Review
. 2013 Apr; 153(1):38-55.
doi: 10.1016/j.cell.2013.03.008.

Interplay between the cancer genome and epigenome

Hui Shen 1 Peter W Laird  
Affiliations
  • PMID: 23540689
  •     198 References
  •     338 citations

Abstract

Cancer arises as a consequence of cumulative disruptions to cellular growth control with Darwinian selection for those heritable changes that provide the greatest clonal advantage. These traits can be acquired and stably maintained by either genetic or epigenetic means. Here, we explore the ways in which alterations in the genome and epigenome influence each other and cooperate to promote oncogenic transformation. Disruption of epigenomic control is pervasive in malignancy and can be classified as an enabling characteristic of cancer cells, akin to genome instability and mutation.

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Cyril Quivoron, Lucile Couronné, +20 authors, Olivier A Bernard.
Cancer Cell, 2011 Jul 05; 20(1). PMID: 21723201
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DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response.
Jayne E P Loughery, Philip D Dunne, +3 authors, Colum P Walsh.
Hum Mol Genet, 2011 Jun 04; 20(16). PMID: 21636528
Cancer biology and NuRD: a multifaceted chromatin remodelling complex.
Anne Y Lai, Paul A Wade.
Nat Rev Cancer, 2011 Jul 08; 11(8). PMID: 21734722    Free PMC article.
Highly Cited. Review.
Altered telomeres in tumors with ATRX and DAXX mutations.
Christopher M Heaphy, Roeland F de Wilde, +22 authors, Alan K Meeker.
Science, 2011 Jul 02; 333(6041). PMID: 21719641    Free PMC article.
Highly Cited.
Increased methylation variation in epigenetic domains across cancer types.
Kasper Daniel Hansen, Winston Timp, +11 authors, Andrew P Feinberg.
Nat Genet, 2011 Jun 28; 43(8). PMID: 21706001    Free PMC article.
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DNA secondary structures and epigenetic determinants of cancer genome evolution.
Subhajyoti De, Franziska Michor.
Nat Struct Mol Biol, 2011 Jul 05; 18(8). PMID: 21725294    Free PMC article.
Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR.
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Cancer Cell, 2011 Aug 16; 20(2). PMID: 21840485
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.
Ryan D Morin, Maria Mendez-Lago, +47 authors, Marco A Marra.
Nature, 2011 Jul 29; 476(7360). PMID: 21796119    Free PMC article.
Highly Cited.
Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation.
Jason Gertz, Katherine E Varley, +6 authors, Richard M Myers.
PLoS Genet, 2011 Aug 20; 7(8). PMID: 21852959    Free PMC article.
Highly Cited.
The mutational landscape of head and neck squamous cell carcinoma.
Nicolas Stransky, Ann Marie Egloff, +36 authors, Jennifer R Grandis.
Science, 2011 Jul 30; 333(6046). PMID: 21798893    Free PMC article.
Highly Cited.
Analysis of the coding genome of diffuse large B-cell lymphoma.
Laura Pasqualucci, Vladimir Trifonov, +14 authors, Riccardo Dalla-Favera.
Nat Genet, 2011 Aug 02; 43(9). PMID: 21804550    Free PMC article.
Highly Cited.
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.
Yaoting Gui, Guangwu Guo, +50 authors, Zhiming Cai.
Nat Genet, 2011 Aug 09; 43(9). PMID: 21822268    Free PMC article.
Highly Cited.
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
Shinsuke Ito, Li Shen, +5 authors, Yi Zhang.
Science, 2011 Jul 23; 333(6047). PMID: 21778364    Free PMC article.
Highly Cited.
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.
Minjia Tan, Hao Luo, +15 authors, Yingming Zhao.
Cell, 2011 Sep 20; 146(6). PMID: 21925322    Free PMC article.
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A decade of exploring the cancer epigenome - biological and translational implications.
Stephen B Baylin, Peter A Jones.
Nat Rev Cancer, 2011 Sep 24; 11(10). PMID: 21941284    Free PMC article.
Highly Cited. Review.
Germline BAP1 mutations predispose to malignant mesothelioma.
Joseph R Testa, Mitchell Cheung, +16 authors, Michele Carbone.
Nat Genet, 2011 Aug 30; 43(10). PMID: 21874000    Free PMC article.
Highly Cited.
Germline mutations in BAP1 predispose to melanocytic tumors.
Thomas Wiesner, Anna C Obenauf, +21 authors, Michael R Speicher.
Nat Genet, 2011 Aug 30; 43(10). PMID: 21874003    Free PMC article.
Highly Cited.
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Alan Hodgkinson, Adam Eyre-Walker.
Nat Rev Genet, 2011 Oct 05; 12(11). PMID: 21969038
Highly Cited. Review.
Identification of genetic elements that autonomously determine DNA methylation states.
Florian Lienert, Christiane Wirbelauer, +3 authors, Dirk Schübeler.
Nat Genet, 2011 Oct 04; 43(11). PMID: 21964573
Highly Cited.
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis.
Jiaying Tan, Morgan Jones, +4 authors, Jay L Hess.
Cancer Cell, 2011 Nov 19; 20(5). PMID: 22094252    Free PMC article.
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
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Cell, 1999 Nov 11; 99(3). PMID: 10555141
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Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression.
J R Graff, E Gabrielson, +2 authors, J G Herman.
J Biol Chem, 2000 Jan 25; 275(4). PMID: 10644736
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Mutations truncating the EP300 acetylase in human cancers.
S A Gayther, S J Batley, +11 authors, C Caldas.
Nat Genet, 2000 Mar 04; 24(3). PMID: 10700188
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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
M Esteller, M Toyota, +7 authors, J G Herman.
Cancer Res, 2000 May 16; 60(9). PMID: 10811111
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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
M Esteller, J Garcia-Foncillas, +5 authors, J G Herman.
N Engl J Med, 2000 Nov 09; 343(19). PMID: 11070098
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Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.
M Esteller, R A Risques, +5 authors, J G Herman.
Cancer Res, 2001 Jun 19; 61(12). PMID: 11406538
Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.
Galina N Filippova, Chen-Feng Qi, +19 authors, Victor V Lobanenkov.
Cancer Res, 2002 Jan 10; 62(1). PMID: 11782357
The fundamental role of epigenetic events in cancer.
Peter A Jones, Stephen B Baylin.
Nat Rev Genet, 2002 Jun 04; 3(6). PMID: 12042769
Highly Cited. Review.
Chromosomal instability and tumors promoted by DNA hypomethylation.
Amir Eden, François Gaudet, Alpana Waghmare, Rudolf Jaenisch.
Science, 2003 Apr 19; 300(5618). PMID: 12702868
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Deficiency of Mbd2 suppresses intestinal tumorigenesis.
Owen J Sansom, Jennifer Berger, +3 authors, Alan R Clarke.
Nat Genet, 2003 May 06; 34(2). PMID: 12730693
Genetics supersedes epigenetics in colon cancer phenotype.
Kentaro Yamashita, Tomoko Dai, +2 authors, Manuel Perucho.
Cancer Cell, 2003 Sep 06; 4(2). PMID: 12957287
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Adrian P Bracken, Diego Pasini, +3 authors, Kristian Helin.
EMBO J, 2003 Oct 09; 22(20). PMID: 14532106    Free PMC article.
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Xiang-Jiao Yang.
Nucleic Acids Res, 2004 Feb 13; 32(3). PMID: 14960713    Free PMC article.
Highly Cited. Review.
Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.
Ge Guo, Wei Wang, Allan Bradley.
Nature, 2004 Jun 25; 429(6994). PMID: 15215866
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells.
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M Ehrlich, R Y Wang.
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M Ehrlich, M A Gama-Sosa, +4 authors, C Gehrke.
Nucleic Acids Res, 1982 Apr 24; 10(8). PMID: 7079182    Free PMC article.
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R Y Wang, K C Kuo, +2 authors, M Ehrlich.
Biochim Biophys Acta, 1982 Jun 30; 697(3). PMID: 7104364
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Biochem Biophys Res Commun, 1982 Jul 16; 107(1). PMID: 6289818
Hypomethylation distinguishes genes of some human cancers from their normal counterparts.
A P Feinberg, B Vogelstein.
Nature, 1983 Jan 06; 301(5895). PMID: 6185846
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A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA.
A Bird, M Taggart, +2 authors, D Macleod.
Cell, 1985 Jan 01; 40(1). PMID: 2981636
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DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.
S B Baylin, J W Höppener, +3 authors, B D Nelkin.
Cancer Res, 1986 Jun 01; 46(6). PMID: 3009002
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P W Laird, L Jackson-Grusby, +5 authors, R Jaenisch.
Cell, 1995 Apr 21; 81(2). PMID: 7537636
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A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers.
G N Filippova, A Lindblom, +5 authors, V V Lobanenkov.
Genes Chromosomes Cancer, 1998 May 20; 22(1). PMID: 9591631
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Proc Natl Acad Sci U S A, 1998 Jun 17; 95(12). PMID: 9618505    Free PMC article.
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Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.
I Versteege, N Sévenet, +5 authors, O Delattre.
Nature, 1998 Jul 22; 394(6689). PMID: 9671307
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Cancer epigenetics comes of age.
P A Jones, P W Laird.
Nat Genet, 1999 Feb 13; 21(2). PMID: 9988266
Highly Cited. Review.
MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers.
S B Simpkins, T Bocker, +6 authors, P J Goodfellow.
Hum Mol Genet, 1999 Mar 11; 8(4). PMID: 10072435
CpG island methylator phenotype in colorectal cancer.
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Proc Natl Acad Sci U S A, 1999 Jul 21; 96(15). PMID: 10411935    Free PMC article.
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Rohinton T Kamakaka, Sue Biggins.
Genes Dev, 2005 Feb 03; 19(3). PMID: 15687254
Highly Cited. Review.
MGMT gene silencing and benefit from temozolomide in glioblastoma.
Monika E Hegi, Annie-Claire Diserens, +13 authors, Roger Stupp.
N Engl J Med, 2005 Mar 11; 352(10). PMID: 15758010
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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
Mario F Fraga, Esteban Ballestar, +20 authors, Manel Esteller.
Nat Genet, 2005 Mar 15; 37(4). PMID: 15765097
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Association of chromosome arm 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.
Stephanie K Mummert, Victor A Lobanenkov, Andrew P Feinberg.
Genes Chromosomes Cancer, 2005 Mar 12; 43(2). PMID: 15761865
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Oliver Mortusewicz, Lothar Schermelleh, +2 authors, Heinrich Leonhardt.
Proc Natl Acad Sci U S A, 2005 Jun 16; 102(25). PMID: 15956212    Free PMC article.
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Global histone modification patterns predict risk of prostate cancer recurrence.
David B Seligson, Steve Horvath, +4 authors, Siavash K Kurdistani.
Nature, 2005 Jul 01; 435(7046). PMID: 15988529
Highly Cited.
Kaiso-deficient mice show resistance to intestinal cancer.
Anna Prokhortchouk, Owen Sansom, +12 authors, Adrian Bird.
Mol Cell Biol, 2005 Dec 16; 26(1). PMID: 16354691    Free PMC article.
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.
Saverio Minucci, Pier Giuseppe Pelicci.
Nat Rev Cancer, 2006 Jan 07; 6(1). PMID: 16397526
Highly Cited. Review.
DNA methyltransferases control telomere length and telomere recombination in mammalian cells.
Susana Gonzalo, Isabel Jaco, +4 authors, María A Blasco.
Nat Cell Biol, 2006 Mar 28; 8(4). PMID: 16565708
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Bradley E Bernstein, Tarjei S Mikkelsen, +12 authors, Eric S Lander.
Cell, 2006 Apr 25; 125(2). PMID: 16630819
Highly Cited.
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
Daniel J Weisenberger, Kimberly D Siegmund, +18 authors, Peter W Laird.
Nat Genet, 2006 Jun 29; 38(7). PMID: 16804544
Highly Cited.
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Paul A C Cloos, Jesper Christensen, +5 authors, Kristian Helin.
