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doi: 10.1038/nri3405.

Molecular mechanisms of T cell co-stimulation and co-inhibition

Lieping Chen 1 Dallas B Flies  
  • PMID: 23470321
  •     134 References
  •     1062 citations


Co-stimulatory and co-inhibitory receptors have a pivotal role in T cell biology, as they determine the functional outcome of T cell receptor (TCR) signalling. The classic definition of T cell co-stimulation continues to evolve through the identification of new co-stimulatory and co-inhibitory receptors, the biochemical characterization of their downstream signalling events and the delineation of their immunological functions. Notably, it has been recently appreciated that co-stimulatory and co-inhibitory receptors display great diversity in expression, structure and function, and that their functions are largely context dependent. Here, we focus on some of these emerging concepts and review the mechanisms through which T cell activation, differentiation and function is controlled by co-stimulatory and co-inhibitory receptors.

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J Exp Med, 1991 Sep 01; 174(3). PMID: 1714933    Free PMC article.
Highly Cited.
Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer.
Christopher J Chan, Daniel M Andrews, Mark J Smyth.
Curr Opin Immunol, 2012 Jan 31; 24(2). PMID: 22285893
Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.
Coralie Bloch-Queyrat, Marie-Claude Fondanèche, +5 authors, Sylvain Latour.
J Exp Med, 2005 Jul 07; 202(1). PMID: 15998796    Free PMC article.
B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.
John R Sedy, Maya Gavrieli, +8 authors, Kenneth M Murphy.
Nat Immunol, 2004 Nov 30; 6(1). PMID: 15568026
Highly Cited.
The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo.
Alison M Paterson, Keturah E Brown, +7 authors, Arlene H Sharpe.
J Immunol, 2011 Jun 24; 187(3). PMID: 21697456    Free PMC article.
Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.
Lukas Baitsch, Amandine Legat, +11 authors, Daniel E Speiser.
PLoS One, 2012 Feb 22; 7(2). PMID: 22347406    Free PMC article.
Highly Cited.
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells.
Loise M Francisco, Victor H Salinas, +4 authors, Arlene H Sharpe.
J Exp Med, 2009 Dec 17; 206(13). PMID: 20008522    Free PMC article.
Highly Cited.
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.
Fang Zhao, Jennifer L Cannons, +2 authors, Pamela L Schwartzberg.
Immunity, 2012 Jun 12; 36(6). PMID: 22683123    Free PMC article.
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV.
Debora Franceschini, Marino Paroli, +6 authors, Vincenzo Barnaba.
J Clin Invest, 2009 Feb 21; 119(3). PMID: 19229109    Free PMC article.
Highly Cited.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom.
Science, 2011 Apr 09; 332(6029). PMID: 21474713    Free PMC article.
Highly Cited.
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.
Bertram Bengsch, Bianca Seigel, +5 authors, Robert Thimme.
PLoS Pathog, 2010 Jun 16; 6(6). PMID: 20548953    Free PMC article.
Highly Cited.
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
Shoba Amarnath, Carliann M Costanzo, +9 authors, Daniel H Fowler.
PLoS Biol, 2010 Feb 04; 8(2). PMID: 20126379    Free PMC article.
The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation.
Marcos W Steinberg, Timothy C Cheung, Carl F Ware.
Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017438    Free PMC article.
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Manu Rangachari, Chen Zhu, +13 authors, Vijay K Kuchroo.
Nat Med, 2012 Aug 07; 18(9). PMID: 22863785    Free PMC article.
Highly Cited.
Cell surface signaling molecules in the control of immune responses: a tide model.
Yuwen Zhu, Sheng Yao, Lieping Chen.
Immunity, 2011 Apr 23; 34(4). PMID: 21511182    Free PMC article.
HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation.
M L del Rio, C L Lucas, +2 authors, J I Rodriguez-Barbosa.
J Leukoc Biol, 2009 Dec 17; 87(2). PMID: 20007250
Transcription factor regulation of CD8+ T-cell memory and exhaustion.
Jill M Angelosanto, E John Wherry.
Immunol Rev, 2010 Jul 20; 236. PMID: 20636816
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta.
Kelly-Ann Sheppard, Lori J Fitz, +8 authors, Divya Chaudhary.
FEBS Lett, 2004 Sep 11; 574(1-3). PMID: 15358536
Highly Cited.
Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.
Jennifer L Cannons, Julie Z Wu, +6 authors, Pamela L Schwartzberg.
J Immunol, 2010 Jul 30; 185(5). PMID: 20668219    Free PMC article.
Host and microbial factors in regulation of T cells in the intestine.
Chang H Kim.
Front Immunol, 2013 Jun 19; 4. PMID: 23772228    Free PMC article.
Molecular insights for optimizing T cell receptor specificity against cancer.
Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer.
Front Immunol, 2013 Jun 27; 4. PMID: 23801991    Free PMC article.
A co-stimulatory trap set by myeloid leukemia cells.
Gunes Esendagli.
Oncoimmunology, 2013 Jul 31; 2(6). PMID: 23894714    Free PMC article.
CD70 is downregulated by interaction with CD27.
Mirela Kuka, Ivana Munitic, Maria Letizia Giardino Torchia, Jonathan D Ashwell.
J Immunol, 2013 Aug 06; 191(5). PMID: 23913967    Free PMC article.
The great balancing act: regulation and fate of antiviral T-cell interactions.
E Ashley Moseman, Dorian B McGavern.
Immunol Rev, 2013 Aug 21; 255(1). PMID: 23947351    Free PMC article.
Antigen and transforming growth factor Beta receptors contribute to long term functional and phenotypic heterogeneity of memory CD8 T cells.
Yinghong Hu, Linda Cauley.
Front Immunol, 2013 Aug 22; 4. PMID: 23964275    Free PMC article.
Paramyxovirus activation and inhibition of innate immune responses.
Griffith D Parks, Martha A Alexander-Miller.
J Mol Biol, 2013 Sep 24; 425(24). PMID: 24056173    Free PMC article.
SOCS3 deletion in T lymphocytes suppresses development of chronic ocular inflammation via upregulation of CTLA-4 and expansion of regulatory T cells.
Cheng-Rong Yu, Sung-Hye Kim, Rashid M Mahdi, Charles E Egwuagu.
J Immunol, 2013 Oct 09; 191(10). PMID: 24101549    Free PMC article.
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy.
Paula D Bos, George Plitas, +2 authors, Alexander Y Rudensky.
J Exp Med, 2013 Oct 16; 210(11). PMID: 24127486    Free PMC article.
Highly Cited.
Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics.
Sachin Gupta, James M Termini, Saravana Kanagavelu, Geoffrey W Stone.
Immunol Res, 2013 Nov 08; 57(1-3). PMID: 24198065    Free PMC article.
Emerging Co-signaling Networks in T Cell Immune Regulation.
Keunok Jung, Inhak Choi.
Immune Netw, 2013 Nov 08; 13(5). PMID: 24198743    Free PMC article.
Induction and stability of the anergic phenotype in T cells.
Rut Valdor, Fernando Macian.
Semin Immunol, 2013 Nov 12; 25(4). PMID: 24211041    Free PMC article.
Allogeneic T cell responses are regulated by a specific miRNA-mRNA network.
Yaping Sun, Isao Tawara, +7 authors, Pavan Reddy.
J Clin Invest, 2013 Nov 13; 123(11). PMID: 24216511    Free PMC article.
Expanding role of T cells in acute kidney injury.
Gilbert R Kinsey, Mark D Okusa.
Curr Opin Nephrol Hypertens, 2013 Nov 16; 23(1). PMID: 24231312    Free PMC article.
TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu.
Andre Kunert, Trudy Straetemans, +4 authors, Reno Debets.
Front Immunol, 2013 Nov 23; 4. PMID: 24265631    Free PMC article.
Design and development of therapies using chimeric antigen receptor-expressing T cells.
Gianpietro Dotti, Stephen Gottschalk, Barbara Savoldo, Malcolm K Brenner.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329793    Free PMC article.
Highly Cited. Review.
Current advances in immunotherapy for pancreatic cancer.
Jennifer N Uram, Dung T Le.
Curr Probl Cancer, 2013 Dec 18; 37(5). PMID: 24331182    Free PMC article.
T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases.
Kiera L Clayton, Matthew S Haaland, +4 authors, Mario A Ostrowski.
J Immunol, 2013 Dec 18; 192(2). PMID: 24337741    Free PMC article.
Prospects for therapeutic tolerance in humans.
Kenneth F Baker, John D Isaacs.
Curr Opin Rheumatol, 2014 Jan 01; 26(2). PMID: 24378931    Free PMC article.
Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells.
Amandine Legat, Daniel E Speiser, +2 authors, Silvia A Fuertes Marraco.
Front Immunol, 2014 Jan 07; 4. PMID: 24391639    Free PMC article.
Highly Cited.
Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly.
Aurélie Le Page, Carl Fortin, +6 authors, Tamas Fülöp.
Cell Commun Signal, 2014 Jan 11; 12. PMID: 24405902    Free PMC article.
Hunting complex differential gene interaction patterns across molecular contexts.
Mingzhou Song, Yang Zhang, +2 authors, Laura Buttitta.
Nucleic Acids Res, 2014 Feb 01; 42(7). PMID: 24482443    Free PMC article.
The new normal: immunomodulatory agents against sepsis immune suppression.
Noelle A Hutchins, Jacqueline Unsinger, Richard S Hotchkiss, Alfred Ayala.
Trends Mol Med, 2014 Feb 04; 20(4). PMID: 24485901    Free PMC article.
Highly Cited. Review.
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
Scott M Reba, Qing Li, +10 authors, Roxana E Rojas.
Eur J Immunol, 2014 Feb 06; 44(5). PMID: 24497180    Free PMC article.
Stochastic modelling of T-cell activation.
Hannah Mayer, Anton Bovier.
J Math Biol, 2014 Feb 07; 70(1-2). PMID: 24500058
Diverse macrophage populations mediate acute lung inflammation and resolution.
Neil R Aggarwal, Landon S King, Franco R D'Alessio.
Am J Physiol Lung Cell Mol Physiol, 2014 Feb 11; 306(8). PMID: 24508730    Free PMC article.
Highly Cited. Review.
SA-4-1BBL as a novel adjuvant for the development of therapeutic cancer vaccines.
Rajesh K Sharma, Esma S Yolcu, Haval Shirwan.
Expert Rev Vaccines, 2014 Feb 14; 13(3). PMID: 24521311    Free PMC article.
Cutaneous T cell lymphoma expresses immunosuppressive CD80 (B7-1) cell surface protein in a STAT5-dependent manner.
Qian Zhang, Hong Yi Wang, +11 authors, Mariusz A Wasik.
J Immunol, 2014 Feb 14; 192(6). PMID: 24523507    Free PMC article.
Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection.
Jacob V Gorman, Gabriel Starbeck-Miller, +4 authors, John D Colgan.
J Immunol, 2014 Feb 26; 192(7). PMID: 24567532    Free PMC article.
Infection biology: Nibbled to death.
Nancy Guillén.
Nature, 2014 Apr 11; 508(7497). PMID: 24717438
Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis.
Kang-kang Liu, Qing-tong Wang, +3 authors, Wei Wei.
Acta Pharmacol Sin, 2014 Apr 15; 35(5). PMID: 24727939    Free PMC article.
Allergic sensitization: host-immune factors.
Ronald van Ree, Lone Hummelshøj, +2 authors, Emily Swindle.
Clin Transl Allergy, 2014 Apr 17; 4(1). PMID: 24735802    Free PMC article.
Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity.
Dallas B Flies, Xue Han, +4 authors, Lieping Chen.
J Clin Invest, 2014 Apr 20; 124(5). PMID: 24743150    Free PMC article.
Highly Cited.
Abatacept (cytotoxic T lymphocyte antigen 4-immunoglobulin) improves B cell function and regulatory T cell inhibitory capacity in rheumatoid arthritis patients non-responding to anti-tumour necrosis factor-α agents.
A Picchianti Diamanti, M M Rosado, +6 authors, R Carsetti.
Clin Exp Immunol, 2014 Apr 30; 177(3). PMID: 24773026    Free PMC article.
Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells.
Sachiko Hirosue, Efthymia Vokali, +7 authors, Melody A Swartz.
J Immunol, 2014 May 06; 192(11). PMID: 24795456    Free PMC article.
Highly Cited.
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
Christian A Bauer, Edward Y Kim, +3 authors, Thorsten R Mempel.
J Clin Invest, 2014 May 09; 124(6). PMID: 24812664    Free PMC article.
Highly Cited.
Monocyte-activation phenotypes are associated with biomarkers of inflammation and coagulation in chronic HIV infection.
Eleanor M P Wilson, Amrit Singh, +10 authors, Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study) Investigators.
J Infect Dis, 2014 May 13; 210(9). PMID: 24813472    Free PMC article.
Initiation of an inflammatory response in resident intestinal lamina propria cells -use of a human organ culture model.
Jutta Schröder-Braunstein, Judith Gras, +15 authors, Stefan Meuer.
PLoS One, 2014 May 21; 9(5). PMID: 24841635    Free PMC article.
What have we learned from cancer immunotherapy in the last 3 years?
Paolo A Ascierto, Francesco M Marincola.
J Transl Med, 2014 Jun 03; 12. PMID: 24886164    Free PMC article.
The development of endometrial hyperplasia in aged PD-1-deficient female mice.
Guoning Guo, Hong Li, Dayan Cao, Yongwen Chen.
Diagn Pathol, 2014 Jun 03; 9. PMID: 24886298    Free PMC article.
Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions.
Tai Hato, Lipika Goyal, +2 authors, Andrew X Zhu.
Hepatology, 2014 Jun 11; 60(5). PMID: 24912948    Free PMC article.
Highly Cited. Review.
The "Trojan Horse" approach to tumor immunotherapy: targeting the tumor microenvironment.
Delia Nelson, Scott Fisher, Bruce Robinson.
J Immunol Res, 2014 Jun 24; 2014. PMID: 24955376    Free PMC article.
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses.
Kristen N Pollizzi, Jonathan D Powell.
Nat Rev Immunol, 2014 Jun 26; 14(7). PMID: 24962260    Free PMC article.
Highly Cited. Review.
Induction of death receptor CD95 and co-stimulatory molecules CD80 and CD86 by meningococcal capsular polysaccharide-loaded vaccine nanoparticles.
Ruhi V Ubale, Rikhav P Gala, Susu M Zughaier, Martin J D'Souza.
AAPS J, 2014 Jul 02; 16(5). PMID: 24981893    Free PMC article.
TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells.
Ellen J Beswick, Jameel R Johnson, +8 authors, Irina V Pinchuk.
J Immunol, 2014 Jul 30; 193(5). PMID: 25070848    Free PMC article.
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.
KiBem Kim, Andrew D Skora, +8 authors, Shibin Zhou.
Proc Natl Acad Sci U S A, 2014 Jul 30; 111(32). PMID: 25071169    Free PMC article.
Highly Cited.
Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.
Yilin Cao, Jeffrey C Rathmell, Andrew N Macintyre.
PLoS One, 2014 Aug 05; 9(8). PMID: 25090630    Free PMC article.
Integrative biology of T cell activation.
Bernard Malissen, Claude Grégoire, Marie Malissen, Romain Roncagalli.
Nat Immunol, 2014 Aug 20; 15(9). PMID: 25137453
In situ characterization of intrahepatic non-parenchymal cells in PSC reveals phenotypic patterns associated with disease severity.
Lena Berglin, Annika Bergquist, +6 authors, Niklas K Björkström.
PLoS One, 2014 Aug 21; 9(8). PMID: 25141347    Free PMC article.
Changing faces in virology: the dutch shift from oncogenic to oncolytic viruses.
Zineb Belcaid, Martine L M Lamfers, Victor W van Beusechem, Rob C Hoeben.
Hum Gene Ther, 2014 Aug 22; 25(10). PMID: 25141764    Free PMC article.
Peptides and peptidomimetics as immunomodulators.
Ameya S Gokhale, Seetharama Satyanarayanajois.
Immunotherapy, 2014 Sep 05; 6(6). PMID: 25186605    Free PMC article.
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
Hye Sun Kuehn, Weiming Ouyang, +33 authors, Gulbu Uzel.
Science, 2014 Sep 13; 345(6204). PMID: 25213377    Free PMC article.
Highly Cited.
Associations between the cytotoxic T lymphocyte antigen 4 polymorphisms and risk of bone sarcomas.
Changchun Fan, Xuechun Zhao, Zhixing Xu.
Tumour Biol, 2014 Sep 19; 36(1). PMID: 25230787
CD4+ T cells promote the pathogenesis of Staphylococcus aureus pneumonia.
Dane Parker, Chanelle L Ryan, +3 authors, Alice S Prince.
J Infect Dis, 2014 Sep 23; 211(5). PMID: 25240171    Free PMC article.
Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.
Kenneth H Ely, Mitsuo Matsuoka, +6 authors, Richard I Enelow.
PLoS One, 2014 Sep 25; 9(9). PMID: 25251060    Free PMC article.
T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?
Daniel E Speiser, Daniel T Utzschneider, +3 authors, Dietmar Zehn.
Nat Rev Immunol, 2014 Sep 27; 14(11). PMID: 25257362
Highly Cited.
From bench to bedside: immunotherapy for prostate cancer.
Brian Wan-Chi Tse, Lidija Jovanovic, +3 authors, Pamela Joan Russell.
Biomed Res Int, 2014 Oct 03; 2014. PMID: 25276838    Free PMC article.
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.
Toshiyuki Yoshida, Takanori Iwata, +3 authors, Teruo Okano.
Genes Cells, 2014 Oct 10; 19(11). PMID: 25297509    Free PMC article.
T cell-macrophage interactions and granuloma formation in vasculitis.
Marc Hilhorst, Tsuyoshi Shirai, +2 authors, Cornelia M Weyand.
Front Immunol, 2014 Oct 14; 5. PMID: 25309534    Free PMC article.
Bone Marrow Mesenchymal Stromal Cells Induce Proliferative, Cytokinic and Molecular Changes During the T Cell Response: The Importance of the IL-10/CD210 Axis.
Mehdi Najar, Gordana Raicevic, +4 authors, Laurence Lagneaux.
Stem Cell Rev Rep, 2014 Oct 19; 11(3). PMID: 25326368
[Advances of PD-1/PD-L1 signaling pathway in immune escape and treatment for 
non-small cell lung cancer].
Cheng Lin, Xiong Chen, +2 authors, Xuenong Ou-Yang.
Zhongguo Fei Ai Za Zhi, 2014 Oct 25; 17(10). PMID: 25342040    Free PMC article.
Transplantation: molecular phenotyping of T-cell-mediated rejection.
Anita S Chong, David L Perkins.
Nat Rev Nephrol, 2014 Oct 29; 10(12). PMID: 25347945    Free PMC article.
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Limo Chen, Don L Gibbons, +27 authors, F Xiao-Feng Qin.
Nat Commun, 2014 Oct 29; 5. PMID: 25348003    Free PMC article.
Highly Cited.
Liposomes as vaccine delivery systems: a review of the recent advances.
Reto A Schwendener.
Ther Adv Vaccines, 2014 Nov 05; 2(6). PMID: 25364509    Free PMC article.
Highly Cited. Review.
Cognate CD4 T-cell licensing of dendritic cells heralds anti-cytomegalovirus CD8 T-cell immunity after human allogeneic umbilical cord blood transplantation.
T W H Flinsenberg, L Spel, +11 authors, M Boes.
J Virol, 2014 Nov 08; 89(2). PMID: 25378489    Free PMC article.
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Sarah Buchan, Teresa Manzo, +12 authors, Ronjon Chakraverty.
J Immunol, 2014 Nov 19; 194(1). PMID: 25404365    Free PMC article.
Soluble co-signaling molecules predict long-term graft outcome in kidney-transplanted patients.
Susana G Melendreras, Pablo Martínez-Camblor, +7 authors, Beatriz Suárez-Álvarez.
PLoS One, 2014 Dec 06; 9(12). PMID: 25478957    Free PMC article.
B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease.
Ruishu Deng, Kaniel Cassady, +6 authors, Defu Zeng.
J Immunol, 2014 Dec 10; 194(2). PMID: 25488990    Free PMC article.
Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex®.
Anne-Kristin Heninger, Sabine Wentrup, +5 authors, Jutta Schröder-Braunstein.
Immun Inflamm Dis, 2014 Dec 17; 2(3). PMID: 25505551    Free PMC article.
Current advances in T-cell-based cancer immunotherapy.
Mingjun Wang, Bingnan Yin, Helen Y Wang, Rong-Fu Wang.
Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524383    Free PMC article.
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.
Robby Markwart, Stephanie A Condotta, +9 authors, Ignacio Rubio.
PLoS One, 2014 Dec 30; 9(12). PMID: 25541945    Free PMC article.
New insights into T-cell cosignaling in allograft rejection and survival.
Scott M Krummey, Mandy L Ford.
Curr Opin Organ Transplant, 2015 Jan 08; 20(1). PMID: 25563991    Free PMC article.
The aptamer-siRNA conjugates: reprogramming T cells for cancer therapy.
Dewan Md Sakib Hossain, Priyanka Duttagupta, Marcin Kortylewski.
Ther Deliv, 2015 Jan 08; 6(1). PMID: 25565435    Free PMC article.
Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study.
Daniel J Merenstein, Tina P Tan, +6 authors, Gloria Solano-Aguilar.
Gut Microbes, 2015 Jan 09; 6(1). PMID: 25569274    Free PMC article.
Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.
Karen Laky, Sharron Evans, Ainhoa Perez-Diez, B J Fowlkes.
Immunity, 2015 Jan 22; 42(1). PMID: 25607460    Free PMC article.
T cell exhaustion during persistent viral infections.
Shannon M Kahan, E John Wherry, Allan J Zajac.
Virology, 2015 Jan 27; 479-480. PMID: 25620767    Free PMC article.
Highly Cited. Review.
Novel roles of c-Met in the survival of renal cancer cells through the regulation of HO-1 and PD-L1 expression.
Murugabaskar Balan, Eduardo Mier y Teran, +4 authors, Soumitro Pal.
J Biol Chem, 2015 Feb 04; 290(13). PMID: 25645920    Free PMC article.
Renal C3 complement component: feed forward to diabetic kidney disease.
Katherine J Kelly, Yunlong Liu, Jizhong Zhang, Jesus H Dominguez.
Am J Nephrol, 2015 Feb 11; 41(1). PMID: 25662584    Free PMC article.
TNF superfamily protein-protein interactions: feasibility of small- molecule modulation.
Yun Song, Peter Buchwald.
Curr Drug Targets, 2015 Feb 24; 16(4). PMID: 25706111    Free PMC article.
In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.
Stéphanie O Morin, Valentin Giroux, +7 authors, Jacques A Nunès.
Cell Mol Life Sci, 2015 Mar 03; 72(14). PMID: 25725801    Free PMC article.
Immunoregulatory molecules in patients with gestational diabetes mellitus.
Karen Priscilla Tezotto Pendeloski, Rosiane Mattar, +3 authors, Silvia Daher.
Endocrine, 2015 Mar 11; 50(1). PMID: 25754913
ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection.
Clare L Marriott, Gianluca Carlesso, Ronald Herbst, David R Withers.
Eur J Immunol, 2015 Mar 11; 45(6). PMID: 25754933    Free PMC article.
OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal.
Stefanie N Linch, Michael J McNamara, William L Redmond.
Front Oncol, 2015 Mar 13; 5. PMID: 25763356    Free PMC article.
Highly Cited. Review.
Characterization of PD-L1 Expression and Associated T-cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites.
Harriet M Kluger, Christopher R Zito, +6 authors, Lucia B Jilaveanu.
Clin Cancer Res, 2015 Mar 20; 21(13). PMID: 25788491    Free PMC article.
Highly Cited.
T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance.
B Ye, X Liu, +3 authors, Y Chen.
Cell Death Dis, 2015 Mar 20; 6. PMID: 25789969    Free PMC article.
Highly Cited. Review.
TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity.
Degui Geng, Sabina Kaczanowska, +5 authors, Eduardo Davila.
Cancer Res, 2015 Mar 22; 75(10). PMID: 25795705    Free PMC article.
The importance of co-stimulation in the orchestration of T helper cell differentiation.
Jonathan M Coquet, Lisa Rausch, Jannie Borst.
Immunol Cell Biol, 2015 Mar 25; 93(9). PMID: 25801480
New cell sources for T cell engineering and adoptive immunotherapy.
Maria Themeli, Isabelle Rivière, Michel Sadelain.
Cell Stem Cell, 2015 Apr 07; 16(4). PMID: 25842976    Free PMC article.
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy.
Mihaela Angelova, Pornpimol Charoentong, +8 authors, Zlatko Trajanoski.
Genome Biol, 2015 Apr 09; 16. PMID: 25853550    Free PMC article.
Highly Cited.
Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig.
Yrina Rochman, Masashi Yukawa, Andrey V Kartashov, Artem Barski.
PLoS One, 2015 Apr 11; 10(4). PMID: 25860138    Free PMC article.
Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells.
Ewa Kozela, Ana Juknat, +3 authors, Zvi Vogel.
J Neuroinflammation, 2015 Apr 17; 12. PMID: 25880134    Free PMC article.
PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity.
Ryan A Zander, Nyamekye Obeng-Adjei, +6 authors, Noah S Butler.
Cell Host Microbe, 2015 Apr 22; 17(5). PMID: 25891357    Free PMC article.
Boosting Cancer Immunotherapy with Anti-CD137 Antibody Therapy.
Atsushi Yonezawa, Suparna Dutt, +2 authors, Holbrook E Kohrt.
Clin Cancer Res, 2015 Apr 25; 21(14). PMID: 25908780    Free PMC article.
Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens.
Dallas B Flies, Tomoe Higuchi, Lieping Chen.
J Immunol, 2015 Apr 29; 194(11). PMID: 25917101    Free PMC article.
NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma.
Takumi Kobayashi, Brianna L Doff, +2 authors, Stephen R Mattarollo.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949907    Free PMC article.
Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications.
Marta E Castro-Manrreza, Juan J Montesinos.
J Immunol Res, 2015 May 12; 2015. PMID: 25961059    Free PMC article.
Highly Cited. Review.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Jun Liu, Ying Yuan, +8 authors, Li Wang.
Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334    Free PMC article.
Highly Cited.
Programmed death-1 controls T cell survival by regulating oxidative metabolism.
Victor Tkachev, Stefanie Goodell, +5 authors, Craig A Byersdorfer.
J Immunol, 2015 May 15; 194(12). PMID: 25972478    Free PMC article.
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy.
Keishi Adachi, Koji Tamada.
Cancer Sci, 2015 May 20; 106(8). PMID: 25981182    Free PMC article.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Beyond adjuvants: immunomodulation strategies to enhance T cell immunity.
Alice O Kamphorst, Koichi Araki, Rafi Ahmed.
Vaccine, 2015 May 30; 33 Suppl 2. PMID: 26022562    Free PMC article.
B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets.
Liqun Luo, Gefeng Zhu, +12 authors, Lieping Chen.
PLoS One, 2015 Jun 13; 10(6). PMID: 26065426    Free PMC article.
Charting Immune Signaling Proteomes En Route to New Therapeutic Strategies.
