Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

Tyler R Simpson ¹, Fubin Li , Welby Montalvo-Ortiz , Manuel A Sepulveda , Katharina Bergerhoff , Frederick Arce , Claire Roddie , Jake Y Henry , Hideo Yagita , Jedd D Wolchok , Karl S Peggs , Jeffrey V Ravetch , James P Allison , Sergio A Quezada

Affiliations

¹ Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 23897981
60 References
603 citations

Abstract

Treatment with monoclonal antibody specific for cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, has emerged as an effective therapy for the treatment of metastatic melanoma. Although subject to debate, current models favor a mechanism of activity involving blockade of the inhibitory activity of CTLA-4 on both effector (T eff) and regulatory (T reg) T cells, resulting in enhanced antitumor effector T cell activity capable of inducing tumor regression. We demonstrate, however, that the activity of anti-CTLA-4 antibody on the T reg cell compartment is mediated via selective depletion of T reg cells within tumor lesions. Importantly, T reg cell depletion is dependent on the presence of Fcγ receptor-expressing macrophages within the tumor microenvironment, indicating that T reg cells are depleted in trans in a context-dependent manner. Our results reveal further mechanistic insight into the activity of anti-CTLA-4-based cancer immunotherapy, and illustrate the importance of specific features of the local tumor environment on the final outcome of antibody-based immunomodulatory therapies.

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Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma. Rafael Winograd, Katelyn T Byrne, +8 authors, Robert H Vonderheide. less Cancer Immunol Res, 2015 Feb 14; 3(4). PMID: 25678581 Free PMC article. Highly Cited.
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Targeting the tumor microenvironment to enhance antitumor immune responses. Kevin Van der Jeught, Lukasz Bialkowski, +7 authors, Karine Breckpot. less Oncotarget, 2015 Feb 16; 6(3). PMID: 25682197 Free PMC article. Review.
Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair. Dietmar M W Zaiss, William C Gause, Lisa C Osborne, David Artis. Immunity, 2015 Feb 19; 42(2). PMID: 25692699 Free PMC article. Highly Cited. Review.
The interaction of anticancer therapies with tumor-associated macrophages. Alberto Mantovani, Paola Allavena. J Exp Med, 2015 Mar 11; 212(4). PMID: 25753580 Free PMC article. Highly Cited. Review.
Haematological malignancies: at the forefront of immunotherapeutic innovation. Pavan Bachireddy, Ute E Burkhardt, Mohini Rajasagi, Catherine J Wu. Nat Rev Cancer, 2015 Mar 20; 15(4). PMID: 25786696 Free PMC article. Review.
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma. Kathleen M Mahoney, Gordon J Freeman, David F McDermott. Clin Ther, 2015 Apr 01; 37(4). PMID: 25823918 Free PMC article. Highly Cited. Review.
CTLA-4⁺ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis. Hyun-Bae Jie, Patrick J Schuler, +5 authors, Robert L Ferris. less Cancer Res, 2015 Apr 03; 75(11). PMID: 25832655 Free PMC article. Highly Cited.
Immunotherapy in Cancer: A Combat between Tumors and the Immune System; You Win Some, You Lose Some. Florencia Paula Madorsky Rowdo, Antonela Baron, Mariela Urrutia, José Mordoh. Front Immunol, 2015 Apr 11; 6. PMID: 25859247 Free PMC article. Review.
Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Camille Guillerey, Lucas Ferrari de Andrade, +12 authors, Ludovic Martinet. less J Clin Invest, 2015 Apr 22; 125(5). PMID: 25893601 Free PMC article.
Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis. Haiming Yu, Junlan Yang, +3 authors, Shunchang Jiao, Ying Li, Wei Zhang, Jiandong Wang. less Cancer Immunol Immunother, 2015 Apr 22; 64(7). PMID: 25893809 Free PMC article.
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. Emanuela Romano, Monika Kusio-Kobialka, +7 authors, Daniel E Speiser. less Proc Natl Acad Sci U S A, 2015 Apr 29; 112(19). PMID: 25918390 Free PMC article. Highly Cited.
OECI-EACR precision medicine for cancer: Conference report 1-4 March 2015, Luxembourg. Anna Golebiewska, Sabrina Fritah, Maria Romina Girotti. Ecancermedicalscience, 2015 May 02; 9. PMID: 25932043 Free PMC article.
An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions. Michelle Kinder, Allison R Greenplate, +2 authors, William R Strohl, Robert E Jordan, Randall J Brezski. less MAbs, 2015 May 02; 7(3). PMID: 25933349 Free PMC article.
Brucella spp. Lumazine Synthase Induces a TLR4-Mediated Protective Response against B16 Melanoma in Mice. Andrés H Rossi, Ana Farias, +3 authors, Paula M Berguer. less PLoS One, 2015 May 15; 10(5). PMID: 25973756 Free PMC article.
Rapid complete response of metastatic melanoma in a patient undergoing ipilimumab immunotherapy in the setting of active ulcerative colitis. A Doran Bostwick, April K Salama, Brent A Hanks. J Immunother Cancer, 2015 May 21; 3. PMID: 25992290 Free PMC article.
Inhibitory receptors as targets for cancer immunotherapy. Meghan E Turnis, Lawrence P Andrews, Dario A A Vignali. Eur J Immunol, 2015 May 29; 45(7). PMID: 26018646 Free PMC article. Review.
Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Alice O Kamphorst, Koichi Araki, Rafi Ahmed. Vaccine, 2015 May 30; 33 Suppl 2. PMID: 26022562 Free PMC article. Review.
In-situ tumor vaccination: Bringing the fight to the tumor. Robert H Pierce, Jean S Campbell, +2 authors, Sara I Pai, Joshua D Brody, Holbrook E K Kohrt. less Hum Vaccin Immunother, 2015 Jun 10; 11(8). PMID: 26055074 Free PMC article. Review.
Immune-mediated adverse events of anticytotoxic T lymphocyte-associated antigen 4 antibody therapy in metastatic melanoma. Shannon K Quirk, Anna K Shure, Devendra K Agrawal. Transl Res, 2015 Jun 30; 166(5). PMID: 26118951 Free PMC article. Review.
In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment. Claire Vanpouille-Box, Karsten A Pilones, +2 authors, Erik Wennerberg, Silvia C Formenti, Sandra Demaria. less Vaccine, 2015 Jul 08; 33(51). PMID: 26148880 Free PMC article. Review.
Clinical Development of Immune Checkpoint Inhibitors. Ayumu Ito, Shunsuke Kondo, Kohei Tada, Shigehisa Kitano. Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161407 Free PMC article. Review.
Inhibitory Receptors Beyond T Cell Exhaustion. Silvia A Fuertes Marraco, Natalie J Neubert, Grégory Verdeil, Daniel E Speiser. Front Immunol, 2015 Jul 15; 6. PMID: 26167163 Free PMC article. Highly Cited. Review.
Evolving synergistic combinations of targeted immunotherapies to combat cancer. Ignacio Melero, David M Berman, +3 authors, John Haanen. less Nat Rev Cancer, 2015 Jul 25; 15(8). PMID: 26205340 Highly Cited. Review.
Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment. J David Peske, Amber B Woods, Victor H Engelhard. Adv Cancer Res, 2015 Jul 29; 128. PMID: 26216636 Free PMC article. Review.
Combination cancer immunotherapy and new immunomodulatory targets. Kathleen M Mahoney, Paul D Rennert, Gordon J Freeman. Nat Rev Drug Discov, 2015 Aug 01; 14(8). PMID: 26228759 Highly Cited. Review.
Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors. Francesca De Felice, Claudia Marchetti, +4 authors, Pierluigi Benedetti Panici. less J Immunol Res, 2015 Aug 04; 2015. PMID: 26236750 Free PMC article. Review.
Relevance of tumor-infiltrating lymphocytes in breast cancer. Sathana Dushyanthen, Paul A Beavis, +5 authors, Sherene Loi. less BMC Med, 2015 Aug 25; 13. PMID: 26300242 Free PMC article. Highly Cited. Review.
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. Chih-Hao Chang, Jing Qiu, +11 authors, Erika L Pearce. less Cell, 2015 Sep 01; 162(6). PMID: 26321679 Free PMC article. Highly Cited.
Co-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells? Simon Ville, Nicolas Poirier, Gilles Blancho, Bernard Vanhove. Front Immunol, 2015 Sep 01; 6. PMID: 26322044 Free PMC article. Review.
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade. Elizabeth Buchbinder, F Stephen Hodi. J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325034 Free PMC article. Review.
Increased expression of immunosuppressive molecules on intratumoral and circulating regulatory T cells in non-small-cell lung cancer patients. Tengfei Wei, Jun Zhang, +5 authors, Qian Shen. less Am J Cancer Res, 2015 Sep 04; 5(7). PMID: 26328249 Free PMC article.
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. Anne Bertrand, Marie Kostine, +2 authors, Thierry Schaeverbeke. less BMC Med, 2015 Sep 05; 13. PMID: 26337719 Free PMC article. Highly Cited. Systematic Review.
Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses. Nikhil S Joshi, Elliot H Akama-Garren, +11 authors, Tyler Jacks. less Immunity, 2015 Sep 06; 43(3). PMID: 26341400 Free PMC article. Highly Cited.