Nature, 2006 May 30; 442(7100). PMID: 16732293
Highly Cited.
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.
Yeshayahu Schlesinger, Ravid Straussman, +10 authors, Howard Cedar.
Nat Genet, 2007 Jan 04; 39(2). PMID: 17200670
Highly Cited.
Epigenetic stem cell signature in cancer.
Martin Widschwendter, Heidi Fiegl, +8 authors, Peter W Laird.
Nat Genet, 2007 Jan 04; 39(2). PMID: 17200673
Highly Cited.
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Joyce E Ohm, Kelly M McGarvey, +14 authors, Stephen B Baylin.
Nat Genet, 2007 Jan 11; 39(2). PMID: 17211412    Free PMC article.
Highly Cited.
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome.
Tae Hoon Kim, Ziedulla K Abdullaev, +6 authors, Bing Ren.
Cell, 2007 Mar 27; 128(6). PMID: 17382889    Free PMC article.
Highly Cited.
Hyperconserved CpG domains underlie Polycomb-binding sites.
Amos Tanay, Anne H O'Donnell, Marc Damelin, Timothy H Bestor.
Proc Natl Acad Sci U S A, 2007 Mar 23; 104(13). PMID: 17376869    Free PMC article.
Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis.
Susan J Clark.
Hum Mol Genet, 2007 Sep 26; 16 Spec No 1. PMID: 17613553
Review.
Acute promyelocytic leukemia: from highly fatal to highly curable.
Zhen-Yi Wang, Zhu Chen.
Blood, 2008 Feb 27; 111(5). PMID: 18299451
Highly Cited. Review.
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
C A French, C L Ramirez, +9 authors, J C Aster.
Oncogene, 2007 Oct 16; 27(15). PMID: 17934517
Highly Cited.
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.
Vincent Dion, Yunfu Lin, +2 authors, John H Wilson.
Hum Mol Genet, 2008 Feb 07; 17(9). PMID: 18252747    Free PMC article.
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
Yutaka Kondo, Lanlan Shen, +11 authors, Jean-Pierre J Issa.
Nat Genet, 2008 May 20; 40(6). PMID: 18488029
Highly Cited.
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.
Fabio Mohn, Michael Weber, +5 authors, Dirk Schübeler.
Mol Cell, 2008 Jun 03; 30(6). PMID: 18514006
Highly Cited.
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.
Kristi Kerkel, Alexandra Spadola, +10 authors, Benjamin Tycko.
Nat Genet, 2008 Jun 24; 40(7). PMID: 18568024
Highly Cited.
Menin critically links MLL proteins with LEDGF on cancer-associated target genes.
Akihiko Yokoyama, Michael L Cleary.
Cancer Cell, 2008 Jul 05; 14(1). PMID: 18598942    Free PMC article.
Highly Cited.
Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.
Einav Nili Gal-Yam, Gerda Egger, +7 authors, Amos Tanay.
Proc Natl Acad Sci U S A, 2008 Aug 30; 105(35). PMID: 18753622    Free PMC article.
Highly Cited.
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.
Manching Ku, Richard P Koche, +14 authors, Bradley E Bernstein.
PLoS Genet, 2008 Nov 01; 4(10). PMID: 18974828    Free PMC article.
Highly Cited.
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.
Sooryanarayana Varambally, Qi Cao, +17 authors, Arul M Chinnaiyan.
Science, 2008 Nov 15; 322(5908). PMID: 19008416    Free PMC article.
Highly Cited.
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1.
Marjolijn J L Ligtenberg, Roland P Kuiper, +15 authors, Nicoline Hoogerbrugge.
Nat Genet, 2008 Dec 23; 41(1). PMID: 19098912
Highly Cited.
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.
Rafael A Irizarry, Christine Ladd-Acosta, +11 authors, Andrew P Feinberg.
Nat Genet, 2009 Jan 20; 41(2). PMID: 19151715    Free PMC article.
Highly Cited.
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
Gijs van Haaften, Gillian L Dalgliesh, +59 authors, P Andrew Futreal.
Nat Genet, 2009 Mar 31; 41(5). PMID: 19330029    Free PMC article.
Highly Cited.
Acquired mutations in TET2 are common in myelodysplastic syndromes.
Saskia M C Langemeijer, Roland P Kuiper, +15 authors, Joop H Jansen.
Nat Genet, 2009 Jun 02; 41(7). PMID: 19483684
Highly Cited.
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.
Omar Abdel-Wahab, Ann Mullally, +21 authors, Ross L Levine.
Blood, 2009 May 08; 114(1). PMID: 19420352    Free PMC article.
Highly Cited.
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions.
Chunyuan Jin, Chongzhi Zang, +4 authors, Gary Felsenfeld.
Nat Genet, 2009 Jul 28; 41(8). PMID: 19633671    Free PMC article.
Highly Cited.
Rethinking how DNA methylation patterns are maintained.
Peter A Jones, Gangning Liang.
Nat Rev Genet, 2009 Oct 01; 10(11). PMID: 19789556    Free PMC article.
Highly Cited. Review.
Epigenetic therapy in lung cancer.
Stephen V Liu, Muller Fabbri, Barbara J Gitlitz, Ite A Laird-Offringa.
Front Oncol, 2013 Jun 12; 3. PMID: 23755372    Free PMC article.
Cancer hallmarks sustained by ectopic activations of placenta/male germline genes.
Sophie Rousseaux, Jin Wang, Saadi Khochbin.
Cell Cycle, 2013 Jul 17; 12(15). PMID: 23856584    Free PMC article.
Alterations of DNA methylome in human bladder cancer.
Ahmad Besaratinia, Myles Cockburn, Stella Tommasi.
Epigenetics, 2013 Aug 27; 8(10). PMID: 23975266    Free PMC article.
Review.
BLUEPRINT: mapping human blood cell epigenomes.
Joost H A Martens, Hendrik G Stunnenberg.
Haematologica, 2013 Oct 05; 98(10). PMID: 24091925    Free PMC article.
Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer.
Christoph Plass, Stefan M Pfister, +3 authors, Peter Lichter.
Nat Rev Genet, 2013 Oct 10; 14(11). PMID: 24105274
Highly Cited. Review.
Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.
Xiaofeng Wang, Jeffrey R Haswell, Charles W M Roberts.
Clin Cancer Res, 2013 Oct 15; 20(1). PMID: 24122795    Free PMC article.
HERV-K and LINE-1 DNA Methylation and Reexpression in Urothelial Carcinoma.
Ulrike Kreimer, Wolfgang A Schulz, +2 authors, Wolfgang Goering.
Front Oncol, 2013 Oct 18; 3. PMID: 24133654    Free PMC article.
Oncogenic features of PHF8 histone demethylase in esophageal squamous cell carcinoma.
Xiujing Sun, Jihui Julia Qiu, +6 authors, Shuo Dong.
PLoS One, 2013 Oct 23; 8(10). PMID: 24146981    Free PMC article.
Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence.
Jacob A Theruvathu, Y Whitney Yin, B Montgomery Pettitt, Lawrence C Sowers.
Biochemistry, 2013 Oct 24; 52(47). PMID: 24147911    Free PMC article.
The role of cell density and intratumoral heterogeneity in multidrug resistance.
Orit Lavi, James M Greene, Doron Levy, Michael M Gottesman.
Cancer Res, 2013 Oct 29; 73(24). PMID: 24163380    Free PMC article.
Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.
Allison Jones, Andrew E Teschendorff, +19 authors, Martin Widschwendter.
PLoS Med, 2013 Nov 23; 10(11). PMID: 24265601    Free PMC article.
Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia.
E Jost, Q Lin, +9 authors, W Wagner.
Leukemia, 2013 Nov 28; 28(6). PMID: 24280869    Free PMC article.
Pathway analyses and understanding disease associations.
Yu Liu, Mark R Chance.
Curr Genet Med Rep, 2013 Dec 10; 1(4). PMID: 24319650    Free PMC article.
Targeting Histone Deacetylases in Diseases: Where Are We?
Rosaria Benedetti, Mariarosaria Conte, Lucia Altucci.
Antioxid Redox Signal, 2014 Jan 03; 23(1). PMID: 24382114    Free PMC article.
Review.
At the tipping point for epigenetic therapies in cancer.
Peter A Jones.
J Clin Invest, 2014 Jan 03; 124(1). PMID: 24382384    Free PMC article.
Characterizing DNA methylation alterations from The Cancer Genome Atlas.
Daniel J Weisenberger.
J Clin Invest, 2014 Jan 03; 124(1). PMID: 24382385    Free PMC article.
Highly Cited. Review.
Cancer epigenetics drug discovery and development: the challenge of hitting the mark.
Robert M Campbell, Peter J Tummino.
J Clin Invest, 2014 Jan 03; 124(1). PMID: 24382391    Free PMC article.
Review.
Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant and malignant pleural effusions.
Dimo Dietrich, Maria Jung, +7 authors, Glen Kristiansen.
PLoS One, 2014 Jan 05; 8(12). PMID: 24386354    Free PMC article.
Clinicopathological and prognostic significance of EZH2 expression in upper urinary tract carcinoma.
Akimasa Hayashi, Teppei Morikawa, +4 authors, Masashi Fukayama.
Virchows Arch, 2014 Jan 22; 464(4). PMID: 24446035
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.
Dominik Sturm, Sebastian Bender, +12 authors, Stefan M Pfister.
Nat Rev Cancer, 2014 Jan 25; 14(2). PMID: 24457416    Free PMC article.
Highly Cited. Review.
Receptor-Independent Ectopic Activity of Prolactin Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies.
Aurore Le Bescont, Anne-Laure Vitte, +11 authors, Saadi Khochbin.
Antioxid Redox Signal, 2014 Feb 12; 23(1). PMID: 24512221    Free PMC article.
DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer.
Shama Prasada Kabekkodu, Samatha Bhat, +7 authors, Kapaettu Satyamoorthy.
J Biol Chem, 2014 Feb 27; 289(15). PMID: 24570007    Free PMC article.
Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue.
Jianxin Shi, Crystal N Marconett, +29 authors, Maria Teresa Landi.
Nat Commun, 2014 Feb 28; 5. PMID: 24572595    Free PMC article.
Highly Cited.
Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI.
John R Horton, Rebecca L Nugent, +9 authors, Xiaodong Cheng.
Sci Rep, 2014 Mar 08; 4. PMID: 24604015    Free PMC article.
Metastatic stem cells: sources, niches, and vital pathways.
Thordur Oskarsson, Eduard Batlle, Joan Massagué.
Cell Stem Cell, 2014 Mar 13; 14(3). PMID: 24607405    Free PMC article.
Highly Cited. Review.
Concurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior.
Akimasa Hayashi, Naoko Yamauchi, +9 authors, Masashi Fukayama.
PLoS One, 2014 Mar 13; 9(3). PMID: 24614346    Free PMC article.
Identification of genes with consistent methylation levels across different human tissues.
Tzu-Pin Lu, Kevin T Chen, +4 authors, Eric Y Chuang.
Sci Rep, 2014 Mar 13; 4. PMID: 24619003    Free PMC article.
Individualized medicine from prewomb to tomb.
Eric J Topol.
Cell, 2014 Apr 01; 157(1). PMID: 24679539    Free PMC article.
Highly Cited. Review.
Reprogramming cancer cells to pluripotency: an experimental tool for exploring cancer epigenetics.
Stefan Stricker, Steven Pollard.
Epigenetics, 2014 Apr 02; 9(6). PMID: 24686321    Free PMC article.
Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells.
W Fiskus, S Sharma, +6 authors, K N Bhalla.
Leukemia, 2014 Apr 05; 28(11). PMID: 24699304    Free PMC article.
Highly Cited.
Performance evaluation of kits for bisulfite-conversion of DNA from tissues, cell lines, FFPE tissues, aspirates, lavages, effusions, plasma, serum, and urine.
Emily Eva Holmes, Maria Jung, +8 authors, Dimo Dietrich.
PLoS One, 2014 Apr 05; 9(4). PMID: 24699908    Free PMC article.
Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression.
Madalena Barroso, Cristina Florindo, +11 authors, Diane E Handy.
J Biol Chem, 2014 Apr 11; 289(22). PMID: 24719327    Free PMC article.
Loss of the polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors.
Maria A Hahn, Arthur X Li, +4 authors, Gerd P Pfeifer.
Cancer Res, 2014 May 03; 74(13). PMID: 24786786    Free PMC article.
Histone target selection within chromatin: an exemplary case of teamwork.
Marie-Eve Lalonde, Xue Cheng, Jacques Côté.
Genes Dev, 2014 May 17; 28(10). PMID: 24831698    Free PMC article.
Review.
MethylSig: a whole genome DNA methylation analysis pipeline.
Yongseok Park, Maria E Figueroa, Laura S Rozek, Maureen A Sartor.
Bioinformatics, 2014 May 20; 30(17). PMID: 24836530    Free PMC article.
Highly Cited.
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.
Volker Hovestadt, David T W Jones, +42 authors, Peter Lichter.
Nature, 2014 May 23; 510(7506). PMID: 24847876
Highly Cited.
Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions.
Renske D M Steenbergen, Peter J F Snijders, Daniëlle A M Heideman, Chris J L M Meijer.
Nat Rev Cancer, 2014 May 24; 14(6). PMID: 24854082
Highly Cited. Review.
Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds.
Emilie F Rissman, Mazhar Adli.
Endocrinology, 2014 Jun 03; 155(8). PMID: 24885575    Free PMC article.
Review.
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.
Sakari Vanharanta, Christina B Marney, +5 authors, Joan Massagué.
Elife, 2014 Jun 06; 3. PMID: 24898756    Free PMC article.
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.
Hariharan Easwaran, Hsing-Chen Tsai, Stephen B Baylin.
Mol Cell, 2014 Jun 07; 54(5). PMID: 24905005    Free PMC article.
Highly Cited. Review.
The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique.
Sebastian Marwitz, Julia Kolarova, +9 authors, Ole Ammerpohl.
Lab Invest, 2014 Jun 17; 94(8). PMID: 24933424
Epigenetic regulation by chromatin activation mark H3K4me3 in primate progenitor cells within adult neurogenic niche.
Richard S Sandstrom, Michael R Foret, +7 authors, Chin-Hsing Annie Lin.
Sci Rep, 2014 Jun 21; 4. PMID: 24947819    Free PMC article.
DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability.
Yuta Muto, Takafumi Maeda, +10 authors, Toshiki Rikiyama.
BMC Cancer, 2014 Jun 27; 14. PMID: 24964857    Free PMC article.
High throughput screening identifies modulators of histone deacetylase inhibitors.
Ann-Christin Gaupel, Thomas Begley, Martin Tenniswood.
BMC Genomics, 2014 Jun 28; 15. PMID: 24968945    Free PMC article.
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
Joyce V Lee, Alessandro Carrer, +19 authors, Kathryn E Wellen.
Cell Metab, 2014 Jul 08; 20(2). PMID: 24998913    Free PMC article.
Highly Cited.
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.
Zhaoming Wang, Bin Zhu, +348 authors, Laufey T Amundadottir.
Hum Mol Genet, 2014 Jul 17; 23(24). PMID: 25027329    Free PMC article.
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
Paul A Northcott, Catherine Lee, +76 authors, Stefan M Pfister.
Nature, 2014 Jul 22; 511(7510). PMID: 25043047    Free PMC article.
Highly Cited.
Evolving understanding of the CLL genome.
Michaela Gruber, Catherine J Wu.
Semin Hematol, 2014 Jul 23; 51(3). PMID: 25048782    Free PMC article.
Review.
Epigenetics of hematopoietic stem cell aging and disease.
Motohiko Oshima, Atsushi Iwama.
Int J Hematol, 2014 Aug 02; 100(4). PMID: 25082353
Review.
Genetic landscape of esophageal squamous cell carcinoma.
Yi-Bo Gao, Zhao-Li Chen, +30 authors, Jie He.
Nat Genet, 2014 Aug 26; 46(10). PMID: 25151357
Highly Cited.
The somatic genomic landscape of chromophobe renal cell carcinoma.
Caleb F Davis, Christopher J Ricketts, +44 authors, Chad J Creighton.
Cancer Cell, 2014 Aug 27; 26(3). PMID: 25155756    Free PMC article.
Highly Cited.
MLL5 expression as a biomarker for DNA hypermethylation and sensitivity to epigenetic therapy.
Thomas A Milne.
Haematologica, 2014 Sep 02; 99(9). PMID: 25176980    Free PMC article.
Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors.
Winston Timp, Hector Corrada Bravo, +5 authors, Rafael A Irizarry.
Genome Med, 2014 Sep 06; 6(8). PMID: 25191524    Free PMC article.
Highly Cited.
Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.
Jochen Gaedcke, Andreas Leha, +12 authors, Michael Ghadimi.
Oncotarget, 2014 Sep 28; 5(18). PMID: 25261372    Free PMC article.
Translational research in oncology--10 years of progress and future prospects.
James H Doroshow, Shivaani Kummar.
Nat Rev Clin Oncol, 2014 Oct 08; 11(11). PMID: 25286976
Review.
Impact of soy isoflavones on the epigenome in cancer prevention.
Maria Pudenz, Kevin Roth, Clarissa Gerhauser.
Nutrients, 2014 Oct 17; 6(10). PMID: 25322458    Free PMC article.
Review.
Deciphering cancer heterogeneity: the biological space.
Stephanie Roessler, Anuradha Budhu, Xin W Wang.
Front Cell Dev Biol, 2014 Nov 05; 2. PMID: 25364720    Free PMC article.
Heterogeneity of DNA methylation in multifocal prostate cancer.
Inga Serenaite, Kristina Daniunaite, +4 authors, Sonata Jarmalaite.
Virchows Arch, 2014 Nov 06; 466(1). PMID: 25369892
Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.
Subarna Sinha, Daniel Thomas, +8 authors, Ravindra Majeti.
Blood, 2014 Nov 16; 125(2). PMID: 25398938    Free PMC article.
Metabolism and epigenetics: a link cancer cells exploit.
Alessandro Carrer, Kathryn E Wellen.
Curr Opin Biotechnol, 2014 Dec 03; 34. PMID: 25461508    Free PMC article.
Review.
Pan-cancer patterns of DNA methylation.
Tania Witte, Christoph Plass, Clarissa Gerhauser.
Genome Med, 2014 Dec 05; 6(8). PMID: 25473433    Free PMC article.
Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer.
Kotaro Kiga, Yoko Fukuda-Yuzawa, +3 authors, Taro Fukao.
RNA Biol, 2014 Dec 09; 11(11). PMID: 25483038    Free PMC article.
A global assessment of cancer genomic alterations in epigenetic mechanisms.
Muhammad A Shah, Emily L Denton, +2 authors, Matthieu Schapira.
Epigenetics Chromatin, 2014 Dec 09; 7(1). PMID: 25484917    Free PMC article.
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.
Lanxin Liu, Sarah Kimball, +2 authors, Zeng-Quan Yang.
Oncotarget, 2014 Dec 30; 6(4). PMID: 25537518    Free PMC article.
Epigenetic States of nephron progenitors and epithelial differentiation.
Mazhar Adli, Mahmut Parlak, Yuwen Li, Samir S El-Dahr.
J Cell Biochem, 2015 Jan 07; 116(6). PMID: 25560433    Free PMC article.
Review.
Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history.
Daniel J Weisenberger, A Joan Levine, +23 authors, Colon Cancer Family Registry.
Cancer Epidemiol Biomarkers Prev, 2015 Jan 15; 24(3). PMID: 25587051    Free PMC article.
Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups.
Catherine E Bond, Mark L Bettington, +3 authors, Vicki L J Whitehall.
BMC Cancer, 2015 Jan 24; 15. PMID: 25613750    Free PMC article.
Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans.
Sergio Alonso, Yuichi Dai, +9 authors, Manuel Perucho.
Oncotarget, 2015 Feb 02; 6(5). PMID: 25638164    Free PMC article.
The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer.
Ronan Chaligné, Tatiana Popova, +10 authors, Edith Heard.
Genome Res, 2015 Feb 06; 25(4). PMID: 25653311    Free PMC article.
MYC is a critical target of FBXW7.
Mai Sato, Ruth Rodriguez-Barrueco, +3 authors, Jean Gautier.
Oncotarget, 2015 Feb 12; 6(5). PMID: 25669969    Free PMC article.
Endoplasmic reticulum stress, genome damage, and cancer.
Naomi Dicks, Karina Gutierrez, +2 authors, Luis B Agellon.
Front Oncol, 2015 Feb 19; 5. PMID: 25692096    Free PMC article.
Review.
Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk.
Akram Ghantous, Hector Hernandez-Vargas, +2 authors, Zdenko Herceg.
Mutagenesis, 2015 Mar 01; 30(6). PMID: 25724893    Free PMC article.
Review.
The epigenetic basis of diffuse large B-cell lymphoma.
Yanwen Jiang, Ari Melnick.
Semin Hematol, 2015 Mar 26; 52(2). PMID: 25805588    Free PMC article.
Review.
Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae.
Kim Sneppen, Ian B Dodd.
Epigenetics, 2015 Apr 02; 10(4). PMID: 25830651    Free PMC article.
Cell surface-based sensing with metallic nanoparticles.
Ziwen Jiang, Ngoc D B Le, Akash Gupta, Vincent M Rotello.
Chem Soc Rev, 2015 Apr 09; 44(13). PMID: 25853985    Free PMC article.
Review.
Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies.
Kimryn W Rathmell, Fengju Chen, Chad J Creighton.
Oncoscience, 2015 Apr 11; 2(2). PMID: 25859550    Free PMC article.
Review.
Pan-cancer stratification of solid human epithelial tumors and cancer cell lines reveals commonalities and tissue-specific features of the CpG island methylator phenotype.
Francisco Sánchez-Vega, Valer Gotea, Gennady Margolin, Laura Elnitski.
Epigenetics Chromatin, 2015 May 12; 8. PMID: 25960768    Free PMC article.
Revealing the Molecular Portrait of Triple Negative Breast Tumors in an Understudied Population through Omics Analysis of Formalin-Fixed and Paraffin-Embedded Tissues.
Felipe Vaca-Paniagua, Rosa María Alvarez-Gomez, +17 authors, Magali Olivier.
PLoS One, 2015 May 12; 10(5). PMID: 25961742    Free PMC article.
Hyperemesis gravidarum and risk of cancer in offspring, a Scandinavian registry-based nested case-control study.
Kathrine F Vandraas, Åse V Vikanes, +7 authors, Tom Grotmol.
BMC Cancer, 2015 May 13; 15. PMID: 25963309    Free PMC article.
Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia.
Romain Guièze, Catherine J Wu.
Blood, 2015 Jun 13; 126(4). PMID: 26065654    Free PMC article.
Review.
JNK-dependent gene regulatory circuitry governs mesenchymal fate.
Sanjeeb Kumar Sahu, Angela Garding, +9 authors, Vijay K Tiwari.
EMBO J, 2015 Jul 15; 34(16). PMID: 26157010    Free PMC article.
An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer.
Zhen Yang, Allison Jones, Martin Widschwendter, Andrew E Teschendorff.
Genome Biol, 2015 Jul 15; 16. PMID: 26169266    Free PMC article.
Systematically Prioritizing Functional Differentially Methylated Regions (fDMRs) by Integrating Multi-omics Data in Colorectal Cancer.
Huihui Fan, Hongying Zhao, +7 authors, Xia Li.
Sci Rep, 2015 Aug 05; 5. PMID: 26239918    Free PMC article.
Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib.
Baohua Sun, Bhavin Shah, +12 authors, Kapil N Bhalla.
Blood, 2015 Aug 09; 126(13). PMID: 26254443    Free PMC article.
Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes.
Jessamy C Tiffen, Dilini Gunatilake, +13 authors, Peter Hersey.
Oncotarget, 2015 Aug 26; 6(29). PMID: 26304929    Free PMC article.