Eric B Haura, Amer A Beg, Uwe Rix, Scott Antonia.
Cancer Immunol Res, 2015 Jun 18; 3(7). PMID: 26081226    Free PMC article.
Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.
Danya Liu, Suzanne J Suchard, Steve G Nadler, Mandy L Ford.
PLoS One, 2015 Jun 23; 10(6). PMID: 26098894    Free PMC article.
PD-L1 and Survival in Solid Tumors: A Meta-Analysis.
Pin Wu, Dang Wu, +2 authors, Jian Huang.
PLoS One, 2015 Jun 27; 10(6). PMID: 26114883    Free PMC article.
Highly Cited. Systematic Review.
The pharmacology of second-generation chimeric antigen receptors.
Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain.
Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802    Free PMC article.
Highly Cited. Review.
Regulatory T cells and minimal change nephropathy: in the midst of a complex network.
R Bertelli, A Bonanni, +3 authors, G M Ghiggeri.
Clin Exp Immunol, 2015 Jul 07; 183(2). PMID: 26147676    Free PMC article.
Clinical Development of Immune Checkpoint Inhibitors.
Ayumu Ito, Shunsuke Kondo, Kohei Tada, Shigehisa Kitano.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161407    Free PMC article.
Inhibitory Receptors Beyond T Cell Exhaustion.
Silvia A Fuertes Marraco, Natalie J Neubert, Grégory Verdeil, Daniel E Speiser.
Front Immunol, 2015 Jul 15; 6. PMID: 26167163    Free PMC article.
Highly Cited. Review.
Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation.
Bala Sai Sundarasetty, Stephan Kloess, +14 authors, Renata Stripecke.
J Transl Med, 2015 Jul 23; 13. PMID: 26198406    Free PMC article.
HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications.
Zaruhi Karabekian, Hao Ding, +9 authors, Narine Sarvazyan.
Tissue Eng Part A, 2015 Jul 29; 21(19-20). PMID: 26218149    Free PMC article.
Combination cancer immunotherapy and new immunomodulatory targets.
Kathleen M Mahoney, Paul D Rennert, Gordon J Freeman.
Nat Rev Drug Discov, 2015 Aug 01; 14(8). PMID: 26228759
Highly Cited. Review.
Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.
C Krupka, P Kufer, +14 authors, M Subklewe.
Leukemia, 2015 Aug 05; 30(2). PMID: 26239198
Highly Cited.
IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice.
Rafael R Flores, Eun Kim, +4 authors, Paul D Robbins.
Eur J Immunol, 2015 Aug 12; 45(11). PMID: 26260044    Free PMC article.
1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept.
David H Gardner, Louisa E Jeffery, +4 authors, David M Sansom.
J Immunol, 2015 Aug 16; 195(6). PMID: 26276872    Free PMC article.
The Role of PKC-θ in CD4+ T Cells and HIV Infection: To the Nucleus and Back Again.
Chansavath Phetsouphanh, Anthony D Kelleher.
Front Immunol, 2015 Aug 19; 6. PMID: 26284074    Free PMC article.
T-cell ligands modulate the cytolytic activity of the CD33/CD3 BiTE antibody construct, AMG 330.
G S Laszlo, C J Gudgeon, K H Harrington, R B Walter.
Blood Cancer J, 2015 Aug 22; 5. PMID: 26295610    Free PMC article.
Perspectives in the treatment of pancreatic adenocarcinoma.
Angel Cid-Arregui, Victoria Juarez.
World J Gastroenterol, 2015 Aug 27; 21(31). PMID: 26309356    Free PMC article.
Novel Immune Check-Point Regulators in Tolerance Maintenance.
Yanxia Guo, Adele Y Wang.
Front Immunol, 2015 Sep 09; 6. PMID: 26347744    Free PMC article.
CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection.
R A Drummond, I M Dambuza, +7 authors, G D Brown.
Mucosal Immunol, 2015 Sep 10; 9(2). PMID: 26349660    Free PMC article.
Transient Loss of Protection Afforded by a Live Attenuated Non-typhoidal Salmonella Vaccine in Mice Co-infected with Malaria.
Jason P Mooney, Seung-Joo Lee, +4 authors, Renée M Tsolis.
PLoS Negl Trop Dis, 2015 Sep 15; 9(9). PMID: 26366739    Free PMC article.
Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysis.
Tengfei Zhang, Ling Cao, +10 authors, Yi Zhang.
Oncotarget, 2015 Sep 18; 6(32). PMID: 26376680    Free PMC article.
Clinical significance of tumor-infiltrating immune cells focusing on BTLA and Cbl-b in patients with gallbladder cancer.
Seiji Oguro, Yoshinori Ino, +7 authors, Nobuyoshi Hiraoka.
Cancer Sci, 2015 Sep 24; 106(12). PMID: 26395180    Free PMC article.
Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody.
L Xue, T Hickling, +2 authors, B Rup.
Clin Exp Immunol, 2015 Sep 25; 183(1). PMID: 26400440    Free PMC article.
Nivolumab in combination with ipilimumab for the treatment of melanoma.
Rajasekharan Somasundaram, Meenhard Herlyn.
Expert Rev Anticancer Ther, 2015 Sep 25; 15(10). PMID: 26402246    Free PMC article.
A three-signal model of T-cell lymphoma pathogenesis.
Ryan A Wilcox.
Am J Hematol, 2015 Sep 27; 91(1). PMID: 26408334    Free PMC article.
Biomarkers for Sepsis: What Is and What Might Be?
Bethany M Biron, Alfred Ayala, Joanne L Lomas-Neira.
Biomark Insights, 2015 Sep 30; 10(Suppl 4). PMID: 26417200    Free PMC article.
Potentiality of immunotherapy against hepatocellular carcinoma.
Nobuhiro Tsuchiya, Yu Sawada, +2 authors, Tetsuya Nakatsura.
World J Gastroenterol, 2015 Oct 01; 21(36). PMID: 26420958    Free PMC article.
Integrated molecular analysis of adult T cell leukemia/lymphoma.
Keisuke Kataoka, Yasunobu Nagata, +56 authors, Seishi Ogawa.
Nat Genet, 2015 Oct 06; 47(11). PMID: 26437031
Highly Cited.
Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells.
Dongmei Fan, Wei Li, +6 authors, Dongsheng Xiong.
J Hematol Oncol, 2015 Oct 09; 8. PMID: 26444983    Free PMC article.
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.
Zeguo Zhao, Maud Condomines, +5 authors, Michel Sadelain.
Cancer Cell, 2015 Oct 16; 28(4). PMID: 26461090    Free PMC article.
Highly Cited.
Comparing the Primary and Recall Immune Response Induced by a New EV71 Vaccine Using Systems Biology Approaches.
Jie Shao, Junnan Zhang, +7 authors, Junzhi Wang.
PLoS One, 2015 Oct 16; 10(10). PMID: 26465882    Free PMC article.
High intensity focused ultrasound enhances anti-tumor immunity by inhibiting the negative regulatory effect of miR-134 on CD86 in a murine melanoma model.
Shi-Mei Yuan, Huan Li, +12 authors, Lan Zhou.
Oncotarget, 2015 Oct 21; 6(35). PMID: 26485753    Free PMC article.
Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab.
Venky Ramakrishna, Karuna Sundarapandiyan, +3 authors, Tibor Keler.
J Immunother Cancer, 2015 Oct 27; 3. PMID: 26500773    Free PMC article.
Current Treatment, Emerging Translational Therapies, and New Therapeutic Targets for Autoimmune Myasthenia Gravis.
Jeffrey T Guptill, Madhu Soni, Matthew N Meriggioli.
Neurotherapeutics, 2015 Oct 30; 13(1). PMID: 26510558    Free PMC article.
The role of lymphocytes in the development and treatment of alopecia areata.
Hongwei Guo, Yabin Cheng, Jerry Shapiro, Kevin McElwee.
Expert Rev Clin Immunol, 2015 Nov 10; 11(12). PMID: 26548356    Free PMC article.
Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer.
Joseph McLaughlin, Gang Han, +7 authors, David L Rimm.
JAMA Oncol, 2015 Nov 13; 2(1). PMID: 26562159    Free PMC article.
Highly Cited.
Temporal protein expression pattern in intracellular signalling cascade during T-cell activation: a computational study.
Piyali Ganguli, Saikat Chowdhury, Rupa Bhowmick, Ram Rup Sarkar.
J Biosci, 2015 Nov 14; 40(4). PMID: 26564978
Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy.
Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong.
J Immunol Res, 2015 Nov 19; 2015. PMID: 26579545    Free PMC article.
FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression.
Anil K Chauhan, Terry L Moore, Ye Bi, Chen Chen.
J Biol Chem, 2015 Nov 20; 291(3). PMID: 26582197    Free PMC article.
Are Microglial Cells the Regulators of Lymphocyte Responses in the CNS?
Beatriz Almolda, Berta González, Bernardo Castellano.
Front Cell Neurosci, 2015 Dec 05; 9. PMID: 26635525    Free PMC article.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy.
Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake.
Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632    Free PMC article.
Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen.
R D Fannin, K Gerrish, +3 authors, R S Paules.
Clin Pharmacol Ther, 2015 Dec 23; 99(4). PMID: 26690555    Free PMC article.
Sepsis-induced immune dysfunction: can immune therapies reduce mortality?
Matthew J Delano, Peter A Ward.
J Clin Invest, 2016 Jan 05; 126(1). PMID: 26727230    Free PMC article.
Highly Cited. Review.
HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).
Keiko Yasuma, Jun-ichirou Yasunaga, +6 authors, Masao Matsuoka.
PLoS Pathog, 2016 Jan 07; 12(1). PMID: 26735971    Free PMC article.
Identification of CD112R as a novel checkpoint for human T cells.
Yuwen Zhu, Alessandro Paniccia, +6 authors, Barish H Edil.
J Exp Med, 2016 Jan 13; 213(2). PMID: 26755705    Free PMC article.
Roles of PD-1, Tim-3 and CTLA-4 in immunoregulation in regulatory T cells among patients with sepsis.
Dong-Na Gao, Zhi-Xiang Yang, Qing-Hui Qi.
Int J Clin Exp Med, 2016 Jan 16; 8(10). PMID: 26770525    Free PMC article.
Immunotherapy: New Strategies for the Treatment of Gynecologic Malignancies.
Ariel Bulua Bourla, Dmitriy Zamarin.
Oncology (Williston Park), 2016 Jan 23; 30(1). PMID: 26791846    Free PMC article.
Impact of host genetic polymorphisms on vaccine induced antibody response.
Janina E Linnik, Adrian Egli.
Hum Vaccin Immunother, 2016 Jan 27; 12(4). PMID: 26809773    Free PMC article.
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.
Kole T Roybal, Levi J Rupp, +4 authors, Wendell A Lim.
Cell, 2016 Feb 03; 164(4). PMID: 26830879    Free PMC article.
Highly Cited.
Generating Peripheral Blood Derived Lymphocytes Reacting Against Autologous Primary AML Blasts.
Rohtesh S Mehta, Xiaohua Chen, +2 authors, Paul Szabolcs.
J Immunother, 2016 Feb 06; 39(2). PMID: 26849076    Free PMC article.
Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction.
Anna Lissina, David R Ambrozak, +12 authors, Victor Appay.
Immunol Cell Biol, 2016 Feb 11; 94(6). PMID: 26860368
Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma.
Dai Liu, Kevin F Staveley-O'Carroll, Guangfu Li.
J Clin Cell Immunol, 2016 Feb 16; 6(6). PMID: 26877890    Free PMC article.
Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse.
Claire Hivroz, Michael Saitakis.
Front Immunol, 2016 Feb 26; 7. PMID: 26913033    Free PMC article.
Memory T cells in organ transplantation: progress and challenges.
Jaclyn R Espinosa, Kannan P Samy, Allan D Kirk.
Nat Rev Nephrol, 2016 Mar 01; 12(6). PMID: 26923209    Free PMC article.
Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities.
K M Morrissey, T M Yuraszeck, +2 authors, S Kasichayanula.
Clin Transl Sci, 2016 Mar 01; 9(2). PMID: 26924066    Free PMC article.
Highly Cited. Review.
Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism.
Sara Labiano, Asis Palazón, +11 authors, Ignacio Melero.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942078    Free PMC article.
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging.
Liang Han, Derek K Kong, +16 authors, Jiangbing Zhou.
ACS Nano, 2016 Mar 12; 10(4). PMID: 26967254    Free PMC article.
T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells.
James M Conley, Michael P Gallagher, Leslie J Berg.
Front Immunol, 2016 Mar 15; 7. PMID: 26973653    Free PMC article.
Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse.
William A Comrie, Janis K Burkhardt.
Front Immunol, 2016 Mar 26; 7. PMID: 27014258    Free PMC article.
Leveraging immunotherapy for the treatment of gynecologic cancers in the era of precision medicine.
Dmitriy Zamarin, Amir A Jazaeri.
Gynecol Oncol, 2016 Mar 27; 141(1). PMID: 27016233    Free PMC article.
Molecular alterations in the TCR signaling pathway in patients with aplastic anemia.
Bo Li, Lixing Guo, +7 authors, Yangqiu Li.
J Hematol Oncol, 2016 Apr 03; 9. PMID: 27036622    Free PMC article.
Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study.
Eric D Donnenfeld, Paul M Karpecki, +4 authors, Charles P Semba.
Cornea, 2016 Apr 08; 35(6). PMID: 27055211    Free PMC article.
Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function.
Soumaya Kouidhi, Muhammad Zaeem Noman, +2 authors, Salem Chouaib.
Front Immunol, 2016 Apr 12; 7. PMID: 27066006    Free PMC article.
Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus.
B A Sullivan, W Tsuji, +9 authors, J B Chung.
Lupus Sci Med, 2016 Apr 22; 3(1). PMID: 27099766    Free PMC article.
Potentiation of immunomodulatory antibody therapy with oncolytic viruses for treatment of cancer.
Dmitriy Zamarin, Jedd D Wolchok.
Mol Ther Oncolytics, 2014 Jan 01; 1. PMID: 27119094    Free PMC article.
Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools.
Jared Klarquist, Zhenyuan Zhou, Nan Shen, Edith M Janssen.
Mediators Inflamm, 2016 Apr 29; 2016. PMID: 27122656    Free PMC article.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
Itay Tirosh, Benjamin Izar, +34 authors, Levi A Garraway.
Science, 2016 Apr 29; 352(6282). PMID: 27124452    Free PMC article.
Highly Cited.
Pembrolizumab in classical Hodgkin's lymphoma.
Joseph Maly, Lapo Alinari.
Eur J Haematol, 2016 May 06; 97(3). PMID: 27147112    Free PMC article.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.
Daniel E Lowther, Brittany A Goods, +10 authors, David A Hafler.
JCI Insight, 2016 May 18; 1(5). PMID: 27182555    Free PMC article.
Highly Cited.
Expression of PD-1 on CD4+ T cells in peripheral blood associates with poor clinical outcome in non-small cell lung cancer.
Hong Zheng, Xin Liu, +7 authors, Chandra P Belani.
Oncotarget, 2016 May 19; 7(35). PMID: 27191652    Free PMC article.
Programmed death-ligand-1 expression in advanced gastric cancer detected with RNA in situ hybridization and its clinical significance.
Jiajia Yuan, Jie Zhang, +8 authors, Lin Shen.
Oncotarget, 2016 Oct 26; 7(26). PMID: 27191996    Free PMC article.
CD28 Costimulation: From Mechanism to Therapy.
Jonathan H Esensten, Ynes A Helou, +2 authors, Jeffrey A Bluestone.
Immunity, 2016 May 19; 44(5). PMID: 27192564    Free PMC article.
Highly Cited. Review.
Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation-Novel Paradigm and Therapeutic Potential.
Xin Wang, Ya-Feng Li, +9 authors, Xiao-Feng Yang.
J Cardiovasc Transl Res, 2016 May 28; 9(4). PMID: 27230673    Free PMC article.
Checkpoint Inhibitors and Their Application in Breast Cancer.
Davide Bedognetti, Cristina Maccalli, +2 authors, Barbara Seliger.
Breast Care (Basel), 2016 May 31; 11(2). PMID: 27239172    Free PMC article.
Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.
Ewa Kozela, Ana Juknat, +3 authors, Zvi Vogel.
J Neuroinflammation, 2016 Jun 04; 13(1). PMID: 27256343    Free PMC article.
Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway.
Rong Wang, Aizhang Xu, +4 authors, Jim Xiang.
Cell Mol Immunol, 2016 Jun 07; 14(6). PMID: 27264687    Free PMC article.
A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.
Benjamin Goetz, Wei An, +7 authors, Hamid Band.
Oncotarget, 2016 Jun 09; 7(32). PMID: 27276677    Free PMC article.
Effector, Memory, and Dysfunctional CD8(+) T Cell Fates in the Antitumor Immune Response.
John Reiser, Arnob Banerjee.
J Immunol Res, 2016 Jun 18; 2016. PMID: 27314056    Free PMC article.
CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.
Zong-Sheng Tang, You-Hua Hao, +4 authors, Dong-Liang Yang.
Mol Med Rep, 2016 Jun 18; 14(2). PMID: 27314219    Free PMC article.
Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein Interaction.
Rushikesh Sable, Thomas Durek, +4 authors, Seetharama Jois.
ACS Chem Biol, 2016 Jun 24; 11(8). PMID: 27337048    Free PMC article.
A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.
Jennifer M Dan, Cecilia S Lindestam Arlehamn, +7 authors, Shane Crotty.
J Immunol, 2016 Jun 28; 197(3). PMID: 27342848    Free PMC article.
Highly Cited.
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response.
Junjie Zhang, Hao Feng, +7 authors, Pinghui Feng.
Cell Rep, 2016 Jun 28; 16(2). PMID: 27346349    Free PMC article.
Differential Expression of Immune Checkpoint Modulators on In Vitro Primed CD4(+) and CD8(+) T Cells.
Nina C Sabins, Benjamin C Harman, +2 authors, Sandra Santulli-Marotto.
Front Immunol, 2016 Jul 06; 7. PMID: 27379090    Free PMC article.
Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups.
Dvir Netanely, Ayelet Avraham, +2 authors, Ron Shamir.
Breast Cancer Res, 2016 Jul 09; 18(1). PMID: 27386846    Free PMC article.
Role of cellular events in the pathophysiology of sepsis.
Chandra Bhan, Pankaj Dipankar, Papiya Chakraborty, Pranita P Sarangi.
Inflamm Res, 2016 Jul 10; 65(11). PMID: 27392441
CD28 days later: Resurrecting costimulation for CD8(+) memory T cells.
Verena van der Heide, Dirk Homann.
Eur J Immunol, 2016 Jul 13; 46(7). PMID: 27401871    Free PMC article.
T Cells Going Innate.
Midas Seyda, Abdallah Elkhal, +2 authors, Stefan G Tullius.
Trends Immunol, 2016 Jul 13; 37(8). PMID: 27402226    Free PMC article.
Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.
Matthias Hoffmann, Nikos Pantazis, +16 authors, SPARTAC and CHERUB Investigators.
PLoS Pathog, 2016 Jul 16; 12(7). PMID: 27415828    Free PMC article.
Highly Cited.
CD137-CRDI is not necessary in the role of contacting its natural ligand.
Ling Yi, Zhuohong Yan, +3 authors, Hongtao Zhang.
Immunol Cell Biol, 2016 Jul 20; 95(1). PMID: 27430526
Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300.
Yun-Ji Jeung, Han-Gyeul Kim, +9 authors, Kyung-Sook Chung.
Biochim Biophys Acta, 2016 Jul 28; 1863(11). PMID: 27452907
Flt3 Ligand Treatment Attenuates T Cell Dysfunction and Improves Survival in a Murine Model of Burn Wound Sepsis.
Naeem K Patil, Julia K Bohannon, +5 authors, Edward R Sherwood.
Shock, 2016 Jul 28; 47(1). PMID: 27454384    Free PMC article.
T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions.
Zeynep Sener, Fritjof H Cederkvist, +2 authors, Bjørn S Skålhegg.
PLoS One, 2016 Jul 29; 11(7). PMID: 27467144    Free PMC article.
Contemporary Treatment of Metastatic Renal Cell Carcinoma.
Igor Stukalin, Nimira Alimohamed, Daniel Y C Heng.
Oncol Rev, 2016 Jul 30; 10(1). PMID: 27471582    Free PMC article.
Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy.
Aitziber Buqué, Norma Bloy, +10 authors, Lorenzo Galluzzi.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471617    Free PMC article.
CD28 co-stimulation in T-cell homeostasis: a recent perspective.
Niklas Beyersdorf, Thomas Kerkau, Thomas Hünig.
Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471717    Free PMC article.
Costimulation Blockade in Kidney Transplantation: An Update.
Paolo Malvezzi, Thomas Jouve, Lionel Rostaing.
Transplantation, 2016 Oct 25; 100(11). PMID: 27472094    Free PMC article.
Enhanced Requirement for TNFR2 in Graft Rejection Mediated by Low-Affinity Memory CD8+ T Cells during Heterologous Immunity.
Scott M Krummey, Ching-Wen Chen, +4 authors, Mandy L Ford.
J Immunol, 2016 Aug 03; 197(5). PMID: 27481849    Free PMC article.
Immune checkpoints and the HIV-1 reservoir: proceed with caution.
Rikke Olesen, Steffen Leth, +4 authors, Martin Tolstrup.
J Virus Erad, 2016 Aug 03; 2(3). PMID: 27482460    Free PMC article.
Ubc13: the Lys63 ubiquitin chain building machine.
Curtis D Hodge, Leo Spyracopoulos, J N Mark Glover.
Oncotarget, 2016 Aug 04; 7(39). PMID: 27486774    Free PMC article.
Classification of Advanced Human Cancers Based on Tumor Immunity in the MicroEnvironment (TIME) for Cancer Immunotherapy.
Yu Zhang, Lieping Chen.
JAMA Oncol, 2016 Aug 05; 2(11). PMID: 27490017    Free PMC article.
Antigen Presentation After Stroke.
Francesc Miró-Mur, Xabier Urra, +2 authors, Anna M Planas.
Neurotherapeutics, 2016 Oct 21; 13(4). PMID: 27514673    Free PMC article.
Emerging infection and sepsis biomarkers: will they change current therapies?
Lauren Jacobs, Hector R Wong.
Expert Rev Anti Infect Ther, 2016 Aug 18; 14(10). PMID: 27533847    Free PMC article.
Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation.
Lindsay J Celada, Joseph E Rotsinger, +4 authors, Wonder P Drake.
Am J Respir Cell Mol Biol, 2016 Aug 27; 56(1). PMID: 27564547    Free PMC article.
Complementing T-cell Function: An Inhibitory Role of the Complement System in T-cell-Mediated Antitumor Immunity.
Weiyi Peng, Jodi A McKenzie, Patrick Hwu.
Cancer Discov, 2016 Sep 03; 6(9). PMID: 27587467    Free PMC article.
Specific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis.
Elia Moreno-Cubero, Juan-Ramón Larrubia.
World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605882    Free PMC article.
An alternative mode of CD43 signal transduction activates pro-survival pathways of T lymphocytes.
Maria Elena Bravo-Adame, Rosario Vera-Estrella, +5 authors, Yvonne Rosenstein.
Immunology, 2016 Sep 09; 150(1). PMID: 27606486    Free PMC article.
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
Mark J Selby, John J Engelhardt, +11 authors, Alan J Korman.
PLoS One, 2016 Sep 10; 11(9). PMID: 27610613    Free PMC article.
Highly Cited.
Risk stratification and immunogenetic risk for infections following stem cell transplantation.
Agnieszka Wójtowicz, Pierre-Yves Bochud.
Virulence, 2016 Sep 11; 7(8). PMID: 27612400    Free PMC article.
Forsythoside A Inhibits BVDV Replication via TRAF2-Dependent CD28-4-1BB Signaling in Bovine PBMCs.
Quan-Jiang Song, Xiao-Gang Weng, +2 authors, Jiu-Feng Wang.
PLoS One, 2016 Sep 13; 11(9). PMID: 27617959    Free PMC article.
OMIP-036: Co-inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets.
Zachary R Healy, David M Murdoch.
Cytometry A, 2016 Oct 22; 89(10). PMID: 27623134    Free PMC article.
TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis.
Xinru Zhou, Yong Mao, +12 authors, Xueguang Zhang.
Oncotarget, 2016 Sep 15; 7(41). PMID: 27626488    Free PMC article.
Prevention of allograft rejection in heart transplantation through concurrent gene silencing of TLR and Kinase signaling pathways.
Hongmei Wang, Xusheng Zhang, +8 authors, Weiping Min.
Sci Rep, 2016 Sep 24; 6. PMID: 27659428    Free PMC article.
Tr1-Like T Cells - An Enigmatic Regulatory T Cell Lineage.
Anna Malgorzata White, David C Wraith.
Front Immunol, 2016 Sep 30; 7. PMID: 27683580    Free PMC article.
T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts.
Judith Feucht, Simone Kayser, +10 authors, Tobias Feuchtinger.
Oncotarget, 2016 Oct 07; 7(47). PMID: 27708227    Free PMC article.
A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte predominant Hodgkin lymphoma.
Bianca Schuhmacher, Benjamin Rengstl, +8 authors, Sylvia Hartmann.
Oncotarget, 2016 Oct 07; 7(44). PMID: 27708232    Free PMC article.
Malignant inflammation in cutaneous T-cell lymphoma-a hostile takeover.
Thorbjørn Krejsgaard, Lise M Lindahl, +6 authors, Niels Odum.
Semin Immunopathol, 2016 Oct 09; 39(3). PMID: 27717961    Free PMC article.
Recombinant human lactoferrin modulates human PBMC derived macrophage responses to BCG and LPS.
Shen-An Hwang, Marian L Kruzel, Jeffrey K Actor.
Tuberculosis (Edinb), 2016 Oct 12; 101S. PMID: 27727130    Free PMC article.
The immune system's role in sepsis progression, resolution, and long-term outcome.
Matthew J Delano, Peter A Ward.
Immunol Rev, 2016 Oct 27; 274(1). PMID: 27782333    Free PMC article.
Highly Cited. Review.
Co-stimulation Blockade Plus T-Cell Depletion in Transplant Patients: Towards a Steroid- and Calcineurin Inhibitor-Free Future?
Florence Herr, Melanie Brunel, Nathalie Roders, Antoine Durrbach.
Drugs, 2016 Oct 28; 76(17). PMID: 27785759
Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy.
Ju Yeon Lee, Hyun Tae Lee, +11 authors, Yong-Seok Heo.
Nat Commun, 2016 Nov 01; 7. PMID: 27796306    Free PMC article.
Highly Cited.
Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.
Jeffrey J Teoh, Awndre E Gamache, +4 authors, Michael G Brown.
J Immunol, 2016 Nov 01; 197(11). PMID: 27798162    Free PMC article.
PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas.
Aaron Goodman, Sandip P Patel, Razelle Kurzrock.
Nat Rev Clin Oncol, 2016 Nov 03; 14(4). PMID: 27805626
Highly Cited. Review.
Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization.
Lei Dong, Alexandra Helmke, +3 authors, Sibylle von Vietinghoff.
