Journal Article
. 2013 Nov; 45(12):1446-51.
doi: 10.1038/ng.2823.

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

Dan R Robinson 1 Yi-Mi Wu  Pankaj Vats  Fengyun Su  Robert J Lonigro  Xuhong Cao  Shanker Kalyana-Sundaram  Rui Wang  Yu Ning  Lynda Hodges  Amy Gursky  Javed Siddiqui  Scott A Tomlins  Sameek Roychowdhury  Kenneth J Pienta  Scott Y Kim  J Scott Roberts  James M Rae  Catherine H Van Poznak  Daniel F Hayes  Rashmi Chugh  Lakshmi P Kunju  Moshe Talpaz  Anne F Schott  Arul M Chinnaiyan  
Affiliations
  • PMID: 24185510
  •     40 References
  •     405 citations

Abstract

Breast cancer is the most prevalent cancer in women, and over two-thirds of cases express estrogen receptor-α (ER-α, encoded by ESR1). Through a prospective clinical sequencing program for advanced cancers, we enrolled 11 patients with ER-positive metastatic breast cancer. Whole-exome and transcriptome analysis showed that six cases harbored mutations of ESR1 affecting its ligand-binding domain (LBD), all of whom had been treated with anti-estrogens and estrogen deprivation therapies. A survey of The Cancer Genome Atlas (TCGA) identified four endometrial cancers with similar mutations of ESR1. The five new LBD-localized ESR1 mutations identified here (encoding p.Leu536Gln, p.Tyr537Ser, p.Tyr537Cys, p.Tyr537Asn and p.Asp538Gly) were shown to result in constitutive activity and continued responsiveness to anti-estrogen therapies in vitro. Taken together, these studies suggest that activating mutations in ESR1 are a key mechanism in acquired endocrine resistance in breast cancer therapy.

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Jiaxin Niu, Grant Andres, +7 authors, Maurie Markman.
Onco Targets Ther, 2015 Dec 10; 8. PMID: 26648736    Free PMC article.
Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Cancer Types Using a Structural Genomics-based Approach.
Junfei Zhao, Feixiong Cheng, +2 authors, Zhongming Zhao.
Mol Cell Proteomics, 2015 Dec 15; 15(2). PMID: 26657081    Free PMC article.
Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer.
Tommaso De Marchi, Anne M Timmermans, +12 authors, Arzu Umar.
Oncotarget, 2015 Dec 15; 7(3). PMID: 26657294    Free PMC article.
ESR1 Mutations in Breast Cancer: Proof-of-Concept Challenges Clinical Action.
Guowei Gu, Suzanne A W Fuqua.
Clin Cancer Res, 2015 Dec 25; 22(5). PMID: 26700205    Free PMC article.
Cell-free circulating tumour DNA as a liquid biopsy in breast cancer.
Leticia De Mattos-Arruda, Carlos Caldas.
Mol Oncol, 2016 Jan 19; 10(3). PMID: 26776681    Free PMC article.
Review.
CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression.
Partha Mitra, Ren-Ming Yang, +2 authors, Thomas J Gonda.
Oncotarget, 2016 Jan 27; 7(8). PMID: 26812885    Free PMC article.
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Sean W Fanning, Christopher G Mayne, +13 authors, Geoffrey L Greene.
Elife, 2016 Feb 03; 5. PMID: 26836308    Free PMC article.
Highly Cited.
A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.
Ahmet Acar, Bruno M Simões, Robert B Clarke, Keith Brennan.
Stem Cells Int, 2016 Feb 18; 2016. PMID: 26880941    Free PMC article.
Review.
Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer.
J S Carroll.
Eur J Endocrinol, 2016 Feb 18; 175(1). PMID: 26884552    Free PMC article.
Review.
ELF5 and DOK7 regulation in anti-estrogen treated cells and tumors.
Lily M Fitzgerald, Eva P Browne, +7 authors, Kathleen F Arcaro.
Cancer Cell Int, 2016 Feb 18; 16. PMID: 26884724    Free PMC article.
Personalizing Medicine in Head and Neck Squamous Cell Carcinoma: The Rationale for Combination Therapies.
Andrew C Birkeland, J Chad Brenner.
Med Res Arch, 2016 Feb 26; 3. PMID: 26913293    Free PMC article.
Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
Thomas E Speltz, Sean W Fanning, +4 authors, Terry W Moore.
Angew Chem Int Ed Engl, 2016 Mar 02; 55(13). PMID: 26928945    Free PMC article.
The current use and attitudes towards tumor genome sequencing in breast cancer.
I Gingras, A Sonnenblick, +7 authors, H A Azim.
Sci Rep, 2016 Mar 05; 6. PMID: 26931736    Free PMC article.
Estrogen receptor-alpha as a predictive biomarker in endometrioid endometrial cancer.
Floor J Backes, Christopher J Walker, +5 authors, Adrian A Suarez.
Gynecol Oncol, 2016 Mar 10; 141(2). PMID: 26957478    Free PMC article.
The Metabolism, Analysis, and Targeting of Steroid Hormones in Breast and Prostate Cancer.
Cameron P Capper, James M Rae, Richard J Auchus.
Horm Cancer, 2016 Mar 13; 7(3). PMID: 26969590    Free PMC article.
Review.
Emerging therapeutic targets in metastatic progression: A focus on breast cancer.
Zhuo Li, Yibin Kang.
