Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update

Antonio C Wolff ¹, M Elizabeth H Hammond , David G Hicks , Mitch Dowsett , Lisa M McShane , Kimberly H Allison , Donald C Allred , John M S Bartlett , Michael Bilous , Patrick Fitzgibbons , Wedad Hanna , Robert B Jenkins , Pamela B Mangu , Soonmyung Paik , Edith A Perez , Michael F Press , Patricia A Spears , Gail H Vance , Giuseppe Viale , Daniel F Hayes , American Society of Clinical Oncology , College of American Pathologists

Affiliations

¹ Antonio C. Wolff, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore; Lisa M. McShane, National Cancer Institute, Bethesda, MD; M. Elizabeth H. Hammond, University of Utah School of Medicine and Intermountain Healthcare, Salt Lake City, UT; David G. Hicks, University of Rochester Medical Center, Rochester, NY; Mitch Dowsett, Royal Marsden Hospital, London, United Kingdom; Kimberly H. Allison, Stanford University Medical Center, Stanford; Patrick Fitzgibbons, St Jude Medical Center, Fullerton; Michael F. Press, University of Southern California, Los Angeles, CA; Donald C. Allred, Washington University School of Medicine, St Louis, MO; John M.S. Bartlett, Ontario Institute for Cancer Research; Wedad Hanna, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada; Michael Bilous, University of Western Sydney and Healthscope Pathology, Sydney, New South Wales, Australia; Robert B. Jenkins, Mayo Clinic, Rochester, MN; Pamela B. Mangu, American Society of Clinical Oncology, Alexandria, VA; Soonmyung Paik, National Surgical Adjuvant Breast and Bowel Project, Pitsburgh, PA; Edith A. Perez, Mayo Clinic, Jacksonville, FL; Patricia A. Spears, North Carolina State University, Raleigh, NC; Gail H. Vance, Indiana University Medical Center, Indianapolis, IN; Giuseppe Viale, University of Milan, European Institute of Oncology, Milan, Italy; and Daniel F. Hayes, University of Michigan Comprehensive Cancer Care Center, Ann Arbor, MI.

PMID: 24099077
147 References
304 citations

Abstract

Purpose: To update the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for human epidermal growth factor receptor 2 (HER2) testing in breast cancer to improve the accuracy of HER2 testing and its utility as a predictive marker in invasive breast cancer.

Methods: ASCO/CAP convened an Update Committee that included coauthors of the 2007 guideline to conduct a systematic literature review and update recommendations for optimal HER2 testing.

Results: The Update Committee identified criteria and areas requiring clarification to improve the accuracy of HER2 testing by immunohistochemistry (IHC) or in situ hybridization (ISH). The guideline was reviewed and approved by both organizations.

Recommendations: The Update Committee recommends that HER2 status (HER2 negative or positive) be determined in all patients with invasive (early stage or recurrence) breast cancer on the basis of one or more HER2 test results (negative, equivocal, or positive). Testing criteria define HER2-positive status when (on observing within an area of tumor that amounts to >10% of contiguous and homogeneous tumor cells) there is evidence of protein overexpression (IHC) or gene amplification (HER2 copy number or HER2/CEP17 ratio by ISH based on counting at least 20 cells within the area). If results are equivocal (revised criteria), reflex testing should be performed using an alternative assay (IHC or ISH). Repeat testing should be considered if results seem discordant with other histopathologic findings. Laboratories should demonstrate high concordance with a validated HER2 test on a sufficiently large and representative set of specimens. Testing must be performed in a laboratory accredited by CAP or another accrediting entity. The Update Committee urges providers and health systems to cooperate to ensure the highest quality testing.

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Practice of HER-2 immunohistochemistry in breast carcinoma in Austria. A Reiner-Concin, P Regitnig, +5 authors, M Rudas. less Pathol Oncol Res, 2008 Aug 30; 14(3). PMID: 18752057
Application of liquid-based preparation to fine needle aspiration cytology in breast cancer. Kyoko Komatsu, Yoko Nakanishi, +6 authors, Norimichi Nemoto. less Acta Cytol, 2008 Oct 07; 52(5). PMID: 18833823
Comparison of quantitative immunofluorescence with conventional methods for HER2/neu testing with respect to response to trastuzumab therapy in metastatic breast cancer. Jennifer M Giltnane, Annette Molinaro, +5 authors, David L Rimm. less Arch Pathol Lab Med, 2008 Oct 07; 132(10). PMID: 18834223
Delineation of HER2 gene status in breast carcinoma by silver in situ hybridization is reproducible among laboratories and pathologists. Antonino Carbone, Gerardo Botti, +9 authors, Paolo Verderio. less J Mol Diagn, 2008 Oct 04; 10(6). PMID: 18832456 Free PMC article.
