Review
. 2013 Sep; 72(4):399-406.
doi: 10.1017/S0029665113003029.

Fruit and vegetable intake and risk of cardiovascular disease

Jayne V Woodside 1 Ian S Young  Michelle C McKinley  
Affiliations
  • PMID: 24050503
  •     27 citations

Abstract

A high intake of fruit and vegetables (FV) has been shown to be associated with reduced risk of a number of chronic diseases, including CVD. This review aims to provide an overview of the evidence that increased FV intake reduces risk of CVD, focusing on studies examining total FV intake. This evidence so far available is largely based on prospective cohort studies, with meta-analyses demonstrating an association between increased FV intake and reduced risk of both CHD and stroke. Controlled intervention trials examining either clinical or cardiovascular risk factor endpoints are scarce. However, such trials have shown that an increase in FV consumption can lower blood pressure and also improve microvascular function, both of which are commensurate with a reduced risk of CVD. The effects of increased FV consumption on plasma lipid levels, risk of diabetes and body weight have yet to be firmly established. In conclusion, evidence that FV consumption reduces the risk of CVD is so far largely confined to observational epidemiology, with further intervention studies required.

NutriChem: a systems chemical biology resource to explore the medicinal value of plant-based foods.
Kasper Jensen, Gianni Panagiotou, Irene Kouskoumvekaki.
Nucleic Acids Res, 2014 Aug 12; 43(Database issue). PMID: 25106869    Free PMC article.
Urinary thiocyanate concentrations are associated with adult cancer and lung problems: US NHANES, 2009-2012.
Ivy Shiue.
Environ Sci Pollut Res Int, 2014 Nov 05; 22(8). PMID: 25367645
Jamie's Ministry of Food: quasi-experimental evaluation of immediate and sustained impacts of a cooking skills program in Australia.
Anna Flego, Jessica Herbert, +4 authors, Marj Moodie.
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Apples and cardiovascular health--is the gut microbiota a core consideration?
Athanasios Koutsos, Kieran M Tuohy, Julie A Lovegrove.
Nutrients, 2015 May 29; 7(6). PMID: 26016654    Free PMC article.
Review.
Vitamin C: the known and the unknown and Goldilocks.
S J Padayatty, M Levine.
Oral Dis, 2016 Jan 26; 22(6). PMID: 26808119    Free PMC article.
Highly Cited. Review.
Persimmon (Diospyros kaki) fruit: hidden phytochemicals and health claims.
Masood Sadiq Butt, M Tauseef Sultan, +4 authors, Muhammad Imran.
EXCLI J, 2015 Jan 01; 14. PMID: 27047315    Free PMC article.
Review.
Consumption of fruits and vegetables associated with other risk behaviors among adolescents in Northeast Brazil.
Fabiana Medeiros de Almeida Silva, Aldemir Smith-Menezes, Maria de Fátima da Silva Duarte.
Rev Paul Pediatr, 2016 Jun 01; 34(3). PMID: 27240560    Free PMC article.
Farm-to-Consumer Retail Outlet Use, Fruit and Vegetable Intake, and Obesity Status among WIC Program Participants in Alabama.
Chelsea R Singleton, Monica Baskin, +3 authors, Olivia Affuso.
Am J Health Behav, 2016 Jun 25; 40(4). PMID: 27338991    Free PMC article.
The Association between Changes in Behavioral Risk Factors for Stroke and Changes in Blood Pressure.
Lewis B Morgenstern, Brisa N Sánchez, +5 authors, Devin L Brown.
J Stroke Cerebrovasc Dis, 2016 Jun 28; 25(9). PMID: 27342699    Free PMC article.
Parental involvement and association with adolescents' fruit and vegetable intake at follow-up: Process evaluation results from the multi-component school-based Boost intervention.
Sanne Ellegård Jørgensen, Thea Suldrup Jørgensen, +2 authors, Rikke Krølner.
Int J Behav Nutr Phys Act, 2016 Oct 27; 13(1). PMID: 27782838    Free PMC article.
Plant-based foods containing cell wall polysaccharides rich in specific active monosaccharides protect against myocardial injury in rat myocardial infarction models.
Sun Ha Lim, Yaesil Kim, +4 authors, Jongwon Lee.
Sci Rep, 2016 Dec 09; 6. PMID: 27929093    Free PMC article.
Impact of Flavonols on Cardiometabolic Biomarkers:  A Meta-Analysis of Randomized Controlled Human  Trials to Explore the Role of Inter-Individual  Variability.
Regina Menezes, Ana Rodriguez-Mateos, +14 authors, Paula Pinto.