Early Prediction of Cancer Progression by Depth-Resolved Nanoscale Mapping of Nuclear Architecture from Unstained Tissue Specimens.
Shikhar Uttam, Hoa V Pham, +5 authors, Yang Liu.
Cancer Res, 2015 Sep 19; 75(22). PMID: 26383164    Free PMC article.
Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid.
Xavier Castells, Sandra Karanović, +21 authors, Jiri Zavadil.
Cancer Epidemiol Biomarkers Prev, 2015 Sep 19; 24(12). PMID: 26383547    Free PMC article.
Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment.
Xiao-xiao Sun, Qiang Yu.
Acta Pharmacol Sin, 2015 Sep 22; 36(10). PMID: 26388155    Free PMC article.
Review.
Intron retention is a widespread mechanism of tumor-suppressor inactivation.
Hyunchul Jung, Donghoon Lee, +6 authors, Eunjung Lee.
Nat Genet, 2015 Oct 06; 47(11). PMID: 26437032
Highly Cited.
EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.
Feng Liu, Gary C Hon, +21 authors, Paul S Mischel.
Mol Cell, 2015 Oct 13; 60(2). PMID: 26455392    Free PMC article.
Highly Cited.
Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites.
Seung-Tae Lee, Joseph L Wiemels.
Nucleic Acids Res, 2015 Oct 16; 44(3). PMID: 26464434    Free PMC article.
A Pyrosequencing Assay for the Quantitative Methylation Analysis of GALR1 in Endometrial Samples: Preliminary Results.
Christine Kottaridi, Nikolaos Koureas, +9 authors, Petros Karakitsos.
Biomed Res Int, 2015 Oct 28; 2015. PMID: 26504828    Free PMC article.
Epigenetic Heterogeneity of B-Cell Lymphoma: Chromatin Modifiers.
Lydia Hopp, Lilit Nersisyan, +2 authors, Hans Binder.
Genes (Basel), 2015 Oct 28; 6(4). PMID: 26506391    Free PMC article.
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
Cancer Genome Atlas Research Network, W Marston Linehan, +226 authors, Rosemary Zuna.
N Engl J Med, 2015 Nov 05; 374(2). PMID: 26536169    Free PMC article.
Highly Cited.
CBP binding outside of promoters and enhancers in Drosophila melanogaster.
Philge Philip, Ann Boija, +5 authors, Per Stenberg.
Epigenetics Chromatin, 2015 Nov 26; 8. PMID: 26604986    Free PMC article.
Genome-wide predictors of NF-κB recruitment and transcriptional activity.
Marcin Cieślik, Stefan Bekiranov.
BioData Min, 2015 Dec 01; 8. PMID: 26617673    Free PMC article.
Epigenetic dysregulation in follicular lymphoma.
Shamzah Araf, Jessica Okosun, +2 authors, James Heward.
Epigenomics, 2015 Dec 25; 8(1). PMID: 26698557    Free PMC article.
Review.
Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression.
Xiaoxu Zhou, Xiujuan Zang, +8 authors, Shougang Zhuang.
J Am Soc Nephrol, 2015 Dec 25; 27(7). PMID: 26701983    Free PMC article.
Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies.
Huihuang Yan, Shulan Tian, +2 authors, Tamas Ordog.
Am J Epidemiol, 2016 Jan 02; 183(2). PMID: 26721890    Free PMC article.
Identification of DNA Methylation-Independent Epigenetic Events Underlying Clear Cell Renal Cell Carcinoma.
Elinne Becket, Sameer Chopra, +9 authors, Gangning Liang.
Cancer Res, 2016 Jan 14; 76(7). PMID: 26759245    Free PMC article.
Epigenetic Therapeutics: A New Weapon in the War Against Cancer.
Nita Ahuja, Anup R Sharma, Stephen B Baylin.
Annu Rev Med, 2016 Jan 16; 67. PMID: 26768237    Free PMC article.
Highly Cited. Review.
Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites.
Maria Jung, Svenja Pützer, +3 authors, Dimo Dietrich.
Clin Epigenetics, 2016 Mar 05; 8. PMID: 26937257    Free PMC article.
The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells.
María J Ruiz-Magaña, Rocío Martínez-Aguilar, +3 authors, Carmen Ruiz-Ruiz.
Oncotarget, 2016 Mar 05; 7(16). PMID: 26942461    Free PMC article.
The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation.
Zhenfang Du, Lili Li, +4 authors, Qian Tao.
Oncotarget, 2016 Mar 05; 7(16). PMID: 26943038    Free PMC article.
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression.
Andrew P Feinberg, Michael A Koldobskiy, Anita Göndör.
Nat Rev Genet, 2016 Mar 15; 17(5). PMID: 26972587    Free PMC article.
Highly Cited. Review.
Inactivation of the WNT5A Alternative Promoter B Is Associated with DNA Methylation and Histone Modification in Osteosarcoma Cell Lines U2OS and SaOS-2.
Himani Vaidya, Candie Rumph, Karen S Katula.
PLoS One, 2016 Mar 16; 11(3). PMID: 26978652    Free PMC article.
Combining Epigenetic and Immunotherapy to Combat Cancer.
Katherine B Chiappinelli, Cynthia A Zahnow, Nita Ahuja, Stephen B Baylin.
Cancer Res, 2016 Mar 19; 76(7). PMID: 26988985    Free PMC article.
Highly Cited. Review.
Histone Modifications and Cancer.
James E Audia, Robert M Campbell.
Cold Spring Harb Perspect Biol, 2016 Apr 03; 8(4). PMID: 27037415    Free PMC article.
Highly Cited. Review.
De novo deciphering three-dimensional chromatin interaction and topological domains by wavelet transformation of epigenetic profiles.
Yong Chen, Yunfei Wang, +2 authors, Michael Q Zhang.
Nucleic Acids Res, 2016 Apr 10; 44(11). PMID: 27060148    Free PMC article.
Intratumoral Heterogeneity of the Epigenome.
Tali Mazor, Aleksandr Pankov, Jun S Song, Joseph F Costello.
Cancer Cell, 2016 Apr 14; 29(4). PMID: 27070699    Free PMC article.
Highly Cited. Review.
Cancer Stem Cells: Dynamic Entities in an Ever-Evolving Paradigm.
Hernando Lopez-Bertoni, Yunqing Li, John Laterra.
Biol Med (Aligarh), 2016 May 10; 7(Suppl 2). PMID: 27158195    Free PMC article.
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.
Zhuo Chen, Feng Miao, +11 authors, Rama Natarajan.
Proc Natl Acad Sci U S A, 2016 May 11; 113(21). PMID: 27162351    Free PMC article.
Highly Cited.
Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.
Tokuhiro Chano, Sofia Avnet, +5 authors, Nicola Baldini.
Am J Cancer Res, 2016 May 18; 6(4). PMID: 27186436    Free PMC article.
Practical aspects of NGS-based pathways analysis for personalized cancer science and medicine.
Ekaterina A Kotelnikova, Mikhail Pyatnitskiy, +2 authors, Dmitriy Vinogradov.
Oncotarget, 2016 May 19; 7(32). PMID: 27191992    Free PMC article.
Review.
Epigenetic Determinants of Cancer.
Stephen B Baylin, Peter A Jones.
Cold Spring Harb Perspect Biol, 2016 May 20; 8(9). PMID: 27194046    Free PMC article.
Highly Cited. Review.
New Strategies for the Treatment of Solid Tumors with CAR-T Cells.
Hao Zhang, Zhen-Long Ye, +3 authors, Qi-Jun Qian.
Int J Biol Sci, 2016 May 20; 12(6). PMID: 27194949    Free PMC article.
Review.
Compartmentation of metabolites in regulating epigenome of cancer.
Zhiqiang Zhao, Li Wang, Lijun Di.
Mol Med, 2016 Jun 04; 22. PMID: 27258652    Free PMC article.
MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation.
Angelina Stojanova, William B Tu, +7 authors, Linda Z Penn.
Cell Cycle, 2016 Jun 09; 15(13). PMID: 27267444    Free PMC article.
Renal Cancer Stem Cells: Characterization and Targeted Therapies.
Anna Julie Peired, Alessandro Sisti, Paola Romagnani.
Stem Cells Int, 2016 Jun 14; 2016. PMID: 27293448    Free PMC article.
Review.
Mitochondrial Epigenetics and Environmental Exposure.
Luca Lambertini, Hyang-Min Byun.
Curr Environ Health Rep, 2016 Jun 28; 3(3). PMID: 27344144
Review.
Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis.
Chi-Yeh Chung, Zhen Sun, +10 authors, Emily Bernstein.
Cell Rep, 2016 Jun 28; 16(2). PMID: 27346354    Free PMC article.
Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment.
Julia Krushkal, Yingdong Zhao, +3 authors, Richard Simon.
Clin Epigenetics, 2016 Jun 28; 8. PMID: 27347216    Free PMC article.
Long noncoding RNAs in DNA methylation: new players stepping into the old game.
Yu Zhao, Hao Sun, Huating Wang.
Cell Biosci, 2016 Jul 14; 6. PMID: 27408682    Free PMC article.
Review.
Cross-species Analyses Unravel the Complexity of H3K27me3 and H4K20me3 in the Context of Neural Stem Progenitor Cells.
Christopher T Rhodes, Richard S Sandstrom, +4 authors, Chin-Hsing Annie Lin.
Neuroepigenetics, 2016 Jul 19; 6. PMID: 27429906    Free PMC article.
Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas.
Annette M Lim, Nicholas C Wong, +6 authors, Benjamin Solomon.
Clin Epigenetics, 2016 Jul 20; 8. PMID: 27433284    Free PMC article.
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing.
Wenqiang Liu, Xiaoyu Liu, +14 authors, Shaorong Gao.
Cell Discov, 2016 Jul 28; 2. PMID: 27462457    Free PMC article.
Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis.
Waqas Iqbal, Saleh Alkarim, +2 authors, Kulvinder S Saini.
Oncotarget, 2016 Aug 04; 7(46). PMID: 27486983    Free PMC article.
Review.
Insights into newly discovered marks and readers of epigenetic information.
Forest H Andrews, Brian D Strahl, Tatiana G Kutateladze.
Nat Chem Biol, 2016 Aug 19; 12(9). PMID: 27538025    Free PMC article.
Review.
Metabolic interactions with cancer epigenetics.
Xia Gao, Michael A Reid, Mei Kong, Jason W Locasale.
Mol Aspects Med, 2016 Sep 14; 54. PMID: 27620316    Free PMC article.
Review.
Development of chidamide for peripheral T-cell lymphoma, the first orphan drug approved in China.
Xianping Lu, Zhiqiang Ning, +2 authors, Xinhao Wang.
Intractable Rare Dis Res, 2016 Sep 28; 5(3). PMID: 27672541    Free PMC article.
Review.
The anticancer effects of Resina Draconis extract on cholangiocarcinoma.
Feng Wen, Xiangxuan Zhao, +2 authors, Qiyong Guo.
Tumour Biol, 2016 Sep 30; 37(11). PMID: 27683055
Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.
Melanie R Hassler, Walter Pulverer, +11 authors, Gerda Egger.
Cell Rep, 2016 Oct 06; 17(2). PMID: 27705804    Free PMC article.
DNA Methylation Patterns in Rat Mammary Carcinomas Induced by Pre- and Post-Pubertal Irradiation.
Masaru Takabatake, Benjamin J Blyth, +4 authors, Yoshiya Shimada.
PLoS One, 2016 Oct 07; 11(10). PMID: 27711132    Free PMC article.
Putative RNA-directed adaptive mutations in cancer evolution.
Didier Auboeuf.
Transcription, 2016 Oct 08; 7(5). PMID: 27715501    Free PMC article.
Epigenetics in Cancer: A Hematological Perspective.
Maximilian Stahl, Nathan Kohrman, +3 authors, Thomas Prebet.
PLoS Genet, 2016 Oct 11; 12(10). PMID: 27723796    Free PMC article.
Review.
Epigenetic determinants of metastasis.