Polysomy 17 in breast cancer: clinicopathologic significance and impact on HER-2 testing. Isabelle Vanden Bempt, Peter Van Loo, +5 authors, Christiane De Wolf-Peeters. less J Clin Oncol, 2008 Sep 17; 26(30). PMID: 18794552
Determination of HER2 amplification by in situ hybridization: when should chromosome 17 also be determined? John M S Bartlett, Fiona M Campbell, Elizabeth A Mallon. Am J Clin Pathol, 2008 Nov 21; 130(6). PMID: 19019769
A new rabbit monoclonal antibody (4B5) for the immuno-histochemical (IHC) determination of the HER2 status in breast cancer: comparison with CB11, fluorescence in situ hybridization (FISH), and interlaboratory reproducibility. William C Powell, Patrick C Roche, Raymond R Tubbs. Appl Immunohistochem Mol Morphol, 2008 Oct 22; 16(6). PMID: 18931613
Real time RT-PCR approach for the evaluation of ERBB2 overexpression in breast cancer archival samples: a comparative study with FISH, SISH, and immunohistochemistry. Elisa Capizzi, Elisa Gruppioni, +4 authors, Michelangelo Fiorentino. less Diagn Mol Pathol, 2008 Apr 03; 17(4). PMID: 18382352
HER-2 gene amplification, HER-2 and epidermal growth factor receptor mRNA and protein expression, and lapatinib efficacy in women with metastatic breast cancer. Michael F Press, Richard S Finn, +15 authors, Maria T Koehler. less Clin Cancer Res, 2008 Dec 03; 14(23). PMID: 19047115
External quality assurance of HER2 FISH and ISH testing: three years of the UK national external quality assurance scheme. John M S Bartlett, Merdol Ibrahim, +8 authors, Keith Miller. less Am J Clin Pathol, 2008 Dec 20; 131(1). PMID: 19095573
Comprehensive immunohistochemical analysis of Her-2/neu oncoprotein overexpression in breast cancer: HercepTest (Dako) for manual testing and Her-2/neuTest 4B5 (Ventana) for Ventana BenchMark automatic staining system with correlation to results of fluorescence in situ hybridization (FISH). Doris Mayr, Sibylle Heim, +2 authors, Thomas Kirchner. less Virchows Arch, 2009 Jan 27; 454(3). PMID: 19169706
Effect of high copy number of HER2 associated with polysomy 17 on HER2 protein expression in invasive breast carcinoma. Sejal S Shah, Yan Wang, Jamie Tull, Shengle Zhang. Diagn Mol Pathol, 2009 Feb 14; 18(1). PMID: 19214111
Prediction of HER2 gene status in Her2 2+ invasive breast cancer: a study of 108 cases comparing ASCO/CAP and FDA recommendations. Frédéric Chibon, Isabelle de Mascarel, +5 authors, Gaëtan MacGrogan. less Mod Pathol, 2008 Dec 09; 22(3). PMID: 19060846
Rapid screening of tissue microarrays for Her-2 fluorescence in situ hybridization testing is an accurate, efficient and economic method of providing an entirely in situ hybridization-based Her-2 testing service. Dana Faratian, Ashley Graham, Frances Rae, Jeremy Thomas. Histopathology, 2009 Mar 25; 54(4). PMID: 19309394
Whether to determine HER2 status for breast cancer in the primary tumour or in the metastasis. M P Santiago, A Vázquez-Boquete, +5 authors, T García-Caballero. less Histol Histopathol, 2009 Apr 02; 24(6). PMID: 19337966
Fine-needle aspiration for nucleic acid-ased molecular analyses in breast cancer. Catherine Uzan, Fabrice Andre, +7 authors, Philippe Vielh. less Cancer, 2009 Apr 07; 117(1). PMID: 19347827
Even low-level HER2 expression may be associated with worse outcome in node-positive breast cancer. Michael Z Gilcrease, Wendy A Woodward, +5 authors, Thomas A Buchholz. less Am J Surg Pathol, 2009 Mar 03; 33(5). PMID: 19252432 Free PMC article.
Genetic heterogeneity in HER2 testing in breast cancer: panel summary and guidelines. Gail H Vance, Todd S Barry, +7 authors, College of American Pathologists. less Arch Pathol Lab Med, 2009 Apr 28; 133(4). PMID: 19391661
Implementation of American Society of Clinical Oncology/College of American Pathologists HER2 Guideline Recommendations in a tertiary care facility increases HER2 immunohistochemistry and fluorescence in situ hybridization concordance and decreases the number of inconclusive cases. Lavinia P Middleton, Kathy M Price, +5 authors, Michael T Deavers. less Arch Pathol Lab Med, 2009 May 07; 133(5). PMID: 19415952
The correlation between dual-color chromogenic in situ hybridization and fluorescence in situ hybridization in assessing HER2 gene amplification in breast cancer. Marianne Pedersen, Birgitte Bruun Rasmussen. Diagn Mol Pathol, 2009 May 12; 18(2). PMID: 19430295
Bright-field in situ hybridization for HER2 gene amplification in breast cancer using tissue microarrays: correlation between chromogenic (CISH) and automated silver-enhanced (SISH) methods with patient outcome. Glenn D Francis, Mark A Jones, Geoffrey F Beadle, Sandra R Stein. Diagn Mol Pathol, 2009 May 12; 18(2). PMID: 19430296
HER-2/neu analysis in breast cancer bone metastases. J Zustin, K Boddin, +9 authors, G Sauter. less J Clin Pathol, 2009 May 29; 62(6). PMID: 19474354
Automated quantitative assessment of HER-2/neu immunohistochemical expression in breast cancer. Hela Masmoudi, Stephen M Hewitt, +2 authors, Nicholas Petrick, Kyle J Myers, Marios A Gavrielides. less IEEE Trans Med Imaging, 2009 Jan 24; 28(6). PMID: 19164073 Free PMC article.
Rabbit antibodies for hormone receptors and HER2 evaluation in breast cancer. Rafael Malagoli Rocha, Cristiana Buzelin Nunes, +5 authors, Helenice Gobbi. less Rev Assoc Med Bras (1992), 2009 Jun 03; 55(2). PMID: 19488652
Development of an unsupervised pixel-based clustering algorithm for compartmentalization of immunohistochemical expression using Automated QUantitative Analysis. Mark D Gustavson, Brian Bourke-Martin, +5 authors, Jason Christiansen. less Appl Immunohistochem Mol Morphol, 2009 Mar 26; 17(4). PMID: 19318915
Disease-free survival according to degree of HER2 amplification for patients treated with adjuvant chemotherapy with or without 1 year of trastuzumab: the HERA Trial. Mitch Dowsett, Marion Procter, +11 authors, Brian Leyland-Jones. less J Clin Oncol, 2009 Apr 15; 27(18). PMID: 19364966 Free PMC article.