Pharmacol Ther, 2016 Mar 24; 161. PMID: 27000769    Free PMC article.
Review.
Drugging the undruggables: exploring the ubiquitin system for drug development.
Xiaodong Huang, Vishva M Dixit.
Cell Res, 2016 Mar 24; 26(4). PMID: 27002218    Free PMC article.
Highly Cited. Review.
How drug resistance takes shape.
Rinath Jeselsohn, Myles Brown.
Elife, 2016 Mar 25; 5. PMID: 27010172    Free PMC article.
Treating cancer with selective CDK4/6 inhibitors.
Ben O'Leary, Richard S Finn, Nicholas C Turner.
Nat Rev Clin Oncol, 2016 Apr 01; 13(7). PMID: 27030077
Highly Cited. Review.
Causal Therapy of Breast Cancer Irrelevant of Age, Tumor Stage and ER-Status: Stimulation of Estrogen Signaling Coupled With Breast Conserving Surgery.
Zsuzsanna Suba.
Recent Pat Anticancer Drug Discov, 2016 Apr 19; 11(3). PMID: 27087654    Free PMC article.
Review.
Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients.
Takashi Takeshita, Yutaka Yamamoto, +5 authors, Hirotaka Iwase.
Oncotarget, 2016 Apr 23; 7(22). PMID: 27102299    Free PMC article.
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer.
Ingrid A Mayer, Vandana G Abramson, +11 authors, Carlos L Arteaga.
Clin Cancer Res, 2016 Apr 30; 23(1). PMID: 27126994    Free PMC article.
Highly Cited.
Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.
Tesa M Severson, Ekaterina Nevedomskaya, +14 authors, Wilbert Zwart.
Oncotarget, 2016 Apr 30; 7(23). PMID: 27129152    Free PMC article.
Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development.
Bálint Mészáros, András Zeke, +2 authors, Zsuzsanna Dosztányi.
Biol Direct, 2016 May 07; 11. PMID: 27150584    Free PMC article.
Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial.
Ian E Krop, Ingrid A Mayer, +21 authors, Peter Schmid.
Lancet Oncol, 2016 May 09; 17(6). PMID: 27155741    Free PMC article.
Highly Cited.
Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth.
Frederik Holst, Erling A Hoivik, +11 authors, Andrew D Cherniack.
Sci Rep, 2016 May 11; 6. PMID: 27160768    Free PMC article.
Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant.
Jill M Spoerke, Steven Gendreau, +13 authors, Mark R Lackner.
Nat Commun, 2016 May 14; 7. PMID: 27174596    Free PMC article.
Highly Cited.
Heterogeneous estrogen receptor expression in circulating tumor cells suggests diverse mechanisms of fulvestrant resistance.
Costanza Paoletti, Jose M Larios, +13 authors, Daniel F Hayes.
Mol Oncol, 2016 May 15; 10(7). PMID: 27178224    Free PMC article.
ESR1 mutations affect anti-proliferative responses to tamoxifen through enhanced cross-talk with IGF signaling.
Luca Gelsomino, Guowei Gu, +8 authors, Suzanne A W Fuqua.
Breast Cancer Res Treat, 2016 May 15; 157(2). PMID: 27178332    Free PMC article.
Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance.
Luis Manso, Silvana Mourón, +8 authors, Miguel Quintela-Fandino.
PLoS One, 2016 May 20; 11(5). PMID: 27195705    Free PMC article.
Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity.
Daniel L Hertz, Allison Deal, +19 authors, William J Irvin.
Oncologist, 2016 May 27; 21(7). PMID: 27226358    Free PMC article.
Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity.
Su-Yang Liu, Nancy M Joseph, +12 authors, Gregor Krings.
Mod Pathol, 2016 Jun 04; 29(9). PMID: 27255162
Mathematical models of breast and ovarian cancers.
Dana-Adriana Botesteanu, Stanley Lipkowitz, Jung-Min Lee, Doron Levy.
Wiley Interdiscip Rev Syst Biol Med, 2016 Jun 04; 8(4). PMID: 27259061    Free PMC article.
Review.
Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts.
Jacqueline A Shaw, David S Guttery, +11 authors, R Charles Coombes.
Clin Cancer Res, 2016 Nov 05; 23(1). PMID: 27334837    Free PMC article.
Highly Cited.
The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.
William J Gibson, Erling A Hoivik, +25 authors, Helga B Salvesen.
Nat Genet, 2016 Jun 28; 48(8). PMID: 27348297    Free PMC article.
Highly Cited.
Anticipatory UPR Activation: A Protective Pathway and Target in Cancer.
David J Shapiro, Mara Livezey, +2 authors, Neal Andruska.
Trends Endocrinol Metab, 2016 Jun 30; 27(10). PMID: 27354311    Free PMC article.
Review.
Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications.
Jamunarani Veeraraghavan, Jiacheng Ma, Yiheng Hu, Xiao-Song Wang.
Breast Cancer Res Treat, 2016 Jul 04; 158(2). PMID: 27372070    Free PMC article.
Review.
COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR.
Renquan Lu, Xiaobo Hu, +9 authors, Lin Guo.
Nat Commun, 2016 Jul 05; 7. PMID: 27375289    Free PMC article.
Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.
Sara Kangaspeska, Susanne Hultsch, +6 authors, Olli Kallioniemi.
BMC Cancer, 2016 Jul 06; 16. PMID: 27378269    Free PMC article.
