Journal Article
. 2013 Sep;3(3).
doi: 10.1007/s13193-012-0149-z.

Statistics for surgeons - understanding survival analysis

Girdhar Gopal Agarwal 1 
Affiliations
  • PMID: 23997508
  •     8 References
  •     2 citations

Abstract

Survival data stand out as a special statistical field. This paper tries to describe what survival data is and what makes it so special. Survival data concerns times to some events. A key point is the successive observation of time, which on the one hand leads to sometimes not being observed so that all that is known is that they exceed some given times (censoring), and on the other hand implies that predictions regarding the future course should be conditional on the present status (truncation). In the simplest case, this condition is that the individual is alive. The successive conditioning makes the hazard function, which describes the probability of an event happening during a short interval given that the individual is alive today, the most relevant concept. Here we discuss parametric as well as non-parametric methods. Examples are presented in a way that can be followed without the help of computers.

Keywords: Censored data; Hazard function; Kaplan-Meier estimate; Logrank test; Survivor function.

Adjuvant chemoimmunotherapy after regional lymphadenectomy for malignant melanoma.
E A Abdi, J Hanson, T A McPherson.
Am J Clin Oncol, 1987 Apr 01; 10(2). PMID: 3565312
The relative survival rate: a statistical methodology.
F EDERER, L M AXTELL, S J CUTLER.
Natl Cancer Inst Monogr, 1961 Sep 01; 6. PMID: 13889176
Highly Cited.
Censoring in an epidemic with an application to hemophilia-associated AIDS.
R Brookmeyer, J J Goedert.
Biometrics, 1989 Mar 01; 45(1). PMID: 2720058
Statistical methods for the identification and use of prognostic factors.
P Armitage, E A Gehan.
Int J Cancer, 1974 Jan 15; 13(1). PMID: 4594339
Review.
Combination chemotherapy as an adjuvant treatment in operable breast cancer.
G Bonadonna, E Brusamolino, +8 authors, U Veronesi.
N Engl J Med, 1976 Feb 19; 294(8). PMID: 1246307
Highly Cited.
Designs for group sequential tests.
T R Fleming, D P Harrington, P C O'Brien.
Control Clin Trials, 1984 Dec 01; 5(4). PMID: 6518769
Cancer-specific beliefs and survival: a population-based study of African-American and White breast cancer patients.
Hosanna Soler-Vila, Stanislav V Kasl, Beth A Jones.
Cancer Causes Control, 2005 May 04; 16(2). PMID: 15868452
Long term survival analysis: the curability of breast cancer.
S J Pocock, S M Gore, G R Kerr.
Stat Med, 1982 Apr 01; 1(2). PMID: 7187092
Converging or Crossing Curves: Untie the Gordian Knot or Cut it? Appropriate Statistics for Non-Proportional Hazards in Decitabine DACO-016 Study (AML).
Jörg Tomeczkowski, Ansgar Lange, +5 authors, Christoph Tapprich.
Adv Ther, 2015 Sep 16; 32(9). PMID: 26369324    Free PMC article.
Clinicopathological characteristics, adjuvant chemotherapy decision and disease outcome in patients with breast cancer with a 21-gene recurrence score of 26-30.
Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724396    Free PMC article.