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Antonio C Wolff, M Elizabeth H Hammond, +21 authors, American Society of Clinical Oncology/College of American Pathologists. less Arch Pathol Lab Med, 2007 Jan 01; 131(1). PMID: 19548375 Highly Cited.
Performance of chromogenic in situ hybridization on testing HER2 Status in breast carcinomas with chromosome 17 polysomy and equivocal (2+) herceptest results: a study of two institutions using the conventional and new ASCO/CAP scoring criteria. Yun Gong, William Sweet, +6 authors, Nour Sneige. less Am J Clin Pathol, 2009 Jul 17; 132(2). PMID: 19605817
Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis. Caterina Marchiò, Maryou B Lambros, +11 authors, Anna Sapino. less J Pathol, 2009 Aug 12; 219(1). PMID: 19670217
Immunohistochemical detection of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression in breast carcinomas: comparison on cell block, needle-core, and tissue block preparations. Krisztina Z Hanley, George G Birdsong, Cynthia Cohen, Momin T Siddiqui. Cancer, 2009 Jun 25; 117(4). PMID: 19551847
Clinical validation of an array CGH test for HER2 status in breast cancer reveals that polysomy 17 is a rare event. I-Tien Yeh, Mathew A Martin, +6 authors, Shelly R Gunn. less Mod Pathol, 2009 May 19; 22(9). PMID: 19448591
Comparison of fluorescent in situ hybridization HER-2/neu results on core needle biopsy and excisional biopsy in primary breast cancer. Sophia K Apple, Alarice C Lowe, +2 authors, P Nagesh Rao, I Peter Shintaku, Neda A Moatamed. less Mod Pathol, 2009 Jun 02; 22(9). PMID: 19483670
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Automated cellular imaging system III for assessing HER2 status in breast cancer specimens: development of a standardized scoring method that correlates with FISH. Douglas M Minot, Benjamin R Kipp, +5 authors, Amy C Clayton. less Am J Clin Pathol, 2009 Oct 30; 132(1). PMID: 19864244
Delay to formalin fixation effect on breast biomarkers. Thaer Khoury, Sheila Sait, +4 authors, Swati Kulkarni. less Mod Pathol, 2009 Sep 08; 22(11). PMID: 19734848
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Estimation of hormone receptor status and HER2 in cytologic cell blocks from breast cancer using the novel rabbit monoclonal antibodies (SP1, SP2, and SP3). Aziza Nassar, Cynthia Cohen, Momin Siddiqui. Diagn Cytopathol, 2009 Jun 17; 37(12). PMID: 19530101
Microarray-based determination of estrogen receptor, progesterone receptor, and HER2 receptor status in breast cancer. Paul Roepman, Hugo M Horlings, +6 authors, Marc J van de Vijver. less Clin Cancer Res, 2009 Nov 06; 15(22). PMID: 19887485
Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancer. Weiguo Sui, Minglin Ou, +5 authors, Yong Dai. less World J Surg Oncol, 2009 Nov 10; 7. PMID: 19895711 Free PMC article.
Discordance between core needle biopsy (CNB) and excisional biopsy (EB) for estrogen receptor (ER), progesterone receptor (PgR) and HER2 status in early breast cancer (EBC). M Arnedos, A Nerurkar, +3 authors, P Osin, R A'Hern, I E Smith, M Dowsett. less Ann Oncol, 2009 Jul 03; 20(12). PMID: 19570962
Loss of HER2 amplification following trastuzumab-based neoadjuvant systemic therapy and survival outcomes. Elizabeth A Mittendorf, Yun Wu, +10 authors, Ana M Gonzalez-Angulo. less Clin Cancer Res, 2009 Nov 19; 15(23). PMID: 19920100 Free PMC article.
Chromogenic in situ hybridization for Her-2/neu-oncogene in breast cancer: comparison of a new dual-colour chromogenic in situ hybridization with immunohistochemistry and fluorescence in situ hybridization. Doris Mayr, Sibylle Heim, +4 authors, Thomas Kirchner. less Histopathology, 2009 Nov 20; 55(6). PMID: 19922593
HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial. Edith A Perez, Monica M Reinholz, +14 authors, Robert B Jenkins. less J Clin Oncol, 2010 Aug 11; 28(28). PMID: 20697084 Free PMC article.
Human epidermal growth factor receptor 2 assessment in a case-control study: comparison of fluorescence in situ hybridization and quantitative reverse transcription polymerase chain reaction performed by central laboratories. Frederick L Baehner, Ninah Achacoso, +5 authors, Laurel A Habel. less J Clin Oncol, 2010 Aug 11; 28(28). PMID: 20697093
HER2 status in a population-derived breast cancer cohort: discordances during tumor progression. Ulla Wilking, Eva Karlsson, +6 authors, Jonas Bergh. less Breast Cancer Res Treat, 2010 Jul 16; 125(2). PMID: 20628810
A UK NEQAS ISH multicenter ring study using the Ventana HER2 dual-color ISH assay. J M S Bartlett, Fiona M Campbell, +8 authors, Keith Miller. less Am J Clin Pathol, 2010 Dec 22; 135(1). PMID: 21173138

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Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women. Bruna Sugita, Mandeep Gill, +16 authors, Luciane R Cavalli. less Oncotarget, 2016 Nov 05; 7(48). PMID: 27813494 Free PMC article.
