Journal Article
. 2013 Mar;31(14).
doi: 10.1200/JCO.2012.45.1096.

Biologic determinants of tumor recurrence in stage II colon cancer: validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581

Alan P Venook 1 Donna Niedzwiecki  Margarita Lopatin  Xing Ye  Mark Lee  Paula N Friedman  Wendy Frankel  Kim Clark-Langone  Carl Millward  Steven Shak  Richard M Goldberg  Najjia N Mahmoud  Robert S Warren  Richard L Schilsky  Monica M Bertagnolli  
Affiliations
  • PMID: 23530100
  •     43 References
  •     52 citations

Abstract

Purpose: A greater understanding of the biology of tumor recurrence should improve adjuvant treatment decision making. We conducted a validation study of the 12-gene recurrence score (RS), a quantitative assay integrating stromal response and cell cycle gene expression, in tumor specimens from patients enrolled onto Cancer and Leukemia Group B (CALGB) 9581.

Patients And Methods: CALGB 9581 randomly assigned 1,713 patients with stage II colon cancer to treatment with edrecolomab or observation and found no survival difference. The analysis reported here included all patients with available tissue and recurrence (n = 162) and a random (approximately 1:3) selection of nonrecurring patients. RS was assessed in 690 formalin-fixed paraffin-embedded tumor samples with quantitative reverse transcriptase polymerase chain reaction by using prespecified genes and a previously validated algorithm. Association of RS and recurrence was analyzed by weighted Cox proportional hazards regression.

Results: Continuous RS was significantly associated with risk of recurrence (P = .013) as was mismatch repair (MMR) gene deficiency (P = .044). In multivariate analyses, RS was the strongest predictor of recurrence (P = .004), independent of T stage, MMR, number of nodes examined, grade, and lymphovascular invasion. In T3 MMR-intact (MMR-I) patients, prespecified low and high RS groups had average 5-year recurrence risks of 13% (95% CI, 10% to 16%) and 21% (95% CI, 16% to 26%), respectively.

Conclusion: The 12-gene RS predicts recurrence in stage II colon cancer in CALGB 9581. This is consistent with the importance of stromal response and cell cycle gene expression in colon tumor recurrence. RS appears to be most discerning for patients with T3 MMR-I tumors, although markers such as grade and lymphovascular invasion did not add value in this subset of patients.

Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study.
Carmen J Allegra, Soon Paik, +7 authors, H Samuel Wieand.
J Clin Oncol, 2003 Jan 15; 21(2). PMID: 12525515
Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model.
Jonathan D Cheng, Roland L Dunbrack, +3 authors, Louis M Weiner.
Cancer Res, 2002 Aug 17; 62(16). PMID: 12183436
A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer.
Andrew M Scott, Greg Wiseman, +19 authors, Lloyd J Old.
Clin Cancer Res, 2003 May 10; 9(5). PMID: 12738716
Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions.
David H Berger, Christine A O'Mahony, +4 authors, R Daniel Beauchamp.
Surgery, 2003 May 30; 133(5). PMID: 12773985
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.
Christine M Ribic, Daniel J Sargent, +10 authors, Steven Gallinger.
N Engl J Med, 2003 Jul 18; 349(3). PMID: 12867608    Free PMC article.
Highly Cited.
Prognostic value of proliferation, apoptosis, defective DNA mismatch repair, and p53 overexpression in patients with resected Dukes' B2 or C colon cancer: a North Central Cancer Treatment Group Study.
Megan M Garrity, Lawrence J Burgart, +15 authors, North Central Cancer Treatment Group.
J Clin Oncol, 2004 May 01; 22(9). PMID: 15117979
Antibody targeting in metastatic colon cancer: a phase I study of monoclonal antibody F19 against a cell-surface protein of reactive tumor stromal fibroblasts.
S Welt, C R Divgi, +7 authors, L J Old.
J Clin Oncol, 1994 Jun 01; 12(6). PMID: 8201382
Stromal fibroblasts in cancer initiation and progression.
Neil A Bhowmick, Eric G Neilson, Harold L Moses.
Nature, 2004 Nov 19; 432(7015). PMID: 15549095    Free PMC article.