Sci Rep, 2016 Nov 04; 6. PMID: 27808281    Free PMC article.
Unraveling the Role of Allo-Antibodies and Transplant Injury.
Yoshiko Matsuda, Minnie M Sarwal.
Front Immunol, 2016 Nov 08; 7. PMID: 27818660    Free PMC article.
LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells.
Sook-Kyoung Heo, Eui-Kyu Noh, +7 authors, Hawk Kim.
PLoS One, 2016 Nov 12; 11(11). PMID: 27835685    Free PMC article.
Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody.
Di Zhang, Monica V Goldberg, Mark L Chiu.
J Biol Chem, 2016 Nov 20; 291(53). PMID: 27856634    Free PMC article.
The CD8 T-cell response during tolerance induction in liver transplantation.
Yik Chun Wong, Geoffrey W McCaughan, David G Bowen, Patrick Bertolino.
Clin Transl Immunology, 2016 Nov 22; 5(10). PMID: 27867515    Free PMC article.
Autoantibodies against CD80 in patients with COPD.
Xu Min Luo, Xin Yan Liu, +4 authors, Xiongbiao Wang.
Clin Transl Immunology, 2016 Nov 22; 5(10). PMID: 27867516    Free PMC article.
T-cell stimuli independently sum to regulate an inherited clonal division fate.
J M Marchingo, G Prevedello, +3 authors, K R Duffy.
Nat Commun, 2016 Nov 22; 7. PMID: 27869196    Free PMC article.
T regulatory cell mediated immunotherapy for solid organ transplantation: A clinical perspective.
Mohammad Afzal Khan.
Mol Med, 2016 Nov 24; 22. PMID: 27878210    Free PMC article.
The emerging role of immune checkpoint inhibition in malignant lymphoma.
Ida Hude, Stephanie Sasse, Andreas Engert, Paul J Bröckelmann.
Haematologica, 2016 Nov 26; 102(1). PMID: 27884973    Free PMC article.
Transplantation tolerance after allograft rejection.
Michelle L Miller, Maria-Luisa Alegre, Anita S Chong.
Curr Opin Organ Transplant, 2016 Nov 30; 22(1). PMID: 27898463    Free PMC article.
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.
Limo Chen, Xiaohui Yi, +13 authors, Don L Gibbons.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999749    Free PMC article.
Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format.
Sina Fellermeier, Nadine Beha, +4 authors, Dafne Müller.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999756    Free PMC article.
Immune targets and neoantigens for cancer immunotherapy and precision medicine.
Rong-Fu Wang, Helen Y Wang.
Cell Res, 2016 Dec 28; 27(1). PMID: 28025978    Free PMC article.
Highly Cited. Review.
Update on immune checkpoint inhibitors in gynecological cancers.
Valerie Heong, Natalie Ngoi, David Shao Peng Tan.
J Gynecol Oncol, 2016 Dec 29; 28(2). PMID: 28028993    Free PMC article.
Unusual CD4+CD28- T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders.
Ga Hye Lee, Won-Woo Lee.
Immune Netw, 2016 Dec 31; 16(6). PMID: 28035207    Free PMC article.
Death receptor 6 contributes to autoimmunity in lupus-prone mice.
Daisuke Fujikura, Masahiro Ikesue, +3 authors, Toshimitsu Uede.
Nat Commun, 2017 Jan 04; 8. PMID: 28045014    Free PMC article.
HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors.
Haruka Kinosada, Jun-Ichirou Yasunaga, +5 authors, Masao Matsuoka.
PLoS Pathog, 2017 Jan 04; 13(1). PMID: 28046066    Free PMC article.
Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung.
A C Zhou, L E Wagar, M E Wortzman, T H Watts.
Mucosal Immunol, 2017 Jan 05; 10(5). PMID: 28051085
Immunoplasticity in cutaneous melanoma: beyond pure morphology.
Francesca Maria Bosisio, Joost J van den Oord.
Virchows Arch, 2017 Jan 06; 470(4). PMID: 28054151
T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger.
Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373    Free PMC article.
Highly Cited. Review.
Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases.
Hyung Jun Woo, Chenggang Yu, Jaques Reifman.
PLoS One, 2017 Jan 13; 12(1). PMID: 28081217    Free PMC article.
CD24: A Rheostat That Modulates Cell Surface Receptor Signaling of Diverse Receptors.
D Craig Ayre, Sherri L Christian.
Front Cell Dev Biol, 2017 Jan 14; 4. PMID: 28083532    Free PMC article.
T-cell receptor-engineered T cells for cancer treatment: current status and future directions.
Yu Ping, Chaojun Liu, Yi Zhang.
Protein Cell, 2017 Jan 22; 9(3). PMID: 28108950    Free PMC article.
Highly Cited. Review.
A human immunodeficiency syndrome caused by mutations in CARMIL2.
T Schober, T Magg, +17 authors, F Hauck.
Nat Commun, 2017 Jan 24; 8. PMID: 28112205    Free PMC article.
New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone.
Siwen Hu-Lieskovan, Antoni Ribas.
Cancer J, 2017 Jan 24; 23(1). PMID: 28114250    Free PMC article.
Therapeutic effect of human ghrelin and growth hormone: Attenuation of immunosuppression in septic aged rats.
Mian Zhou, Weng-Lang Yang, +2 authors, Ping Wang.
Biochim Biophys Acta Mol Basis Dis, 2017 Jan 25; 1863(10 Pt B). PMID: 28115288    Free PMC article.
PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective.
Jun Wang, Ruirong Yuan, +3 authors, Zihai Li.
J Hematol Oncol, 2017 Jan 27; 10(1). PMID: 28122590    Free PMC article.
Highly Cited. Review.
Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity.
Xiao Hu, Xikui Liu, +19 authors, Laura L Carter.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123897    Free PMC article.
Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis.
Elma Kadić, Raymond J Moniz, +2 authors, Ilona Kariv.
BMC Immunol, 2017 Feb 06; 18(1). PMID: 28148223    Free PMC article.
Tumor regulation of the tissue environment in the liver.
Tobias Eggert, Tim F Greten.
Pharmacol Ther, 2017 Feb 09; 173. PMID: 28167218    Free PMC article.
Attenuation of lymphocyte immune responses during Mycobacterium avium complex-induced lung disease due to increasing expression of programmed death-1 on lymphocytes.
Chin-Chung Shu, Jann-Yuan Wang, +5 authors, Chong-Jen Yu.
Sci Rep, 2017 Feb 09; 7. PMID: 28169347    Free PMC article.
CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.
Anna Brewitz, Sarah Eickhoff, +13 authors, Wolfgang Kastenmüller.
Immunity, 2017 Feb 14; 46(2). PMID: 28190711    Free PMC article.
Highly Cited.
Inappropriate costimulation and aberrant DNA methylation as therapeutic targets in angioimmunoblastic T-cell lymphoma.
Mathijs Willemsen, Harry C Schouten.
Biomark Res, 2017 Feb 15; 5. PMID: 28194275    Free PMC article.
Macrophage regulation of B cell proliferation.
Naomi Goldman, Kornelija Valiuskyte, +3 authors, James E Riggs.
Cell Immunol, 2017 Feb 28; 314. PMID: 28238361    Free PMC article.
Interplay between Immune Checkpoint Proteins and Cellular Metabolism.
Sangbin Lim, Joshua B Phillips, +4 authors, Ming Tan.
Cancer Res, 2017 Mar 02; 77(6). PMID: 28246276    Free PMC article.
The Unique Molecular and Cellular Microenvironment of Ovarian Cancer.
Thomas Worzfeld, Elke Pogge von Strandmann, +4 authors, Rolf Müller.
Front Oncol, 2017 Mar 10; 7. PMID: 28275576    Free PMC article.
Highly Cited. Review.
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Enfu Hui, Jeanne Cheung, +8 authors, Ronald D Vale.
Science, 2017 Mar 11; 355(6332). PMID: 28280247    Free PMC article.
Highly Cited.
Old game, new players: Linking classical theories to new trends in transplant immunology.
Marina Burgos da Silva, Flavia Franco da Cunha, Fernanda Fernandes Terra, Niels Olsen Saraiva Camara.
World J Transplant, 2017 Mar 11; 7(1). PMID: 28280691    Free PMC article.
Immunotherapy in pancreatic cancer treatment: a new frontier.
Komal Thind, Leslie J Padrnos, Ramesh K Ramanathan, Mitesh J Borad.
Therap Adv Gastroenterol, 2017 Mar 14; 10(1). PMID: 28286568    Free PMC article.
Dying cells actively regulate adaptive immune responses.
Nader Yatim, Sean Cullen, Matthew L Albert.
Nat Rev Immunol, 2017 Mar 14; 17(4). PMID: 28287107
Highly Cited. Review.
The Microenvironmental Landscape of Brain Tumors.
Daniela F Quail, Johanna A Joyce.
Cancer Cell, 2017 Mar 16; 31(3). PMID: 28292436    Free PMC article.
Highly Cited. Review.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma.
Manohan Sinnadurai, Kerrie L McDonald.
J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764
Interleukin-4 Inhibits Regulatory T Cell Differentiation through Regulating CD103+ Dendritic Cells.
Lei Tu, Jie Chen, Hongwei Zhang, Lihua Duan.
Front Immunol, 2017 Mar 21; 8. PMID: 28316599    Free PMC article.
Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines.
Jason Lohmueller, Olivera J Finn.
Pharmacol Ther, 2017 Mar 23; 178. PMID: 28322974    Free PMC article.
Development of CAR T cells designed to improve antitumor efficacy and safety.
Janneke E Jaspers, Renier J Brentjens.
Pharmacol Ther, 2017 Mar 28; 178. PMID: 28342824    Free PMC article.
Impact of Metabolism on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment.
Soumaya Kouidhi, Amel Benammar Elgaaied, Salem Chouaib.
Front Immunol, 2017 Mar 30; 8. PMID: 28348562    Free PMC article.
STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer.
Rui Li, Fang Fang, +13 authors, Weihua Xiao.
Sci Rep, 2017 Mar 30; 7. PMID: 28350008    Free PMC article.
HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice.
Rashida Ginwala, Breanna Caruso, +8 authors, Pooja Jain.
J Neuroimmune Pharmacol, 2017 Apr 05; 12(3). PMID: 28374110    Free PMC article.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors.
Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri.
Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974    Free PMC article.
In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance.
Ryan M Pearson, Liam M Casey, +2 authors, Lonnie D Shea.
Adv Drug Deliv Rev, 2017 Apr 18; 114. PMID: 28414079    Free PMC article.
PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells.
Xiong Ni, Qingxiao Song, +9 authors, Defu Zeng.
J Clin Invest, 2017 Apr 18; 127(5). PMID: 28414296    Free PMC article.
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.
Melita Irving, Romain Vuillefroy de Silly, +2 authors, George Coukos.
Front Immunol, 2017 Apr 20; 8. PMID: 28421069    Free PMC article.
Phenotypic characterization and anticancer capacity of CD8+ cytokine-induced killer cells after antigen-induced expansion.
Jianhua Liu, Lu Wang, +2 authors, Yilin Cao.
PLoS One, 2017 Apr 21; 12(4). PMID: 28426690    Free PMC article.
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.
Kole T Roybal, Wendell A Lim.
Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446063    Free PMC article.
Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.
Seema Gupta, Amrita Roy, Bilikere S Dwarakanath.
Front Oncol, 2017 Apr 28; 7. PMID: 28447025    Free PMC article.
Highly Cited. Review.
Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.
Na Li, Wenwen Xu, +11 authors, Li Wang.
Sci Rep, 2017 May 05; 7(1). PMID: 28469254    Free PMC article.
B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb.
Xinxin Nie, Wenni Chen, +8 authors, Lieping Chen.
Cell Mol Immunol, 2017 May 10; 15(10). PMID: 28479601    Free PMC article.
Checkpoint inhibitors in hematological malignancies.
Chi Young Ok, Ken H Young.
J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851    Free PMC article.
Highly Cited. Review.
T-cell Co-inhibitory Molecules in Sepsis-induced Immunosuppression: From Bench to Bedside.
Jian-Feng Xie, Hai-Bo Qiu, Yi Yang.
Chin Med J (Engl), 2017 May 10; 130(10). PMID: 28485327    Free PMC article.
Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease.
Andrew S Flies, Nicholas B Blackburn, +2 authors, Gregory M Woods.
Front Immunol, 2017 May 19; 8. PMID: 28515726    Free PMC article.
Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1.
Elizabeth A McNiel, Philip N Tsichlis.
Signal Transduct Target Ther, 2017 May 19; 2. PMID: 28515962    Free PMC article.
Immune Checkpoint in Glioblastoma: Promising and Challenging.
Jing Huang, Fangkun Liu, +4 authors, Jindong Chen.
Front Pharmacol, 2017 May 26; 8. PMID: 28536525    Free PMC article.
Highly Cited. Review.
Rituximab in Minimal Change Disease: Mechanisms of Action and Hypotheses for Future Studies.
Nima Madanchi, Martin Bitzan, Tomoko Takano.
Can J Kidney Health Dis, 2017 May 26; 4. PMID: 28540057    Free PMC article.
Targeting the programmed cell death-1 pathway in rheumatoid arthritis.
Sabina Sandigursky, Gregg J Silverman, Adam Mor.
Autoimmun Rev, 2017 Jun 03; 16(8). PMID: 28572054    Free PMC article.
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy.
Roberta Mazzone, Clemens Zwergel, Antonello Mai, Sergio Valente.
Clin Epigenetics, 2017 Jun 03; 9. PMID: 28572863    Free PMC article.
Highly Cited. Review.
PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells.
Carmen Stecher, Claire Battin, +5 authors, Peter Steinberger.
Front Immunol, 2017 Jun 08; 8. PMID: 28588576    Free PMC article.
Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity.
Ryu Watanabe, Tsuyoshi Shirai, +9 authors, Cornelia M Weyand.
J Clin Invest, 2017 Jun 13; 127(7). PMID: 28604383    Free PMC article.
OX40 promotes obesity-induced adipose inflammation and insulin resistance.
Bing Liu, Hengchi Yu, +11 authors, Dong Zhang.
Cell Mol Life Sci, 2017 Jun 15; 74(20). PMID: 28612217
Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients.
Gijsbert P van Nierop, Marvin M van Luijn, +6 authors, Georges M G M Verjans.
Acta Neuropathol, 2017 Jun 19; 134(3). PMID: 28624961    Free PMC article.
Engineering challenges for brain tumor immunotherapy.
Johnathan G Lyon, Nassir Mokarram, +2 authors, Ravi V Bellamkonda.
Adv Drug Deliv Rev, 2017 Jun 20; 114. PMID: 28625831    Free PMC article.
Genetic alterations in adult T-cell leukemia/lymphoma.
Yasunori Kogure, Keisuke Kataoka.
Cancer Sci, 2017 Jun 20; 108(9). PMID: 28627735    Free PMC article.
The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.
Stephen T Ferris, Pavel N Zakharov, +4 authors, Javier A Carrero.
J Exp Med, 2017 Jun 21; 214(8). PMID: 28630088    Free PMC article.
Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function.
Ahmad Faisal Karim, Scott M Reba, +2 authors, Roxana E Rojas.
Eur J Immunol, 2017 Jul 01; 47(9). PMID: 28665005    Free PMC article.
Dose-Dependent Responses of I3C and DIM on T-Cell Activation in the Human T Lymphocyte Jurkat Cell Line.
Man Liu, Rumana Yasmeen, +3 authors, Thomas T Y Wang.
Int J Mol Sci, 2017 Jul 04; 18(7). PMID: 28671563    Free PMC article.
The emerging role of immune checkpoint based approaches in AML and MDS.
Prajwal Boddu, Hagop Kantarjian, +3 authors, Naval Daver.
Leuk Lymphoma, 2017 Jul 07; 59(4). PMID: 28679300    Free PMC article.
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes.
Garam Choi, Byung-Seok Kim, +2 authors, Yeonseok Chung.
Immune Netw, 2017 Jul 07; 17(3). PMID: 28680377    Free PMC article.
Dendritic Cell Dysfunction in Patients with End-stage Renal Disease.
Ji Ung Kim, Miyeon Kim, +5 authors, Hyunwoo Kim.
Immune Netw, 2017 Jul 07; 17(3). PMID: 28680376    Free PMC article.
THEMIS: Two Models, Different Thresholds.
Seeyoung Choi, Richard Cornall, Renaud Lesourne, Paul E Love.
Trends Immunol, 2017 Jul 13; 38(9). PMID: 28697966    Free PMC article.
Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis.
Hyosun Cho, Hyojeung Kang, Hwan Hee Lee, Chang Wook Kim.
Int J Mol Sci, 2017 Jul 14; 18(7). PMID: 28703774    Free PMC article.
Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab.
Hyun Tae Lee, Ju Yeon Lee, +6 authors, Yong-Seok Heo.
Sci Rep, 2017 Jul 19; 7(1). PMID: 28717238    Free PMC article.
Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis via Targeting Pathogenic Antigen-Specific Th17-Type Cells.
Morad Zayoud, Victoria Marcu-Malina, +5 authors, Itamar Goldstein.
Front Immunol, 2017 Jul 25; 8. PMID: 28736556    Free PMC article.
Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40+ monocyte differentiation.
Jin Dai, Pu Fang, +8 authors, Hong Wang.
J Hematol Oncol, 2017 Jul 26; 10(1). PMID: 28738836    Free PMC article.
Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines.
Namit Holay, Youra Kim, Patrick Lee, Shashi Gujar.
Front Immunol, 2017 Jul 29; 8. PMID: 28751892    Free PMC article.
Immunotherapy in Gastrointestinal Cancers.
Letizia Procaccio, Marta Schirripa, +9 authors, Sara Lonardi.
Biomed Res Int, 2017 Aug 02; 2017. PMID: 28758114    Free PMC article.
Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.
Di Zhang, Anthony A Armstrong, +4 authors, Mark L Chiu.
MAbs, 2017 Aug 02; 9(7). PMID: 28758875    Free PMC article.
Targeting Immune System Alterations in Hodgkin Lymphoma.
Natalie S Grover, Barbara Savoldo.
Curr Hematol Malig Rep, 2017 Aug 07; 12(4). PMID: 28780614    Free PMC article.
Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis.
Stinne R Greisen, Yan Yan, +7 authors, Bent Deleuran.
Front Immunol, 2017 Aug 10; 8. PMID: 28791012    Free PMC article.
Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models.
Melinda Mata, Claudia Gerken, +3 authors, Stephen Gottschalk.
Cancer Discov, 2017 Aug 13; 7(11). PMID: 28801306    Free PMC article.
CD28 and 41BB Costimulation Enhances the Effector Function of CD19-Specific Engager T Cells.
Mireya Paulina Velasquez, Arpad Szoor, +5 authors, Stephen Gottschalk.
Cancer Immunol Res, 2017 Aug 20; 5(10). PMID: 28821531    Free PMC article.
Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.
Aaron M Goodman, Shumei Kato, +6 authors, Razelle Kurzrock.
Mol Cancer Ther, 2017 Aug 25; 16(11). PMID: 28835386    Free PMC article.
Highly Cited.
PD1 signal transduction pathways in T cells.
Hugo Arasanz, Maria Gato-Cañas, +4 authors, David Escors.
Oncotarget, 2017 Sep 09; 8(31). PMID: 28881701    Free PMC article.
Highly Cited. Review.
Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells.
Khalil Eslamloo, Xi Xue, +5 authors, Matthew L Rise.
BMC Genomics, 2017 Sep 10; 18(1). PMID: 28886690    Free PMC article.
Acute Renal Graft-Versus-Host Disease in a Murine Model of Allogeneic Bone Marrow Transplantation.
Peter M Schmid, Abdellatif Bouazzaoui, +5 authors, Dierk H Endemann.
Cell Transplant, 2017 Sep 14; 26(8). PMID: 28901194    Free PMC article.
Peripheral human CD4+CD8+ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15.
Marie-Laure Clénet, François Gagnon, +2 authors, Nathalie Arbour.
Sci Rep, 2017 Sep 16; 7(1). PMID: 28912605    Free PMC article.
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer.
Sathana Dushyanthen, Zhi Ling Teo, +15 authors, Sherene Loi.
Nat Commun, 2017 Sep 21; 8(1). PMID: 28928458    Free PMC article.
CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1+ tumor cells, and extends the survival of tumor-bearing humanized mice.
Lucas A Horn, Nicholas G Ciavattone, +6 authors, Suzanne Ostrand-Rosenberg.
Oncotarget, 2017 Sep 25; 8(35). PMID: 28938530    Free PMC article.
A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation.
Tara Capece, Brandon L Walling, +5 authors, Minsoo Kim.
J Cell Biol, 2017 Sep 29; 216(11). PMID: 28954823    Free PMC article.
Increased Neutralizing Antibody Production and Interferon-γ Secretion in Response to Porcine Reproductive and Respiratory Syndrome Virus Immunization in Genetically Modified Pigs.
Guangping Huang, Xianyong Liu, +6 authors, Xun Suo.
Front Immunol, 2017 Sep 29; 8. PMID: 28955336    Free PMC article.
Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis.
Devy Deliyanti, Dean M Talia, +8 authors, Jennifer L Wilkinson-Berka.
Nat Commun, 2017 Oct 01; 8(1). PMID: 28963474    Free PMC article.
Proteomics and Network Analyses Reveal Inhibition of Akt-mTOR Signaling in CD4+ T Cells by Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan.
Ahmad F Karim, Obondo J Sande, +8 authors, W Henry Boom.
Proteomics, 2017 Oct 11; 17(22). PMID: 28994205    Free PMC article.
Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.
Rachel S Leibman, Max W Richardson, +14 authors, James L Riley.
PLoS Pathog, 2017 Oct 13; 13(10). PMID: 29023549    Free PMC article.
Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction.
Jinshui Chen, Yun Song, +4 authors, Peter Buchwald.
J Med Chem, 2017 Oct 13; 60(21). PMID: 29024591    Free PMC article.
A cellular platform for the evaluation of immune checkpoint molecules.
Sabrina Jutz, Annika Hennig, +7 authors, Peter Steinberger.
Oncotarget, 2017 Oct 17; 8(39). PMID: 29029399    Free PMC article.
A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia.
Shannon K Oda, Andrew W Daman, +5 authors, Philip D Greenberg.
Blood, 2017 Oct 19; 130(22). PMID: 29042364    Free PMC article.
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.
Catherine B Carbone, Nadja Kern, +4 authors, Ronald D Vale.
Proc Natl Acad Sci U S A, 2017 Oct 19; 114(44). PMID: 29042512    Free PMC article.
Tumor-infiltrating CD8+ lymphocytes predict different clinical outcomes in organ- and non-organ-confined urothelial carcinoma of the bladder following radical cystectomy.
Shiqiang Zhang, Jun Wang, Xinyu Zhang, Fangjian Zhou.
PeerJ, 2017 Oct 19; 5. PMID: 29043112    Free PMC article.
T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses.
Rachel E O'Neill, Wei Du, +6 authors, Xuefang Cao.
J Immunol, 2017 Oct 20; 199(10). PMID: 29046346    Free PMC article.
Analysis of the regulatory function of natural killer cells from patients with systemic lupus erythematosus.
D de J Cruz-González, D Gómez-Martin, +5 authors, A E Monsiváis-Urenda.
Clin Exp Immunol, 2017 Oct 24; 191(3). PMID: 29058308    Free PMC article.
A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator.
John R Šedý, M Olivia Balmert, +6 authors, Carl F Ware.
J Biol Chem, 2017 Oct 25; 292(51). PMID: 29061848    Free PMC article.
Identification of 14-dehydroergosterol as a novel anti-inflammatory compound inducing tolerogenic dendritic cells.
Yasuhisa Ano, Kumiko Ikado, +2 authors, Daisuke Fujiwara.
Sci Rep, 2017 Oct 27; 7(1). PMID: 29066789    Free PMC article.
Longitudinal assessment of T cell inhibitory receptors in liver transplant recipients and their association with posttransplant infections.
Krupa R Mysore, Rafik M Ghobrial, +5 authors, Xian C Li.
Am J Transplant, 2017 Oct 27; 18(2). PMID: 29068155    Free PMC article.
New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review.
Joop E Arends, Faydra I Lieveld, Shazaad Ahmad, Andrew Ustianowski.
Infect Dis Ther, 2017 Oct 27; 6(4). PMID: 29071665    Free PMC article.
Src-family kinases negatively regulate NFAT signaling in resting human T cells.
Alan Baer, Winston Colon-Moran, +2 authors, Nirjal Bhattarai.
PLoS One, 2017 Oct 27; 12(10). PMID: 29073235    Free PMC article.
Intestinal Barrier Interactions with Specialized CD8 T Cells.
Špela Konjar, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen.
Front Immunol, 2017 Oct 28; 8. PMID: 29075263    Free PMC article.
c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals.
Christopher D Nishimura, Daniel A Brenner, +9 authors, Caroline Arber.
Blood, 2017 Oct 29; 130(25). PMID: 29079582    Free PMC article.
Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies.
Maksim Mamonkin, Malini Mukherjee, +6 authors, Malcolm K Brenner.
Cancer Immunol Res, 2017 Oct 29; 6(1). PMID: 29079655    Free PMC article.
Potential Immunotherapeutics for Immunosuppression in Sepsis.
Jinwook Shin, Mirim Jin.
Biomol Ther (Seoul), 2017 Oct 31; 25(6). PMID: 29081088    Free PMC article.
Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.
Rafal M Pielak, Geoff P O'Donoghue, +4 authors, Jay T Groves.
Proc Natl Acad Sci U S A, 2017 Nov 01; 114(46). PMID: 29087297    Free PMC article.
Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives.
Lidia M Yshii, Reinhard Hohlfeld, Roland S Liblau.
Nat Rev Neurol, 2017 Nov 07; 13(12). PMID: 29104289
Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production.
Fanny Polesso, Minhazur Sarker, +2 authors, Susan E Murray.
Sci Rep, 2017 Nov 09; 7(1). PMID: 29116141    Free PMC article.
T-cell responses against rhinovirus species A and C in asthmatic and healthy children.
Cibele M Gaido, Caitlyn Granland, +4 authors, Belinda J Hales.
Immun Inflamm Dis, 2017 Nov 11; 6(1). PMID: 29124902    Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer.
R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs.
Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554    Free PMC article.
Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4.
Xuan Mo, Hanghang Zhang, +7 authors, M Raza Zaidi.
Cancer Res, 2017 Nov 19; 78(2). PMID: 29150430    Free PMC article.
Diabetes and Sepsis: Risk, Recurrence, and Ruination.
Lynn M Frydrych, Fatemeh Fattahi, +2 authors, Matthew J Delano.
Front Endocrinol (Lausanne), 2017 Nov 23; 8. PMID: 29163354    Free PMC article.
Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab.
Fei Zhang, Xiaoqiang Qi, +9 authors, Ying Zheng.
Oncotarget, 2017 Nov 23; 8(52). PMID: 29163822    Free PMC article.
Checkpoint inhibitors in endometrial cancer: preclinical rationale and clinical activity.
Gloria Mittica, Eleonora Ghisoni, +3 authors, Giorgio Valabrega.
Oncotarget, 2017 Nov 23; 8(52). PMID: 29163851    Free PMC article.