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine. Todd Bartkowiak, Shailbala Singh, +6 authors, Michael A Curran. less Proc Natl Acad Sci U S A, 2015 Sep 10; 112(38). PMID: 26351680 Free PMC article.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. Alison M Paterson, Scott B Lovitch, +9 authors, Arlene H Sharpe. less J Exp Med, 2015 Sep 16; 212(10). PMID: 26371185 Free PMC article. Highly Cited.
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity. Alan Serrels, Tom Lund, +15 authors, Margaret C Frame. less Cell, 2015 Sep 26; 163(1). PMID: 26406376 Free PMC article. Highly Cited.
Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma. N Yamazaki, H Uhara, +8 authors, T Tokudome. less Cancer Chemother Pharmacol, 2015 Sep 27; 76(5). PMID: 26407818 Free PMC article.
Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma. N Yamazaki, Y Kiyohara, +8 authors, T Tokudome. less Cancer Chemother Pharmacol, 2015 Sep 28; 76(5). PMID: 26410424 Free PMC article.
TIGIT predominantly regulates the immune response via regulatory T cells. Sema Kurtulus, Kaori Sakuishi, +6 authors, Ana C Anderson. less J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413872 Free PMC article. Highly Cited.
Targeting the tumor niche to treat cancer. Sattva S Neelapu, Padmanee Sharma. Proc Natl Acad Sci U S A, 2015 Oct 10; 112(42). PMID: 26450879 Free PMC article.
Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy. Kelly Kersten, Camilla Salvagno, Karin E de Visser. Front Immunol, 2015 Oct 27; 6. PMID: 26500653 Free PMC article. Review.
Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy. David A Reardon, Mark R Gilbert, Wolfgang Wick, Linda Liau. Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516225 Free PMC article. Review.
Cancer immunotherapy: Strategies for personalization and combinatorial approaches. Vishwanath Sathyanarayanan, Sattva S Neelapu. Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548534 Free PMC article. Review.
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy. Anna Śledzińska, Laurie Menger, +2 authors, Katharina Bergerhoff, Karl S Peggs, Sergio A Quezada. less Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578451 Free PMC article. Review.
Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy. Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong. J Immunol Res, 2015 Nov 19; 2015. PMID: 26579545 Free PMC article. Review.
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. Roy L Maute, Sydney R Gordon, +10 authors, Aaron M Ring. less Proc Natl Acad Sci U S A, 2015 Nov 26; 112(47). PMID: 26604307 Free PMC article. Highly Cited.
Immune checkpoint inhibitors: therapeutic advances in melanoma. Ivan Márquez-Rodas, Pablo Cerezuela, +4 authors, Salvador Martín-Algarra. less Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605313 Free PMC article. Review.
Melanoma: oncogenic drivers and the immune system. Niki Karachaliou, Sara Pilotto, +10 authors, Rafael Rosell. less Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605311 Free PMC article. Review.
Immune suppressive mechanisms in the tumor microenvironment. David H Munn, Vincenzo Bronte. Curr Opin Immunol, 2015 Nov 27; 39. PMID: 26609943 Free PMC article. Highly Cited. Review.
Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics. Mohammad Rashidian, Lu Wang, +7 authors, Steven H Liang. less Angew Chem Int Ed Engl, 2015 Dec 03; 55(2). PMID: 26630549 Free PMC article.
Vaccines Combined with Immune Checkpoint Antibodies Promote Cytotoxic T-cell Activity and Tumor Eradication. Omar A Ali, Sarah A Lewin, Glenn Dranoff, David J Mooney. Cancer Immunol Res, 2015 Dec 17; 4(2). PMID: 26669718 Free PMC article.
Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells. Stephanie Vogel, Elena Grabski, +12 authors, Ulrich Kalinke. less Sci Rep, 2015 Dec 17; 5. PMID: 26670584 Free PMC article.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy. Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake. Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632 Free PMC article. Review.
Influence of immunoglobulin isotype on therapeutic antibody function. Stephen A Beers, Martin J Glennie, Ann L White. Blood, 2016 Jan 15; 127(9). PMID: 26764357 Free PMC article. Review.
Novel technologies and emerging biomarkers for personalized cancer immunotherapy. Jianda Yuan, Priti S Hegde, +16 authors, Bernard A Fox. less J Immunother Cancer, 2016 Jan 21; 4. PMID: 26788324 Free PMC article. Highly Cited. Review.
The role of microbiota in cancer therapy. Ernesto Perez-Chanona, Giorgio Trinchieri. Curr Opin Immunol, 2016 Jan 29; 39. PMID: 26820225 Free PMC article. Review.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella. Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028 Free PMC article. Review.
Ipilimumab (Anti-Ctla-4 Mab) in the treatment of metastatic melanoma: Effectiveness and toxicity management. Paola Savoia, Chiara Astrua, Paolo Fava. Hum Vaccin Immunother, 2016 Feb 19; 12(5). PMID: 26889818 Free PMC article. Review.
Blocking immune checkpoints in prostate, kidney, and urothelial cancer: An overview. Angela K B Alme, Beerinder S Karir, Bishoy M Faltas, Charles G Drake. Urol Oncol, 2016 Mar 01; 34(4). PMID: 26923782 Free PMC article. Review.
T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway. Jose-Ignacio Rodriguez-Barbosa, Carlos Fernandez-Renedo, +2 authors, Ana María Bravo Moral, Leo Bühler, Maria-Luisa Del Rio. less Cell Mol Immunol, 2016 Mar 01; 14(6). PMID: 26924526 Free PMC article.
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Weiping Zou, Jedd D Wolchok, Lieping Chen. Sci Transl Med, 2016 Mar 05; 8(328). PMID: 26936508 Free PMC article. Highly Cited. Review.
Tumor-associated macrophages and anti-tumor therapies: complex links. Cristina Belgiovine, Maurizio D'Incalci, Paola Allavena, Roberta Frapolli. Cell Mol Life Sci, 2016 Mar 10; 73(13). PMID: 26956893 Review.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok. Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780 Free PMC article. Highly Cited. Review.
Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7. Matthew M Halpert, Vanaja Konduri, +5 authors, William K Decker. less Stem Cells Dev, 2016 Mar 17; 25(10). PMID: 26979751 Free PMC article.
T cell receptor signalling in the control of regulatory T cell differentiation and function. Ming O Li, Alexander Y Rudensky. Nat Rev Immunol, 2016 Mar 31; 16(4). PMID: 27026074 Free PMC article. Highly Cited. Review.
OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential. Chester Lai, Suzannah August, +9 authors, Eugene Healy. less Clin Cancer Res, 2016 Apr 02; 22(16). PMID: 27034329 Free PMC article.
Tremelimumab: research and clinical development. Begoña Comin-Anduix, Helena Escuin-Ordinas, Francisco Javier Ibarrondo. Onco Targets Ther, 2016 Apr 05; 9. PMID: 27042127 Free PMC article. Review.
Emerging Opportunities and Challenges in Cancer Immunotherapy. Theresa L Whiteside, Sandra Demaria, +2 authors, Ignacio Melero. less Clin Cancer Res, 2016 Apr 17; 22(8). PMID: 27084738 Free PMC article. Highly Cited. Review.
Reversing T-cell Dysfunction and Exhaustion in Cancer. Hassane M Zarour. Clin Cancer Res, 2016 Apr 17; 22(8). PMID: 27084739 Free PMC article. Highly Cited. Review.
Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model. De-Kuan Chang, Eric Peterson, +6 authors, Wayne A Marasco. less Oncoimmunology, 2016 May 04; 5(3). PMID: 27141347 Free PMC article.
Targeting immunosuppression by Tregs with monoclonal antibodies against GARP. Stéphanie Liénart, Julie Stockis, Olivier Dedobbeleer, Sophie Lucas. Oncoimmunology, 2016 May 04; 5(3). PMID: 27141368 Free PMC article.
Roles of regulatory T cells in cancer immunity. Yoshiko Takeuchi, Hiroyoshi Nishikawa. Int Immunol, 2016 May 11; 28(8). PMID: 27160722 Free PMC article. Highly Cited. Review.
Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity. Hidetoshi Nakagawa, Jessica M Sido, +3 authors, Hye-Jung Kim. less Proc Natl Acad Sci U S A, 2016 May 18; 113(22). PMID: 27185917 Free PMC article.
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. Mira A Patel, Jennifer E Kim, +19 authors, Michael Lim. less J Immunother Cancer, 2016 May 18; 4. PMID: 27190629 Free PMC article.
Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection? Lucia Festino, Gerardo Botti, +5 authors, Paolo A Ascierto. less Drugs, 2016 May 28; 76(9). PMID: 27229745 Highly Cited. Review.
Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement. Rony Dahan, Bryan C Barnhart, +3 authors, Jeffrey V Ravetch. less Cancer Cell, 2016 Jun 07; 29(6). PMID: 27265505 Free PMC article. Highly Cited.
Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy. Kristina H Young, Jason R Baird, +9 authors, Marka R Crittenden. less PLoS One, 2016 Jun 10; 11(6). PMID: 27281029 Free PMC article. Highly Cited.
Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade. Michal Lotem, Sharon Merims, +19 authors, Tamar Peretz. less J Immunol Res, 2016 Jun 14; 2016. PMID: 27294163 Free PMC article.
Enhancement of Immune Effector Functions by Modulating IgG's Intrinsic Affinity for Target Antigen. Yariv Mazor, Chunning Yang, +4 authors, William F Dall'Acqua. less PLoS One, 2016 Jun 21; 11(6). PMID: 27322177 Free PMC article.