Highly Cited. Review.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta.
Hendrik Ungefroren, Stephanie Groth, +2 authors, Fred Fändrich.
J Biol Chem, 2004 Nov 18; 280(4). PMID: 15546867
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.
Howard Y Chang, Dimitry S A Nuyten, +10 authors, Marc J van de Vijver.
Proc Natl Acad Sci U S A, 2005 Feb 11; 102(10). PMID: 15701700    Free PMC article.
Highly Cited.
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG).
Lancet, 2005 May 17; 365(9472). PMID: 15894097
Highly Cited.
Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer.
Eeva Salminen, Salla Palmu, +2 authors, Karl-Owe Söderström.
World J Gastroenterol, 2005 Jun 02; 11(21). PMID: 15929175    Free PMC article.
Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake.
Markus Loeffler, Jörg A Krüger, Andreas G Niethammer, Ralph A Reisfeld.
J Clin Invest, 2006 Jun 24; 116(7). PMID: 16794736    Free PMC article.
Highly Cited.
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
Transforming growth factor-beta signaling in prostate stromal cells supports prostate carcinoma growth by up-regulating stromal genes related to tissue remodeling.
Erik V Verona, Abdel G Elkahloun, +3 authors, Lu-Zhe Sun.
Cancer Res, 2007 Jun 19; 67(12). PMID: 17575140
The carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage.
Wilma E Mesker, Jan M C Junggeburt, +4 authors, Rob A E M Tollenaar.
Cell Oncol, 2007 Aug 30; 29(5). PMID: 17726261    Free PMC article.
Adjuvant therapy for stage II colon cancer: prognostic and predictive markers.
Brian Vicuna, Al B Benson.
J Natl Compr Canc Netw, 2007 Nov 06; 5(9). PMID: 17977502
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.
Rafael G Amado, Michael Wolf, +9 authors, David D Chang.
J Clin Oncol, 2008 Mar 05; 26(10). PMID: 18316791
Highly Cited.
How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancer.
Bruce M Boman, Jeremy Z Fields, +2 authors, Olaf A Runquist.
Cancer Res, 2008 May 03; 68(9). PMID: 18451157
Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.
Jason R Neil, Kyle M Johnson, Raphael A Nemenoff, William P Schiemann.
Carcinogenesis, 2008 Aug 30; 29(11). PMID: 18725385    Free PMC article.
Lymphovascular invasion in colorectal cancer: an interobserver variability study.
Elizabeth I Harris, David N Lewin, +6 authors, Mary K Washington.
Am J Surg Pathol, 2008 Sep 10; 32(12). PMID: 18779725    Free PMC article.
Weighted analyses for cohort sampling designs.
Robert J Gray.
Lifetime Data Anal, 2008 Aug 21; 15(1). PMID: 18712477
Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer.
A Anjomshoaa, Y-H Lin, +10 authors, A E Reeve.
Br J Cancer, 2009 Feb 25; 99(6). PMID: 19238634    Free PMC article.
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.
Monica M Bertagnolli, Donna Niedzwiecki, +9 authors, Mark Redston.
J Clin Oncol, 2009 Mar 11; 27(11). PMID: 19273709    Free PMC article.
Highly Cited.
Use of archived specimens in evaluation of prognostic and predictive biomarkers.
Richard M Simon, Soonmyung Paik, Daniel F Hayes.
J Natl Cancer Inst, 2009 Oct 10; 101(21). PMID: 19815849    Free PMC article.
Highly Cited.
Molecular origins of cancer: Molecular basis of colorectal cancer.
Sanford D Markowitz, Monica M Bertagnolli.
N Engl J Med, 2009 Dec 19; 361(25). PMID: 20018966    Free PMC article.
Highly Cited. Review.
Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis.
Adelaide M Carothers, Jennifer S Davids, Beatrice C Damas, Monica M Bertagnolli.
Cancer Res, 2010 May 21; 70(11). PMID: 20484034    Free PMC article.
Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer.
Daniel J Sargent, Silvia Marsoni, +14 authors, Steven Gallinger.
J Clin Oncol, 2010 May 26; 28(20). PMID: 20498393    Free PMC article.
Highly Cited.