The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.
James D Joseph, Beatrice Darimont, +43 authors, Jeffrey H Hager.
Elife, 2016 Jul 14; 5. PMID: 27410477    Free PMC article.
GSK-3 inhibition overcomes chemoresistance in human breast cancer.
Andrey Ugolkov, Irina Gaisina, +9 authors, Andrew P Mazar.
Cancer Lett, 2016 Jul 18; 380(2). PMID: 27424289    Free PMC article.
A novel approach for next-generation sequencing of circulating tumor cells.
Stephanie S Yee, David B Lieberman, +13 authors, Erica L Carpenter.
Mol Genet Genomic Med, 2016 Jul 29; 4(4). PMID: 27468416    Free PMC article.
Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations.
Brendon Ladd, Anne Marie Mazzola, +17 authors, Celina M D'Cruz.
Oncotarget, 2016 Jul 30; 7(34). PMID: 27472462    Free PMC article.
Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer.
Heather A Parsons, Julia A Beaver, +27 authors, Ben H Park.
Clin Cancer Res, 2016 Aug 05; 23(2). PMID: 27489289    Free PMC article.
The Estrogen Receptor α-Cistrome Beyond Breast Cancer.
Marjolein Droog, Mark Mensink, Wilbert Zwart.
Mol Endocrinol, 2016 Aug 05; 30(10). PMID: 27489947    Free PMC article.
Review.
Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers.
Christopher A Miller, Yevgeniy Gindin, +17 authors, Matthew J Ellis.
Nat Commun, 2016 Aug 10; 7. PMID: 27502118    Free PMC article.
Data on affected cancer-related genes in pediatric t(12;21)-positive acute lymphoblastic leukemia patients harboring unbalanced der(6)t(X;6) translocations.
Eigil Kjeldsen.
Data Brief, 2016 Aug 11; 8. PMID: 27508240    Free PMC article.
Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer.
Tejal Joshi, Daniel Elias, +9 authors, Henrik J Ditzel.
Oncotarget, 2016 Aug 17; 7(35). PMID: 27528030    Free PMC article.
Prevalence of ESR1 Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer: A Secondary Analysis of the BOLERO-2 Clinical Trial.
Sarat Chandarlapaty, David Chen, +10 authors, Mary Ellen Moynahan.
JAMA Oncol, 2016 Aug 18; 2(10). PMID: 27532364    Free PMC article.
Highly Cited.
ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization.
Kinga Wrobel, Yiru Chen Zhao, +10 authors, Zeynep Madak-Erdogan.
Mol Endocrinol, 2016 Aug 18; 30(10). PMID: 27533791    Free PMC article.
ESR1 and PGR polymorphisms are associated with estrogen and progesterone receptor expression in breast tumors.
Daniel L Hertz, N Lynn Henry, +12 authors, James M Rae.
Physiol Genomics, 2016 Aug 21; 48(9). PMID: 27542969    Free PMC article.
The Role of Genomic Profiling in Advanced Breast Cancer: The Two Faces of Janus.
Yesim Eralp.
Transl Oncogenomics, 2016 Aug 23; 8(Suppl 1). PMID: 27547031    Free PMC article.
Review.
Tamoxifen Resistance: Emerging Molecular Targets.
Milena Rondón-Lagos, Victoria E Villegas, +2 authors, Peter G Zaphiropoulos.
Int J Mol Sci, 2016 Aug 23; 17(8). PMID: 27548161    Free PMC article.
Review.
Metastatic Breast Cancer With ESR1 Mutation: Clinical Management Considerations From the Molecular and Precision Medicine (MAP) Tumor Board at Massachusetts General Hospital.
Aditya Bardia, John A Iafrate, +2 authors, Valentina Nardi.
Oncologist, 2016 Aug 24; 21(9). PMID: 27551012    Free PMC article.
Minireview: The Link Between ERα Corepressors and Histone Deacetylases in Tamoxifen Resistance in Breast Cancer.
Stéphanie Légaré, Mark Basik.
Mol Endocrinol, 2016 Sep 02; 30(9). PMID: 27581354    Free PMC article.
Review.
Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney.
Rohit Mehra, Pankaj Vats, +22 authors, Arul M Chinnaiyan.
Cancer Discov, 2016 Nov 04; 6(11). PMID: 27604489    Free PMC article.
Current Status of Long Non-Coding RNAs in Human Breast Cancer.
Stefanie Cerk, Daniela Schwarzenbacher, +6 authors, Martin Pichler.
Int J Mol Sci, 2016 Sep 09; 17(9). PMID: 27608009    Free PMC article.
Review.
The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression.
Yashar S Niknafs, Sumin Han, +25 authors, Felix Y Feng.
Nat Commun, 2016 Sep 27; 7. PMID: 27666543    Free PMC article.
Highly Cited.
Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells.
Yumei Diao, Ani Azatyan, +4 authors, Peter G Zaphiropoulos.
Oncotarget, 2016 Oct 01; 7(44). PMID: 27689403    Free PMC article.
Patient-derived tumour xenografts for breast cancer drug discovery.
John W Cassidy, Ankita S Batra, Wendy Greenwood, Alejandra Bruna.
Endocr Relat Cancer, 2016 Oct 22; 23(12). PMID: 27702751    Free PMC article.
Review.
Detection and Characterization of Circulating Tumor Associated Cells in Metastatic Breast Cancer.