Saroor A Patel, Sakari Vanharanta.
Mol Oncol, 2016 Oct 21; 11(1). PMID: 27756687    Free PMC article.
Review.
RNAi screens identify CHD4 as an essential gene in breast cancer growth.
Carolina D'Alesio, Simona Punzi, +11 authors, Luisa Lanfrancone.
Oncotarget, 2016 Oct 26; 7(49). PMID: 27779108    Free PMC article.
Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes.
Michela Boi, Maria Todaro, +14 authors, AIRC 5xMille Consortium ‘Genetics-Driven Targeted Management of Lymphoid Malignancies’.
Oncotarget, 2016 Oct 30; 7(48). PMID: 27793034    Free PMC article.
PD-L1 promoter methylation is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy.
Heidrun Gevensleben, Emily Eva Holmes, +5 authors, Glen Kristiansen.
Oncotarget, 2016 Nov 12; 7(48). PMID: 27835597    Free PMC article.
Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems.
Ronald P Schuyler, Angelika Merkel, +18 authors, Simon Heath.
Cell Rep, 2016 Nov 17; 17(8). PMID: 27851971    Free PMC article.
Oncogenic Mechanisms of Histone H3 Mutations.
Daniel N Weinberg, C David Allis, Chao Lu.
Cold Spring Harb Perspect Med, 2016 Nov 20; 7(1). PMID: 27864305    Free PMC article.
Review.
The Emergence of Pan-Cancer CIMP and Its Elusive Interpretation.
Brendan F Miller, Francisco Sánchez-Vega, Laura Elnitski.
Biomolecules, 2016 Nov 24; 6(4). PMID: 27879658    Free PMC article.
Review.
Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains.
Yang Gao, Andrew E Teschendorff.
Nucleic Acids Res, 2016 Dec 03; 45(2). PMID: 27899617    Free PMC article.
Genetic and Epigenetic Alterations in Bladder Cancer.
Hong-Tao Li, Christopher E Duymich, Daniel J Weisenberger, Gangning Liang.
Int Neurourol J, 2016 Dec 06; 20(Suppl 2). PMID: 27915480    Free PMC article.
Review.
Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes.
Wanding Zhou, Peter W Laird, Hui Shen.
Nucleic Acids Res, 2016 Dec 08; 45(4). PMID: 27924034    Free PMC article.
Highly Cited.
Endogenous retroviral promoter exaptation in human cancer.
Artem Babaian, Dixie L Mager.
Mob DNA, 2016 Dec 17; 7. PMID: 27980689    Free PMC article.
Highly Cited. Review.
Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.
Fusheng Zhou, Changbing Shen, +16 authors, Xuejun Zhang.
Clin Epigenetics, 2016 Dec 17; 8. PMID: 27980695    Free PMC article.
Promoter hypermethylation of SHOX2 and SEPT9 is a potential biomarker for minimally invasive diagnosis in adenocarcinomas of the biliary tract.
V Branchi, P Schaefer, +7 authors, H Matthaei.
Clin Epigenetics, 2016 Dec 22; 8. PMID: 27999621    Free PMC article.
Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer.
Carl Koschmann, Felipe J Nunez, +4 authors, Maria G Castro.
Cancer Res, 2017 Jan 08; 77(2). PMID: 28062403    Free PMC article.
Review.
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.
Yang W Zhang, Zhihong Wang, +7 authors, Stephen B Baylin.
Mol Cell, 2017 Jan 21; 65(2). PMID: 28107650    Free PMC article.
Highly Cited.
Constitutional Epi/Genetic Conditions: Genetic, Epigenetic, and Environmental Factors.
Laila C Schenkel, David Rodenhiser, +3 authors, Bekim Sadikovic.
J Pediatr Genet, 2017 Feb 10; 6(1). PMID: 28180025    Free PMC article.
Review.
A chemical probe toolbox for dissecting the cancer epigenome.
Jake Shortt, Christopher J Ott, Ricky W Johnstone, James E Bradner.
Nat Rev Cancer, 2017 Feb 24; 17(3). PMID: 28228643
Highly Cited. Review.
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells.
Yi Cai, Hsing-Chen Tsai, +5 authors, Stephen B Baylin.
Genome Res, 2017 Feb 25; 27(4). PMID: 28232479    Free PMC article.
Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells.
Jung Seon Seo, Young Ha Choi, +2 authors, Sun-Hwa Park.
BMC Cell Biol, 2017 Mar 01; 18(1). PMID: 28241740    Free PMC article.
Comparative analyses identify molecular signature of MRI-classified SVZ-associated glioblastoma.
Chin-Hsing Annie Lin, Christopher T Rhodes, +2 authors, Mitchel S Berger.
Cell Cycle, 2017 Mar 10; 16(8). PMID: 28278055    Free PMC article.
Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome.
Laila C Schenkel, Kristin D Kernohan, +10 authors, Bekim Sadikovic.
Epigenetics Chromatin, 2017 Mar 16; 10. PMID: 28293299    Free PMC article.
Kilobase Pair Chromatin Fiber Contacts Promoted by Living-System-Like DNA Linker Length Distributions and Nucleosome Depletion.
Gavin D Bascom, Taejin Kim, Tamar Schlick.
J Phys Chem B, 2017 Mar 17; 121(15). PMID: 28299939    Free PMC article.
Hypomethylation of interleukin-6 (IL-6) gene increases the risk of essential hypertension: a matched case-control study.
S-Q Mao, J-H Sun, +3 authors, L-N Zhang.
J Hum Hypertens, 2017 Mar 17; 31(8). PMID: 28300071
CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies.
Francisco Sánchez-Vega, Valer Gotea, Yun-Ching Chen, Laura Elnitski.
World J Gastrointest Oncol, 2017 Mar 28; 9(3). PMID: 28344746    Free PMC article.
DNA methylation aberrancies as a guide for surveillance and treatment of human cancers.
Gangning Liang, Daniel J Weisenberger.
Epigenetics, 2017 Mar 31; 12(6). PMID: 28358281    Free PMC article.
Review.
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ.
Lorenzo Rinaldi, Alexandra Avgustinova, +4 authors, Salvador Aznar Benitah.
Elife, 2017 Apr 21; 6. PMID: 28425913    Free PMC article.
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.
Limin Xia, Wenjie Huang, +13 authors, Stephen B Baylin.
Cancer Cell, 2017 May 10; 31(5). PMID: 28486105    Free PMC article.
Highly Cited.
Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A.
Andrea Halaburková, Rastislav Jendželovský, +3 authors, Akram Ghantous.
Clin Epigenetics, 2017 Jun 13; 9. PMID: 28603560    Free PMC article.
Epigenetic plasticity and the hallmarks of cancer.
William A Flavahan, Elizabeth Gaskell, Bradley E Bernstein.
Science, 2017 Jul 22; 357(6348). PMID: 28729483    Free PMC article.
Highly Cited. Review.
A step-by-step microRNA guide to cancer development and metastasis.
Georgios S Markopoulos, Eugenia Roupakia, +7 authors, Evangelos Kolettas.
Cell Oncol (Dordr), 2017 Jul 28; 40(4). PMID: 28748501
Highly Cited. Review.
Biosynthesis of brain cytoplasmic 200 RNA.
Youngmi Kim, Jungmin Lee, +3 authors, Younghoon Lee.
Sci Rep, 2017 Aug 02; 7(1). PMID: 28761139    Free PMC article.
PiiL: visualization of DNA methylation and gene expression data in gene pathways.
Behrooz Torabi Moghadam, Neda Zamani, Jan Komorowski, Manfred Grabherr.
BMC Genomics, 2017 Aug 05; 18(1). PMID: 28768481    Free PMC article.
Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses.
Trillitye Paullin, Chase Powell, +4 authors, Sandy D Westerheide.
PLoS One, 2017 Aug 10; 12(8). PMID: 28793334    Free PMC article.
The impact of methylation quantitative trait loci (mQTLs) on active smoking-related DNA methylation changes.
Xu Gao, Hauke Thomsen, +2 authors, Hermann Brenner.
Clin Epigenetics, 2017 Aug 22; 9. PMID: 28824732    Free PMC article.
Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.
Michelle Vaz, Stephen Y Hwang, +9 authors, Stephen B Baylin.
Cancer Cell, 2017 Sep 13; 32(3). PMID: 28898697    Free PMC article.
Highly Cited.
Prostate cancer diagnosis using epigenetic biomarkers, 3D high-content imaging and probabilistic cell-by-cell classifiers.
Darko Stefanovski, George Tang, +3 authors, Jian Tajbakhsh.
Oncotarget, 2017 Sep 17; 8(34). PMID: 28915670    Free PMC article.
Introduction: Cancer as an Epigenetic Disease.
Jean-Pierre J Issa.
Cancer J, 2017 Sep 20; 23(5). PMID: 28926424    Free PMC article.
Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.
Shoji Maenohara, Motoko Unoki, +4 authors, Hiroyuki Sasaki.
PLoS Genet, 2017 Oct 05; 13(10). PMID: 28976982    Free PMC article.
Clonal evolution in leukemia.
Adolfo A Ferrando, Carlos López-Otín.
Nat Med, 2017 Oct 07; 23(10). PMID: 28985206
Review.
The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis.
Changwen Wang, Wen Yang, +4 authors, Tao Huang.
Oncotarget, 2017 Oct 17; 8(39). PMID: 29029516    Free PMC article.
Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications.
Tathiane M Malta, Camila F de Souza, +6 authors, Houtan Noushmehr.
Neuro Oncol, 2017 Oct 17; 20(5). PMID: 29036500    Free PMC article.
Review.
CR2Cancer: a database for chromatin regulators in human cancer.
Beibei Ru, Jianlong Sun, +7 authors, Jiangwen Zhang.
Nucleic Acids Res, 2017 Oct 17; 46(D1). PMID: 29036683    Free PMC article.
DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.
Candace J Poole, Wenli Zheng, +5 authors, Jan van Riggelen.
Oncotarget, 2017 Nov 05; 8(44). PMID: 29100357    Free PMC article.
Significant associations between driver gene mutations and DNA methylation alterations across many cancer types.
Yun-Ching Chen, Valer Gotea, Gennady Margolin, Laura Elnitski.
PLoS Comput Biol, 2017 Nov 11; 13(11). PMID: 29125844    Free PMC article.
Molecular determinants of prostate cancer metastasis.
Kiera Rycaj, Dean G Tang.
Oncotarget, 2017 Nov 21; 8(50). PMID: 29152153    Free PMC article.
Review.
Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer.
Andrija Matak, Pooja Lahiri, +5 authors, Kurt Zatloukal.
Hepatology, 2017 Nov 25; 68(3). PMID: 29171037    Free PMC article.
Cell surface GRP78 promotes tumor cell histone acetylation through metabolic reprogramming: a mechanism which modulates the Warburg effect.
Udhayakumar Gopal, Salvatore V Pizzo.
Oncotarget, 2018 Jan 04; 8(64). PMID: 29296215    Free PMC article.
Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes.
Erfan Aref-Eshghi, David I Rodenhiser, +12 authors, Bekim Sadikovic.
Am J Hum Genet, 2018 Jan 06; 102(1). PMID: 29304373    Free PMC article.
Highly Cited.
Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice.
Daniele Viarisio, Karin Müller-Decker, +13 authors, Massimo Tommasino.
PLoS Pathog, 2018 Jan 13; 14(1). PMID: 29324843    Free PMC article.
Highly Cited.
LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations.
Yongsheng Li, Lili Li, +10 authors, Xia Li.
Nucleic Acids Res, 2018 Jan 13; 46(3). PMID: 29325141    Free PMC article.
The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers.
Yui-Ping Weng, Pin-Feng Hung, +6 authors, Chia-Huei Lee.
Oncotarget, 2018 Feb 09; 9(1). PMID: 29416619    Free PMC article.
DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.
Wenbing Xie, Ioannis Kagiampakis, +13 authors, Hariharan Easwaran.
Cancer Cell, 2018 Feb 14; 33(2). PMID: 29438699    Free PMC article.
Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer.