Clinical relevance of microsatellite instability in colorectal cancer.
Albert de la Chapelle, Heather Hampel.
J Clin Oncol, 2010 Jun 03; 28(20). PMID: 20516444    Free PMC article.
Highly Cited.
Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin.
Michael J O'Connell, Ian Lavery, +9 authors, Norman Wolmark.
J Clin Oncol, 2010 Aug 04; 28(25). PMID: 20679606    Free PMC article.
Highly Cited.
Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1.
Hoon Kim, John Watkinson, Vinay Varadan, Dimitris Anastassiou.
BMC Med Genomics, 2010 Nov 05; 3. PMID: 21047417    Free PMC article.
Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX Colon Cancer Assay.
Kim M Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar, Drew Watson.
BMC Cancer, 2010 Dec 24; 10. PMID: 21176237    Free PMC article.
Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer.
Robin K Kelley, Stephanie L Van Bebber, Kathryn A Phillips, Alan P Venook.
J Natl Compr Canc Netw, 2011 Jan 15; 9(1). PMID: 21233242    Free PMC article.
Review.
Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer.
Gordon Hutchins, Katie Southward, +9 authors, Philip Quirke.
J Clin Oncol, 2011 Mar 09; 29(10). PMID: 21383284
Highly Cited.
DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy.
Frank A Sinicrope, Nathan R Foster, +9 authors, Daniel J Sargent.
J Natl Cancer Inst, 2011 May 21; 103(11). PMID: 21597022    Free PMC article.
Highly Cited.
Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: results from CALGB 9581.
Donna Niedzwiecki, Monica M Bertagnolli, +17 authors, Thomas A Colacchio.
J Clin Oncol, 2011 Jul 13; 29(23). PMID: 21747085    Free PMC article.
Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?
Robin K Kelley, Alan P Venook.
Clin Colorectal Cancer, 2011 Aug 24; 10(2). PMID: 21859557    Free PMC article.
Review.
Gene expression following exposure to celecoxib in humans: pathways of inflammation and carcinogenesis are activated in tumors but not normal tissues.
Eyal Sagiv, Michal Sheffer, +5 authors, Nadir Arber.
Digestion, 2011 May 07; 84(3). PMID: 21546775
Validation study of a quantitative multigene reverse transcriptase-polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer.
Richard G Gray, Philip Quirke, +10 authors, David J Kerr.
J Clin Oncol, 2011 Nov 10; 29(35). PMID: 22067390
Highly Cited.
Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999.
C C Compton, L P Fielding, +12 authors, C Willett.
Arch Pathol Lab Med, 2000 Jul 11; 124(7). PMID: 10888773
Highly Cited. Review.
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.
D J Slamon, B Leyland-Jones, +9 authors, L Norton.
N Engl J Med, 2001 Mar 15; 344(11). PMID: 11248153
Highly Cited.
Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer.
R-D Hofheinz, S-E al-Batran, +8 authors, G Stehle.
Onkologie, 2003 Mar 08; 26(1). PMID: 12624517
Publicly funded clinical trials and the future of cancer care.
Richard L Schilsky.
Oncologist, 2013 Feb 01; 18(2). PMID: 23363807    Free PMC article.
Analytical validation of the Oncotype DX prostate cancer assay - a clinical RT-PCR assay optimized for prostate needle biopsies.
Dejan Knezevic, Audrey D Goddard, +8 authors, Christopher Quale.
BMC Genomics, 2013 Oct 10; 14. PMID: 24103217    Free PMC article.
Highly Cited.
Genome-wide multi-omics profiling of colorectal cancer identifies immune determinants strongly associated with relapse.
Subha Madhavan, Yuriy Gusev, +12 authors, Louis M Weiner.
Front Genet, 2013 Dec 07; 4. PMID: 24312117    Free PMC article.
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Jason Chan, Michael T Kinsella, +9 authors, Timothy J Kinsella.
Front Oncol, 2013 Dec 11; 3. PMID: 24324931    Free PMC article.
DNA testing and molecular screening for colon cancer.
John M Carethers.
Clin Gastroenterol Hepatol, 2013 Dec 21; 12(3). PMID: 24355100    Free PMC article.
Review.
