Journal Article
. 2013 Mar; 368(16):1509-1518.
doi: 10.1056/NEJMoa1215134.

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

Stephan A Grupp 1 Michael Kalos 1 David Barrett 1 Richard Aplenc 1 David L Porter 1 Susan R Rheingold 1 David T Teachey 1 Anne Chew 1 Bernd Hauck 1 J Fraser Wright 1 Michael C Milone 1 Bruce L Levine 1 Carl H June 1 
Affiliations
  • PMID: 23527958
  •     26 References
  •     1432 citations

Abstract

Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric antigen receptor T cells have clinical activity in acute lymphoblastic leukemia (ALL). Two children with relapsed and refractory pre-B-cell ALL received infusions of T cells transduced with anti-CD19 antibody and a T-cell signaling molecule (CTL019 chimeric antigen receptor T cells), at a dose of 1.4×10(6) to 1.2×10(7) CTL019 cells per kilogram of body weight. In both patients, CTL019 T cells expanded to a level that was more than 1000 times as high as the initial engraftment level, and the cells were identified in bone marrow. In addition, the chimeric antigen receptor T cells were observed in the cerebrospinal fluid (CSF), where they persisted at high levels for at least 6 months. Eight grade 3 or 4 adverse events were noted. The cytokine-release syndrome and B-cell aplasia developed in both patients. In one child, the cytokine-release syndrome was severe; cytokine blockade with etanercept and tocilizumab was effective in reversing the syndrome and did not prevent expansion of chimeric antigen receptor T cells or reduce antileukemic efficacy. Complete remission was observed in both patients and is ongoing in one patient at 11 months after treatment. The other patient had a relapse, with blast cells that no longer expressed CD19, approximately 2 months after treatment. Chimeric antigen receptor-modified T cells are capable of killing even aggressive, treatment-refractory acute leukemia cells in vivo. The emergence of tumor cells that no longer express the target indicates a need to target other molecules in addition to CD19 in some patients with ALL.

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MAbs, 2014 Mar 05; 6(3). PMID: 24589717    Free PMC article.
Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells.
Saar Gill, Sarah K Tasian, +9 authors, Michael Kalos.
Blood, 2014 Mar 07; 123(15). PMID: 24596416    Free PMC article.
Highly Cited.
Clinical utility of natural killer cells in cancer therapy and transplantation.
David A Knorr, Veronika Bachanova, Michael R Verneris, Jeffrey S Miller.
Semin Immunol, 2014 Mar 13; 26(2). PMID: 24618042    Free PMC article.
Highly Cited. Review.
Novel antibody therapy in acute lymphoblastic leukemia.
Samith T Kochuparambil, Mark R Litzow.
Curr Hematol Malig Rep, 2014 Mar 14; 9(2). PMID: 24623281
Review.
Immunotherapy: opportunities, risks and future perspectives.
Martin Hildebrandt, Karl Peggs, +2 authors, Helen E Heslop.
Cytotherapy, 2014 Mar 19; 16(4 Suppl). PMID: 24629797    Free PMC article.
Review.
Functional NK cell repertoires are maintained through IL-2Rα and Fas ligand.
Martin Felices, Todd R Lenvik, +6 authors, Jeffrey S Miller.
J Immunol, 2014 Mar 19; 192(8). PMID: 24634493    Free PMC article.
Systemic inflammatory response syndrome after administration of unmodified T lymphocytes.
Anastasia Papadopoulou, Robert A Krance, +5 authors, Helen E Heslop.
Mol Ther, 2014 Mar 22; 22(6). PMID: 24651135    Free PMC article.
B7-H4 as a potential target for immunotherapy for gynecologic cancers: a closer look.
Jenessa B Smith, Caitlin Stashwick, Daniel J Powell.
Gynecol Oncol, 2014 Mar 25; 134(1). PMID: 24657487    Free PMC article.
Review.
Glioblastoma cancer stem cells: Biomarker and therapeutic advances.
Kelli B Pointer, Paul A Clark, +2 authors, John S Kuo.
Neurochem Int, 2014 Mar 25; 71. PMID: 24657832    Free PMC article.
Review.
CD19-CAR trials.
Carlos A Ramos, Barbara Savoldo, Gianpietro Dotti.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667955    Free PMC article.
Review.
Managing cytokine release syndrome associated with novel T cell-engaging therapies.
Shannon L Maude, David Barrett, David T Teachey, Stephan A Grupp.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667956    Free PMC article.
Highly Cited. Review.
Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition.
Stanley R Riddell, Daniel Sommermeyer, +6 authors, Cameron J Turtle.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667960    Free PMC article.
Review.
CAR T cells for solid tumors: armed and ready to go?
Sunitha Kakarla, Stephen Gottschalk.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667962    Free PMC article.
Highly Cited. Review.
Molecular therapeutic approaches for pediatric acute myeloid leukemia.
Sarah K Tasian, Jessica A Pollard, Richard Aplenc.
Front Oncol, 2014 Mar 29; 4. PMID: 24672775    Free PMC article.
Review.
Genetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells.
Jianhong Chu, Shun He, +11 authors, Jianhua Yu.
Clin Cancer Res, 2014 Mar 29; 20(15). PMID: 24677374    Free PMC article.
EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma.
Hongsheng Miao, Bryan D Choi, +11 authors, John H Sampson.
PLoS One, 2014 Apr 12; 9(4). PMID: 24722266    Free PMC article.
Reversal of tumor immune inhibition using a chimeric cytokine receptor.
Ann M Leen, Sujita Sukumaran, +9 authors, Juan F Vera.
Mol Ther, 2014 Apr 16; 22(6). PMID: 24732709    Free PMC article.
Therapeutic targeting of naturally presented myeloperoxidase-derived HLA peptide ligands on myeloid leukemia cells by TCR-transgenic T cells.
R Klar, S Schober, +12 authors, A M Krackhardt.
Leukemia, 2014 Apr 17; 28(12). PMID: 24736212
Cell transfer therapy for cancer: past, present, and future.
Xiaoling Qian, Xian Wang, Hongchuan Jin.
J Immunol Res, 2014 Apr 18; 2014. PMID: 24741604    Free PMC article.
Review.
Enhancement of the T-cell armamentarium as a cell-based therapy for prostate cancer.
W Nathaniel Brennen, Charles G Drake, John T Isaacs.
Cancer Res, 2014 Apr 22; 74(13). PMID: 24747912    Free PMC article.
An allogeneic NK cell line engineered to express chimeric antigen receptors: A novel strategy of cellular immunotherapy against cancer.
Cécile Badoual, Pierre-Louis Bastier, +2 authors, Eric Tartour.
Oncoimmunology, 2014 Apr 23; 2(11). PMID: 24753987    Free PMC article.
New strategies in ewing sarcoma: lost in translation?
Fernanda I Arnaldez, Lee J Helman.
Clin Cancer Res, 2014 Apr 24; 20(12). PMID: 24756371    Free PMC article.
Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013.
Marina O'Reilly, Howard J Federoff, +32 authors, Jacqueline Corrigan-Curay.
Hum Gene Ther, 2014 Apr 30; 25(6). PMID: 24773122    Free PMC article.
Review.
Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15.
Yang Xu, Ming Zhang, +10 authors, Gianpietro Dotti.
Blood, 2014 May 02; 123(24). PMID: 24782509    Free PMC article.
Highly Cited.
Antibody therapy for pediatric leukemia.
Aditi Vedi, David S Ziegler.
Front Oncol, 2014 May 06; 4. PMID: 24795859    Free PMC article.
Review.
New frontiers in pediatric Allo-SCT.
J M Talano, M A Pulsipher, +6 authors, M S Cairo.
Bone Marrow Transplant, 2014 May 14; 49(9). PMID: 24820213    Free PMC article.
Review.
Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance.
Stephanie R Jackson, Jinyun Yuan, +4 authors, Ryan M Teague.
J Leukoc Biol, 2014 May 16; 96(3). PMID: 24823810    Free PMC article.
Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing.
Yun Ji, Natalie Abrams, +9 authors, Nicholas P Restifo.
PLoS One, 2014 May 16; 9(5). PMID: 24827921    Free PMC article.
T cells redirected to interleukin-13Rα2 with interleukin-13 mutein--chimeric antigen receptors have anti-glioma activity but also recognize interleukin-13Rα1.
Simone Krebs, Kevin K H Chow, +5 authors, Stephen Gottschalk.
Cytotherapy, 2014 May 21; 16(8). PMID: 24841514    Free PMC article.
Declining childhood and adolescent cancer mortality: great progress but still much to be done.
Kathy Pritchard-Jones, Darren Hargrave.
Cancer, 2014 May 24; 120(16). PMID: 24853582    Free PMC article.
Current concepts in the diagnosis and management of cytokine release syndrome.
Daniel W Lee, Rebecca Gardner, +5 authors, Crystal L Mackall.
Blood, 2014 May 31; 124(2). PMID: 24876563    Free PMC article.
Highly Cited.
Boolean immunotherapy: reversal of fortune.
Richard A Morgan.
Mol Ther, 2014 Jun 03; 22(6). PMID: 24881766    Free PMC article.
Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity.
W K Chan, D Suwannasaen, +6 authors, W Leung.
Leukemia, 2014 Jun 04; 29(2). PMID: 24888271    Free PMC article.
Cell-based strategies to manage leukemia relapse: efficacy and feasibility of immunotherapy approaches.
A Rambaldi, E Biagi, +2 authors, M Introna.
Leukemia, 2014 Jun 13; 29(1). PMID: 24919807
Review.
Genetically modified T-cell therapy for osteosarcoma.
Christopher DeRenzo, Stephen Gottschalk.
Adv Exp Med Biol, 2014 Jun 14; 804. PMID: 24924183    Free PMC article.
Review.
New frontiers in pediatric Allo-SCT: novel approaches for children and adolescents with ALL.
M A Pulsipher, A S Wayne, K R Schultz.
Bone Marrow Transplant, 2014 Jun 17; 49(10). PMID: 24933210
Review.
Progress and prospects for engineered T cell therapies.
Waseem Qasim, Adrian J Thrasher.
Br J Haematol, 2014 Jun 18; 166(6). PMID: 24935654    Free PMC article.
Review.
Engineered T cells for cancer therapy.
Carl H June, Marcela V Maus, +5 authors, David L Porter.
Cancer Immunol Immunother, 2014 Jun 20; 63(9). PMID: 24943274    Free PMC article.
Review.
Chemokines as Cancer Vaccine Adjuvants.
Iuliana D Bobanga, Agne Petrosiute, Alex Y Huang.
Vaccines (Basel), 2014 Jun 27; 1(4). PMID: 24967094    Free PMC article.
ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells.
Sonia Guedan, Xi Chen, +9 authors, Carl H June.
Blood, 2014 Jul 06; 124(7). PMID: 24986688    Free PMC article.
Highly Cited.
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.
Pappanaicken R Kumaresan, Pallavi R Manuri, +14 authors, Laurence J N Cooper.
Proc Natl Acad Sci U S A, 2014 Jul 09; 111(29). PMID: 25002471    Free PMC article.
Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis.
Lehn K Weaver, Edward M Behrens.
Curr Opin Rheumatol, 2014 Jul 16; 26(5). PMID: 25022357    Free PMC article.
Review.
HSV-sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice.
Eric H Gschweng, Melissa N McCracken, +9 authors, Donald B Kohn.
Cancer Res, 2014 Jul 20; 74(18). PMID: 25038231    Free PMC article.
Engineering α-fetoprotein-based gene vaccines to prevent and treat hepatocellular carcinoma: review and future prospects.
Yukai He, Yuan Hong, Gerald J Mizejewski.
Immunotherapy, 2014 Jul 22; 6(6). PMID: 25041030    Free PMC article.
Review.
Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy.
Andras Heczey, Daofeng Liu, +10 authors, Leonid S Metelitsa.
Blood, 2014 Jul 23; 124(18). PMID: 25049283    Free PMC article.
Highly Cited.
Trial Watch: Adoptive cell transfer for anticancer immunotherapy.
Fernando Aranda, Erika Vacchelli, +8 authors, Lorenzo Galluzzi.
Oncoimmunology, 2014 Jul 23; 3. PMID: 25050207    Free PMC article.
Review.
CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
Sarah Tettamanti, Andrea Biondi, Ettore Biagi, Dominique Bonnet.
Oncoimmunology, 2014 Aug 02; 3. PMID: 25083319    Free PMC article.
Relapse post hematopoietic SCT remains the Achilles heel for the field.
H Frangoul, M Jagasia.
Bone Marrow Transplant, 2014 Aug 07; 49(8). PMID: 25096916
Lymphodepletion followed by infusion of suicide gene-transduced donor lymphocytes to safely enhance their antitumor effect: a phase I/II study.
S Maury, M Rosenzwajg, +18 authors, D Klatzmann.
Leukemia, 2014 Aug 12; 28(12). PMID: 25102947
Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma.
Nathan Singh, Xiaojun Liu, +5 authors, Yangbing Zhao.
Cancer Immunol Res, 2014 Aug 12; 2(11). PMID: 25104548    Free PMC article.
Acquired and intrinsic resistance in cancer immunotherapy.
Sander Kelderman, Ton N M Schumacher, John B A G Haanen.
Mol Oncol, 2014 Aug 12; 8(6). PMID: 25106088    Free PMC article.
Review.
Anti-leukemic potency of piggyBac-mediated CD19-specific T cells against refractory Philadelphia chromosome-positive acute lymphoblastic leukemia.
Shoji Saito, Yozo Nakazawa, +11 authors, Kenichi Koike.
Cytotherapy, 2014 Aug 12; 16(9). PMID: 25108652    Free PMC article.
Vaccines, new opportunities for a new society.
Rino Rappuoli, Mariagrazia Pizza, Giuseppe Del Giudice, Ennio De Gregorio.
Proc Natl Acad Sci U S A, 2014 Aug 20; 111(34). PMID: 25136130    Free PMC article.
Review.
Engager T cells: a new class of antigen-specific T cells that redirect bystander T cells.
Kota Iwahori, Sunitha Kakarla, +5 authors, Stephen Gottschalk.
Mol Ther, 2014 Aug 22; 23(1). PMID: 25142939    Free PMC article.
Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.
Raquel Gomez-Eerland, Bastiaan Nuijen, +8 authors, Annelies Jorritsma.
Hum Gene Ther Methods, 2014 Aug 22; 25(5). PMID: 25143008    Free PMC article.
Immunotherapy in pediatric malignancies: current status and future perspectives.
Christian M Capitini, Mario Otto, Kenneth B DeSantes, Paul M Sondel.
Future Oncol, 2014 Aug 26; 10(9). PMID: 25145434    Free PMC article.
Review.
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor.
James N Kochenderfer, Mark E Dudley, +23 authors, Steven A Rosenberg.
J Clin Oncol, 2014 Aug 27; 33(6). PMID: 25154820    Free PMC article.
Highly Cited.
Treatment of CD33-directed chimeric antigen receptor-modified T cells in one patient with relapsed and refractory acute myeloid leukemia.
Quan-shun Wang, Yao Wang, +5 authors, Wei-dong Han.
Mol Ther, 2014 Sep 02; 23(1). PMID: 25174587    Free PMC article.
Highly Cited.
T-cell immunotherapy: looking forward.
Jacqueline Corrigan-Curay, Hans-Peter Kiem, +23 authors, Donald B Kohn.
Mol Ther, 2014 Sep 05; 22(9). PMID: 25186558    Free PMC article.
The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors.
Alan D Guerrero, Judy S Moyes, Laurence J N Cooper.
Chin J Cancer, 2014 Sep 06; 33(9). PMID: 25189715    Free PMC article.
Cancer immunotherapy in clinical practice -- the past, present, and future.
Gaurav Goel, Weijing Sun.
Chin J Cancer, 2014 Sep 06; 33(9). PMID: 25189717    Free PMC article.
IL-6 in inflammation, immunity, and disease.
Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto.
Cold Spring Harb Perspect Biol, 2014 Sep 06; 6(10). PMID: 25190079    Free PMC article.
Highly Cited. Review.
Immunotherapy advances for glioblastoma.
David A Reardon, Gordon Freeman, +7 authors, Glenn Dranoff.
Neuro Oncol, 2014 Sep 06; 16(11). PMID: 25190673    Free PMC article.
Highly Cited. Review.
Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells.
Rachel E Beard, Zhili Zheng, +9 authors, Richard A Morgan.
J Immunother Cancer, 2014 Sep 10; 2. PMID: 25197555    Free PMC article.
Toward immunotherapy with redirected T cells in a large animal model: ex vivo activation, expansion, and genetic modification of canine T cells.
Melinda Mata, Juan F Vera, +6 authors, Stephen Gottschalk.
J Immunother, 2014 Sep 10; 37(8). PMID: 25198528    Free PMC article.
Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations.
Loren Gragert, Stephanie Fingerson, +3 authors, Brian T Hill.
Blood, 2014 Sep 19; 124(17). PMID: 25232063    Free PMC article.
Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects.
Huan Shi, Meili Sun, Lin Liu, Zhehai Wang.
Mol Cancer, 2014 Sep 23; 13. PMID: 25241075    Free PMC article.
Review.
From the mouse cage to human therapy: a personal perspective of the emergence of T-bodies/chimeric antigen receptor T cells.
Zelig Eshhar.
Hum Gene Ther, 2014 Sep 23; 25(9). PMID: 25244568    Free PMC article.
Toward synthetic biology with engineered T cells: a long journey just begun.
Carl H June.
Hum Gene Ther, 2014 Sep 23; 25(9). PMID: 25244569    Free PMC article.
Interleukin-13 receptor alpha 2-targeted glioblastoma immunotherapy.
Sadhak Sengupta, Bart Thaci, Andrew C Crawford, Prakash Sampath.
Biomed Res Int, 2014 Sep 24; 2014. PMID: 25247196    Free PMC article.
Review.
Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis.
Simona L Schlereth, Nasrin Refaian, +2 authors, Ludwig M Heindl.
Biomed Res Int, 2014 Sep 26; 2014. PMID: 25254213    Free PMC article.
Review.
PSMA-specific CAR-engineered T cells eradicate disseminated prostate cancer in preclinical models.
Gaia Zuccolotto, Giulio Fracasso, +8 authors, Antonio Rosato.
PLoS One, 2014 Oct 04; 9(10). PMID: 25279468    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Review.
The development of potential antibody-based therapies for myeloma.
Daniel W Sherbenou, Christopher R Behrens, +3 authors, Bin Liu.
Blood Rev, 2014 Oct 09; 29(2). PMID: 25294123    Free PMC article.
Review.
Characterizing immune repertoires by high throughput sequencing: strategies and applications.
Jorg J A Calis, Brad R Rosenberg.
Trends Immunol, 2014 Oct 13; 35(12). PMID: 25306219    Free PMC article.
Highly Cited. Review.
Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptors through trogocytosis.
Fu-Nan Cho, Tsung-Hsien Chang, +9 authors, Yu-Hsiang Chang.
PLoS One, 2014 Oct 15; 9(10). PMID: 25313995    Free PMC article.
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Shannon L Maude, Noelle Frey, +16 authors, Stephan A Grupp.
N Engl J Med, 2014 Oct 16; 371(16). PMID: 25317870    Free PMC article.
Highly Cited.
Immune-based therapies for childhood cancer.
Crystal L Mackall, Melinda S Merchant, Terry J Fry.
Nat Rev Clin Oncol, 2014 Oct 29; 11(12). PMID: 25348789    Free PMC article.
Review.
One-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism.
Lee Kim Swee, Sebastian Lourido, +2 authors, Hidde L Ploegh.
ACS Chem Biol, 2014 Nov 02; 10(2). PMID: 25360987    Free PMC article.
Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor.
Kurt Schönfeld, Christiane Sahm, +19 authors, Winfried S Wels.
Mol Ther, 2014 Nov 07; 23(2). PMID: 25373520    Free PMC article.
Highly Cited.
Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity.
Prasad S Adusumilli, Leonid Cherkassky, +5 authors, Michel Sadelain.
Sci Transl Med, 2014 Nov 08; 6(261). PMID: 25378643    Free PMC article.
Highly Cited.
Immunotherapy: Treatment of aggressive lymphomas with anti-CD19 CAR T cells.
Christopher A Klebanoff, Tori N Yamamoto, Nicholas P Restifo.
Nat Rev Clin Oncol, 2014 Nov 12; 11(12). PMID: 25384948    Free PMC article.
The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells.
Tessa Gargett, Michael P Brown.
Front Pharmacol, 2014 Nov 13; 5. PMID: 25389405    Free PMC article.
Highly Cited. Review.
Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.
Kevin C Conlon, Enrico Lugli, +20 authors, Thomas A Waldmann.
J Clin Oncol, 2014 Nov 19; 33(1). PMID: 25403209    Free PMC article.
Highly Cited.
Central nervous system involvement in adult acute lymphoblastic leukemia: diagnostic tools, prophylaxis, and therapy.
Maria Ilaria Del Principe, Luca Maurillo, +13 authors, Adriano Venditti.
Mediterr J Hematol Infect Dis, 2014 Nov 20; 6(1). PMID: 25408861    Free PMC article.
Review.
T cell receptor-engineered T cells to treat solid tumors: T cell processing toward optimal T cell fitness.
Cor H J Lamers, Sabine van Steenbergen-Langeveld, +5 authors, Reno Debets.
Hum Gene Ther Methods, 2014 Nov 26; 25(6). PMID: 25423330    Free PMC article.
Blood and marrow transplant clinical trials network state of the Science Symposium 2014.
Frederick R Appelbaum, Claudio Anasetti, +13 authors, Mary M Horowitz.
Biol Blood Marrow Transplant, 2014 Dec 03; 21(2). PMID: 25445636    Free PMC article.
Advances in T-cell therapy for ALL.
Stephan A Grupp.
Best Pract Res Clin Haematol, 2014 Dec 03; 27(3-4). PMID: 25455270    Free PMC article.
Review.
Transplantation in chronic lymphocytic leukemia: does it still matter in the era of novel targeted therapies?
Fabienne McClanahan, John Gribben.
Hematol Oncol Clin North Am, 2014 Dec 03; 28(6). PMID: 25459179    Free PMC article.
Review.
An HSV-2 based oncolytic virus can function as an attractant to guide migration of adoptively transferred T cells to tumor sites.
Xinping Fu, Armando Rivera, Lihua Tao, Xiaoliu Zhang.
Oncotarget, 2014 Dec 03; 6(2). PMID: 25460506    Free PMC article.
T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo.
Xiaojun Tang, Yan Zhou, +4 authors, Zhenqing Feng.
J Biomed Res, 2014 Dec 04; 28(6). PMID: 25469116    Free PMC article.
Cancer Immunotherapy Using γδT Cells: Dealing with Diversity.
Wouter Scheper, Zsolt Sebestyen, Jürgen Kuball.
Front Immunol, 2014 Dec 06; 5. PMID: 25477886    Free PMC article.
Review.
Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia.
Carol O'Hear, Joshua F Heiber, +2 authors, Terrence L Geiger.
Haematologica, 2014 Dec 07; 100(3). PMID: 25480499    Free PMC article.
CIMT 2014: Next waves in cancer immunotherapy--report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany.
Mustafa Diken, Sebastian Boegel, +6 authors, Sebastian Kreiter.
Hum Vaccin Immunother, 2014 Dec 09; 10(10). PMID: 25483671    Free PMC article.
Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+)  CD25(-) and CD8(+) T cells attenuates effector function.
Sidharth S Jha, Nitya G Chakraborty, +2 authors, David I Dorsky.
Immunology, 2014 Dec 17; 145(1). PMID: 25495780    Free PMC article.
Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses.
Yong Chan Kim, Ai-Hong Zhang, +6 authors, David W Scott.
Blood, 2014 Dec 17; 125(7). PMID: 25498909    Free PMC article.
Improving the safety of cell therapy products by suicide gene transfer.
Benjamin S Jones, Lawrence S Lamb, Frederick Goldman, Antonio Di Stasi.
Front Pharmacol, 2014 Dec 17; 5. PMID: 25505885    Free PMC article.
Review.
Clinical application of genetically modified T cells in cancer therapy.
Michael H Kershaw, Jennifer A Westwood, Clare Y Slaney, Phillip K Darcy.
Clin Transl Immunology, 2014 Dec 17; 3(5). PMID: 25505964    Free PMC article.
Review.
Adoptive T-cell therapy: adverse events and safety switches.
Siok-Keen Tey.
Clin Transl Immunology, 2014 Dec 17; 3(6). PMID: 25505965    Free PMC article.
Review.
Novel immunotherapies for hematologic malignancies.
Michelle H Nelson, Chrystal M Paulos.
Immunol Rev, 2014 Dec 17; 263(1). PMID: 25510273    Free PMC article.
Review.
Adoptive immunotherapy for hematological malignancies using T cells gene-modified to express tumor antigen-specific receptors.
Hiroshi Fujiwara.
Pharmaceuticals (Basel), 2014 Dec 18; 7(12). PMID: 25517545    Free PMC article.
Review.
γδ T Cell-Mediated Antibody-Dependent Cellular Cytotoxicity with CD19 Antibodies Assessed by an Impedance-Based Label-Free Real-Time Cytotoxicity Assay.
Ursula Jördis Eva Seidel, Fabian Vogt, +3 authors, Peter Lang.
Front Immunol, 2014 Dec 19; 5. PMID: 25520723    Free PMC article.
Current advances in T-cell-based cancer immunotherapy.
Mingjun Wang, Bingnan Yin, Helen Y Wang, Rong-Fu Wang.
Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524383    Free PMC article.
Review.
Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.
Yuki Aoki, Takashi Watanabe, +17 authors, Fumihiko Ishikawa.
Blood, 2014 Dec 30; 125(6). PMID: 25538041    Free PMC article.
DNAM-1-based chimeric antigen receptors enhance T cell effector function and exhibit in vivo efficacy against melanoma.
Ming-Ru Wu, Tong Zhang, Andre Alcon, Charles L Sentman.
Cancer Immunol Immunother, 2015 Jan 01; 64(4). PMID: 25549845    Free PMC article.
Adoptive cell therapy for sarcoma.
Melinda Mata, Stephen Gottschalk.
Immunotherapy, 2015 Jan 13; 7(1). PMID: 25572477    Free PMC article.
Review.
Modern immunotherapy of adult B-lineage acute lymphoblastic leukemia with monoclonal antibodies and chimeric antigen receptor modified T cells.
Elena Maino, Anna Maria Scattolin, +4 authors, Renato Bassan.
Mediterr J Hematol Infect Dis, 2015 Jan 13; 7(1). PMID: 25574360    Free PMC article.
Review.
Enhancing antitumor efficacy of chimeric antigen receptor T cells through constitutive CD40L expression.
Kevin J Curran, Beatrijs A Seinstra, +6 authors, Renier J Brentjens.
Mol Ther, 2015 Jan 15; 23(4). PMID: 25582824    Free PMC article.
Highly Cited.
Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model.
H Almåsbak, E Walseng, +8 authors, J A Kyte.
Gene Ther, 2015 Feb 06; 22(5). PMID: 25652098
Targeting the tumor vasculature to enhance T cell activity.
Evripidis Lanitis, Melita Irving, George Coukos.
Curr Opin Immunol, 2015 Feb 11; 33. PMID: 25665467    Free PMC article.
Highly Cited. Review.
Using gene therapy to manipulate the immune system in the fight against B-cell leukemias.
Diana C G Bouhassira, Joshua J Thompson, Marco L Davila.
Expert Opin Biol Ther, 2015 Feb 11; 15(3). PMID: 25666545    Free PMC article.
Review.
Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement.