Mariangela Morlando, Alessandro Fatica.
Int J Mol Sci, 2018 Feb 15; 19(2). PMID: 29443889    Free PMC article.
Highly Cited. Review.
Beyond molecular tumor heterogeneity: protein synthesis takes control.
Santiago Ramon Y Cajal, Josep Castellvi, +3 authors, Nahum Sonenberg.
Oncogene, 2018 Feb 22; 37(19). PMID: 29463861    Free PMC article.
Review.
Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression.
Linda Xiaoyan Li, Julie Xia Zhou, +3 authors, Xiaogang Li.
Cell Death Dis, 2018 Mar 01; 9(3). PMID: 29487338    Free PMC article.
From Chemotherapy to Combined Targeted Therapeutics: In Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity.
Guido Gambara, Manuela Gaebler, +2 authors, Alessandra Silvestri.
Front Pharmacol, 2018 Mar 02; 9. PMID: 29491834    Free PMC article.
Review.
TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma.
Hitoshi Itoh, Tsuyoshi Kadomatsu, +10 authors, Yuichi Oike.
Oncogene, 2018 Mar 09; 37(22). PMID: 29515232
The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.
Youqiong Ye, Yu Xiang, +15 authors, Leng Han.
Cell Syst, 2018 Mar 12; 6(3). PMID: 29525205    Free PMC article.
Highly Cited.
The association between copy number aberration, DNA methylation and gene expression in tumor samples.
Wei Sun, Paul Bunn, +6 authors, Dan-Yu Lin.
Nucleic Acids Res, 2018 Mar 13; 46(6). PMID: 29529299    Free PMC article.
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
Zehua Wang, Bo Yang, +8 authors, Da Yang.
Cancer Cell, 2018 Apr 07; 33(4). PMID: 29622465    Free PMC article.
Highly Cited.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Challenges and prospects of chimeric antigen receptor T cell therapy in solid tumors.
Vishal Jindal, Ena Arora, Sorab Gupta.
Med Oncol, 2018 May 08; 35(6). PMID: 29730801
Review.
Applications of RNA Indexes for Precision Oncology in Breast Cancer.
Liming Ma, Zirui Liang, Hui Zhou, Lianghu Qu.
Genomics Proteomics Bioinformatics, 2018 May 13; 16(2). PMID: 29753129    Free PMC article.
Review.
The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is frequently methylated in oesophageal squamous cell carcinoma and antagonises Wnt/β-catenin signalling.
Chong Zhang, Tingxiu Xiang, +8 authors, Qian Tao.
Cell Death Dis, 2018 May 16; 9(5). PMID: 29760376    Free PMC article.
Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI-110) in Hepatocellular Carcinoma.
Minmin Liu, Lian Zhang, +10 authors, Gangning Liang.
Hepatology, 2018 May 19; 68(4). PMID: 29774579    Free PMC article.
Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis.
Xiaoxu Zhou, Chongxiang Xiong, +3 authors, Shougang Zhuang.
FASEB J, 2018 May 19;. PMID: 29775417    Free PMC article.
Tumorigenic Cell Reprogramming and Cancer Plasticity: Interplay between Signaling, Microenvironment, and Epigenetics.
Vittoria Poli, Luca Fagnocchi, Alessio Zippo.
Stem Cells Int, 2018 Jun 02; 2018. PMID: 29853913    Free PMC article.
Review.
Combined HAT/EZH2 modulation leads to cancer-selective cell death.
Francesca Petraglia, Abhishek A Singh, +32 authors, Lucia Altucci.
Oncotarget, 2018 Jun 08; 9(39). PMID: 29876013    Free PMC article.
Cancer epigenetics: Moving forward.
Angela Nebbioso, Francesco Paolo Tambaro, Carmela Dell'Aversana, Lucia Altucci.
PLoS Genet, 2018 Jun 08; 14(6). PMID: 29879107    Free PMC article.
Highly Cited. Review.
Tissue-specific DNA methylation loss during ageing and carcinogenesis is linked to chromosome structure, replication timing and cell division rates.
Marija Dmitrijeva, Stephan Ossowski, Luis Serrano, Martin H Schaefer.
Nucleic Acids Res, 2018 Jun 13; 46(14). PMID: 29893918    Free PMC article.
Integrated Molecular Characterization of Testicular Germ Cell Tumors.
Hui Shen, Juliann Shih, +48 authors, Katherine A Hoadley.
Cell Rep, 2018 Jun 14; 23(11). PMID: 29898407    Free PMC article.
Highly Cited.
Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR.
Sam Kint, Ward De Spiegelaere, +2 authors, Wim Van Criekinge.
PLoS One, 2018 Jun 15; 13(6). PMID: 29902267    Free PMC article.
Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study.
Ben-Gang Wang, Qian Xu, +4 authors, Yuan Yuan.
World J Gastroenterol, 2018 Jun 23; 24(23). PMID: 29930469    Free PMC article.
Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence.
Margreet C M Vissers, Andrew B Das.
Front Physiol, 2018 Jul 19; 9. PMID: 30018566    Free PMC article.
Review.
SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions.
Wanding Zhou, Timothy J Triche, Peter W Laird, Hui Shen.
Nucleic Acids Res, 2018 Aug 08; 46(20). PMID: 30085201    Free PMC article.
Diet and the epigenome.
Yi Zhang, Tatiana G Kutateladze.
Nat Commun, 2018 Aug 30; 9(1). PMID: 30154441    Free PMC article.
Dual Inhibition of DNA and Histone Methyltransferases Increases Viral Mimicry in Ovarian Cancer Cells.
Minmin Liu, Stacey L Thomas, +6 authors, Peter A Jones.
Cancer Res, 2018 Sep 07; 78(20). PMID: 30185548    Free PMC article.
Targeting enhancer of zeste homolog 2 protects against acute kidney injury.
X Zhou, X Zang, +4 authors, S Zhuang.
Cell Death Dis, 2018 Oct 21; 9(11). PMID: 30341286    Free PMC article.
A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes.
Ahrim Youn, Kyung In Kim, +3 authors, Shuang Wang.
BMC Med Genomics, 2018 Nov 08; 11(1). PMID: 30400878    Free PMC article.
LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression.
Xin Hu, Dongxi Xiang, +7 authors, Zhe Li.
Oncogene, 2019 Aug 15; 38(44). PMID: 31409898    Free PMC article.
Genetic Variants of lncRNA MALAT1 Exert Diverse Impacts on the Risk and Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma.
Lan-Ting Yuan, Jer-Hwa Chang, +5 authors, Ming-Hsien Chien.
J Clin Med, 2019 Sep 11; 8(9). PMID: 31500187    Free PMC article.
Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation.
Georgios S Markopoulos, Eugenia Roupakia, Kenneth B Marcu, Evangelos Kolettas.
Cells, 2019 Sep 29; 8(10). PMID: 31557902    Free PMC article.
Review.
Epigenetic Mechanisms of Escape from BRAF Oncogene Dependency.
Mehwish Khaliq, Mohammad Fallahi-Sichani.
Cancers (Basel), 2019 Oct 05; 11(10). PMID: 31581557    Free PMC article.
Review.
MicroRNAs and Epigenetics Strategies to Reverse Breast Cancer.
Mohammad Mijanur Rahman, Andrew C Brane, Trygve O Tollefsbol.
Cells, 2019 Oct 11; 8(10). PMID: 31597272    Free PMC article.
Review.
LINC00460 Hypomethylation Promotes Metastasis in Colorectal Carcinoma.
Hui Zhang, Ya Lu, Jianzhong Wu, Jifeng Feng.
Front Genet, 2019 Oct 22; 10. PMID: 31632435    Free PMC article.
Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas.
Jong-Whi Park, Şevin Turcan.
Cancers (Basel), 2019 Oct 28; 11(10). PMID: 31652645    Free PMC article.
Review.
LncRNAs as Chromatin Regulators in Cancer: From Molecular Function to Clinical Potential.
Rodiola Begolli, Nikos Sideris, Antonis Giakountis.
Cancers (Basel), 2019 Oct 30; 11(10). PMID: 31658672    Free PMC article.
Review.
Epigenetic heterogeneity in cancer.
Mingzhou Guo, Yaojun Peng, +2 authors, James G Herman.
Biomark Res, 2019 Nov 07; 7. PMID: 31695915    Free PMC article.
Review.
Epigenetic modifications of histones in cancer.
Zibo Zhao, Ali Shilatifard.
Genome Biol, 2019 Nov 22; 20(1). PMID: 31747960    Free PMC article.
Highly Cited. Review.
DNA Methyltransferase Inhibitors: Catalysts For Antitumour Immune Responses.
Huimin Dan, Shanshan Zhang, Yongning Zhou, Quanlin Guan.
Onco Targets Ther, 2019 Dec 19; 12. PMID: 31849494    Free PMC article.
Review.
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.
Yuan Cheng, Cai He, +5 authors, Xiawei Wei.
Signal Transduct Target Ther, 2019 Dec 25; 4. PMID: 31871779    Free PMC article.
Highly Cited. Review.
DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.
Felix K F Kommoss, Damian Stichel, +22 authors, Christian Koelsche.
J Cancer Res Clin Oncol, 2019 Nov 27; 146(1). PMID: 31768620
Genistein Modulates Signaling Pathways and Targets Several Epigenetic Markers in HeLa Cells.
Madhumitha Kedhari Sundaram, Sreepoorna Unni, +4 authors, Shafiul Haque.
Genes (Basel), 2019 Nov 27; 10(12). PMID: 31766427    Free PMC article.
A comparative analysis of cell-type adjustment methods for epigenome-wide association studies based on simulated and real data sets.
Johannes Brägelmann, Justo Lorenzo Bermejo.
Brief Bioinform, 2018 Aug 14; 20(6). PMID: 30099476    Free PMC article.
Review.
Machine Learning and Network Analyses Reveal Disease Subtypes of Pancreatic Cancer and their Molecular Characteristics.
Musalula Sinkala, Nicola Mulder, Darren Martin.
Sci Rep, 2020 Jan 29; 10(1). PMID: 31988390    Free PMC article.
STAT3 activates MSK1-mediated histone H3 phosphorylation to promote NFAT signaling in gastric carcinogenesis.
Hongyan Qi, Zhiyi Yang, +9 authors, Jing Shen.
Oncogenesis, 2020 Feb 12; 9(2). PMID: 32041943    Free PMC article.
DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma.
Chenfei Lu, Yutian Wei, +8 authors, Yongping You.
Mol Cancer, 2020 Feb 11; 19(1). PMID: 32039732    Free PMC article.
Clinical implications of intratumor heterogeneity: challenges and opportunities.
Santiago Ramón Y Cajal, Marta Sesé, +5 authors, Josep Castellví.
J Mol Med (Berl), 2020 Jan 24; 98(2). PMID: 31970428    Free PMC article.
Review.
The transcriptional landscape of lncRNAs reveals the oncogenic function of LINC00511 in ER-negative breast cancer.
Jian Zhang, Shiyao Sui, +4 authors, Da Pang.
Cell Death Dis, 2019 Aug 10; 10(8). PMID: 31395854    Free PMC article.
SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways.
Cinzia Bottino, Alessia Peserico, Cristiano Simone, Giuseppina Caretti.
Cancers (Basel), 2020 Jan 16; 12(1). PMID: 31935919    Free PMC article.
Review.
Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.
Sinead Toomey, Aoife Carr, +25 authors, Bryan T Hennessy.
J Transl Med, 2020 Feb 24; 18(1). PMID: 32087721    Free PMC article.
An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis.
Vojtech Novohradsky, Lenka Markova, +3 authors, Jana Kasparkova.
Sci Rep, 2019 Sep 19; 9(1). PMID: 31527683    Free PMC article.
PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent.
Chengli Song, Lina Wang, +9 authors, Qingkai Yang.
Cancer Res, 2018 May 08; 78(10). PMID: 29735542    Free PMC article.
The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia.
Renée Beekman, Vicente Chapaprieta, +48 authors, Jose I Martin-Subero.