Colorectal cancer surveillance: what's new and what's next.
Johnie Rose, Knut Magne Augestad, Gregory S Cooper.
World J Gastroenterol, 2014 Mar 04; 20(8). PMID: 24587668    Free PMC article.
Review.
Future directions for the early detection of colorectal cancer recurrence.
Avery S Walker, Eric K Johnson, +5 authors, Scott R Steele.
J Cancer, 2014 May 03; 5(4). PMID: 24790655    Free PMC article.
Review.
Do the benefits outweigh the side effects of colorectal cancer surveillance? A systematic review.
Knut Magne Augestad, Johnie Rose, +2 authors, Conor Delaney.
World J Gastrointest Oncol, 2014 May 17; 6(5). PMID: 24834140    Free PMC article.
Review.
Bevacizumab terminates homeobox B9-induced tumor proliferation by silencing microenvironmental communication.
Yoshinori Hoshino, Tetsu Hayashida, +9 authors, Yuko Kitagawa.
Mol Cancer, 2014 Jun 03; 13. PMID: 24885802    Free PMC article.
Evolving role of gene expression signatures as biomarkers in early-stage colon cancer.
Gaurav Goel.
J Gastrointest Cancer, 2014 Jul 06; 45(4). PMID: 24989938
Review.
Comparative economics of a 12-gene assay for predicting risk of recurrence in stage II colon cancer.
Steven R Alberts, Tiffany M Yu, +9 authors, John Hornberger.
Pharmacoeconomics, 2014 Aug 27; 32(12). PMID: 25154747    Free PMC article.
Updated guidelines for biomarker testing in colorectal carcinoma: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.
P García-Alfonso, J García-Foncillas, +9 authors, Spanish Society of Medical Oncology.
Clin Transl Oncol, 2014 Nov 07; 17(4). PMID: 25373533
Molecular markers predictive of chemotherapy response in colorectal cancer.
Stacey Shiovitz, William M Grady.
Curr Gastroenterol Rep, 2015 Feb 11; 17(2). PMID: 25663616    Free PMC article.
Review.
IGFBP-3 Gene Methylation in Primary Tumor Predicts Recurrence of Stage II Colorectal Cancers.
Tao Fu, Emmanouil P Pappou, +9 authors, Nita Ahuja.
Ann Surg, 2015 Mar 31; 263(2). PMID: 25822686    Free PMC article.
Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer.
Helgi Birgisson, Karolina Edlund, +8 authors, Magnus Sundström.
BMC Cancer, 2015 Apr 18; 15. PMID: 25884297    Free PMC article.
Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach.
Moisés Blanco-Calvo, Ángel Concha, +2 authors, Manuel Valladares-Ayerbes.
Int J Mol Sci, 2015 Jun 18; 16(6). PMID: 26084042    Free PMC article.
Review.
Surgical Options in the Treatment of Lower Gastrointestinal Tract Cancers.
Andrea S Porpiglia, Elin R Sigurdson.
Curr Treat Options Oncol, 2015 Jul 21; 16(9). PMID: 26188639
Review.
Validation of a quantitative 12-multigene expression assay (Oncotype DX(®) Colon Cancer Assay) in Korean patients with stage II colon cancer: implication of ethnic differences contributing to differences in gene expression.
Duck Hyoun Jeong, Woo Ram Kim, +3 authors, Nam Kyu Kim.
Onco Targets Ther, 2016 Jan 01; 8. PMID: 26719709    Free PMC article.
Precision Oncology Medicine: The Clinical Relevance of Patient-Specific Biomarkers Used to Optimize Cancer Treatment.
Keith T Schmidt, Cindy H Chau, Douglas K Price, William D Figg.
J Clin Pharmacol, 2016 May 21; 56(12). PMID: 27197880    Free PMC article.
Review.
A comparison of 12-gene colon cancer assay gene expression in African American and Caucasian patients with stage II colon cancer.
Rangaswamy Govindarajan, James Posey, +7 authors, Upender Manne.
BMC Cancer, 2016 Jun 19; 16. PMID: 27316467    Free PMC article.
Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer.
Jeanne Tie, Yuxuan Wang, +23 authors, Peter Gibbs.