Aplastic anemia is related to alterations in T cell receptor signaling.
Yankai Xiao, Suwen Zhao, Bo Li.
Stem Cell Investig, 2017 Nov 24; 4. PMID: 29167806    Free PMC article.
Introducing Membrane Charge and Membrane Potential to T Cell Signaling.
Yuanqing Ma, Kate Poole, Jesse Goyette, Katharina Gaus.
Front Immunol, 2017 Nov 25; 8. PMID: 29170669    Free PMC article.
Tumor-targeted costimulation with antibody-fusion proteins improves bispecific antibody-mediated immune response in presence of immunosuppressive factors.
Sabrina Sapski, Nadine Beha, Roland Kontermann, Dafne Müller.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209565    Free PMC article.
Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications.
Mariona Cabo, Rienk Offringa, +3 authors, Lorenzo Galluzzi.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209572    Free PMC article.
Immunotherapy and gene therapy as novel treatments for cancer.
Martha Montserrat Rangel-Sosa, Estuardo Aguilar-Córdova, Augusto Rojas-Martínez.
Colomb Med (Cali), 2017 Dec 08; 48(3). PMID: 29213157    Free PMC article.
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling.
Sarah E Josefsson, Kanutte Huse, +10 authors, June H Myklebust.
Clin Cancer Res, 2017 Dec 09; 24(4). PMID: 29217528    Free PMC article.
The Future of Immunotherapy: A 20-Year Perspective.
David C Wraith.
Front Immunol, 2017 Dec 14; 8. PMID: 29234325    Free PMC article.
T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse.
Tobias X Dong, Shivashankar Othy, +5 authors, Michael D Cahalan.
Elife, 2017 Dec 15; 6. PMID: 29239725    Free PMC article.
A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.
Camille Danne, Grigory Ryzhakov, +7 authors, Fiona Powrie.
Cell Host Microbe, 2017 Dec 15; 22(6). PMID: 29241040    Free PMC article.
PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?
Sylvain Simon, Nathalie Labarriere.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296515    Free PMC article.
Highly Cited. Review.
Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy.
Neus Martinez-Bosch, Judith Vinaixa, Pilar Navarro.
Cancers (Basel), 2018 Jan 06; 10(1). PMID: 29301364    Free PMC article.
Highly Cited. Review.
Acute stimulation generates Tim-3-expressing T helper type 1 CD4 T cells that persist in vivo and show enhanced effector function.
Jacob V Gorman, John D Colgan.
Immunology, 2018 Jan 10; 154(3). PMID: 29315553    Free PMC article.
Combined SEP and anti-PD-L1 antibody produces a synergistic antitumor effect in B16-F10 melanoma-bearing mice.
Zhengping Hu, Liang Ye, +2 authors, Tao Xi.
Sci Rep, 2018 Jan 11; 8(1). PMID: 29317734    Free PMC article.
Improved Cytotoxic T Lymphocyte Responses to Vaccination with Porcine Reproductive and Respiratory Syndrome Virus in 4-1BB Transgenic Pigs.
Guangping Huang, Xianyong Liu, +5 authors, Qiuyan Li.
Front Immunol, 2018 Jan 13; 8. PMID: 29326720    Free PMC article.
Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma.
Caryn L Elsegood, Janina Ee Tirnitz-Parker, John K Olynyk, George Ct Yeoh.
Clin Transl Immunology, 2018 Jan 13; 6(11). PMID: 29326816    Free PMC article.
The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells.
Emily N Pawlak, Brennan S Dirk, +2 authors, Jimmy D Dikeakos.
Retrovirology, 2018 Jan 14; 15(1). PMID: 29329537    Free PMC article.
FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody.
Di Zhang, Brian Whitaker, Mehabaw G Derebe, Mark L Chiu.
MAbs, 2018 Jan 24; 10(3). PMID: 29359992    Free PMC article.
Clinical Development of PD-1 in Advanced Melanoma.
Rodrigo Ramella Munhoz, Michael Andrew Postow.
Cancer J, 2018 Jan 24; 24(1). PMID: 29360722    Free PMC article.
Clinical Development of PD-1 Blockade in Hematologic Malignancies.
Matthew J Pianko, Aaron D Goldberg, Alexander M Lesokhin.
Cancer J, 2018 Jan 24; 24(1). PMID: 29360725    Free PMC article.
Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors.
Shifaa M Abdin, Dana M Zaher, El-Shaimaa A Arafa, Hany A Omar.
Cancers (Basel), 2018 Jan 26; 10(2). PMID: 29370105    Free PMC article.
The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation.
Wenwen Xu, TạMinh Hiếu, Subramaniam Malarkannan, Li Wang.
Cell Mol Immunol, 2018 Jan 30; 15(5). PMID: 29375120    Free PMC article.
Multifunctional nanoparticles for cancer immunotherapy: A groundbreaking approach for reprogramming malfunctioned tumor environment.
Samaresh Sau, Hashem O Alsaab, +3 authors, Arun K Iyer.
J Control Release, 2018 Feb 03; 274. PMID: 29391232    Free PMC article.
Highly Cited. Review.
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis.
Eleanor A Fallon, Bethany M Biron-Girard, +4 authors, Alfred Ayala.
J Leukoc Biol, 2018 Feb 03;. PMID: 29393983    Free PMC article.
CD80/CD86 signaling contributes to the proinflammatory response of Staphylococcus aureus in the airway.
Dane Parker.
Cytokine, 2018 Feb 07; 107. PMID: 29402722    Free PMC article.
Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse.
Katarzyna I Jankowska, Edward K Williamson, +4 authors, Janis K Burkhardt.
Front Immunol, 2018 Feb 07; 9. PMID: 29403502    Free PMC article.
Dichotomous roles of co-stimulatory molecules in diabetes mellitus.
Ji-Xin Zhong, Jie Chen, Xiaoquan Rao, Lihua Duan.
Oncotarget, 2018 Feb 09; 9(2). PMID: 29416823    Free PMC article.
Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection.
Carolina Firacative, A Elisabeth Gressler, +5 authors, Gottfried Alber.
Sci Rep, 2018 Feb 10; 8(1). PMID: 29422616    Free PMC article.
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
Iris Hecht, Amir Toporik, +25 authors, Galit Rotman.
J Immunol, 2018 Feb 13; 200(6). PMID: 29431694    Free PMC article.
GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg.
Keman Xu, William Y Yang, +6 authors, Xiaofeng Yang.
Front Immunol, 2018 Feb 13; 9. PMID: 29434588    Free PMC article.
Prognostic value of PD -L1 expression in patients with primary solid tumors.
Xiao Xiang, Peng-Cheng Yu, +5 authors, Le-Qun Li.
Oncotarget, 2018 Feb 13; 9(4). PMID: 29435162    Free PMC article.
Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design.
Sitanshu S Singh, Seetharama D Jois.
Adv Protein Chem Struct Biol, 2018 Feb 21; 111. PMID: 29459028    Free PMC article.
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.
Eleni Panagioti, Paul Klenerman, +2 authors, Ramon Arens.
Front Immunol, 2018 Mar 06; 9. PMID: 29503649    Free PMC article.
B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction.
Ling Chen, Takeshi Azuma, +3 authors, Lieping Chen.
Proc Natl Acad Sci U S A, 2018 Mar 07; 115(12). PMID: 29507197    Free PMC article.
Role of Polyamines in Immune Cell Functions.
Rebecca S Hesterberg, John L Cleveland, Pearlie K Epling-Burnette.
Med Sci (Basel), 2018 Mar 09; 6(1). PMID: 29517999    Free PMC article.
Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?
Eros Marín, Maria Cristina Cuturi, Aurélie Moreau.
Front Immunol, 2018 Mar 10; 9. PMID: 29520275    Free PMC article.
CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.
Katarina Stanko, Christina Iwert, +11 authors, Birgit Sawitzki.
Proc Natl Acad Sci U S A, 2018 Mar 14; 115(13). PMID: 29531070    Free PMC article.
Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients.
Denise C Hsu, Kimberly F Breglio, +12 authors, Irini Sereti.
Clin Infect Dis, 2018 Mar 15; 67(3). PMID: 29538651    Free PMC article.
Next generation of immune checkpoint therapy in cancer: new developments and challenges.
Julian A Marin-Acevedo, Bhagirathbhai Dholaria, +3 authors, Yanyan Lou.
J Hematol Oncol, 2018 Mar 17; 11(1). PMID: 29544515    Free PMC article.
Highly Cited. Review.
RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells.
David Vallois, Aurélie Dupuy, +15 authors, Laurence de Leval.
Haematologica, 2018 Mar 17; 103(8). PMID: 29545337    Free PMC article.
Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.
Taylor T Chrisikos, Yifan Zhou, +3 authors, Haiyan S Li.
Mol Immunol, 2018 Mar 20; 110. PMID: 29549977    Free PMC article.
Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta.
Marjolein W J Wentink, Yvonne M Mueller, +5 authors, Peter D Katsikis.
Front Immunol, 2018 Mar 23; 9. PMID: 29563914    Free PMC article.
Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells.
Thomas Menter, Alexandar Tzankov.
Front Oncol, 2018 Mar 23; 8. PMID: 29564225    Free PMC article.
The Effect of a Competitive Futsal Match on T Lymphocyte Surface Receptor Signaling and Functions.
Maria F Cury-Boaventura, Renata Gorjão, +8 authors, Elaine Hatanaka.
Front Physiol, 2018 Mar 31; 9. PMID: 29599721    Free PMC article.
Prediction of treatment responses to neoadjuvant chemotherapy in triple-negative breast cancer by analysis of immune checkpoint protein expression.
Yuka Asano, Shinichiro Kashiwagi, +9 authors, Masaichi Ohira.
J Transl Med, 2018 Apr 05; 16(1). PMID: 29615063    Free PMC article.
CD8+ T Cells and NK Cells: Parallel and Complementary Soldiers of Immunotherapy.
Jillian Rosenberg, Jun Huang.
Curr Opin Chem Eng, 2018 Apr 07; 19. PMID: 29623254    Free PMC article.
A T cell equation as a conceptual model of T cell responses for maximizing the efficacy of cancer immunotherapy.
Haidong Dong, Yiyi Yan, Roxana S Dronca, Svetomir N Markovic.
SOJ Immunol, 2017 Jan 01; 5(1). PMID: 29629436    Free PMC article.
Programmed self-assembly of peptide-major histocompatibility complex for antigen-specific immune modulation.
Chih-Ping Mao, Shiwen Peng, +4 authors, T-C Wu.
Proc Natl Acad Sci U S A, 2018 Apr 11; 115(17). PMID: 29632186    Free PMC article.
S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity.
Jinhua Zhang, Kun Song, +6 authors, Zhihai Qin.
Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632708    Free PMC article.
Evaluation of programmed cell death protein 1 (PD-1) expression as a prognostic biomarker in patients with clear cell renal cell carcinoma.
Kyu Seo Kim, Rishi R Sekar, +5 authors, Viraj A Master.
Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632730    Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
TGF-β1 expression in regulatory NK1.1-CD4+NKG2D+ T cells dependents on the PI3K-p85α/JNK, NF-κB and STAT3 pathways.
Sen Han, Shizhen Ding, +9 authors, Weijuan Gong.
Am J Cancer Res, 2018 Apr 11; 8(3). PMID: 29637003    Free PMC article.
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation.
Joanne K Gardner, Scott M J Cornwall, +5 authors, Delia J Nelson.
PLoS One, 2018 Apr 14; 13(4). PMID: 29652910    Free PMC article.
Increased vessel perfusion predicts the efficacy of immune checkpoint blockade.
Xichen Zheng, Zhaoxu Fang, +17 authors, Yuhui Huang.
J Clin Invest, 2018 Apr 18; 128(5). PMID: 29664018    Free PMC article.
A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy.
Yu Mi, Christof C Smith, +5 authors, Andrew Z Wang.
Adv Mater, 2018 Apr 25; 30(25). PMID: 29691900    Free PMC article.
T Cell Calcium Signaling Regulation by the Co-Receptor CD5.
Claudia M Tellez Freitas, Deborah K Johnson, K Scott Weber.
Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701673    Free PMC article.
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses.
Jang Hwan Cho, James J Collins, Wilson W Wong.
Cell, 2018 May 01; 173(6). PMID: 29706540    Free PMC article.
Highly Cited.
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054.
Yiwen Li, Carmine Carpenito, +18 authors, Michael Kalos.
J Immunother Cancer, 2018 May 02; 6(1). PMID: 29712568    Free PMC article.
Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma.
Tyler J Wildes, Adam Grippin, +5 authors, Duane A Mitchell.
Clin Cancer Res, 2018 May 02; 24(16). PMID: 29712687    Free PMC article.
Expression of LLT1 and its receptor CD161 in lung cancer is associated with better clinical outcome.
Véronique M Braud, Jérôme Biton, +13 authors, Claire Germain.
Oncoimmunology, 2018 May 04; 7(5). PMID: 29721382    Free PMC article.
Immune checkpoint receptors: homeostatic regulators of immunity.
Antonio Riva, Shilpa Chokshi.
Hepatol Int, 2018 May 10; 12(3). PMID: 29740793    Free PMC article.
Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction.
Damir Bojadzic, Jinshui Chen, Oscar Alcazar, Peter Buchwald.
Molecules, 2018 May 13; 23(5). PMID: 29751636    Free PMC article.
Efficient Uptake of Recombinant Lipidated Survivin by Antigen-Presenting Cells Initiates Antigen Cross-Presentation and Antitumor Immunity.
Chen-Yi Chiang, Yi-Jyun Chen, +3 authors, Hsin-Wei Chen.
Front Immunol, 2018 May 15; 9. PMID: 29755461    Free PMC article.
Effects of Fish Oil on HIV-Related Inflammation and Markers of Immunosenescence: A Randomized Clinical Trial.
Barbara Swanson, Joyce Keithley, +5 authors, Anneliese Rosdil.
J Altern Complement Med, 2018 May 16; 24(7). PMID: 29762043    Free PMC article.
Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation.
Xinyuan Li, Luqiao Wang, +4 authors, Xiao-Feng Yang.
J Biol Chem, 2018 May 18; 293(28). PMID: 29769317    Free PMC article.
T Cell Co-Stimulation: Inhibition of Immunosuppression?
Karl-Gösta Sundqvist.
Front Immunol, 2018 May 19; 9. PMID: 29774033    Free PMC article.
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Anna Ohradanova-Repic, Christian Machacek, +18 authors, Hannes Stockinger.
Front Immunol, 2018 May 22; 9. PMID: 29780382    Free PMC article.
Helper T-cell responses and pulmonary fungal infections.
Andrew J McDermott, Bruce S Klein.
Immunology, 2018 May 22; 155(2). PMID: 29781185    Free PMC article.
Aberrant T cell subsets and cytokines expression profile in systemic lupus erythematosus.
Haiyan Zhou, Bailong Hu, +8 authors, Joshua Liao.
Clin Rheumatol, 2018 May 23; 37(9). PMID: 29785672
Influenza vaccination of cancer patients during PD-1 blockade induces serological protection but may raise the risk for immune-related adverse events.
Heinz Läubli, Catharina Balmelli, +10 authors, Sacha I Rothschild.
J Immunother Cancer, 2018 May 24; 6(1). PMID: 29789020    Free PMC article.
Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2).
Zhonghua Pei, Rohan Mendonca, +13 authors, Benjamin D Sellers.
ACS Med Chem Lett, 2018 May 26; 9(5). PMID: 29795752    Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer.
Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang.
J Mol Biol, 2018 May 26; 430(14). PMID: 29800567    Free PMC article.
Defining and Understanding Adaptive Resistance in Cancer Immunotherapy.
Tae Kon Kim, Roy S Herbst, Lieping Chen.
Trends Immunol, 2018 May 29; 39(8). PMID: 29802087    Free PMC article.
Highly Cited. Review.
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses.
Teresa Nguyen, Naze G Avci, +2 authors, Hong Jiang.
Cancers (Basel), 2018 Jun 03; 10(6). PMID: 29857493    Free PMC article.
Murine CMV Expressing the High Affinity NKG2D Ligand MULT-1: A Model for the Development of Cytomegalovirus-Based Vaccines.
Lea Hiršl, Ilija Brizić, +5 authors, Stipan Jonjić.
Front Immunol, 2018 Jun 06; 9. PMID: 29867968    Free PMC article.
CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo.
Daniela Langenhorst, Stephanie Haack, +5 authors, Niklas Beyersdorf.
Front Immunol, 2018 Jun 06; 9. PMID: 29868020    Free PMC article.
CD4+ T Cell Subsets and Pathways to HIV Latency.
Luis M Agosto, Andrew J Henderson.
AIDS Res Hum Retroviruses, 2018 Jun 06; 34(9). PMID: 29869531    Free PMC article.
Chitosan Microsphere Used as an Effective System to Deliver a Linked Antigenic Peptides Vaccine Protect Mice Against Acute and Chronic Toxoplasmosis.
Jingjing Guo, Xiahui Sun, +6 authors, Hua Cong.
Front Cell Infect Microbiol, 2018 Jun 08; 8. PMID: 29876322    Free PMC article.
APVO210: A Bispecific Anti-CD86-IL-10 Fusion Protein (ADAPTIR™) to Induce Antigen-Specific T Regulatory Type 1 Cells.
Laurence Pellerin, Ping Chen, +3 authors, Maria Grazia Roncarolo.
Front Immunol, 2018 Jun 12; 9. PMID: 29887861    Free PMC article.
Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile.
Christiane Querfeld, Samantha Leung, +13 authors, James W Young.
Cancer Immunol Res, 2018 Jun 14; 6(8). PMID: 29895574    Free PMC article.
Antitumor Immunity Is Controlled by Tetraspanin Proteins.
Fleur Schaper, Annemiek B van Spriel.
Front Immunol, 2018 Jun 14; 9. PMID: 29896201    Free PMC article.
Induction and transcriptional regulation of the co-inhibitory gene module in T cells.
Norio Chihara, Asaf Madi, +18 authors, Vijay K Kuchroo.
Nature, 2018 Jun 15; 558(7710). PMID: 29899446    Free PMC article.
Highly Cited.
Albumin/globulin ratio is negatively correlated with PD-1 and CD25 mRNA levels in breast cancer patients.
Chao Liu, Wei Wang, +6 authors, Shikai Wu.
Onco Targets Ther, 2018 Jun 15; 11. PMID: 29899663    Free PMC article.
Current treatment options for psoriatic arthritis: spotlight on abatacept.
Francesco Ursini, Emilio Russo, +2 authors, Salvatore D'Angelo.
Ther Clin Risk Manag, 2018 Jun 21; 14. PMID: 29922065    Free PMC article.
Human αβ and γδ T Cells in Skin Immunity and Disease.
Michelle S Cruz, Alani Diamond, Astrid Russell, Julie Marie Jameson.
Front Immunol, 2018 Jun 22; 9. PMID: 29928283    Free PMC article.
Ligation of Na, K ATPase β3 subunit on monocytes by a specific monoclonal antibody mediates T cell hypofunction.
Nuchjira Takheaw, Witida Laopajon, +3 authors, Watchara Kasinrerk.
PLoS One, 2018 Jun 26; 13(6). PMID: 29940031    Free PMC article.
Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review.
Waseem Lone, Aisha Alkhiniji, Jayadev Manikkam Umakanthan, Javeed Iqbal.
Curr Hematol Malig Rep, 2018 Jun 29; 13(4). PMID: 29951889
T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice.
Jaclyn R Espinosa, Danny Mou, +9 authors, Allan D Kirk.
Front Immunol, 2018 Jul 03; 9. PMID: 29963060    Free PMC article.
CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection.
Vishal Khairnar, Vikas Duhan, +18 authors, Karl S Lang.
Nat Commun, 2018 Jul 04; 9(1). PMID: 29967450    Free PMC article.
Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice.
Marco F Taddio, Linjing Mu, +2 authors, Stefanie D Krämer.
Contrast Media Mol Imaging, 2018 Jul 04; 2018. PMID: 29967572    Free PMC article.
Expression and clinical significance of programmed death ligand 1 in nasopharyngeal carcinoma.
Yuan Qu, Di Wang, +3 authors, Yi-Qun Che.
Mol Clin Oncol, 2018 Jul 07; 9(1). PMID: 29977542    Free PMC article.
Immune Checkpoints as the Immune System Regulators and Potential Biomarkers in HIV-1 Infection.
Maike Sperk, Robert van Domselaar, Ujjwal Neogi.
Int J Mol Sci, 2018 Jul 11; 19(7). PMID: 29987244    Free PMC article.
Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV Cure.
Genevieve Tyndale Clutton, R Brad Jones.
Front Immunol, 2018 Jul 11; 9. PMID: 29988382    Free PMC article.
Association of CD28 and CTLA4 haplotypes with susceptibility to primary Sjögren's syndrome in Mexican population.
Erika Fabiola López-Villalobos, Francisco Josué Carrillo-Ballesteros, +4 authors, Edith Oregon-Romero.
J Clin Lab Anal, 2018 Jul 12; 33(1). PMID: 29992636    Free PMC article.
Massive parallel screening of phage libraries for the generation of repertoires of human immunomodulatory monoclonal antibodies.
Emanuele Sasso, Chiara D'Avino, +9 authors, Claudia De Lorenzo.
MAbs, 2018 Jul 12; 10(7). PMID: 29995563    Free PMC article.
Novel tumour antigens and the development of optimal vaccine design.
Victoria A Brentville, Suha Atabani, Katherine Cook, Lindy G Durrant.
Ther Adv Vaccines Immunother, 2018 Jul 13; 6(2). PMID: 29998219    Free PMC article.
Microbial biomarkers for immune checkpoint blockade therapy against cancer.
Keishi Adachi, Koji Tamada.
J Gastroenterol, 2018 Jul 14; 53(9). PMID: 30003334    Free PMC article.
2B4 Mediates Inhibition of CD8+ T Cell Responses via Attenuation of Glycolysis and Cell Division.
Sonia J Laurie, Danya Liu, +3 authors, Mandy L Ford.
J Immunol, 2018 Jul 18; 201(5). PMID: 30012849    Free PMC article.
Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways.
Alan Baer, Winston Colon-Moran, Nirjal Bhattarai.
Sci Rep, 2018 Jul 22; 8(1). PMID: 30026610    Free PMC article.
Review article: systemic treatment of hepatocellular carcinoma.
Matthias Pinter, Markus Peck-Radosavljevic.
Aliment Pharmacol Ther, 2018 Jul 25; 48(6). PMID: 30039640    Free PMC article.
Pulmonary Infections in Immunocompromised Hosts: Clinical.
Cristina Vazquez Guillamet, Joe Le Hsu, Gundeep Dhillon, Rodrigo Vazquez Guillamet.
J Thorac Imaging, 2018 Jul 27; 33(5). PMID: 30048345    Free PMC article.
Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective.
Somayeh Vandghanooni, Morteza Eskandani, Jaleh Barar, Yadollah Omidi.
J Mol Med (Berl), 2018 Jul 30; 96(9). PMID: 30056527
Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function.
Sophie M Poznanski, Nicole G Barra, Ali A Ashkar, Jonathan D Schertzer.
Inflamm Res, 2018 Aug 02; 67(10). PMID: 30066126
Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling.
Justin Lucas, Tze-Chen Hsieh, +2 authors, Joseph M Wu.
Int J Oncol, 2018 Aug 02; 53(4). PMID: 30066852    Free PMC article.
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity.
Christopher W Helsen, Joanne A Hammill, +14 authors, Jonathan L Bramson.
Nat Commun, 2018 Aug 05; 9(1). PMID: 30076299    Free PMC article.
Neuromuscular Complications of Programmed Cell Death-1 (PD-1) Inhibitors.
Justin C Kao, Adipong Brickshawana, Teerin Liewluck.
Curr Neurol Neurosci Rep, 2018 Aug 06; 18(10). PMID: 30078154
Next Generation Cancer Vaccines-Make It Personal!
Angelika Terbuch, Juanita Lopez.
Vaccines (Basel), 2018 Aug 12; 6(3). PMID: 30096953    Free PMC article.
Producing proT cells to promote immunotherapies.
Jastaranpreet Singh, Juan Carlos Zúñiga-Pflücker.
Int Immunol, 2018 Aug 14; 30(12). PMID: 30102361    Free PMC article.
A Mechanistic Computational Model Reveals That Plasticity of CD4+ T Cell Differentiation Is a Function of Cytokine Composition and Dosage.
Bhanwar Lal Puniya, Robert G Todd, +3 authors, Tomáš Helikar.
Front Physiol, 2018 Aug 18; 9. PMID: 30116195    Free PMC article.
Distinct Changes of BTLA and HVEM Expressions in Circulating CD4+ and CD8+ T Cells in Hepatocellular Carcinoma Patients.
Jiayu Liu, Jiaqian Li, +2 authors, Qiyi Zhao.
J Immunol Res, 2018 Aug 18; 2018. PMID: 30116751    Free PMC article.
Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy.
Paola M Dantonio, Marianne O Klein, +3 authors, Ricardo G Correa.
Biosci Rep, 2018 Sep 01; 38(5). PMID: 30166456    Free PMC article.
Prognostic significance of tumor immune microenvironment and immunotherapy: Novel insights and future perspectives in gastric cancer.
Daniela Cornelia Lazăr, Mihaela Flavia Avram, +3 authors, Adrian Goldiș.
World J Gastroenterol, 2018 Sep 01; 24(32). PMID: 30166856    Free PMC article.
Highly Cited. Review.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity.
Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar.
J Autoimmun, 2018 Sep 04; 95. PMID: 30174217    Free PMC article.
Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses.
Rebecca L Tallmadge, Minghui Wang, Qi Sun, Maria Julia B Felippe.
PLoS One, 2018 Sep 06; 13(9). PMID: 30183726    Free PMC article.
Immune checkpoint inhibitors in melanoma.
Adam J Cooper, Matteo S Carlino, Richard F Kefford.
Melanoma Manag, 2015 Aug 01; 2(3). PMID: 30190854    Free PMC article.
Immune checkpoint inhibitors for hepatocellular carcinoma.
Christopher E Jensen, Arturo Loaiza-Bonilla, Paula A Bonilla-Reyes.
Hepat Oncol, 2016 Aug 01; 3(3). PMID: 30191042    Free PMC article.
Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS.
Takeshi Sugio, Kohta Miyawaki, +8 authors, Koichi Akashi.
Blood Adv, 2018 Sep 09; 2(17). PMID: 30194138    Free PMC article.
New developments in immunotherapy for lymphoma.
Benjamin Heyman, Yiping Yang.
Cancer Biol Med, 2018 Sep 11; 15(3). PMID: 30197788    Free PMC article.
Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling.
Anisur Rahman, Abhinav Tiwari, Jatin Narula, Timothy Hickling.
CPT Pharmacometrics Syst Pharmacol, 2018 Sep 11; 7(10). PMID: 30198637    Free PMC article.
PD-1 has a unique capacity to inhibit allergen-specific human CD4+ T cell responses.
Sandra Rosskopf, Beatrice Jahn-Schmid, +2 authors, Peter Steinberger.
Sci Rep, 2018 Sep 12; 8(1). PMID: 30201974    Free PMC article.
Present and future of cancer immunotherapy: A tumor microenvironmental perspective.