Corey Smith, Grethe Økern, +5 authors, Rajiv Khanna.
Clin Transl Immunology, 2015 Feb 12; 4(1). PMID: 25671129    Free PMC article.
Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells.
B L Levine.
Cancer Gene Ther, 2015 Feb 14; 22(2). PMID: 25675873
Review.
Improving access to novel agents for childhood leukemia.
Weili Sun, Paul S Gaynon, Richard Sposto, Alan S Wayne.
Cancer, 2015 Feb 14; 121(12). PMID: 25678105    Free PMC article.
Review.
Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma.
Laura A Johnson, John Scholler, +26 authors, Marcela V Maus.
Sci Transl Med, 2015 Feb 20; 7(275). PMID: 25696001    Free PMC article.
Highly Cited.
(89)Zr-Oxine Complex PET Cell Imaging in Monitoring Cell-based Therapies.
Noriko Sato, Haitao Wu, +3 authors, Peter L Choyke.
Radiology, 2015 Feb 24; 275(2). PMID: 25706654    Free PMC article.
Re-defining response and treatment effects for neuro-oncology immunotherapy clinical trials.
David A Reardon, Hideho Okada.
J Neurooncol, 2015 Feb 25; 123(3). PMID: 25707876
Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.
Ivan Liadi, Harjeet Singh, +9 authors, Navin Varadarajan.
Cancer Immunol Res, 2015 Feb 26; 3(5). PMID: 25711538    Free PMC article.
Adoptive T cell immunotherapy for cancer.
Karlo Perica, Juan Carlos Varela, Mathias Oelke, Jonathan Schneck.
Rambam Maimonides Med J, 2015 Feb 27; 6(1). PMID: 25717386    Free PMC article.
Review.
Manufacture of tumor- and virus-specific T lymphocytes for adoptive cell therapies.
X Wang, I Rivière.
Cancer Gene Ther, 2015 Feb 28; 22(2). PMID: 25721207    Free PMC article.
Review.
CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia.
S S Kenderian, M Ruella, +9 authors, S Gill.
Leukemia, 2015 Feb 28; 29(8). PMID: 25721896    Free PMC article.
Highly Cited.
Biomarkers for glioma immunotherapy: the next generation.
Jennifer S Sims, Timothy H Ung, +2 authors, Jeffrey N Bruce.
J Neurooncol, 2015 Mar 01; 123(3). PMID: 25724916    Free PMC article.
Review.
Characterization of CD22 expression in acute lymphoblastic leukemia.
Nirali N Shah, Maryalice Stetler Stevenson, +5 authors, Alan S Wayne.
Pediatr Blood Cancer, 2015 Mar 03; 62(6). PMID: 25728039    Free PMC article.
Advantages and applications of CAR-expressing natural killer cells.
Wolfgang Glienke, Ruth Esser, +7 authors, Ulrike Koehl.
Front Pharmacol, 2015 Mar 03; 6. PMID: 25729364    Free PMC article.
Highly Cited. Review.
Improving the outcome for children with cancer: Development of targeted new agents.
Peter C Adamson.
CA Cancer J Clin, 2015 Mar 11; 65(3). PMID: 25754421    Free PMC article.
Review.
The pre-BCR to the rescue: therapeutic targeting of pre-B cell ALL.
Thomas Trimarchi, Iannis Aifantis.
Cancer Cell, 2015 Mar 12; 27(3). PMID: 25759017    Free PMC article.
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma.
Nabil Ahmed, Vita S Brawley, +23 authors, Stephen Gottschalk.
J Clin Oncol, 2015 Mar 25; 33(15). PMID: 25800760    Free PMC article.
Highly Cited.
Mammalian synthetic biology: emerging medical applications.
Zoltán Kis, Hugo Sant'Ana Pereira, +2 authors, Rob Krams.
J R Soc Interface, 2015 Mar 27; 12(106). PMID: 25808341    Free PMC article.
Review.
Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL.
Yongzhi Cui, Masahiro Onozawa, +7 authors, Crystal L Mackall.
Blood, 2015 Mar 31; 125(19). PMID: 25814528    Free PMC article.
Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells.
Sanja Stevanović, Lindsey M Draper, +10 authors, Christian S Hinrichs.
J Clin Oncol, 2015 Apr 01; 33(14). PMID: 25823737    Free PMC article.
Highly Cited.
Pancreatic cancer: from state-of-the-art treatments to promising novel therapies.
Ignacio Garrido-Laguna, Manuel Hidalgo.
Nat Rev Clin Oncol, 2015 Apr 01; 12(6). PMID: 25824606
Highly Cited. Review.
Genetic Engineering of T Cells to Target HERV-K, an Ancient Retrovirus on Melanoma.
Janani Krishnamurthy, Brian A Rabinovich, +9 authors, Laurence J N Cooper.
Clin Cancer Res, 2015 Apr 02; 21(14). PMID: 25829402    Free PMC article.
Novel agents for the treatment of childhood acute leukemia.
Colleen E Annesley, Patrick Brown.
Ther Adv Hematol, 2015 Apr 02; 6(2). PMID: 25830014    Free PMC article.
Review.
Impact of the immune system and immunotherapy in colorectal cancer.
Janet L Markman, Stephen L Shiao.
J Gastrointest Oncol, 2015 Apr 02; 6(2). PMID: 25830040    Free PMC article.
Review.
B7H6-specific chimeric antigen receptors lead to tumor elimination and host antitumor immunity.
M-R Wu, T Zhang, L R DeMars, C L Sentman.
Gene Ther, 2015 Apr 02; 22(8). PMID: 25830550    Free PMC article.
Chimeric antigen receptors and bispecific antibodies to retarget T cells in pediatric oncology.
Maya Suzuki, Kevin J Curran, Nai-Kong V Cheung.
Pediatr Blood Cancer, 2015 Apr 03; 62(8). PMID: 25832831    Free PMC article.
Review.
CMVpp65 Vaccine Enhances the Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV-Specific T Cells.
Xiuli Wang, ChingLam W Wong, +11 authors, Stephen J Forman.
Clin Cancer Res, 2015 Apr 04; 21(13). PMID: 25838392    Free PMC article.
New cell sources for T cell engineering and adoptive immunotherapy.
Maria Themeli, Isabelle Rivière, Michel Sadelain.
Cell Stem Cell, 2015 Apr 07; 16(4). PMID: 25842976    Free PMC article.
Review.
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age.
Hirotake Tsukamoto, Satoru Senju, +2 authors, Yasuharu Nishimura.
Nat Commun, 2015 Apr 08; 6. PMID: 25850032    Free PMC article.
Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T.
Rachel A Burga, Mitchell Thorn, +8 authors, Steven C Katz.
Cancer Immunol Immunother, 2015 Apr 09; 64(7). PMID: 25850344    Free PMC article.
Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases.
Steven C Katz, Rachel A Burga, +11 authors, Richard P Junghans.
Clin Cancer Res, 2015 Apr 09; 21(14). PMID: 25850950    Free PMC article.
Highly Cited.
Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells.
Rachel C Lynn, Mathilde Poussin, +4 authors, Daniel J Powell.
Blood, 2015 Apr 19; 125(22). PMID: 25887778    Free PMC article.
Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor.
Joost H van den Berg, Raquel Gomez-Eerland, +11 authors, John B A G Haanen.
Mol Ther, 2015 Apr 22; 23(9). PMID: 25896248    Free PMC article.
Spatial and functional heterogeneities shape collective behavior of tumor-immune networks.
Daniel K Wells, Yishan Chuang, +3 authors, Joshua N Leonard.
PLoS Comput Biol, 2015 Apr 24; 11(4). PMID: 25905470    Free PMC article.
Toxicities of Immunotherapy for the Practitioner.
Jeffrey S Weber, James C Yang, Michael B Atkins, Mary L Disis.
J Clin Oncol, 2015 Apr 29; 33(18). PMID: 25918278    Free PMC article.
Highly Cited. Review.
CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo.
Patrick J Hanley, Jan J Melenhorst, +16 authors, Catherine M Bollard.
Sci Transl Med, 2015 May 01; 7(285). PMID: 25925682    Free PMC article.
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors.
Adrienne H Long, Waleed M Haso, +12 authors, Crystal L Mackall.
Nat Med, 2015 May 06; 21(6). PMID: 25939063    Free PMC article.
Highly Cited.
Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.
Joal D Beane, Gary Lee, +20 authors, Steven A Feldman.
Mol Ther, 2015 May 06; 23(8). PMID: 25939491    Free PMC article.
Serum HMGB1 is a predictive and prognostic biomarker for oncolytic immunotherapy.
Ilkka Liikanen, Anniina Koski, +6 authors, Akseli Hemminki.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949903    Free PMC article.
Immunotherapy for hepatocellular carcinoma: From basic research to clinical use.
Yu-Peng Hong, Zi-Duo Li, Pankaj Prasoon, Qi Zhang.
World J Hepatol, 2015 May 09; 7(7). PMID: 25954480    Free PMC article.
Review.
From humble beginnings to success in the clinic: Chimeric antigen receptor-modified T-cells and implications for immunotherapy.
Amelia E Firor, Alexander Jares, Yupo Ma.
Exp Biol Med (Maywood), 2015 May 10; 240(8). PMID: 25956686    Free PMC article.
Review.
Risk factors and timing of relapse after allogeneic transplantation in pediatric ALL: for whom and when should interventions be tested?
M A Pulsipher, B Langholz, +10 authors, S A Grupp.
Bone Marrow Transplant, 2015 May 12; 50(9). PMID: 25961775    Free PMC article.
Lentivirus-induced 'Smart' dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma.
B S Sundarasetty, L Chan, +16 authors, R Stripecke.
Gene Ther, 2015 May 13; 22(9). PMID: 25965393    Free PMC article.
Fever and the thermal regulation of immunity: the immune system feels the heat.
Sharon S Evans, Elizabeth A Repasky, Daniel T Fisher.
Nat Rev Immunol, 2015 May 16; 15(6). PMID: 25976513    Free PMC article.
Highly Cited. Review.
Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies.
Asiri Ediriwickrema, W Mark Saltzman.
ACS Biomater Sci Eng, 2015 May 20; 1(2). PMID: 25984571    Free PMC article.
Review.
Orchestrating an immune response against cancer with engineered immune cells expressing αβTCRs, CARs, and innate immune receptors: an immunological and regulatory challenge.
Moniek A de Witte, Guido J J Kierkels, +2 authors, Jürgen Kuball.
Cancer Immunol Immunother, 2015 May 21; 64(7). PMID: 25990073    Free PMC article.
Review.
Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma.
Kimberly A Noonan, Carol A Huff, +16 authors, Ivan Borrello.
Sci Transl Med, 2015 May 23; 7(288). PMID: 25995224    Free PMC article.
Minimal residual disease diagnostics in acute lymphoblastic leukemia: need for sensitive, fast, and standardized technologies.
Jacques J M van Dongen, Vincent H J van der Velden, Monika Brüggemann, Alberto Orfao.
Blood, 2015 May 23; 125(26). PMID: 25999452    Free PMC article.
Highly Cited. Review.
CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia.
Shannon L Maude, David T Teachey, David L Porter, Stephan A Grupp.
Blood, 2015 May 23; 125(26). PMID: 25999455    Free PMC article.
Highly Cited. Review.
Improving the safety of cell therapy with the TK-suicide gene.
Raffaella Greco, Giacomo Oliveira, +9 authors, Fabio Ciceri.
Front Pharmacol, 2015 May 23; 6. PMID: 25999859    Free PMC article.
Review.
Progress and problems with the use of suicide genes for targeted cancer therapy.
Zahra Karjoo, Xuguang Chen, Arash Hatefi.
Adv Drug Deliv Rev, 2015 May 26; 99(Pt A). PMID: 26004498    Free PMC article.
Review.
Profile of elotuzumab and its potential in the treatment of multiple myeloma.
Yi-Chang Liu, Susann Szmania, Frits van Rhee.
Blood Lymphat Cancer, 2015 May 26; 2014(4). PMID: 26005365    Free PMC article.
Allogeneic lymphocyte-licensed DCs expand T cells with improved antitumor activity and resistance to oxidative stress and immunosuppressive factors.
Chuan Jin, Di Yu, +3 authors, Magnus Essand.
Mol Ther Methods Clin Dev, 2014 Jan 01; 1. PMID: 26015949    Free PMC article.
Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations.
Drew C Deniger, Jianqiang Yu, +12 authors, Laurence J N Cooper.
PLoS One, 2015 Jun 02; 10(6). PMID: 26030772    Free PMC article.
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells.
Pamela M Odorizzi, Kristen E Pauken, +2 authors, E John Wherry.
J Exp Med, 2015 Jun 03; 212(7). PMID: 26034050    Free PMC article.
Highly Cited.
T-cell and natural killer cell therapies for hematologic malignancies after hematopoietic stem cell transplantation: enhancing the graft-versus-leukemia effect.
C Russell Cruz, Catherine M Bollard.
Haematologica, 2015 Jun 03; 100(6). PMID: 26034113    Free PMC article.
Review.
Genetically modified T cells in cancer therapy: opportunities and challenges.
Michaela Sharpe, Natalie Mount.
Dis Model Mech, 2015 Jun 03; 8(4). PMID: 26035842    Free PMC article.
Review.
Umbilical cord blood graft engineering: challenges and opportunities.
P A Thompson, K Rezvani, +13 authors, E J Shpall.
Bone Marrow Transplant, 2015 Jun 04; 50 Suppl 2. PMID: 26039209
Review.
Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein.
Haiying Qin, Monica Cho, +15 authors, Terry J Fry.
Blood, 2015 Jun 05; 126(5). PMID: 26041741    Free PMC article.
"Much ado to achieve nothing: prospects for curing HIV infection".
Andrew D Badley.
Mol Cell Ther, 2014 Jan 01; 2. PMID: 26056578    Free PMC article.
Stem cell in alternative treatments for brain tumors: potential for gene delivery.
Veronica Mariotti, Steven J Greco, +2 authors, Pranela Rameshwar.
Mol Cell Ther, 2014 Jan 01; 2. PMID: 26056591    Free PMC article.
Review.
Adoptive T-cell therapy for Leukemia.
Haven R Garber, Asma Mirza, Elizabeth A Mittendorf, Gheath Alatrash.
Mol Cell Ther, 2014 Jan 01; 2. PMID: 26056592    Free PMC article.
Review.
A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy.
Julien Valton, Valérie Guyot, +5 authors, Laurent Poirot.
Mol Ther, 2015 Jun 11; 23(9). PMID: 26061646    Free PMC article.
Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells.
Bonnie Huang, Wuhbet D Abraham, +3 authors, Darrell J Irvine.
Sci Transl Med, 2015 Jun 13; 7(291). PMID: 26062846    Free PMC article.
Highly Cited.
CAR therapy for hematological cancers: can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies?
Hollie J Pegram, Eric L Smith, Sarwish Rafiq, Renier J Brentjens.
Immunotherapy, 2015 Jun 13; 7(5). PMID: 26065479    Free PMC article.
Review.
Natural Killer Cell Immunotherapy: From Bench to Bedside.
Anna Domogala, J Alejandro Madrigal, Aurore Saudemont.
Front Immunol, 2015 Jun 20; 6. PMID: 26089820    Free PMC article.
Review.
Present and Future of Allogeneic Natural Killer Cell Therapy.
Okjae Lim, Mi Young Jung, Yu Kyeong Hwang, Eui-Cheol Shin.
Front Immunol, 2015 Jun 20; 6. PMID: 26089823    Free PMC article.
Review.
Harnessing the Microbiome to Enhance Cancer Immunotherapy.
Michelle H Nelson, Marshall A Diven, Logan W Huff, Chrystal M Paulos.
J Immunol Res, 2015 Jun 24; 2015. PMID: 26101781    Free PMC article.
Review.
A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity.
De-Gang Song, Qunrui Ye, +3 authors, Daniel J Powell.
Oncotarget, 2015 Jun 24; 6(25). PMID: 26101914    Free PMC article.
Impact of a New Fusion Receptor on PD-1-Mediated Immunosuppression in Adoptive T Cell Therapy.
Sebastian Kobold, Simon Grassmann, +10 authors, Simon Rothenfußer.
J Natl Cancer Inst, 2015 Jun 25; 107(8). PMID: 26105028    Free PMC article.
Seatbelts in CAR therapy: How Safe Are CARS?
Kentaro Minagawa, Xiaoou Zhou, Shin Mineishi, Antonio Di Stasi.
Pharmaceuticals (Basel), 2015 Jun 26; 8(2). PMID: 26110321    Free PMC article.
Review.
Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade.
Raymond J Kelleher, Sathy Balu-Iyer, +10 authors, Richard B Bankert.
Cancer Immunol Res, 2015 Jun 27; 3(11). PMID: 26112921    Free PMC article.
T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice.
Heather VanSeggelen, Joanne A Hammill, +6 authors, Jonathan L Bramson.
Mol Ther, 2015 Jul 01; 23(10). PMID: 26122933    Free PMC article.
The pharmacology of second-generation chimeric antigen receptors.
Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain.
Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802    Free PMC article.
Highly Cited. Review.
A bioinformatic framework for immune repertoire diversity profiling enables detection of immunological status.
Victor Greiff, Pooja Bhat, +3 authors, Sai T Reddy.
Genome Med, 2015 Jul 04; 7(1). PMID: 26140055    Free PMC article.
Highly Cited.
Synthetic Nanoparticles for Vaccines and Immunotherapy.
Darrell J Irvine, Melissa C Hanson, Kavya Rakhra, Talar Tokatlian.
Chem Rev, 2015 Jul 15; 115(19). PMID: 26154342    Free PMC article.
Highly Cited. Review.
Are BiTEs the "missing link" in cancer therapy?
Carter M Suryadevara, Patrick C Gedeon, +5 authors, John H Sampson.
Oncoimmunology, 2015 Jul 15; 4(6). PMID: 26155413    Free PMC article.
Review.
CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells.
Jianfeng Han, Jianhong Chu, +15 authors, Jianhua Yu.
Sci Rep, 2015 Jul 15; 5. PMID: 26155832    Free PMC article.
Highly Cited.
Engineering CAR-T cells: Design concepts.
Shivani Srivastava, Stanley R Riddell.
Trends Immunol, 2015 Jul 15; 36(8). PMID: 26169254    Free PMC article.
Highly Cited. Review.
Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street.
David M Barrett, Stephan A Grupp, Carl H June.
J Immunol, 2015 Jul 19; 195(3). PMID: 26188068    Free PMC article.
Highly Cited. Review.
Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation.
Bala Sai Sundarasetty, Stephan Kloess, +14 authors, Renata Stripecke.
J Transl Med, 2015 Jul 23; 13. PMID: 26198406    Free PMC article.
The past, present and future of immunotherapy against tumor.
Tao Jiang, Caicun Zhou.
Transl Lung Cancer Res, 2015 Jul 25; 4(3). PMID: 26207213    Free PMC article.
Review.
Immunotherapy of melanoma.
John B A G Haanen.
EJC Suppl, 2013 Sep 01; 11(2). PMID: 26217118    Free PMC article.
Review.
Editorial: 21st Century Storm Chasers: Defining Macrophage Activation Syndrome.
Scott W Canna, Peter A Nigrovic.
Arthritis Rheumatol, 2015 Sep 01; 68(3). PMID: 26314501    Free PMC article.
Vaccines, Adjuvants, and Dendritic Cell Activators--Current Status and Future Challenges.
Joseph Obeid, Yinin Hu, Craig L Slingluff.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320060    Free PMC article.
Review.
Immune Modulation in Hematologic Malignancies.
Madhav V Dhodapkar, Kavita M Dhodapkar.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320065    Free PMC article.
Review.
Cancer immunotherapy: harnessing the immune system to battle cancer.
Yiping Yang.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325031    Free PMC article.
Highly Cited. Review.
CAR therapy: the CD19 paradigm.
Michel Sadelain.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325036    Free PMC article.
Highly Cited. Review.
Adoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptors.
Maël Heiblig, Mohamed Elhamri, Mauricette Michallet, Xavier Thomas.
World J Stem Cells, 2015 Sep 04; 7(7). PMID: 26328018    Free PMC article.
Review.
Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity.
Hillary G Caruso, Lenka V Hurton, +11 authors, Laurence J N Cooper.
Cancer Res, 2015 Sep 04; 75(17). PMID: 26330164    Free PMC article.
Highly Cited.
CAR-T Cell Therapy for Lymphoma.
Carlos A Ramos, Helen E Heslop, Malcolm K Brenner.
Annu Rev Med, 2015 Sep 04; 67. PMID: 26332003    Free PMC article.
Review.
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia.
David L Porter, Wei-Ting Hwang, +15 authors, Carl H June.
Sci Transl Med, 2015 Sep 04; 7(303). PMID: 26333935    Free PMC article.
Highly Cited.
Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site.
Maxime Thoreau, HweiXian Leong Penny, +10 authors, Nadège Bercovici.
Oncotarget, 2015 Sep 05; 6(29). PMID: 26337837    Free PMC article.
Immunotherapy for Multiple Myeloma, Past, Present, and Future: Monoclonal Antibodies, Vaccines, and Cellular Therapies.
Rebecca Karp Leaf, Hearn Jay Cho, David Avigan.
Curr Hematol Malig Rep, 2015 Sep 05; 10(4). PMID: 26338470
Review.
Cancer targeted therapeutics: From molecules to drug delivery vehicles.
Daxing Liu, Debra T Auguste.
J Control Release, 2015 Sep 08; 219. PMID: 26342659    Free PMC article.
Smart CARs engineered for cancer immunotherapy.
Saul J Priceman, Stephen J Forman, Christine E Brown.
Curr Opin Oncol, 2015 Sep 10; 27(6). PMID: 26352543    Free PMC article.
Review.
Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma.
Alfred L Garfall, Marcela V Maus, +13 authors, Edward A Stadtmauer.
N Engl J Med, 2015 Sep 10; 373(11). PMID: 26352815    Free PMC article.
Highly Cited.
Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor.
Keith Schutsky, D Gang Song, +5 authors, Daniel J Powell.
Oncotarget, 2015 Sep 12; 6(30). PMID: 26359629    Free PMC article.
Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo.
D Sommermeyer, M Hudecek, +4 authors, S R Riddell.
Leukemia, 2015 Sep 16; 30(2). PMID: 26369987    Free PMC article.
Highly Cited.
Targeting B-cell maturation antigen in multiple myeloma.
Yu-Tzu Tai, Kenneth C Anderson.
Immunotherapy, 2015 Sep 16; 7(11). PMID: 26370838    Free PMC article.
Review.
Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysis.
Tengfei Zhang, Ling Cao, +10 authors, Yi Zhang.
Oncotarget, 2015 Sep 18; 6(32). PMID: 26376680    Free PMC article.
Chimeric Antigen Receptor T Cell Therapy in Hematology.
Pınar Ataca, Önder Arslan.
Turk J Haematol, 2015 Sep 18; 32(4). PMID: 26377367    Free PMC article.
Review.
Blinatumomab for the treatment of acute lymphoblastic leukemia.
Jason B Kaplan, Marina Grischenko, Francis J Giles.
Invest New Drugs, 2015 Sep 19; 33(6). PMID: 26383529
Review.
Lymphoma Immunotherapy: Current Status.
Roberta Zappasodi, Filippo de Braud, Massimo Di Nicola.
Front Immunol, 2015 Sep 22; 6. PMID: 26388871    Free PMC article.
Review.
Challenges and opportunities of allogeneic donor-derived CAR T cells.
Yinmeng Yang, Elad Jacoby, Terry J Fry.
Curr Opin Hematol, 2015 Sep 22; 22(6). PMID: 26390167    Free PMC article.
Review.
Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.
Chia-Yung Wu, Kole T Roybal, +2 authors, Wendell A Lim.
Science, 2015 Sep 26; 350(6258). PMID: 26405231    Free PMC article.
Highly Cited.
Intratumoral oncolytic adenoviral treatment modulates the glioma microenvironment and facilitates systemic tumor-antigen-specific T cell therapy.
Jian Qiao, Mahua Dey, +7 authors, Maciej S Lesniak.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405578    Free PMC article.
T cell engineering as therapy for cancer and HIV: our synthetic future.
Carl H June, Bruce L Levine.
Philos Trans R Soc Lond B Biol Sci, 2015 Sep 30; 370(1680). PMID: 26416683    Free PMC article.
Review.
Potentiality of immunotherapy against hepatocellular carcinoma.
Nobuhiro Tsuchiya, Yu Sawada, +2 authors, Tetsuya Nakatsura.
World J Gastroenterol, 2015 Oct 01; 21(36). PMID: 26420958    Free PMC article.
Review.
CD19-redirected chimeric antigen receptor-modified T cells: a promising immunotherapy for children and adults with B-cell acute lymphoblastic leukemia (ALL).
Sarah K Tasian, Rebecca A Gardner.
Ther Adv Hematol, 2015 Oct 02; 6(5). PMID: 26425336    Free PMC article.
Review.
Adoptive T-Cell Immunotherapy.
Stephen Gottschalk, Cliona M Rooney.
Curr Top Microbiol Immunol, 2015 Oct 03; 391. PMID: 26428384    Free PMC article.
Review.
Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers.
Shibani Pati, Marcello Pilia, +5 authors, Todd E Rasmussen.
Shock, 2015 Oct 03; 44(6). PMID: 26428845    Free PMC article.
Review.
Strain-dependent Lethal Toxicity in NKG2D Ligand-targeted CAR T-cell Therapy.
Rachel C Lynn, Daniel J Powell.
Mol Ther, 2015 Oct 08; 23(10). PMID: 26442803    Free PMC article.
Progress and prospects of gene therapy clinical trials for the muscular dystrophies.
Niclas E Bengtsson, Jane T Seto, +2 authors, Guy L Odom.
Hum Mol Genet, 2015 Oct 10; 25(R1). PMID: 26450518    Free PMC article.
Review.
Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia.
Hanren Dai, Wenying Zhang, +14 authors, Weidong Han.
Oncoimmunology, 2015 Oct 10; 4(11). PMID: 26451310    Free PMC article.
Highly Cited.
An Update on the Role of Immunotherapy and Vaccine Strategies for Primary Brain Tumors.
Martha R Neagu, David A Reardon.
Curr Treat Options Oncol, 2015 Oct 12; 16(11). PMID: 26454859
Review.
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.
Zeguo Zhao, Maud Condomines, +5 authors, Michel Sadelain.
Cancer Cell, 2015 Oct 16; 28(4). PMID: 26461090    Free PMC article.
Highly Cited.
Immunotherapy and tumor microenvironment.
Haidong Tang, Jian Qiao, Yang-Xin Fu.
Cancer Lett, 2015 Oct 20; 370(1). PMID: 26477683    Free PMC article.
Highly Cited. Review.
Fast Cars and No Brakes: Autologous Stem Cell Transplantation as a Platform for Novel Immunotherapies.
Miguel-Angel Perales, Craig S Sauter, Philippe Armand.
Biol Blood Marrow Transplant, 2015 Oct 21; 22(1). PMID: 26485445    Free PMC article.
Review.
Minimal residual disease assessed by multi-parameter flow cytometry is highly prognostic in adult patients with acute lymphoblastic leukaemia.
Farhad Ravandi, Jeffrey L Jorgensen, +19 authors, Hagop M Kantarjian.
Br J Haematol, 2015 Oct 23; 172(3). PMID: 26492205    Free PMC article.
Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy.
Xiang-Jun Tang, Xu-Yong Sun, +7 authors, Jie Luo.
Oncotarget, 2015 Oct 27; 6(42). PMID: 26496034    Free PMC article.