Sci Transl Med, 2016 Jul 08; 8(346). PMID: 27384348    Free PMC article.
Highly Cited.
Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 (Alliance).
Donna Niedzwiecki, Wendy L Frankel, +16 authors, Federico Innocenti.
J Clin Oncol, 2016 Jul 20; 34(25). PMID: 27432924    Free PMC article.
Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer.
Maciej Bobowicz, Marcin Skrzypski, +10 authors, Jacek Jassem.
Clin Exp Metastasis, 2016 Aug 04; 33(8). PMID: 27485175    Free PMC article.
A comparative analysis and guidance for individualized chemotherapy of stage II and III colorectal cancer patients based on pathological markers.
Yang Han, Su Lu, +11 authors, Zhihai Peng.
Sci Rep, 2016 Nov 16; 6. PMID: 27845412    Free PMC article.
Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence.
Sjoerd H den Uil, Veerle M H Coupé, +13 authors, Remond J A Fijneman.
Br J Cancer, 2016 Nov 18; 115(12). PMID: 27855440    Free PMC article.
Molecular predictive markers in tumors of the gastrointestinal tract.
Eirini Papadopoulou, Vasiliki Metaxa-Mariatou, +8 authors, George Nasioulas.
World J Gastrointest Oncol, 2016 Nov 30; 8(11). PMID: 27895815    Free PMC article.
Review.
Role of circulating free DNA in colorectal cancer.
Alexios Matikas, Alexandra Voutsina, Maria Trypaki, Vassilis Georgoulias.
World J Gastrointest Oncol, 2016 Dec 31; 8(12). PMID: 28035251    Free PMC article.
Review.
Lymphovascular invasion is a high risk factor for stage I/II colorectal cancer: a systematic review and meta-analysis.
Hang Yuan, Quanjin Dong, +3 authors, Shiliang Tu.
Oncotarget, 2017 Apr 22; 8(28). PMID: 28430621    Free PMC article.
Systematic Review.
What We Know About Stage II and III Colon Cancer: It's Still Not Enough.
Alberto Puccini, Martin D Berger, Wu Zhang, Heinz-Josef Lenz.
Target Oncol, 2017 May 16; 12(3). PMID: 28504299    Free PMC article.
Review.
Differentially Expressed lncRNAs in Gastric Cancer Patients: A Potential Biomarker for Gastric Cancer Prognosis.
Xianglong Tian, Xiaoqiang Zhu, +5 authors, Jing-Yuan Fang.
J Cancer, 2017 Sep 14; 8(13). PMID: 28900495    Free PMC article.
Perioperative dynamics and significance of plasma-free amino acid profiles in colorectal cancer.
Kayoko Katayama, Akio Higuchi, +3 authors, Manabu Shiozawa.
BMC Surg, 2018 Feb 23; 18(1). PMID: 29466971    Free PMC article.
Significance and implications of FDA approval of pembrolizumab for biomarker-defined disease.
Michael M Boyiadzis, John M Kirkwood, +3 authors, James L Gulley.
J Immunother Cancer, 2018 May 15; 6(1). PMID: 29754585    Free PMC article.
Highly Cited. Review.
Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy.
W L Allen, P D Dunne, +28 authors, D B Longley.
JCO Precis Oncol, 2018 Aug 09; 2018. PMID: 30088816    Free PMC article.
Molecular characterization and biomarker identification in colorectal cancer: Toward realization of the precision medicine dream.
Gaurav Goel.
Cancer Manag Res, 2018 Dec 05; 10. PMID: 30510457    Free PMC article.
Review.
Making sense of adjuvant chemotherapy in colorectal cancer.
Gloria H J Chan, Cheng E Chee.
J Gastrointest Oncol, 2020 Jan 18; 10(6). PMID: 31949938    Free PMC article.
Review.
Multiple Level CT Radiomics Features Preoperatively Predict Lymph Node Metastasis in Esophageal Cancer: A Multicentre Retrospective Study.
Lei Wu, Xiaojun Yang, +7 authors, Changhong Liang.
Front Oncol, 2020 Feb 11; 9. PMID: 32039021    Free PMC article.
RNA-seq of newly diagnosed patients in the PADIMAC study leads to a bortezomib/lenalidomide decision signature.