The role of myeloid cells in cancer therapies. Camilla Engblom, Christina Pfirschke, Mikael J Pittet. Nat Rev Cancer, 2016 Jun 25; 16(7). PMID: 27339708 Highly Cited. Review.
CTLA-4 Limits Anti-CD20-Mediated Tumor Regression. Zhenhua Ren, Jingya Guo, +7 authors, Yang-Xin Fu. less Clin Cancer Res, 2016 Jun 30; 23(1). PMID: 27354469 Free PMC article.
CIMT 2016: Mechanisms of efficacy in cancer immunotherapy - Report on the 14th Annual Meeting of the Association for Cancer Immunotherapy May 10-12 2016, Mainz, Germany. Lena M Kranz, Matthias Birtel, +7 authors, Mustafa Diken. less Hum Vaccin Immunother, 2016 Jul 21; 12(11). PMID: 27435168 Free PMC article.
Immuno-oncology combinations: raising the tail of the survival curve. Samuel J Harris, Jessica Brown, Juanita Lopez, Timothy A Yap. Cancer Biol Med, 2016 Jul 28; 13(2). PMID: 27458526 Free PMC article.
CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma. Guang-Tao Yu, Lin-Lin Bu, +5 authors, Zhi-Jun Sun. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471622 Free PMC article.
SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade. Wei Xue, Rachael L Metheringham, +5 authors, Lindy G Durrant. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471648 Free PMC article.
CD28 co-stimulation in T-cell homeostasis: a recent perspective. Niklas Beyersdorf, Thomas Kerkau, Thomas Hünig. Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471717 Free PMC article. Review.
Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients. Teofila Seremet, Alexander Koch, +12 authors, Bart Neyns. less J Transl Med, 2016 Aug 04; 14(1). PMID: 27484791 Free PMC article.
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy. Lewis Zhichang Shi, Tihui Fu, +7 authors, Padmanee Sharma. less Nat Commun, 2016 Aug 09; 7. PMID: 27498556 Free PMC article.
Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ. Amy E Moran, Fanny Polesso, Andrew D Weinberg. J Immunol, 2016 Aug 10; 197(6). PMID: 27503208 Free PMC article.
A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma. Todd Crocenzi, Benjamin Cottam, +12 authors, Marka R Crittenden. less J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532020 Free PMC article.
A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling. Heather L McArthur, Adi Diab, +27 authors, Larry Norton. less Clin Cancer Res, 2016 Nov 05; 22(23). PMID: 27566765 Free PMC article.
Forced co-expression of IL-21 and IL-7 in whole-cell cancer vaccines promotes antitumor immunity. Yang-Zhuo Gu, Chuan-Wen Fan, +7 authors, Yu-Quan Wei. less Sci Rep, 2016 Aug 31; 6. PMID: 27571893 Free PMC article.
Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy. David B Page, Jianda Yuan, +22 authors, Heather L McArthur. less Cancer Immunol Res, 2016 Sep 03; 4(10). PMID: 27587469 Free PMC article.
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology. Mark J Selby, John J Engelhardt, +11 authors, Alan J Korman. less PLoS One, 2016 Sep 10; 11(9). PMID: 27610613 Free PMC article. Highly Cited.
Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop. Roch Houot, Philippe Gaulard, +18 authors, Daniel Olive. less Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622041 Free PMC article.
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy. Geoffrey S Williams, Bina Mistry, +20 authors, Robert W Wilkinson. less Oncotarget, 2016 Sep 15; 7(42). PMID: 27626702 Free PMC article.
Current clinical trials testing the combination of immunotherapy with radiotherapy. Josephine Kang, Sandra Demaria, Silvia Formenti. J Immunother Cancer, 2016 Sep 24; 4. PMID: 27660705 Free PMC article. Highly Cited.
Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer. Grit S Herter-Sprie, Shohei Koyama, +18 authors, Kwok-Kin Wong. less JCI Insight, 2016 Oct 05; 1(9). PMID: 27699275 Free PMC article.
Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation. Peter Ellmark, Sara M Mangsbo, +2 authors, Christina Furebring, Per Norlén, Thomas H Tötterman. less Cancer Immunol Immunother, 2016 Oct 08; 66(1). PMID: 27714433 Free PMC article. Review.
Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together. Gareth W Jones, David G Hill, Simon A Jones. Front Immunol, 2016 Oct 19; 7. PMID: 27752256 Free PMC article. Review.
Evaluation of immune infiltration in the colonic mucosa of patients with ipilimumab-related colitis. Edurne Arriola, Matthew Wheater, +2 authors, Maria Antonette Lopez, Gareth Thomas, Christian Ottensmeier. less Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757302 Free PMC article.
The head and neck cancer immune landscape and its immunotherapeutic implications. Rajarsi Mandal, Yasin Şenbabaoğlu, +8 authors, Luc Gt Morris. less JCI Insight, 2016 Oct 26; 1(17). PMID: 27777979 Free PMC article. Highly Cited.
Recent advances in understanding antitumor immunity. Rodrigo Ramella Munhoz, Michael Andrew Postow. F1000Res, 2016 Nov 03; 5. PMID: 27803807 Free PMC article. Review.
Is There Still Room for Cancer Vaccines at the Era of Checkpoint Inhibitors. Soumaya Karaki, Marie Anson, +4 authors, Eric Tartour. less Vaccines (Basel), 2016 Nov 10; 4(4). PMID: 27827885 Free PMC article. Review.
Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells. Marco De Simone, Alberto Arrigoni, +28 authors, Massimiliano Pagani. less Immunity, 2016 Nov 17; 45(5). PMID: 27851914 Free PMC article. Highly Cited.
Immune checkpoint therapy for pancreatic cancer. Henrik Johansson, Roland Andersson, +3 authors, Daniel Ansari. less World J Gastroenterol, 2016 Dec 07; 22(43). PMID: 27920468 Free PMC article. Review.
Role of Fc-FcγR interactions in the antitumor activity of therapeutic antibodies. Bryan C Barnhart, Michael Quigley. Immunol Cell Biol, 2016 Dec 16; 95(4). PMID: 27974746 Review.
Regulatory T cells in cancer immunotherapy. Atsushi Tanaka, Shimon Sakaguchi. Cell Res, 2016 Dec 21; 27(1). PMID: 27995907 Free PMC article. Highly Cited. Review.
A New VISTA on combination therapy for negative checkpoint regulator blockade. Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J Noelle. J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031817 Free PMC article. Review.
TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis. Michael P Holt, George A Punkosdy, Deborah D Glass, Ethan M Shevach. J Immunol, 2017 Jan 06; 198(4). PMID: 28053234 Free PMC article.
Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity. W Joost Lesterhuis, Anthony Bosco, +3 authors, Richard A Lake. less Nat Rev Drug Discov, 2017 Jan 07; 16(4). PMID: 28057932 Highly Cited. Review.
Effective Combination of Innate and Adaptive Immunotherapeutic Approaches in a Mouse Melanoma Model. Alexander L Rakhmilevich, Mildred Felder, +8 authors, Paul M Sondel. less J Immunol, 2017 Jan 08; 198(4). PMID: 28062694 Free PMC article.
New Immunotherapy Strategies in Breast Cancer. Lin-Yu Yu, Jie Tang, +4 authors, Xiao-Ping Chen. less Int J Environ Res Public Health, 2017 Jan 14; 14(1). PMID: 28085094 Free PMC article. Review.
Systemic Immunity Is Required for Effective Cancer Immunotherapy. Matthew H Spitzer, Yaron Carmi, +10 authors, Edgar G Engleman. less Cell, 2017 Jan 24; 168(3). PMID: 28111070 Free PMC article. Highly Cited.
Tumour-associated macrophages as treatment targets in oncology. Alberto Mantovani, Federica Marchesi, +2 authors, Alberto Malesci, Luigi Laghi, Paola Allavena. less Nat Rev Clin Oncol, 2017 Jan 25; 14(7). PMID: 28117416 Free PMC article. Highly Cited. Review.
Frequency of regulatory T cells determines the outcome of the T-cell-engaging antibody blinatumomab in patients with B-precursor ALL. J Duell, M Dittrich, +8 authors, M S Topp. less Leukemia, 2017 Jan 26; 31(10). PMID: 28119525 Free PMC article. Highly Cited.
Antibody-dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells. Maria Carmen Ochoa, Luna Minute, +5 authors, Pedro Berraondo. less Immunol Cell Biol, 2017 Feb 01; 95(4). PMID: 28138156 Highly Cited. Review.
Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma. Antonio Miguel, Luis Sendra, +5 authors, Salvador F Aliño. less Onco Targets Ther, 2017 Feb 09; 10. PMID: 28176947 Free PMC article.
Next steps in immuno-oncology: enhancing antitumor effects through appropriate patient selection and rationally designed combination strategies. A K S Salama, S J Moschos. Ann Oncol, 2017 Feb 09; 28(1). PMID: 28177433 Free PMC article. Review.
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy. Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas. Cell, 2017 Feb 12; 168(4). PMID: 28187290 Free PMC article. Highly Cited. Review.
Cbx3/HP1γ deficiency confers enhanced tumor-killing capacity on CD8+ T cells. Michael Sun, Ngoc Ha, +7 authors, To-Ha Thai. less Sci Rep, 2017 Feb 22; 7. PMID: 28220815 Free PMC article.
Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1. Anchana Rathinasamy, Christoph Domschke, +10 authors, Philipp Beckhove. less Cancer Immunol Immunother, 2017 Feb 23; 66(5). PMID: 28224210 Free PMC article.
The Unique Molecular and Cellular Microenvironment of Ovarian Cancer. Thomas Worzfeld, Elke Pogge von Strandmann, +4 authors, Rolf Müller. less Front Oncol, 2017 Mar 10; 7. PMID: 28275576 Free PMC article. Highly Cited. Review.
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients. Rossana Tallerico, Costanza M Cristiani, +21 authors, Ennio Carbone. less Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344869 Free PMC article.
Cancer Immunotherapy: Whence and Whither. Peter J Stambrook, John Maher, Farzin Farzaneh. Mol Cancer Res, 2017 Mar 31; 15(6). PMID: 28356330 Free PMC article. Review.
Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms. Kirstie L S Cleary, H T Claude Chan, +2 authors, Sonja James, Martin J Glennie, Mark S Cragg. less J Immunol, 2017 Apr 14; 198(10). PMID: 28404636 Free PMC article.
Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer. Xiaowei Chen, Yoshihiro Takemoto, +9 authors, Timothy C Wang. less Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405523 Free PMC article.
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors. Frederick Arce Vargas, Andrew J S Furness, +29 authors, Sergio A Quezada. less Immunity, 2017 Apr 16; 46(4). PMID: 28410988 Free PMC article. Highly Cited.
Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma. Yago Pico de Coaña, Maria Wolodarski, +9 authors, Rolf Kiessling. less Oncotarget, 2017 Apr 21; 8(13). PMID: 28423487 Free PMC article.
Role of modern immunotherapy in gastrointestinal malignancies: a review of current clinical progress. Zin W Myint, Gaurav Goel. J Hematol Oncol, 2017 Apr 25; 10(1). PMID: 28434400 Free PMC article. Review.
Signaling by Antibodies: Recent Progress. Stylianos Bournazos, Taia T Wang, +2 authors, Rony Dahan, Jad Maamary, Jeffrey V Ravetch. less Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446061 Free PMC article. Highly Cited. Review.
Simultaneous exposure to FcγR and FcαR on monocytes and macrophages enhances antitumor activity in vivo. Bingyu Li, Lijun Xu, +10 authors, Jianmin Fang. less Oncotarget, 2017 Apr 30; 8(24). PMID: 28454118 Free PMC article.
Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab. Udupi A Ramagopal, Weifeng Liu, +10 authors, Steven C Almo. less Proc Natl Acad Sci U S A, 2017 May 10; 114(21). PMID: 28484017 Free PMC article.
Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells. Rodrigo Vazquez-Lombardi, Claudia Loetsch, +8 authors, Daniel Christ. less Nat Commun, 2017 May 13; 8. PMID: 28497796 Free PMC article.
B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment. Giulia Chiaruttini, Silvia Mele, +4 authors, Sophia N Karagiannis. less Oncoimmunology, 2017 May 17; 6(4). PMID: 28507802 Free PMC article. Review.
Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease. Andrew S Flies, Nicholas B Blackburn, +2 authors, Alan Bruce Lyons, John D Hayball, Gregory M Woods. less Front Immunol, 2017 May 19; 8. PMID: 28515726 Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses. Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee. less Oncotarget, 2017 May 26; 8(29). PMID: 28537894 Free PMC article.
Combining radiotherapy with immunotherapy: the past, the present and the future. Evert J Van Limbergen, Dirk K De Ruysscher, +8 authors, Philippe Lambin. less Br J Radiol, 2017 May 26; 90(1076). PMID: 28541096 Free PMC article. Review.
Delivering safer immunotherapies for cancer. Lauren Milling, Yuan Zhang, Darrell J Irvine. Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888 Free PMC article. Highly Cited. Review.
Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy. Jingyu Zhang, Dai Liu, +4 authors, Jennifer D Wu. less Sci Adv, 2017 Jun 01; 3(5). PMID: 28560327 Free PMC article.
PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells. Carmen Stecher, Claire Battin, +5 authors, Peter Steinberger. less Front Immunol, 2017 Jun 08; 8. PMID: 28588576 Free PMC article.
Immune Checkpoints as a Target for Colorectal Cancer Treatment. Alessandro Passardi, Matteo Canale, Martina Valgiusti, Paola Ulivi. Int J Mol Sci, 2017 Jun 22; 18(6). PMID: 28635639 Free PMC article. Review.
Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases. Dipti Vijayan, Deborah S Barkauskas, +7 authors, Mark J Smyth. less Oncoimmunology, 2017 Jun 24; 6(5). PMID: 28638737 Free PMC article.
Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity. Maher G Nawaf, Maria H Ulvmar, +7 authors, Peter J L Lane. less J Immunol, 2017 Jun 25; 199(3). PMID: 28646041 Free PMC article.
Intratumoral STING Activation with T-cell Checkpoint Modulation Generates Systemic Antitumor Immunity. Casey R Ager, Matthew J Reilley, +3 authors, Michael A Curran. less Cancer Immunol Res, 2017 Jul 05; 5(8). PMID: 28674082 Free PMC article. Highly Cited.
Chemotherapy and tumor microenvironment of pancreatic cancer. Qiaofei Liu, Quan Liao, Yupei Zhao. Cancer Cell Int, 2017 Jul 12; 17. PMID: 28694739 Free PMC article. Review.
Checkpoint Inhibitors for Non-Small Cell Lung Cancer Among Older Adults. Rawad Elias, Joshua Morales, Carolyn Presley. Curr Oncol Rep, 2017 Jul 30; 19(9). PMID: 28755314 Review.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer. Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour. less ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757 Free PMC article. Highly Cited. Review.
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade. Spencer C Wei, Jacob H Levine, +8 authors, James P Allison. less Cell, 2017 Aug 15; 170(6). PMID: 28803728 Free PMC article. Highly Cited.
Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade. Dipongkor Saha, Robert L Martuza, Samuel D Rabkin. Cancer Cell, 2017 Aug 16; 32(2). PMID: 28810147 Free PMC article. Highly Cited.
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment. Sadna Budhu, David A Schaer, +8 authors, Jedd D Wolchok. less Sci Signal, 2017 Aug 31; 10(494). PMID: 28851824 Free PMC article.
Localized CD47 blockade enhances immunotherapy for murine melanoma. Jessica R Ingram, Olga S Blomberg, +8 authors, Michael Dougan. less Proc Natl Acad Sci U S A, 2017 Sep 07; 114(38). PMID: 28874561 Free PMC article.
Effect of Modified Vaccinia Ankara-5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial. Martin Scurr, Tom Pembroke, +14 authors, Andrew Godkin. less JAMA Oncol, 2017 Sep 08; 3(10). PMID: 28880972 Free PMC article.
PD1 signal transduction pathways in T cells. Hugo Arasanz, Maria Gato-Cañas, +4 authors, David Escors. less Oncotarget, 2017 Sep 09; 8(31). PMID: 28881701 Free PMC article. Highly Cited. Review.
Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells. Paul E Clavijo, Ellen C Moore, +6 authors, Clint T Allen. less Oncotarget, 2017 Sep 17; 8(34). PMID: 28915554 Free PMC article.
EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity. Diana I Albu, Zichun Wang, +15 authors, Xingfeng Bao. less Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28920002 Free PMC article.
Roles for Innate Immunity in Combination Immunotherapies. Kelly D Moynihan, Darrell J Irvine. Cancer Res, 2017 Sep 21; 77(19). PMID: 28928130 Free PMC article. Review.
Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity. Pearl Bakhru, Meng-Lei Zhu, +14 authors, Maureen A Su. less JCI Insight, 2017 Sep 22; 2(18). PMID: 28931755 Free PMC article.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth. Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Michael Saborowski, Florian Kühnel, Norman Woller. less Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503 Free PMC article. Review.
The immune system in cancer metastasis: friend or foe? Louise M E Janssen, Emma E Ramsay, Craig D Logsdon, Willem W Overwijk. J Immunother Cancer, 2017 Oct 19; 5(1). PMID: 29037250 Free PMC article. Highly Cited. Review.
Therapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going? Michael J E Marshall, Richard J Stopforth, Mark S Cragg. Front Immunol, 2017 Oct 20; 8. PMID: 29046676 Free PMC article. Review.
Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells. Shiming Ye, Melvin I Fox, +8 authors, Patricia A Culp. less J Immunol Res, 2017 Oct 28; 2017. PMID: 29075649 Free PMC article.
CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy. Anna Wasiuk, James Testa, +9 authors, Li-Zhen He. less J Immunol, 2017 Nov 08; 199(12). PMID: 29109120 Free PMC article.
Combining DNA damaging therapeutics with immunotherapy: more haste, less speed. Jessica S Brown, Raghav Sundar, Juanita Lopez. Br J Cancer, 2017 Nov 11; 118(3). PMID: 29123260 Free PMC article. Highly Cited. Review.
Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Manisha Singh, Christina Vianden, +15 authors, Willem W Overwijk. less Nat Commun, 2017 Nov 14; 8(1). PMID: 29129918 Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer. R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs. Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554 Free PMC article. Review.
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy. Robert J Torphy, Richard D Schulick, Yuwen Zhu. Int J Mol Sci, 2017 Dec 07; 18(12). PMID: 29211042 Free PMC article. Review.
Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract. Michael Dougan. Front Immunol, 2017 Dec 13; 8. PMID: 29230210 Free PMC article. Highly Cited. Review.
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response? Zijun Y Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H Young. Front Immunol, 2017 Dec 20; 8. PMID: 29255458 Free PMC article. Highly Cited. Review.
The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent. Christopher Bachran, Matthias Schröder, +5 authors, Lee Kim Swee. less Sci Rep, 2017 Dec 22; 7(1). PMID: 29263417 Free PMC article.
Seeing is believing: anti-PD-1/PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy. Shuguang Tan, Catherine W-H Zhang, George F Gao. Signal Transduct Target Ther, 2017 Dec 22; 1. PMID: 29263905 Free PMC article.
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model. Cameron S Field, Martin K Hunn, +3 authors, Ian F Hermans. less Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296535 Free PMC article.
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models. Katherine E Lewis, Mark J Selby, +11 authors, Stacey R Dillon. less Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296539 Free PMC article.
Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy. Neus Martinez-Bosch, Judith Vinaixa, Pilar Navarro. Cancers (Basel), 2018 Jan 06; 10(1). PMID: 29301364 Free PMC article. Highly Cited. Review.
Potential effect of tumor-specific Treg-targeted antibodies in the treatment of human cancers: A bioinformatics analysis. Luigi Cari, Giuseppe Nocentini, Graziella Migliorati, Carlo Riccardi. Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308313 Free PMC article.
Unlocking the Complexities of Tumor-Associated Regulatory T Cells. Jaime L Chao, Peter A Savage. J Immunol, 2018 Jan 10; 200(2). PMID: 29311383 Free PMC article. Review.
Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy. Shivani Srivastava, Stanley R Riddell. J Immunol, 2018 Jan 10; 200(2). PMID: 29311388 Free PMC article. Highly Cited. Review.
Mechanisms of resistance to immune checkpoint inhibitors. Russell W Jenkins, David A Barbie, Keith T Flaherty. Br J Cancer, 2018 Jan 11; 118(1). PMID: 29319049 Free PMC article. Highly Cited. Review.
Regulatory T cells (Tregs): A major immune checkpoint to consider in combinatorial therapeutic HIV-1 vaccines. Audrey Hubert, Nabila Seddiki. Hum Vaccin Immunother, 2018 Jan 31; 14(6). PMID: 29381418 Free PMC article. Review.
Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking. David Taggart, Tereza Andreou, +7 authors, Mihaela Lorger. less Proc Natl Acad Sci U S A, 2018 Feb 02; 115(7). PMID: 29386395 Free PMC article. Highly Cited.
Cancer Immunotherapy: Factors Important for the Evaluation of Safety in Nonclinical Studies. Danuta J Herzyk, Helen G Haggerty. AAPS J, 2018 Feb 09; 20(2). PMID: 29417397 Review.
Tissue-Dependent Tumor Microenvironments and Their Impact on Immunotherapy Responses. Amanda J Oliver, Peter K H Lau, +4 authors, Clare Y Slaney. less Front Immunol, 2018 Feb 16; 9. PMID: 29445373 Free PMC article. Review.
CAR-T cells: the long and winding road to solid tumors. Maria Michela D'Aloia, Ilaria Grazia Zizzari, +2 authors, Benedetto Sacchetti, Luca Pierelli, Maurizio Alimandi. less Cell Death Dis, 2018 Feb 17; 9(3). PMID: 29449531 Free PMC article. Highly Cited. Review.
Exploring the rationale for combining ionizing radiation and immune checkpoint blockade in head and neck cancer. Megan Morisada, Michael Chamberlin, Clint Allen. Head Neck, 2018 Feb 21; 40(6). PMID: 29461655 Free PMC article. Review.
Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice. Xuexiang Du, Mingyue Liu, +8 authors, Pan Zheng. less Cell Res, 2018 Feb 22; 28(4). PMID: 29463898 Free PMC article. Highly Cited.
Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells. Gap Ryol Lee. Mediators Inflamm, 2018 Feb 22; 2017. PMID: 29463952 Free PMC article. Review.
Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis. B L Adler, M K Pezhouh, +15 authors, R A Anders. less J Intern Med, 2018 Feb 22; 283(6). PMID: 29464806 Free PMC article.
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. Xuexiang Du, Fei Tang, +14 authors, Yang Liu. less Cell Res, 2018 Feb 24; 28(4). PMID: 29472691 Free PMC article. Highly Cited.
Checks and Balances in Autoimmune Vasculitis. Rebeca Hid Cadena, Wayel H Abdulahad, +4 authors, Elisabeth Brouwer. less Front Immunol, 2018 Mar 10; 9. PMID: 29520282 Free PMC article. Review.
FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity. Theresa L Whiteside. Expert Opin Ther Targets, 2018 Mar 14; 22(4). PMID: 29532697 Free PMC article. Review.
The Yin and Yang of regulatory T cells in immunotherapy. Yan Li, James P Di Santo. Oncotarget, 2018 Mar 16; 9(13). PMID: 29541377 Free PMC article.
Current status and perspectives in immunotherapy for metastatic melanoma. Riccardo Marconcini, Francesco Spagnolo, +13 authors, Italian Melanoma Intergroup (IMI). less Oncotarget, 2018 Mar 20; 9(15). PMID: 29552325 Free PMC article. Review.
Cancer vaccines: translation from mice to human clinical trials. Hoyoung Maeng, Masaki Terabe, Jay A Berzofsky. Curr Opin Immunol, 2018 Mar 20; 51. PMID: 29554495 Free PMC article. Review.
Current Strategies to Enhance Anti-Tumour Immunity. Katherine W Cook, Lindy G Durrant, Victoria A Brentville. Biomedicines, 2018 Mar 24; 6(2). PMID: 29570634 Free PMC article. Review.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada. less Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375 Free PMC article. Highly Cited.
Anti-CTLA-4 therapy requires an Fc domain for efficacy. Jessica R Ingram, Olga S Blomberg, +15 authors, Michael Dougan. less Proc Natl Acad Sci U S A, 2018 Mar 28; 115(15). PMID: 29581255 Free PMC article. Highly Cited.
Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes. Kalpana Mujoo, Clayton R Hunt, +5 authors, Tej K Pandita. less Mol Cancer Res, 2018 Mar 30; 16(8). PMID: 29592896 Free PMC article. Review.
Anti-CTLA-4 immunotherapy: uncoupling toxicity and efficacy. Jonathan Pol, Guido Kroemer. Cell Res, 2018 Mar 30; 28(5). PMID: 29593340 Free PMC article.
Immunotherapy combination strategies (non-chemotherapy) in non-small cell lung cancer. Sandrine Niyongere, Andreas Saltos, Jhanelle E Gray. J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593889 Free PMC article. Review.
Targeting Macrophages in Cancer: From Bench to Bedside. Ashleigh R Poh, Matthias Ernst. Front Oncol, 2018 Mar 30; 8. PMID: 29594035 Free PMC article. Highly Cited. Review.
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. Randi B Gombos, Ana Gonzalez, +24 authors, Nicholas S Wilson. less PLoS One, 2018 Apr 05; 13(4). PMID: 29617360 Free PMC article.
IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy. Jianmin Zhu, Jin-Qing Liu, +11 authors, Xue-Feng Bai. less JCI Insight, 2018 Apr 06; 3(7). PMID: 29618655 Free PMC article.
Combination Immunotherapy: Taking Cancer Vaccines to the Next Level. Jeremy M Grenier, Stephen T Yeung, Kamal M Khanna. Front Immunol, 2018 Apr 07; 9. PMID: 29623082 Free PMC article. Review.
Macrophages: The Road Less Traveled, Changing Anticancer Therapy. Jennifer L Guerriero. Trends Mol Med, 2018 Apr 16; 24(5). PMID: 29655673 Free PMC article. Highly Cited. Review.
An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides. Laura L Eggink, Katherine F Roby, Robert Cote, J Kenneth Hoober. J Immunother Cancer, 2018 Apr 19; 6(1). PMID: 29665849 Free PMC article.
Targeting Tumor-Associated Macrophages as a Potential Strategy to Enhance the Response to Immune Checkpoint Inhibitors. Luca Cassetta, Takanori Kitamura. Front Cell Dev Biol, 2018 Apr 20; 6. PMID: 29670880 Free PMC article. Highly Cited. Review.
Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade? Fei Tang, Xuexiang Du, +2 authors, Mingyue Liu, Pan Zheng, Yang Liu. less Cell Biosci, 2018 May 02; 8. PMID: 29713453 Free PMC article.
Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors. Erika J Crosby, Junping Wei, +10 authors, Zachary C Hartman. less Oncoimmunology, 2018 May 04; 7(5). PMID: 29721371 Free PMC article.
Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity. Marka R Crittenden, Lauren Zebertavage, +7 authors, Michael J Gough. less Sci Rep, 2018 May 05; 8(1). PMID: 29725089 Free PMC article.
Transcriptional characterization of immunological infiltrates and their relation with glioblastoma patients overall survival. Mariana Brutschin Pereira, Luciana Rodrigues Carvalho Barros, +4 authors, Guido Lenz. less Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872555 Free PMC article.
RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer. Elizabeth Ahern, Heidi Harjunpää, +4 authors, Mark J Smyth. less Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872559 Free PMC article.
Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors. Ee Lyn Lim, Fiorella M Cugliandolo, +3 authors, Klaus Okkenhaug. less JCI Insight, 2018 Jun 08; 3(11). PMID: 29875319 Free PMC article.
Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens. Jeremy D Waight, Dhan Chand, +14 authors, Nicholas S Wilson. less Cancer Cell, 2018 Jun 13; 33(6). PMID: 29894690 Free PMC article.
Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. David Wang, Jason Quiros, +12 authors, Michel DuPage. less Cell Rep, 2018 Jun 14; 23(11). PMID: 29898397 Free PMC article. Highly Cited.
The promise and challenges of immune agonist antibody development in cancer. Patrick A Mayes, Kenneth W Hance, Axel Hoos. Nat Rev Drug Discov, 2018 Jun 16; 17(7). PMID: 29904196 Highly Cited. Review.
Aptamers: novelty tools for cancer biology. Ricardo L Pereira, Isis C Nascimento, +4 authors, Henning Ulrich. less Oncotarget, 2018 Jun 22; 9(42). PMID: 29928493 Free PMC article. Review.
Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets. Matthew H Bakalar, Aaron M Joffe, +3 authors, Daniel A Fletcher. less Cell, 2018 Jun 30; 174(1). PMID: 29958103 Free PMC article. Highly Cited.
Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers. Muhammad Umair Mushtaq, Athanasios Papadas, +4 authors, Fotis Asimakopoulos. less J Immunother Cancer, 2018 Jul 05; 6(1). PMID: 29970158 Free PMC article. Review.
Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy. Lekh N Dahal, Chie-Yin Huang, +10 authors, Stephen A Beers. less J Immunol, 2018 Jul 13; 201(4). PMID: 29997125 Free PMC article.
Novel tumour antigens and the development of optimal vaccine design. Victoria A Brentville, Suha Atabani, Katherine Cook, Lindy G Durrant. Ther Adv Vaccines Immunother, 2018 Jul 13; 6(2). PMID: 29998219 Free PMC article. Review.
Efficacy and immune activation of ipilimumab in early-stage lung cancer patients. Shingo Noguchi, Kazuhiro Yatera. J Thorac Dis, 2018 Jul 20; 10(Suppl 17). PMID: 30023087 Free PMC article.
Glyco-Engineered Anti-Human Programmed Death-Ligand 1 Antibody Mediates Stronger CD8 T Cell Activation Than Its Normal Glycosylated and Non-Glycosylated Counterparts. Christoph Goletz, Timo Lischke, +4 authors, Steffen Goletz. less Front Immunol, 2018 Aug 01; 9. PMID: 30061887 Free PMC article.
Treg Fragility: A Prerequisite for Effective Antitumor Immunity? Abigail E Overacre-Delgoffe, Dario A A Vignali. Cancer Immunol Res, 2018 Aug 03; 6(8). PMID: 30068755 Free PMC article. Review.
Current landscape and future directions of biomarkers for predicting responses to immune checkpoint inhibitors. Yingming Zhu, Fen Zhao, Zhenxiang Li, Jinming Yu. Cancer Manag Res, 2018 Aug 21; 10. PMID: 30122997 Free PMC article. Review.
Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity. Brett Schrand, Emily Clark, +5 authors, Eli Gilboa. less Nat Commun, 2018 Aug 24; 9(1). PMID: 30135425 Free PMC article.
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance. Young-Jun Park, Da-Sol Kuen, Yeonseok Chung. Exp Mol Med, 2018 Aug 24; 50(8). PMID: 30135516 Free PMC article. Highly Cited. Review.
Strategies for Predicting Response to Checkpoint Inhibitors. Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub. Curr Hematol Malig Rep, 2018 Aug 31; 13(5). PMID: 30159703 Free PMC article. Review.
Prognostic significance of tumor immune microenvironment and immunotherapy: Novel insights and future perspectives in gastric cancer. Daniela Cornelia Lazăr, Mihaela Flavia Avram, +3 authors, Adrian Goldiș. less World J Gastroenterol, 2018 Sep 01; 24(32). PMID: 30166856 Free PMC article. Highly Cited. Review.
Neurologic immune-related adverse events associated with adjuvant ipilimumab: report of two cases. Christine A Garcia, Alex El-Ali, +4 authors, Diwakar Davar. less J Immunother Cancer, 2018 Sep 02; 6(1). PMID: 30170622 Free PMC article.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity. Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar. J Autoimmun, 2018 Sep 04; 95. PMID: 30174217 Free PMC article. Review.
Autochthonous murine models for the study of smoker and never-smoker associated lung cancers. Esra A Akbay, James Kim. Transl Lung Cancer Res, 2018 Sep 19; 7(4). PMID: 30225211 Free PMC article. Review.
Not All Immune Checkpoints Are Created Equal. Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger. Front Immunol, 2018 Sep 21; 9. PMID: 30233564 Free PMC article. Highly Cited. Review.
Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells. Nayoung Kim, Hun Sik Kim. Front Immunol, 2018 Sep 27; 9. PMID: 30250471 Free PMC article. Highly Cited. Review.
Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity. David A Knorr, Rony Dahan, Jeffrey V Ravetch. Proc Natl Acad Sci U S A, 2018 Oct 10; 115(43). PMID: 30297432 Free PMC article.
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CTLA-4 Immunohistochemistry and Quantitative Image Analysis for Profiling of Human Cancers. Charles Brown, Farzad Sekhavati, +4 authors, Keith E Steele. less J Histochem Cytochem, 2019 Oct 15; 67(12). PMID: 31609157 Free PMC article.
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Mucosal HPV E6/E7 Peptide Vaccination in Combination with Immune Checkpoint Modulation Induces Regression of HPV+ Oral Cancers. Stephanie Dorta-Estremera, Renee L Chin, +7 authors, K Jagannadha Sastry. less Cancer Res, 2018 Jul 29; 78(18). PMID: 30054333 Free PMC article.
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FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy. Xin Chen, Xiaomin Song, Kang Li, Tong Zhang. Front Immunol, 2019 Mar 14; 10. PMID: 30863404 Free PMC article. Highly Cited. Review.
Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges. Ilenia Pacella, Silvia Piconese. Front Immunol, 2019 Sep 12; 10. PMID: 31507585 Free PMC article. Review.
Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study. Antonio Marchini, Laurent Daeffler, +2 authors, Vitaly I Pozdeev, Assia Angelova, Jean Rommelaere. less Front Immunol, 2019 Aug 24; 10. PMID: 31440242 Free PMC article. Review.
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IL36 Cooperates With Anti-CTLA-4 mAbs to Facilitate Antitumor Immune Responses. Qiuxia Qu, Zhiwei Zhai, +3 authors, Jieni Xu, Song Li, Cheng Chen, Binfeng Lu. less Front Immunol, 2020 May 01; 11. PMID: 32351508 Free PMC article.
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Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy. Yang Liu, Pan Zheng. Trends Pharmacol Sci, 2019 Dec 15; 41(1). PMID: 31836191 Free PMC article. Review.
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Beyond immune checkpoint blockade: emerging immunological strategies. Shawn P Kubli, Thorsten Berger, +2 authors, Daniel V Araujo, Lillian L Siu, Tak W Mak. less Nat Rev Drug Discov, 2021 Mar 10; 20(12). PMID: 33686237 Review.
The Impact of Tregs on the Anticancer Immunity and the Efficacy of Immune Checkpoint Inhibitor Therapies. Jose M González-Navajas, Dengxia Denise Fan, +4 authors, Jongdae Lee. less Front Immunol, 2021 Mar 16; 12. PMID: 33717139 Free PMC article. Review.
Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma. Franziska K Krebs, Emily R Trzeciak, +6 authors, Andrea Tuettenberg. less Cancer Med, 2021 Jan 16; 10(5). PMID: 33449393 Free PMC article.
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Roles of the Dynamic Tumor Immune Microenvironment in the Individualized Treatment of Advanced Clear Cell Renal Cell Carcinoma. Enyu Lin, Xuechao Liu, +5 authors, Yuming Yu. less Front Immunol, 2021 Mar 23; 12. PMID: 33746989 Free PMC article. Review.
The Mechanisms Leading to Distinct Responses to PD-1/PD-L1 Blockades in Colorectal Cancers With Different MSI Statuses. Guanglin Cui. Front Oncol, 2021 Mar 26; 11. PMID: 33763344 Free PMC article. Review.
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Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report. Periklis Kyriazis, Abhinav Tiwary, +2 authors, Jonathan Freeman, Daniel Landry, Gregory Braden. less J Med Case Rep, 2021 Apr 04; 15(1). PMID: 33810799 Free PMC article.
OX40 as a novel target for the reversal of immune escape in colorectal cancer. Lin-Hai Yan, Xiao-Liang Liu, +3 authors, Si-Si Mo, Di Zhang, Xian-Wei Mo, Wei-Zhong Tang. less Am J Transl Res, 2021 Apr 13; 13(3). PMID: 33841630 Free PMC article. Review.
Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy. Benedetta Apollonio, Nikolaos Ioannou, Despoina Papazoglou, Alan G Ramsay. Front Oncol, 2021 Apr 13; 11. PMID: 33842331 Free PMC article. Review.
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Explant Modeling of the Immune Environment of Head and Neck Cancer. Shay Sharon, Thomas Duhen, +9 authors, Michael Gough. less Front Oncol, 2021 Jul 06; 11. PMID: 34221953 Free PMC article.
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It. Elena Shklovskaya, Helen Rizos. Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34201655 Free PMC article. Review.