HER2 mRNA transcript quantitation in breast cancer. K Meehan, B Clynick, +3 authors, B Mirzai, P Maslen, J M Harvey, W N Erber. less Clin Transl Oncol, 2016 Nov 12; 19(5). PMID: 27837339
Prognostic significance of mucin expression profiles in breast carcinoma with signet ring cells: a clinicopathological study. Ryuji Ohashi, Ayako Hayama, +4 authors, Zenya Naito. less Diagn Pathol, 2016 Nov 17; 11(1). PMID: 27846863 Free PMC article.
Application of the downgrade criteria to supplemental screening ultrasound for women with negative mammography but dense breasts. Soo-Yeon Kim, Min Jung Kim, +2 authors, Hee Jung Moon, Jung Hyun Yoon, Eun-Kyung Kim. less Medicine (Baltimore), 2016 Nov 20; 95(44). PMID: 27858896 Free PMC article.
Comparison of immunophenotypes of primary breast carcinomas and multiple corresponding distant metastases: an autopsy study of 25 patients. B Szekely, Zs I Nagy, +13 authors, J Kulka. less Clin Exp Metastasis, 2016 Nov 26; 34(1). PMID: 27885435
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FISH testing of HER2 immunohistochemistry 1+ invasive breast cancer with unfavorable characteristics. Stella Petroni, Lucia Caldarola, +4 authors, Giovanni Simone. less Oncol Lett, 2016 Dec 03; 12(5). PMID: 27899970 Free PMC article.
Detection of gene copy number alterations in DCIS and invasive breast cancer by QM-FISH. Aifeng Pan, Yawei Zhou, +4 authors, Li Li. less Am J Transl Res, 2016 Dec 03; 8(11). PMID: 27904700 Free PMC article.
Generation, characterization, and maintenance of trastuzumab-resistant HER2+ breast cancer cell lines. Sandra Zazo, Paula González-Alonso, +9 authors, Federico Rojo. less Am J Cancer Res, 2016 Dec 03; 6(11). PMID: 27904779 Free PMC article.
An mRNA Gene Expression-Based Signature to Identify FGFR1-Amplified Estrogen Receptor-Positive Breast Tumors. Jingqin Luo, Shuzhen Liu, +11 authors, Matthew J Ellis. less J Mol Diagn, 2016 Dec 21; 19(1). PMID: 27993329 Free PMC article.
Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Lacey E Dobrolecki, Susie D Airhart, +29 authors, Michael T Lewis. less Cancer Metastasis Rev, 2016 Dec 28; 35(4). PMID: 28025748 Free PMC article. Highly Cited. Review.
Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines. Sollip Kim, Yeo Min Yun, +9 authors, Sail Chun. less Ann Lab Med, 2016 Dec 29; 37(2). PMID: 28029011 Free PMC article.
Heterogeneous expression of PD-L1 in pulmonary squamous cell carcinoma and adenocarcinoma: implications for assessment by small biopsy. Thomas J Gniadek, Qing Kay Li, +3 authors, Edward Gabrielson. less Mod Pathol, 2017 Jan 07; 30(4). PMID: 28059094
HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. Angela N Bartley, Mary Kay Washington, +12 authors, Jaffer A Ajani. less Am J Clin Pathol, 2017 Jan 13; 146(6). PMID: 28077399 Free PMC article. Systematic Review.
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The neutrophil-to-lymphocyte ratio: a narrative review. Sara Socorro Faria, Paulo César Fernandes, +5 authors, Patrice Forget. less Ecancermedicalscience, 2017 Jan 21; 10. PMID: 28105073 Free PMC article. Highly Cited. Review.
Progressive APOBEC3B mRNA expression in distant breast cancer metastases. Anieta M Sieuwerts, Willemijne A M E Schrijver, +6 authors, Carolien H M van Deurzen. less PLoS One, 2017 Feb 01; 12(1). PMID: 28141868 Free PMC article.
The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas. Charlotte K Y Ng, Salvatore Piscuoglio, +12 authors, Jorge S Reis-Filho. less Clin Cancer Res, 2017 Feb 06; 23(14). PMID: 28153863 Free PMC article. Highly Cited.
Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes. Joo Young Kim, Sun-Hee Heo, +8 authors, Hee Jin Lee. less Virchows Arch, 2017 Feb 12; 470(4). PMID: 28185053
Treatment Outcomes and Clinicopathologic Characteristics of Triple-Negative Breast Cancer: A Report from Cancer Institute of Iran. Mehrzad Mirzania, Seyed Reza Safaee, +3 authors, Reza Mehdizadeh. less Int J Hematol Oncol Stem Cell Res, 2017 Mar 14; 11(1). PMID: 28286613 Free PMC article.
Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay. Thaddeus S Block, Tiffany I Murphy, +2 authors, Pamela N Munster, Dat P Nguyen, Frank J Lynch. less Cancer Manag Res, 2017 Mar 16; 9. PMID: 28293120 Free PMC article.
The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Silvia Grasso, Jennifer Chapelle, +28 authors, Paola Defilippi. less Nat Commun, 2017 Mar 17; 8. PMID: 28300085 Free PMC article.
Performance of Mid-Treatment Breast Ultrasound and Axillary Ultrasound in Predicting Response to Neoadjuvant Chemotherapy by Breast Cancer Subtype. Rosalind P Candelaria, Roland L Bassett, +5 authors, Wei Tse Yang. less Oncologist, 2017 Mar 21; 22(4). PMID: 28314842 Free PMC article.
Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer. Mesut Öztürk, Ahmet Veysel Polat, +2 authors, Yurdanur Süllü, Leman Tomak, Ayfer Kamalı Polat. less J Breast Health, 2017 Mar 24; 13(1). PMID: 28331765 Free PMC article.
Relevance of deep learning to facilitate the diagnosis of HER2 status in breast cancer. Michel E Vandenberghe, Marietta L J Scott, +3 authors, Craig Barker. less Sci Rep, 2017 Apr 06; 7. PMID: 28378829 Free PMC article.