Review.
Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors.
Aurore Morello, Michel Sadelain, Prasad S Adusumilli.
Cancer Discov, 2015 Oct 28; 6(2). PMID: 26503962    Free PMC article.
Highly Cited. Review.
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.
Elena Sotillo, David M Barrett, +27 authors, Andrei Thomas-Tikhonenko.
Cancer Discov, 2015 Nov 01; 5(12). PMID: 26516065    Free PMC article.
Highly Cited.
Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy.
David A Reardon, Mark R Gilbert, Wolfgang Wick, Linda Liau.
Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516225    Free PMC article.
Review.
Progress and challenges in viral vector manufacturing.
Johannes C M van der Loo, J Fraser Wright.
Hum Mol Genet, 2015 Nov 01; 25(R1). PMID: 26519140    Free PMC article.
Review.
Novel immunotherapies in lymphoid malignancies.
Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes.
Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683    Free PMC article.
Highly Cited. Review.
Preclinical targeting of human T-cell malignancies using CD4-specific chimeric antigen receptor (CAR)-engineered T cells.
K Pinz, H Liu, +8 authors, Y Ma.
Leukemia, 2015 Nov 04; 30(3). PMID: 26526988
Potential therapeutic strategy for gastric cancer peritoneal metastasis by NKG2D ligands-specific T cells.
Xianqiang Liu, Meili Sun, +3 authors, Huan Shi.
Onco Targets Ther, 2015 Nov 07; 8. PMID: 26543378    Free PMC article.
Immunotherapy response assessment in neuro-oncology: a report of the RANO working group.
Hideho Okada, Michael Weller, +16 authors, David A Reardon.
Lancet Oncol, 2015 Nov 08; 16(15). PMID: 26545842    Free PMC article.
Highly Cited. Review.
T-cell receptor gene therapy--ready to go viral?
Terhi Karpanen, Johanna Olweus.
Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548533    Free PMC article.
Review.
CAR T-cell immunotherapy: The path from the by-road to the freeway?
Lynsey M Whilding, John Maher.
Mol Oncol, 2015 Nov 14; 9(10). PMID: 26563646    Free PMC article.
Review.
A Perspective of Immunotherapy for Breast Cancer: Lessons Learned and Forward Directions for All Cancers.
George R Nahas, Nykia D Walker, Margarette Bryan, Pranela Rameshwar.
Breast Cancer (Auckl), 2015 Nov 17; 9(Suppl 2). PMID: 26568682    Free PMC article.
Review.
Therapies on the horizon for childhood acute lymphoblastic leukemia.
William L Carroll, Stephen P Hunger.
Curr Opin Pediatr, 2015 Nov 18; 28(1). PMID: 26576011    Free PMC article.
Review.
Designing CAR T cells for glioblastoma.
Marcela V Maus.
Oncoimmunology, 2015 Nov 21; 4(12). PMID: 26587317    Free PMC article.
CAR-T cells are serial killers.
Alexander J Davenport, Misty R Jenkins, +5 authors, Paul J Neeson.
Oncoimmunology, 2015 Nov 21; 4(12). PMID: 26587330    Free PMC article.
Cellular and Antibody Based Approaches for Pediatric Cancer Immunotherapy.
Michael A Huang, Deepa K Krishnadas, Kenneth G Lucas.
J Immunol Res, 2015 Nov 21; 2015. PMID: 26587548    Free PMC article.
Review.
CD19-Targeted T Cells for Hematologic Malignancies: Clinical Experience to Date.
Marco L Davila, Craig Sauter, Renier Brentjens.
Cancer J, 2015 Nov 21; 21(6). PMID: 26588678    Free PMC article.
Review.
Toxicities Associated With Adoptive T-Cell Transfer for Cancer.
James C Yang.
Cancer J, 2015 Nov 21; 21(6). PMID: 26588684    Free PMC article.
Review.
Combination cancer immunotherapies tailored to the tumour microenvironment.
Mark J Smyth, Shin Foong Ngiow, Antoni Ribas, Michele W L Teng.
Nat Rev Clin Oncol, 2015 Nov 26; 13(3). PMID: 26598942
Highly Cited. Review.
Tailoring the Treatment of Melanoma: Implications for Personalized Medicine.
Linna Duan, Eric M Mukherjee, Deepak Narayan.
Yale J Biol Med, 2015 Nov 26; 88(4). PMID: 26604863    Free PMC article.
Review.
Adoptive T-cell therapies for refractory/relapsed leukemia and lymphoma: current strategies and recent advances.
Lauren McLaughlin, C Russell Cruz, Catherine M Bollard.
Ther Adv Hematol, 2015 Dec 02; 6(6). PMID: 26622998    Free PMC article.
Review.
The Application of Natural Killer Cell Immunotherapy for the Treatment of Cancer.
Katayoun Rezvani, Rayne H Rouce.
Front Immunol, 2015 Dec 05; 6. PMID: 26635792    Free PMC article.
Highly Cited. Review.
Improvement of overall survival after allogeneic hematopoietic stem cell transplantation for children and adolescents: a three-decade experience of a single institution.
E Brissot, F Rialland, +12 authors, M Mohty.
Bone Marrow Transplant, 2015 Dec 08; 51(2). PMID: 26642337
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Bennett G Childs, Matej Durik, Darren J Baker, Jan M van Deursen.
Nat Med, 2015 Dec 10; 21(12). PMID: 26646499    Free PMC article.
Highly Cited. Review.
Coexpressed Catalase Protects Chimeric Antigen Receptor-Redirected T Cells as well as Bystander Cells from Oxidative Stress-Induced Loss of Antitumor Activity.
Maarten A Ligtenberg, Dimitrios Mougiakakos, +6 authors, Rolf Kiessling.
J Immunol, 2015 Dec 18; 196(2). PMID: 26673145    Free PMC article.
Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors.
Joanne A Hammill, Heather VanSeggelen, +5 authors, Jonathan L Bramson.
J Immunother Cancer, 2015 Dec 18; 3. PMID: 26673402    Free PMC article.
Molecular profiling of childhood cancer: Biomarkers and novel therapies.
Federica Saletta, Carol Wadham, +5 authors, Jennifer A Byrne.
BBA Clin, 2014 Jun 01; 1. PMID: 26675306    Free PMC article.
Review.
Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors.
Hannah Karlsson, Emma Svensson, +5 authors, Angelica Loskog.
PLoS One, 2015 Dec 25; 10(12). PMID: 26700307    Free PMC article.
Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice.
Yuho Najima, Mariko Tomizawa-Murasawa, +9 authors, Fumihiko Ishikawa.
Blood, 2015 Dec 25; 127(6). PMID: 26702062    Free PMC article.
Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors.
Daniel T Harris, David M Kranz.
Trends Pharmacol Sci, 2015 Dec 26; 37(3). PMID: 26705086    Free PMC article.
Review.
Serial Activation of the Inducible Caspase 9 Safety Switch After Human Stem Cell Transplantation.
Xiaoou Zhou, Swati Naik, +3 authors, Malcolm K Brenner.
Mol Ther, 2015 Dec 29; 24(4). PMID: 26708005    Free PMC article.
Prospects for gene-engineered T cell immunotherapy for solid cancers.
Christopher A Klebanoff, Steven A Rosenberg, Nicholas P Restifo.
Nat Med, 2016 Jan 07; 22(1). PMID: 26735408    Free PMC article.
Highly Cited.
Design of chimeric antigen receptors with integrated controllable transient functions.
Alexandre Juillerat, Alan Marechal, +4 authors, Philippe Duchateau.
Sci Rep, 2016 Jan 12; 6. PMID: 26750734    Free PMC article.
Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma.
Andreas Viardot, Marie-Elisabeth Goebeler, +10 authors, Ralf C Bargou.
Blood, 2016 Jan 13; 127(11). PMID: 26755709    Free PMC article.
Highly Cited.
Versatile strategy for controlling the specificity and activity of engineered T cells.
Jennifer S Y Ma, Ji Young Kim, +14 authors, Yu Cao.
Proc Natl Acad Sci U S A, 2016 Jan 14; 113(4). PMID: 26759368    Free PMC article.
Highly Cited.
Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.
David T Rodgers, Magdalena Mazagova, +15 authors, Travis S Young.
Proc Natl Acad Sci U S A, 2016 Jan 14; 113(4). PMID: 26759369    Free PMC article.
Highly Cited.
Novel technologies and emerging biomarkers for personalized cancer immunotherapy.
Jianda Yuan, Priti S Hegde, +16 authors, Bernard A Fox.
J Immunother Cancer, 2016 Jan 21; 4. PMID: 26788324    Free PMC article.
Highly Cited. Review.
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia.
Joseph A Fraietta, Kyle A Beckwith, +24 authors, Marcela V Maus.
Blood, 2016 Jan 28; 127(9). PMID: 26813675    Free PMC article.
Highly Cited.
Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy.
Hanren Dai, Yao Wang, Xuechun Lu, Weidong Han.
J Natl Cancer Inst, 2016 Jan 29; 108(7). PMID: 26819347    Free PMC article.
Highly Cited. Review.
Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis.
Rupali Das, Peng Guan, +10 authors, Kim E Nichols.
Blood, 2016 Jan 31; 127(13). PMID: 26825707    Free PMC article.
Highly Cited.
Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.
Leonardo Morsut, Kole T Roybal, +4 authors, Wendell A Lim.
Cell, 2016 Feb 03; 164(4). PMID: 26830878    Free PMC article.
Highly Cited.
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.
Kole T Roybal, Levi J Rupp, +4 authors, Wendell A Lim.
Cell, 2016 Feb 03; 164(4). PMID: 26830879    Free PMC article.
Highly Cited.
Novel immunotherapeutic approaches for the treatment of acute leukemia (myeloid and lymphoblastic).
Kazusa Ishii, Austin J Barrett.
Ther Adv Hematol, 2016 Feb 03; 7(1). PMID: 26834952    Free PMC article.
Review.
Advances in paediatric cancer treatment.
Federica Saletta, Michaela S Seng, Loretta M S Lau.
Transl Pediatr, 2014 Apr 01; 3(2). PMID: 26835334    Free PMC article.
Review.
Construction of a new anti-CD19 chimeric antigen receptor and the anti-leukemia function study of the transduced T cells.
Na An, Zhongfei Tao, +6 authors, Jianxiang Wang.
Oncotarget, 2016 Feb 04; 7(9). PMID: 26840021    Free PMC article.
The Promise of Chimeric Antigen Receptor Engineered T Cells in the Treatment of Hematologic Malignancies.
Sarah J Nagle, Alfred L Garfall, Edward A Stadtmauer.
Cancer J, 2016 Feb 04; 22(1). PMID: 26841014    Free PMC article.
Review.
Generating Peripheral Blood Derived Lymphocytes Reacting Against Autologous Primary AML Blasts.
Rohtesh S Mehta, Xiaohua Chen, +2 authors, Paul Szabolcs.
J Immunother, 2016 Feb 06; 39(2). PMID: 26849076    Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Review.
Immunotherapy in Chronic Lymphocytic Leukaemia (CLL).
Ciara L Freeman, John G Gribben.
Curr Hematol Malig Rep, 2016 Feb 10; 11(1). PMID: 26857283    Free PMC article.
Review.
Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers.
D P Granados, A Rodenbrock, +12 authors, C Perreault.
Leukemia, 2016 Feb 10; 30(6). PMID: 26857467
Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma.
Esther Drent, Richard W J Groen, +11 authors, Tuna Mutis.
Haematologica, 2016 Feb 10; 101(5). PMID: 26858358    Free PMC article.
Chimeric antigen receptor-engineered T cells in CLL: the next chapter unfolds.
Michael Kalos.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885367    Free PMC article.
Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning.
Michelle H Nelson, Jacob S Bowers, +7 authors, Chrystal M Paulos.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885368    Free PMC article.
High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity.
R C Lynn, Y Feng, +4 authors, D J Powell.
Leukemia, 2016 Feb 24; 30(6). PMID: 26898190    Free PMC article.
Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression.
Ying Zhang, Hildegund C J Ertl.
Front Immunol, 2016 Feb 24; 7. PMID: 26904023    Free PMC article.
Review.
IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.
Peter S Kim, Anna R Kwilas, +5 authors, James W Hodge.
Oncotarget, 2016 Feb 26; 7(13). PMID: 26910920    Free PMC article.
Highly Cited.
Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities.
K M Morrissey, T M Yuraszeck, +2 authors, S Kasichayanula.
Clin Transl Sci, 2016 Mar 01; 9(2). PMID: 26924066    Free PMC article.
Highly Cited. Review.
Potential for bispecific T-cell engagers: role of blinatumomab in acute lymphoblastic leukemia.
Caroline Le Jeune, Xavier Thomas.
Drug Des Devel Ther, 2016 Mar 05; 10. PMID: 26937176    Free PMC article.
Review.
T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma.
Nathan Singh, Irina Kulikovskaya, +7 authors, Stephan A Grupp.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942053    Free PMC article.
Comparison of naïve and central memory derived CD8+ effector cell engraftment fitness and function following adoptive transfer.
Xiuli Wang, ChingLam W Wong, +9 authors, Michael C Jensen.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942092    Free PMC article.
Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection.
Eugene A Zhukovsky, Richard J Morse, Marcela V Maus.
Curr Opin Immunol, 2016 Mar 11; 40. PMID: 26963133    Free PMC article.
Review.
Mesothelin as a target for chimeric antigen receptor-modified T cells as anticancer therapy.
Mark O'Hara, Caitlin Stashwick, Andrew R Haas, Janos L Tanyi.
Immunotherapy, 2016 Mar 15; 8(4). PMID: 26973126    Free PMC article.
Review.
A primer on tumour immunology and prostate cancer immunotherapy.
Runhan Ren, Madhuri Koti, +5 authors, D Robert Siemens.
Can Urol Assoc J, 2016 Mar 16; 10(1-2). PMID: 26977209    Free PMC article.
Review.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors.
Xiaojun Liu, Raghuveer Ranganathan, +8 authors, Edmund K Moon.
Cancer Res, 2016 Mar 17; 76(6). PMID: 26979791    Free PMC article.
Highly Cited.
Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials.
Holbrook E Kohrt, Paul C Tumeh, +33 authors, Cancer Immunotherapy Trials Network (CITN).
J Immunother Cancer, 2016 Mar 17; 4. PMID: 26981245    Free PMC article.
Review.
Driving CAR T-cells forward.
Hollie J Jackson, Sarwish Rafiq, Renier J Brentjens.
Nat Rev Clin Oncol, 2016 Mar 24; 13(6). PMID: 27000958    Free PMC article.
Highly Cited. Review.
CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies.
Annette Romanski, Christoph Uherek, +5 authors, Torsten Tonn.
J Cell Mol Med, 2016 Mar 24; 20(7). PMID: 27008316    Free PMC article.
Highly Cited.
Paediatric non-Hodgkin lymphoma - perspectives in translational biology.
Bruce Shiramizu, Lara Mussolin, Wilhelm Woessmann, Wolfram Klapper.
Br J Haematol, 2016 Mar 25; 173(4). PMID: 27009921    Free PMC article.
Review.
Leveraging immunotherapy for the treatment of gynecologic cancers in the era of precision medicine.
Dmitriy Zamarin, Amir A Jazaeri.
Gynecol Oncol, 2016 Mar 27; 141(1). PMID: 27016233    Free PMC article.
Review.
GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade.
Tessa Gargett, Wenbo Yu, +6 authors, Michael P Brown.
Mol Ther, 2016 Mar 30; 24(6). PMID: 27019998    Free PMC article.
Highly Cited.
Chimeric antigen receptor-modified T cells strike back.
Matthew J Frigault, Marcela V Maus.
Int Immunol, 2016 Mar 30; 28(7). PMID: 27021308    Free PMC article.
Review.
An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers.
Simon Thomas, Karin Straathof, +2 authors, Martin Pule.
PLoS One, 2016 Apr 01; 11(3). PMID: 27030986    Free PMC article.
Cell and gene therapy strategies to eradicate HIV reservoirs.
Chelsea Spragg, Harshana De Silva Feelixge, Keith R Jerome.
Curr Opin HIV AIDS, 2016 Apr 01; 11(4). PMID: 27031009    Free PMC article.
Review.
Molecular Pathways: Breaking the Epithelial Cancer Barrier for Chimeric Antigen Receptor and T-cell Receptor Gene Therapy.
Christian S Hinrichs.
Clin Cancer Res, 2016 Apr 03; 22(7). PMID: 27037253    Free PMC article.
Review.
Improving therapy of chronic lymphocytic leukemia with chimeric antigen receptor T cells.
Joseph A Fraietta, Robert D Schwab, Marcela V Maus.
Semin Oncol, 2016 Apr 05; 43(2). PMID: 27040708    Free PMC article.
Review.
Augmentation of CAR T-cell Trafficking and Antitumor Efficacy by Blocking Protein Kinase A Localization.
Kheng Newick, Shaun O'Brien, +6 authors, Steven M Albelda.
Cancer Immunol Res, 2016 Apr 06; 4(6). PMID: 27045023    Free PMC article.
Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy.
Fang Chen, David T Teachey, +7 authors, Simon F Lacey.
J Immunol Methods, 2016 Apr 07; 434. PMID: 27049586    Free PMC article.
A genome editing primer for the hematologist.
Megan D Hoban, Daniel E Bauer.
Blood, 2016 Apr 08; 127(21). PMID: 27053532    Free PMC article.
Review.
BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance.
J Weiland, D Pal, +8 authors, A Elder.
Leukemia, 2016 Apr 09; 30(9). PMID: 27055873    Free PMC article.
Are chimeric antigen receptor T cells ready for prime time?
Renier J Brentjens.
Clin Adv Hematol Oncol, 2016 Apr 09; 14(1). PMID: 27057662    Free PMC article.
T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells.
Eugenia Zah, Meng-Yin Lin, +2 authors, Yvonne Y Chen.
Cancer Immunol Res, 2016 Apr 10; 4(6). PMID: 27059623    Free PMC article.
Highly Cited.
CAR-T Cell Therapies From the Transfusion Medicine Perspective.
Andrew Fesnak, ChieYu Lin, Don L Siegel, Marcela V Maus.
Transfus Med Rev, 2016 Apr 14; 30(3). PMID: 27067907    Free PMC article.
Review.
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.
David T Teachey, Simon F Lacey, +23 authors, Stephan A Grupp.
Cancer Discov, 2016 Apr 15; 6(6). PMID: 27076371    Free PMC article.
Highly Cited.
Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies.
K Roellecke, E L Virts, +11 authors, H Hanenberg.
Gene Ther, 2016 Apr 20; 23(7). PMID: 27092941
Molecular therapeutics in pancreas cancer.
Vignesh Narayanan, Colin D Weekes.
World J Gastrointest Oncol, 2016 Apr 21; 8(4). PMID: 27096032    Free PMC article.
Review.
CAR T Cell Therapy in Acute Lymphoblastic Leukemia and Potential for Chronic Lymphocytic Leukemia.
Nathan Singh, Noelle V Frey, Stephan A Grupp, Shannon L Maude.
Curr Treat Options Oncol, 2016 Apr 22; 17(6). PMID: 27098534
Review.
Novel Therapeutic Strategies in Acute Lymphoblastic Leukemia.
Ajoy Dias, Saad J Kenderian, Gustavo F Westin, Mark R Litzow.
Curr Hematol Malig Rep, 2016 Apr 22; 11(4). PMID: 27101015
Review.
Superior Therapeutic Index in Lymphoma Therapy: CD30(+) CD34(+) Hematopoietic Stem Cells Resist a Chimeric Antigen Receptor T-cell Attack.
Andreas A Hombach, André Görgens, +4 authors, Hinrich Abken.
Mol Ther, 2016 Apr 27; 24(8). PMID: 27112062    Free PMC article.
Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL.
Xiuli Wang, Leslie L Popplewell, +19 authors, Stephen J Forman.
Blood, 2016 Apr 28; 127(24). PMID: 27118452    Free PMC article.
Highly Cited.
GIFT4 fusokine converts leukemic B cells into immune helper cells.
Jiusheng Deng, Andrea Pennati, +5 authors, Jacques Galipeau.
J Transl Med, 2016 Apr 28; 14(1). PMID: 27118475    Free PMC article.
Strategies to genetically engineer T cells for cancer immunotherapy.
Timothy T Spear, Kaoru Nagato, Michael I Nishimura.
Cancer Immunol Immunother, 2016 May 04; 65(6). PMID: 27138532    Free PMC article.
Review.
Medical management of side effects related to CAR T cell therapy in hematologic malignancies.
Manjusha Namuduri, Renier J Brentjens.
Expert Rev Hematol, 2016 May 04; 9(6). PMID: 27139507    Free PMC article.
In Situ immunization by bispecific antibody targeted T cell therapy in breast cancer.
Archana Thakur, Lawrence G Lum.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141330    Free PMC article.
Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer.
Yu Cao, David T Rodgers, +17 authors, Travis S Young.
Angew Chem Int Ed Engl, 2016 May 05; 55(26). PMID: 27145250    Free PMC article.
Epigenetic suppression of the antitumor cytotoxicity of NK cells by histone deacetylase inhibitor valproic acid.
Xiumin Shi, Min Li, +9 authors, Haofan Jin.
Am J Cancer Res, 2016 May 07; 6(3). PMID: 27152238    Free PMC article.
A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.
Carmen S M Yong, Liza B John, +5 authors, Michael H Kershaw.
Oncotarget, 2016 May 07; 7(23). PMID: 27153556    Free PMC article.
Enhanced ADCC and NK Cell Activation of an Anticarcinoma Bispecific Antibody by Genetic Insertion of a Modified IL-15 Cross-linker.
Joerg U Schmohl, Martin Felices, +2 authors, Daniel A Vallera.
Mol Ther, 2016 May 10; 24(7). PMID: 27157665    Free PMC article.
How Chimeric Antigen Receptor Design Affects Adoptive T Cell Therapy.
Albert T Gacerez, Benjamine Arellano, Charles L Sentman.
J Cell Physiol, 2016 May 11; 231(12). PMID: 27163336    Free PMC article.
Review.
Redirecting T-Cell Specificity to EGFR Using mRNA to Self-limit Expression of Chimeric Antigen Receptor.
Hillary G Caruso, Hiroki Torikai, +9 authors, Laurence J N Cooper.
J Immunother, 2016 May 11; 39(5). PMID: 27163741    Free PMC article.
Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside.
Julien Fleurence, Denis Cochonneau, +8 authors, Stéphane Birklé.
Oncotarget, 2016 May 14; 7(27). PMID: 27172791    Free PMC article.
All-trans retinoic acid and interferon-α increase CD38 expression on adult T-cell leukemia cells and sensitize them to T cells bearing anti-CD38 chimeric antigen receptors.
K Mihara, T Yoshida, +6 authors, T Ichinohe.
Blood Cancer J, 2016 May 14; 6. PMID: 27176797    Free PMC article.
CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo.
Gengwen Tian, Amy N Courtney, +10 authors, Leonid S Metelitsa.
J Clin Invest, 2016 May 18; 126(6). PMID: 27183388    Free PMC article.
Highly Cited.
Microfluidic models for adoptive cell-mediated cancer immunotherapies.
Giulia Adriani, Andrea Pavesi, +3 authors, Roger D Kamm.
Drug Discov Today, 2016 May 18; 21(9). PMID: 27185084    Free PMC article.
Review.
CD19 chimeric antigen receptor (CD19 CAR)-redirected adoptive T-cell immunotherapy for the treatment of relapsed or refractory B-cell Non-Hodgkin's Lymphomas.
Alexandra S Onea, Ali R Jazirehi.
Am J Cancer Res, 2016 May 18; 6(2). PMID: 27186412    Free PMC article.
Review.
Adoptive immunotherapy against ovarian cancer.
Gloria Mittica, Sonia Capellero, +4 authors, Giorgio Valabrega.
J Ovarian Res, 2016 May 18; 9(1). PMID: 27188274    Free PMC article.
Review.
Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer.
Chuan Jin, Grammatiki Fotaki, +3 authors, Di Yu.
EMBO Mol Med, 2016 May 18; 8(7). PMID: 27189167    Free PMC article.
Emerging nanotechnologies for cancer immunotherapy.
Sourabh Shukla, Nicole F Steinmetz.
Exp Biol Med (Maywood), 2016 May 18; 241(10). PMID: 27190253    Free PMC article.
Review.
Preserved Activity of CD20-Specific Chimeric Antigen Receptor-Expressing T Cells in the Presence of Rituximab.
Gregory A Rufener, Oliver W Press, +10 authors, Brian G Till.
Cancer Immunol Res, 2016 May 20; 4(6). PMID: 27197068    Free PMC article.
Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors.
Hiroki Torikai, Laurence Jn Cooper.
Mol Ther, 2016 May 21; 24(7). PMID: 27203439    Free PMC article.
Review.
Toxicities of chimeric antigen receptor T cells: recognition and management.
Jennifer N Brudno, James N Kochenderfer.
Blood, 2016 May 22; 127(26). PMID: 27207799    Free PMC article.
Highly Cited. Review.
Scientific Achievements May Not Reach Everyone: Understanding Disparities in Acute Leukemia.
Manali I Patel.
Curr Hematol Malig Rep, 2016 May 23; 11(4). PMID: 27209407
Review.
Myeloid cells in peripheral blood mononuclear cell concentrates inhibit the expansion of chimeric antigen receptor T cells.
David F Stroncek, Jiaqiang Ren, +6 authors, Crystal L Mackall.
Cytotherapy, 2016 May 24; 18(7). PMID: 27210719    Free PMC article.
Integration of Chinese Herbal Medicine Therapy Improves Survival of Patients With Chronic Lymphocytic Leukemia: A Nationwide Population-Based Cohort Study.
Tom Fleischer, Tung-Ti Chang, +3 authors, Hung-Rong Yen.
Medicine (Baltimore), 2016 May 27; 95(21). PMID: 27227953    Free PMC article.
Landscape of tumor-infiltrating T cell repertoire of human cancers.
Bo Li, Taiwen Li, +12 authors, X Shirley Liu.
Nat Genet, 2016 May 31; 48(7). PMID: 27240091    Free PMC article.
Highly Cited.
CD133, Selectively Targeting the Root of Cancer.
Jörg U Schmohl, Daniel A Vallera.
Toxins (Basel), 2016 May 31; 8(6). PMID: 27240402    Free PMC article.
Review.
Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy.
Kamalakannan Rajasekaran, Matthew J Riese, +4 authors, Subramaniam Malarkannan.
Front Immunol, 2016 Jun 01; 7. PMID: 27242783    Free PMC article.
Review.
The role of blinatumomab in patients with relapsed/refractory acute lymphoblastic leukemia.
Jonathan E Benjamin, Anthony S Stein.
Ther Adv Hematol, 2016 Jun 02; 7(3). PMID: 27247755    Free PMC article.
Review.
Clinical development of gene therapy: results and lessons from recent successes.
Sandeep Rp Kumar, David M Markusic, +2 authors, Roland W Herzog.
Mol Ther Methods Clin Dev, 2016 Jun 04; 3. PMID: 27257611    Free PMC article.
Highly Cited. Review.
Forecasting Cytokine Storms with New Predictive Biomarkers.
Rayne H Rouce, Helen E Heslop.
Cancer Discov, 2016 Jun 05; 6(6). PMID: 27261481    Free PMC article.
Biology and clinical application of CAR T cells for B cell malignancies.
Marco L Davila, Michel Sadelain.
Int J Hematol, 2016 Jun 06; 104(1). PMID: 27262700    Free PMC article.
Review.
Clinical responses with T lymphocytes targeting malignancy-associated κ light chains.