Yu Yu, Jiuwei Cui.
Oncol Lett, 2018 Sep 15; 16(4). PMID: 30214551    Free PMC article.
Proximity ligation assay to study protein-protein interactions of proteins on two different cells.
Rushikesh Sable, Nithya Jambunathan, +3 authors, Seetharama Jois.
Biotechniques, 2018 Sep 20; 65(3). PMID: 30227746    Free PMC article.
Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans.
Sina Fellermeier-Kopf, Friederike Gieseke, +3 authors, Roland E Kontermann.
Oncoimmunology, 2018 Sep 20; 7(9). PMID: 30228940    Free PMC article.
Clostridium novyi-NT in cancer therapy.
Verena Staedtke, Nicholas J Roberts, Ren-Yuan Bai, Shibin Zhou.
Genes Dis, 2016 Feb 06; 3(2). PMID: 30258882    Free PMC article.
Therapeutic vaccination with 4-1BB co-stimulation eradicates mouse acute myeloid leukemia.
Daniel Kerage, Megan S F Soon, +5 authors, Stephen R Mattarollo.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288351    Free PMC article.
The comprehensive molecular landscape of the immunologic co-stimulator B7 and TNFR ligand receptor families in colorectal cancer: immunotherapeutic implications with microsatellite instability.
Jinghua Tang, Wu Jiang, +5 authors, Yingqin Li.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288357    Free PMC article.
A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity.
Meinolf Thiemann, David M Richards, +10 authors, Oliver Hill.
Front Oncol, 2018 Oct 10; 8. PMID: 30298117    Free PMC article.
Control of Immunoregulatory Molecules by miRNAs in T Cell Activation.
Ana Rodríguez-Galán, Lola Fernández-Messina, Francisco Sánchez-Madrid.
Front Immunol, 2018 Oct 16; 9. PMID: 30319616    Free PMC article.
The Role of the Immunological Synapse in Differential Effects of APC Subsets in Alloimmunization to Fresh, Non-stored RBCs.
Amanda L Richards, Kathryn Sheldon, +2 authors, Krystalyn E Hudson.
Front Immunol, 2018 Oct 23; 9. PMID: 30344520    Free PMC article.
Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling.
Theinmozhi Arulraj, Debashis Barik.
PLoS One, 2018 Oct 26; 13(10). PMID: 30356330    Free PMC article.
Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy.
Hanna A Knaus, Sofia Berglund, +9 authors, Ivana Gojo.
JCI Insight, 2018 Nov 06; 3(21). PMID: 30385732    Free PMC article.
An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.
John D Klement, Amy V Paschall, +7 authors, Kebin Liu.
J Clin Invest, 2018 Nov 06; 128(12). PMID: 30395540    Free PMC article.
MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells.
Babita Agrawal, Nancy Gupta, Jeffrey D Konowalchuk.
Front Immunol, 2018 Nov 09; 9. PMID: 30405607    Free PMC article.
Combination Immune Checkpoint Blockade Strategies to Maximize Immune Response in Gynecological Cancers.
Ying L Liu, Dmitriy Zamarin.
Curr Oncol Rep, 2018 Nov 14; 20(12). PMID: 30421009    Free PMC article.
T Cells in Adipose Tissue: Critical Players in Immunometabolism.
Qun Wang, Huaizhu Wu.
Front Immunol, 2018 Nov 22; 9. PMID: 30459770    Free PMC article.
Novel Treatments in Lupus.
Milena Vukelic, Yi Li, Vasileios C Kyttaris.
Front Immunol, 2018 Dec 14; 9. PMID: 30524430    Free PMC article.
Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma.
Benjamin P Hurrell, Pedram Shafiei Jahani, Omid Akbari.
Front Immunol, 2018 Dec 14; 9. PMID: 30524437    Free PMC article.
Herpes Virus Entry Mediator (HVEM) Expression Promotes Inflammation/ Organ Injury in Response to Experimental Indirect-Acute Lung Injury.
Tingting Cheng, Jianwen Bai, +3 authors, Alfred Ayala.
Shock, 2018 Dec 12; 51(4). PMID: 30531604    Free PMC article.
The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections.
Keiko Yasuma-Mitobe, Masao Matsuoka.
Front Immunol, 2018 Dec 13; 9. PMID: 30538707    Free PMC article.
Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells.
Julia Krombach, Roman Hennel, +12 authors, Kirsten Lauber.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546963    Free PMC article.
A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155.
Bushra Husain, Sree R Ramani, +13 authors, Nadia Martinez-Martin.
Mol Cell Proteomics, 2019 Jul 17; 18(11). PMID: 31308249    Free PMC article.
Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit.
Jie Wang, Keke Fei, +11 authors, Junjian Liu.
MAbs, 2019 Aug 14; 11(8). PMID: 31402780    Free PMC article.
Programmed Death Ligand 1 (PD-L1) as a Predictive Biomarker for Pembrolizumab Therapy in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC).
Lorena Incorvaia, Daniele Fanale, +10 authors, Antonio Russo.
Adv Ther, 2019 Aug 23; 36(10). PMID: 31432460    Free PMC article.
Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis.
Qian Li, Yan Yan, +8 authors, Mengji Lu.
Front Immunol, 2019 Oct 02; 10. PMID: 31572396    Free PMC article.
Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation.
Xiaoli Wang, Sytse J Piersma, +6 authors, Daved H Fremont.
Proc Natl Acad Sci U S A, 2019 Oct 03; 116(42). PMID: 31575740    Free PMC article.
The Role of Immune Checkpoint Receptors in Regulating Immune Reactivity in Lupus.
Kun-Lin Lu, Ming-Ying Wu, +4 authors, Chun-Bing Chen.
Cells, 2019 Oct 11; 8(10). PMID: 31597242    Free PMC article.
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention.
Anna Aiello, Farzin Farzaneh, +6 authors, Giulia Accardi.
Front Immunol, 2019 Oct 15; 10. PMID: 31608061    Free PMC article.
Highly Cited. Review.
Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors.
Giuseppe Schepisi, Nicole Brighi, +11 authors, Ugo De Giorgi.
J Oncol, 2019 Oct 24; 2019. PMID: 31641355    Free PMC article.
The Pathogenesis of Sepsis and Potential Therapeutic Targets.
Min Huang, Shaoli Cai, Jingqian Su.
Int J Mol Sci, 2019 Nov 02; 20(21). PMID: 31671729    Free PMC article.
Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells.
Trine B Levring, Martin Kongsbak-Wismann, +7 authors, Carsten Geisler.
Sci Rep, 2019 Nov 15; 9(1). PMID: 31723203    Free PMC article.
Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer.
So Mee Kwon, Anuradha Budhu, +10 authors, Xin Wei Wang.
Sci Rep, 2019 Nov 16; 9(1). PMID: 31729408    Free PMC article.
Hypomethylating agents in combination with immune checkpoint inhibitors in acute myeloid leukemia and myelodysplastic syndromes.
Naval Daver, Prajwal Boddu, +4 authors, Hagop Kantarjian.
Leukemia, 2018 Mar 01; 32(5). PMID: 29487386    Free PMC article.
Highly Cited. Review.
OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling.
Prabhakaran Kumar, Swarali Surendra Lele, +4 authors, Bellur S Prabhakar.
J Immunol, 2019 Nov 11; 203(12). PMID: 31704879    Free PMC article.
Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition.
Rita C Acúrcio, Carlota Leonardo-Sousa, +3 authors, Rita C Guedes.
Medchemcomm, 2019 Dec 10; 10(10). PMID: 31814954    Free PMC article.
Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors.
Bin Lai, Jiwei Wang, +28 authors, Xiaofeng Yang.
Front Immunol, 2019 Dec 12; 10. PMID: 31824480    Free PMC article.
Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer.
Robert S Svatek, Niannian Ji, +12 authors, Tyler J Curiel.
Cancer Immunol Res, 2018 Dec 20; 7(3). PMID: 30563829    Free PMC article.
Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer.
Katsiaryna Marhelava, Zofia Pilch, +2 authors, Radoslaw Zagozdzon.
Cancers (Basel), 2019 Nov 14; 11(11). PMID: 31717326    Free PMC article.
A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.
Marcus J Taylor, Kabir Husain, +2 authors, Ronald D Vale.
Cell, 2017 Mar 25; 169(1). PMID: 28340336    Free PMC article.
Highly Cited.
An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
Tomasz Slezak, Lucas J Bailey, +4 authors, Anthony A Kossiakoff.
Protein Sci, 2019 Oct 18; 29(1). PMID: 31622515    Free PMC article.
Checkpoint Genes at the Cancer Side of the Immunological Synapse in Bladder Cancer.
Paula Dobosz, Przemysław A Stempor, +6 authors, Raya Leibowitz-Amit.
Transl Oncol, 2019 Dec 24; 13(2). PMID: 31869744    Free PMC article.
Immunology of Adenoviral Vectors in Cancer Therapy.
Amanda Rosewell Shaw, Masataka Suzuki.
Mol Ther Methods Clin Dev, 2020 Jan 01; 15. PMID: 31890734    Free PMC article.
Genetic and Molecular Biology of Multiple Sclerosis Among Iranian Patients: An Overview.
Meysam Moghbeli.
Cell Mol Neurobiol, 2019 Sep 05; 40(1). PMID: 31482432
Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb.
Hao Shi, Nicole M Chapman, +10 authors, Hongbo Chi.
Immunity, 2019 Nov 02; 51(6). PMID: 31668641    Free PMC article.
Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells.
Yeni Romero, Randi Wise, Anna Zolkiewska.
Cancer Immunol Immunother, 2019 Dec 05; 69(1). PMID: 31796994    Free PMC article.
B-cell-specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasion.
Daniela Asslaber, Yuan Qi, +7 authors, Alexander Egle.
Blood, 2019 Sep 21; 134(20). PMID: 31537531    Free PMC article.
CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas.
Kati Tormanen, Shaohui Wang, Homayon Ghiasi.
J Virol, 2019 Oct 18; 94(2). PMID: 31619558    Free PMC article.
Differential Expression of Immune Checkpoint Molecules on CD8+ T Cells Specific for Immunodominant and Subdominant Herpes Simplex Virus 1 Epitopes.
Kate L Carroll, Lyndsay Avery, +4 authors, Anthony J St Leger.
J Virol, 2019 Oct 28; 94(2). PMID: 31645447    Free PMC article.
Herbal Medicines Attenuate PD-L1 Expression to Induce Anti-Proliferation in Obesity-Related Cancers.
Yu-Chen S H Yang, Zi-Lin Li, +5 authors, Kuan Wang.
Nutrients, 2019 Dec 11; 11(12). PMID: 31817534    Free PMC article.
Immune Response in Bacterial and Candida Sepsis.
Patricia Patricio, José Artur Paiva, Luís Miguel Borrego.
Eur J Microbiol Immunol (Bp), 2020 Jan 15; 9(4). PMID: 31934361    Free PMC article.
Peptide-based targeting of immunosuppressive cells in cancer.
Noah T Trac, Eun Ji Chung.
Bioact Mater, 2020 Jan 21; 5(1). PMID: 31956738    Free PMC article.
Enhanced STAT3 phosphorylation and PD-L1 expression in myeloid dendritic cells indicate impaired IL-27Ralpha signaling in type 1 diabetes.
Z Parackova, P Vrabcova, +6 authors, A Sediva.
Sci Rep, 2020 Jan 18; 10(1). PMID: 31949260    Free PMC article.
Antibody Structure and Function: The Basis for Engineering Therapeutics.
Mark L Chiu, Dennis R Goulet, Alexey Teplyakov, Gary L Gilliland.
Antibodies (Basel), 2019 Dec 11; 8(4). PMID: 31816964    Free PMC article.
CD19 CAR T Cells for the Treatment of Pediatric Pre-B Cell Acute Lymphoblastic Leukemia.
Holly L Pacenta, Theodore W Laetsch, Samuel John.
Paediatr Drugs, 2019 Nov 22; 22(1). PMID: 31749131
Structural insight into T cell coinhibition by PD-1H (VISTA).
Benjamin T Slater, Xue Han, Lieping Chen, Yong Xiong.
Proc Natl Acad Sci U S A, 2020 Jan 11; 117(3). PMID: 31919279    Free PMC article.
IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors.
Jonathan H DeLong, Aisling O'Hara Hall, +8 authors, Christopher A Hunter.
Immunohorizons, 2019 Jul 30; 3(1). PMID: 31356173    Free PMC article.
Surface protein imputation from single cell transcriptomes by deep neural networks.
Zilu Zhou, Chengzhong Ye, Jingshu Wang, Nancy R Zhang.
Nat Commun, 2020 Feb 02; 11(1). PMID: 32005835    Free PMC article.
Immunotherapy Is Changing First-Line Treatment of Metastatic Renal-Cell Carcinoma.
Matthew K Labriola, Kristen A Batich, +5 authors, Tian Zhang.
Clin Genitourin Cancer, 2019 Mar 13; 17(3). PMID: 30858035    Free PMC article.
Methylation of immune synapse genes modulates tumor immunogenicity.
Anders Berglund, Matthew Mills, +3 authors, Sungjune Kim.
J Clin Invest, 2019 Nov 13; 130(2). PMID: 31714899    Free PMC article.
Multiscale network analysis reveals molecular mechanisms and key regulators of the tumor microenvironment in gastric cancer.
Won-Min Song, Xiandong Lin, +9 authors, Bin Zhang.
Int J Cancer, 2019 Aug 30; 146(5). PMID: 31463974    Free PMC article.
T-cell exhaustion in HIV infection.
Craig Fenwick, Victor Joo, +4 authors, Giuseppe Pantaleo.
Immunol Rev, 2019 Dec 29; 292(1). PMID: 31883174    Free PMC article.
Immune checkpoint-based therapy in myeloid malignancies: a promise yet to be fulfilled.
Jan Philipp Bewersdorf, Maximilian Stahl, Amer M Zeidan.
Expert Rev Anticancer Ther, 2019 Mar 20; 19(5). PMID: 30887841    Free PMC article.
Toxoplasma: Immunity and Pathogenesis.
Imtiaz A Khan, Charlotte Ouellette, Keer Chen, Magali Moretto.
Curr Clin Microbiol Rep, 2019 Jun 11; 6(1). PMID: 31179204    Free PMC article.
Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer.
Kristin G Anderson, Valentin Voillet, +9 authors, Philip D Greenberg.
Cancer Immunol Res, 2019 Jul 25; 7(9). PMID: 31337659    Free PMC article.
Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features.
Eva Karamitopoulou.
Br J Cancer, 2019 May 22; 121(1). PMID: 31110329    Free PMC article.
Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity.
Hélène G Bazin, Laura S Bess, +5 authors, Jay T Evans.
Bioorg Med Chem Lett, 2020 Feb 01; 30(6). PMID: 32001135    Free PMC article.
Immune Dysregulation in HFpEF: A Target for Mesenchymal Stem/Stromal Cell Therapy.
Ruxandra I Sava, Carl J Pepine, Keith L March.
J Clin Med, 2020 Jan 23; 9(1). PMID: 31963368    Free PMC article.
EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients.
Gongmin Zhu, Lijiao Pei, Yuan Li, Xin Gou.
Aging (Albany NY), 2020 Feb 06; 12(3). PMID: 32012118    Free PMC article.
A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors.
Anna Konstorum, Anthony T Vella, Adam J Adler, Reinhard C Laubenbacher.
Sci Rep, 2019 Jul 28; 9(1). PMID: 31350431    Free PMC article.
Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance.
Radhika R Gudi, Subha Karumuthil-Melethil, +2 authors, Chenthamarakshan Vasu.
Sci Rep, 2019 Aug 21; 9(1). PMID: 31427630    Free PMC article.
Complex human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on germinal center T and B cells.
Angelika Schmidt, Johanna E Huber, +6 authors, Dirk Baumjohann.
EBioMedicine, 2020 Mar 03; 53. PMID: 32114393    Free PMC article.
STING, DCs and the link between innate and adaptive tumor immunity.
Ralph E Vatner, Edith M Janssen.
Mol Immunol, 2017 Dec 24; 110. PMID: 29273394    Free PMC article.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han.
J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595    Free PMC article.
Highly Cited. Review.
In vitro evaluation of dual-antigenic PV1 peptide vaccine in head and neck cancer patients.
San Jiun Chai, Sammuel Chee Yong Fong, +11 authors, Kue Peng Lim.
Hum Vaccin Immunother, 2018 Sep 08; 15(1). PMID: 30193086    Free PMC article.
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells.
Dominik Aschenbrenner, Mathilde Foglierini, +6 authors, Federica Sallusto.
Nat Immunol, 2018 Sep 12; 19(10). PMID: 30201991    Free PMC article.
The challenges of checkpoint inhibition in the treatment of multiple myeloma.
Barry Paul, Shuqi Kang, Zhihong Zheng, Yubin Kang.
Cell Immunol, 2018 Oct 22; 334. PMID: 30342750    Free PMC article.
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
Vincent A Laufer, Hemant K Tiwari, +12 authors, S Louis Bridges.
Hum Mol Genet, 2018 Nov 14; 28(5). PMID: 30423114    Free PMC article.
Biological Consequences of MHC-II Expression by Tumor Cells in Cancer.
Margaret L Axelrod, Rebecca S Cook, Douglas B Johnson, Justin M Balko.
Clin Cancer Res, 2018 Nov 23; 25(8). PMID: 30463850    Free PMC article.
Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes.
Kimberly N Smitheman, Tesa M Severson, +17 authors, Helai P Mohammad.
Haematologica, 2018 Dec 06; 104(6). PMID: 30514804    Free PMC article.
Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation.
Yao Chen, Ryan Zander, +2 authors, Weiguo Cui.
Front Immunol, 2018 Dec 26; 9. PMID: 30581433    Free PMC article.
The Role of Co-stimulatory/Co-inhibitory Signals in Graft-vs.-Host Disease.
Sandeep Kumar, Nicholas D Leigh, Xuefang Cao.
Front Immunol, 2019 Jan 11; 9. PMID: 30627129    Free PMC article.
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma.
Sarah E Josefsson, Klaus Beiske, +12 authors, June H Myklebust.
Cancer Immunol Res, 2019 Jan 20; 7(3). PMID: 30659053    Free PMC article.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.
Takayuki Imanishi, Midori Unno, +11 authors, Takashi Saito.
Life Sci Alliance, 2019 Jan 27; 2(1). PMID: 30683688    Free PMC article.
CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70.
Julia M Laufer, Ilona Kindinger, +2 authors, Daniel F Legler.
Front Immunol, 2019 Jan 30; 9. PMID: 30692994    Free PMC article.
Concise Review: Skeletal Muscle as a Delivery Route for Mesenchymal Stromal Cells.
Shiva Hamidian Jahromi, John E Davies.
Stem Cells Transl Med, 2019 Feb 06; 8(5). PMID: 30720934    Free PMC article.
Peripheral T cell receptor beta immune repertoire is promptly reconstituted after acute myocardial infarction.
Dan Li, Longgang Hu, +4 authors, Kejia Wang.
J Transl Med, 2019 Feb 08; 17(1). PMID: 30728066    Free PMC article.
Immune checkpoint inhibitors.
Enfu Hui.
J Cell Biol, 2019 Feb 15; 218(3). PMID: 30760493    Free PMC article.
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells.
Jessica Bourque, Daniel Hawiger.
Crit Rev Immunol, 2019 Feb 23; 38(5). PMID: 30792568    Free PMC article.
Highly Cited. Review.
B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes.
Peter S Linsley, Carla J Greenbaum, +2 authors, Matthew J Dufort.
JCI Insight, 2019 Mar 05; 4(4). PMID: 30830871    Free PMC article.
Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions.
Jung-Chen Lin, Chen-Ying Chien, +9 authors, Che-Ming J Hu.
Nat Commun, 2019 Mar 07; 10(1). PMID: 30837473    Free PMC article.
Isolation of B-cells using Miltenyi MACS bead isolation kits.
Dannielle K Moore, Bongani Motaung, +3 authors, SU-IRG Consortium.
PLoS One, 2019 Mar 21; 14(3). PMID: 30893384    Free PMC article.
Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.
Yu Fujita, Roberto Tinoco, +2 authors, Ze'ev A Ronai.
Trends Mol Med, 2019 Mar 23; 25(5). PMID: 30898473    Free PMC article.
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Spencer C Wei, Roshan Sharma, +8 authors, James P Allison.
Immunity, 2019 Mar 31; 50(4). PMID: 30926234    Free PMC article.
Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity.
Rojan Shrestha, Sarah C Garrett, Steven C Almo, Andras Fiser.
Structure, 2019 Apr 02; 27(5). PMID: 30930066    Free PMC article.
CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis.
Hui Zhang, Ryu Watanabe, +3 authors, Cornelia M Weyand.
J Am Coll Cardiol, 2019 Apr 13; 73(14). PMID: 30975299    Free PMC article.
Weaponizing T-cell receptors through molecular engineering.
Elissa K Leonard, Michael I Leff, Jamie B Spangler.
J Biol Chem, 2019 Apr 14; 294(15). PMID: 30979848    Free PMC article.
Emerging therapies for non-small cell lung cancer.
Chao Zhang, Natasha B Leighl, Yi-Long Wu, Wen-Zhao Zhong.
J Hematol Oncol, 2019 Apr 27; 12(1). PMID: 31023335    Free PMC article.
Highly Cited. Review.
Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo.
Fadi Issa, Kate Milward, +3 authors, Joanna Hester.
Front Immunol, 2019 May 10; 10. PMID: 31068951    Free PMC article.
Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity.
Xinyue Qi, Fanlin Li, +4 authors, Xuanming Yang.
Nat Commun, 2019 May 21; 10(1). PMID: 31105267    Free PMC article.
Toxoplasma gondii: CD8 T Cells Cry for CD4 Help.
Imtiaz A Khan, SuJin Hwang, Magali Moretto.
Front Cell Infect Microbiol, 2019 May 24; 9. PMID: 31119107    Free PMC article.
Interaction of CD99 and its ligand upregulates IL-6 and TNF-α upon T cell activation.
Nuchjira Takheaw, Papawadee Earwong, +2 authors, Watchara Kasinrerk.
PLoS One, 2019 May 24; 14(5). PMID: 31120992    Free PMC article.
B7-CD28 gene family expression is associated with prognostic and immunological characteristics of diffuse large B-cell lymphoma.
Gangjian Wang, Xiaorui Fu, +7 authors, Mingzhi Zhang.
Aging (Albany NY), 2019 Jun 14; 11(12). PMID: 31195368    Free PMC article.
Immune precision medicine for cancer: a novel insight based on the efficiency of immune effector cells.
Jean-François Rossi, Patrice Céballos, Zhao-Yang Lu.
Cancer Commun (Lond), 2019 Jun 16; 39(1). PMID: 31200766    Free PMC article.
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance.
Günther Schönrich, Martin J Raftery.
Front Cell Infect Microbiol, 2019 Jul 03; 9. PMID: 31263684    Free PMC article.
Highly Cited. Review.
The Prognostic Landscape of Tumor-Infiltrating Immune Cells and Immune Checkpoints in Glioblastoma.
Shiman Wu, Wenli Yang, +4 authors, Zhenwei Yao.
Technol Cancer Res Treat, 2019 Aug 28; 18. PMID: 31451090    Free PMC article.
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
Matthew F Pech, Linda E Fong, +7 authors, Jeffrey Settleman.
Elife, 2019 Aug 28; 8. PMID: 31452512    Free PMC article.
Safety, Tolerability, and Potential Clinical Activity of a Glucocorticoid-Induced TNF Receptor-Related Protein Agonist Alone or in Combination With Nivolumab for Patients With Advanced Solid Tumors: A Phase 1/2a Dose-Escalation and Cohort-Expansion Clinical Trial.
Kimberley M Heinhuis, Matteo Carlino, +17 authors, Lillian L Siu.
JAMA Oncol, 2019 Nov 08; 6(1). PMID: 31697308    Free PMC article.
PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage.
Saravanan Raju, Daniel J Verbaro, Takeshi Egawa.
Cell Rep, 2019 Nov 28; 29(9). PMID: 31775026    Free PMC article.
Select sequencing of clonally expanded CD8+ T cells reveals limits to clonal expansion.
Huang Huang, Michael J Sikora, +5 authors, Lars M Steinmetz.
Proc Natl Acad Sci U S A, 2019 Apr 18; 116(18). PMID: 30992377    Free PMC article.
Mechanisms of Leukemia Immune Evasion and Their Role in Relapse After Haploidentical Hematopoietic Cell Transplantation.
Pier Edoardo Rovatti, Valentina Gambacorta, +2 authors, Luca Vago.
Front Immunol, 2020 Mar 12; 11. PMID: 32158444    Free PMC article.
Co-Stimulatory Receptors in Cancers and Their Implications for Cancer Immunotherapy.
Seongju Jeong, Su-Hyung Park.
Immune Netw, 2020 Mar 12; 20(1). PMID: 32158591    Free PMC article.
CAMPANELLIProgrammed Death 1 (PD-1) and PD-1 Ligand (PD-L1) Expression in Chronic Apical Periodontitis.
Ronan Jacques Rezende Delgado, Claudia Ramos Pinheiro, +10 authors, Ana Paula Campanelli.
Eur Endod J, 2020 Mar 13; 4(1). PMID: 32161879    Free PMC article.
Co-signaling receptors regulate T-cell plasticity and immune tolerance.
Haitao Shen, Na Wu, +16 authors, Xiaofeng Yang.
Front Biosci (Landmark Ed), 2018 Nov 24; 24(1). PMID: 30468648    Free PMC article.
Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions.
Francesca Arruga, Benjamin Baffour Gyau, +3 authors, Silvia Deaglio.
Int J Mol Sci, 2020 Mar 12; 21(5). PMID: 32155826    Free PMC article.
Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8+ T-cell activation and exhaustion.
José Belizário, Maria Fernanda Destro Rodrigues.
Ther Adv Vaccines Immunother, 2020 Mar 25; 8. PMID: 32206744    Free PMC article.
Immunotherapy of Melanoma: Facts and Hopes.
Sarah A Weiss, Jedd D Wolchok, Mario Sznol.
Clin Cancer Res, 2019 Mar 30; 25(17). PMID: 30923036    Free PMC article.
CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells.
Aida S Hansen, Josefine Slater, +3 authors, Per Höllsberg.
Immunol Lett, 2018 Jun 15; 200. PMID: 29902483    Free PMC article.
Phase II evaluation of nivolumab in the treatment of persistent or recurrent cervical cancer (NCT02257528/NRG-GY002).
Alessandro D Santin, Wei Deng, +9 authors, Michael Birrer.
Gynecol Oncol, 2020 Jan 12; 157(1). PMID: 31924334    Free PMC article.
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.
Alexandra Schnell, Lloyd Bod, Asaf Madi, Vijay K Kuchroo.
Cell Res, 2020 Jan 25; 30(4). PMID: 31974523    Free PMC article.
Increased attrition of memory T cells during sepsis requires 2B4.
Jianfeng Xie, Ching-Wen Chen, +6 authors, Mandy L Ford.
JCI Insight, 2019 May 03; 4(9). PMID: 31045575    Free PMC article.
Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae.
Romain Marlin, Marie-Thérèse Nugeyre, +12 authors, Elisabeth Menu.