Pouring petrol on the flames: Using oncolytic virotherapies to enhance tumour immunogenicity. Alicia Teijeira Crespo, Stephanie Burnell, +7 authors, Alan L Parker. less Immunology, 2021 Feb 28; 163(4). PMID: 33638871 Free PMC article. Review.
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy. Bonnie L Russell, Selisha A Sooklal, +2 authors, Monde Ntwasa. less Front Oncol, 2021 Jul 17; 11. PMID: 34268109 Free PMC article. Review.
Type 1 conventional dendritic cells and interferons are required for spontaneous CD4+ and CD8+ T-cell protective responses to breast cancer. Raphaël Mattiuz, Carine Brousse, +9 authors, Karine Crozat. less Clin Transl Immunology, 2021 Jul 20; 10(7). PMID: 34277006 Free PMC article.
Emerging Technologies for Non-invasive Monitoring of Treatment Response to Immunotherapy for Brain Tumors. Dimitrios Mathios, Siddhartha Srivastava, +2 authors, Timothy Kim, Chetan Bettegowda, Michael Lim. less Neuromolecular Med, 2021 Jul 24;. PMID: 34297308 Review.
The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy. Reza Bayat Mokhtari, Manpreet Sambi, +7 authors, Myron R Szewczuk. less Cancers (Basel), 2021 Jul 25; 13(14). PMID: 34298809 Free PMC article. Review.
Alternol triggers immunogenic cell death via reactive oxygen species generation. Changlin Li, Ying Zhang, +4 authors, Benyi Li. less Oncoimmunology, 2021 Aug 06; 10(1). PMID: 34350063 Free PMC article.
Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer. Jessica Castrillon Lal, Madeline G Townsend, +7 authors, Jennifer L Guerriero. less Breast Cancer Res, 2021 Aug 07; 23(1). PMID: 34353349 Free PMC article.
Recent Advances in Glioma Therapy: Combining Vascular Normalization and Immune Checkpoint Blockade. Rachel L Y Ho, Ivy A W Ho. Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359588 Free PMC article. Review.
Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors. Emily F Davis-Marcisak, Allison A Fitzgerald, +5 authors, Elana J Fertig. less Genome Med, 2021 Aug 12; 13(1). PMID: 34376232 Free PMC article.
Virus-Like Particle-Drug Conjugates Induce Protective, Long-lasting Adaptive Antitumor Immunity in the Absence of Specifically Targeted Tumor Antigens. Rhonda C Kines, Cynthia D Thompson, +4 authors, John T Schiller. less Cancer Immunol Res, 2021 Apr 16; 9(6). PMID: 33853825 Free PMC article.
The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives. Aymara Sancho-Araiz, Victor Mangas-Sanjuan, Iñaki F Trocóniz. Pharmaceutics, 2021 Aug 11; 13(7). PMID: 34371708 Free PMC article. Review.
Immune suppressive checkpoint interactions in the tumour microenvironment of primary liver cancers. Guoying Zhou, Patrick P C Boor, +2 authors, Marco J Bruno, Dave Sprengers, Jaap Kwekkeboom. less Br J Cancer, 2021 Aug 18; 126(1). PMID: 34400801 Free PMC article. Review.
LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells. Takahiro Yamazaki, Erik Wennerberg, +8 authors, Lorenzo Galluzzi. less Oncoimmunology, 2021 Aug 20; 10(1). PMID: 34408925 Free PMC article.
Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy. David M Francis, Margaret P Manspeaker, +6 authors, Susan N Thomas. less Sci Transl Med, 2020 Oct 02; 12(563). PMID: 32998971 Free PMC article.
Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids. Firas Hamdan, Erkko Ylösmäki, +18 authors, Vincenzo Cerullo. less J Immunother Cancer, 2021 Aug 08; 9(8). PMID: 34362830 Free PMC article.
Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies. Hiroyoshi Nishikawa, Shohei Koyama. J Immunother Cancer, 2021 Aug 01; 9(7). PMID: 34330764 Free PMC article. Review.
Identification of Autophagy- and Ferroptosis-Related lncRNAs Functioned through Immune-Related Pathways in Head and Neck Squamous Carcinoma. Qi Guo, Xuehan Zhang, Tao Shen, Xiangting Wang. Life (Basel), 2021 Aug 28; 11(8). PMID: 34440579 Free PMC article.
Strategies to Improve the Antitumor Effect of γδ T Cell Immunotherapy for Clinical Application. Masatsugu Miyashita, Teruki Shimizu, Eishi Ashihara, Osamu Ukimura. Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445615 Free PMC article. Review.
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation. Kotaro Sugawara, Miwako Iwai, +3 authors, Tomoki Todo. less Mol Ther Oncolytics, 2021 Sep 14; 22. PMID: 34514094 Free PMC article.
Soluble B7-CD28 Family Inhibitory Immune Checkpoint Proteins and Anti-Cancer Immunotherapy. Muhammad Khan, Sumbal Arooj, Hua Wang. Front Immunol, 2021 Sep 18; 12. PMID: 34531847 Free PMC article. Review.
Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle. Aikaterini Hatzioannou, Athina Boumpas, +4 authors, Panayotis Verginis. less Front Immunol, 2021 Sep 21; 12. PMID: 34539668 Free PMC article. Review.
GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment. Alexanne Bouchard, Bertrand Collin, +2 authors, Carmen Garrido, Pierre-Simon Bellaye, Evelyne Kohli. less Biology (Basel), 2021 Sep 29; 10(9). PMID: 34571713 Free PMC article. Review.
Bringing Macrophages to the Frontline against Cancer: Current Immunotherapies Targeting Macrophages. Mariana Reis-Sobreiro, Afonso Teixeira da Mota, Carolina Jardim, Karine Serre. Cells, 2021 Sep 29; 10(9). PMID: 34572013 Free PMC article. Review.
NSCLC Biomarkers to Predict Response to Immunotherapy with Checkpoint Inhibitors (ICI): From the Cells to In Vivo Images. Virginia Liberini, Annapaola Mariniello, +7 authors, Désirée Deandreis. less Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572771 Free PMC article. Review.
Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A Rational Indicator of Antitumor Response and Immune Checkpoint Blockade. Yasuhiro Kanda, Taku Okazaki, Tomoya Katakai. Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572844 Free PMC article. Review.
Targeting the spectrum of immune checkpoints in prostate cancer. Laura A Sena, Samuel R Denmeade, Emmanuel S Antonarakis. Expert Rev Clin Pharmacol, 2021 Jul 16; 14(10). PMID: 34263692 Free PMC article. Review.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang. less Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187 Free PMC article.
Remodeling the Tumor Myeloid Landscape to Enhance Antitumor Antibody Immunotherapies. Khiyam Hussain, Mark S Cragg, Stephen A Beers. Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638388 Free PMC article. Review.
CD200 Blockade Modulates Tumor Immune Microenvironment but Fails to Show Efficacy in Inhibiting Tumor Growth in a Murine Model of Melanoma. Fatemeh Talebian, Jianyu Yu, +3 authors, Xue-Feng Bai. less Front Cell Dev Biol, 2021 Oct 26; 9. PMID: 34692697 Free PMC article.
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness. Daniel Hirschhorn, Allison Betof Warner, +11 authors, Jedd D Wolchok. less JCI Insight, 2021 Oct 23; 6(20). PMID: 34676831 Free PMC article.
Engineering a variant of IL-17RA with high binding affinity to IL-17A for optimized immunotherapy. Fatemeh Armaghan, Zahra Hajihassan. Biotechnol Rep (Amst), 2021 Nov 13; 32. PMID: 34765462 Free PMC article.
Tumor-immune profiling of CT-26 and Colon 26 syngeneic mouse models reveals mechanism of anti-PD-1 response. Yosuke Sato, Yu Fu, +2 authors, Hong Liu, Min Young Lee, Michael H Shaw. less BMC Cancer, 2021 Nov 15; 21(1). PMID: 34774008 Free PMC article.
Biological Bases of Immune-Related Adverse Events and Potential Crosslinks With Immunogenic Effects of Radiation. Lilia Bardoscia, Nadia Pasinetti, +2 authors, Luca Triggiani, Salvatore Cozzi, Angela Sardaro. less Front Pharmacol, 2021 Nov 19; 12. PMID: 34790123 Free PMC article. Review.
Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity. Deyong Song, Xiu Liu, +12 authors, Changlin Dou. less Sci Rep, 2021 Nov 27; 11(1). PMID: 34824364 Free PMC article.
[Clinical Trial Progress and Application of Immune Checkpoint Inhibitors  in the Treatment of Small Cell Lung Cancer]. Huiqiu Zhang, Xiyang Li, Xichuan Li, Yanjun Su. Zhongguo Fei Ai Za Zhi, 2021 Nov 22; 24(11). PMID: 34802211 Free PMC article.
Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer. Jianyu Liu, Xueying Wang, +3 authors, Yuhan Deng, Xin Yu, Hongbin Wang, Zhigao Li. less Front Oncol, 2021 Dec 07; 11. PMID: 34868991 Free PMC article. Review.
Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy. R R Maniyar, S Chakraborty, +4 authors, R K Tiwari. less Adv Exp Med Biol, 2021 Dec 11; 1350. PMID: 34888847
Steatosis, Steatohepatitis and Cancer Immunotherapy: An Intricate Story. Mauro Cataldi, Federica Manco, Giovanni Tarantino. Int J Mol Sci, 2021 Dec 11; 22(23). PMID: 34884762 Free PMC article. Review.