Carlos A Ramos, Barbara Savoldo, +15 authors, Gianpietro Dotti.
J Clin Invest, 2016 Jun 09; 126(7). PMID: 27270177    Free PMC article.
Highly Cited.
CAR T Cell Therapy: A Game Changer in Cancer Treatment.
Hilde Almåsbak, Tanja Aarvak, Mohan C Vemuri.
J Immunol Res, 2016 Jun 15; 2016. PMID: 27298832    Free PMC article.
Review.
Targeting the latent reservoir to achieve functional HIV cure.
Daniele C Cary, B Matija Peterlin.
F1000Res, 2016 Jun 16; 5. PMID: 27303638    Free PMC article.
Review.
Severe Cytokine-Release Syndrome after T Cell-Replete Peripheral Blood Haploidentical Donor Transplantation Is Associated with Poor Survival and Anti-IL-6 Therapy Is Safe and Well Tolerated.
Ramzi Abboud, Jesse Keller, +11 authors, Rizwan Romee.
Biol Blood Marrow Transplant, 2016 Jun 19; 22(10). PMID: 27318038    Free PMC article.
Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform.
Chiara F Magnani, Nice Turazzi, +9 authors, Ettore Biagi.
Oncotarget, 2016 Jun 21; 7(32). PMID: 27323395    Free PMC article.
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.
Avery D Posey, Robert D Schwab, +19 authors, Carl H June.
Immunity, 2016 Jun 23; 44(6). PMID: 27332733    Free PMC article.
Highly Cited.
Clinical manufacturing of CAR T cells: foundation of a promising therapy.
Xiuyan Wang, Isabelle Rivière.
Mol Ther Oncolytics, 2016 Jun 28; 3. PMID: 27347557    Free PMC article.
Highly Cited. Review.
Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps.
Gregory L Beatty, Mark O'Hara.
Pharmacol Ther, 2016 Jul 05; 166. PMID: 27373504    Free PMC article.
Review.
Reduction of Minimal Residual Disease in Pediatric B-lineage Acute Lymphoblastic Leukemia by an Fc-optimized CD19 Antibody.
Ursula Jördis Eva Seidel, Patrick Schlegel, +14 authors, Peter Lang.
Mol Ther, 2016 Jul 07; 24(9). PMID: 27380762    Free PMC article.
Immunotherapeutic strategies targeting natural killer T cell responses in cancer.
Susannah C Shissler, Dominique R Bollino, +3 authors, Tonya J Webb.
Immunogenetics, 2016 Jul 10; 68(8). PMID: 27393665    Free PMC article.
Review.
International AIDS Society global scientific strategy: towards an HIV cure 2016.
Steven G Deeks, Sharon R Lewin, +53 authors, Jerome Zack.
Nat Med, 2016 Jul 12; 22(8). PMID: 27400264    Free PMC article.
Highly Cited.
Feasibility and Safety of RNA-transfected CD20-specific Chimeric Antigen Receptor T Cells in Dogs with Spontaneous B Cell Lymphoma.
M Kazim Panjwani, Jenessa B Smith, +4 authors, Nicola J Mason.
Mol Ther, 2016 Jul 13; 24(9). PMID: 27401141    Free PMC article.
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.
Meenakshi Hegde, Malini Mukherjee, +18 authors, Nabil Ahmed.
J Clin Invest, 2016 Jul 19; 126(8). PMID: 27427982    Free PMC article.
Highly Cited.
Cellular immunotherapy for malignant gliomas.
Yi Lin, Hideho Okada.
Expert Opin Biol Ther, 2016 Jul 20; 16(10). PMID: 27434205    Free PMC article.
Review.
Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target.
Alfredo Perales-Puchalt, Nikolaos Svoronos, +13 authors, Jose R Conejo-Garcia.
Clin Cancer Res, 2016 Jul 21; 23(2). PMID: 27435394    Free PMC article.
Cancer immunotherapy trials: leading a paradigm shift in drug development.
Leisha A Emens, Lisa H Butterfield, +2 authors, Howard L Kaufman.
J Immunother Cancer, 2016 Jul 21; 4. PMID: 27437105    Free PMC article.
In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy.
Ankur Dhanik, Jessica R Kirshner, +4 authors, Wen Zhang.
BMC Bioinformatics, 2016 Jul 22; 17. PMID: 27439771    Free PMC article.
Tumor Regression and Delayed Onset Toxicity Following B7-H4 CAR T Cell Therapy.
Jenessa B Smith, Evripidis Lanitis, +5 authors, Daniel J Powell.
Mol Ther, 2016 Jul 22; 24(11). PMID: 27439899    Free PMC article.
Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level.
De-Gang Song, Qunrui Ye, +3 authors, Daniel J Powell.
J Hematol Oncol, 2016 Jul 22; 9(1). PMID: 27439908    Free PMC article.
Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors.
Eric D Brooks, Jonathan E Schoenhals, +4 authors, James W Welsh.
Cancer J, 2016 Jul 22; 22(4). PMID: 27441745    Free PMC article.
Review.
Driving an improved CAR for cancer immunotherapy.
Xiaopei Huang, Yiping Yang.
J Clin Invest, 2016 Jul 28; 126(8). PMID: 27454296    Free PMC article.
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
Leonid Cherkassky, Aurore Morello, +5 authors, Prasad S Adusumilli.
J Clin Invest, 2016 Jul 28; 126(8). PMID: 27454297    Free PMC article.
Highly Cited.
Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA.
Yun Bai, Shifeng Kan, +5 authors, Hongkui Deng.
Cell Discov, 2015 Jan 01; 1. PMID: 27462436    Free PMC article.
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA.
Nadia Mensali, Fan Ying, +9 authors, Johanna Olweus.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467957    Free PMC article.
Antigen-based immunotherapy for the treatment of acute lymphoblastic leukemia: the emerging role of blinatumomab.
Mark R Litzow.
Immunotargets Ther, 2014 Jan 01; 3. PMID: 27471701    Free PMC article.
Review.
Harnessing immunosurveillance: current developments and future directions in cancer immunotherapy.
Maureen L Drakes, Patrick J Stiff.
Immunotargets Ther, 2014 Jan 01; 3. PMID: 27471706    Free PMC article.
Review.
Improving the safety of T-Cell therapies using an inducible caspase-9 gene.
Xiaoou Zhou, Malcolm K Brenner.
Exp Hematol, 2016 Oct 27; 44(11). PMID: 27473568    Free PMC article.
Review.
Chimeric Antigen Receptor T cells for B Cell Neoplasms: Choose the Right CAR for You.
Marco Ruella, Carl H June.
Curr Hematol Malig Rep, 2016 Aug 01; 11(5). PMID: 27475429
Review.
Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.
Partow Kebriaei, Harjeet Singh, +36 authors, Laurence J N Cooper.
J Clin Invest, 2016 Aug 03; 126(9). PMID: 27482888    Free PMC article.
Highly Cited.
Chimeric antigen receptor (CAR)-directed adoptive immunotherapy: a new era in targeted cancer therapy.
Yamei Chen, Delong Liu.
Stem Cell Investig, 2014 Jan 01; 1. PMID: 27500852    Free PMC article.
Treatment of Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Clinical Advances.
Lynda M Vrooman, Lewis B Silverman.
Curr Hematol Malig Rep, 2016 Aug 10; 11(5). PMID: 27502091
Review.
Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy.
Boris Simovic, Scott R Walsh, Yonghong Wan.
Oncolytic Virother, 2015 Jan 01; 4. PMID: 27512679    Free PMC article.
Review.
Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts.
M Cartellieri, A Feldmann, +7 authors, M P Bachmann.
Blood Cancer J, 2016 Aug 16; 6(8). PMID: 27518241    Free PMC article.
Highly Cited.
The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease.
James C Evans, Meenakshi Malhotra, John F Cryan, Caitriona M O'Driscoll.
Br J Pharmacol, 2016 Aug 16; 173(21). PMID: 27526115    Free PMC article.
Review.
Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity.
Wenpeng Li, Linjie Guo, +8 authors, Andras Heczey.
Hum Gene Ther, 2016 Aug 18; 28(5). PMID: 27530312    Free PMC article.
Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4+ T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppressive Combined Antiretroviral Therapy.
Bingfeng Liu, Fan Zou, +7 authors, Hui Zhang.
J Virol, 2016 Aug 19; 90(21). PMID: 27535056    Free PMC article.
Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors.
Radhika Thokala, Simon Olivares, +9 authors, Laurence J N Cooper.
PLoS One, 2016 Aug 23; 11(8). PMID: 27548616    Free PMC article.
Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas.
Adrienne H Long, Steven L Highfill, +8 authors, Crystal L Mackall.
Cancer Immunol Res, 2016 Aug 24; 4(10). PMID: 27549124    Free PMC article.
Highly Cited.
Engineered T cells: the promise and challenges of cancer immunotherapy.
Andrew D Fesnak, Carl H June, Bruce L Levine.
Nat Rev Cancer, 2016 Aug 24; 16(9). PMID: 27550819    Free PMC article.
Highly Cited. Review.
Automated Enrichment, Transduction, and Expansion of Clinical-Scale CD62L+ T Cells for Manufacturing of Gene Therapy Medicinal Products.
Christoph Priesner, Krasimira Aleksandrova, +10 authors, Ulrike Koehl.
Hum Gene Ther, 2016 Aug 27; 27(10). PMID: 27562135    Free PMC article.
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies.
Marco Ruella, David M Barrett, +18 authors, Saar Gill.
J Clin Invest, 2016 Aug 30; 126(10). PMID: 27571406    Free PMC article.
Highly Cited.
Review: Current clinical applications of chimeric antigen receptor (CAR) modified T cells.
Mark B Geyer, Renier J Brentjens.
Cytotherapy, 2016 Sep 07; 18(11). PMID: 27592405    Free PMC article.
Review.
Selective inhibition of autoimmune exacerbation while preserving the anti-tumor clinical benefit using IL-6 blockade in a patient with advanced melanoma and Crohn's disease: a case report.
Marc Uemura, Van A Trinh, +8 authors, Adi Diab.
J Hematol Oncol, 2016 Sep 07; 9(1). PMID: 27595932    Free PMC article.
High-content molecular profiling of T-cell therapy in oncology.
Ruslan Novosiadly, Michael Kalos.
Mol Ther Oncolytics, 2016 Sep 15; 3. PMID: 27626060    Free PMC article.
Review.
Toxicity and management in CAR T-cell therapy.
Challice L Bonifant, Hollie J Jackson, Renier J Brentjens, Kevin J Curran.
Mol Ther Oncolytics, 2016 Sep 15; 3. PMID: 27626062    Free PMC article.
Highly Cited. Review.
Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.
Julie C Fitzgerald, Scott L Weiss, +10 authors, David T Teachey.
Crit Care Med, 2016 Sep 16; 45(2). PMID: 27632680    Free PMC article.
Highly Cited.
Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse.
Saad S Kenderian, David L Porter, Saar Gill.
Biol Blood Marrow Transplant, 2016 Sep 18; 23(2). PMID: 27638367    Free PMC article.
Review.
Treatment of relapse after allogeneic stem cell transplantation in children and adolescents with ALL: the Frankfurt experience.
A M Willasch, E Salzmann-Manrique, +17 authors, P Bader.
Bone Marrow Transplant, 2016 Sep 20; 52(2). PMID: 27643863
Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination.
Anke Redeker, Ramon Arens.
Front Immunol, 2016 Sep 23; 7. PMID: 27656185    Free PMC article.
Review.
The emerging role of immunotherapy in colorectal cancer.
David Lynch, Adrian Murphy.
Ann Transl Med, 2016 Sep 27; 4(16). PMID: 27668225    Free PMC article.
Review.
Rapid identification of cytokine release syndrome after haploidentical PBSC transplantation and successful therapy with tocilizumab.
C Cho, M A Perales.
Bone Marrow Transplant, 2016 Sep 27; 51(12). PMID: 27668764    Free PMC article.
A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer.
Lorenz Jahn, Renate S Hagedoorn, +7 authors, Mirjam H M Heemskerk.
Oncotarget, 2016 Oct 01; 7(44). PMID: 27689397    Free PMC article.
Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.
Kole T Roybal, Jasper Z Williams, +6 authors, Wendell A Lim.
Cell, 2016 Oct 04; 167(2). PMID: 27693353    Free PMC article.
Highly Cited.
Recent advances and novel treatment paradigms in acute lymphocytic leukemia.
Nikolaos Papadantonakis, Anjali S Advani.
Ther Adv Hematol, 2016 Oct 04; 7(5). PMID: 27695616    Free PMC article.
Review.
A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.
Mark Wunderlich, Courtney Stockman, +5 authors, James C Mulloy.
JCI Insight, 2016 Oct 05; 1(15). PMID: 27699249    Free PMC article.
Recent advances in T-cell engineering for use in immunotherapy.
Preeti Sharma, David M Kranz.
F1000Res, 2016 Oct 06; 5. PMID: 27703664    Free PMC article.
Review.
Novel therapeutic options in Acute Myeloid Leukemia.
Michael Medinger, Claudia Lengerke, Jakob Passweg.
Leuk Res Rep, 2016 Oct 19; 6. PMID: 27752467    Free PMC article.
Review.
Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome.
Linan Wang, Ning Ma, +7 authors, Hiroshi Shiku.
Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757303    Free PMC article.
Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies.
Marco Ruella, Marcela V Maus.
Comput Struct Biotechnol J, 2016 Oct 21; 14. PMID: 27761200    Free PMC article.
Highly Cited. Review.
Investigating CD99 Expression in Leukemia Propagating Cells in Childhood T Cell Acute Lymphoblastic Leukemia.
Charlotte V Cox, Paraskevi Diamanti, John P Moppett, Allison Blair.
PLoS One, 2016 Oct 21; 11(10). PMID: 27764235    Free PMC article.
Generation of CD20-specific TCRs for TCR gene therapy of CD20low B-cell malignancies insusceptible to CD20-targeting antibodies.
Lorenz Jahn, Dirk M van der Steen, +7 authors, Mirjam H M Heemskerk.
Oncotarget, 2016 Oct 25; 7(47). PMID: 27776339    Free PMC article.
Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition.
Jiangtao Ren, Xiaojun Liu, +3 authors, Yangbing Zhao.
Clin Cancer Res, 2016 Nov 07; 23(9). PMID: 27815355    Free PMC article.
Highly Cited.
Intraperitoneal immunotherapy: historical perspectives and modern therapy.
W F Morano, A Aggarwal, +3 authors, W B Bowne.
Cancer Gene Ther, 2016 Nov 12; 23(11). PMID: 27834358
Review.
Gene Targeting Meets Cell-Based Therapy: Raising the Tail, or Merely a Whimper?
Alexandria P Cogdill, Peter A Prieto, Alexandre Reuben, Jennifer A Wargo.
Clin Cancer Res, 2016 Nov 12; 23(2). PMID: 27836861    Free PMC article.
Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice.
Marie-Louise Sentman, Joana M Murad, +6 authors, Charles L Sentman.
J Immunol, 2016 Nov 17; 197(12). PMID: 27849169    Free PMC article.
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity.
Michael S Magee, Crystal L Kraft, +5 authors, Adam E Snook.
Oncoimmunology, 2016 Nov 18; 5(10). PMID: 27853651    Free PMC article.
Longitudinal PET imaging demonstrates biphasic CAR T cell responses in survivors.
Yogindra Vedvyas, Enda Shevlin, +13 authors, Moonsoo M Jin.
JCI Insight, 2016 Nov 25; 1(19). PMID: 27882353    Free PMC article.
Promising Novel Agents for Aggressive B-Cell Lymphoma.
Anas Younes.
Hematol Oncol Clin North Am, 2016 Nov 28; 30(6). PMID: 27888877    Free PMC article.
Review.
Chimeric antigen receptor T cell therapy in AML: How close are we?
Saar Gill.
Best Pract Res Clin Haematol, 2016 Nov 29; 29(4). PMID: 27890255    Free PMC article.
Review.
Recent Developments in Cellular Immunotherapy for HSCT-Associated Complications.
Monica Reis, Justyna Ogonek, +7 authors, Anne Richter.
Front Immunol, 2016 Nov 30; 7. PMID: 27895644    Free PMC article.
Review.
Combining Cell and Gene Therapy in an Effort to Eradicate HIV.
Thor A Wagner.
AIDS Patient Care STDS, 2016 Dec 03; 30(12). PMID: 27905840    Free PMC article.
Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia.
Noelle V Frey, David L Porter.
Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913530    Free PMC article.
Review.
A New Agent in the Strategy to Cure AIDS.
John A Zaia.
Mol Ther, 2016 Dec 06; 24(11). PMID: 27916996    Free PMC article.
Role of immune cells in pancreatic cancer from bench to clinical application: An updated review.
Jae Hyuck Chang, Yongjian Jiang, Venu G Pillarisetty.
Medicine (Baltimore), 2016 Dec 09; 95(49). PMID: 27930550    Free PMC article.
Review.
CD19-Targeted CAR T cells as novel cancer immunotherapy for relapsed or refractory B-cell acute lymphoblastic leukemia.
Marco L Davila, Renier J Brentjens.
Clin Adv Hematol Oncol, 2016 Dec 09; 14(10). PMID: 27930631    Free PMC article.
Review.
Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.
Ju Huang, Yuanfeng Liu, +7 authors, Jeffrey A Medin.
Mol Ther Methods Clin Dev, 2016 Dec 10; 3. PMID: 27933304    Free PMC article.
Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials.
Jonathan H Esensten, Jeffrey A Bluestone, Wendell A Lim.
Annu Rev Pathol, 2016 Dec 14; 12. PMID: 27959633    Free PMC article.
Review.
Genome and Epigenome Editing in Mechanistic Studies of Human Aging and Aging-Related Disease.
Cia-Hin Lau, Yousin Suh.
Gerontology, 2016 Dec 16; 63(2). PMID: 27974723    Free PMC article.
Review.
Immuno-Oncology: The Third Paradigm in Early Drug Development.
Juan Martin-Liberal, Cinta Hierro, Maria Ochoa de Olza, Jordi Rodon.
Target Oncol, 2016 Dec 21; 12(2). PMID: 27995439
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia.
Michael Boyiadzis, Michael R Bishop, +45 authors, Madhav V Dhodapkar.
J Immunother Cancer, 2016 Dec 27; 4. PMID: 28018601    Free PMC article.
Driving gene-engineered T cell immunotherapy of cancer.
Laura A Johnson, Carl H June.
Cell Res, 2016 Dec 28; 27(1). PMID: 28025979    Free PMC article.
Highly Cited. Review.
Immune targets and neoantigens for cancer immunotherapy and precision medicine.
Rong-Fu Wang, Helen Y Wang.
Cell Res, 2016 Dec 28; 27(1). PMID: 28025978    Free PMC article.
Highly Cited. Review.
Redirecting T cells to eradicate B-cell acute lymphoblastic leukemia: bispecific T-cell engagers and chimeric antigen receptors.
I Aldoss, R C Bargou, +3 authors, S J Forman.
Leukemia, 2016 Dec 29; 31(4). PMID: 28028314
Review.
A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy.
Erhao Zhang, Hanmei Xu.
J Hematol Oncol, 2017 Jan 05; 10(1). PMID: 28049484    Free PMC article.
Highly Cited. Review.
Chimaeric antigen receptor T-cell therapy for tumour immunotherapy.
Huan-Huan Sha, Dan-Dan Wang, +4 authors, Ji-Feng Feng.
Biosci Rep, 2017 Jan 06; 37(1). PMID: 28053197    Free PMC article.
Review.
Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma.
Kai-Chao Feng, Ye-Lei Guo, +6 authors, Wei-Dong Han.
J Hematol Oncol, 2017 Jan 07; 10(1). PMID: 28057014    Free PMC article.
Highly Cited.
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.
Arnab Ghosh, Melody Smith, +23 authors, Marcel R M van den Brink.
Nat Med, 2017 Jan 10; 23(2). PMID: 28067900    Free PMC article.
Highly Cited.
Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors.
Gang Xin, David M Schauder, +4 authors, Weiguo Cui.
Proc Natl Acad Sci U S A, 2017 Jan 11; 114(4). PMID: 28069963    Free PMC article.
T Cell Maturation Stage Prior to and During GMP Processing Informs on CAR T Cell Expansion in Patients.
Yarne Klaver, Sabine C L van Steenbergen, +2 authors, Cor H J Lamers.
Front Immunol, 2017 Jan 14; 7. PMID: 28082983    Free PMC article.
All-trans retinoic acid enhances cytotoxic effect of T cells with an anti-CD38 chimeric antigen receptor in acute myeloid leukemia.
Tetsumi Yoshida, Keichiro Mihara, +7 authors, Tatsuo Ichinohe.
Clin Transl Immunology, 2017 Jan 17; 5(12). PMID: 28090317    Free PMC article.
Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma.
Khun Visith Keu, Timothy H Witney, +14 authors, Sanjiv S Gambhir.
Sci Transl Med, 2017 Jan 20; 9(373). PMID: 28100832    Free PMC article.
Highly Cited.
An oxygen sensitive self-decision making engineered CAR T-cell.
Alexandre Juillerat, Alan Marechal, +5 authors, Laurent Poirot.
Sci Rep, 2017 Jan 21; 7. PMID: 28106050    Free PMC article.
Chimeric Antigen Receptor (CAR) T Cells: Lessons Learned from Targeting of CD19 in B-Cell Malignancies.
Kevin A Hay, Cameron J Turtle.
Drugs, 2017 Jan 23; 77(3). PMID: 28110394    Free PMC article.
Review.
Targeted breast cancer therapy by harnessing the inherent blood group antigen immune system.
Wei Han, Wei Li, +7 authors, Jiuwei Cui.
Oncotarget, 2017 Jan 26; 8(9). PMID: 28122343    Free PMC article.
T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy.
Jon Amund Kyte, Gustav Gaudernack, +7 authors, Martin Pule.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123886    Free PMC article.
CAR-T cell therapy in gastrointestinal tumors and hepatic carcinoma: From bench to bedside.
Qi Zhang, Zimu Zhang, +3 authors, Rongxin Zhang.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123893    Free PMC article.
Review.
Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer.
Somala Mohammed, Sujita Sukumaran, +7 authors, Juan F Vera.
Mol Ther, 2017 Jan 28; 25(1). PMID: 28129119    Free PMC article.
Highly Cited.
Masked Chimeric Antigen Receptor for Tumor-Specific Activation.
Xiaolu Han, Paul D Bryson, +5 authors, Pin Wang.
Mol Ther, 2017 Jan 28; 25(1). PMID: 28129121    Free PMC article.
CARs Move To the Fast Lane.
Marco L Davila, Eirini P Papapetrou.
Mol Ther, 2014 Mar 01; 22(3). PMID: 28141992    Free PMC article.
Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies.
Jun Liu, Jiang F Zhong, Xi Zhang, Cheng Zhang.
J Hematol Oncol, 2017 Feb 02; 10(1). PMID: 28143567    Free PMC article.
Review.
The Flipside of the Power of Engineered T Cells: Observed and Potential Toxicities of Genetically Modified T Cells as Therapy.
Felipe Bedoya, Matthew J Frigault, Marcela V Maus.
Mol Ther, 2017 Feb 06; 25(2). PMID: 28153085    Free PMC article.
Review.
Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy.
Julien Fleurence, Sophie Fougeray, +5 authors, Stéphane Birklé.
J Immunol Res, 2017 Feb 06; 2017. PMID: 28154831    Free PMC article.
Review.
Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.
Allison A Aka, Jeff A Rappaport, +3 authors, Scott A Waldman.
Expert Rev Clin Pharmacol, 2017 Feb 07; 10(5). PMID: 28162021    Free PMC article.
Review.
Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases.
Sugiko Watanabe, Shimpei Kawamoto, Naoko Ohtani, Eiji Hara.
Cancer Sci, 2017 Feb 07; 108(4). PMID: 28165648    Free PMC article.
Highly Cited. Review.
Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening.
Matthias Schröder, Simone Loos, +5 authors, Lee Kim Swee.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197378    Free PMC article.
A versatile system for rapid multiplex genome-edited CAR T cell generation.
Jiangtao Ren, Xuhua Zhang, +4 authors, Yangbing Zhao.
Oncotarget, 2017 Feb 16; 8(10). PMID: 28199983    Free PMC article.
Highly Cited.
Fully human CD19-specific chimeric antigen receptors for T-cell therapy.
D Sommermeyer, T Hill, +4 authors, S R Riddell.
Leukemia, 2017 Feb 17; 31(10). PMID: 28202953    Free PMC article.
Highly Cited.
Immune-Mediated Therapies for Liver Cancer.
Rajagopal N Aravalli, Clifford J Steer.
Genes (Basel), 2017 Feb 22; 8(2). PMID: 28218682    Free PMC article.
Review.
Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma.
Alan T Yeo, Alain Charest.
J Cell Biochem, 2017 Feb 24; 118(9). PMID: 28230277    Free PMC article.
Review.
CARs in the Lead Against Multiple Myeloma.
Maria Ormhøj, Felipe Bedoya, Matthew J Frigault, Marcela V Maus.
Curr Hematol Malig Rep, 2017 Feb 25; 12(2). PMID: 28233151    Free PMC article.
Review.
Targeting neoantigens to augment antitumour immunity.
Mark Yarchoan, Burles A Johnson, +2 authors, Elizabeth M Jaffee.
Nat Rev Cancer, 2017 Feb 25; 17(4). PMID: 28233802    Free PMC article.
Highly Cited. Review.
Autologous lymphapheresis for the production of chimeric antigen receptor T cells.
Elizabeth S Allen, David F Stroncek, +6 authors, Cathy Conry-Cantilena.
Transfusion, 2017 Feb 27; 57(5). PMID: 28236305    Free PMC article.
Combination immunotherapy: a road map.
Patrick A Ott, F Stephen Hodi, +2 authors, Jedd D Wolchok.
J Immunother Cancer, 2017 Feb 28; 5. PMID: 28239469    Free PMC article.
Highly Cited. Review.
T cell immunoengineering with advanced biomaterials.
Derfogail Delcassian, Susanne Sattler, Iain E Dunlop.
Integr Biol (Camb), 2017 Mar 03; 9(3). PMID: 28252135    Free PMC article.
Review.
The role of radiation in treating glioblastoma: here to stay.
Christopher D Corso, Ranjit S Bindra, Minesh P Mehta.
J Neurooncol, 2017 Mar 09; 134(3). PMID: 28271281
Review.
The basics of CAR T design and challenges in immunotherapy of solid tumors - Ovarian cancer as a model.
Xuequn Xu, Jin Qiu, Yi Sun.
Hum Vaccin Immunother, 2017 Mar 09; 13(7). PMID: 28272967    Free PMC article.
Review.
Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis.
Daniel J Neitzke, Jacob S Bowers, +7 authors, Mark P Rubinstein.
Cancer Immunol Immunother, 2017 Mar 11; 66(6). PMID: 28280853    Free PMC article.
Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment.
Yelei Guo, Kaichao Feng, Yao Wang, Weidong Han.
Protein Cell, 2017 Mar 16; 9(6). PMID: 28290053    Free PMC article.
Review.
Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells.
David F Stroncek, Daniel W Lee, +7 authors, Crystal L Mackall.
J Transl Med, 2017 Mar 17; 15(1). PMID: 28298232    Free PMC article.
Clinical development of anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma.
Shinichi Makita, Kiyoshi Yoshimura, Kensei Tobinai.
Cancer Sci, 2017 Mar 17; 108(6). PMID: 28301076    Free PMC article.
Review.
[Immunotherapy of cancer with checkpoint inhibitors : Not only in malignant melanoma].