Nat Med, 2018 May 23; 24(6). PMID: 29785028    Free PMC article.
Highly Cited.
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.
Anil Korkut, Sobia Zaidi, +43 authors, Rehan Akbani.
Cell Syst, 2018 Oct 01; 7(4). PMID: 30268436    Free PMC article.
Highly Cited.
N 6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals.
Jun Xiong, Tian-Tian Ye, +3 authors, Yu-Qi Feng.
Nucleic Acids Res, 2018 Dec 06; 47(3). PMID: 30517733    Free PMC article.
Targeting Chromatin Remodeling for Cancer Therapy.
Jasmine Kaur, Abdelkader Daoud, Scott T Eblen.
Curr Mol Pharmacol, 2019 Feb 16; 12(3). PMID: 30767757    Free PMC article.
Review.
The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome.
Hemant Gujar, Daniel J Weisenberger, Gangning Liang.
Genes (Basel), 2019 Mar 01; 10(2). PMID: 30813436    Free PMC article.
Review.
The expanding landscape of 'oncohistone' mutations in human cancers.
Benjamin A Nacev, Lijuan Feng, +7 authors, C David Allis.
Nature, 2019 Mar 22; 567(7749). PMID: 30894748    Free PMC article.
Highly Cited.
CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis.
Michael A Augello, Deli Liu, +15 authors, Christopher E Barbieri.
Cancer Cell, 2019 Apr 02; 35(4). PMID: 30930119    Free PMC article.
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.
Xiangqian Kong, Jie Chen, +15 authors, Stephen B Baylin.
Cancer Cell, 2019 Apr 09; 35(4). PMID: 30956060    Free PMC article.
BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition.
Nunzio Del Gaudio, Antonella Di Costanzo, +7 authors, Lucia Altucci.
Cell Death Dis, 2019 Apr 20; 10(5). PMID: 31000698    Free PMC article.
3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression.
Jun Ni, Xiying Hou, +6 authors, Shougang Zhuang.
Cell Death Dis, 2019 May 03; 10(5). PMID: 31043583    Free PMC article.
First Responder to Genomic Information: A Guide for Primary Care Providers.
Susanne B Haga.
Mol Diagn Ther, 2019 Jun 07; 23(4). PMID: 31172371    Free PMC article.
Review.
The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer.
Raheleh Amirkhah, Hojjat Naderi-Meshkin, +2 authors, Ulf Schmitz.
Cells, 2019 Aug 23; 8(8). PMID: 31430887    Free PMC article.
Review.
Collective effects of long-range DNA methylations predict gene expressions and estimate phenotypes in cancer.
Soyeon Kim, Hyun Jung Park, Xiangqin Cui, Degui Zhi.
Sci Rep, 2020 Mar 05; 10(1). PMID: 32127627    Free PMC article.
Development and Validation of a Prognostic Nomogram for Gastric Cancer Based on DNA Methylation-Driven Differentially Expressed Genes.
Yi Bai, Chunlian Wei, +7 authors, Haitao Zhao.
Int J Biol Sci, 2020 Mar 17; 16(7). PMID: 32174791    Free PMC article.
Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1.
Chenyin Wang, Alexandra Hamacher, +5 authors, Matthias U Kassack.
Cancers (Basel), 2020 Feb 08; 12(2). PMID: 32028599    Free PMC article.
MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL.
Candace J Poole, Atul Lodh, Jeong-Hyeon Choi, Jan van Riggelen.
Epigenetics Chromatin, 2019 Jul 04; 12(1). PMID: 31266538    Free PMC article.
Human endogenous retroviruses env gene expression and long terminal repeat methylation in colorectal cancer patients.
Maria Dolci, Chiara Favero, +9 authors, Serena Delbue.
Med Microbiol Immunol, 2020 Feb 11; 209(2). PMID: 32040616
Aneuploidy and gene expression: is there dosage compensation?
Shihoko Kojima, Daniela Cimini.
Epigenomics, 2019 Nov 23; 11(16). PMID: 31755744    Free PMC article.
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Coexpression patterns define epigenetic regulators associated with neurological dysfunction.
Leandros Boukas, James M Havrilla, +3 authors, Kasper D Hansen.
Genome Res, 2019 Mar 13; 29(4). PMID: 30858344    Free PMC article.
Dynamic Signatures of the Epigenome: Friend or Foe?
Marta Machnik, Urszula Oleksiewicz.
Cells, 2020 Mar 12; 9(3). PMID: 32156057    Free PMC article.
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Chromatin Architecture as an Essential Determinant of Dendritic Cell Function.
Giselle M Boukhaled, Mario Corrado, Hannah Guak, Connie M Krawczyk.
Front Immunol, 2019 Jun 20; 10. PMID: 31214161    Free PMC article.
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Three-Dimensional Nanoscale Nuclear Architecture Mapping of Rectal Biopsies Detects Colorectal Neoplasia in Patients with Inflammatory Bowel Disease.
Shikhar Uttam, Jana G Hashash, +5 authors, Yang Liu.
Cancer Prev Res (Phila), 2019 Jun 06; 12(8). PMID: 31164345    Free PMC article.
LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors.
Shaun Egolf, Yann Aubert, +10 authors, Brian C Capell.
Cell Rep, 2019 Aug 23; 28(8). PMID: 31433976    Free PMC article.
CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead.
Qingyang Zhang, Jieming Ping, +5 authors, Jianjun Ma.
J Immunol Res, 2020 May 16; 2020. PMID: 32411789    Free PMC article.
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The Mitochondrial Protein VDAC1 at the Crossroads of Cancer Cell Metabolism: The Epigenetic Link.
Zohar Amsalem, Tasleem Arif, +2 authors, Varda Shoshan-Barmatz.
Cancers (Basel), 2020 Apr 26; 12(4). PMID: 32331482    Free PMC article.
Integrative genomics approach identifies molecular features associated with early-stage ovarian carcinoma histotypes.
Hanna Engqvist, Toshima Z Parris, +6 authors, Khalil Helou.
Sci Rep, 2020 May 16; 10(1). PMID: 32409713    Free PMC article.
The emerging role of epigenetic therapeutics in immuno-oncology.
Michael J Topper, Michelle Vaz, +2 authors, Stephen B Baylin.
Nat Rev Clin Oncol, 2019 Sep 25; 17(2). PMID: 31548600    Free PMC article.
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Genome‑wide DNA methylation regulation analysis of long non‑coding RNAs in glioblastoma.
Jianghuai Ji, Lei Zhao, +4 authors, Dongguo Li.
Int J Mol Med, 2020 Apr 23; 46(1). PMID: 32319552    Free PMC article.
Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression.
Chatarina Larsson, Lina Cordeddu, +8 authors, Tobias Sjöblom.
Clin Epigenetics, 2020 May 31; 12(1). PMID: 32471474    Free PMC article.
Modulation of Apoptosis by Plant Polysaccharides for Exerting Anti-Cancer Effects: A Review.
Qing-Xia Gan, Jin Wang, +4 authors, Qin-Wan Huang.
Front Pharmacol, 2020 Jun 17; 11. PMID: 32536869    Free PMC article.
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Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants.
Karina M O'Connor, Andrew B Das, Christine C Winterbourn, Mark B Hampton.
J Biol Chem, 2020 Apr 22; 295(23). PMID: 32312750    Free PMC article.
NORAD orchestrates endometrial cancer progression by sequestering FUBP1 nuclear localization to promote cell apoptosis.
Tong Han, Yukang Wu, +8 authors, Xiaoping Wan.
Cell Death Dis, 2020 Jun 20; 11(6). PMID: 32555178    Free PMC article.
Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer.
Zekun Liu, Qi Zhao, +10 authors, Ze-Xian Liu.
iScience, 2020 Jul 07; 23(7). PMID: 32629423    Free PMC article.
Metabolic Adaptations in Cancer Stem Cells.
Umesh Prasad Yadav, Tashvinder Singh, +6 authors, Kapil Mehta.
Front Oncol, 2020 Jul 17; 10. PMID: 32670883    Free PMC article.
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The Role of DNA Methylation in Cancer.
Ranjani Lakshminarasimhan, Gangning Liang.
Adv Exp Med Biol, 2016 Nov 09; 945. PMID: 27826838    Free PMC article.
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p300 in Cardiac Development and Accelerated Cardiac Aging.
Asish K Ghosh.
Aging Dis, 2020 Aug 09; 11(4). PMID: 32765954    Free PMC article.
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Epigenetic mechanisms and the hallmarks of cancer: an intimate affair.
Nadine Darwiche.
Am J Cancer Res, 2020 Aug 11; 10(7). PMID: 32774995    Free PMC article.
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Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.
Amanda R Wasylishen, Chang Sun, +9 authors, Guillermina Lozano.
Sci Adv, 2020 Aug 22; 6(32). PMID: 32821827    Free PMC article.
Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K/AKT pathway.
Jinghui Liang, Haixia Li, +8 authors, Hui Tian.
Cell Death Dis, 2020 Aug 15; 11(8). PMID: 32792503    Free PMC article.
Epigenetic silencing of long non-coding RNA BM742401 in multiple myeloma: impact on prognosis and myeloma dissemination.
Zhenhai Li, Shaji Kumar, +5 authors, Chor Sang Chim.
Cancer Cell Int, 2020 Aug 29; 20. PMID: 32855620    Free PMC article.
Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference.
Paul J Hop, René Luijk, +13 authors, Bastiaan T Heijmans.
Genome Biol, 2020 Aug 30; 21(1). PMID: 32859263    Free PMC article.
Genetic Heterogeneity Between Paired Primary and Brain Metastases in Lung Adenocarcinoma.
Li Li, Zhulin Liu, +4 authors, Yong He.
Clin Med Insights Oncol, 2020 Sep 15; 14. PMID: 32922114    Free PMC article.
Epigenetic based synthetic lethal strategies in human cancers.
Aiai Gao, Mingzhou Guo.
Biomark Res, 2020 Sep 26; 8. PMID: 32974031    Free PMC article.
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Expression and methylation status of LAMA2 are associated with the invasiveness of nonfunctioning PitNET.
Ruo-Qiang Wang, Yu-Long Lan, +12 authors, Bo Zhang.
Ther Adv Endocrinol Metab, 2019 Feb 08; 10. PMID: 30728939    Free PMC article.
Genetic alteration of histone lysine methyltransferases and their significance in renal cell carcinoma.
Libin Yan, Yangjun Zhang, +3 authors, Hua Xu.
PeerJ, 2019 Feb 14; 7. PMID: 30755832    Free PMC article.
A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers.
Mafalda Ramos de Matos, Ioana Posa, +3 authors, Sérgio Fernandes de Almeida.
Cancers (Basel), 2019 Mar 23; 11(3). PMID: 30897760    Free PMC article.
Long Noncoding RNAs: Emerging Players in Medulloblastoma.
Pietro Laneve, Jessica Rea, Elisa Caffarelli.
Front Pediatr, 2019 Mar 30; 7. PMID: 30923703    Free PMC article.
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Hypomethylation of the promoter region drives ectopic expression of TMEM244 in Sézary cells.
Katarzyna Iżykowska, Karolina Rassek, +9 authors, Grzegorz K Przybylski.
J Cell Mol Med, 2020 Aug 15; 24(18). PMID: 32794659    Free PMC article.
Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors.
Yuhei Sangatsuda, Fumihito Miura, +13 authors, Takashi Ito.
Sci Rep, 2020 Oct 02; 10(1). PMID: 32999376    Free PMC article.
Epigenetic regulation of VENTXP1 suppresses tumor proliferation via miR-205-5p/ANKRD2/NF-kB signaling in head and neck squamous cell carcinoma.
Li Ming Zhang, Li Xin Su, +8 authors, Xin Dong Fan.
Cell Death Dis, 2020 Oct 11; 11(10). PMID: 33037177    Free PMC article.
Histone-Mutant Glioma: Molecular Mechanisms, Preclinical Models, and Implications for Therapy.
Maya S Graham, Ingo K Mellinghoff.
Int J Mol Sci, 2020 Oct 03; 21(19). PMID: 33003625    Free PMC article.