Front Immunol, 2019 Mar 28; 10. PMID: 30915079    Free PMC article.
Combining Immune Checkpoint Inhibitors with Anti-Angiogenic Agents.
Paola Ciciola, Priscilla Cascetta, +2 authors, Roberto Bianco.
J Clin Med, 2020 Mar 07; 9(3). PMID: 32138216    Free PMC article.
Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease.
Govindarajan Thangavelu, Bruce R Blazar.
Front Immunol, 2019 Mar 25; 10. PMID: 30906290    Free PMC article.
Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence.
Raju K Vaddepally, Prakash Kharel, +2 authors, Abhinav B Chandra.
Cancers (Basel), 2020 Apr 05; 12(3). PMID: 32245016    Free PMC article.
4-1BB Delineates Distinct Activation Status of Exhausted Tumor-Infiltrating CD8+ T Cells in Hepatocellular Carcinoma.
Hyung-Don Kim, Seongyeol Park, +15 authors, Su-Hyung Park.
Hepatology, 2019 Jul 30; 71(3). PMID: 31353502    Free PMC article.
CD8+ T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity.
Roman V Uzhachenko, Anil Shanker.
Front Immunol, 2019 Aug 29; 10. PMID: 31456803    Free PMC article.
Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth.
Chenjun Bai, Shanshan Gao, +8 authors, Ningsheng Shao.
Mol Ther Oncolytics, 2020 Apr 14; 17. PMID: 32280743    Free PMC article.
Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.
Kanako Shimizu, Satoru Yamasaki, +8 authors, Shin-Ichiro Fujii.
Front Immunol, 2019 Jul 12; 10. PMID: 31293597    Free PMC article.
Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity.
Patricia Castro-Sánchez, Oscar Aguilar-Sopeña, +2 authors, Pedro Roda-Navarro.
Front Immunol, 2019 Jul 13; 10. PMID: 31297117    Free PMC article.
New Insights into Mechanisms of Long-term Protective Anti-tumor Immunity Induced by Cancer Vaccines Modified by Virus Infection.
Volker Schirrmacher.
Biomedicines, 2020 Mar 12; 8(3). PMID: 32155856    Free PMC article.
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
Jun Wang, Jingwei Sun, +16 authors, Lieping Chen.
Nat Med, 2019 Mar 06; 25(4). PMID: 30833750    Free PMC article.
Highly Cited.
Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation.
Michael D Powell, Kaitlin A Read, Bharath K Sreekumar, Kenneth J Oestreich.
Front Immunol, 2019 Jun 28; 10. PMID: 31244845    Free PMC article.
New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota.
Babita Agrawal.
Clin Transl Med, 2019 Aug 31; 8(1). PMID: 31468283    Free PMC article.
Resistance to PD-L1/PD-1 Blockade Immunotherapy. A Tumor-Intrinsic or Tumor-Extrinsic Phenomenon?
Luisa Chocarro de Erauso, Miren Zuazo, +8 authors, David Escors.
Front Pharmacol, 2020 Apr 23; 11. PMID: 32317979    Free PMC article.
Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition.
Qizhen Cao, Wanqin Wang, +13 authors, Chun Li.
Nanomedicine, 2020 Feb 16; 25. PMID: 32059873    Free PMC article.
Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression.
Chih-Hsien Cheng, Chen-Fang Lee, +4 authors, Jonathan D Powell.
Front Immunol, 2020 Apr 25; 11. PMID: 32328063    Free PMC article.
Mechanisms of Fetal T Cell Tolerance and Immune Regulation.
Elze Rackaityte, Joanna Halkias.
Front Immunol, 2020 Apr 25; 11. PMID: 32328065    Free PMC article.
Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives.
Stefania Raimondo, Marzia Pucci, Riccardo Alessandro, Simona Fontana.
Int J Mol Sci, 2020 Apr 01; 21(7). PMID: 32225076    Free PMC article.
The requirement for immune infiltration and organization in the tumor microenvironment for successful immunotherapy in prostate cancer.
Caroline S Jansen, Nataliya Prokhnevska, Haydn T Kissick.
Urol Oncol, 2018 Nov 18; 37(8). PMID: 30446449    Free PMC article.
EBV Latency III-Transformed B Cells Are Inducers of Conventional and Unconventional Regulatory T Cells in a PD-L1-Dependent Manner.
Héloïse Auclair, Catherine Ouk-Martin, +5 authors, Chantal Jayat-Vignoles.
J Immunol, 2019 Aug 23; 203(6). PMID: 31434708    Free PMC article.
HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality.
David M Richards, Viola Marschall, +10 authors, Meinolf Thiemann.
J Immunother Cancer, 2019 Jul 22; 7(1). PMID: 31324216    Free PMC article.
Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions.
Noriaki Yoshida, Kay Shigemori, +10 authors, David M Weinstock.
Blood, 2020 Jan 22; 135(17). PMID: 31961925    Free PMC article.
Targeting T cell activation in immuno-oncology.
S D Saibil, P S Ohashi.
Curr Oncol, 2020 May 06; 27(Suppl 2). PMID: 32368179    Free PMC article.
Redirection of Cord Blood T Cells and Natural Killer Cells for Elimination of Autologous HIV-1-Infected Target Cells Using Bispecific DART® Molecules.
Justin Pollara, R Whitney Edwards, +9 authors, Guido Ferrari.
Front Immunol, 2020 May 07; 11. PMID: 32373131    Free PMC article.
CDC27 Promotes Tumor Progression and Affects PD-L1 Expression in T-Cell Lymphoblastic Lymphoma.
Yue Song, Wei Song, +5 authors, Mingzhi Zhang.
Front Oncol, 2020 May 12; 10. PMID: 32391258    Free PMC article.
Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity.
Yuanyuan Xiao, Manish Muhuri, +20 authors, Guangping Gao.
JCI Insight, 2019 May 22; 5. PMID: 31112525    Free PMC article.
Genomics and Therapeutic Vulnerabilities of Primary Bone Tumors.
Katia Scotlandi, Claudia Maria Hattinger, +2 authors, Massimo Serra.
Cells, 2020 Apr 17; 9(4). PMID: 32295254    Free PMC article.
T cell immunotherapy enhanced by designer biomaterials.
Zachary S Dunn, John Mac, Pin Wang.
Biomaterials, 2019 Jul 05; 217. PMID: 31271861    Free PMC article.
An Integrative Network Modeling Approach to T CD4 Cell Activation.
David Martínez-Méndez, Carlos Villarreal, Luis Mendoza, Leonor Huerta.
Front Physiol, 2020 May 20; 11. PMID: 32425809    Free PMC article.
Talkin' Toxins: From Coley's to Modern Cancer Immunotherapy.
Robert D Carlson, John C Flickinger, Adam E Snook.
Toxins (Basel), 2020 Apr 15; 12(4). PMID: 32283684    Free PMC article.
Immunogenicity of Bioproducts: Cellular Models to Evaluate the Impact of Therapeutic Antibody Aggregates.
Myriam Nabhan, Marc Pallardy, Isabelle Turbica.
Front Immunol, 2020 May 21; 11. PMID: 32431697    Free PMC article.
Novel Developments in Primary Immunodeficiencies (PID)-a Rheumatological Perspective.
Helen Leavis, Jochen Zwerina, Bernhard Manger, Ruth D E Fritsch-Stork.
Curr Rheumatol Rep, 2019 Sep 06; 21(10). PMID: 31486986
Lattice Light-Sheet Microscopy Multi-dimensional Analyses (LaMDA) of T-Cell Receptor Dynamics Predict T-Cell Signaling States.
Jillian Rosenberg, Guoshuai Cao, Fernanda Borja-Prieto, Jun Huang.
Cell Syst, 2020 May 22; 10(5). PMID: 32437685    Free PMC article.
Engineering nanoparticles to reprogram radiotherapy and immunotherapy: recent advances and future challenges.
Jing Jin, Qijie Zhao.
J Nanobiotechnology, 2020 May 16; 18(1). PMID: 32408880    Free PMC article.
The emerging role of epigenetic therapeutics in immuno-oncology.
Michael J Topper, Michelle Vaz, +2 authors, Stephen B Baylin.
Nat Rev Clin Oncol, 2019 Sep 25; 17(2). PMID: 31548600    Free PMC article.
Identification of the cis‑molecular neighbours of the immune checkpoint protein B7‑H4 in the breast cancer cell‑line SK‑BR‑3 by proteomic proximity labelling.
Johanna S Rees, Lawrence C C Cheung, +5 authors, Antony P Jackson.
Int J Oncol, 2020 Apr 23; 57(1). PMID: 32319587    Free PMC article.
Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression.
Wei Wang, Nicole M Chapman, +7 authors, Zhao-Hui Wu.
Cancer Res, 2019 Feb 10; 79(11). PMID: 30737234    Free PMC article.
Vascular Endothelial Cells and Innate Immunity.
Ying Shao, Jason Saredy, +9 authors, Xiaofeng Yang.
Arterioscler Thromb Vasc Biol, 2020 May 28; 40(6). PMID: 32459541    Free PMC article.
Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report.
Brett R Martin, Gaurav Reshamwala, Melanie Short.
J Chiropr Med, 2019 Mar 09; 17(4). PMID: 30846920    Free PMC article.
Optimization of T-cell Receptor-Modified T Cells for Cancer Therapy.
Dylan J Drakes, Sarwish Rafiq, +4 authors, Renier J Brentjens.
Cancer Immunol Res, 2020 Mar 27; 8(6). PMID: 32209638    Free PMC article.
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity.
Linlin Sun, Chia-Wei Li, +17 authors, Mien-Chie Hung.
Cancer Res, 2020 Mar 12; 80(11). PMID: 32156778    Free PMC article.
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
Xiaozheng Xu, Bowen Hou, +10 authors, Enfu Hui.
J Cell Biol, 2020 May 22; 219(6). PMID: 32437509    Free PMC article.
Kaempferol and Its Glycoside, Kaempferol 7-O-Rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro.
Ji Hye Kim, Young Soo Kim, +5 authors, Hwan-Suck Chung.
Int J Mol Sci, 2020 May 08; 21(9). PMID: 32375257    Free PMC article.
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.
Norihisa Mikami, Ryoji Kawakami, +3 authors, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2020 May 18; 117(22). PMID: 32414925    Free PMC article.
The future of cancer immunotherapy: microenvironment-targeting combinations.
Yonina R Murciano-Goroff, Allison Betof Warner, Jedd D Wolchok.
Cell Res, 2020 May 30; 30(6). PMID: 32467593    Free PMC article.
Recent Advances: The Imbalance of Immune Cells and Cytokines in the Pathogenesis of Hepatocellular Carcinoma.
Kumar Jayant, Nagy Habib, +2 authors, Ramesh Arasaradnam.
Diagnostics (Basel), 2020 May 30; 10(5). PMID: 32466214    Free PMC article.
CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.
Gaëtan Blaize, Hélène Daniels-Treffandier, +13 authors, Renaud Lesourne.
Proc Natl Acad Sci U S A, 2020 May 22; 117(23). PMID: 32434911    Free PMC article.
Connexin-Mediated Signaling at the Immunological Synapse.
Andrés Tittarelli, Mariela Navarrete, +2 authors, Flavio Salazar-Onfray.
Int J Mol Sci, 2020 May 30; 21(10). PMID: 32466338    Free PMC article.
Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below the Signaling Threshold for Immune Response Genes.
Sarah L Bevington, Sky T H Ng, +3 authors, Peter N Cockerill.
Cell Rep, 2020 Jun 11; 31(10). PMID: 32521273    Free PMC article.
Novel biomanufacturing platform for large-scale and high-quality human T cells production.
Jianfa Ou, Yingnan Si, +6 authors, Xiaoguang Liu.
J Biol Eng, 2019 May 03; 13. PMID: 31044002    Free PMC article.
Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling.
Claire Y Ma, John C Marioni, Gillian M Griffiths, Arianne C Richard.
Elife, 2020 May 16; 9. PMID: 32412411    Free PMC article.
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy.
Daria S Chulpanova, Kristina V Kitaeva, +2 authors, Valeriya V Solovyeva.
Front Cell Dev Biol, 2020 Jun 26; 8. PMID: 32582698    Free PMC article.
Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo.
Gitte Holmen Olofsson, Agnete Witness Praest Jensen, Manja Idorn, Per Thor Straten.
Int J Mol Sci, 2020 May 31; 21(11). PMID: 32471301    Free PMC article.
Mouse Tumor Models for Advanced Cancer Immunotherapy.
Daria S Chulpanova, Kristina V Kitaeva, +2 authors, Valeriya V Solovyeva.
Int J Mol Sci, 2020 Jun 13; 21(11). PMID: 32526987    Free PMC article.
Immune Checkpoint Inhibitors in Hepatocellular Cancer: Current Understanding on Mechanisms of Resistance and Biomarkers of Response to Treatment.
Amblessed E Onuma, Hongji Zhang, +3 authors, Allan Tsung.
Gene Expr, 2020 Apr 29; 20(1). PMID: 32340652    Free PMC article.
CD3xCD19 DART molecule treatment induces non-apoptotic killing and is efficient against high-risk chemotherapy and venetoclax-resistant chronic lymphocytic leukemia cells.
Anne W J Martens, Susanne R Janssen, +7 authors, Arnon P Kater.
J Immunother Cancer, 2020 Jun 26; 8(1). PMID: 32581054    Free PMC article.
Cellular immunotherapies for cancer.
Conall Hayes.
Ir J Med Sci, 2020 Jul 02; 190(1). PMID: 32607912    Free PMC article.
Engineering and functionalization of large circular tandem repeat protein nanoparticles.
Colin E Correnti, Jazmine P Hallinan, +12 authors, Philip Bradley.
Nat Struct Mol Biol, 2020 Mar 24; 27(4). PMID: 32203491    Free PMC article.
Human cancer germline antigen-specific cytotoxic T cell-what can we learn from patient.
Megat Abd Hamid, Yanchun Peng, Tao Dong.
Cell Mol Immunol, 2020 May 27; 17(7). PMID: 32451453    Free PMC article.
Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions.
Xianhui Meng, Ruirui Jing, +2 authors, Jie Sun.
Front Immunol, 2020 Jul 09; 11. PMID: 32636832    Free PMC article.
Chimeric antigen receptor signaling: Functional consequences and design implications.
S E Lindner, S M Johnson, C E Brown, L D Wang.
Sci Adv, 2020 Jul 09; 6(21). PMID: 32637585    Free PMC article.
Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy.
Zineb Belcaid, Cor Berrevoets, +13 authors, Martine L M Lamfers.
Neurooncol Adv, 2020 Jul 10; 2(1). PMID: 32642679    Free PMC article.
Fighting Persistence: How Chronic Infections with Mycobacterium tuberculosis Evade T Cell-Mediated Clearance and New Strategies To Defeat Them.
Laurisa Ankley, Sean Thomas, Andrew J Olive.
Infect Immun, 2020 Feb 26; 88(7). PMID: 32094248    Free PMC article.
In vitro assays for effector T cell functions and activity of immunomodulatory antibodies.
Roberta Zappasodi, Sadna Budhu, Mohsen Abu-Akeel, Taha Merghoub.
Methods Enzymol, 2020 Jan 18; 631. PMID: 31948562    Free PMC article.
Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors.
Florent Peyraud, Antoine Italiano.
Cancers (Basel), 2020 Jun 13; 12(6). PMID: 32526888    Free PMC article.
CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses.
Di Wang, Juan Du, +9 authors, Yaxian Kong.
Aging (Albany NY), 2020 Jun 20; 12(12). PMID: 32559178    Free PMC article.
Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy.
Jan A Rath, Caroline Arber.
Cells, 2020 Jun 24; 9(6). PMID: 32570906    Free PMC article.
Producing Soluble Human Programmed Cell Death Protein-1: A Natural Supporter for CD4+T Cell Cytotoxicity and Tumor Cells Apoptosis.
Samane Mohammadzadeh, Hossein Khanahmad, +4 authors, Alireza Andalib.
Iran J Biotechnol, 2020 Jul 17; 17(4). PMID: 32671122    Free PMC article.
IFN-γ: A cytokine at the right time, is in the right place.
J Daniel Burke, Howard A Young.
Semin Immunol, 2019 Jun 22; 43. PMID: 31221552    Free PMC article.
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma.
Grégory Seumois, Ciro Ramírez-Suástegui, +4 authors, Pandurangan Vijayanand.
Sci Immunol, 2020 Jun 14; 5(48). PMID: 32532832    Free PMC article.
Integrating the Tumor Microenvironment into Cancer Therapy.
Sabina Sanegre, Federico Lucantoni, +3 authors, Tomás Álvaro Naranjo.
Cancers (Basel), 2020 Jul 01; 12(6). PMID: 32599891    Free PMC article.
Recombinant Costimulatory Fusion Proteins as Functional Immunomodulators Enhance Antitumor Activity in Murine B16F10 Melanoma.
Huaman Cai, Wenfang Wang, +4 authors, Rongxiu Li.
Vaccines (Basel), 2020 May 20; 8(2). PMID: 32423130    Free PMC article.
Immune Checkpoint Inhibitors: A Promising Choice for Endometrial Cancer Patients?
Lucia Musacchio, Serena Maria Boccia, +9 authors, Violante Di Donato.
J Clin Med, 2020 Jun 07; 9(6). PMID: 32503218    Free PMC article.
The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection.
Kristen E Pauken, Jernej Godec, +13 authors, Arlene H Sharpe.
Cell Rep, 2020 Jul 02; 31(13). PMID: 32610128    Free PMC article.
M2b macrophage polarization and its roles in diseases.
Le-Xun Wang, Sheng-Xi Zhang, +2 authors, Jiao Guo.
J Leukoc Biol, 2018 Dec 24; 106(2). PMID: 30576000    Free PMC article.
Highly Cited. Review.
Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma.
Joanne L Tuohy, Jason A Somarelli, +3 authors, Jonathan E Fogle.
Vet Comp Oncol, 2019 Aug 20; 18(1). PMID: 31420936    Free PMC article.
Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis.
Wei Yang, Sara A Gibson, +5 authors, Etty N Benveniste.
Mucosal Immunol, 2020 Jan 29; 13(5). PMID: 31988467    Free PMC article.
Multivalent Soluble Antigen Arrays Exhibit High Avidity Binding and Modulation of B Cell Receptor-Mediated Signaling to Drive Efficacy against Experimental Autoimmune Encephalomyelitis.
Brittany L Hartwell, Chad J Pickens, Martin Leon, Cory Berkland.
Biomacromolecules, 2017 May 06; 18(6). PMID: 28474886    Free PMC article.
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
Mohamed A ElTanbouly, Yanding Zhao, +19 authors, Randolph J Noelle.
Science, 2020 Jan 18; 367(6475). PMID: 31949051    Free PMC article.
Cytokines and costimulation in acute graft-versus-host disease.
Geoffrey R Hill, Motoko Koyama.
Blood, 2020 Jun 12; 136(4). PMID: 32526028    Free PMC article.
Efficacy and Safety of CD28- or 4-1BB-Based CD19 CAR-T Cells in B Cell Acute Lymphoblastic Leukemia.
Xiangyu Zhao, Junfang Yang, +11 authors, Xiaojun Huang.
Mol Ther Oncolytics, 2020 Jul 31; 18. PMID: 32728615    Free PMC article.
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.
Andrew L Ji, Adam J Rubin, +18 authors, Paul A Khavari.
Cell, 2020 Jun 25; 182(2). PMID: 32579974    Free PMC article.
Network Approaches for Dissecting the Immune System.
Hao Shi, Koon-Kiu Yan, +3 authors, Jiyang Yu.
iScience, 2020 Jul 28; 23(8). PMID: 32717640    Free PMC article.
Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10.
Shan-Shan Yin, Feng-Hou Gao.
Front Immunol, 2020 Aug 09; 11. PMID: 32765491    Free PMC article.
The Latest Findings of PD-1/PD-L1 Inhibitor Application in Gynecologic Cancers.
Omid Kooshkaki, Afshin Derakhshani, +9 authors, Behzad Baradaran.
Int J Mol Sci, 2020 Jul 28; 21(14). PMID: 32708748    Free PMC article.
Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity.
Alexandra Borodovsky, Christine M Barbon, +21 authors, Deanna A Mele.
J Immunother Cancer, 2020 Jul 31; 8(2). PMID: 32727810    Free PMC article.
The Immune Profile of Pituitary Adenomas and a Novel Immune Classification for Predicting Immunotherapy Responsiveness.
Zihao Wang, Xiaopeng Guo, +7 authors, Bing Xing.
J Clin Endocrinol Metab, 2020 Jul 12; 105(9). PMID: 32652004    Free PMC article.
CD38: T Cell Immuno-Metabolic Modulator.
Anwesha Kar, Shikhar Mehrotra, Shilpak Chatterjee.
Cells, 2020 Jul 28; 9(7). PMID: 32709019    Free PMC article.
CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells.
Marion Alcantara, Melania Tesio, Carl H June, Roch Houot.
Leukemia, 2018 Oct 14; 32(11). PMID: 30315238    Free PMC article.
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications.
Yuanyuan Zhang, Zemin Zhang.
Cell Mol Immunol, 2020 Jul 03; 17(8). PMID: 32612154    Free PMC article.
Metabolic signaling in T cells.
Justin A Shyer, Richard A Flavell, Will Bailis.
Cell Res, 2020 Jul 28; 30(8). PMID: 32709897    Free PMC article.
Targeting PD-L1 in non-small cell lung cancer using CAR T cells.
Ming Liu, Xu Wang, +8 authors, Yong Li.
Oncogenesis, 2020 Aug 15; 9(8). PMID: 32792499    Free PMC article.
Melanoma brain metastases: review of histopathological features and immune-molecular aspects.
Lorenzo Salvati, Mario Mandalà, Daniela Massi.
Melanoma Manag, 2020 Aug 22; 7(2). PMID: 32821376    Free PMC article.
Differential quantities of immune checkpoint-expressing CD8 T cells in soft tissue sarcoma subtypes.
Yarne Klaver, Maud Rijnders, +7 authors, Reno Debets.
J Immunother Cancer, 2020 Aug 15; 8(2). PMID: 32792357    Free PMC article.
Reactive Oxygen Species and Antitumor Immunity-From Surveillance to Evasion.
Andromachi Kotsafti, Marco Scarpa, Ignazio Castagliuolo, Melania Scarpa.
Cancers (Basel), 2020 Jul 08; 12(7). PMID: 32630174    Free PMC article.
MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy.
Milad Ashrafizadeh, Hui Li Ang, +8 authors, Alan Prem Kumar.
Biomolecules, 2020 Jul 16; 10(7). PMID: 32664703    Free PMC article.
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy.
Lukas Amon, Lukas Hatscher, +2 authors, Christian H K Lehmann.
Pharmaceutics, 2020 Jul 18; 12(7). PMID: 32674488    Free PMC article.
Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD.
Eleonora Latis, David Michonneau, +6 authors, Lars Rogge.
Blood Adv, 2020 Aug 21; 4(16). PMID: 32818226    Free PMC article.
Disease Stage-Specific Pathogenicity of CD138 (Syndecan 1)-Expressing T Cells in Systemic Lupus Erythematosus.
Lunhua Liu, Kazuyo Takeda, Mustafa Akkoyunlu.
Front Immunol, 2020 Aug 28; 11. PMID: 32849532    Free PMC article.
The Role of GSK3β in T Lymphocytes in the Tumor Microenvironment.
Anastasios Dimou, Konstantinos N Syrigos.
Front Oncol, 2020 Aug 28; 10. PMID: 32850361    Free PMC article.
T Cell Membrane Heterogeneity Aids Antigen Recognition and T Cell Activation.
Megan V Farrell, Samantha Webster, Katharina Gaus, Jesse Goyette.
Front Cell Dev Biol, 2020 Aug 28; 8. PMID: 32850786    Free PMC article.
Rational design of anti-GITR-based combination immunotherapy.
Roberta Zappasodi, Cynthia Sirard, +16 authors, Taha Merghoub.
Nat Med, 2019 May 01; 25(5). PMID: 31036879    Free PMC article.
Highly Cited.
Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy.
Fei Yi, Nicholas Frazzette, +2 authors, Richard M Siegel.
Trends Mol Med, 2018 Jun 09; 24(7). PMID: 29880309    Free PMC article.
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance.
Vivek Verma, Rajeev K Shrimali, +25 authors, Samir N Khleif.
Nat Immunol, 2019 Jul 31; 20(9). PMID: 31358999    Free PMC article.
Highly Cited.
Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family.
Pablo Martínez-Vicente, Domènec Farré, Pablo Engel, Ana Angulo.
Viruses, 2020 Aug 01; 12(8). PMID: 32731344    Free PMC article.
Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor-engineered T Cells.
Esther Drent, Renée Poels, +9 authors, Maria Themeli.
Clin Cancer Res, 2019 Apr 14; 25(13). PMID: 30979735    Free PMC article.
Highly Cited.
Combinatorial approach to cancer immunotherapy: strength in numbers.
Anna E Vilgelm, Douglas B Johnson, Ann Richmond.
J Leukoc Biol, 2016 Jun 04; 100(2). PMID: 27256570    Free PMC article.
Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide.
Ben Niu, Todd C Appleby, +11 authors, Michael L Gross.
Biochemistry, 2019 Dec 17; 59(4). PMID: 31841311    Free PMC article.
Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses.
Enas Abu-Shah, Nicola Trendel, +4 authors, Omer Dushek.
J Immunol, 2020 Aug 21; 205(6). PMID: 32817332    Free PMC article.
IκBα Nuclear Export Enables 4-1BB-Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity.
Dominique N Lisiero, Zhang Cheng, +6 authors, Shigeki Miyamoto.
J Immunol, 2020 Aug 21; 205(6). PMID: 32817348    Free PMC article.
Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings.
Mounika U L Goruganthu, Anil Shanker, Mikhail M Dikov, David P Carbone.
Front Immunol, 2020 Sep 15; 11. PMID: 32922403    Free PMC article.
Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model.
Xuan Ye, Janelle C Waite, +12 authors, Dimitris Skokos.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923116    Free PMC article.
Age-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancer.
Hao Chen, Wei Chong, +4 authors, Ming Lu.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923150    Free PMC article.
Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells.
Jan A Rath, Gagan Bajwa, +15 authors, Caroline Arber.
Sci Adv, 2020 Sep 15; 6(27). PMID: 32923584    Free PMC article.
Biomarkers of immunotherapy in non-small cell lung cancer.
Lingling Wang, Yue Hu, +2 authors, Xiaochen Wang.
Oncol Lett, 2020 Sep 17; 20(5). PMID: 32934707    Free PMC article.
Immunotherapy in urothelial cancer, part 1: T-cell checkpoint inhibition in advanced or metastatic disease.
Steven S Yu, Tanya B Dorff, +3 authors, David I Quinn.
Clin Adv Hematol Oncol, 2017 Jul 28; 15(6). PMID: 28749907    Free PMC article.
B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells.
Weiwei Yu, Ling Chen, +2 authors, Lieping Chen.
Oncoimmunology, 2018 Dec 24; 7(11). PMID: 30574431    Free PMC article.
Immunophenotypic characterization of sphere-forming cells derived from the human renal cell carcinoma cell line 786-O.