A Neubauer.
Internist (Berl), 2017 Mar 18; 58(4). PMID: 28303311
Review.
Development of CAR T cells designed to improve antitumor efficacy and safety.
Janneke E Jaspers, Renier J Brentjens.
Pharmacol Ther, 2017 Mar 28; 178. PMID: 28342824    Free PMC article.
Review.
Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells.
Malika Hale, Baeckseung Lee, +9 authors, David J Rawlings.
Mol Ther Methods Clin Dev, 2017 Mar 28; 4. PMID: 28345004    Free PMC article.
Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade.
Inna Serganova, Ekaterina Moroz, +6 authors, Ronald Blasberg.
Mol Ther Oncolytics, 2017 Mar 28; 4. PMID: 28345023    Free PMC article.
CAR T-cell therapy for pancreatic cancer.
Carl J DeSelm, Zachary E Tano, Anna M Varghese, Prasad S Adusumilli.
J Surg Oncol, 2017 Mar 28; 116(1). PMID: 28346697    Free PMC article.
Review.
Cancer Immunotherapy: Whence and Whither.
Peter J Stambrook, John Maher, Farzin Farzaneh.
Mol Cancer Res, 2017 Mar 31; 15(6). PMID: 28356330    Free PMC article.
Review.
Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers.
Chengcheng Zhang, Zhe Wang, +20 authors, Cheng Qian.
Mol Ther, 2017 Apr 04; 25(5). PMID: 28366766    Free PMC article.
Highly Cited.
Cardiovascular Complications Associated With Novel Cancer Immunotherapies.
Varun Jain, Jaspreet Bahia, Mahsa Mohebtash, Ana Barac.
Curr Treat Options Cardiovasc Med, 2017 Apr 13; 19(5). PMID: 28401456
Review.
Antigen Discovery and Therapeutic Targeting in Hematologic Malignancies.
David A Braun, Catherine J Wu.
Cancer J, 2017 Apr 15; 23(2). PMID: 28410299    Free PMC article.
Review.
Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia.
Guoqing Wei, Lijuan Ding, +2 authors, He Huang.
Exp Hematol Oncol, 2017 Apr 18; 6. PMID: 28413717    Free PMC article.
Highly Cited. Review.
In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance.
Ryan M Pearson, Liam M Casey, +2 authors, Lonnie D Shea.
Adv Drug Deliv Rev, 2017 Apr 18; 114. PMID: 28414079    Free PMC article.
Review.
CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond.
ZeNan L Chang, Yvonne Y Chen.
Trends Mol Med, 2017 Apr 19; 23(5). PMID: 28416139    Free PMC article.
Review.
In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers.
Tyrel T Smith, Sirkka B Stephan, +7 authors, Matthias T Stephan.
Nat Nanotechnol, 2017 Apr 19; 12(8). PMID: 28416815    Free PMC article.
Highly Cited.
Regulatory T cells: tolerance induction in solid organ transplantation.
T Vaikunthanathan, N Safinia, +2 authors, G Lombardi.
Clin Exp Immunol, 2017 Apr 20; 189(2). PMID: 28422316    Free PMC article.
Review.
Immunotherapy of hepatocellular carcinoma using chimeric antigen receptors and bispecific antibodies.
Sayed Shahabuddin Hoseini, Nai-Kong V Cheung.
Cancer Lett, 2017 Apr 22; 399. PMID: 28428075    Free PMC article.
Review.
The Why, what, and How of the New FACT standards for immune effector cells.
Marcela V Maus, Sarah Nikiforow.
J Immunother Cancer, 2017 Apr 22; 5. PMID: 28428885    Free PMC article.
Increasing the safety and efficacy of chimeric antigen receptor T cell therapy.
Hua Li, Yangbing Zhao.
Protein Cell, 2017 Apr 24; 8(8). PMID: 28434147    Free PMC article.
Review.
Immunotherapy in hematologic malignancies: past, present, and future.
Annie Im, Steven Z Pavletic.
J Hematol Oncol, 2017 Apr 25; 10(1). PMID: 28434396    Free PMC article.
Review.
Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors.
Tyrel T Smith, Howell F Moffett, +7 authors, Matthias T Stephan.
J Clin Invest, 2017 Apr 25; 127(6). PMID: 28436934    Free PMC article.
Highly Cited.
CD19 Isoforms Enabling Resistance to CART-19 Immunotherapy Are Expressed in B-ALL Patients at Initial Diagnosis.
Jeannette Fischer, Claudia Paret, +12 authors, Jörg Faber.
J Immunother, 2017 Apr 26; 40(5). PMID: 28441264    Free PMC article.
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.
Kole T Roybal, Wendell A Lim.
Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446063    Free PMC article.
Review.
Is Next-Generation Sequencing the way to go for Residual Disease Monitoring in Acute Lymphoblastic Leukemia?
Michaela Kotrova, Jan Trka, Michael Kneba, Monika Brüggemann.
Mol Diagn Ther, 2017 Apr 30; 21(5). PMID: 28452038
Review.
Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective.
Isabelle Rivière, Michel Sadelain.
Mol Ther, 2017 May 01; 25(5). PMID: 28456379    Free PMC article.
Review.
Engineering Chimeric Antigen Receptors.
S V Kulemzin, V V Kuznetsova, +2 authors, A A Gorchakov.
Acta Naturae, 2017 May 04; 9(1). PMID: 28461969    Free PMC article.
Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment.
Zhenguang Wang, Yelei Guo, Weidong Han.
Protein Cell, 2017 May 04; 8(12). PMID: 28466386    Free PMC article.
Review.
Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia.
L Chen, H Mao, +4 authors, J Yu.
Leukemia, 2017 May 13; 31(8). PMID: 28496177    Free PMC article.
Current status of chimeric antigen receptor engineered T cell-based and immune checkpoint blockade-based cancer immunotherapies.
Upendra P Hegde, Bijay Mukherji.
Cancer Immunol Immunother, 2017 May 13; 66(9). PMID: 28497159    Free PMC article.
Review.
Immunotherapy is different: Implications for vaccine clinical trial design.
Richard Simon.
Hum Vaccin Immunother, 2017 May 13; 13(9). PMID: 28498733    Free PMC article.
A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization.
Esther Drent, Maria Themeli, +9 authors, Tuna Mutis.
Mol Ther, 2017 May 17; 25(8). PMID: 28506593    Free PMC article.
Highly Cited.
A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines.
Dina Schneider, Ying Xiong, +6 authors, Rimas J Orentas.
J Immunother Cancer, 2017 May 19; 5. PMID: 28515942    Free PMC article.
Highly Cited.
Preclinical rationale for combining radiation therapy and immunotherapy beyond checkpoint inhibitors (i.e., CART).
James P Flynn, Mark H O'Hara, Saumil J Gandhi.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529898    Free PMC article.
Review.
Genetic Modification of T Cells.
Richard A Morgan, Benjamin Boyerinas.
Biomedicines, 2017 May 26; 4(2). PMID: 28536376    Free PMC article.
Review.
Prospect of Immunotherapy for Glioblastoma: Tumor Vaccine, Immune Checkpoint Inhibitors and Combination Therapy.
Eiichi Ishikawa, Tetsuya Yamamoto, Akira Matsumura.
Neurol Med Chir (Tokyo), 2017 May 26; 57(7). PMID: 28539528    Free PMC article.
Review.
Oncolytic Adenoviruses in Cancer Treatment.
Ramon Alemany.
Biomedicines, 2014 Feb 21; 2(1). PMID: 28548059    Free PMC article.
Review.
Lentivirus-Induced Dendritic Cells (iDC) for Immune-Regenerative Therapies in Cancer and Stem Cell Transplantation.
Renata Stripecke.
Biomedicines, 2014 Aug 21; 2(3). PMID: 28548069    Free PMC article.
Review.
Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells.
Michael Schmueck-Henneresse, Bilal Omer, +9 authors, Cliona M Rooney.
J Immunol, 2017 May 28; 199(1). PMID: 28550199    Free PMC article.
New targeted therapies for relapsed pediatric acute lymphoblastic leukemia.
Joanna Pierro, Laura E Hogan, Teena Bhatla, William L Carroll.
Expert Rev Anticancer Ther, 2017 Jun 27; 17(8). PMID: 28649891    Free PMC article.
Review.
Hemophilia A inhibitor treatment: the promise of engineered T-cell therapy.
Kalpana Parvathaneni, Maha Abdeladhim, Kathleen P Pratt, David W Scott.
Transl Res, 2017 Jun 27; 187. PMID: 28651073    Free PMC article.
Review.
Adult cancer-related hemophagocytic lymphohistiocytosis - a challenging diagnosis: a case report.
Michael A Hust, Boris R A Blechacz, +2 authors, Cristhiam M Rojas-Hernandez.
J Med Case Rep, 2017 Jun 28; 11(1). PMID: 28651636    Free PMC article.
CSPG4: a prototype oncoantigen for translational immunotherapy studies.
Valeria Rolih, Giuseppina Barutello, +5 authors, Federica Riccardo.
J Transl Med, 2017 Jul 03; 15(1). PMID: 28668095    Free PMC article.
Review.
Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase.
Alec J Walker, Robbie G Majzner, +8 authors, Crystal L Mackall.
Mol Ther, 2017 Jul 06; 25(9). PMID: 28676342    Free PMC article.
Highly Cited.
Treatment of Acute Myeloid Leukemia with T Cells Expressing Chimeric Antigen Receptors Directed to C-type Lectin-like Molecule 1.
Haruko Tashiro, Tim Sauer, +8 authors, Malcolm K Brenner.
Mol Ther, 2017 Jul 06; 25(9). PMID: 28676343    Free PMC article.
5T4-specific chimeric antigen receptor modification promotes the immune efficacy of cytokine-induced killer cells against nasopharyngeal carcinoma stem cell-like cells.
Xueyang Guo, Hang Zheng, +3 authors, Kaitai Yao.
Sci Rep, 2017 Jul 09; 7(1). PMID: 28687750    Free PMC article.
A Novel Target Antigen for the Treatment of Acute Myeloid Leukemia by CAR T Cells.
Paul A Beavis, Kevin Sek, Phillip K Darcy.
Mol Ther, 2017 Jul 18; 25(9). PMID: 28712546    Free PMC article.
Immunotherapy for malignant pleural mesothelioma: current status and future directions.
Jordan Dozier, Hua Zheng, Prasad S Adusumilli.
Transl Lung Cancer Res, 2017 Jul 18; 6(3). PMID: 28713676    Free PMC article.
Review.
Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity.
E Liu, Y Tong, +20 authors, K Rezvani.
Leukemia, 2017 Jul 21; 32(2). PMID: 28725044    Free PMC article.
Highly Cited.
Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma.
Nan Li, Haiying Fu, +2 authors, Mitchell Ho.
Proc Natl Acad Sci U S A, 2017 Jul 26; 114(32). PMID: 28739923    Free PMC article.
Reconstructing the immune system with lentiviral vectors.
Henning Olbrich, Constanze Slabik, Renata Stripecke.
Virus Genes, 2017 Jul 27; 53(5). PMID: 28744797    Free PMC article.
Review.
A Fusion Receptor as a Safety Switch, Detection, and Purification Biomarker for Adoptive Transferred T Cells.
Xiuqi Wu, Bizhi Shi, +8 authors, Zonghai Li.
Mol Ther, 2017 Aug 02; 25(10). PMID: 28757080    Free PMC article.
Maternal Immunization: New Perspectives on Its Application Against Non-Infectious Related Diseases in Newborns.
Federica Riccardo, Aline Réal, +3 authors, Giuseppina Barutello.
Vaccines (Basel), 2017 Aug 02; 5(3). PMID: 28763018    Free PMC article.
Review.
Adnectin-Based Design of Chimeric Antigen Receptor for T Cell Engineering.
Xiaolu Han, Gunce E Cinay, +3 authors, Pin Wang.
Mol Ther, 2017 Aug 09; 25(11). PMID: 28784559    Free PMC article.
Opportunities and challenges in the immunological therapy of pediatric malignancy: a concise snapshot.
Francesco Ceppi, Maja Beck-Popovic, Jean-Pierre Bourquin, Raffaele Renella.
Eur J Pediatr, 2017 Aug 15; 176(9). PMID: 28803259
Review.
Combination of celecoxib (Celebrex®) and CD19 CAR-redirected CTL immunotherapy for the treatment of B-cell non-Hodgkin's lymphomas.
Tam Nm Dinh, Alexandra S Onea, Ali R Jazirehi.
Am J Clin Exp Immunol, 2017 Aug 15; 6(3). PMID: 28804691    Free PMC article.
Review.
An ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors.
Satyen Harish Gohil, Solange Rosa Paredes-Moscosso, +7 authors, Marco Della Peruta.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811962    Free PMC article.
RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma.
Dennis C Harrer, Bianca Simon, +7 authors, Niels Schaft.
BMC Cancer, 2017 Aug 19; 17(1). PMID: 28818060    Free PMC article.
Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia.
Guoqing Wei, Jiasheng Wang, He Huang, Yanmin Zhao.
J Hematol Oncol, 2017 Aug 20; 10(1). PMID: 28821272    Free PMC article.
Review.
CD28 and 41BB Costimulation Enhances the Effector Function of CD19-Specific Engager T Cells.
Mireya Paulina Velasquez, Arpad Szoor, +5 authors, Stephen Gottschalk.
Cancer Immunol Res, 2017 Aug 20; 5(10). PMID: 28821531    Free PMC article.
Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models.
William K Decker, Rodrigo F da Silva, +5 authors, Silke Paust.
Front Immunol, 2017 Aug 22; 8. PMID: 28824608    Free PMC article.
Highly Cited. Review.
Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells.
Y Lai, J Weng, +14 authors, P Li.
Leukemia, 2017 Aug 26; 32(3). PMID: 28841215
Natural Killer Cells: Angels and Devils for Immunotherapy.
Beatriz Martín-Antonio, Guillermo Suñe, +2 authors, Alvaro Urbano-Ispizua.
Int J Mol Sci, 2017 Aug 30; 18(9). PMID: 28850071    Free PMC article.
Review.
Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia.
Mingxue Fan, Minghao Li, +5 authors, Lei Yu.
J Hematol Oncol, 2017 Aug 31; 10(1). PMID: 28851445    Free PMC article.
Highly Cited. Review.
Assessment of selected media supplements to improve F/HN lentiviral vector production yields.
Jean-François Gélinas, Lee A Davies, Deborah R Gill, Stephen C Hyde.
Sci Rep, 2017 Sep 02; 7(1). PMID: 28860488    Free PMC article.
Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity.
Valsamo Anagnostou, Mark Yarchoan, +6 authors, Patrick M Forde.
Clin Cancer Res, 2017 Sep 03; 23(17). PMID: 28864724    Free PMC article.
Novel GP64 envelope variants for improved delivery to human airway epithelial cells.
P L Sinn, B-Y Hwang, +6 authors, P B McCray.
Gene Ther, 2017 Sep 08; 24(10). PMID: 28880020    Free PMC article.
Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors.
Toni A Baeumler, Ahmed Ashour Ahmed, Tudor A Fulga.
Cell Rep, 2017 Sep 14; 20(11). PMID: 28903044    Free PMC article.
Therapeutic potential of SGN-CD19B, a PBD-based anti-CD19 drug conjugate, for treatment of B-cell malignancies.
Maureen C Ryan, Maria Corinna Palanca-Wessels, +6 authors, Dennis Benjamin.
Blood, 2017 Sep 15; 130(18). PMID: 28903943    Free PMC article.
Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy.
Kevin A Hay, Laïla-Aïcha Hanafi, +12 authors, Cameron J Turtle.
Blood, 2017 Sep 20; 130(21). PMID: 28924019    Free PMC article.
Highly Cited.
Chimeric antigen receptor T-cell therapy - assessment and management of toxicities.
Sattva S Neelapu, Sudhakar Tummala, +16 authors, Elizabeth J Shpall.
Nat Rev Clin Oncol, 2017 Sep 20; 15(1). PMID: 28925994    Free PMC article.
Highly Cited. Review.
Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future.
Sarene Koh, Anthony Tanoto Tan, Lietao Li, Antonio Bertoletti.
Diseases, 2016 Feb 15; 4(1). PMID: 28933390    Free PMC article.
Review.
Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia.
Karen Thudium Mueller, Shannon L Maude, +11 authors, Simon F Lacey.
Blood, 2017 Sep 25; 130(21). PMID: 28935694    Free PMC article.
Highly Cited.
The role of novel immunotherapies in non-Hodgkin lymphoma.
Allyson Pishko, Sunita D Nasta.
Transl Cancer Res, 2017 Sep 29; 6(1). PMID: 28955654    Free PMC article.
Perspective on the dynamics of cancer.
Youcef Derbal.
Theor Biol Med Model, 2017 Oct 04; 14(1). PMID: 28969664    Free PMC article.
Review.
Anti-CD 19 and anti-CD 20 CAR-modified T cells for B-cell malignancies: a systematic review and meta-analysis.
Irbaz Bin Riaz, Umar Zahid, +11 authors, Faiz Anwer.
Immunotherapy, 2017 Oct 04; 9(12). PMID: 28971751    Free PMC article.
Systematic Review.
Resources for Interpreting Variants in Precision Genomic Oncology Applications.
Hsinyi Tsang, KanakaDurga Addepalli, Sean R Davis.
Front Oncol, 2017 Oct 05; 7. PMID: 28975082    Free PMC article.
Review.
Generation and characterization of ErbB2-CAR-engineered cytokine-induced killer cells for the treatment of high-risk soft tissue sarcoma in children.
Michael Merker, Verena Pfirrmann, +5 authors, Eva Rettinger.
Oncotarget, 2017 Oct 17; 8(39). PMID: 29029499    Free PMC article.
Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR.
Miguel-Angel Perales, Partow Kebriaei, Leslie S Kean, Michel Sadelain.
Biol Blood Marrow Transplant, 2017 Oct 17; 24(1). PMID: 29032264    Free PMC article.
Review.
Coccidioidomycosis, immunoglobulin deficiency: safety challenges with CAR T cells therapy for relapsed lymphoma.
Umar Zahid, Al-Aman Shaukat, Nida Hassan, Faiz Anwer.
Immunotherapy, 2017 Oct 17; 9(13). PMID: 29032736    Free PMC article.
Specifically differentiated T cell subset promotes tumor immunity over fatal immunity.
Abdulraouf Ramadan, Brad Griesenauer, +5 authors, Sophie Paczesny.
J Exp Med, 2017 Oct 19; 214(12). PMID: 29038366    Free PMC article.
Advances in the treatment of newly diagnosed primary central nervous system lymphomas.
Liren Qian, Ciprian Tomuleasa, +4 authors, Delia Dima.
Blood Res, 2017 Oct 19; 52(3). PMID: 29043230    Free PMC article.
Review.
Development of T-cell immunotherapy for hematopoietic stem cell transplantation recipients at risk of leukemia relapse.
Robson G Dossa, Tanya Cunningham, +4 authors, Marie Bleakley.
Blood, 2017 Oct 21; 131(1). PMID: 29051183    Free PMC article.
Clinical trials of CAR-T cells in China.
Bingshan Liu, Yongping Song, Delong Liu.
J Hematol Oncol, 2017 Oct 24; 10(1). PMID: 29058636    Free PMC article.
Highly Cited.
Immunotherapy for Pediatric Brain Tumors.
Elias J Sayour, Duane A Mitchell.
Brain Sci, 2017 Oct 27; 7(10). PMID: 29065490    Free PMC article.
Review.
Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity.
Spencer Park, Enda Shevlin, +5 authors, Moonsoo M Jin.
Sci Rep, 2017 Nov 01; 7(1). PMID: 29085043    Free PMC article.
Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma.
Christine E Brown, Brenda Aguilar, +12 authors, Stephen J Forman.
Mol Ther, 2017 Nov 07; 26(1). PMID: 29103912    Free PMC article.
The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy.
Naoki Hosen, Yukiko Matsunaga, +31 authors, Atsushi Kumanogoh.
Nat Med, 2017 Nov 07; 23(12). PMID: 29106400
Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer.
Julia Tchou, Yangbing Zhao, +23 authors, Carl H June.
Cancer Immunol Res, 2017 Nov 08; 5(12). PMID: 29109077    Free PMC article.
Highly Cited.
The Anti-Tumor Effects of M1 Macrophage-Loaded Poly (ethylene glycol) and Gelatin-Based Hydrogels on Hepatocellular Carcinoma.
Alberto Daniel Guerra, Oscar W H Yeung, +2 authors, Kwan Man.
Theranostics, 2017 Nov 08; 7(15). PMID: 29109772    Free PMC article.
Characterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model.
Elham Pishali Bejestani, Marc Cartellieri, +14 authors, Malte von Bonin.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123951    Free PMC article.
Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types.
Caroline Lonez, Bikash Verma, +13 authors, Frédéric F Lehmann.
BMJ Open, 2017 Nov 15; 7(11). PMID: 29133316    Free PMC article.
Redirecting T cells to glypican-3 with 28.41BB.ζ and 28.ζ-41BBL CARs for hepatocellular carcinoma treatment.
Haili Ma, Siye Chen, +12 authors, Xiaowen He.
Protein Cell, 2017 Nov 17; 9(7). PMID: 29143211    Free PMC article.
Effective control of acute myeloid leukaemia and acute lymphoblastic leukaemia progression by telomerase specific adoptive T-cell therapy.
Sara Sandri, Francesco De Sanctis, +15 authors, Stefano Ugel.
Oncotarget, 2017 Nov 21; 8(50). PMID: 29152058    Free PMC article.
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.
Terry J Fry, Nirali N Shah, +21 authors, Crystal L Mackall.
Nat Med, 2017 Nov 21; 24(1). PMID: 29155426    Free PMC article.
Highly Cited.
Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response.
Qiong Xue, Emily Bettini, +11 authors, Jing Zhou.
J Immunother Cancer, 2017 Nov 22; 5(1). PMID: 29157295    Free PMC article.
Young donor white blood cell immunotherapy induces extensive tumor necrosis in advanced-stage solid tumors.
Dipnarine Maharaj, Pedro G Vianna, +5 authors, Zheng Cui.
Heliyon, 2017 Nov 22; 3(10). PMID: 29159318    Free PMC article.
Restoring Natural Killer Cell Immunity against Multiple Myeloma in the Era of New Drugs.
Gianfranco Pittari, Luca Vago, +4 authors, Benedetto Bruno.
Front Immunol, 2017 Nov 23; 8. PMID: 29163516    Free PMC article.
Review.
Preclinical Optimization of a CD20-specific Chimeric Antigen Receptor Vector and Culture Conditions.
Sang Yun Lee, Philip Olsen, +9 authors, Brian G Till.
J Immunother, 2017 Nov 28; 41(1). PMID: 29176334    Free PMC article.
From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance.
David W Scott.
Front Immunol, 2017 Nov 29; 8. PMID: 29181011    Free PMC article.
Review.
Incorporation of nonchemotherapeutic agents in pediatric acute lymphoblastic leukemia.
Lewis B Silverman.
Hematology Am Soc Hematol Educ Program, 2017 Dec 10; 2017(1). PMID: 29222264    Free PMC article.
Review.
Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas.
Stephen J Schuster, Jakub Svoboda, +13 authors, Carl H June.
N Engl J Med, 2017 Dec 12; 377(26). PMID: 29226764    Free PMC article.
Highly Cited.
Integrating a 19F MRI Tracer Agent into the Clinical Scale Manufacturing of a T-Cell Immunotherapy.
Charles F O'Hanlon, Tamara Fedczyna, +2 authors, Brooke M Helfer.
Contrast Media Mol Imaging, 2017 Dec 13; 2017. PMID: 29230151    Free PMC article.
Increasing the Clinical Potential and Applications of Anti-HIV Antibodies.
Casey K Hua, Margaret E Ackerman.
Front Immunol, 2017 Dec 14; 8. PMID: 29234320    Free PMC article.
Review.
Immunotherapies for malignant glioma.
Vassiliki A Boussiotis, Alain Charest.
Oncogene, 2017 Dec 16; 37(9). PMID: 29242608    Free PMC article.
Review.
Regulation of T cell proliferation with drug-responsive microRNA switches.
Remus S Wong, Yvonne Y Chen, Christina D Smolke.
Nucleic Acids Res, 2017 Dec 16; 46(3). PMID: 29244152    Free PMC article.
Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial report.
Wen-Ying Zhang, Yao Wang, +12 authors, Wei-Dong Han.
Signal Transduct Target Ther, 2016 Mar 11; 1. PMID: 29263894    Free PMC article.
Safety Strategies of Genetically Engineered T Cells in Cancer Immunotherapy.
Yan-Bei Ren, Shang-Jun Sun, Shuang-Yin Han.
Curr Pharm Des, 2017 Dec 29; 24(1). PMID: 29283058    Free PMC article.
Review.
Measurable residual disease detection by high-throughput sequencing improves risk stratification for pediatric B-ALL.
Brent Wood, David Wu, +14 authors, Ilan Kirsch.
Blood, 2017 Dec 30; 131(12). PMID: 29284596    Free PMC article.
An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma.
Lydia Lee, Benjamin Draper, +15 authors, Martin Pule.
Blood, 2017 Dec 30; 131(7). PMID: 29284597    Free PMC article.
Highly Cited.
Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains.
Daniel T Harris, Marlies V Hager, +8 authors, David M Kranz.
J Immunol, 2017 Dec 31; 200(3). PMID: 29288199    Free PMC article.
mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting.
Jason J Lohmueller, James D Ham, Michael Kvorjak, Olivera J Finn.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296519    Free PMC article.
Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model.
Paola Bocca, Emma Di Carlo, +10 authors, Ignazia Prigione.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296542    Free PMC article.
Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice.
Marijn A Gillissen, Greta de Jong, +10 authors, Mette D Hazenberg.
Blood Adv, 2018 Jan 04; 1(19). PMID: 29296797    Free PMC article.
Blockade of CD7 expression in T cells for effective chimeric antigen receptor targeting of T-cell malignancies.
Yi Tian Png, Natasha Vinanica, +3 authors, Dario Campana.
Blood Adv, 2018 Jan 04; 1(25). PMID: 29296885    Free PMC article.
Immunotherapy for acute lymphoblastic leukemia: from famine to feast.
Kara L Davis, Crystal L Mackall.
Blood Adv, 2018 Jan 04; 1(3). PMID: 29296941    Free PMC article.
Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients.
Jiayi Yu, Xiaowen Wu, +11 authors, Jun Guo.
J Hematol Oncol, 2018 Jan 05; 11(1). PMID: 29298689    Free PMC article.
CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia.
Jinghua Wang, Siyu Chen, +18 authors, Penghui Zhou.
J Hematol Oncol, 2018 Jan 11; 11(1). PMID: 29316944    Free PMC article.
Highly Cited.
Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature.
Jean-François Gélinas, Deborah R Gill, Stephen C Hyde.
Microbiol Mol Biol Rev, 2018 Jan 13; 82(1). PMID: 29321222    Free PMC article.
Systematic Review.
Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.
Sonia Guedan, Avery D Posey, +14 authors, Carl H June.
JCI Insight, 2018 Jan 13; 3(1). PMID: 29321369    Free PMC article.
Highly Cited.
Allograft for Myeloma: Examining Pieces of the Jigsaw Puzzle.
Ehsan Malek, Najla El-Jurdi, Nicolaus Kröger, Marcos de Lima.
Front Oncol, 2018 Jan 13; 7. PMID: 29322027    Free PMC article.
Review.
Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.
Eric S Weiss, Charlotte Girard-Guyonvarc'h, +12 authors, Scott W Canna.