Zhaomei Mu, Naoual Benali-Furet, +9 authors, Massimo Cristofanilli.
Int J Mol Sci, 2016 Oct 06; 17(10). PMID: 27706044    Free PMC article.
Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI.
Chengjian Mao, Mara Livezey, Ji Eun Kim, David J Shapiro.
Sci Rep, 2016 Oct 08; 6. PMID: 27713477    Free PMC article.
Antiestrogens: structure-activity relationships and use in breast cancer treatment.
T Traboulsi, M El Ezzy, J L Gleason, S Mader.
J Mol Endocrinol, 2016 Oct 13; 58(1). PMID: 27729460    Free PMC article.
Review.
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.
A Harrod, J Fulton, +16 authors, S Ali.
Oncogene, 2016 Oct 18; 36(16). PMID: 27748765    Free PMC article.
Highly Cited.
Are Estrogen Receptor Genomic Aberrations Predictive of Hormone Therapy Response in Breast Cancer?
Sanaz Tabarestani, Marzieh Motallebi, Mohammad Esmaeil Akbari.
Iran J Cancer Prev, 2016 Oct 21; 9(4). PMID: 27761212    Free PMC article.
Review.
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.
Xiaoyong Fu, Rinath Jeselsohn, +24 authors, Rachel Schiff.
Proc Natl Acad Sci U S A, 2016 Oct 30; 113(43). PMID: 27791031    Free PMC article.
Kinetics, prognostic and predictive values of ESR1 circulating mutations in metastatic breast cancer patients progressing on aromatase inhibitor.
Florian Clatot, Anne Perdrix, +21 authors, Frédéric Di Fiore.
Oncotarget, 2016 Nov 02; 7(46). PMID: 27801670    Free PMC article.
Recent developments and translational aspects in targeted therapy for metastatic breast cancer.
Maximilian Marhold, Rupert Bartsch, Christoph Zielinski.
ESMO Open, 2016 Nov 16; 1(3). PMID: 27843605    Free PMC article.
Review.
The Role of Next-Generation Sequencing in Enabling Personalized Oncology Therapy.
C A Cummings, E Peters, +2 authors, M R Lackner.
Clin Transl Sci, 2016 Nov 20; 9(6). PMID: 27860319    Free PMC article.
Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer.
J F Hiken, J I McDonald, +8 authors, J R Edwards.
Oncogene, 2016 Nov 22; 36(16). PMID: 27869171    Free PMC article.
Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Sathish Srinivasan, Jerome C Nwachukwu, +15 authors, Kendall W Nettles.
Nat Chem Biol, 2016 Nov 22; 13(1). PMID: 27870835    Free PMC article.
Deciphering the divergent roles of progestogens in breast cancer.
Jason S Carroll, Theresa E Hickey, +2 authors, Wayne D Tilley.
Nat Rev Cancer, 2016 Nov 26; 17(1). PMID: 27885264
Review.
Tumor suppressor ING4 inhibits estrogen receptor activity in breast cancer cells.
Madeline M Keenen, Suwon Kim.
Breast Cancer (Dove Med Press), 2016 Nov 30; 8. PMID: 27895513    Free PMC article.
Intrinsic HER2 V777L mutation mediates resistance to trastuzumab in a breast cancer patient.
Yosuke Hirotsu, Hiroshi Nakagomi, +4 authors, Masao Omata.
Med Oncol, 2016 Dec 03; 34(1). PMID: 27900589
New Strategies in Metastatic Hormone Receptor-Positive Breast Cancer: Searching for Biomarkers to Tailor Endocrine and Other Targeted Therapies.
Rachel C Jankowitz, Steffi Oesterreich, Adrian V Lee, Nancy E Davidson.
Clin Cancer Res, 2016 Dec 17; 23(5). PMID: 27979914    Free PMC article.
Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists.
Weiyi Toy, Hazel Weir, +17 authors, Sarat Chandarlapaty.
Cancer Discov, 2016 Dec 18; 7(3). PMID: 27986707    Free PMC article.
Highly Cited.
Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.
Celine Lefebvre, Thomas Bachelot, +31 authors, Fabrice André.
PLoS Med, 2016 Dec 28; 13(12). PMID: 28027327    Free PMC article.
Highly Cited.
Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.
Luca Magnani, Gianmaria Frige, +16 authors, Saverio Minucci.
Nat Genet, 2017 Jan 24; 49(3). PMID: 28112739    Free PMC article.
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.
Dominik Glodzik, Sandro Morganella, +27 authors, Serena Nik-Zainal.
Nat Genet, 2017 Jan 24; 49(3). PMID: 28112740    Free PMC article.
Highly Cited.
Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer.
Rui Xiong, Jiong Zhao, +7 authors, Gregory R J Thatcher.
J Med Chem, 2017 Jan 25; 60(4). PMID: 28117994    Free PMC article.
A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.
Kelly Schoch, Linyan Meng, +39 authors, Vandana Shashi.
Am J Hum Genet, 2017 Jan 31; 100(2). PMID: 28132692    Free PMC article.
Method for generating multiple risky barcodes of complex diseases using ant colony algorithm.
Xiong Li, Wen Jiang.
Theor Biol Med Model, 2017 Feb 02; 14(1). PMID: 28143579    Free PMC article.
Detection fidelity of AR mutations in plasma derived cell-free DNA.
Alexa Goldstein, Patricia Valda Toro, +20 authors, Paula J Hurley.