Chanjuan Shen, Guoyu Hu, +4 authors, Yong Zhong.
Am J Transl Res, 2019 Jan 22; 10(12). PMID: 30662644    Free PMC article.
Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor.
Ryosuke Uchibori, Takeshi Teruya, +6 authors, Keiya Ozawa.
Mol Ther Oncolytics, 2019 Jan 22; 12. PMID: 30662937    Free PMC article.
Interaction between a 3D collagen matrix used for periodontal soft tissue regeneration and T-lymphocytes: An in vitro pilot study.
Darian Rusu, Marius Boariu, +10 authors, Bogdan Calenic.
Exp Ther Med, 2019 Jan 27; 17(2). PMID: 30679964    Free PMC article.
Treatment Combining CD200 Immune Checkpoint Inhibitor and Tumor-Lysate Vaccination after Surgery for Pet Dogs with High-Grade Glioma.
Michael R Olin, Elisabet Ampudia-Mesias, +5 authors, G Elizabeth Pluhar.
Cancers (Basel), 2019 Jan 27; 11(2). PMID: 30682795    Free PMC article.
Adaptive Immune Responses Contribute to Post-ischemic Cardiac Remodeling.
Icia Santos-Zas, Jérémie Lemarié, Alain Tedgui, Hafid Ait-Oufella.
Front Cardiovasc Med, 2019 Jan 29; 5. PMID: 30687720    Free PMC article.
Heart failure in cancer: role of checkpoint inhibitors.
Murilo Delgobo, Stefan Frantz.
J Thorac Dis, 2019 Feb 01; 10(Suppl 35). PMID: 30701100    Free PMC article.
Genomic and transcriptional Profiling of tumor infiltrated CD8+ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma.
Zhenli Li, Geng Chen, +6 authors, Jingfeng Liu.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713796    Free PMC article.
Cardiac Complications in Immune Checkpoint Inhibition Therapy.
Kazuko Tajiri, Masaki Ieda.
Front Cardiovasc Med, 2019 Feb 08; 6. PMID: 30729114    Free PMC article.
Chimeric Antigen Receptor T Cell Therapy for Solid Tumors: Current Status, Obstacles and Future Strategies.
Benjamin Heyman, Yiping Yang.
Cancers (Basel), 2019 Feb 10; 11(2). PMID: 30736355    Free PMC article.
Membrane PD-L1 expression and soluble PD-L1 plasma levels in idiopathic pulmonary fibrosis-a pilot study.
Dragana Jovanovic, Marina Roksandic Milenkovic, +4 authors, Vesna Skodric Trifunovic.
J Thorac Dis, 2019 Feb 13; 10(12). PMID: 30746211    Free PMC article.
The evolving role of immuno-oncology for the treatment of head and neck cancer.
Arianna L Strome, Xiaoyu Zhang, Scott E Strome.
Laryngoscope Investig Otolaryngol, 2019 Mar 05; 4(1). PMID: 30828620    Free PMC article.
Immunotherapy Associated Pulmonary Toxicity: Biology Behind Clinical and Radiological Features.
Michele Porcu, Pushpamali De Silva, +8 authors, Luca Saba.
Cancers (Basel), 2019 Mar 08; 11(3). PMID: 30841554    Free PMC article.
Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System.
Shweta Joshi, Donald L Durden.
J Oncol, 2019 Mar 12; 2019. PMID: 30853982    Free PMC article.
Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment.
Guyu Zhang, Chongdong Liu, +3 authors, Zhengyu Zhang.
Oncol Lett, 2019 Mar 12; 17(3). PMID: 30854033    Free PMC article.
Emerging Nano-/Microapproaches for Cancer Immunotherapy.
Yu Mi, C Tilden Hagan, Benjamin G Vincent, Andrew Z Wang.
Adv Sci (Weinh), 2019 Apr 03; 6(6). PMID: 30937265    Free PMC article.
Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms.
Arsalan Alizadeh, Scott Matthew Dyck, Soheila Karimi-Abdolrezaee.
Front Neurol, 2019 Apr 11; 10. PMID: 30967837    Free PMC article.
Highly Cited. Review.
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade.
Mingxia Zhao, Wenjie Guo, +11 authors, Yang Sun.
Acta Pharm Sin B, 2019 Apr 12; 9(2). PMID: 30972278    Free PMC article.
Highly Cited.
Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy.
Madison Canning, Gang Guo, +4 authors, Yan Cui.
Front Cell Dev Biol, 2019 Apr 27; 7. PMID: 31024913    Free PMC article.
Highly Cited. Review.
Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations.
Robert Weinkove, Philip George, Nathaniel Dasyam, Alexander D McLellan.
Clin Transl Immunology, 2019 May 22; 8(5). PMID: 31110702    Free PMC article.
Highly Cited. Review.
CD8+ PD-1+ T-cells and PD-L1+ circulating tumor cells in chemotherapy-naïve non-small cell lung cancer: towards their clinical relevance?
Athanasios Kotsakis, Galatea Kallergi, +6 authors, Eleni-Kyriaki Vetsika.
Ther Adv Med Oncol, 2019 Jun 21; 11. PMID: 31217824    Free PMC article.
CD8+ T Cells Protect During Vein Graft Disease Development.
Karin H Simons, Margreet R de Vries, +3 authors, Ramon Arens.
Front Cardiovasc Med, 2019 Jul 03; 6. PMID: 31263704    Free PMC article.
Clinical Scenarios Emerging from Combined Immunophenotypic, Molecular and Morphologic Analysis of Pancreatic Cancer: The Good, the Bad and the Ugly Scenario.
Eva Karamitopoulou, Beat Gloor.
Cancers (Basel), 2019 Jul 13; 11(7). PMID: 31295960    Free PMC article.
Aptamedicine: a new treatment modality in personalized cancer therapy.
Somayeh Vandghanooni, Morteza Eskandani, Jaleh Barar, Yadollah Omidi.
Bioimpacts, 2019 Jul 25; 9(2). PMID: 31334037    Free PMC article.
AP-1 Transcription Factors as Regulators of Immune Responses in Cancer.
Vasileios Atsaves, Vasiliki Leventaki, George Z Rassidakis, Francois X Claret.
Cancers (Basel), 2019 Jul 26; 11(7). PMID: 31340499    Free PMC article.
Immune checkpoint inhibitors for small cell lung cancer: opportunities and challenges.
Orgilmaa Regzedmaa, Hongbing Zhang, Hongyu Liu, Jun Chen.
Onco Targets Ther, 2019 Jul 30; 12. PMID: 31354294    Free PMC article.
High Level Expression of MHC-II in HPV+ Head and Neck Cancers Suggests that Tumor Epithelial Cells Serve an Important Role as Accessory Antigen Presenting Cells.
Steven F Gameiro, Farhad Ghasemi, +2 authors, Joe S Mymryk.
Cancers (Basel), 2019 Aug 10; 11(8). PMID: 31394808    Free PMC article.
A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity.
Nadine Nelson, Marta Lopez-Pelaez, +7 authors, Paul D Smith.
Oncoimmunology, 2019 Aug 16; 8(8). PMID: 31413906    Free PMC article.
Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.
Erin Naismith, Luca Pangrazzi, +5 authors, Beatrix Grubeck-Loebenstein.
Immun Ageing, 2019 Aug 30; 16. PMID: 31462901    Free PMC article.
Taking up Cancer Immunotherapy Challenges: Bispecific Antibodies, the Path Forward?
Joanie Del Bano, Patrick Chames, Daniel Baty, Brigitte Kerfelec.
Antibodies (Basel), 2015 Dec 26; 5(1). PMID: 31557983    Free PMC article.
Immunotherapy in urothelial cancer, part 2: adjuvant, neoadjuvant, and adjunctive treatment.
Steven S Yu, Leslie K Ballas, +3 authors, David I Quinn.
Clin Adv Hematol Oncol, 2017 Jul 28; 15(7). PMID: 28749918    Free PMC article.
Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review.
Yolla Haibe, Ziad El Husseini, Rola El Sayed, Ali Shamseddine.
Int J Mol Sci, 2020 Sep 02; 21(17). PMID: 32867025    Free PMC article.
Systematic Review.
High MHC-II expression in Epstein-Barr virus-associated gastric cancers suggests that tumor cells serve an important role in antigen presentation.
Farhad Ghasemi, Tanner M Tessier, +3 authors, Joe S Mymryk.
Sci Rep, 2020 Sep 10; 10(1). PMID: 32901107    Free PMC article.
Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies.
Ting Zhou, Tina Tianjiao Su, Tenny Mudianto, Jun Wang.
J Exp Med, 2020 Sep 11; 217(10). PMID: 32910820    Free PMC article.
Modulation of Cell Surface Receptor Expression by Modified Vaccinia Virus Ankara in Leukocytes of Healthy and HIV-Infected Individuals.
Adrien Leite Pereira, Quentin Jouhault, +5 authors, Nicolas Tchitchek.
Front Immunol, 2020 Oct 06; 11. PMID: 33013882    Free PMC article.
Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials.
Haiying Lu, Qiaodan Zhou, +4 authors, Jianyou Shi.
Signal Transduct Target Ther, 2020 Sep 25; 5(1). PMID: 32968059    Free PMC article.
T-cell agonists in cancer immunotherapy.
Yeonjoo Choi, Yaoyao Shi, +3 authors, Joud Hajjar.
J Immunother Cancer, 2020 Oct 07; 8(2). PMID: 33020242    Free PMC article.
Evaluating Distribution and Prognostic Value of New Tumor-Infiltrating Lymphocytes in HCC Based on a scRNA-Seq Study With CIBERSORTx.
Lixing Li, Lu Shen, +8 authors, Tonghai Xing.
Front Med (Lausanne), 2020 Oct 13; 7. PMID: 33043022    Free PMC article.
Interferon-gamma-activated macrophages infected with Burkholderia cenocepacia process and present bacterial antigens to T-cells by class I and II major histocompatibility complex molecules.
Roberto Rosales-Reyes, Paola Garza-Villafuerte, +8 authors, José Ignacio Santos-Preciado.
Emerg Microbes Infect, 2020 Sep 03; 9(1). PMID: 32873215    Free PMC article.
Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response.
Sabrina Sapski, Nadine Beha, Roland E Kontermann, Dafne Müller.
Cancer Immunol Immunother, 2020 Jun 07; 69(11). PMID: 32504247    Free PMC article.
Annexin A5 is essential for PKCθ translocation during T-cell activation.
Zhaoqing Hu, Lin Li, +8 authors, Zichun Hua.
J Biol Chem, 2020 Aug 17; 295(41). PMID: 32796034    Free PMC article.
Adenovirus Receptor Expression in Cancer and Its Multifaceted Role in Oncolytic Adenovirus Therapy.
Lobke C M Hensen, Rob C Hoeben, Selas T F Bots.
Int J Mol Sci, 2020 Sep 23; 21(18). PMID: 32957644    Free PMC article.
Clinical Implications of Aberrant PD-1 and CTLA4 Expression for Cancer Immunity and Prognosis: A Pan-Cancer Study.
Jian-Nan Liu, Xiang-Shuo Kong, +3 authors, Qi-Feng Chen.
Front Immunol, 2020 Oct 20; 11. PMID: 33072070    Free PMC article.
Cellular Signaling Pathways in Medium and Large Vessel Vasculitis.
Ryu Watanabe, Gerald J Berry, +2 authors, Cornelia M Weyand.
Front Immunol, 2020 Oct 20; 11. PMID: 33072134    Free PMC article.
Innate-adaptive immunity interplay and redox regulation in immune response.
Lizhe Sun, Xianwei Wang, +3 authors, Hong Wang.
Redox Biol, 2020 Oct 22; 37. PMID: 33086106    Free PMC article.
Cellular and Molecular Mechanisms of CD8+ T Cell Differentiation, Dysfunction and Exhaustion.
Daniel J Verdon, Matthias Mulazzani, Misty R Jenkins.
Int J Mol Sci, 2020 Oct 09; 21(19). PMID: 33027962    Free PMC article.
T Cell Activation Machinery: Form and Function in Natural and Engineered Immune Receptors.
Nicholas J Chandler, Melissa J Call, Matthew E Call.
Int J Mol Sci, 2020 Oct 15; 21(19). PMID: 33050044    Free PMC article.
Platelet Induced Functional Alteration of CD4+ and CD8+ T Cells in HNSCC.
Christina Polasky, Franziska Wendt, Ralph Pries, Barbara Wollenberg.
Int J Mol Sci, 2020 Oct 16; 21(20). PMID: 33053760    Free PMC article.
Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms.
Anam Anjum, Muhammad Da'in Yazid, +6 authors, Yogeswaran Lokanathan.
Int J Mol Sci, 2020 Oct 18; 21(20). PMID: 33066029    Free PMC article.
Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels.
Andrés Tittarelli, Mariela Navarrete, +2 authors, Flavio Salazar-Onfray.
Int J Mol Sci, 2020 Oct 18; 21(20). PMID: 33066331    Free PMC article.
High-fat diet-induced obesity affects alpha 7 nicotine acetylcholine receptor expressions in mouse lung myeloid cells.
Yong Qi, Dan Si, +4 authors, Yunlei Yang.
Sci Rep, 2020 Oct 29; 10(1). PMID: 33110180    Free PMC article.
A Comprehensive Review of Biological Agents for Lupus: Beyond Single Target.
Bingyi Yang, Ming Zhao, Haijing Wu, Qianjin Lu.
Front Immunol, 2020 Oct 31; 11. PMID: 33123125    Free PMC article.
Systematic Review.
Immunotherapy for Hepatocellular Carcinoma: A 2021 Update.
Christo Kole, Nikolaos Charalampakis, +6 authors, Dimitrios Schizas.
Cancers (Basel), 2020 Oct 07; 12(10). PMID: 33020428    Free PMC article.
Reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly.
Xianwen Ren, Guojie Zhong, +3 authors, Zemin Zhang.
Cell Res, 2020 Jun 17; 30(9). PMID: 32541867    Free PMC article.
A DNA-Launched Nanoparticle Vaccine Elicits CD8+ T-cell Immunity to Promote In Vivo Tumor Control.
Ziyang Xu, Neethu Chokkalingam, +10 authors, David B Weiner.
Cancer Immunol Res, 2020 Sep 12; 8(11). PMID: 32913042    Free PMC article.
The tumor immune microenvironment transcriptomic subtypes of colorectal cancer for prognosis and development of precise immunotherapy.
Yun-Qiang Tang, Tu-Feng Chen, +8 authors, Jun Huang.
Gastroenterol Rep (Oxf), 2020 Nov 10; 8(5). PMID: 33163194    Free PMC article.
Zeb1 expression by tumor or stromal cells is associated with spatial distribution patterns of CD8+ tumor-infiltrating lymphocytes: a hypothesis-generating study on 113 triple negative breast cancers.
Mona Ouled Dhaou, Myriam Kossai, +4 authors, Nina Radosevic-Robin.
Am J Cancer Res, 2020 Nov 10; 10(10). PMID: 33163276    Free PMC article.
Dual Effect of Soloxolone Methyl on LPS-Induced Inflammation In Vitro and In Vivo.
Andrey V Markov, Aleksandra V Sen'kova, +6 authors, Evgeniya B Logashenko.
Int J Mol Sci, 2020 Oct 30; 21(21). PMID: 33114200    Free PMC article.
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies.
Kaijian Zhou, Shu Guo, +2 authors, Guoxin Liang.
Front Cell Dev Biol, 2020 Nov 13; 8. PMID: 33178688    Free PMC article.
Immunotherapy in Hematologic Malignancies: Emerging Therapies and Novel Approaches.
Ji-Yoon Noh, Huiyun Seo, Jungwoon Lee, Haiyoung Jung.
Int J Mol Sci, 2020 Oct 31; 21(21). PMID: 33121189    Free PMC article.
Updates in lymph node and skin pathology of adult T-cell leukemia/lymphoma, biomarkers, and beyond.
Brian D Adkins, Juan C Ramos, Meghan Bliss-Moreau, Alejandro A Gru.
Semin Diagn Pathol, 2020 Jan 01; 37(1). PMID: 31889601    Free PMC article.
Following in the footsteps of acute myeloid leukemia: are we witnessing the start of a therapeutic revolution for higher-risk myelodysplastic syndromes?
Jan Philipp Bewersdorf, Amer M Zeidan.
Leuk Lymphoma, 2020 May 19; 61(10). PMID: 32421403    Free PMC article.
Tumor necrosis family receptor superfamily member 9/tumor necrosis factor receptor-associated factor 1 pathway on hepatitis C viral persistence and natural history.
Julia Peña-Asensio, Eduardo Sanz-de-Villalobos, Joaquín Miquel, Juan Ramón Larrubia.
World J Hepatol, 2020 Nov 18; 12(10). PMID: 33200014    Free PMC article.
The synergism of B and T lymphocyte attenuator (BTLA) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) attenuated acute T-cell mediated rejection and prolonged renal graft survival.
Hengcheng Zhang, Zijie Wang, +6 authors, Min Gu.
Transl Androl Urol, 2020 Nov 20; 9(5). PMID: 33209663    Free PMC article.
Differences and similarities between cancer and somatic stem cells: therapeutic implications.
Fiorella Rossi, Hunter Noren, +2 authors, Karl-Henrik Grinnemo.
Stem Cell Res Ther, 2020 Nov 20; 11(1). PMID: 33208173    Free PMC article.
Emerging treatment options for patients with high-risk myelodysplastic syndrome.
Jan Philipp Bewersdorf, Hetty Carraway, Thomas Prebet.
Ther Adv Hematol, 2020 Nov 27; 11. PMID: 33240476    Free PMC article.
The Multifaceted Output of c-Jun Biological Activity: Focus at the Junction of CD8 T Cell Activation and Exhaustion.
Athanasios G Papavassiliou, Anna Maria Musti.
Cells, 2020 Nov 19; 9(11). PMID: 33202877    Free PMC article.
Unraveling the Mechanobiology of the Immune System.
Jeong-Ki Kim, Yu Jung Shin, +2 authors, Dong-Hwee Kim.
Adv Healthc Mater, 2019 Jan 08; 8(4). PMID: 30614636    Free PMC article.
Co-inhibitory Receptor Signaling in T-Cell-Mediated Autoimmune Glomerulonephritis.
Kei Nagai.
Front Med (Lausanne), 2020 Dec 01; 7. PMID: 33251233    Free PMC article.
Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors.
Rushikesh Sable, Seetharama Jois.
Molecules, 2015 Jun 26; 20(6). PMID: 26111183    Free PMC article.
MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus.
Barry Garchow, Marianthi Kiriakidou.
Clin Immunol, 2015 Dec 04; 162. PMID: 26631756    Free PMC article.
At the Bench: Chimeric antigen receptor (CAR) T cell therapy for the treatment of B cell malignancies.
Anthony F O Daniyan, Renier J Brentjens.
J Leukoc Biol, 2016 Oct 30; 100(6). PMID: 27789538    Free PMC article.
The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease.
Cornelia M Weyand, Gerald J Berry, Jörg J Goronzy.
J Leukoc Biol, 2017 Aug 30; 103(3). PMID: 28848042    Free PMC article.
Recent Progress in the Understanding of Angioimmunoblastic T-cell Lymphoma.
Manabu Fujisawa, Shigeru Chiba, Mamiko Sakata-Yanagimoto.
J Clin Exp Hematop, 2017 Dec 28; 57(3). PMID: 29279549    Free PMC article.
SLE-Associated Defects Promote Altered T Cell Function.
Jose C Crispin, Christian M Hedrich, +2 authors, George C Tsokos.
Crit Rev Immunol, 2018 Feb 13; 37(1). PMID: 29431078    Free PMC article.
Comparison of Efficacy of Pembrolizumab between Epstein-Barr Virus‒Positive and ‒Negative Relapsed or Refractory Non-Hodgkin Lymphomas.
Seok-Jin Kim, Jiyeon Hyeon, +2 authors, Won Seog Kim.
Cancer Res Treat, 2018 Jul 22; 51(2). PMID: 30025443    Free PMC article.
Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma.
Noam Auslander, Gao Zhang, +11 authors, Eytan Ruppin.
Nat Med, 2018 Aug 22; 24(10). PMID: 30127394    Free PMC article.
Highly Cited.
Mechanisms of Resistance to Immune Checkpoint Blockade.
David Liu, Russell W Jenkins, Ryan J Sullivan.
Am J Clin Dermatol, 2018 Sep 28; 20(1). PMID: 30259383    Free PMC article.
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization.
Miguel F Sanmamed, Lieping Chen.
Cell, 2018 Oct 06; 175(2). PMID: 30290139    Free PMC article.
Highly Cited. Review.
Combining Radiotherapy and Immunotherapy in Lung Cancer: Can We Expect Limitations Due to Altered Normal Tissue Toxicity?
Florian Wirsdörfer, Simone de Leve, Verena Jendrossek.
Int J Mol Sci, 2018 Dec 24; 20(1). PMID: 30577587    Free PMC article.
Alterations of the Immunologic Co-Stimulator B7 and TNFR Families Correlate with Hepatocellular Carcinoma Prognosis and Metastasis by Inactivating STAT3.
Yi-Ming Li, Zhen-Yu Liu, +5 authors, Juan Tang.
Int J Mol Sci, 2019 Jan 06; 20(1). PMID: 30609841    Free PMC article.
The role of immunotherapy in small cell lung cancer.
A Calles, G Aguado, C Sandoval, R Álvarez.
Clin Transl Oncol, 2019 Jan 15; 21(8). PMID: 30637710
STAT1 deficiency supports PD-1/PD-L1 signaling resulting in dysfunctional TNFα mediated immune responses in a model of NSCLC.
Juliane Friedrich, Lisanne Heim, +4 authors, Susetta Finotto.
Oncotarget, 2019 Jan 17; 9(98). PMID: 30647851    Free PMC article.
The growing role of precision and personalized medicine for cancer treatment.
Paulina Krzyszczyk, Alison Acevedo, +13 authors, Martin L Yarmush.
Technology (Singap World Sci), 2019 Feb 05; 6(3-4). PMID: 30713991    Free PMC article.
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives.
Yumeng Wang, Guiling Li.
Front Med, 2019 Mar 04; 13(4). PMID: 30826965
Understanding Immune Evasion and Therapeutic Targeting Associated with PD-1/PD-L1 Pathway in Diffuse Large B-cell Lymphoma.
Moo-Kon Song, Byeong-Bae Park, Jieun Uhm.
Int J Mol Sci, 2019 Mar 20; 20(6). PMID: 30884772    Free PMC article.
Molecular Interactions of Antibody Drugs Targeting PD-1, PD-L1, and CTLA-4 in Immuno-Oncology.
Hyun Tae Lee, Sang Hyung Lee, Yong-Seok Heo.
Molecules, 2019 Mar 29; 24(6). PMID: 30917623    Free PMC article.
Activated Macrophages of Monocytic Origin Predominantly Express Proinflammatory Cytokine Genes, Whereas Kupffer Cells Predominantly Express Anti-Inflammatory Cytokine Genes.
Anastasia Lokhonina, Andrey Elchaninov, +8 authors, Gennady Sukhikh.
Biomed Res Int, 2019 Apr 06; 2019. PMID: 30949499    Free PMC article.
Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus.
Haiyan Zhou, Bojiang Li, +7 authors, Fang Yu.
Mediators Inflamm, 2019 Apr 23; 2019. PMID: 31007604    Free PMC article.
CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?
Bogdan Musielak, Justyna Kocik, +7 authors, Jacek Plewka.
Molecules, 2019 Aug 04; 24(15). PMID: 31374878    Free PMC article.
A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq.
Angela C Boroughs, Rebecca C Larson, +17 authors, Marcela V Maus.
Mol Ther, 2020 Aug 07; 28(12). PMID: 32755564    Free PMC article.
Biomarker Development for Metastatic Renal Cell Carcinoma: Omics, Antigens, T-cells, and Beyond.
Benjamin Miron, David Xu, Matthew Zibelman.
J Pers Med, 2020 Nov 19; 10(4). PMID: 33202724    Free PMC article.
Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism.
Volker Schirrmacher.
Biomedicines, 2020 Dec 04; 8(11). PMID: 33266387    Free PMC article.
Dynamical Boolean Modeling of Immunogenic Cell Death.
Andrea Checcoli, Jonathan G Pol, +6 authors, Gautier Stoll.
Front Physiol, 2020 Dec 08; 11. PMID: 33281620    Free PMC article.
4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells.
Qiang Dai, Ping Han, +6 authors, Xuanming Yang.
Front Immunol, 2020 Dec 08; 11. PMID: 33281809    Free PMC article.
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy.
Yuka Igarashi, Tetsuro Sasada.
J Immunol Res, 2020 Dec 08; 2020. PMID: 33282961    Free PMC article.
T-cell responses and therapies against SARS-CoV-2 infection.
Salman M Toor, Reem Saleh, +2 authors, Eyad Elkord.
Immunology, 2020 Sep 17; 162(1). PMID: 32935333    Free PMC article.
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors.
Vid Leko, Steven A Rosenberg.
Cancer Cell, 2020 Aug 22; 38(4). PMID: 32822573    Free PMC article.
Biotherapeutic Antibodies for the Treatment of Head and Neck Cancer: Current Approaches and Future Considerations of Photothermal Therapies.
Mohammed M Al Qaraghuli.
Front Oncol, 2020 Dec 17; 10. PMID: 33324546    Free PMC article.
The Adipocyte and Adaptive Immunity.
Jianfeng Song, Tuo Deng.
Front Immunol, 2020 Dec 18; 11. PMID: 33329579    Free PMC article.
Overexpression of CD155 is associated with PD-1 and PD-L1 expression on immune cells, rather than tumor cells in the breast cancer microenvironment.
Rui-Bin Wang, Yu-Chen Li, +6 authors, Bin Zhu.
World J Clin Cases, 2020 Dec 22; 8(23). PMID: 33344592    Free PMC article.
4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39+ CD8 T cells from primary and metastatic sites of epithelial ovarian cancers.
Galam Leem, Junsik Park, +12 authors, Su-Hyung Park.
J Immunother Cancer, 2020 Dec 19; 8(2). PMID: 33335029    Free PMC article.
The immune system view of the coronavirus SARS-CoV-2.
Ivana Celardo, Luigia Pace, +2 authors, Vincenzo Barnaba.
Biol Direct, 2020 Dec 30; 15(1). PMID: 33371901    Free PMC article.
The Anticancer Potential of T Cell Receptor-Engineered T Cells.
Matyas Ecsedi, Megan S McAfee, Aude G Chapuis.
Trends Cancer, 2020 Sep 30; 7(1). PMID: 32988787    Free PMC article.
Patients with systemic lupus erythematosus show increased proportions of CD19+CD20- B cells and secretion of related autoantibodies.
Qingqing Zhu, Yun Li, +8 authors, Changhao Xie.
Clin Rheumatol, 2020 Jun 17; 40(1). PMID: 32542581
From biomarkers to therapeutic targets: the promise of PD-L1 in thyroid autoimmunity and cancer.
Grégoire D'Andréa, Sandra Lassalle, +2 authors, Paul Hofman.
Theranostics, 2021 Jan 05; 11(3). PMID: 33391536    Free PMC article.