Blood, 2018 Jan 13; 131(13). PMID: 29326099    Free PMC article.
Highly Cited.
Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors.
Erhao Zhang, Jieyi Gu, Hanmei Xu.
Mol Cancer, 2018 Jan 14; 17(1). PMID: 29329591    Free PMC article.
Review.
Immunotherapy of cancer: targeting cancer during active disease or during dormancy?
Syed Ammer Shah, Melika Zarei, +3 authors, Masoud H Manjili.
Immunotherapy, 2018 Jan 18; 9(11). PMID: 29338608    Free PMC article.
Review.
Mechanogenetics for the remote and noninvasive control of cancer immunotherapy.
Yijia Pan, Sangpil Yoon, +9 authors, Yingxiao Wang.
Proc Natl Acad Sci U S A, 2018 Jan 19; 115(5). PMID: 29343642    Free PMC article.
Highly Cited.
Posttransplant chimeric antigen receptor therapy.
Melody Smith, Johannes Zakrzewski, Scott James, Michel Sadelain.
Blood, 2018 Jan 24; 131(10). PMID: 29358181    Free PMC article.
Review.
A novel Epstein-Barr virus-latent membrane protein-1-specific T-cell receptor for TCR gene therapy.
Hyun-Il Cho, Un-Hee Kim, +4 authors, Tai-Gyu Kim.
Br J Cancer, 2018 Jan 24; 118(4). PMID: 29360818    Free PMC article.
Mass spectrometry analysis reveals differences in the host cell protein species found in pseudotyped lentiviral vectors.
Sabine Johnson, Jun X Wheeler, +3 authors, Yuan Zhao.
Biologicals, 2018 Jan 24; 52. PMID: 29361371    Free PMC article.
Cancer immunology and melanoma immunotherapy.
Rudinei Diogo Marques Linck, Rômulo Leopoldo de Paula Costa, Bernardo Garicochea.
An Bras Dermatol, 2018 Jan 25; 92(6). PMID: 29364441    Free PMC article.
Review.
Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules.
Jianjian Jin, Nikolaos Gkitsas, +5 authors, Steven L Highfill.
J Transl Med, 2018 Jan 26; 16(1). PMID: 29368612    Free PMC article.
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.
Shannon L Maude, Theodore W Laetsch, +32 authors, Stephan A Grupp.
N Engl J Med, 2018 Feb 01; 378(5). PMID: 29385370    Free PMC article.
Highly Cited.
Nanobody Based Dual Specific CARs.
Stijn De Munter, Joline Ingels, +6 authors, Bart Vandekerckhove.
Int J Mol Sci, 2018 Feb 02; 19(2). PMID: 29385713    Free PMC article.
Current status and progress of lymphoma management in China.
Yuankai Shi.
Int J Hematol, 2018 Feb 02; 107(4). PMID: 29388166
Review.
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression.
Chungyong Han, Su-Jung Sim, +11 authors, Byoung S Kwon.
Nat Commun, 2018 Feb 03; 9(1). PMID: 29391449    Free PMC article.
Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines.
Edmund K Moon, Liang-Chuan S Wang, +4 authors, Steven M Albelda.
Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399394    Free PMC article.
A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.
Yuki Kagoya, Shinya Tanaka, +6 authors, Naoto Hirano.
Nat Med, 2018 Feb 06; 24(3). PMID: 29400710    Free PMC article.
Highly Cited.
Antitumor activity of EGFR-specific CAR T cells against non-small-cell lung cancer cells in vitro and in mice.
He Li, Yao Huang, +10 authors, Qi-Jun Qian.
Cell Death Dis, 2018 Feb 09; 9(2). PMID: 29415996    Free PMC article.
Antitumor effects and persistence of a novel HER2 CAR T cells directed to gastric cancer in preclinical models.
Yali Han, Chuanyong Liu, +9 authors, Meili Sun.
Am J Cancer Res, 2018 Feb 09; 8(1). PMID: 29416924    Free PMC article.
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Maliha Khan, Selena Carmona, +17 authors, Gheath Alatrash.
Front Immunol, 2018 Feb 10; 8. PMID: 29422892    Free PMC article.
Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward.
Jian Li, Wenwen Li, +3 authors, Qi Zhao.
J Hematol Oncol, 2018 Feb 13; 11(1). PMID: 29433552    Free PMC article.
Highly Cited. Review.
Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit 'ALL'.
David T Teachey, Michael R Bishop, David G Maloney, Stephan A Grupp.
Nat Rev Clin Oncol, 2018 Feb 13; 15(4). PMID: 29434335
IL-2 and Beyond in Cancer Immunotherapy.
John M Wrangle, Alicia Patterson, +7 authors, Mark P Rubinstein.
J Interferon Cytokine Res, 2018 Feb 15; 38(2). PMID: 29443657    Free PMC article.
Review.
Pleural cavity cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy: A case report.
Lijuan Ding, Yongxian Hu, +5 authors, He Huang.
Medicine (Baltimore), 2018 Feb 15; 97(7). PMID: 29443792    Free PMC article.
Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo.
Nigel G Kooreman, Youngkyun Kim, +16 authors, Joseph C Wu.
Cell Stem Cell, 2018 Feb 20; 22(4). PMID: 29456158    Free PMC article.
Highly Cited.
A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia.
Jianyu Weng, Peilong Lai, +20 authors, Xin Du.
J Hematol Oncol, 2018 Feb 21; 11(1). PMID: 29458388    Free PMC article.
Current Status of Gene Engineering Cell Therapeutics.
Aurore Saudemont, Laurent Jespers, Timothy Clay.
Front Immunol, 2018 Feb 21; 9. PMID: 29459866    Free PMC article.
Review.
T-cell Immunotherapies and the Role of Nonclinical Assessment: The Balance between Efficacy and Pathology.
Michaela E Sharpe.
Toxicol Pathol, 2018 Feb 24; 46(2). PMID: 29471776    Free PMC article.
Review.
PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells.
Wenting Zheng, Carol E O'Hear, +6 authors, Terrence L Geiger.
Leukemia, 2018 Feb 27; 32(5). PMID: 29479065    Free PMC article.
Engineering Axl specific CAR and SynNotch receptor for cancer therapy.
Jang Hwan Cho, Atsushi Okuma, +3 authors, Wilson W Wong.
Sci Rep, 2018 Mar 03; 8(1). PMID: 29497107    Free PMC article.
Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer.
Rohtesh S Mehta, Katayoun Rezvani.
Front Immunol, 2018 Mar 03; 9. PMID: 29497427    Free PMC article.
Highly Cited. Review.
Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel.
David Porter, Noelle Frey, +2 authors, Stephan A Grupp.
J Hematol Oncol, 2018 Mar 04; 11(1). PMID: 29499750    Free PMC article.
Highly Cited. Review.
Quarter Century of Anti-HIV CAR T Cells.
Thor A Wagner.
Curr HIV/AIDS Rep, 2018 Mar 04; 15(2). PMID: 29500712    Free PMC article.
Review.
In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia.
Zhi Cheng, Runhong Wei, +15 authors, Pin Wang.
Mol Ther, 2018 Mar 06; 26(4). PMID: 29503204    Free PMC article.
Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells.
Alexei F Kirkin, Karine N Dzhandzhugazyan, +14 authors, Walter Fischer.
Nat Commun, 2018 Mar 08; 9(1). PMID: 29511178    Free PMC article.
T-bet promotes potent antitumor activity of CD4+ CAR T cells.
Albert T Gacerez, Charles L Sentman.
Cancer Gene Ther, 2018 Mar 09; 25(5-6). PMID: 29515240    Free PMC article.
Chimeric Antigen Receptor T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia.
Ciprian Tomuleasa, Shigeo Fuji, +13 authors, Shigehisa Kitano.
Front Immunol, 2018 Mar 09; 9. PMID: 29515572    Free PMC article.
Review.
Chimeric Antigen Receptor T Cell Therapy and the Kidney: What the Nephrologist Needs to Know.
Kenar D Jhaveri, Mitchell H Rosner.
Clin J Am Soc Nephrol, 2018 Mar 11; 13(5). PMID: 29523675    Free PMC article.
CD19 CAR-T cell therapy for relapsed/refractory acute lymphoblastic leukemia: factors affecting toxicities and long-term efficacies.
Li-Na Zhang, Yongping Song, Delong Liu.
J Hematol Oncol, 2018 Mar 17; 11(1). PMID: 29544528    Free PMC article.
Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide.
Erhao Zhang, Jieyi Gu, +9 authors, Hanmei Xu.
J Hematol Oncol, 2018 Mar 22; 11(1). PMID: 29558951    Free PMC article.
Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model.
Sharon Wei Ling Lee, Giulia Adriani, +5 authors, Siew Cheng Wong.
Front Immunol, 2018 Mar 22; 9. PMID: 29559973    Free PMC article.
Immunomodulation in hepatocellular cancer.
Sunyoung Lee, Matthew Loecher, Renuka Iyer.
J Gastrointest Oncol, 2018 Mar 23; 9(1). PMID: 29564186    Free PMC article.
Review.
An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters.
Neha Bhagwat, Keely Dulmage, +12 authors, Erica L Carpenter.
Sci Rep, 2018 Mar 24; 8(1). PMID: 29568081    Free PMC article.
The development of CAR design for tumor CAR-T cell therapy.
Dandan Xu, Guoliang Jin, +5 authors, Junnian Zheng.
Oncotarget, 2018 Mar 24; 9(17). PMID: 29568411    Free PMC article.
Review.
Current Strategies to Enhance Anti-Tumour Immunity.
Katherine W Cook, Lindy G Durrant, Victoria A Brentville.
Biomedicines, 2018 Mar 24; 6(2). PMID: 29570634    Free PMC article.
Review.
Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support.
Jacob R Miller, Warren Isakow, +4 authors, Akinobu Itoh.
Case Rep Crit Care, 2018 Mar 30; 2018. PMID: 29593914    Free PMC article.
Strategies targeting cellular senescence.
Yossi Ovadya, Valery Krizhanovsky.
J Clin Invest, 2018 Apr 03; 128(4). PMID: 29608140    Free PMC article.
Highly Cited. Review.
Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy.
Chi Zhang, Yanchun Peng, +2 authors, Tao Dong.
Sci Rep, 2018 Apr 05; 8(1). PMID: 29615718    Free PMC article.
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.
Keisuke Watanabe, Yanping Luo, +12 authors, Carl H June.
JCI Insight, 2018 Apr 06; 3(7). PMID: 29618658    Free PMC article.
Highly Cited.
FDA Approval Summary: Tocilizumab for Treatment of Chimeric Antigen Receptor T Cell-Induced Severe or Life-Threatening Cytokine Release Syndrome.
Robert Q Le, Liang Li, +6 authors, Richard Pazdur.
Oncologist, 2018 Apr 07; 23(8). PMID: 29622697    Free PMC article.
Highly Cited.
Versatile CAR T-cells for cancer immunotherapy.
Fuliang Chu, Jingjing Cao, Sattva S Neelalpu.
Contemp Oncol (Pozn), 2018 Apr 10; 22(1A). PMID: 29628798    Free PMC article.
Review.
Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells.
Qian Mu, Miao Jiang, +11 authors, Dongqi Tang.
Onco Targets Ther, 2018 Apr 18; 11. PMID: 29662316    Free PMC article.
Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.
Benjamin Y Jin, Tracy E Campbell, +7 authors, Christian S Hinrichs.
JCI Insight, 2018 Apr 20; 3(8). PMID: 29669936    Free PMC article.
MYCN is a novel oncogenic target in adult B-ALL that activates the Wnt/β-catenin pathway by suppressing DKK3.
Desheng Kong, Linlin Zhao, +11 authors, Yinghua Li.
J Cell Mol Med, 2018 Apr 20; 22(7). PMID: 29673070    Free PMC article.
Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium.
Andrew R Medvec, Christopher Ecker, +4 authors, James L Riley.
Mol Ther Methods Clin Dev, 2018 Apr 25; 8. PMID: 29687031    Free PMC article.
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses.
Jang Hwan Cho, James J Collins, Wilson W Wong.
Cell, 2018 May 01; 173(6). PMID: 29706540    Free PMC article.
Highly Cited.
Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells.
Anandani Nellan, Christopher Rota, +6 authors, Daniel W Lee.
J Immunother Cancer, 2018 May 02; 6(1). PMID: 29712574    Free PMC article.
Interleukin-6: designing specific therapeutics for a complex cytokine.
Christoph Garbers, Sylvia Heink, Thomas Korn, Stefan Rose-John.
Nat Rev Drug Discov, 2018 May 05; 17(6). PMID: 29725131
Highly Cited. Review.
Immunotherapies: Exploiting the Immune System for Cancer Treatment.
Jeffrey Koury, Mariana Lucero, +8 authors, Andrew Tran.
J Immunol Res, 2018 May 05; 2018. PMID: 29725606    Free PMC article.
Review.
Strategies for enhancing adoptive T-cell immunotherapy against solid tumors using engineered cytokine signaling and other modalities.
Thomas Shum, Robert L Kruse, Cliona M Rooney.
Expert Opin Biol Ther, 2018 May 05; 18(6). PMID: 29727246    Free PMC article.
Review.
Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis.
Leslie S Kean.
Blood, 2018 May 08; 131(24). PMID: 29728399    Free PMC article.
Review.
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study.
Weili Sun, Jemily Malvar, +27 authors, James A Whitlock.
Leukemia, 2018 May 08; 32(11). PMID: 29728694    Free PMC article.
Chimeric antigen receptor T cell therapy in pancreatic cancer: from research to practice.
Vishal Jindal, Ena Arora, Muhammad Masab, Sorab Gupta.
Med Oncol, 2018 May 08; 35(6). PMID: 29728788
Review.
Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice.
Christopher A Pennell, Jessie L Barnum, +15 authors, Bruce R Blazar.
Mol Ther, 2018 May 08; 26(6). PMID: 29735365    Free PMC article.
CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation.
Pradip Bajgain, Supannikar Tawinwung, +7 authors, Juan F Vera.
J Immunother Cancer, 2018 May 12; 6(1). PMID: 29747685    Free PMC article.
Apoptosis of CD19+ chimeric antigen receptor T cells after treatment with chemotherapeutic agents.
Wenfang Yi, Fuyu Pei, +9 authors, Chunfu Li.
Mol Med Rep, 2018 May 12; 18(1). PMID: 29749441    Free PMC article.
Advances on chimeric antigen receptor-modified T-cell therapy for oncotherapy.
Yanyu Pang, Xiaoyang Hou, +2 authors, Guan Jiang.
Mol Cancer, 2018 May 18; 17(1). PMID: 29769134    Free PMC article.
Review.
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity.
Dongrui Wang, Brenda Aguilar, +6 authors, Christine E Brown.
JCI Insight, 2018 May 18; 3(10). PMID: 29769444    Free PMC article.
Highly Cited.
Predicting Dangerous Rides in CAR T Cells: Bridging the Gap between Mice and Humans.
Marco Ruella, Carl H June.
Mol Ther, 2018 May 23; 26(6). PMID: 29784587    Free PMC article.
Bibliometric Analysis of Tumor Immunotherapy Studies.
Kaining Lu, Shan Yu, +9 authors, Yuyan Zhu.
Med Sci Monit, 2018 May 24; 24. PMID: 29790485    Free PMC article.
Adoptive cell transfer using autologous tumor infiltrating lymphocytes in gynecologic malignancies.
Paul Mayor, Kristen Starbuck, Emese Zsiros.
Gynecol Oncol, 2018 May 29; 150(2). PMID: 29803316    Free PMC article.
Review.
Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design.
Esther Drent, Renée Poels, +4 authors, Tuna Mutis.
PLoS One, 2018 May 31; 13(5). PMID: 29847570    Free PMC article.
Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies.
Shangjun Sun, He Hao, +2 authors, Yang Fu.
J Immunol Res, 2018 Jun 01; 2018. PMID: 29850622    Free PMC article.
Review.
Cancer immunotherapy: broadening the scope of targetable tumours.
Jitske van den Bulk, Els Me Verdegaal, Noel Fcc de Miranda.
Open Biol, 2018 Jun 08; 8(6). PMID: 29875199    Free PMC article.
Review.
Overcoming Resistance of Human Non-Hodgkin's Lymphoma to CD19-CAR CTL Therapy by Celecoxib and Histone Deacetylase Inhibitors.
Antoni Xavier Torres-Collado, Ali R Jazirehi.
Cancers (Basel), 2018 Jun 16; 10(6). PMID: 29904021    Free PMC article.
Pediatric Cancer Immunotherapy: Opportunities and Challenges.
Mary Frances Wedekind, Nicholas L Denton, Chun-Yu Chen, Timothy P Cripe.
Paediatr Drugs, 2018 Jun 28; 20(5). PMID: 29948928    Free PMC article.
Review.
Shining light on advanced NSCLC in 2017: combining immune checkpoint inhibitors.
Meng Qiao, Tao Jiang, Caicun Zhou.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951304    Free PMC article.
Review.
Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future.
Mark A Perazella, Anushree C Shirali.
J Am Soc Nephrol, 2018 Jul 01; 29(8). PMID: 29959196    Free PMC article.
Highly Cited. Review.
Manipulating the tumor microenvironment by adoptive cell transfer of CAR T-cells.
Kavitha Gowrishankar, Lucy Birtwistle, Kenneth Micklethwaite.
Mamm Genome, 2018 Jul 11; 29(11-12). PMID: 29987406
Review.
CART cells are prone to Fas- and DR5-mediated cell death.
Benjamin O Tschumi, Nina Dumauthioz, +8 authors, Alena Donda.
J Immunother Cancer, 2018 Jul 15; 6(1). PMID: 30005714    Free PMC article.
The promise and challenges of chimeric antigen receptor T cells in relapsed B-cell acute lymphoblastic leukemia.
Zhi-Chun Ding.
Ann Transl Med, 2018 Jul 20; 6(11). PMID: 30023398    Free PMC article.
Novel Therapies in Acute Lymphoblastic Leukemia.
Kathleen W Phelan, Anjali S Advani.
Curr Hematol Malig Rep, 2018 Aug 06; 13(4). PMID: 30078158
Review.
CAR T Cells with Enhanced Sensitivity to B Cell Maturation Antigen for the Targeting of B Cell Non-Hodgkin's Lymphoma and Multiple Myeloma.
Julia Bluhm, Elisa Kieback, +7 authors, Armin Rehm.
Mol Ther, 2018 Aug 07; 26(8). PMID: 30078440    Free PMC article.
B-cell lymphoblastic leukemia in a 30-year-old male with back pain and thrombocytopenia.
Emilia Calvaresi, Syed Anwaruddin, Krishnarao Tangella, Janet Jokela.
Carle Sel Pap, 2017 Jan 01; 60(1). PMID: 30078916    Free PMC article.
Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity.
Ye Li, David L Hermanson, Branden S Moriarity, Dan S Kaufman.
Cell Stem Cell, 2018 Aug 08; 23(2). PMID: 30082067    Free PMC article.
Highly Cited.
Integration Mapping of piggyBac-Mediated CD19 Chimeric Antigen Receptor T Cells Analyzed by Novel Tagmentation-Assisted PCR.
Motoharu Hamada, Nobuhiro Nishio, +19 authors, Yoshiyuki Takahashi.
EBioMedicine, 2018 Aug 08; 34. PMID: 30082227    Free PMC article.
Therapeutic Vaccines for Genitourinary Malignancies.
Giselle M A Dutcher, Mehmet Asim Bilen.
Vaccines (Basel), 2018 Aug 15; 6(3). PMID: 30103542    Free PMC article.
Review.
CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum.
Asen Bagashev, Elena Sotillo, +8 authors, Andrei Thomas-Tikhonenko.
Mol Cell Biol, 2018 Aug 15; 38(21). PMID: 30104252    Free PMC article.
Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells.
Reza Elahi, Elnaz Khosh, Safa Tahmasebi, Abdolreza Esmaeilzadeh.
Front Immunol, 2018 Aug 16; 9. PMID: 30108584    Free PMC article.
Review.
The application of CAR-T cell therapy in hematological malignancies: advantages and challenges.
Zijun Zhao, Yu Chen, +2 authors, Minhao Wu.
Acta Pharm Sin B, 2018 Aug 16; 8(4). PMID: 30109179    Free PMC article.
Review.
Molecular Approaches to Safe and Controlled Engineered T-cell Therapy.
R S Kalinin, A V Petukhov, +3 authors, A G Gabibov.
Acta Naturae, 2018 Aug 18; 10(2). PMID: 30116611    Free PMC article.
A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML.
Samuel John, Heyu Chen, +7 authors, Cheng Cheng Zhang.
Mol Ther, 2018 Aug 23; 26(10). PMID: 30131301    Free PMC article.
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies.
Hannah M Knochelmann, Aubrey S Smith, +3 authors, Chrystal M Paulos.
Front Immunol, 2018 Aug 25; 9. PMID: 30140266    Free PMC article.
Highly Cited. Review.
Precision medicine in pediatric oncology.
Stefan E G Burdach, Mike-Andrew Westhoff, Maximilian Felix Steinhauser, Klaus-Michael Debatin.
Mol Cell Pediatr, 2018 Sep 02; 5(1). PMID: 30171420    Free PMC article.
Review.
The biological basis and clinical symptoms of CAR-T therapy-associated toxicites.
Aleksei Titov, Alexey Petukhov, +8 authors, Nickolai A Barlev.
Cell Death Dis, 2018 Sep 06; 9(9). PMID: 30181581    Free PMC article.
Review.
CAR-T Cell Therapy: A Door Is Open to Find Innumerable Possibilities of Treatments for Cancer Patients
Lorena Perez-Amill, Berta Marzal, +2 authors, Beatriz Martín-Antonio.
Turk J Haematol, 2018 Sep 07; 35(4). PMID: 30185400    Free PMC article.
Review.
An RNA toolbox for cancer immunotherapy.
Fernando Pastor, Pedro Berraondo, +4 authors, Ignacio Melero.
Nat Rev Drug Discov, 2018 Sep 08; 17(10). PMID: 30190565
Highly Cited. Review.
Flow Cytometric Monitoring for Residual Disease in B Lymphoblastic Leukemia Post T Cell Engaging Targeted Therapies.
Sindhu Cherian, Maryalice Stetler-Stevenson.
Curr Protoc Cytom, 2018 Sep 14; 86(1). PMID: 30212602    Free PMC article.
Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations.
Matthew R Hart, Donovan J Anderson, +3 authors, Marshall S Horwitz.
PLoS Genet, 2018 Sep 15; 14(9). PMID: 30216339    Free PMC article.
Personal history of infections and immunotherapy: Unexpected links and possible therapeutic opportunities.
Camille Jacqueline, Nathalie Bonnefoy, +2 authors, Benjamin Roche.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221066    Free PMC article.
Review.
The potential of CAR T therapy for relapsed or refractory pediatric and young adult B-cell ALL.
Matthew H Forsberg, Amritava Das, Krishanu Saha, Christian M Capitini.
Ther Clin Risk Manag, 2018 Sep 21; 14. PMID: 30233192    Free PMC article.
Review.
In situ administration of cytokine combinations induces tumor regression in mice.
Jinyu Zhang, Haochen Jiang, Haiyun Zhang.
EBioMedicine, 2018 Oct 10; 37. PMID: 30297145    Free PMC article.
Adoptive cell transfer: new perspective treatment in veterinary oncology.
Joanna Katarzyna Bujak, Rafał Pingwara, Michelle Hase Nelson, Kinga Majchrzak.
Acta Vet Scand, 2018 Oct 12; 60(1). PMID: 30305130    Free PMC article.
Review.
In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin's Lymphomas.
Carlos A Ramos, Rayne Rouce, +18 authors, Gianpietro Dotti.
Mol Ther, 2018 Oct 13; 26(12). PMID: 30309819    Free PMC article.
Highly Cited.
[Immunological foundations of modern (tumor) immunotherapy].
T Bopp, H Schild.
Pathologe, 2018 Oct 18; 39(6). PMID: 30327859
Review.
Glypicans as Cancer Therapeutic Targets.
Nan Li, Wei Gao, Yi-Fan Zhang, Mitchell Ho.
Trends Cancer, 2018 Oct 26; 4(11). PMID: 30352677    Free PMC article.
Review.
Chimeric Antigen Receptors Based on Low Affinity Mutants of FcεRI Re-direct T Cell Specificity to Cells Expressing Membrane IgE.
Dana E Ward, Brittany L Fay, +2 authors, Zhengyu Ma.
Front Immunol, 2018 Oct 27; 9. PMID: 30364107    Free PMC article.
Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory.
Sophie Viaud, Jennifer S Y Ma, +10 authors, Travis S Young.
Proc Natl Acad Sci U S A, 2018 Oct 31; 115(46). PMID: 30373813    Free PMC article.
CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge.
Sonia Guedan, Ramon Alemany.
Front Immunol, 2018 Nov 09; 9. PMID: 30405639    Free PMC article.
Review.
Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology.
Keisuke Watanabe, Shunichiro Kuramitsu, Avery D Posey, Carl H June.
Front Immunol, 2018 Nov 13; 9. PMID: 30416506    Free PMC article.
Highly Cited. Review.
Engineering CAR-T Cells for Improved Function Against Solid Tumors.
Michael A Morgan, Axel Schambach.
Front Immunol, 2018 Nov 14; 9. PMID: 30420856    Free PMC article.
Review.
The Two-Faced Cytokine IL-6 in Host Defense and Diseases.
Masashi Narazaki, Tadamitsu Kishimoto.
Int J Mol Sci, 2018 Nov 15; 19(11). PMID: 30423923    Free PMC article.
Review.
Chimeric-Antigen-Receptor (CAR) T Cells and the Factors Influencing their Therapeutic Efficacy.
Victoria G Kravets, Yi Zhang, Hongxing Sun.
J Immunol Res Ther, 2017 Jun 01; 2(1). PMID: 30443604    Free PMC article.
A Review on Electroporation-Based Intracellular Delivery.
Junfeng Shi, Yifan Ma, +5 authors, Jing Xie.
Molecules, 2018 Nov 25; 23(11). PMID: 30469344    Free PMC article.
Review.
A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release.
Yiyang Xu, Zhiyuan Yang, +11 authors, Cheng Liu.
Cell Discov, 2018 Nov 28; 4. PMID: 30479831    Free PMC article.
Universal CARs, universal T cells, and universal CAR T cells.
Juanjuan Zhao, Quande Lin, Yongping Song, Delong Liu.
J Hematol Oncol, 2018 Nov 30; 11(1). PMID: 30482221    Free PMC article.
Highly Cited. Review.
No free rides: management of toxicities of novel immunotherapies in ALL, including financial.
Tania Jain, Mark R Litzow.
Blood Adv, 2018 Nov 30; 2(22). PMID: 30482769    Free PMC article.
Review.
Are CAR T cells better than antibody or HCT therapy in B-ALL?
Michael A Pulsipher.
Hematology Am Soc Hematol Educ Program, 2018 Dec 07; 2018(1). PMID: 30504287    Free PMC article.
Review.
No free rides: management of toxicities of novel immunotherapies in ALL, including financial.
Tania Jain, Mark R Litzow.
Hematology Am Soc Hematol Educ Program, 2018 Dec 07; 2018(1). PMID: 30504288    Free PMC article.
Review.
Acoustic mechanogenetics.
Yijia Pan, Sangpil Yoon, Linshan Zhu, Yingxiao Wang.
Curr Opin Biomed Eng, 2018 Dec 07; 7. PMID: 30506011    Free PMC article.
Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance.
Michael M Boyiadzis, Madhav V Dhodapkar, +9 authors, Michael R Bishop.