Oncotarget, 2017 Feb 06; 8(9). PMID: 28152506    Free PMC article.
Racial disparity in survival from estrogen and progesterone receptor-positive breast cancer: implications for reducing breast cancer mortality disparities.
Garth H Rauscher, Abigail Silva, +3 authors, Kent Hoskins.
Breast Cancer Res Treat, 2017 Mar 03; 163(2). PMID: 28251385    Free PMC article.
Mutational studies on single circulating tumor cells isolated from the blood of inflammatory breast cancer patients.
Catherine Bingham, Sandra V Fernandez, +4 authors, R Katherine Alpaugh.
Breast Cancer Res Treat, 2017 Mar 09; 163(2). PMID: 28271309    Free PMC article.
Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.
Koen M A Dreijerink, Anna C Groner, +11 authors, Myles Brown.
Cell Rep, 2017 Mar 09; 18(10). PMID: 28273452    Free PMC article.
Germline genetic predictors of aromatase inhibitor concentrations, estrogen suppression and drug efficacy and toxicity in breast cancer patients.
Daniel L Hertz, N Lynn Henry, James M Rae.
Pharmacogenomics, 2017 Mar 28; 18(5). PMID: 28346074    Free PMC article.
Review.
Clinical Implications of ESR1 Mutations in Hormone Receptor-Positive Advanced Breast Cancer.
Tomas Reinert, Everardo D Saad, Carlos H Barrios, José Bines.
Front Oncol, 2017 Apr 01; 7. PMID: 28361033    Free PMC article.
Review.
Role of steroid receptor and coregulator mutations in hormone-dependent cancers.
Anna C Groner, Myles Brown.
J Clin Invest, 2017 Apr 04; 127(4). PMID: 28368289    Free PMC article.
Review.
The Evolving Role of the Estrogen Receptor Mutations in Endocrine Therapy-Resistant Breast Cancer.
Rinath Jeselsohn, Carmine De Angelis, Myles Brown, Rachel Schiff.
Curr Oncol Rep, 2017 Apr 05; 19(5). PMID: 28374222
Review.
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations.
David Brown, Dominiek Smeets, +18 authors, Christine Desmedt.
Nat Commun, 2017 Apr 22; 8. PMID: 28429735    Free PMC article.
Highly Cited.
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.
Feng Xie, Ke Jin, +13 authors, Long Zhang.
Nat Commun, 2017 Apr 27; 8. PMID: 28443643    Free PMC article.
Liquid biopsy: unlocking the potentials of cell-free DNA.
David Chu, Ben Ho Park.
Virchows Arch, 2017 May 04; 471(2). PMID: 28466157
Review.
Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers.
Jen-Hwey Chiu, Che-Sheng Wen, +5 authors, Yi-Ming Shyr.
J Transl Med, 2017 May 06; 15(1). PMID: 28472954    Free PMC article.
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
Ahmet Zehir, Ryma Benayed, +97 authors, Michael F Berger.
Nat Med, 2017 May 10; 23(6). PMID: 28481359    Free PMC article.
Highly Cited.
Advances in systemic therapy for metastatic breast cancer: future perspectives.
S P Corona, N Sobhani, +5 authors, D Generali.
Med Oncol, 2017 May 21; 34(7). PMID: 28526922
Review.
Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer.
Shiyi Yu, Xiuxiu Cai, +13 authors, Liming Chen.
Int J Biol Sci, 2017 May 23; 13(4). PMID: 28529458    Free PMC article.
Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models.
Amir Bahreini, Zheqi Li, +11 authors, Steffi Oesterreich.
Breast Cancer Res, 2017 May 26; 19(1). PMID: 28535794    Free PMC article.
Highly Cited.
Precision medicine in breast cancer: reality or utopia?
Ali Bettaieb, Catherine Paul, +3 authors, François Ghiringhelli.
J Transl Med, 2017 Jun 19; 15(1). PMID: 28623955    Free PMC article.
Review.
Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.
Jian Min, Valeria Sanabria Guillen, +10 authors, John A Katzenellenbogen.
J Med Chem, 2017 Jun 29; 60(14). PMID: 28657320    Free PMC article.
A Review of Fulvestrant in Breast Cancer.
Mark R Nathan, Peter Schmid.
Oncol Ther, 2017 Jul 07; 5(1). PMID: 28680952    Free PMC article.
Review.
Molecular genetics complexity impeding research progress in breast and ovarian cancers.
Ishita Gupta, Ikram Burney, Mansour S Al-Moundhri, Yahya Tamimi.
Mol Clin Oncol, 2017 Jul 08; 7(1). PMID: 28685067    Free PMC article.
Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor α.
Masayoshi Iizuka, Takao Susa, +2 authors, Tomoki Okazaki.
Proc Jpn Acad Ser B Phys Biol Sci, 2017 Aug 05; 93(7). PMID: 28769019    Free PMC article.
Comparison of ESR1 Mutations in Tumor Tissue and Matched Plasma Samples from Metastatic Breast Cancer Patients.
Takashi Takeshita, Yutaka Yamamoto, +5 authors, Hirotaka Iwase.
Transl Oncol, 2017 Aug 05; 10(5). PMID: 28778025    Free PMC article.
Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers.
Ganesh V Raj, Gangadhara Reddy Sareddy, +15 authors, Ratna K Vadlamudi.
Elife, 2017 Aug 09; 6. PMID: 28786813    Free PMC article.
Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.
Jennifer M Giltnane, Katherine E Hutchinson, +32 authors, Carlos L Arteaga.
Sci Transl Med, 2017 Aug 11; 9(402). PMID: 28794284    Free PMC article.
Estrogen receptor (ESR1) mutation in bone metastases from breast cancer.
Stephan Bartels, Matthias Christgen, +4 authors, Hans Kreipe.
Mod Pathol, 2017 Aug 12; 31(1). PMID: 28799536
Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer.
Svasti Haricharan, Nindo Punturi, +16 authors, Matthew J Ellis.
Cancer Discov, 2017 Aug 13; 7(10). PMID: 28801307    Free PMC article.
Genomic Evolution of Breast Cancer Metastasis and Relapse.
Lucy R Yates, Stian Knappskog, +27 authors, Peter J Campbell.
Cancer Cell, 2017 Aug 16; 32(2). PMID: 28810143    Free PMC article.
Highly Cited.
Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families.
Jun Li, Hongyan Li, +12 authors, Georgia Chenevix-Trench.
Breast Cancer Res Treat, 2017 Aug 26; 166(3). PMID: 28840378    Free PMC article.
Physician Experiences and Understanding of Genomic Sequencing in Oncology.
Caroline M Weipert, Kerry A Ryan, +6 authors, Victoria M Raymond.
J Genet Couns, 2017 Aug 26; 27(1). PMID: 28840409    Free PMC article.
First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.
Matthew P Goetz, Vera J Suman, +23 authors, James N Ingle.
J Clin Oncol, 2017 Aug 31; 35(30). PMID: 28854070    Free PMC article.
Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors.
Bernard L Marini, Lydia L Benitez, +43 authors, Carl Koschmann.
Transl Res, 2017 Sep 02; 188. PMID: 28860053    Free PMC article.
Clinical application of a cancer genomic profiling assay to guide precision medicine decisions.
Cheryl Eifert, Angeliki Pantazi, +9 authors, Alexei Protopopov.
Per Med, 2017 Sep 12; 14(4). PMID: 28890729    Free PMC article.
Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer.
Neel Shah, Ping Wang, +11 authors, Charles L Sawyers.
Elife, 2017 Sep 12; 6. PMID: 28891793    Free PMC article.
Highly Cited.
Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors.
Yuechao Zhao, Mary J Laws, +12 authors, Benita S Katzenellenbogen.
Cancer Res, 2017 Sep 15; 77(20). PMID: 28904064    Free PMC article.
Magnetic resonance metabolic profiling of estrogen receptor-positive breast cancer: correlation with currently used molecular markers.
Ji Soo Choi, Dahye Yoon, +5 authors, Min Jung Kim.
Oncotarget, 2017 Oct 04; 8(38). PMID: 28969000    Free PMC article.
Detection of ESR1 mutations in circulating cell-free DNA from patients with metastatic breast cancer treated with palbociclib and letrozole.
Rekha Gyanchandani, Karthik J Kota, +6 authors, Shannon L Puhalla.
Oncotarget, 2016 Aug 19; 8(40). PMID: 28978004    Free PMC article.
Estrogen receptor mutations and splice variants determined in liquid biopsies from metastatic breast cancer patients.
Nick Beije, Anieta M Sieuwerts, +14 authors, Stefan Sleijfer.
Mol Oncol, 2017 Oct 25; 12(1). PMID: 29063679    Free PMC article.
Combating subclonal evolution of resistant cancer phenotypes.
Samuel W Brady, Jasmine A McQuerry, +25 authors, Andrea H Bild.
Nat Commun, 2017 Nov 03; 8(1). PMID: 29093439    Free PMC article.
Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer.
Viroj Boonyaratanakornkit, Nalo Hamilton, +3 authors, Richard J Pietras.
Mol Cell Endocrinol, 2017 Nov 18; 466. PMID: 29146555    Free PMC article.
Review.
A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.
Philipp Y Maximov, Balkees Abderrahman, +3 authors, V Craig Jordan.
Endocr Relat Cancer, 2017 Nov 23; 25(2). PMID: 29162647    Free PMC article.
Review.
Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients.
Takashi Takeshita, Yutaka Yamamoto, +5 authors, Hirotaka Iwase.
BMC Cancer, 2017 Nov 24; 17(1). PMID: 29166868    Free PMC article.
ndmaSNF: cancer subtype discovery based on integrative framework assisted by network diffusion model.
Chao Yang, Shu-Guang Ge, Chun-Hou Zheng.
Oncotarget, 2017 Nov 29; 8(51). PMID: 29179495    Free PMC article.
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.
Lesley-Ann Martin, Ricardo Ribas, +25 authors, Mitch Dowsett.
Nat Commun, 2017 Dec 02; 8(1). PMID: 29192207    Free PMC article.
Breast cancer: The translation of big genomic data to cancer precision medicine.
Siew-Kee Low, Hitoshi Zembutsu, Yusuke Nakamura.
Cancer Sci, 2017 Dec 08; 109(3). PMID: 29215763    Free PMC article.
Review.
Comprehensive Mutation and Copy Number Profiling in Archived Circulating Breast Cancer Tumor Cells Documents Heterogeneous Resistance Mechanisms.
Costanza Paoletti, Andi K Cani, +24 authors, Scott A Tomlins.
Cancer Res, 2017 Dec 14; 78(4). PMID: 29233927    Free PMC article.