Nutrients, 2017 Feb 18; 9(2). PMID: 28208791    Free PMC article.
Systematic Review.
Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial.
Susan J Duthie, Garry G Duthie, +14 authors, Charles S Bestwick.
Eur J Nutr, 2017 Jun 01; 57(5). PMID: 28560503    Free PMC article.
Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota.
Ming Lyu, Yue-Fei Wang, +3 authors, Yan Zhu.
Front Microbiol, 2017 Nov 24; 8. PMID: 29167659    Free PMC article.
Review.
A multi-level intervention in worksites to increase fruit and vegetable access and intake: Rationale, design and methods of the 'Good to Go' cluster randomized trial.
Patricia M Risica, Gemma Gorham, +7 authors, Kim M Gans.
Contemp Clin Trials, 2017 Dec 16; 65. PMID: 29242108    Free PMC article.
Frequency of Fruit and Vegetable Consumption and the Oral Health-Related Quality of Life among Japanese Elderly: A Cross-Sectional Study from the Kyoto-Kameoka Study.
Hinako Nanri, Yosuke Yamada, +9 authors, Misaka Kimura.
Nutrients, 2017 Dec 16; 9(12). PMID: 29244736    Free PMC article.
The value of facial attractiveness for encouraging fruit and vegetable consumption: analyses from a randomized controlled trial.
Katherine M Appleton, Alanna J McGrath, +4 authors, Jayne V Woodside.
BMC Public Health, 2018 Mar 02; 18(1). PMID: 29490640    Free PMC article.
Put "gender glasses" on the effects of phenolic compounds on cardiovascular function and diseases.
Ilaria Campesi, Maria Marino, +2 authors, Flavia Franconi.
Eur J Nutr, 2018 Apr 27; 57(8). PMID: 29696400
Review.
Associations between dietary risk factors and ischemic stroke: a comparison of regression methods using data from the Multi-Ethnic Study of Atherosclerosis.
Seyed Saeed Hashemi Nazari, Yaser Mokhayeri, +2 authors, Hamid Soori.
Epidemiol Health, 2018 May 29; 40. PMID: 29807407    Free PMC article.
Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans.
Fred S Sarfo, Bruce Ovbiagele, +54 authors, SIREN.
Neurology, 2020 Feb 23; 94(10). PMID: 32075893    Free PMC article.
The study protocol for a pseudo-randomised pre-post designed controlled intervention trial to study the effects of a 7-week cooking program on self-efficacy and biomarkers of health: the ECU lifestyle and biomarkers get connected study (ECULABJMOF) including the Jamie's Ministry of Food WA participant experience.
Joanna Rees, Claus C Christophersen, +8 authors, Amanda Devine.
BMC Public Health, 2020 Jul 02; 20(1). PMID: 32605552    Free PMC article.
Fruit-Based Beverages Contain a Wide Range of Phytochemicals and Intervention Targets Should Account for the Individual Compounds Present and Their Availability.
Charles Bestwick, Lorraine Scobbie, +3 authors, Wendy Russell.
Foods, 2020 Jul 11; 9(7). PMID: 32645879    Free PMC article.
Association between vegetable consumption and calf venous compliance in healthy young adults.
Anna Oue, Yasuhiro Iimura, Kotose Maeda, Takahiro Yoshizaki.
J Physiol Anthropol, 2020 Aug 14; 39(1). PMID: 32787933    Free PMC article.
Dietary Adherence of Saudi Males to the Saudi Dietary Guidelines and Its Relation to Cardiovascular Diseases: A Preliminary Cross-Sectional Study.
Areej Ali Alkhaldy, Reem Saleh Alamri, +3 authors, Kamal Waheeb Alghalayini.
J Cardiovasc Dev Dis, 2019 Apr 17; 6(2). PMID: 30987347    Free PMC article.
Investigation of Cardiovascular Health and Risk Factors Among the Diverse and Contemporary Population in London (the TOGETHER Study): Protocol for Linking Longitudinal Medical Records.
Kanika Dharmayat, Maria Woringer, +7 authors, Sreenivasa Rao Kondapally Seshasai.
JMIR Res Protoc, 2020 Oct 03; 9(10). PMID: 33006568    Free PMC article.
Contrasting Effects of Short-Term Mediterranean and Vegan Diets on Microvascular Function and Cholesterol in Younger Adults: A Comparative Pilot Study.
David Rogerson, Diana Maçãs, +2 authors, Markos Klonizakis.
Nutrients, 2018 Dec 06; 10(12). PMID: 30513972    Free PMC article.
Acute Effects of Hibiscus Sabdariffa Calyces on Postprandial Blood Pressure, Vascular Function, Blood Lipids, Biomarkers of Insulin Resistance and Inflammation in Humans.
Salisu M Abubakar, Moses T Ukeyima, Jeremy P E Spencer, Julie A Lovegrove.
Nutrients, 2019 Feb 16; 11(2). PMID: 30764582    Free PMC article.