A Microfluidic Immunostaining System Enables Quality Assured and Standardized Immunohistochemical Biomarker Analysis. Seyong Kwon, Chang Hyun Cho, +2 authors, Youngmee Kwon, Eun Sook Lee, Je-Kyun Park. less Sci Rep, 2017 Apr 06; 7. PMID: 28378835 Free PMC article.
Clinicopathologic study of invasive micropapillary carcinoma of the breast. Shen-Li Tang, Ji-Qiao Yang, +4 authors, Qing Lv. less Oncotarget, 2017 Apr 19; 8(26). PMID: 28418916 Free PMC article.
Quantification of HER2 and estrogen receptor heterogeneity in breast cancer by single-molecule RNA fluorescence in situ hybridization. Laura Annaratone, Michele Simonetti, +7 authors, Nicola Crosetto. less Oncotarget, 2017 Apr 21; 8(12). PMID: 28423635 Free PMC article.
CKS1BP7, a Pseudogene of CKS1B, is Co-Amplified with IGF1R in Breast Cancers. Yansong Liu, Wei Wang, +3 authors, Yan Li, Feifei Sun, Jiaxiang Lin, Li Li. less Pathol Oncol Res, 2017 Apr 26; 24(2). PMID: 28439706
Human epidermal growth factor receptor 2 expression is more important than Bacillus Calmette Guerin treatment in predicting the outcome of T1G3 bladder cancer. Luigi Cormio, Francesca Sanguedolce, +7 authors, Pantaleo Bufo. less Oncotarget, 2017 Apr 28; 8(15). PMID: 28445991 Free PMC article.
Chromobox homolog 2 protein: A novel biomarker for predicting prognosis and Taxol sensitivity in patients with breast cancer. Wang Yang Chen, Xian Yu Zhang, +3 authors, Tong Liu, Yang Liu, Ya Shuang Zhao, Da Pang. less Oncol Lett, 2017 Apr 30; 13(3). PMID: 28454227 Free PMC article.
Serum Metabolomic Profiles for Breast Cancer Diagnosis, Grading and Staging by Gas Chromatography-Mass Spectrometry. Naila Irum Hadi, Qamar Jamal, +3 authors, Syed Ghulam Musharraf. less Sci Rep, 2017 May 13; 7(1). PMID: 28496143 Free PMC article.
Annexin A3 as a Prognostic Biomarker for Breast Cancer: A Retrospective Study. Tao Zhou, Yong Li, +3 authors, Li Yang, Tiantian Tang, Lina Zhang, Jiajie Shi. less Biomed Res Int, 2017 May 13; 2017. PMID: 28497041 Free PMC article.
Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer. Wataru Goto, Shinichiro Kashiwagi, +9 authors, Masaichi Ohira. less Biomark Res, 2017 May 17; 5. PMID: 28507762 Free PMC article.
Invasive lobular carcinoma with extracellular mucin production-a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases. Gábor Cserni, Giuseppe Floris, +5 authors, Zsuzsanna Varga. less Virchows Arch, 2017 May 22; 471(1). PMID: 28528509
Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research. Sibylle Baechmann, Steffen Ormanns, +8 authors, Stefan Boeck. less BMC Cancer, 2017 May 28; 17(1). PMID: 28549417 Free PMC article.
Comparison of HER2 amplification status among breast cancer subgroups offers new insights in pathways of breast cancer progression. Kathleen Lambein, Mieke Van Bockstal, +5 authors, Louis Libbrecht. less Virchows Arch, 2017 Jun 02; 471(5). PMID: 28567637
Correlation Between Preoperative Serum Carcinoembryonic Antigen Levels and Expression on Pancreatic and Rectal Cancer Tissue. L S F Boogerd, F A Vuijk, +8 authors, Alexander L Vahrmeijer. less Biomark Cancer, 2017 Jun 06; 9. PMID: 28579847 Free PMC article.
Molecular characterization of breast cancer cell lines by clinical immunohistochemical markers. André de Lima Mota, Adriane Feijo Evangelista, +4 authors, Marcia Maria Chiquitelli Marques. less Oncol Lett, 2017 Jun 08; 13(6). PMID: 28588725 Free PMC article.
Prognostic Significance of a Micropapillary Pattern in Pure Mucinous Carcinoma of the Breast: Comparative Analysis with Micropapillary Carcinoma. Hyun-Jung Kim, Kyeongmee Park, +3 authors, Inseok Park. less J Pathol Transl Med, 2017 Jun 10; 51(4). PMID: 28597867 Free PMC article.
Age-associated prognostic and predictive biomarkers in patients with breast cancer. Markéta Kolečková, Zdeněk Kolář, +2 authors, Radek Trojanec. less Oncol Lett, 2017 Jun 11; 13(6). PMID: 28599421 Free PMC article.
Cone-beam Breast Computed Tomography: CT Density Does Not Reflect Proliferation Potential and Receptor Expression of Breast Carcinoma. Susanne Wienbeck, Uwe Fischer, +4 authors, Alexey Surov. less Transl Oncol, 2017 Jul 01; 10(4). PMID: 28666188 Free PMC article.
Impact of RASSF1A gene methylation on the metastatic axillary nodal status in breast cancer patients. Eva Jezkova, Pavol Zubor, +6 authors, Jan Danko. less Oncol Lett, 2017 Jul 12; 14(1). PMID: 28693231 Free PMC article.
Variability in DNA Repair Capacity Levels among Molecular Breast Cancer Subtypes: Triple Negative Breast Cancer Shows Lowest Repair. Jaime Matta, Carmen Ortiz, +2 authors, Jarline Encarnación, Julie Dutil, Erick Suárez. less Int J Mol Sci, 2017 Jul 15; 18(7). PMID: 28704967 Free PMC article.