J Immunother Cancer, 2018 Dec 06; 6(1). PMID: 30514386    Free PMC article.
Review.
CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia.
Stephanie Vairy, Julia Lopes Garcia, Pierre Teira, Henrique Bittencourt.
Drug Des Devel Ther, 2018 Dec 07; 12. PMID: 30518999    Free PMC article.
Review.
DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells.
Ruocong Zhao, Lin Cheng, +15 authors, Peng Li.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546945    Free PMC article.
Targeting immune cells for cancer therapy.
Sin Yee Gun, Sharon Wei Ling Lee, Je Lin Sieow, Siew Cheng Wong.
Redox Biol, 2019 Mar 29; 25. PMID: 30917934    Free PMC article.
Highly Cited. Review.
IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression.
Jennifer L Rabe, Lori Gardner, +14 authors, Christopher C Porter.
Cancer Res, 2019 May 31; 79(14). PMID: 31142509    Free PMC article.
Genomics-Guided Immunotherapy for Precision Medicine in Cancer.
Shradha Mukherjee.
Cancer Biother Radiopharm, 2019 Jul 18; 34(8). PMID: 31314580    Free PMC article.
Review.
Multi-Specific CAR Targeting to Prevent Antigen Escape.
Zachary Walsh, Savannah Ross, Terry J Fry.
Curr Hematol Malig Rep, 2019 Jul 25; 14(5). PMID: 31332617
Review.
Comparation of CART19 and autologous stem-cell transplantation for refractory/relapsed non-Hodgkin's lymphoma.
Caixia Li, Ying Zhang, +18 authors, Depei Wu.
JCI Insight, 2019 Jul 25; 5. PMID: 31335321    Free PMC article.
Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development.
Marcel Maluski, Arnab Ghosh, +11 authors, Martin G Sauer.
J Clin Invest, 2019 Sep 04; 129(12). PMID: 31479431    Free PMC article.
Immunotherapy for pediatric brain tumors: past and present.
Jessica B Foster, Peter J Madsen, +6 authors, Angela J Waanders.
Neuro Oncol, 2019 Sep 11; 21(10). PMID: 31504801    Free PMC article.
Review.
Bispecific T-Cell Redirection versus Chimeric Antigen Receptor (CAR)-T Cells as Approaches to Kill Cancer Cells.
William R Strohl, Michael Naso.
Antibodies (Basel), 2019 Sep 24; 8(3). PMID: 31544847    Free PMC article.
Review.
New Insights into Immunotherapy Strategies for Treating Autoimmune Diabetes.
Miriam Cabello-Olmo, Miriam Araña, +3 authors, Miguel Barajas.
Int J Mol Sci, 2019 Sep 29; 20(19). PMID: 31561568    Free PMC article.
Review.
Management of cytokine release syndrome related to CAR-T cell therapy.
Hongli Chen, Fangxia Wang, +16 authors, Aili He.
Front Med, 2019 Oct 02; 13(5). PMID: 31571160
Highly Cited.
Current Perspectives in Cancer Immunotherapy.
Theodoulakis Christofi, Stavroula Baritaki, +2 authors, Apostolos Zaravinos.
Cancers (Basel), 2019 Oct 03; 11(10). PMID: 31575023    Free PMC article.
Review.
Mechanisms of failure of chimeric antigen receptor T-cell therapy.
Xiaoqing Li, Weihong Chen.
Curr Opin Hematol, 2019 Oct 03; 26(6). PMID: 31577606    Free PMC article.
Review.
CAR Talk: How Cancer-Specific CAR T Cells Can Instruct How to Build CAR T Cells to Cure HIV.
Gloria B Kim, Kristen Hege, James L Riley.
Front Immunol, 2019 Oct 16; 10. PMID: 31611880    Free PMC article.
Review.
Genetically engineered T cells for cancer immunotherapy.
Dan Li, Xue Li, +8 authors, Wei Wang.
Signal Transduct Target Ther, 2019 Oct 23; 4. PMID: 31637014    Free PMC article.
Review.
Defining potency of CAR+ T cells: Fast and furious or slow and steady.
Ivan Liadi, Harjeet Singh, +3 authors, Navin Varadarajan.
Oncoimmunology, 2018 May 07; 8(10). PMID: 31646063    Free PMC article.
Steering CAR T cells to distinguish friend from foe.
Hillary G Caruso, Amy B Heimberger, Laurence J N Cooper.
Oncoimmunology, 2018 Aug 06; 8(10). PMID: 31646067    Free PMC article.
Review.
Immunotherapeutic Challenges for Pediatric Cancers.
Brian Hutzen, Mohammed Ghonime, +7 authors, Kevin A Cassady.
Mol Ther Oncolytics, 2019 Oct 28; 15. PMID: 31650024    Free PMC article.
Review.
Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma.
Indu Ramachandran, Daniel E Lowther, +26 authors, Samik Basu.
J Immunother Cancer, 2019 Oct 28; 7(1). PMID: 31651363    Free PMC article.
Recent updates on CAR T clinical trials for multiple myeloma.
Quande Lin, Juanjuan Zhao, Yongping Song, Delong Liu.
Mol Cancer, 2019 Nov 07; 18(1). PMID: 31684964    Free PMC article.
Review.
More precisely defining risk peri-HCT in pediatric ALL: pre- vs post-MRD measures, serial positivity, and risk modeling.
Peter Bader, Emilia Salzmann-Manrique, +22 authors, Michael A Pulsipher.
Blood Adv, 2019 Nov 13; 3(21). PMID: 31714961    Free PMC article.
Chimeric Antigen Receptor-T Cell Therapy: Practical Considerations for Implementation in Europe.
Jochen Buechner, Marie José Kersten, +2 authors, Ulrich Jäger.
Hemasphere, 2018 Feb 02; 2(1). PMID: 31723747    Free PMC article.
Review.
CAR T Cells: A Snapshot on the Growing Options to Design a CAR.
Astrid Holzinger, Hinrich Abken.
Hemasphere, 2019 Nov 15; 3(1). PMID: 31723811    Free PMC article.
Review.
Chimeric Antigen Receptor T-Cell Therapy Clinical Results in Pediatric and Young Adult B-ALL.
Amanda M DiNofia, Shannon L Maude.
Hemasphere, 2019 Nov 15; 3(4). PMID: 31723849    Free PMC article.
Review.
Current Progress in CAR-T Cell Therapy for Solid Tumors.
Shuo Ma, Xinchun Li, +5 authors, Qijun Qian.
Int J Biol Sci, 2019 Nov 23; 15(12). PMID: 31754328    Free PMC article.
Review.
Cytokine Release Syndrome: Current Perspectives.
Hemant Murthy, Madiha Iqbal, Julio C Chavez, Mohamed A Kharfan-Dabaja.
Immunotargets Ther, 2019 Nov 23; 8. PMID: 31754614    Free PMC article.
Review.
Delivery strategies of cancer immunotherapy: recent advances and future perspectives.
Zhongwei Zhao, Liyun Zheng, +3 authors, Jiansong Ji.
J Hematol Oncol, 2019 Nov 30; 12(1). PMID: 31779642    Free PMC article.
Review.
In situ thermal ablation augments antitumor efficacy of adoptive T cell therapy.
Fumito Ito, Trupti D Vardam, +4 authors, Sharon S Evans.
Int J Hyperthermia, 2019 Dec 05; 36(sup1). PMID: 31795828    Free PMC article.
Mechanisms of Relapse After CD19 CAR T-Cell Therapy for Acute Lymphoblastic Leukemia and Its Prevention and Treatment Strategies.
Xinjie Xu, Qihang Sun, +8 authors, Yuhua Li.
Front Immunol, 2019 Dec 05; 10. PMID: 31798590    Free PMC article.
Review.
γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma.
Margot J Pont, Tyler Hill, +14 authors, Stanley R Riddell.
Blood, 2019 Sep 29; 134(19). PMID: 31558469    Free PMC article.
Highly Cited.
PiggyBac transposon system with polymeric gene carrier transfected into human T cells.
Yan Zheng, Zhan-Rong Li, +5 authors, Shuang-Yin Han.
Am J Transl Res, 2019 Dec 10; 11(11). PMID: 31814915    Free PMC article.
Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies.
Jiali Cheng, Lei Zhao, +5 authors, Jianfeng Zhou.
Front Oncol, 2019 Dec 12; 9. PMID: 31824840    Free PMC article.
Review.
Enterotoxins can support CAR T cells against solid tumors.
Bianca von Scheidt, Minyu Wang, +9 authors, Clare Y Slaney.
Proc Natl Acad Sci U S A, 2019 Nov 27; 116(50). PMID: 31767744    Free PMC article.
CD19 and CD70 Dual-Target Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Relapsed and Refractory Primary Central Nervous System Diffuse Large B-Cell Lymphoma.
Sanfang Tu, Xuan Zhou, +8 authors, Yuhua Li.
Front Oncol, 2019 Dec 24; 9. PMID: 31867275    Free PMC article.
Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions.
Lauren C Fleischer, H Trent Spencer, Sunil S Raikar.
J Hematol Oncol, 2019 Dec 31; 12(1). PMID: 31884955    Free PMC article.
Review.
MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)-Current Treatment Options. Is There a Role for CAR-T Cell Therapy?
Oliver Britten, Denise Ragusa, Sabrina Tosi, Yasser Mostafa Kamel.
Cells, 2019 Nov 02; 8(11). PMID: 31671855    Free PMC article.
Review.
TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance.
Yinmeng Yang, M Eric Kohler, +7 authors, Terry J Fry.
Sci Transl Med, 2017 Nov 24; 9(417). PMID: 29167392    Free PMC article.
Highly Cited.
Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy.
Sophia Stock, Michael Schmitt, Leopold Sellner.
Int J Mol Sci, 2019 Dec 15; 20(24). PMID: 31835562    Free PMC article.
Review.
Current advances in chimeric antigen receptor T-cell therapy for refractory/relapsed multiple myeloma.
He Huang, Heng-Wei Wu, Yong-Xian Hu.
J Zhejiang Univ Sci B, 2020 Jan 04; 21(1). PMID: 31898440    Free PMC article.
Review.
Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy.
Alyssa Sheih, Valentin Voillet, +14 authors, Cameron J Turtle.
Nat Commun, 2020 Jan 12; 11(1). PMID: 31924795    Free PMC article.
Mechanisms of and approaches to overcoming resistance to immunotherapy.
Liora Schultz, Rebecca Gardner.
Hematology Am Soc Hematol Educ Program, 2019 Dec 07; 2019(1). PMID: 31808880    Free PMC article.
Review.
Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy.
Rebecca A Gardner, Francesco Ceppi, +12 authors, Michael C Jensen.
Blood, 2019 Nov 08; 134(24). PMID: 31697826    Free PMC article.
Highly Cited.
Coating biomimetic nanoparticles with chimeric antigen receptor T cell-membrane provides high specificity for hepatocellular carcinoma photothermal therapy treatment.
Weijie Ma, Daoming Zhu, +13 authors, Yufeng Yuan.
Theranostics, 2020 Jan 16; 10(3). PMID: 31938065    Free PMC article.
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Florian Wiede, Kun-Hui Lu, +16 authors, Tony Tiganis.
EMBO J, 2019 Dec 06; 39(2). PMID: 31803974    Free PMC article.
Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging.
Suk Hyun Lee, Hyunsu Soh, +11 authors, Jin-Sook Ryu.
PLoS One, 2020 Jan 08; 15(1). PMID: 31910217    Free PMC article.
Evidence of long-lasting anti-CD19 activity of engrafted CD19 chimeric antigen receptor-modified T cells in a phase I study targeting pediatrics with acute lymphoblastic leukemia.
Futian Ma, Jin-Yuan Ho, +9 authors, Jianqiang Li.
Hematol Oncol, 2019 Aug 30; 37(5). PMID: 31465532    Free PMC article.
MUC1 as a target for CAR-T therapy in head and neck squamous cell carinoma.
Zi Mei, Kai Zhang, +4 authors, Yi Zhang.
Cancer Med, 2019 Dec 05; 9(2). PMID: 31800160    Free PMC article.
CD19 CAR T Cells for the Treatment of Pediatric Pre-B Cell Acute Lymphoblastic Leukemia.
Holly L Pacenta, Theodore W Laetsch, Samuel John.
Paediatr Drugs, 2019 Nov 22; 22(1). PMID: 31749131
Optimizing CAR-T Cell Manufacturing Processes during Pivotal Clinical Trials.
Seshu Tyagarajan, Tom Spencer, Jonathan Smith.
Mol Ther Methods Clin Dev, 2020 Jan 29; 16. PMID: 31988978    Free PMC article.
Review.
Durable Molecular Remission in a Lymphoid BP-CML Patient Harboring T315I Mutation Treated with Anti-CD19 CAR-T Therapy.
Lu Zhou, Huiping Shi, +10 authors, Hong Liu.
Onco Targets Ther, 2020 Jan 31; 12. PMID: 31997880    Free PMC article.
Immunotherapy in pediatric acute lymphoblastic leukemia.
Hiroto Inaba, Ching-Hon Pui.
Cancer Metastasis Rev, 2019 Dec 08; 38(4). PMID: 31811553    Free PMC article.
Review.
Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies.
David W Scott, Kathleen P Pratt.
Front Immunol, 2020 Feb 06; 10. PMID: 32010137    Free PMC article.
Review.
Management of toxicities associated with novel immunotherapy agents in acute lymphoblastic leukemia.
Tania Jain, Mark R Litzow.
Ther Adv Hematol, 2020 Feb 06; 11. PMID: 32010436    Free PMC article.
Review.
EBV-positive primary CNS lymphoma restricted to the conus medullaris in an immunocompetent host.
Reinier Alvarez, Matthew D Hall, +2 authors, Yazmin Odia.
Neurol Clin Pract, 2020 Feb 12; 9(6). PMID: 32042476    Free PMC article.
Cellular Immunotherapy in Lymphoma: Beyond CART Cells.
Mahmoud R Gaballa, Carlos A Ramos.
Curr Treat Options Oncol, 2020 Feb 13; 21(3). PMID: 32048071    Free PMC article.
Review.
A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor-positive cells.
Marco Ruella, David M Barrett, +8 authors, Saar I Gill.
Blood, 2019 Nov 09; 135(7). PMID: 31703119    Free PMC article.
Immunotherapies for pediatric cancer: current landscape and future perspectives.
Brian Hutzen, Siddhi Nath Paudel, +3 authors, Timothy P Cripe.
Cancer Metastasis Rev, 2019 Dec 13; 38(4). PMID: 31828566    Free PMC article.
Review.
The long road to the first FDA-approved gene therapy: chimeric antigen receptor T cells targeting CD19.
Peter Braendstrup, Bruce L Levine, Marco Ruella.
Cytotherapy, 2020 Feb 06; 22(2). PMID: 32014447    Free PMC article.
Review.
Controlling Cytokine Release Syndrome to Harness the Full Potential of CAR-Based Cellular Therapy.
Monica S Thakar, Tyce J Kearl, Subramaniam Malarkannan.
Front Oncol, 2020 Feb 23; 9. PMID: 32076597    Free PMC article.
Review.
Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment.
Ya Luo, Jiqiao Yang, +5 authors, Xuelei Ma.
Front Oncol, 2020 Feb 23; 10. PMID: 32083005    Free PMC article.
Review.
[Construction of specific artificial antigen-presenting cells for in vitro activation of CD19 chimeric antigen receptor T cells].
Yao-Jun Peng, Qi-Yan Wu, +2 authors, Hua-Feng Wei.
Nan Fang Yi Ke Da Xue Xue Bao, 2017 May 26; 37(5). PMID: 28539278    Free PMC article.
Cellular therapy: Immune-related complications.
Joseph H Oved, David M Barrett, David T Teachey.
Immunol Rev, 2019 Jul 30; 290(1). PMID: 31355491    Free PMC article.
Review.
Engineering for Success: Approaches to Improve Chimeric Antigen Receptor T Cell Therapy for Solid Tumors.
Melinda Mata, Stephen Gottschalk.
Drugs, 2019 Feb 24; 79(4). PMID: 30796733    Free PMC article.
Review.
Current Status and Future Perspectives of Immunotherapy for Locally Advanced or Metastatic Urothelial Carcinoma: A Comprehensive Review.
Tae Jin Kim, Kang Su Cho, Kyo Chul Koo.
Cancers (Basel), 2020 Jan 17; 12(1). PMID: 31940998    Free PMC article.
Review.
High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia.
Stephan Müller, Tobias Bexte, +8 authors, Evelyn Ullrich.
Front Immunol, 2020 Mar 03; 10. PMID: 32117200    Free PMC article.
Adolescent and young adult patients with cancer: a milieu of unique features.
Leonard Sender, Keri B Zabokrtsky.
Nat Rev Clin Oncol, 2015 May 27; 12(8). PMID: 26011488
Review.
Seven great achievements in pediatric research in the past 40 y.
Tina L Cheng, Nova Monteiro, +5 authors, Scott C Denne.
Pediatr Res, 2016 Aug 25; 80(3). PMID: 27556199
Aptamer-Engineered Natural Killer Cells for Cell-Specific Adaptive Immunotherapy.
Shuanghui Yang, Jianguo Wen, +8 authors, Youli Zu.
Small, 2019 Apr 27; 15(22). PMID: 31026116    Free PMC article.
An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells.
Justyna Jureczek, Ralf Bergmann, +7 authors, Anja Feldmann.
Sci Rep, 2019 Jul 25; 9(1). PMID: 31332252    Free PMC article.
T memory stem cells in health and disease.
Luca Gattinoni, Daniel E Speiser, Mathias Lichterfeld, Chiara Bonini.
Nat Med, 2017 Jan 07; 23(1). PMID: 28060797    Free PMC article.
Highly Cited. Review.
Metabolic reprograming of anti-tumor immunity.
Madhusudhanan Sukumar, Rigel J Kishton, Nicholas P Restifo.
Curr Opin Immunol, 2017 Apr 17; 46. PMID: 28412583    Free PMC article.
Review.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han.
J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595    Free PMC article.
Highly Cited. Review.
Eradication of Established Tumors by Chemically Self-Assembled Nanoring Labeled T Cells.
Jacob R Petersburg, Jingjing Shen, +6 authors, Carston R Wagner.
ACS Nano, 2018 May 25; 12(7). PMID: 29792808    Free PMC article.
Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response.
Jessica B Foster, Namrata Choudhari, +11 authors, David M Barrett.
Hum Gene Ther, 2018 Jul 20; 30(2). PMID: 30024272    Free PMC article.
Cancer immunotherapy with CAR-T cells - behold the future.
Charlotte Graham, Rebecca Hewitson, Antonio Pagliuca, Reuben Benjamin.
Clin Med (Lond), 2018 Aug 04; 18(4). PMID: 30072559    Free PMC article.
Neurotoxicity after CTL019 in a pediatric and young adult cohort.
Jacqueline S Gofshteyn, Pamela A Shaw, +10 authors, Jennifer L McGuire.
Ann Neurol, 2018 Sep 05; 84(4). PMID: 30178481    Free PMC article.
Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia.
Daniel G Guy, Geoffrey L Uy.
Curr Hematol Malig Rep, 2018 Oct 04; 13(6). PMID: 30280288    Free PMC article.
Review.
Hematopoietic Stem Cell Transplantation in the Era of Engineered Cell Therapy.
Jacob S Appelbaum, Filippo Milano.
Curr Hematol Malig Rep, 2018 Oct 04; 13(6). PMID: 30280289    Free PMC article.
Review.
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells.
Michelle L Saetersmoen, Quirin Hammer, +2 authors, Karl-Johan Malmberg.
Semin Immunopathol, 2018 Oct 27; 41(1). PMID: 30361801
Review.
Anti-CD19 Chimeric Antigen Receptor T Cell Therapies: Harnessing the Power of the Immune System to Fight Diffuse Large B Cell Lymphoma.
Robert Havard, Deborah M Stephens.
Curr Hematol Malig Rep, 2018 Oct 27; 13(6). PMID: 30362020
Review.
Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies.
Richard Burt, Dana Warcel, Adele K Fielding.
Hum Vaccin Immunother, 2018 Nov 02; 15(3). PMID: 30380973    Free PMC article.
Review.
Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.
Carter M Suryadevara, Rupen Desai, +12 authors, Luis Sanchez-Perez.
Clin Cancer Res, 2018 Nov 15; 25(1). PMID: 30425092    Free PMC article.
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts.
Rosalie M Sterner, Reona Sakemura, +20 authors, Saad S Kenderian.
Blood, 2018 Nov 23; 133(7). PMID: 30463995    Free PMC article.
Highly Cited.
Cell-based immunotherapy approaches for multiple myeloma.
Katharina Kriegsmann, Mark Kriegsmann, +5 authors, Michael Hundemer.
Br J Cancer, 2018 Dec 07; 120(1). PMID: 30518815    Free PMC article.
Review.
Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?
Jiaqiao Fan, Dong Shang, +3 authors, Jin-Ming Yang.
Theranostics, 2018 Dec 18; 8(20). PMID: 30555581    Free PMC article.
Review.
T-cell functionality testing is highly relevant to developing novel immuno-tracers monitoring T cells in the context of immunotherapies and revealed CD7 as an attractive target.
Kristine E Mayer, Sabine Mall, +14 authors, Angela M Krackhardt.
Theranostics, 2019 Jan 08; 8(21). PMID: 30613283    Free PMC article.
Delivery technologies for cancer immunotherapy.
Rachel S Riley, Carl H June, Robert Langer, Michael J Mitchell.
Nat Rev Drug Discov, 2019 Jan 10; 18(3). PMID: 30622344    Free PMC article.
Highly Cited. Review.
Cytokine Release Syndrome With the Novel Treatments of Acute Lymphoblastic Leukemia: Pathophysiology, Prevention, and Treatment.
Ibrahim Aldoss, Samer K Khaled, Elizabeth Budde, Anthony S Stein.
Curr Oncol Rep, 2019 Jan 23; 21(1). PMID: 30666425
Review.
Industry's Giant Leap Into Cellular Therapy: Catalyzing Chimeric Antigen Receptor T Cell (CAR-T) Immunotherapy.
Stacie Ittershagen, Solveig Ericson, +12 authors, David Lebwohl.
Curr Hematol Malig Rep, 2019 Jan 23; 14(1). PMID: 30666506
Review.
Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma.
Mojgan Djavaheri-Mergny, Sylvie Giuriato, Mario P Tschan, Magali Humbert.
Cells, 2019 Feb 02; 8(2). PMID: 30704144    Free PMC article.
Review.
Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells.
Alka Dwivedi, Atharva Karulkar, +2 authors, Rahul Purwar.
Front Immunol, 2019 Feb 05; 9. PMID: 30713539    Free PMC article.
Review.
Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia.
Delong Liu, Juanjuan Zhao, +2 authors, Ting Yang.
J Hematol Oncol, 2019 Feb 10; 12(1). PMID: 30736842    Free PMC article.
Review.
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.
Nicholas Aj Dawson, Caroline Lamarche, +10 authors, Megan K Levings.
JCI Insight, 2019 Feb 13; 4(6). PMID: 30753169    Free PMC article.
Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia.
Juanjuan Zhao, Yongping Song, Delong Liu.
J Hematol Oncol, 2019 Feb 16; 12(1). PMID: 30764841    Free PMC article.
Highly Cited. Review.
A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4+ T and Natural Killer Cells.
Hampartsoum B Barsoumian, Lalit Batra, +6 authors, Haval Shirwan.
Cancer Res, 2019 Feb 17; 79(4). PMID: 30770367    Free PMC article.
Granulocyte-macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators.
Mohit Sachdeva, Philippe Duchateau, +2 authors, Julien Valton.
J Biol Chem, 2019 Feb 26; 294(14). PMID: 30804212    Free PMC article.
Development of an Interleukin-12 Fusion Protein That Is Activated by Cleavage with Matrix Metalloproteinase 9.
Denise Skrombolas, Mark Sullivan, John G Frelinger.
J Interferon Cytokine Res, 2019 Mar 09; 39(4). PMID: 30848689    Free PMC article.
In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function.
Dongrui Wang, Renate Starr, +3 authors, Christine E Brown.
J Vis Exp, 2019 Mar 19; (144). PMID: 30882787    Free PMC article.
CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies.
Jonathan P Mochel, Stephen C Ekker, +8 authors, Saad S Kenderian.
AAPS J, 2019 Apr 10; 21(3). PMID: 30963322
Review.
Unintended consequences of evolution of the Common Terminology Criteria for Adverse Events.
Tamara P Miller, Brian T Fisher, +6 authors, Richard Aplenc.
Pediatr Blood Cancer, 2019 Apr 11; 66(7). PMID: 30968531    Free PMC article.
BCMA CAR T cells: the winding path to success.
Ivan Borrello, Philip H Imus.
J Clin Invest, 2019 Apr 30; 129(6). PMID: 31033482    Free PMC article.
Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell.
Jieming Zeng, Shin Yi Tang, Shu Wang.
PLoS One, 2019 May 10; 14(5). PMID: 31071196    Free PMC article.
Integrated cancer tissue engineering models for precision medicine.
Michael E Bregenzer, Eric N Horst, +4 authors, Geeta Mehta.
PLoS One, 2019 May 11; 14(5). PMID: 31075118    Free PMC article.
Review.
Combined Antitumor Effects of Sorafenib and GPC3-CAR T Cells in Mouse Models of Hepatocellular Carcinoma.
Xiuqi Wu, Hong Luo, +7 authors, Zonghai Li.
Mol Ther, 2019 May 13; 27(8). PMID: 31078430    Free PMC article.
Induced Pluripotent Stem Cell-Derived T Cells for Cancer Immunotherapy.
Sunny J Patel, Takayoshi Yamauchi, Fumito Ito.
Surg Oncol Clin N Am, 2019 May 14; 28(3). PMID: 31079802    Free PMC article.
Review.
The promise of Immuno-oncology: implications for defining the value of cancer treatment.
Howard L Kaufman, Michael B Atkins, +11 authors, Wendy K D Selig.
J Immunother Cancer, 2019 May 19; 7(1). PMID: 31101066    Free PMC article.
Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy.
Stefan Stoiber, Bruno L Cadilha, +3 authors, Sebastian Kobold.
Cells, 2019 May 22; 8(5). PMID: 31108883    Free PMC article.
Review.
Treatment of patients with relapsed or refractory CD19+ lymphoid disease with T lymphocytes transduced by RV-SFG.CD19.CD28.4-1BBzeta retroviral vector: a unicentre phase I/II clinical trial protocol.
Maria-Luisa Schubert, Anita Schmitt, +13 authors, Michael Schmitt.
BMJ Open, 2019 May 22; 9(5). PMID: 31110096    Free PMC article.
Immune precision medicine for cancer: a novel insight based on the efficiency of immune effector cells.
Jean-François Rossi, Patrice Céballos, Zhao-Yang Lu.
Cancer Commun (Lond), 2019 Jun 16; 39(1). PMID: 31200766    Free PMC article.
Review.
Transcriptome and Regulatory Network Analyses of CD19-CAR-T Immunotherapy for B-ALL.
Qiong Zhang, Hui Hu, +5 authors, An-Yuan Guo.
Genomics Proteomics Bioinformatics, 2019 Jun 16; 17(2). PMID: 31201998    Free PMC article.
Target selection for CAR-T therapy.
Jianshu Wei, Xiao Han, Jian Bo, Weidong Han.
J Hematol Oncol, 2019 Jun 22; 12(1). PMID: 31221182    Free PMC article.
Review.
Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors.