Michael A Chapman, Jonathan Sive, +27 authors, Kwee Yong.
Blood, 2018 Sep 06; 132(20). PMID: 30181174    Free PMC article.
Sidedness Matters: Surrogate Biomarkers Prognosticate Colorectal Cancer upon Anatomic Location.
Irit Ben-Aharon, Tal Goshen-Lago, +13 authors, Baruch Brenner.
Oncologist, 2019 Feb 14; 24(8). PMID: 30755502    Free PMC article.
Development and validation of a lipogenic genes panel for diagnosis and recurrence of colorectal cancer.
Ehsan Gharib, Parinaz Nasrinasrabadi, Mohammad Reza Zali.
PLoS One, 2020 Mar 11; 15(3). PMID: 32155177    Free PMC article.
Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial.
Hideki Ueno, Megumi Ishiguro, +17 authors, SACURA Study Group.
J Clin Oncol, 2019 Jun 11; 37(22). PMID: 31180819    Free PMC article.
Circulating Tumor DNA as a Novel Biomarker Optimizing Chemotherapy for Colorectal Cancer.
Hiroki Osumi, Eiji Shinozaki, Kensei Yamaguchi.
Cancers (Basel), 2020 Jun 18; 12(6). PMID: 32545750    Free PMC article.
Review.
Prognostic and Predictive Value of a Long Non-coding RNA Signature in Glioma: A lncRNA Expression Analysis.
Yuan-Bo Pan, Yiming Zhu, +3 authors, Jianmin Zhang.
Front Oncol, 2020 Aug 15; 10. PMID: 32793467    Free PMC article.
Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions.
Sakti Chakrabarti, Carrie Y Peterson, Deepika Sriram, Amit Mahipal.
World J Gastrointest Oncol, 2020 Sep 04; 12(8). PMID: 32879661    Free PMC article.
Review.
Update of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology.
P García-Alfonso, R García-Carbonero, +9 authors, S Navarro.
Clin Transl Oncol, 2020 May 18; 22(11). PMID: 32418154    Free PMC article.
Adjuvant Chemotherapy for Stage III Colon Cancer.
Julien Taieb, Claire Gallois.
Cancers (Basel), 2020 Sep 24; 12(9). PMID: 32961795    Free PMC article.
Review.
Young-Onset Colon Cancer and Recurrence Risk by Gene Expression.
George J Chang, Y Nancy Y You, +5 authors, Howard S Hochster.
J Natl Cancer Inst, 2020 Feb 11; 112(11). PMID: 32040172    Free PMC article.
Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer: Prospective Validation in a Randomized Controlled Study (SACURA Trial).
Hideki Ueno, Megumi Ishiguro, +16 authors, SACURA Study Group.
Am J Surg Pathol, 2020 Sep 02; 44(12). PMID: 32868525    Free PMC article.
Ellagic acid ameliorates cisplatin toxicity in chemically induced colon carcinogenesis.
Yasmeen Goyal, Ashwani Koul, Pavitra Ranawat.
Mol Cell Biochem, 2018 Sep 29; 453(1-2). PMID: 30264291
Precision medicine for adjuvant chemotherapy of resected colorectal cancer.
Yuji Miyamoto, Yukiharu Hiyoshi, +2 authors, Hideo Baba.
Ann Gastroenterol Surg, 2020 Dec 16; 4(6). PMID: 33319153    Free PMC article.
Review.
An integrated multi-omics approach to identify regulatory mechanisms in cancer metastatic processes.
Saba Ghaffari, Casey Hanson, +3 authors, Saurabh Sinha.
Genome Biol, 2021 Jan 09; 22(1). PMID: 33413550    Free PMC article.
Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial).
Hideki Ueno, Megumi Ishiguro, +16 authors, Kenichi Sugihara.
Br J Cancer, 2021 Jan 09;. PMID: 33414540
Machine learning identifies two autophagy-related genes as markers of recurrence in colorectal cancer.
Jianping Wu, Sulai Liu, +2 authors, Yaoping Tang.
J Int Med Res, 2020 Oct 21; 48(10). PMID: 33076720    Free PMC article.