Targeting TGFβ signal transduction for cancer therapy.
Sijia Liu, Jiang Ren, Peter Ten Dijke.
Signal Transduct Target Ther, 2021 Jan 09; 6(1). PMID: 33414388    Free PMC article.
Association of OX40 gene polymorphisms (rs17568G/A and rs229811A/C) with head and neck squamous cell carcinoma.
Zahra Faghih, Shabnam Abtahi, +2 authors, Nasrollah Erfani.
Mol Biol Rep, 2019 Mar 30; 46(3). PMID: 30923998
CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice.
Cheng Ye, Benjamin E Low, +3 authors, John P Driver.
J Immunol, 2020 Sep 02; 205(7). PMID: 32868408    Free PMC article.
The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy.
Anastasia Mpakali, Efstratios Stratikos.
Cancers (Basel), 2021 Jan 08; 13(1). PMID: 33406696    Free PMC article.
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity.
Dan Lu, Liang Liu, +14 authors, Yuxin Yin.
Nat Immunol, 2020 Jan 15; 21(3). PMID: 31932812
The transcription factor Zfp281 sustains CD4+ T lymphocyte activation through directly repressing Ctla-4 transcription.
Jing Guo, Zhonghui Xue, +9 authors, Lie Wang.
Cell Mol Immunol, 2019 Sep 13; 17(12). PMID: 31511645    Free PMC article.
TRAIL regulates T cell activation and suppresses inflammation in autoimmune diseases.
I-Tsu Chyuan, Ping-Ning Hsu.
Cell Mol Immunol, 2020 Mar 27; 17(12). PMID: 32210394    Free PMC article.
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
Masahiro Kiuchi, Atsushi Onodera, +8 authors, Toshinori Nakayama.
J Exp Med, 2021 Jan 13; 218(4). PMID: 33433611    Free PMC article.
The Combinatorial Effect of Cisplatin and Moxibustion on Tumor Growth Inhibition with Special Reference to Modulation of the Immune Microenvironment in Lewis Lung Cancer Mice.
Bin Wang, Jin Huang, +10 authors, Yi Guo.
Evid Based Complement Alternat Med, 2021 Jan 19; 2020. PMID: 33456484    Free PMC article.
Immunobiology of T Cells in Sjögren's Syndrome.
Yuan Yao, Jin-Fen Ma, +4 authors, Zhe-Xiong Lian.
Clin Rev Allergy Immunol, 2020 May 12; 60(1). PMID: 32390096
Multiregion single-cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer.
Wei Wang, Yu Zhong, +26 authors, Xueqing Yao.
Clin Transl Med, 2021 Jan 20; 11(1). PMID: 33463049    Free PMC article.
Functional Heterogeneity and Therapeutic Targeting of Tissue-Resident Memory T Cells.
Esmé T I van der Gracht, Felix M Behr, Ramon Arens.
Cells, 2021 Jan 21; 10(1). PMID: 33467606    Free PMC article.
Immune regulation in renal inflammation.
Katrin Neumann, Gisa Tiegs.
Cell Tissue Res, 2021 Jan 27; 385(2). PMID: 33496881    Free PMC article.
Determining Factors in the Therapeutic Success of Checkpoint Immunotherapies against PD-L1 in Breast Cancer: A Focus on Epithelial-Mesenchymal Transition Activation.
Mariana Segovia-Mendoza, Susana Romero-Garcia, Cristina Lemini, Heriberto Prado-Garcia.
J Immunol Res, 2021 Jan 29; 2021. PMID: 33506060    Free PMC article.
Mining The Cancer Genome Atlas database for tumor mutation burden and its clinical implications in gastric cancer.
Dong-Yan Zhao, Xi-Zhen Sun, Shu-Kun Yao.
World J Gastrointest Oncol, 2021 Jan 30; 13(1). PMID: 33510848    Free PMC article.
Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion.
Guillem Angulo, Jelena Zeleznjak, +8 authors, Ana Angulo.
Elife, 2021 Jan 19; 10. PMID: 33459589    Free PMC article.
Engineering advanced logic and distributed computing in human CAR immune cells.
Jang Hwan Cho, Atsushi Okuma, +3 authors, Wilson W Wong.
Nat Commun, 2021 Feb 06; 12(1). PMID: 33542232    Free PMC article.
Development and Use of the Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy Axicabtagene Ciloleucel in Large B-Cell Lymphoma: A Review.
Frederick L Locke, William Y Go, Sattva S Neelapu.
JAMA Oncol, 2019 Nov 08; 6(2). PMID: 31697310    Free PMC article.
The BTLA and PD-1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood γδ T cells.
Hyun J Hwang, Jae J Lee, +7 authors, Nayoung Kim.
Immun Inflamm Dis, 2020 Dec 18; 9(1). PMID: 33332777    Free PMC article.
Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy.
Ariel Isser, Natalie K Livingston, Jonathan P Schneck.
Biomaterials, 2020 Dec 19; 268. PMID: 33338931    Free PMC article.
The Updated Status and Future Direction of Immunotherapy Targeting B7-H1/PD-1 in Osteosarcoma.
Meng-Ke Fan, Li-Li Qi, Qi Zhang, Ling Wang.
Cancer Manag Res, 2021 Feb 05; 13. PMID: 33536783    Free PMC article.
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy.
Riyao Yang, Linlin Sun, +14 authors, Mien-Chie Hung.
Nat Commun, 2021 Feb 07; 12(1). PMID: 33547304    Free PMC article.
Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models.
Jordi Guiteras, Laura De Ramon, +10 authors, Joan Torras.
Int J Mol Sci, 2021 Feb 04; 22(3). PMID: 33530581    Free PMC article.
Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types.
Mayanne M T Zhu, Samantha Burugu, +5 authors, Torsten O Nielsen.
Mod Pathol, 2020 May 01; 33(9). PMID: 32350416
Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT.
Xiaowen Zhou, Jiangfeng Du, +12 authors, Yanfeng Gao.
Cell Commun Signal, 2021 Feb 10; 19(1). PMID: 33557880    Free PMC article.
Current understanding of cancer-intrinsic PD-L1: regulation of expression and its protumoral activity.
Pedram Yadollahi, You-Kyoung Jeon, Wooi Loon Ng, Inhak Choi.
BMB Rep, 2020 Dec 11; 54(1). PMID: 33298250    Free PMC article.
αβγδ T cells play a vital role in fetal human skin development and immunity.
René Reitermaier, Thomas Krausgruber, +16 authors, Adelheid Elbe-Bürger.
J Exp Med, 2021 Feb 10; 218(4). PMID: 33561194    Free PMC article.
PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma.
Naoya Maekawa, Satoru Konnai, +16 authors, Kazuhiko Ohashi.
NPJ Precis Oncol, 2021 Feb 14; 5(1). PMID: 33580183    Free PMC article.
Influence of aging on T cell response and renin-angiotensin system imbalance during SARS-CoV-2 infection.
Jorge Quarleri, Cintia Cevallos, M Victoria Delpino.
Immunol Lett, 2021 Feb 14; 232. PMID: 33581170    Free PMC article.
Immune Checkpoint-Related Gene Polymorphisms Are Associated With Primary Immune Thrombocytopenia.
Shuwen Wang, Xiaoyu Zhang, +8 authors, Xiang Hu.
Front Immunol, 2021 Feb 16; 11. PMID: 33584705    Free PMC article.
Immunotherapeutic advances in gastric cancer.
Akira Yoneda, Tamotsu Kuroki, Susumu Eguchi.
Surg Today, 2021 Feb 17; 51(11). PMID: 33590326
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells.
Rebekka Duhen, Carmen Ballesteros-Merino, +12 authors, Andrew D Weinberg.
Nat Commun, 2021 Feb 18; 12(1). PMID: 33594075    Free PMC article.
B7-H3 is spliced by SRSF3 in colorectal cancer.
Chunxia Zhang, Yinshuang Chen, +5 authors, Weipeng Wang.
Cancer Immunol Immunother, 2020 Jul 29; 70(2). PMID: 32719950
Anti-Mesothelin CAR T cell therapy for malignant mesothelioma.
Laura Castelletti, Dannel Yeo, Nico van Zandwijk, John E J Rasko.
Biomark Res, 2021 Feb 17; 9(1). PMID: 33588928    Free PMC article.
Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation.
Kingsley Gideon Kumashie, Marcin Cebula, +5 authors, Dagmar Wirth.
Front Immunol, 2021 Feb 23; 11. PMID: 33613516    Free PMC article.
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway.
Tsukasa Oda, Ruri Nakamura, +6 authors, Takayuki Yamashita.
Cancer Gene Ther, 2021 Feb 24; 29(2). PMID: 33619341
The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.
Asif A Dar, Keisuke Sawada, +8 authors, Paula M Oliver.
PLoS Biol, 2021 Feb 02; 19(2). PMID: 33524014    Free PMC article.
Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment.
Lesang Shen, Yunxiang Zhou, +6 authors, Jian Huang.
Oxid Med Cell Longev, 2021 Feb 26; 2021. PMID: 33628389    Free PMC article.
Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance.
Qian Yang, Ruijing Zhang, +16 authors, Xiaofeng Yang.
J Immunol Res, 2021 Feb 26; 2021. PMID: 33628851    Free PMC article.
Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy.
Weiqin Jiang, Yinjun He, +9 authors, Hanju Hua.
Front Immunol, 2021 Feb 27; 11. PMID: 33633741    Free PMC article.
Clinical significance of CD28 gene-related activating alterations in adult T-cell leukaemia/lymphoma.
Yuma Sakamoto, Takashi Ishida, +10 authors, Hiroshi Inagaki.
Br J Haematol, 2020 Nov 19; 192(2). PMID: 33205842    Free PMC article.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.
Javid Moslehi, Andrew H Lichtman, +2 authors, Richard N Kitsis.
J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548    Free PMC article.
ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis.
Timoteo Marchini, Sophie Hansen, Dennis Wolf.
Cells, 2021 Mar 07; 10(2). PMID: 33669769    Free PMC article.
TNF in the era of immune checkpoint inhibitors: friend or foe?
Allen Y Chen, Jedd D Wolchok, Anne R Bass.
Nat Rev Rheumatol, 2021 Mar 10; 17(4). PMID: 33686279    Free PMC article.
Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study.
Qinchuan Wang, Yuanqing Ye, +6 authors, Xifeng Wu.
Cancer Immunol Immunother, 2020 Sep 11; 70(3). PMID: 32909077    Free PMC article.
Effective Activation and Expansion of Canine Lymphocytes Using a Novel Nano-Sized Magnetic Beads Approach.
Iwona Monika Szopa, Monika Granica, +4 authors, Kinga Majchrzak-Kuligowska.
Front Immunol, 2021 Mar 09; 12. PMID: 33679741    Free PMC article.
In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET.
Marco F Taddio, Claudia A Castro Jaramillo, +8 authors, Stefanie D Krämer.
Mol Imaging Biol, 2020 Sep 30; 23(2). PMID: 32989622    Free PMC article.
Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage.
Yuan Hong, Yingcai Feng, +12 authors, Ye Liu.
FEBS Open Bio, 2021 Feb 03; 11(3). PMID: 33527708    Free PMC article.
Biomechanics of T Cell Dysfunctions in Chronic Diseases.
Sachith D Gunasinghe, Newton G Peres, Jesse Goyette, Katharina Gaus.
Front Immunol, 2021 Mar 16; 12. PMID: 33717081    Free PMC article.
Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1.
Ariana N Renrick, Menaka C Thounaojam, +4 authors, Anil Shanker.
Front Immunol, 2021 Mar 16; 12. PMID: 33717088    Free PMC article.
Recurrent Sepsis Exacerbates CD4+ T Cell Exhaustion and Decreases Antiviral Immune Responses.
Wanxue He, Kun Xiao, +6 authors, Lixin Xie.
Front Immunol, 2021 Mar 16; 12. PMID: 33717146    Free PMC article.
Immunological Feature and Transcriptional Signaling of Ly6C Monocyte Subsets From Transcriptome Analysis in Control and Hyperhomocysteinemic Mice.
Pingping Yang, Lu Liu, +9 authors, Hong Wang.
Front Immunol, 2021 Mar 16; 12. PMID: 33717169    Free PMC article.
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.
Shannon K Oda, Kristin G Anderson, +8 authors, Philip D Greenberg.
J Exp Med, 2020 Aug 30; 217(12). PMID: 32860705    Free PMC article.
Why do intestinal epithelial cells express MHC class II?
Cornelia Heuberger, Johanna Pott, Kevin Joseph Maloy.
Immunology, 2020 Sep 24; 162(4). PMID: 32966619    Free PMC article.
Recent Advances in Costimulatory Blockade to Induce Immune Tolerance in Liver Transplantation.
Mingjie Ding, Yuting He, Shuijun Zhang, Wenzhi Guo.
Front Immunol, 2021 Mar 19; 12. PMID: 33732228    Free PMC article.
Virus-specific T cells for malignancies - then, now and where to?
Sandhya Sharma, Wingchi K Leung, Helen E Heslop.
Curr Stem Cell Rep, 2021 Mar 20; 6(2). PMID: 33738181    Free PMC article.
Next generation of immune checkpoint inhibitors and beyond.
Julian A Marin-Acevedo, ErinMarie O Kimbrough, Yanyan Lou.
J Hematol Oncol, 2021 Mar 21; 14(1). PMID: 33741032    Free PMC article.
Roles of the Dynamic Tumor Immune Microenvironment in the Individualized Treatment of Advanced Clear Cell Renal Cell Carcinoma.
Enyu Lin, Xuechao Liu, +5 authors, Yuming Yu.
Front Immunol, 2021 Mar 23; 12. PMID: 33746989    Free PMC article.
Tackling Immune Targets for Breast Cancer: Beyond PD-1/PD-L1 Axis.
Yasser Tabana, Isobel S Okoye, +2 authors, Khaled H Barakat.
Front Oncol, 2021 Mar 23; 11. PMID: 33747948    Free PMC article.
Functional Characteristics and Phenotypic Plasticity of CD57+PD1- CD4 T Cells and Their Relationship with Transplant Immunosuppression.
Brian I Shaw, Jaclyn R Espinosa, +3 authors, Allan D Kirk.
J Immunol, 2021 Feb 19; 206(7). PMID: 33597150    Free PMC article.
TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients.
Jana Rakova, Iva Truxova, +12 authors, Jitka Fucikova.
Oncoimmunology, 2021 Mar 25; 10(1). PMID: 33758676    Free PMC article.
Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy.
Iris Lodewijk, Sandra P Nunes, +3 authors, Jesús M Paramio.
Clin Epigenetics, 2021 Mar 26; 13(1). PMID: 33761971    Free PMC article.
4-1BB costimulation promotes bystander activation of human CD8 T cells.
Manuel Reithofer, Sandra Rosskopf, +4 authors, Beatrice Jahn-Schmid.
Eur J Immunol, 2020 Nov 13; 51(3). PMID: 33180337    Free PMC article.
Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer Patients.
Claire Germain, Priyanka Devi-Marulkar, +16 authors, Marie-Caroline Dieu-Nosjean.
Front Immunol, 2021 Mar 26; 12. PMID: 33763071    Free PMC article.
Phenotypic and Functional Analyses Guiding Combination Immune Checkpoint Immunotherapeutic Strategies in HTLV-1 Infection.
Danielle M Clements, Brenndan Crumley, +5 authors, Pooja Jain.
Front Immunol, 2021 Mar 27; 12. PMID: 33767694    Free PMC article.
Functional crosstalk between T cells and monocytes in cancer and atherosclerosis.
Lindsey E Padgett, Daniel J Araujo, Catherine C Hedrick, Claire E Olingy.
J Leukoc Biol, 2020 Jun 13; 108(1). PMID: 32531833    Free PMC article.
Biomarkers in Immunotherapy-Based Precision Treatments of Digestive System Tumors.
Zhu Zeng, Biao Yang, Zhengyin Liao.
Front Oncol, 2021 Mar 30; 11. PMID: 33777812    Free PMC article.
A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells.
Zhaoqian Su, Kalyani Dhusia, Yinghao Wu.
PLoS Comput Biol, 2021 Mar 09; 17(3). PMID: 33684103    Free PMC article.
LAG-3-Expressing Tumor-Infiltrating T Cells Are Associated with Reduced Disease-Free Survival in Pancreatic Cancer.
Lena Seifert, Ioana Plesca, +9 authors, Adrian M Seifert.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33803936    Free PMC article.
Cell Surface Profiling of Retinal Müller Glial Cells Reveals Association to Immune Pathways after LPS Stimulation.
Lea Lorenz, Sieglinde Hirmer, +2 authors, Cornelia A Deeg.
Cells, 2021 Apr 04; 10(3). PMID: 33806940    Free PMC article.
Comprehensive genomic analysis identifying heterogeneity in peripheral T-cell lymphoma.
Noriaki Yoshida, Kyohei Yamada, Koichi Ohshima.
Cancer Sci, 2021 Feb 13; 112(4). PMID: 33576080    Free PMC article.
Emerging Molecular Connections between NM23 Proteins, Telomeres and Telomere-Associated Factors: Implications in Cancer Metastasis and Ageing.
Shalu Sharma, Antara Sengupta, Shantanu Chowdhury.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33801585    Free PMC article.
Engaging the Innate and Adaptive Antitumor Immune Response in Lymphoma.
Clifford M Csizmar, Stephen M Ansell.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33804869    Free PMC article.
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Spencer C Wei, Wouter C Meijers, +24 authors, James P Allison.
Cancer Discov, 2020 Dec 02; 11(3). PMID: 33257470    Free PMC article.
Structural Basis of VSIG3: The Ligand for VISTA.
Xiaoxue Xie, Caiping Chen, +5 authors, Jun Liu.
Front Immunol, 2021 Apr 13; 12. PMID: 33841409    Free PMC article.
Advances in immunotherapy for hepatocellular carcinoma.
Bruno Sangro, Pablo Sarobe, Sandra Hervás-Stubbs, Ignacio Melero.
Nat Rev Gastroenterol Hepatol, 2021 Apr 15; 18(8). PMID: 33850328    Free PMC article.
MHC heterogeneity and response of metastases to immunotherapy.
Ignacio Algarra, Federico Garrido, Angel M Garcia-Lora.
Cancer Metastasis Rev, 2021 Apr 17; 40(2). PMID: 33860434
Novel approaches to enhance the specificity and safety of engineered T cells.
Victor D Fedorov, Michel Sadelain, Christopher C Kloss.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667964    Free PMC article.
Default polyfunctional T helper 1 response to ample signal 1 alone.
Luca Danelli, Georgina Cornish, Julia Merkenschlager, George Kassiotis.
Cell Mol Immunol, 2020 Apr 22; 18(7). PMID: 32313208    Free PMC article.
Function and Role of Regulatory T Cells in Rheumatoid Arthritis.
Qi Jiang, Guocan Yang, +2 authors, Dawei Cui.
Front Immunol, 2021 Apr 20; 12. PMID: 33868244    Free PMC article.
Cellular networks controlling T cell persistence in adoptive cell therapy.
Jack D Chan, Junyun Lai, +3 authors, Phillip K Darcy.
Nat Rev Immunol, 2021 Apr 22; 21(12). PMID: 33879873
CytoTalk: De novo construction of signal transduction networks using single-cell transcriptomic data.
Yuxuan Hu, Tao Peng, Lin Gao, Kai Tan.
Sci Adv, 2021 Apr 16; 7(16). PMID: 33853780    Free PMC article.
Inhibition of acid sphingomyelinase increases regulatory T cells in humans.
Teresa Wiese, Fabio Dennstädt, +16 authors, Niklas Beyersdorf.
Brain Commun, 2021 Apr 27; 3(2). PMID: 33898989    Free PMC article.
Frontiers and Opportunities: Highlights of the 2nd Annual Conference of the Chinese Antibody Society.
Hongyu Zhang, Mi Deng, +5 authors, Mitchell Ho.
Antib Ther, 2018 Nov 09; 1(2). PMID: 30406214    Free PMC article.
TIM-3 drives temporal differences in restimulation-induced cell death sensitivity in effector CD8+ T cells in conjunction with CEACAM1.
Camille M Lake, Kelsey Voss, +4 authors, Andrew L Snow.
Cell Death Dis, 2021 Apr 16; 12(4). PMID: 33854046    Free PMC article.
Intersection of DNA Repair Pathways and the Immune Landscape Identifies PD-L2 as a Prognostic Marker in Epithelial Ovarian Cancer.
Samantha Batman, Koji Matsuo, +8 authors, Tanja Pejovic.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33923934    Free PMC article.
In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs.
Sean Hammond, Paul Thomson, Xiaoli Meng, Dean Naisbitt.
Front Immunol, 2021 May 01; 12. PMID: 33927714    Free PMC article.
T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments.
Naval Daver, Ahmad S Alotaibi, Veit Bücklein, Marion Subklewe.
Leukemia, 2021 May 07; 35(7). PMID: 33953290    Free PMC article.
Combination blockade of OX40L and CD30L inhibits allergen-driven memory TH2 cell reactivity and lung inflammation.
Donald T Gracias, Gurupreet S Sethi, +4 authors, Michael Croft.
J Allergy Clin Immunol, 2020 Nov 09; 147(6). PMID: 33160971    Free PMC article.
Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.
Xuqing Zhang, Mengyao Luo, +19 authors, Tiffany F Chen.
Nat Commun, 2021 May 13; 12(1). PMID: 33976146    Free PMC article.
Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity.
Yiwen Zhang, Hongrong Hu, +12 authors, Hui Zhang.
J Immunother Cancer, 2021 Apr 23; 9(4). PMID: 33883257    Free PMC article.
Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer.
Anita K Mehta, Sapana Kadel, +2 authors, Jennifer L Guerriero.
Front Immunol, 2021 May 11; 12. PMID: 33968034    Free PMC article.
Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1.
Weimin Chen, Madhu Pandey, +7 authors, Shihua Lin.
MAbs, 2021 Apr 20; 13(1). PMID: 33870864    Free PMC article.
Insulin Signaling in Arthritis.
Cesare Tripolino, Jacopo Ciaffi, +6 authors, Francesco Ursini.
Front Immunol, 2021 May 18; 12. PMID: 33995414    Free PMC article.
Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity.
Meihua Qiu, Yuqing Chen, Qiao Ye.
BMC Pulm Med, 2021 May 24; 21(1). PMID: 34022844    Free PMC article.
Programmed cell death-1 single-nucleotide polymorphism rs10204525 is associated with human immunodeficiency virus type 1 RNA viral load in HIV-1-infected Moroccan subjects.
Hanâ Baba, Anass Kettani, +10 authors, Lahcen Wakrim.
Med Microbiol Immunol, 2021 May 26; 210(4). PMID: 34031715
Glycosylation of Immune Receptors in Cancer.
Ruoxuan Sun, Alyssa Min Jung Kim, Seung-Oe Lim.
Cells, 2021 Jun 03; 10(5). PMID: 34064396    Free PMC article.
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model.
Shuyang S Qin, Booyeon J Han, +9 authors, Peter A Prieto.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34064795    Free PMC article.
CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection.
Vuvi G Tran, Na N Z Nguyen, Byungsuk Kwon.
J Fungi (Basel), 2021 Jun 03; 7(5). PMID: 34068963    Free PMC article.
Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control.
Dafne C A Quixabeira, Sadia Zafar, +7 authors, Akseli Hemminki.
Front Immunol, 2021 Jun 05; 12. PMID: 34084172    Free PMC article.
B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.
Sadiye Amcaoglu Rieder, Jingya Wang, +6 authors, Roland Kolbeck.
Cell Mol Immunol, 2020 Feb 02; 18(6). PMID: 32005952    Free PMC article.
Immune checkpoints in targeted-immunotherapy of pancreatic cancer: New hope for clinical development.
Seyed Hossein Kiaie, Mohammad Javad Sanaei, +5 authors, Behzad Baradaran.
Acta Pharm Sin B, 2021 Jun 08; 11(5). PMID: 34094821    Free PMC article.
CAR T-cell therapy for pleural mesothelioma: Rationale, preclinical development, and clinical trials.
Navin K Chintala, David Restle, +5 authors, Prasad S Adusumilli.
Lung Cancer, 2021 May 12; 157. PMID: 33972125    Free PMC article.
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells.
Zhiliang Bai, Stefan Lundh, +9 authors, Rong Fan.
J Immunother Cancer, 2021 May 20; 9(5). PMID: 34006631    Free PMC article.
Treg-Resistant Cytotoxic CD4+ T Cells Dictate T Helper Cells in Their Vicinity: TH17 Skewing and Modulation of Proliferation.
Cindy Hoeks, Marjan Vanheusden, +3 authors, Niels Hellings.
Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34073458    Free PMC article.
Integrated analysis identifies S100A16 as a potential prognostic marker for pancreatic cancer.
Tian Chen, De-Meng Xia, Chao Qian, Shan-Rong Liu.
Am J Transl Res, 2021 Jun 22; 13(5). PMID: 34150181    Free PMC article.
Comprehensive landscape of immune-checkpoints uncovered in clear cell renal cell carcinoma reveals new and emerging therapeutic targets.
Diana Tronik-Le Roux, Mathilde Sautreuil, +9 authors, Edgardo D Carosella.
Cancer Immunol Immunother, 2020 Mar 14; 69(7). PMID: 32166404
Determination of the molecular reach of the protein tyrosine phosphatase SHP-1.
Lara Clemens, Mikhail Kutuzov, +3 authors, Omer Dushek.
Biophys J, 2021 Mar 31; 120(10). PMID: 33781765    Free PMC article.
Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes.
Kin Man Au, Yusra Medik, +2 authors, Andrew Z Wang.
Adv Mater, 2021 May 09; 33(25). PMID: 33963786    Free PMC article.
Immunological considerations and challenges for regenerative cellular therapies.
Sandra Petrus-Reurer, Marco Romano, +3 authors, Kourosh Saeb-Parsy.
Commun Biol, 2021 Jun 27; 4(1). PMID: 34172826    Free PMC article.
Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation.
Sushila A Toulmin, Chaitali Bhadiadra, +6 authors, Laurence C Eisenlohr.
Nat Commun, 2021 Jun 30; 12(1). PMID: 34183650    Free PMC article.
Two Complementarity Immunotherapeutics in Non-Small-Cell Lung Cancer Patients-Mechanism of Action and Future Concepts.
Kamila Wojas-Krawczyk, Paweł Krawczyk, Michał Gil, Maciej Strzemski.
Cancers (Basel), 2021 Jul 03; 13(11). PMID: 34200219    Free PMC article.
Strength and Numbers: The Role of Affinity and Avidity in the 'Quality' of T Cell Tolerance.
Sébastien This, Stefanie F Valbon, Marie-Ève Lebel, Heather J Melichar.
Cells, 2021 Jul 03; 10(6). PMID: 34204485    Free PMC article.
Synergistic Activation of Bovine CD4+ T Cells by Neutrophils and IL-12.
Zhengguo Xiao, Anmol Kandel, Lei Li.
Pathogens, 2021 Jul 03; 10(6). PMID: 34204973    Free PMC article.
OX40L-OX40 Signaling in Atopic Dermatitis.
Masutaka Furue, Mihoko Furue.
J Clin Med, 2021 Jul 03; 10(12). PMID: 34208041