Nathaniel D Chu, Haixin Sarah Bi, +4 authors, Eric J Alm.
BMC Immunol, 2019 Jun 23; 20(1). PMID: 31226930    Free PMC article.
Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS.
Henrik Knecht, Tomas Reigl, +32 authors, EuroClonality-NGS Working Group.
Leukemia, 2019 Jun 23; 33(9). PMID: 31227779    Free PMC article.
NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices.
Hongqian Chu, Jian Zhao, +2 authors, Lele Li.
Nat Commun, 2019 Jun 30; 10(1). PMID: 31253798    Free PMC article.
Engineering switchable and programmable universal CARs for CAR T therapy.
Delong Liu, Juanjuan Zhao, Yongping Song.
J Hematol Oncol, 2019 Jul 06; 12(1). PMID: 31272471    Free PMC article.
Review.
Imaging CAR T cell therapy with PSMA-targeted positron emission tomography.
Il Minn, David J Huss, +9 authors, Martin G Pomper.
Sci Adv, 2019 Jul 10; 5(7). PMID: 31281894    Free PMC article.
Genomic modeling of hepatitis B virus integration frequency in the human genome.
Ondrej Podlaha, George Wu, +5 authors, Zhaoshi Jiang.
PLoS One, 2019 Jul 30; 14(7). PMID: 31356634    Free PMC article.
Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity.
Shengnan Yu, Ming Yi, Shuang Qin, Kongming Wu.
Mol Cancer, 2019 Aug 21; 18(1). PMID: 31429760    Free PMC article.
Review.
A Distinct Subset of Highly Proliferative and Lentiviral Vector (LV)-Transducible NK Cells Define a Readily Engineered Subset for Adoptive Cellular Therapy.
Rafijul Bari, Markus Granzin, +9 authors, Wing Leung.
Front Immunol, 2019 Sep 12; 10. PMID: 31507603    Free PMC article.
Preclinical development of T-cell receptor-engineered T-cell therapy targeting the 5T4 tumor antigen on renal cell carcinoma.
Yuexin Xu, Alicia J Morales, +4 authors, Scott S Tykodi.
Cancer Immunol Immunother, 2019 Nov 07; 68(12). PMID: 31686124    Free PMC article.
Single variable domains from the T cell receptor β chain function as mono- and bifunctional CARs and TCRs.
Julyun Oh, Dora Toledo Warshaviak, +7 authors, Alexander Kamb.
Sci Rep, 2019 Nov 23; 9(1). PMID: 31754147    Free PMC article.
Finding the Keys to the CAR: Identifying Novel Target Antigens for T Cell Redirection Immunotherapies.
Rebecca C Abbott, Ryan S Cross, Misty R Jenkins.
Int J Mol Sci, 2020 Jan 18; 21(2). PMID: 31947597    Free PMC article.
Review.
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial.
Daniel W Lee, James N Kochenderfer, +16 authors, Crystal L Mackall.
Lancet, 2014 Oct 17; 385(9967). PMID: 25319501    Free PMC article.
Highly Cited.
T Cell Reprogramming Against Cancer.
Samuel G Katz, Peter M Rabinovich.
Methods Mol Biol, 2019 Nov 30; 2097. PMID: 31776916    Free PMC article.
Review.
Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia.
Xin He, Zijie Feng, +9 authors, Xianxin Hua.
Blood, 2020 Jan 18; 135(10). PMID: 31951650    Free PMC article.
Advances in the development of chimeric antigen receptor-T-cell therapy in B-cell acute lymphoblastic leukemia.
Xian Zhang, Jing-Jing Li, Pei-Hua Lu.
Chin Med J (Engl), 2020 Jan 25; 133(4). PMID: 31977556    Free PMC article.
Review.
Mechanisms of Leukemia Immune Evasion and Their Role in Relapse After Haploidentical Hematopoietic Cell Transplantation.
Pier Edoardo Rovatti, Valentina Gambacorta, +2 authors, Luca Vago.
Front Immunol, 2020 Mar 12; 11. PMID: 32158444    Free PMC article.
Review.
[Chinese Experts Consensus on Immune Checkpoint Inhibitors for Non-small Cell Lung Cancer (2019 version)].
Caicun Zhou, Jie Wang, +13 authors, Shukui Qin.
Zhongguo Fei Ai Za Zhi, 2020 Feb 26; 23(2). PMID: 32093450    Free PMC article.
Flow Cytometric Minimal Residual Disease Analysis in Acute Leukemia: Current Status.
Pulkit Rastogi, Man Updesh Singh Sachdeva.
Indian J Hematol Blood Transfus, 2020 Mar 17; 36(1). PMID: 32174688    Free PMC article.
Review.
Overexpression of Mesothelin in Pancreatic Ductal Adenocarcinoma (PDAC).
Kai Le, Jia Wang, +4 authors, Bin Zhu.
Int J Med Sci, 2020 Mar 17; 17(4). PMID: 32174772    Free PMC article.
Inhibition of Cholesterol Esterification Enzyme Enhances the Potency of Human Chimeric Antigen Receptor T Cells against Pancreatic Carcinoma.
Lei Zhao, Yang Liu, +7 authors, Yunwei Wei.
Mol Ther Oncolytics, 2020 Mar 18; 16. PMID: 32181327    Free PMC article.
GD2 chimeric antigen receptor modified T cells in synergy with sub-toxic level of doxorubicin targeting osteosarcomas.
Monrat Chulanetra, Atthapan Morchang, +9 authors, Lung-Ji Chang.
Am J Cancer Res, 2020 Mar 21; 10(2). PMID: 32195035    Free PMC article.
Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy.
Kris M Mahadeo, Sajad J Khazal, +31 authors, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.
Nat Rev Clin Oncol, 2018 Aug 08; 16(1). PMID: 30082906    Free PMC article.
Highly Cited. Review.
Advances in Developing CAR T-Cell Therapy for HIV Cure.
Jinxin Qi, Chengchao Ding, Xian Jiang, Yong Gao.
Front Immunol, 2020 Mar 27; 11. PMID: 32210965    Free PMC article.
Review.
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer.
Emilie Picard, Chris P Verschoor, Grace W Ma, Graham Pawelec.
Front Immunol, 2020 Mar 27; 11. PMID: 32210966    Free PMC article.
Review.
Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma.
David A Bond, Emily Dotson, +3 authors, Kami Maddocks.
Clin Lymphoma Myeloma Leuk, 2018 Dec 31; 19(3). PMID: 30594446    Free PMC article.
Assessment of a multi-cytokine profile by a novel biochip-based assay allows correlation of cytokine profiles with clinical outcomes in adult recipients of umbilical cord blood transplantation.
Theodoros Karantanos, Haesook T Kim, +7 authors, Vassiliki A Boussiotis.
Bone Marrow Transplant, 2019 Oct 04; 55(9). PMID: 31578466    Free PMC article.
Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells.
Andrew M Stein, Stephan A Grupp, +13 authors, Carl H June.
CPT Pharmacometrics Syst Pharmacol, 2019 Mar 09; 8(5). PMID: 30848084    Free PMC article.
Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality.
Chi Zhang, Zhao Wu, +2 authors, Gui-Qiang Wang.
Int J Antimicrob Agents, 2020 Apr 03; 55(5). PMID: 32234467    Free PMC article.
Highly Cited.
State of the art in CAR T cell therapy for CD19+ B cell malignancies.
Matthew J Frigault, Marcela V Maus.
J Clin Invest, 2020 Apr 03; 130(4). PMID: 32235098    Free PMC article.
Review.
Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity.
Marine Cazaux, Capucine L Grandjean, +7 authors, Philippe Bousso.
J Exp Med, 2019 Apr 03; 216(5). PMID: 30936262    Free PMC article.
Highly Cited.
Peptide Super-Agonist Enhances T-Cell Responses to Melanoma.
Sarah A E Galloway, Garry Dolton, +13 authors, Andrew K Sewell.
Front Immunol, 2019 Apr 02; 10. PMID: 30930889    Free PMC article.
A general view of CD33+ leukemic stem cells and CAR-T cells as interesting targets in acute myeloblatsic leukemia therapy.
Ezzatollah Fathi, Raheleh Farahzadi, +2 authors, Ilja Vietor.
Blood Res, 2020 Apr 10; 55(1). PMID: 32269970    Free PMC article.
Review.
Fueling Cancer Immunotherapy With Common Gamma Chain Cytokines.
Connor J Dwyer, Hannah M Knochelmann, +7 authors, Chrystal M Paulos.
Front Immunol, 2019 Mar 08; 10. PMID: 30842774    Free PMC article.
Review.
New Approaches on Cancer Immunotherapy.
Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, Mien-Chie Hung.
Cold Spring Harb Perspect Med, 2019 Oct 17; 10(8). PMID: 31615865    Free PMC article.
Review.
Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth.
Chenjun Bai, Shanshan Gao, +8 authors, Ningsheng Shao.
Mol Ther Oncolytics, 2020 Apr 14; 17. PMID: 32280743    Free PMC article.
Expression of MAGE-A and NY-ESO-1 cancer/testis antigens is enriched in triple-negative invasive breast cancers.
Ashwini Raghavendra, Priyakshi Kalita-de Croft, +4 authors, Sunil R Lakhani.
Histopathology, 2018 Feb 22; 73(1). PMID: 29465777    Free PMC article.
Toward the development of true "off-the-shelf" synthetic T-cell immunotherapy.
Shoichi Iriguchi, Shin Kaneko.
Cancer Sci, 2018 Nov 30; 110(1). PMID: 30485606    Free PMC article.
Review.
Chimeric antigen receptor-T cells with cytokine neutralizing capacity.
Adrian H J Tan, Natasha Vinanica, Dario Campana.
Blood Adv, 2020 Apr 10; 4(7). PMID: 32271901    Free PMC article.
Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?
Bingwen Liu, Min Li, +2 authors, Yufei Xiang.
J Autoimmun, 2020 Apr 16; 111. PMID: 32291137    Free PMC article.
Highly Cited. Review.
Graft Engineering and Adoptive Immunotherapy: New Approaches to Promote Immune Tolerance After Hematopoietic Stem Cell Transplantation.
Alice Bertaina, Maria Grazia Roncarolo.
Front Immunol, 2019 Jul 30; 10. PMID: 31354695    Free PMC article.
Review.
CAR T cell therapy: newer approaches to counter resistance and cost.
Rajesh Kumar Yadav, Asgar Ali, +6 authors, Sadhana Sharma.
Heliyon, 2020 Apr 24; 6(4). PMID: 32322738    Free PMC article.
Review.
[Combination of Oncolytic Virotherapy and CAR T/NK Cell Therapy for the Treatment of Cancer].
G V Kochneva, G F Sivolobova, +2 authors, S V Kulemzin.
Mol Biol (Mosk), 2020 Mar 13; 54(1). PMID: 32163385
Review.
Novel stimulation strategy with autologous tumor cells to generate T cell receptor-engineered T cells in esophageal squamous cell carcinoma.
Liyi Zhang.
Thorac Cancer, 2020 Mar 20; 11(5). PMID: 32189470    Free PMC article.
Pediatric Cardio-Oncology: Development of Cancer Treatment-Related Cardiotoxicity and the Therapeutic Approach to Affected Patients.
Thomas D Ryan, Rajaram Nagarajan, Justin Godown.
Curr Treat Options Oncol, 2019 May 28; 20(7). PMID: 31129800
Review.
Translating IL-6 biology into effective treatments.
Ernest H Choy, Fabrizio De Benedetti, +3 authors, Tadamitsu Kishimoto.
Nat Rev Rheumatol, 2020 Apr 25; 16(6). PMID: 32327746    Free PMC article.
Review.
T-Cell Receptor-Based Immunotherapy for Hematologic Malignancies.
Melinda A Biernacki, Michelle Brault, Marie Bleakley.
Cancer J, 2019 May 29; 25(3). PMID: 31135525    Free PMC article.
Review.
Escape From ALL-CARTaz: Leukemia Immunoediting in the Age of Chimeric Antigen Receptors.
Sisi Zheng, Mukta Asnani, Andrei Thomas-Tikhonenko.
Cancer J, 2019 May 29; 25(3). PMID: 31135529    Free PMC article.
Review.
T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells.
Dong Yang, Bin Sun, +5 authors, Xudong Zhao.
J Immunother Cancer, 2019 Jul 11; 7(1). PMID: 31288857    Free PMC article.
Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion.
Mumtaz Y Balkhi.
Oncoimmunology, 2020 May 05; 9(1). PMID: 32363117    Free PMC article.
Review.
Chimeric antigen receptor T cell therapy comes to clinical practice.
D A Wall, J Krueger.
Curr Oncol, 2020 May 06; 27(Suppl 2). PMID: 32368181    Free PMC article.
Review.
Immunotherapy for Medulloblastoma: Current Perspectives.
Tanvir F Kabir, Charles A Kunos, John L Villano, Aman Chauhan.
Immunotargets Ther, 2020 May 06; 9. PMID: 32368525    Free PMC article.
Review.
EGFR-targeted CAR-T cells are potent and specific in suppressing triple-negative breast cancer both in vitro and in vivo.
Lin Xia, Zao-Zao Zheng, +5 authors, Wen Liu.
Clin Transl Immunology, 2020 May 07; 9(5). PMID: 32373345    Free PMC article.
The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells.
Muneyoshi Futami, Keisuke Suzuki, +7 authors, Arinobu Tojo.
PLoS One, 2020 Apr 23; 15(4). PMID: 32320454    Free PMC article.
Successful treatment of acute B lymphoblastic leukemia relapse in the skin and testicle by anti-CD19 CAR-T with IL-6 knocking down: a case report.
Ze-Fa Liu, Li-Yun Chen, +7 authors, Sheng-Li Xue.
Biomark Res, 2020 May 14; 8. PMID: 32399214    Free PMC article.
Paving the Way toward Successful Multiple Myeloma Treatment: Chimeric Antigen Receptor T-Cell Therapy.
Ewelina Grywalska, Barbara Sosnowska-Pasiarska, +3 authors, Jacek Roliński.
Cells, 2020 Apr 23; 9(4). PMID: 32316105    Free PMC article.
Review.
A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking.
Katherine J Susa, Tom Cm Seegar, Stephen C Blacklow, Andrew C Kruse.
Elife, 2020 Apr 28; 9. PMID: 32338599    Free PMC article.
T cell immunotherapy enhanced by designer biomaterials.
Zachary S Dunn, John Mac, Pin Wang.
Biomaterials, 2019 Jul 05; 217. PMID: 31271861    Free PMC article.
Review.
Oncologic Emergencies: Immune-Based Cancer Therapies and Complications.
Brit Long, Elizabeth Brém, Alex Koyfman.
West J Emerg Med, 2020 May 19; 21(3). PMID: 32421502    Free PMC article.
Review.
Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes.
James T England, Alym Abdulla, +8 authors, Luke Y C Chen.
Blood Rev, 2020 May 20; 45. PMID: 32425294    Free PMC article.
Review.
Biomarkers in individualized management of chimeric antigen receptor T cell therapy.
Mengyi Du, Parameswaran Hari, Yu Hu, Heng Mei.
Biomark Res, 2020 May 20; 8. PMID: 32426136    Free PMC article.
Review.
Talkin' Toxins: From Coley's to Modern Cancer Immunotherapy.
Robert D Carlson, John C Flickinger, Adam E Snook.
Toxins (Basel), 2020 Apr 15; 12(4). PMID: 32283684    Free PMC article.
Review.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
Review.
Characterization of novel dual tandem CD19/BCMA chimeric antigen receptor T cells to potentially treat multiple myeloma.
Liqing Kang, Jian Zhang, +13 authors, Lei Yu.
Biomark Res, 2020 May 22; 8. PMID: 32435496    Free PMC article.
Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer.
Ahmed M E Abdalla, Lin Xiao, +5 authors, Guang Yang.
Adv Sci (Weinh), 2020 May 23; 7(10). PMID: 32440473    Free PMC article.
Review.
Gene modification strategies for next-generation CAR T cells against solid cancers.
Yonggui Tian, Yilu Li, Yupei Shao, Yi Zhang.
J Hematol Oncol, 2020 May 20; 13(1). PMID: 32423475    Free PMC article.
Review.
Immunotherapeutic options for management of relapsed or refractory B-cell acute lymphoblastic leukemia: how to select newly approved agents?
Prajwal Dhakal, Jasleen Kaur, Krishna Gundabolu, Vijaya Raj Bhatt.
Leuk Lymphoma, 2019 Jul 19; 61(1). PMID: 31317803    Free PMC article.
COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies.
Deepak Atri, Hasan K Siddiqi, +3 authors, Erin A Bohula.
JACC Basic Transl Sci, 2020 Apr 16; 5(5). PMID: 32292848    Free PMC article.
Review.
The Advent of CAR T-Cell Therapy for Lymphoproliferative Neoplasms: Integrating Research Into Clinical Practice.
Marco Cerrano, Marco Ruella, +11 authors, Benedetto Bruno.
Front Immunol, 2020 Jun 02; 11. PMID: 32477359    Free PMC article.
Review.
Optimization of T-cell Receptor-Modified T Cells for Cancer Therapy.
Dylan J Drakes, Sarwish Rafiq, +4 authors, Renier J Brentjens.
Cancer Immunol Res, 2020 Mar 27; 8(6). PMID: 32209638    Free PMC article.
Colorectal cysts as a validating tool for CAR therapy.
Pierre Dillard, Maren Lie, +5 authors, Sébastien Wälchli.
BMC Biotechnol, 2020 Jun 04; 20(1). PMID: 32487146    Free PMC article.
Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies.
Yuru Nie, Weiqing Lu, +6 authors, Yuhua Li.
Biomark Res, 2020 Jun 10; 8. PMID: 32514351    Free PMC article.
Review.
The future of cancer immunotherapy: microenvironment-targeting combinations.
Yonina R Murciano-Goroff, Allison Betof Warner, Jedd D Wolchok.
Cell Res, 2020 May 30; 30(6). PMID: 32467593    Free PMC article.
CAR T-cell immunotherapy of B-cell malignancy: the story so far.
Leena Halim, John Maher.
Ther Adv Vaccines Immunother, 2020 Jun 12; 8. PMID: 32524070    Free PMC article.
Review.
Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies?
Catalin Constantinescu, Sergiu Pasca, +11 authors, Ciprian Tomuleasa.
J Immunother Cancer, 2020 Jun 01; 8(1). PMID: 32474415    Free PMC article.
Review.
A case report of fulminant cytokine release syndrome complicated by dermatomyositis after the combination therapy with immune checkpoint inhibitors.
Junichiro Ohira, Michi Kawamoto, Yoshio Sugino, Nobuo Kohara.
Medicine (Baltimore), 2020 Apr 14; 99(15). PMID: 32282733    Free PMC article.
Quantitative Control of Gene-Engineered T-Cell Activity through the Covalent Attachment of Targeting Ligands to a Universal Immune Receptor.
Nicholas G Minutolo, Prannda Sharma, +9 authors, Daniel J Powell.
J Am Chem Soc, 2020 Mar 20; 142(14). PMID: 32191035    Free PMC article.
Potential Role of Anti-interleukin (IL)-6 Drugs in the Treatment of COVID-19: Rationale, Clinical Evidence and Risks.
Salvatore Crisafulli, Valentina Isgrò, +2 authors, Gianluca Trifirò.
BioDrugs, 2020 Jun 20; 34(4). PMID: 32557214    Free PMC article.
Review.
Pre-clinical assessment of chimeric antigen receptor t cell therapy targeting CD19+ B cell malignancy.
Sheng-I Hu, Ming-Chin Ko, +6 authors, Hsin-Chung Lin.
Ann Transl Med, 2020 Jun 23; 8(9). PMID: 32566611    Free PMC article.
Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma.
Shruti Gupta, Harish Seethapathy, +9 authors, Meghan E Sise.
Am J Kidney Dis, 2020 Jan 25; 76(1). PMID: 31973908    Free PMC article.
Building a CAR Garage: Preparing for the Delivery of Commercial CAR T Cell Products at Memorial Sloan Kettering Cancer Center.
Karlo Perica, Kevin J Curran, Renier J Brentjens, Sergio A Giralt.
Biol Blood Marrow Transplant, 2018 Mar 03; 24(6). PMID: 29499327    Free PMC article.
Review.
CAR-T Cell Therapies: An Overview of Clinical Studies Supporting Their Approved Use against Acute Lymphoblastic Leukemia and Large B-Cell Lymphomas.
Aamir Ahmad, Shahab Uddin, Martin Steinhoff.
Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486160    Free PMC article.
Review.
T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation.
Devin L Harrison, Yun Fang, Jun Huang.
Front Phys, 2019 Apr 01; 7. PMID: 32601597    Free PMC article.
Cytokine Storms: Understanding COVID-19.
Nilam Mangalmurti, Christopher A Hunter.
Immunity, 2020 Jul 02; 53(1). PMID: 32610079    Free PMC article.
Review.
EGFRvIII-specific CAR-T cells produced by piggyBac transposon exhibit efficient growth suppression against hepatocellular carcinoma.
Yuan Ma, Yan Chen, +5 authors, Yan Zheng.
Int J Med Sci, 2020 Jul 07; 17(10). PMID: 32624697    Free PMC article.
Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy.
Sawsan Rashdan, John D Minna, David E Gerber.
Lancet Respir Med, 2018 Jun 02; 6(6). PMID: 29856320    Free PMC article.
Clinical trial design in neurofibromatosis type 1 as a model for other tumor predisposition syndromes.
Andrea M Gross, Brigitte C Widemann.
Neurooncol Adv, 2020 Jul 10; 2(Suppl 1). PMID: 32642739    Free PMC article.
Review.
[Construction of CD19-CAR retroviral vector and modification of its transduction of human T-lymphocytes].
Yang Wang, Gusheng Tang, +9 authors, Jianmin Yang.
Zhonghua Xue Ye Xue Za Zhi, 2015 Apr 29; 36(4). PMID: 25916298    Free PMC article.
[Cytotoxity of pomalidomide combined CAR-T cell for multiple myeloma cell RPMI8226 and U266].
Lei Wang, Shuting Zhang, Jianfeng Ou, Hai Bai.
Zhonghua Xue Ye Xue Za Zhi, 2015 Jul 03; 36(6). PMID: 26134016    Free PMC article.
[Chimeric antigen receptors T cells in treatment of a relapsed pediatric acute lymphoblastic leukemia, relapse after allogenetic hematopoietic stem cell transplantation: case report and review of literature review].
Yingxi Zuo, Jingbo Wang, +5 authors, Leping Zhang.
Zhonghua Xue Ye Xue Za Zhi, 2016 Mar 26; 37(2). PMID: 27014980    Free PMC article.
Review.
[Research progress of the side effect and application prospects of CAR-T cells in the treatment of malignant tumors].
Jinqi Li, Haihui Gu, Jianmin Yang, Baohua Qian.
Zhonghua Xue Ye Xue Za Zhi, 2016 Mar 26; 37(2). PMID: 27014992    Free PMC article.
[The consensus of allogeneic hematopoietic transplantation for hematological diseases in China(2016)-- post- transplant leukemia relapse].
Chinese Society of Hematology, Chinese Medical Association.
Zhonghua Xue Ye Xue Za Zhi, 2016 Nov 02; 37(10). PMID: 27801312    Free PMC article.
[Strategies for improving the outcomes of allogeneic stem cell transplantation in patients with relapsed acute leukemia].
Y Q Sun, X J Huang.
Zhonghua Xue Ye Xue Za Zhi, 2017 Sep 28; 38(8). PMID: 28954358    Free PMC article.
[The specific cytotoxicities of chimeric antigen receptor-engineered T cells on different lymphomas].
R Zhang, Q Deng, +2 authors, M F Zhao.
Zhonghua Xue Ye Xue Za Zhi, 2017 Nov 23; 38(10). PMID: 29166735    Free PMC article.
[Management of cytokine release syndrome during chimeric antigen receptor-modified T cell therapy].
H W Jiang, H Mei, Y Hu.
Zhonghua Xue Ye Xue Za Zhi, 2017 Nov 23; 38(10). PMID: 29166750    Free PMC article.
Convergent pathways of the hyperferritinemic syndromes.
Grant S Schulert, Scott W Canna.
Int Immunol, 2018 Feb 09; 30(5). PMID: 29420734    Free PMC article.
Review.
[An experimental study of CD4 targeted chimeric antigen receptor modified T cell with anti-lymphoma activity].
G H Chen, H W Huang, +14 authors, D P Wu.
Zhonghua Xue Ye Xue Za Zhi, 2018 Mar 22; 39(2). PMID: 29562451    Free PMC article.
[How I treat CAR-T cell therapy-related cytokine release syndrome].
A B Liang, P Li.
Zhonghua Xue Ye Xue Za Zhi, 2018 Jul 24; 39(6). PMID: 30032557    Free PMC article.
[Efficacy of anti-CD19 CAR-T cell therapy in 10 refractory recurrent B cell malignancies].
F Bao, K Hu, +2 authors, H M Jing.
Zhonghua Xue Ye Xue Za Zhi, 2018 Jul 24; 39(6). PMID: 30032559    Free PMC article.
[Construction and in vitro verification of a new humanized anti-CD19 CAR-T cells with high affinity].
C X Zhang, H Cheng, +5 authors, K L Xu.
Zhonghua Xue Ye Xue Za Zhi, 2018 Jul 24; 39(6). PMID: 30032561    Free PMC article.
[Chimeric antigen receptors T cells for treatment of 48 relapsed or refractory acute lymphoblastic leukemia children: long term follow-up outcomes].
Y X Zuo, Y P Jia, +5 authors, L P Zhang.
Zhonghua Xue Ye Xue Za Zhi, 2019 May 21; 40(4). PMID: 31104436    Free PMC article.
[Anti-CD22 CAR-T combined with anti-CD19 CAR-T cells in the treatment of relapsed or refractory acute B lymphocytic leukemia with severe cytokine release syndrome: two cases report and literature review].
L L Gao, L Huang, +6 authors, J F Zhou.
Zhonghua Xue Ye Xue Za Zhi, 2019 Oct 28; 40(9). PMID: 31648485    Free PMC article.
Review.
[Chimeric antigen receptors T cells for treatment of B-cell acute lymphoblastic leukemia previously infected with hepatitis B virus: two cases report and literatures review].
L Han, J Zhou, +4 authors, Y P Song.
Zhonghua Xue Ye Xue Za Zhi, 2020 Apr 22; 41(3). PMID: 32311897    Free PMC article.
Review.
The many faces of the anti-COVID immune response.
Santosha A Vardhana, Jedd D Wolchok.
J Exp Med, 2020 May 01; 217(6). PMID: 32353870    Free PMC article.
Highly Cited.
Cancer systems immunology.
Nathan E Reticker-Flynn, Edgar G Engleman.
Elife, 2020 Jul 14; 9. PMID: 32657757    Free PMC article.
Review.
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of multiple myeloma.
Nina Shah, Jack Aiello, +16 authors, Madhav Dhodapkar.
J Immunother Cancer, 2020 Jul 15; 8(2). PMID: 32661116    Free PMC article.
Dissecting the Tumor-Immune Landscape in Chimeric Antigen Receptor T-cell Therapy: Key Challenges and Opportunities for a Systems Immunology Approach.
Gregory M Chen, Andrew Azzam, +3 authors, Kai Tan.
Clin Cancer Res, 2020 Mar 05; 26(14). PMID: 32127393    Free PMC article.
Review.
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma.
Meenakshi Hegde, Sujith K Joseph, +22 authors, Nabil Ahmed.
Nat Commun, 2020 Jul 17; 11(1). PMID: 32669548    Free PMC article.