Whole tumor section quantitative image analysis maximizes between-pathologists' reproducibility for clinical immunohistochemistry-based biomarkers. Michael Barnes, Chukka Srinivas, +11 authors, Jim Ranger-Moore. less Lab Invest, 2017 Aug 15; 97(12). PMID: 28805805
Regional Variability in Percentage of Breast Cancers Reported as Positive for HER2 in California: Implications of Patient Demographics on Laboratory Benchmarks. Chieh-Yu Lin, Eugene E Carneal, +5 authors, Kimberly H Allison. less Am J Clin Pathol, 2017 Aug 20; 148(3). PMID: 28821197 Free PMC article.
Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach? Pavol Zubor, Alexandra Gondova, +4 authors, Olga Golubnitschaja. less EPMA J, 2017 Aug 22; 8(2). PMID: 28824738 Free PMC article.
Country and regional variations in purchase prices for essential cancer medications. Raphael E Cuomo, Robert L Seidman, Tim K Mackey. BMC Cancer, 2017 Aug 25; 17(1). PMID: 28836947 Free PMC article.
Validation of Immunohistochemical Assays for Integral Biomarkers in the NCI-MATCH EAY131 Clinical Trial. Joseph D Khoury, Wei-Lien Wang, +5 authors, Stanley R Hamilton. less Clin Cancer Res, 2017 Aug 26; 24(3). PMID: 28839110 Free PMC article. Review.
A novel treatment approach for retinoblastoma by targeting epithelial growth factor receptor expression with a shRNA lentiviral system. Yong Chai, Juhua Xiao, +4 authors, Kai Huang. less Iran J Basic Med Sci, 2017 Aug 31; 20(7). PMID: 28852437 Free PMC article.
Separase is a marker for prognosis and mitotic activity in breast cancer. Natalia Gurvits, Eliisa Löyttyniemi, +3 authors, Kati Talvinen. less Br J Cancer, 2017 Sep 01; 117(9). PMID: 28859055 Free PMC article.
BRCA1 protein expression and subcellular localization in primary breast cancer: Automated digital microscopy analysis of tissue microarrays. Abeer M Mahmoud, Virgilia Macias, +4 authors, Garth H Rauscher. less PLoS One, 2017 Sep 02; 12(9). PMID: 28863181 Free PMC article.
High concordance of a closed-system, RT-qPCR breast cancer assay for HER2 mRNA, compared to clinically determined immunohistochemistry, fluorescence in situ hybridization, and quantitative immunofluorescence. Brad E Wasserman, Daniel E Carvajal-Hausdorf, +8 authors, David L Rimm. less Lab Invest, 2017 Sep 12; 97(12). PMID: 28892092 Free PMC article.
Evaluation of Partial Breast Reirradiation with Intraoperative Radiotherapy after Prior Thoracic Radiation: A Single-Institution Report of Outcomes and Toxicity. Christine Chin, Priya Jadeja, +4 authors, Eileen P Connolly. less Front Oncol, 2017 Sep 13; 7. PMID: 28894694 Free PMC article.
The early onset of peripheral neuropathy might be a robust predictor for time to treatment failure in patients with metastatic breast cancer receiving chemotherapy containing paclitaxel. Ippei Fukada, Yoshinori Ito, +6 authors, Shinji Ohno. less PLoS One, 2017 Sep 13; 12(9). PMID: 28898275 Free PMC article.
Clinicopathological study of a dimorphic variant of breast carcinoma. Nozomi Ueno, Hajime Kuroda, +5 authors, Yasuo Imai. less Breast Cancer, 2017 Oct 02; 25(2). PMID: 28965222 Free PMC article.
Discovery of NKCC1 as a potential therapeutic target to inhibit hepatocellular carcinoma cell growth and metastasis. Yaya Zhou, Wei Sun, +10 authors, Ying Jiang. less Oncotarget, 2017 Oct 17; 8(39). PMID: 29029515 Free PMC article.
Overview on Patient Centricity in Cancer Care. Šarunas Narbutas, Kristina York, +5 authors, Andras Inotai. less Front Pharmacol, 2017 Oct 21; 8. PMID: 29051734 Free PMC article.
Canine invasive mammary carcinomas as models of human breast cancer. Part 2: immunophenotypes and prognostic significance. Jérôme Abadie, Frédérique Nguyen, +8 authors, Mario Campone. less Breast Cancer Res Treat, 2017 Oct 25; 167(2). PMID: 29063312 Free PMC article.
Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors. Frédérique Nguyen, Laura Peña, +6 authors, Jérôme Abadie. less Breast Cancer Res Treat, 2017 Nov 01; 167(3). PMID: 29086231 Free PMC article.
Downregulation of TAP1 and TAP2 in early stage breast cancer. Andrea M Henle, Aziza Nassar, +2 authors, Keith L Knutson. less PLoS One, 2017 Nov 02; 12(11). PMID: 29091951 Free PMC article.
Comparative Evaluation of Anti-HER2 Affibody Molecules Labeled with 64Cu Using NOTA and NODAGA. Vladimir Tolmachev, Cheng-Bin Yim, +6 authors, Anna Orlova. less Contrast Media Mol Imaging, 2017 Nov 04; 2017. PMID: 29097939 Free PMC article.
A Retrospective Analysis of Clinical Utility of AJCC 8th Edition Cancer Staging System for Breast Cancer. Hui Hu, Wei Wei, +2 authors, Xin Yi, Ling Xin, Yinhua Liu. less World J Oncol, 2017 Nov 18; 8(3). PMID: 29147438 Free PMC article.