Are We Ready to Use ESR1 Mutations in Clinical Practice?
Rinath Jeselsohn.
Breast Care (Basel), 2017 Dec 14; 12(5). PMID: 29234250    Free PMC article.
Review.
Development of the CNS TAP tool for the selection of precision medicine therapies in neuro-oncology.
Joseph R Linzey, Bernard L Marini, +11 authors, Carl Koschmann.
J Neurooncol, 2017 Dec 14; 137(1). PMID: 29235051    Free PMC article.
Metabolism, pharmacokinetics, and bioavailability of ZB716, a Steroidal Selective Estrogen Receptor Downregulator (SERD).
Changde Zhang, Shanchun Guo, +5 authors, Guangdi Wang.
Oncotarget, 2017 Dec 22; 8(61). PMID: 29262607    Free PMC article.
Mutational profiles of breast cancer metastases from a rapid autopsy series reveal multiple evolutionary trajectories.
Bracha Erlanger Avigdor, Ashley Cimino-Mathews, +7 authors, Sarah J Wheelan.
JCI Insight, 2017 Dec 22; 2(24). PMID: 29263308    Free PMC article.
Nuclear receptors in cancer - uncovering new and evolving roles through genomic analysis.
Vineet K Dhiman, Michael J Bolt, Kevin P White.
Nat Rev Genet, 2017 Dec 28; 19(3). PMID: 29279606
Review.
Biomarkers of Everolimus Sensitivity in Hormone Receptor-Positive Breast Cancer.
Zongbi Yi, Fei Ma.
J Breast Cancer, 2017 Dec 30; 20(4). PMID: 29285035    Free PMC article.
Review.
Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.
Shanhang Jia, Mark T Miedel, +13 authors, Andrew M Stern.
Oncology, 2018 Jan 08; 94(3). PMID: 29306943    Free PMC article.
Using gene expression data to direct breast cancer therapy: evidence from a preclinical trial.
Shams Reaz, Deimante Tamkus, Eran R Andrechek.
J Mol Med (Berl), 2018 Jan 10; 96(2). PMID: 29313063    Free PMC article.
Review.
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers.
Matic Pavlin, Angelo Spinello, +5 authors, Alessandra Magistrato.
Sci Rep, 2018 Jan 14; 8(1). PMID: 29330437    Free PMC article.
Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer.
Jun Yang, Adrian L Harris, Andrew M Davidoff.
Int J Mol Sci, 2018 Jan 19; 19(1). PMID: 29342868    Free PMC article.
Review.
Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing.
Haitao Yang, MariaLynn Jaeger, +3 authors, Tao Weitao.
J Cancer, 2018 Jan 19; 9(2). PMID: 29344267    Free PMC article.
Review.
Estrogen Receptor-Positive Breast Cancer: Exploiting Signaling Pathways Implicated in Endocrine Resistance.
Adam M Brufsky, Maura N Dickler.
Oncologist, 2018 Jan 21; 23(5). PMID: 29352052    Free PMC article.
Review.
Toxicodynamics of Mycotoxins in the Framework of Food Risk Assessment-An In Silico Perspective.
Luca Dellafiora, Chiara Dall'Asta, Gianni Galaverna.
Toxins (Basel), 2018 Jan 24; 10(2). PMID: 29360783    Free PMC article.
Review.
Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer.
R J Hartmaier, S E Trabucco, +36 authors, A V Lee.
Ann Oncol, 2018 Jan 24; 29(4). PMID: 29360925    Free PMC article.
Highly Cited.
Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs).
Una Kjällquist, Rikard Erlandsson, +8 authors, Jonas Bergh.
BMC Cancer, 2018 Feb 13; 18(1). PMID: 29433456    Free PMC article.
Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.
Rinath Jeselsohn, Johann S Bergholz, +23 authors, Myles Brown.
Cancer Cell, 2018 Feb 14; 33(2). PMID: 29438694    Free PMC article.
Highly Cited.
AR Expression in Breast Cancer CTCs Associates with Bone Metastases.
Nicola Aceto, Aditya Bardia, +18 authors, Shyamala Maheswaran.
Mol Cancer Res, 2018 Feb 18; 16(4). PMID: 29453314    Free PMC article.
Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges.
Ramesh Butti, Sumit Das, +3 authors, Gopal C Kundu.
Mol Cancer, 2018 Feb 20; 17(1). PMID: 29455658    Free PMC article.
Review.
Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers.
Kriti Singh, Ravi S N Munuganti, +6 authors, Paul S Rennie.
Int J Mol Sci, 2018 Feb 22; 19(2). PMID: 29462880    Free PMC article.
ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models.
Shanchun Guo, Changde Zhang, +14 authors, Guangdi Wang.
Oncotarget, 2018 Feb 23; 9(6). PMID: 29467940    Free PMC article.
ESR1 and endocrine therapy resistance: more than just mutations.
S Piscuoglio, C K Y Ng, +2 authors, J S Reis-Filho.
Ann Oncol, 2018 Mar 10; 29(4). PMID: 29522117    Free PMC article.
Identification of novel MECOM gene fusion and personalized therapeutic targets through integrative clinical sequencing in secondary acute myeloid leukemia in a patient with severe congenital neutropenia: a case report and literature review.
James A Connelly, Rajen J Mody, +6 authors, Kelly Walkovich.
Cold Spring Harb Mol Case Stud, 2018 Mar 25; 4(2). PMID: 29572239    Free PMC article.
