijers, +24 authors, James P Allison. less Cancer Discov, 2020 Dec 02; 11(3). PMID: 33257470 Free PMC article.
Structural Basis of VSIG3: The Ligand for VISTA. Xiaoxue Xie, Caiping Chen, +5 authors, Jun Liu. less Front Immunol, 2021 Apr 13; 12. PMID: 33841409 Free PMC article.
Advances in immunotherapy for hepatocellular carcinoma. Bruno Sangro, Pablo Sarobe, Sandra Hervás-Stubbs, Ignacio Melero. Nat Rev Gastroenterol Hepatol, 2021 Apr 15; 18(8). PMID: 33850328 Free PMC article. Review.
MHC heterogeneity and response of metastases to immunotherapy. Ignacio Algarra, Federico Garrido, Angel M Garcia-Lora. Cancer Metastasis Rev, 2021 Apr 17; 40(2). PMID: 33860434 Review.
Novel approaches to enhance the specificity and safety of engineered T cells. Victor D Fedorov, Michel Sadelain, Christopher C Kloss. Cancer J, 2014 Mar 29; 20(2). PMID: 24667964 Free PMC article.
Default polyfunctional T helper 1 response to ample signal 1 alone. Luca Danelli, Georgina Cornish, Julia Merkenschlager, George Kassiotis. Cell Mol Immunol, 2020 Apr 22; 18(7). PMID: 32313208 Free PMC article.
Function and Role of Regulatory T Cells in Rheumatoid Arthritis. Qi Jiang, Guocan Yang, +2 authors, Qi Liu, Shengjun Wang, Dawei Cui. less Front Immunol, 2021 Apr 20; 12. PMID: 33868244 Free PMC article. Review.
Cellular networks controlling T cell persistence in adoptive cell therapy. Jack D Chan, Junyun Lai, +3 authors, Phillip K Darcy. less Nat Rev Immunol, 2021 Apr 22; 21(12). PMID: 33879873 Review.
CytoTalk: De novo construction of signal transduction networks using single-cell transcriptomic data. Yuxuan Hu, Tao Peng, Lin Gao, Kai Tan. Sci Adv, 2021 Apr 16; 7(16). PMID: 33853780 Free PMC article.
Inhibition of acid sphingomyelinase increases regulatory T cells in humans. Teresa Wiese, Fabio Dennstädt, +16 authors, Niklas Beyersdorf. less Brain Commun, 2021 Apr 27; 3(2). PMID: 33898989 Free PMC article.
Frontiers and Opportunities: Highlights of the 2nd Annual Conference of the Chinese Antibody Society. Hongyu Zhang, Mi Deng, +5 authors, Mitchell Ho. less Antib Ther, 2018 Nov 09; 1(2). PMID: 30406214 Free PMC article.
TIM-3 drives temporal differences in restimulation-induced cell death sensitivity in effector CD8+ T cells in conjunction with CEACAM1. Camille M Lake, Kelsey Voss, +4 authors, Andrew L Snow. less Cell Death Dis, 2021 Apr 16; 12(4). PMID: 33854046 Free PMC article.
Intersection of DNA Repair Pathways and the Immune Landscape Identifies PD-L2 as a Prognostic Marker in Epithelial Ovarian Cancer. Samantha Batman, Koji Matsuo, +8 authors, Tanja Pejovic. less Cancers (Basel), 2021 May 01; 13(8). PMID: 33923934 Free PMC article.
In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Sean Hammond, Paul Thomson, Xiaoli Meng, Dean Naisbitt. Front Immunol, 2021 May 01; 12. PMID: 33927714 Free PMC article. Review.
T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments. Naval Daver, Ahmad S Alotaibi, Veit Bücklein, Marion Subklewe. Leukemia, 2021 May 07; 35(7). PMID: 33953290 Free PMC article. Review.
Combination blockade of OX40L and CD30L inhibits allergen-driven memory TH2 cell reactivity and lung inflammation. Donald T Gracias, Gurupreet S Sethi, +4 authors, Michael Croft. less J Allergy Clin Immunol, 2020 Nov 09; 147(6). PMID: 33160971 Free PMC article.
Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic. Xuqing Zhang, Mengyao Luo, +19 authors, Tiffany F Chen. less Nat Commun, 2021 May 13; 12(1). PMID: 33976146 Free PMC article.
Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity. Yiwen Zhang, Hongrong Hu, +12 authors, Hui Zhang. less J Immunother Cancer, 2021 Apr 23; 9(4). PMID: 33883257 Free PMC article.
Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer. Anita K Mehta, Sapana Kadel, +2 authors, Madeline G Townsend, Madisson Oliwa, Jennifer L Guerriero. less Front Immunol, 2021 May 11; 12. PMID: 33968034 Free PMC article. Review.
Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1. Weimin Chen, Madhu Pandey, +7 authors, Shihua Lin. less MAbs, 2021 Apr 20; 13(1). PMID: 33870864 Free PMC article.
Insulin Signaling in Arthritis. Cesare Tripolino, Jacopo Ciaffi, +6 authors, Francesco Ursini. less Front Immunol, 2021 May 18; 12. PMID: 33995414 Free PMC article. Review.
Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity. Meihua Qiu, Yuqing Chen, Qiao Ye. BMC Pulm Med, 2021 May 24; 21(1). PMID: 34022844 Free PMC article.
Programmed cell death-1 single-nucleotide polymorphism rs10204525 is associated with human immunodeficiency virus type 1 RNA viral load in HIV-1-infected Moroccan subjects. Hanâ Baba, Anass Kettani, +10 authors, Lahcen Wakrim. less Med Microbiol Immunol, 2021 May 26; 210(4). PMID: 34031715
Glycosylation of Immune Receptors in Cancer. Ruoxuan Sun, Alyssa Min Jung Kim, Seung-Oe Lim. Cells, 2021 Jun 03; 10(5). PMID: 34064396 Free PMC article. Review.
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model. Shuyang S Qin, Booyeon J Han, +9 authors, Peter A Prieto. less Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34064795 Free PMC article.
CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection. Vuvi G Tran, Na N Z Nguyen, Byungsuk Kwon. J Fungi (Basel), 2021 Jun 03; 7(5). PMID: 34068963 Free PMC article.
Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control. Dafne C A Quixabeira, Sadia Zafar, +7 authors, Akseli Hemminki. less Front Immunol, 2021 Jun 05; 12. PMID: 34084172 Free PMC article.
B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling. Sadiye Amcaoglu Rieder, Jingya Wang, +6 authors, Roland Kolbeck. less Cell Mol Immunol, 2020 Feb 02; 18(6). PMID: 32005952 Free PMC article.
Immune checkpoints in targeted-immunotherapy of pancreatic cancer: New hope for clinical development. Seyed Hossein Kiaie, Mohammad Javad Sanaei, +5 authors, Behzad Baradaran. less Acta Pharm Sin B, 2021 Jun 08; 11(5). PMID: 34094821 Free PMC article. Review.
CAR T-cell therapy for pleural mesothelioma: Rationale, preclinical development, and clinical trials. Navin K Chintala, David Restle, +5 authors, Prasad S Adusumilli. less Lung Cancer, 2021 May 12; 157. PMID: 33972125 Free PMC article. Review.
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells. Zhiliang Bai, Stefan Lundh, +9 authors, Rong Fan. less J Immunother Cancer, 2021 May 20; 9(5). PMID: 34006631 Free PMC article.
Treg-Resistant Cytotoxic CD4+ T Cells Dictate T Helper Cells in Their Vicinity: TH17 Skewing and Modulation of Proliferation. Cindy Hoeks, Marjan Vanheusden, +3 authors, Niels Hellings. less Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34073458 Free PMC article.
Integrated analysis identifies S100A16 as a potential prognostic marker for pancreatic cancer. Tian Chen, De-Meng Xia, Chao Qian, Shan-Rong Liu. Am J Transl Res, 2021 Jun 22; 13(5). PMID: 34150181 Free PMC article.
Comprehensive landscape of immune-checkpoints uncovered in clear cell renal cell carcinoma reveals new and emerging therapeutic targets. Diana Tronik-Le Roux, Mathilde Sautreuil, +9 authors, Edgardo D Carosella. less Cancer Immunol Immunother, 2020 Mar 14; 69(7). PMID: 32166404
Determination of the molecular reach of the protein tyrosine phosphatase SHP-1. Lara Clemens, Mikhail Kutuzov, +3 authors, Omer Dushek. less Biophys J, 2021 Mar 31; 120(10). PMID: 33781765 Free PMC article.
Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes. Kin Man Au, Yusra Medik, +2 authors, Qi Ke, Roland Tisch, Andrew Z Wang. less Adv Mater, 2021 May 09; 33(25). PMID: 33963786 Free PMC article.
Immunological considerations and challenges for regenerative cellular therapies. Sandra Petrus-Reurer, Marco Romano, +3 authors, Kourosh Saeb-Parsy. less Commun Biol, 2021 Jun 27; 4(1). PMID: 34172826 Free PMC article. Review.
Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation. Sushila A Toulmin, Chaitali Bhadiadra, +6 authors, Laurence C Eisenlohr. less Nat Commun, 2021 Jun 30; 12(1). PMID: 34183650 Free PMC article.
Two Complementarity Immunotherapeutics in Non-Small-Cell Lung Cancer Patients-Mechanism of Action and Future Concepts. Kamila Wojas-Krawczyk, Paweł Krawczyk, Michał Gil, Maciej Strzemski. Cancers (Basel), 2021 Jul 03; 13(11). PMID: 34200219 Free PMC article. Review.
Strength and Numbers: The Role of Affinity and Avidity in the 'Quality' of T Cell Tolerance. Sébastien This, Stefanie F Valbon, Marie-Ève Lebel, Heather J Melichar. Cells, 2021 Jul 03; 10(6). PMID: 34204485 Free PMC article. Review.
Synergistic Activation of Bovine CD4+ T Cells by Neutrophils and IL-12. Zhengguo Xiao, Anmol Kandel, Lei Li. Pathogens, 2021 Jul 03; 10(6). PMID: 34204973 Free PMC article.
OX40L-OX40 Signaling in Atopic Dermatitis. Masutaka Furue, Mihoko Furue. J Clin Med, 2021 Jul 03; 10(12). PMID: 34208041

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