Strategies to Improve the Antitumor Effect of Immunotherapy for Hepatocellular Carcinoma. Rui Xing, Jinping Gao, Qi Cui, Qian Wang. Front Immunol, 2021 Dec 14; 12. PMID: 34899747 Free PMC article. Review.
Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors. Takuro Saito, Koji Kurose, +11 authors, Hisashi Wada. less Nagoya J Med Sci, 2021 Dec 18; 83(4). PMID: 34916725 Free PMC article.
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Francesco Marangoni, Ademi Zhakyp, +10 authors, Thorsten R Mempel. less Cell, 2021 Jun 23; 184(15). PMID: 34157302 Free PMC article.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial. Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg. Nat Rev Drug Discov, 2021 Dec 24;. PMID: 34937915 Review.
Predictive Biomarkers for Outcomes of Immune Checkpoint Inhibitors (ICIs) in Melanoma: A Systematic Review. Joosje C Baltussen, Marij J P Welters, +7 authors, Nienke A de Glas. less Cancers (Basel), 2021 Dec 25; 13(24). PMID: 34944986 Free PMC article. Review.
Our current understanding of checkpoint inhibitor therapy in cancer immunotherapy. Elena Goleva, Taras Lyubchenko, +3 authors, Jeffrey A Kern. less Ann Allergy Asthma Immunol, 2021 Mar 16; 126(6). PMID: 33716146 Free PMC article. Review.
Resistance to Immunotherapy: Mechanisms and Means for Overcoming. Mohamad A Salkeni, John Y Shin, James L Gulley. Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972962
Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier. Somayeh Vafaei, Angelina O Zekiy, +4 authors, Majid Zamani. less Cancer Cell Int, 2022 Jan 05; 22(1). PMID: 34980128 Free PMC article. Review.
Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors. Nicola J Mason, Nicholas Chester, +6 authors, Don L Siegel. less MAbs, 2021 Dec 04; 13(1). PMID: 34856888 Free PMC article.
Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD. Zixuan Wang, Zixin Tian, Xi Song, Jun Zhang. BMC Immunol, 2022 Jan 10; 23(1). PMID: 34998385 Free PMC article.
Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy. Myriam Ben Khelil, Yann Godet, +3 authors, Romain Loyon. less Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008422 Free PMC article. Review.
Mechanisms of immune checkpoint inhibitor-mediated liver injury. Layla Shojaie, Myra Ali, Andrea Iorga, Lily Dara. Acta Pharm Sin B, 2022 Jan 14; 11(12). PMID: 35024302 Free PMC article. Review.
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Golnaz Morad, Beth A Helmink, Padmanee Sharma, Jennifer A Wargo. Cell, 2021 Oct 09; 184(21). PMID: 34624224 Free PMC article. Review.
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions. Ming Yi, Xiaoli Zheng, +3 authors, Mengke Niu, Shuangli Zhu, Hong Ge, Kongming Wu. less Mol Cancer, 2022 Jan 23; 21(1). PMID: 35062949 Free PMC article. Review.
TGFβ2 Induces the Soluble Isoform of CTLA-4 - Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma. Rahul C Khanolkar, Chu Zhang, +11 authors, Frank James Ward. less Front Immunol, 2022 Jan 25; 12. PMID: 35069536 Free PMC article.
PD-L1 expression and immune cells infiltration in primary tracheobronchial neoplasm. Kai-Fu Zheng, Yu-Jian Liu, +12 authors, Jin-Bo Zhao. less Transl Lung Cancer Res, 2022 Jan 25; 10(12). PMID: 35070765 Free PMC article.
Understanding neutropenia secondary to intrinsic or iatrogenic immune dysregulation. Kelly Walkovich, James A Connelly. Hematology Am Soc Hematol Educ Program, 2021 Dec 11; 2021(1). PMID: 34889406 Free PMC article.
Macrophages as a Therapeutic Target in Metastatic Prostate Cancer: A Way to Overcome Immunotherapy Resistance? Clara Martori, Lidia Sanchez-Moral, +4 authors, Maria-Rosa Sarrias. less Cancers (Basel), 2022 Jan 22; 14(2). PMID: 35053602 Free PMC article. Review.
Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject 'cold' tumors. Monika Semmrich, Jean-Baptiste Marchand, +15 authors, Björn Frendéus. less J Immunother Cancer, 2022 Jan 22; 10(1). PMID: 35058324 Free PMC article.
Defining unique clinical hallmarks for immune checkpoint inhibitor-based therapies. Olivier Michielin, Aly-Khan Lalani, +2 authors, Caroline Robert, Padmanee Sharma, Solange Peters. less J Immunother Cancer, 2022 Jan 27; 10(1). PMID: 35078922 Free PMC article. Review.
Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1. Yuwei Hao, Matthew C Cook. Front Immunol, 2022 Feb 15; 12. PMID: 35154081 Free PMC article. Review.
Age effects of distinct immune checkpoint blockade treatments in a mouse melanoma model. Álvaro Padrón, Vincent Hurez, +8 authors, Tyler J Curiel. less Exp Gerontol, 2018 Jan 13; 105. PMID: 29326088 Free PMC article.
Identification and Characterization of Immunogene-Related Alternative Splicing Patterns and Tumor Microenvironment Infiltration Patterns in Breast Cancer. Shuang Guo, Xinyue Wang, +12 authors, Shangwei Ning. less Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158863 Free PMC article.
Immune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities. Youra Kim, Prathyusha Konda, +3 authors, Shashi Gujar. less Mol Cell Proteomics, 2021 Dec 19; 21(2). PMID: 34922008 Free PMC article.
Fc-independent functions of anti-CTLA-4 antibodies contribute to anti-tumor efficacy. Yosuke Sato, Cierra N Casson, +14 authors, Michael H Shaw. less Cancer Immunol Immunother, 2022 Mar 04;. PMID: 35237846
Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma. Meng-Ju Wu, Lei Shi, +30 authors, Nabeel Bardeesy. less Cancer Discov, 2021 Dec 02; 12(3). PMID: 34848557 Free PMC article.
An Fc-Competent Anti-Human TIGIT Blocking Antibody Ociperlimab (BGB-A1217) Elicits Strong Immune Responses and Potent Anti-Tumor Efficacy in Pre-Clinical Models. Xin Chen, Liu Xue, +23 authors, Tong Zhang. less Front Immunol, 2022 Mar 12; 13. PMID: 35273608 Free PMC article.
Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering. Franziska Heckel, Anna H Turaj, +12 authors, Sean H Lim. less Commun Biol, 2022 Mar 16; 5(1). PMID: 35288635 Free PMC article.
Lenvatinib Plus Camrelizumab vs. Lenvatinib Monotherapy as First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Multicenter Retrospective Cohort Study. Qi Li, Mengran Cao, +9 authors, Jinzhang Chen. less Front Oncol, 2022 Mar 15; 12. PMID: 35280760 Free PMC article.
Addressing the Elephant in the Immunotherapy Room: Effector T-Cell Priming versus Depletion of Regulatory T-Cells by Anti-CTLA-4 Therapy. Megan M Y Hong, Saman Maleki Vareki. Cancers (Basel), 2022 Mar 26; 14(6). PMID: 35326731 Free PMC article. Review.
Combinations of radiotherapy with immunotherapy in cervical cancer. Xiaojing Yang, Hanru Ren, Jie Fu. J Cancer, 2022 Apr 05; 13(5). PMID: 35371317 Free PMC article. Review.
HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy. Khiyam Hussain, Rena Liu, +28 authors, Mark S Cragg. less J Exp Clin Cancer Res, 2022 Apr 09; 41(1). PMID: 35392965 Free PMC article.
Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons. Adel Naimi, Rebar N Mohammed, +11 authors, Ehsan Razeghian. less Cell Commun Signal, 2022 Apr 09; 20(1). PMID: 35392976 Free PMC article. Review.
Immunomodulatory Properties of Immune Checkpoint Inhibitors-More than Boosting T-Cell Responses? Michael Kuske, Maximilian Haist, +2 authors, Thomas Jung, Stephan Grabbe, Matthias Bros. less Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406483 Free PMC article. Review.
Enhanced T-Cell Priming and Improved Anti-Tumor Immunity through Lymphatic Delivery of Checkpoint Blockade Immunotherapy. Carolina Mantilla-Rojas, Fred C Velasquez, +4 authors, Eva M Sevick-Muraca. less Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406595 Free PMC article.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis. Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom. Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201 Review.
The Role of Myeloid Cells in Hepatotoxicity Related to Cancer Immunotherapy. Cathrin L C Gudd, Lucia A Possamai. Cancers (Basel), 2022 Apr 24; 14(8). PMID: 35454819 Free PMC article. Review.
Exploring the Mechanisms Underlying the Cardiotoxic Effects of Immune Checkpoint Inhibitor Therapies. Daniel Ronen, Aseel Bsoul, +4 authors, Rabea Asleh. less Vaccines (Basel), 2022 Apr 24; 10(4). PMID: 35455289 Free PMC article. Review.
The immune checkpoint B7x expands tumor-infiltrating Tregs and promotes resistance to anti-CTLA-4 therapy. Peter John, Marc C Pulanco, +4 authors, Xingxing Zang. less Nat Commun, 2022 May 07; 13(1). PMID: 35523809

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