MiR-1268b confers chemosensitivity in breast cancer by targeting ERBB2-mediated PI3K-AKT pathway. Wen-Jie Zhu, Xu Chen, +3 authors, Peng Gao. less Oncotarget, 2017 Nov 23; 8(52). PMID: 29163776 Free PMC article.
Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery. Connor W Barth, Jasmin M Schaefer, +2 authors, Vincent M Rossi, Scott C Davis, Summer L Gibbs. less Theranostics, 2017 Dec 01; 7(19). PMID: 29187899 Free PMC article.
Role of HER-2/neu in Premalignant and Malignant Lesions of Uterine Cervix. Swasti Bajpai, Seema Awasthi, +3 authors, Faiyaz Ahmad. less J Clin Diagn Res, 2017 Dec 07; 11(9). PMID: 29207712 Free PMC article.
Clinical and Epidemiological Profile of Breast Cancer in Mexico: Results of the Seguro Popular. Nancy Reynoso-Noverón, Cynthia Villarreal-Garza, +9 authors, Alejandro Mohar. less J Glob Oncol, 2017 Dec 16; 3(6). PMID: 29244990 Free PMC article.
Challenges and future of biomarker tests in the era of precision oncology: Can we rely on immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to select the optimal patients for matched therapy? Young Kwang Chae, Ayush Arya, +9 authors, Francis Giles. less Oncotarget, 2017 Dec 17; 8(59). PMID: 29246028 Free PMC article. Review.
Protein biomarkers for subtyping breast cancer and implications for future research. Claudius Mueller, Amanda Haymond, +2 authors, Justin B Davis, Alexa Williams, Virginia Espina. less Expert Rev Proteomics, 2017 Dec 23; 15(2). PMID: 29271260 Free PMC article. Review.
Prognostic parameters of luminal A and luminal B intrinsic breast cancer subtypes of Pakistani patients. Atif Ali Hashmi, Saher Aijaz, +8 authors, Amir Khan. less World J Surg Oncol, 2018 Jan 03; 16(1). PMID: 29291744 Free PMC article.
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast. Sung-Im Do, Hyun-Soo Kim, +5 authors, Jin Hee Sohn. less Am J Transl Res, 2018 Jan 10; 9(12). PMID: 29312521 Free PMC article.
Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas. Jasmina Topcagic, Rebecca Feldman, +3 authors, Semir Vranic. less PLoS One, 2018 Jan 13; 13(1). PMID: 29324814 Free PMC article.
High expression of PU.1 is associated with Her-2 and shorter survival in patients with breast cancer. Jing Lin, Wei Liu, +7 authors, Lihong Wang. less Oncol Lett, 2018 Jan 19; 14(6). PMID: 29344265 Free PMC article.
Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer. Hee Jin Lee, Young-Ae Kim, +16 authors, Gyungyub Gong. less Oncotarget, 2018 Jan 27; 8(69). PMID: 29371915 Free PMC article.
Contrast-enhanced MRI after neoadjuvant chemotherapy of breast cancer: lesion-to-background parenchymal signal enhancement ratio for discriminating pathological complete response from minimal residual tumour. Soo-Yeon Kim, Nariya Cho, +8 authors, Woo Kyung Moon. less Eur Radiol, 2018 Jan 31; 28(7). PMID: 29380033
Analysis of tumour-infiltrating lymphocytes reveals two new biologically different subgroups of breast ductal carcinoma in situ. Marie Beguinot, Marie-Melanie Dauplat, +5 authors, Nina Radosevic-Robin. less BMC Cancer, 2018 Feb 06; 18(1). PMID: 29394917 Free PMC article.
PD-L1 diagnostic tests: a systematic literature review of scoring algorithms and test-validation metrics. Margarita Udall, Maria Rizzo, +4 authors, Eric Faulkner. less Diagn Pathol, 2018 Feb 11; 13(1). PMID: 29426340 Free PMC article. Highly Cited. Systematic Review.
Improving accuracy of breast cancer biomarker testing in India. Tanuja Shet. Indian J Med Res, 2018 Feb 13; 146(4). PMID: 29434058 Free PMC article. Review.
Clinical significance of quantitative HER2 gene amplification as related to its predictive value in breast cancer patients in neoadjuvant setting. Ziping Wu, Shuguang Xu, +8 authors, Jinsong Lu. less Onco Targets Ther, 2018 Mar 03; 11. PMID: 29497312 Free PMC article.
Prognostic implications of HER2 heterogeneity in gastric cancer. Shigenobu Motoshima, Koji Yonemoto, +2 authors, Hideki Kamei, Michi Morita, Rin Yamaguchi. less Oncotarget, 2018 Mar 07; 9(10). PMID: 29507688 Free PMC article.
The role of programmed death ligand-1 and tumor-infiltrating lymphocytes in breast cancer overexpressing HER2 gene. Yanchun Li, Mateusz Opyrchal, +4 authors, Thaer Khoury. less Breast Cancer Res Treat, 2018 Mar 11; 170(2). PMID: 29524062 Free PMC article.
Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes. Valeriy Domenyuk, Zoran Gatalica, +26 authors, David Spetzler. less Nat Commun, 2018 Mar 25; 9(1). PMID: 29572535 Free PMC article.
Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect. Asim Jamal Shaikh, Maeve Mullooly, +6 authors, Gretchen L Gierach. less Biomed Res Int, 2018 Apr 03; 2018. PMID: 29607324 Free PMC article.
Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer. Chih-Hsing Hung, Fang-Ming Chen, +5 authors, Ming-Feng Hou. less BMC Cancer, 2018 Apr 05; 18(1). PMID: 29614988 Free PMC article.