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tRNA-Derived Small RNAs: Novel Epigenetic Regulators.
Joonhyeong Park, Se Hee Ahn, +2 authors, Suhwan Chang.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992597    Free PMC article.
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Regulating Methylation at H3K27: A Trick or Treat for Cancer Cell Plasticity.
Provas Das, Joseph H Taube.
Cancers (Basel), 2020 Oct 03; 12(10). PMID: 33003334    Free PMC article.
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Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma.
Mayinuer Maitituoheti, Emily Z Keung, +29 authors, Kunal Rai.
Cell Rep, 2020 Oct 22; 33(3). PMID: 33086062    Free PMC article.
Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes.
Andrea Halaburkova, Vincent Cahais, +4 authors, Zdenko Herceg.
Genome Res, 2020 Sep 24; 30(10). PMID: 32963031    Free PMC article.
LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma.
Lukas Leiendecker, Pauline S Jung, +5 authors, Anna C Obenauf.
EMBO Mol Med, 2020 Oct 08; 12(11). PMID: 33026191    Free PMC article.
Multi-Omics Analysis Detects Novel Prognostic Subgroups of Breast Cancer.
Quang-Huy Nguyen, Hung Nguyen, Tin Nguyen, Duc-Hau Le.
Front Genet, 2020 Nov 17; 11. PMID: 33193681    Free PMC article.
Histone Variants: Guardians of Genome Integrity.
Juliette Ferrand, Beatrice Rondinelli, Sophie E Polo.
Cells, 2020 Nov 11; 9(11). PMID: 33167489    Free PMC article.
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Exercise and the Skeletal Muscle Epigenome.
Sean L McGee, Ken R Walder.
Cold Spring Harb Perspect Med, 2017 Mar 23; 7(9). PMID: 28320830    Free PMC article.
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Rational combination of cancer immunotherapy in melanoma.
Mario Mandalà, Piotr Rutkowski.
Virchows Arch, 2018 Dec 16; 474(4). PMID: 30552520
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The role of clonal communication and heterogeneity in breast cancer.
Ana Martín-Pardillos, Ángeles Valls Chiva, +16 authors, Santiago Ramón Y Cajal.
BMC Cancer, 2019 Jul 07; 19(1). PMID: 31277602    Free PMC article.
Extracellular Vesicles Released by Colorectal Cancer Cell Lines Modulate Innate Immune Response in Zebrafish Model: The Possible Role of Human Endogenous Retroviruses.
Luca Ferrari, Marco Cafora, +7 authors, Valentina Bollati.
Int J Mol Sci, 2019 Jul 31; 20(15). PMID: 31357477    Free PMC article.
The Inhibitory Effect of (-)-Epigallocatechin-3-Gallate on Breast Cancer Progression via Reducing SCUBE2 Methylation and DNMT Activity.
Jie Sheng, Weilin Shi, +5 authors, Yao Xu.
Molecules, 2019 Aug 14; 24(16). PMID: 31404982    Free PMC article.
Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer.
Piotr Przanowski, Song Lou, +12 authors, Sanchita Bhatnagar.
Cancer Res, 2020 Aug 29; 80(21). PMID: 32855208    Free PMC article.
Diagnostic Utility of Genome-Wide DNA Methylation Analysis in Mendelian Neurodevelopmental Disorders.
Sadegheh Haghshenas, Pratibha Bhai, Erfan Aref-Eshghi, Bekim Sadikovic.
Int J Mol Sci, 2020 Dec 10; 21(23). PMID: 33291301    Free PMC article.
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Extended transcriptome analysis reveals genome-wide lncRNA-mediated epigenetic dysregulation in colorectal cancer.
Sha He, Juanzhi Chen, +4 authors, Hao Zhu.
Comput Struct Biotechnol J, 2020 Dec 12; 18. PMID: 33304451    Free PMC article.

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Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis.
Huihui Fan, Huda I Atiya, +12 authors, Lan G Coffman.
Cell Rep, 2020 Dec 10; 33(10). PMID: 33296650    Free PMC article.
First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia.
Olga Salamero, Pau Montesinos, +13 authors, Tim C P Somervaille.
J Clin Oncol, 2020 Oct 15; 38(36). PMID: 33052756    Free PMC article.
Cancer's epigenetic drugs: where are they in the cancer medicines?
Sorayya Ghasemi.
Pharmacogenomics J, 2019 Dec 11; 20(3). PMID: 31819161
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Down-regulation of ACACA suppresses the malignant progression of Prostate Cancer through inhibiting mitochondrial potential.
Hui Zhang, Shaoyou Liu, +16 authors, Weide Zhong.
J Cancer, 2021 Jan 05; 12(1). PMID: 33391420    Free PMC article.
Neuroblastoma and the epigenome.
Irfete S Fetahu, Sabine Taschner-Mandl.
Cancer Metastasis Rev, 2021 Jan 07; 40(1). PMID: 33404859    Free PMC article.
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DNA Methylation in Ovarian Cancer Susceptibility.
Brett M Reid, Brooke L Fridley.
Cancers (Basel), 2021 Jan 06; 13(1). PMID: 33396385    Free PMC article.
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SCISSOR: a framework for identifying structural changes in RNA transcripts.
Hyo Young Choi, Heejoon Jo, +7 authors, D Neil Hayes.
Nat Commun, 2021 Jan 14; 12(1). PMID: 33436599    Free PMC article.
MethylationToActivity: a deep-learning framework that reveals promoter activity landscapes from DNA methylomes in individual tumors.
Justin Williams, Beisi Xu, +4 authors, Xiang Chen.
Genome Biol, 2021 Jan 20; 22(1). PMID: 33461601    Free PMC article.
Epigenetic silencing of LncRNA LINC00261 promotes c-myc-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1.
Shuyu Zhai, Zhiwei Xu, +7 authors, Xiaxing Deng.
Oncogene, 2020 Oct 31; 40(2). PMID: 33122827    Free PMC article.
Drosophila melanogaster: a fruitful model for oncohistones.
Amel Chaouch, Paul Lasko.
Fly (Austin), 2021 Jan 12; 15(1). PMID: 33423597    Free PMC article.
Expression of epigenetic modifiers is not significantly altered by exposure to secondhand smoke.
Stella Tommasi, Albert Zheng, Ahmad Besaratinia.
Lung Cancer, 2015 Nov 04; 90(3). PMID: 26525280    Free PMC article.
Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail.
Brandon R Lowe, Rajesh K Yadav, +10 authors, Janet F Partridge.
Elife, 2021 Feb 02; 10. PMID: 33522486    Free PMC article.
Epigenetic Alterations in the Gastrointestinal Tract: Current and Emerging Use for Biomarkers of Cancer.
William M Grady, Ming Yu, Sanford D Markowitz.
Gastroenterology, 2020 Dec 07; 160(3). PMID: 33279516    Free PMC article.
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Epigenetic Alterations in Triple-Negative Breast Cancer-The Critical Role of Extracellular Matrix.
Vasiliki Zolota, Vasiliki Tzelepi, +4 authors, Nikos K Karamanos.
Cancers (Basel), 2021 Feb 13; 13(4). PMID: 33572395    Free PMC article.
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Systemic Lupus Erythematosus in Children and Young People.
A Charras, E Smith, C M Hedrich.
Curr Rheumatol Rep, 2021 Feb 12; 23(3). PMID: 33569643    Free PMC article.
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Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines.
Suleyman Vural, Alida Palmisano, +3 authors, Julia Krushkal.
Clin Epigenetics, 2021 Mar 08; 13(1). PMID: 33676569    Free PMC article.
Downregulation of lncRNA ZNF582-AS1 due to DNA hypermethylation promotes clear cell renal cell carcinoma growth and metastasis by regulating the N(6)-methyladenosine modification of MT-RNR1.
Wuping Yang, Kenan Zhang, +7 authors, Kan Gong.
J Exp Clin Cancer Res, 2021 Mar 12; 40(1). PMID: 33691743    Free PMC article.
Loss of 5-Hydroxymethylcytosine as an Epigenetic Signature That Correlates With Poor Outcomes in Patients With Medulloblastoma.
Fu Zhao, Zhi-Wei Zhang, +9 authors, Pinan Liu.
Front Oncol, 2021 Mar 16; 11. PMID: 33718152    Free PMC article.
Integrated multi-omics analysis of ovarian cancer using variational autoencoders.
Muta Tah Hira, M A Razzaque, +3 authors, Mosharraf Sarkar.
Sci Rep, 2021 Mar 20; 11(1). PMID: 33737557    Free PMC article.
CENP-A overexpression promotes distinct fates in human cells, depending on p53 status.
Daniel Jeffery, Alberto Gatto, +6 authors, Geneviève Almouzni.
Commun Biol, 2021 Mar 28; 4(1). PMID: 33772115    Free PMC article.
Prognostic significance of epigenetic regulatory gene expression in patients with non-small-cell lung cancer.
Zegui Tu, Xiancheng Chen, +2 authors, Meijuan Huang.
Aging (Albany NY), 2021 Mar 05; 13(5). PMID: 33658396    Free PMC article.
Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup.
Felix K F Kommoss, Damian Stichel, +13 authors, Christian Koelsche.
Mod Pathol, 2021 Apr 14;. PMID: 33846547
Identification and validation of the clinical roles of the VHL-related LncRNAs in clear cell renal cell carcinoma.
Wuping Yang, Jingcheng Zhou, +7 authors, Kan Gong.
J Cancer, 2021 Apr 16; 12(9). PMID: 33854630    Free PMC article.
Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis.
Michael A Koldobskiy, Garrett Jenkinson, +12 authors, Andrew P Feinberg.
Nat Biomed Eng, 2021 Apr 17; 5(4). PMID: 33859388
Clinical evaluation of Bladder CARE, a new epigenetic test for bladder cancer detection in urine samples.
Paolo Piatti, Yap Ching Chew, +13 authors, Gangning Liang.
Clin Epigenetics, 2021 Apr 23; 13(1). PMID: 33882992    Free PMC article.
Interplay between genetic, epigenetic, and gene expression variability: Considering complexity in evolvability.
Jean-Pascal Capp.
Evol Appl, 2021 Apr 27; 14(4). PMID: 33897810    Free PMC article.
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Role of Chromodomain-Helicase-DNA-Binding Protein 4 (CHD4) in Breast Cancer.
Apolonia Novillo, Ana Fernández-Santander, +4 authors, Pablo Gómez-Del Arco.
Front Oncol, 2021 May 14; 11. PMID: 33981601    Free PMC article.
The impact of epigenetic information on genome evolution.
Soojin V Yi, Michael A D Goodisman.
Philos Trans R Soc Lond B Biol Sci, 2021 Apr 20; 376(1826). PMID: 33866804    Free PMC article.
CHD4 as an important mediator in regulating the malignant behaviors of colorectal cancer.
Chia-Lo Chang, Chi-Ruei Huang, +4 authors, Hon-Kan Yip.
Int J Biol Sci, 2021 May 18; 17(7). PMID: 33994851    Free PMC article.
Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis.
Jennifer A Karlow, Benpeng Miao, +2 authors, Bo Zhang.
Commun Biol, 2021 May 23; 4(1). PMID: 34021236    Free PMC article.
Cyclic DNA remethylation following active demethylation at euchromatic regions in mouse embryonic stem cells.
Musashi Kubiura-Ichimaru, Takamasa Ito, Louis Lefebvre, Masako Tada.
Chromosome Res, 2020 Nov 19; 29(2). PMID: 33205231
Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation.
Alireza Lorzadeh, Maile Romero-Wolf, Ajay Goel, Unmesh Jadhav.
Gastroenterology, 2021 Mar 30; 160(7). PMID: 33775639    Free PMC article.
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Personalized Medicine for Neuroblastoma: Moving from Static Genotypes to Dynamic Simulations of Drug Response.
Jeremy Z R Han, Jordan F Hastings, +3 authors, David R Croucher.
J Pers Med, 2021 Jun 03; 11(5). PMID: 34064704    Free PMC article.
Review.