MRI-based response patterns during neoadjuvant chemotherapy can predict pathological (complete) response in patients with breast cancer. Briete Goorts, Kelly M A Dreuning, +5 authors, Marjolein L Smidt. less Breast Cancer Res, 2018 Apr 20; 20(1). PMID: 29669584 Free PMC article.
Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma. Michele Simbolo, Caterina Vicentini, +15 authors, Aldo Scarpa. less Sci Rep, 2018 May 10; 8(1). PMID: 29740198 Free PMC article.
The Association between Molecular Subtypes of Breast Cancer with Histological Grade and Lymph Node Metastases in Indonesian Woman Yunita Setyawati, Yeni Rahmawati, +2 authors, Irianiwati Widodo, Ahmad Ghozali, Dewajani Purnomosari. less Asian Pac J Cancer Prev, 2018 May 29; 19(5). PMID: 29801411 Free PMC article.
Clinical significance of androgen receptor expression in triple negative breast cancer-an immunohistochemistry study. Ya-Xuan Liu, Ke-Jing Zhang, Li-Li Tang. Oncol Lett, 2018 May 31; 15(6). PMID: 29844843 Free PMC article.
Identifying an early treatment window for predicting breast cancer response to neoadjuvant chemotherapy using immunohistopathology and hemoglobin parameters. Quing Zhu, Susan Tannenbaum, +10 authors, Kert Sabbath. less Breast Cancer Res, 2018 Jun 15; 20(1). PMID: 29898762 Free PMC article.
High Densities of Tumor-Associated Plasma Cells Predict Improved Prognosis in Triple Negative Breast Cancer. Joe Yeong, Jeffrey Chun Tatt Lim, +10 authors, Jabed Iqbal. less Front Immunol, 2018 Jun 15; 9. PMID: 29899747 Free PMC article.
LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases. Amanda E D Van Swearingen, Marni B Siegel, +21 authors, Carey K Anders. less Breast Cancer Res Treat, 2018 Jun 26; 171(3). PMID: 29938395 Free PMC article.
Outcome of inflammatory breast cancer in Moroccan patients: clinical, molecular and pathological characteristics of 219 cases from the National Oncology Institute (INO). Meriem Slaoui, Abdou Azaque Zoure, +4 authors, Mariam Amrani. less BMC Cancer, 2018 Jul 07; 18(1). PMID: 29976157 Free PMC article.
The association of genomic lesions and PD-1/PD-L1 expression in resected triple-negative breast cancers. Michael T Barrett, Elizabeth Lenkiewicz, +10 authors, Barbara A Pockaj. less Breast Cancer Res, 2018 Jul 13; 20(1). PMID: 29996881 Free PMC article.
Associations of angiogenesis-related proteins with specific prognostic factors, breast cancer subtypes and survival outcome in early-stage breast cancer patients. A Hellenic Cooperative Oncology Group (HeCOG) trial. Anna Goussia, Nafsika Simou, +24 authors, Anna Batistatou. less PLoS One, 2018 Aug 01; 13(7). PMID: 30063723 Free PMC article.
Clinicopathologic features of invasive metaplastic and micropapillary breast carcinoma: comparison with invasive ductal carcinoma of breast. Atif Ali Hashmi, Saher Aijaz, +8 authors, Amir Khan. less BMC Res Notes, 2018 Aug 02; 11(1). PMID: 30064485 Free PMC article.
Subtyping Of Triple Negative Breast Carcinoma On The Basis Of RTK Expression. Harald Hessel, Manuela Poignée-Heger, +6 authors, Thomas Kirchner. less J Cancer, 2018 Aug 09; 9(15). PMID: 30087699 Free PMC article.
APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer. Yoshitaka Fujiki, Yutaka Yamamoto, +5 authors, Hirotaka Iwase. less Oncotarget, 2018 Aug 11; 9(55). PMID: 30093965 Free PMC article.
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Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers. Lenka Kalinkova, Iveta Zmetakova, +6 authors, Ivana Fridrichova. less BMC Cancer, 2018 Sep 08; 18(1). PMID: 30189837 Free PMC article.
Immunoexpression of claudins 4 and 7 among invasive breast carcinoma subtypes: A large diagnostic study using tissue microarray. Angela Flávia Logullo, Fatima Solange Pasini, +3 authors, Maria Mitzi Brentani. less Mol Clin Oncol, 2018 Sep 15; 9(4). PMID: 30214726 Free PMC article.
Intravoxel incoherent motion magnetic resonance imaging for breast cancer: A comparison with benign lesions and evaluation of heterogeneity in different tumor regions with prognostic factors and molecular classification. Ming Zhao, Kuang Fu, +6 authors, Jiawei Tian. less Oncol Lett, 2018 Sep 27; 16(4). PMID: 30250578 Free PMC article.
The Prognostic Impact of Synchronous Ipsilateral Multiple Breast Cancer: Survival Outcomes according to the Eighth American Joint Committee on Cancer Staging and Molecular Subtype. Jinah Chu, Hyunsik Bae, +3 authors, Eun Yoon Cho. less J Pathol Transl Med, 2018 Oct 24; 52(6). PMID: 30347971 Free PMC article.
Quantitative assessment of metabolic tumor burden in molecular subtypes of primary breast cancer with FDG PET/CT. Wei Chen, Lei Zhu, +3 authors, Xiaozhou Yu, Qiang Fu, Wengui Xu, Ping Wang. less Diagn Interv Radiol, 2018 Nov 09; 24(6). PMID: 30406761 Free PMC article.
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Y-Box binding protein 1 expression in breast cancer and its correlation with hormone receptors and other prognostic markers. Taruna Bansal, Nadeem Tanveer, +2 authors, Usha Rani Singh, Sonal Sharma, Navneet Kaur. less J Lab Physicians, 2018 Dec 01; 10(4). PMID: 30498315 Free PMC article.
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