Review.
Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.
John A Katzenellenbogen, Christopher G Mayne, +2 authors, Sarat Chandarlapaty.
Nat Rev Cancer, 2018 Apr 18; 18(6). PMID: 29662238    Free PMC article.
Highly Cited. Review.
Implications of ESR1 Mutations in Hormone Receptor-Positive Breast Cancer.
Tomás Reinert, Rodrigo Gonçalves, José Bines.
Curr Treat Options Oncol, 2018 Apr 19; 19(5). PMID: 29666928
Review.
Practical consensus recommendations regarding the use of hormonal therapy in metastatic breast cancer.
Senthil Rajappa, J Bajpai, +8 authors, S Aggarwal.
South Asian J Cancer, 2018 May 04; 7(2). PMID: 29721481    Free PMC article.
Low neutrophil-lymphocyte ratio correlates with extended survival in patients with metastatic breast cancer who achieved clinically complete response following multidisciplinary therapy: A retrospective study.
Haruko Takuwa, Wakako Tsuji, +2 authors, Fumiaki Yotsumoto.
Oncol Lett, 2018 May 05; 15(5). PMID: 29725410    Free PMC article.
The Impact of ESR1 Mutations on the Treatment of Metastatic Breast Cancer.
Sasha M Pejerrey, Derek Dustin, +3 authors, Suzanne A W Fuqua.
Horm Cancer, 2018 May 08; 9(4). PMID: 29736566
Review.
REGGAE: a novel approach for the identification of key transcriptional regulators.
Tim Kehl, Lara Schneider, +14 authors, Hans-Peter Lenhof.
Bioinformatics, 2018 May 10; 34(20). PMID: 29741575    Free PMC article.
Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets.
Leah A Gates, Guowei Gu, +22 authors, Charles E Foulds.
Oncogene, 2018 May 12; 37(33). PMID: 29748621    Free PMC article.
A Convergence-Based Framework for Cancer Drug Resistance.
David J Konieczkowski, Cory M Johannessen, Levi A Garraway.
Cancer Cell, 2018 May 16; 33(5). PMID: 29763622    Free PMC article.
Highly Cited. Review.
Precision Medicine in Hormone Receptor-Positive Breast Cancer.
Azadeh Nasrazadani, Roby A Thomas, Steffi Oesterreich, Adrian V Lee.
Front Oncol, 2018 May 22; 8. PMID: 29780747    Free PMC article.
Review.
Identifying Circulating Tumor DNA Mutation Profiles in Metastatic Breast Cancer Patients with Multiline Resistance.
Zhe-Yu Hu, Ning Xie, +18 authors, Quchang Ouyang.
EBioMedicine, 2018 May 29; 32. PMID: 29807833    Free PMC article.
Dramatic response to cyclin D-dependent kinase 4/6 inhibitor in refractory poorly differentiated neuroendocrine carcinoma of the breast.
Allison Shanks, Julia Choi, Vinit Karur.
Proc (Bayl Univ Med Cent), 2018 Jun 16; 31(3). PMID: 29904310    Free PMC article.
Overcoming endocrine resistance in hormone receptor-positive breast cancer.
A AlFakeeh, C Brezden-Masley.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910644    Free PMC article.
Review.
A New Role for Estrogen Receptor α in Cell Proliferation and Cancer: Activating the Anticipatory Unfolded Protein Response.
Mara Livezey, Ji Eun Kim, David J Shapiro.
Front Endocrinol (Lausanne), 2018 Jul 03; 9. PMID: 29963013    Free PMC article.
Review.
FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome.
Willemijne Schrijver, Karianne Schuurman, +10 authors, Wilbert Zwart.
Mol Oncol, 2018 Jul 05; 12(11). PMID: 29972720    Free PMC article.
Genetic diversity of NDUFV1-dependent mitochondrial complex I deficiency.
Anshika Srivastava, Kinshuk Raj Srivastava, +8 authors, Stephanie L Bielas.
Eur J Hum Genet, 2018 Jul 07; 26(11). PMID: 29976978    Free PMC article.
Overcoming Therapeutic Resistance of Triple Positive Breast Cancer with CDK4/6 Inhibition.
Troy B Schedin, Virginia F Borges, Elena Shagisultanova.
Int J Breast Cancer, 2018 Jul 19; 2018. PMID: 30018827    Free PMC article.
Review.
Multi-drug therapy in breast cancer: are there any alternatives?
Partha Mitra.
Ann Transl Med, 2018 Jul 20; 6(11). PMID: 30023384    Free PMC article.
Unraveling the clinicopathological features driving the emergence of ESR1 mutations in metastatic breast cancer.
Yanan Kuang, Bilal Siddiqui, +14 authors, Rinath Jeselsohn.
NPJ Breast Cancer, 2018 Aug 08; 4. PMID: 30083595    Free PMC article.
A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer.
Tanya T Kwan, Aditya Bardia, +15 authors, Shyamala Maheswaran.
Cancer Discov, 2018 Aug 15; 8(10). PMID: 30104333    Free PMC article.
Association of tamoxifen resistance and lipid reprogramming in breast cancer.
Susanne Hultsch, Matti Kankainen, +5 authors, Olli Kallioniemi.
BMC Cancer, 2018 Aug 26; 18(1). PMID: 30143015    Free PMC article.
Chemical modulation of transcription factors.
Bianca Wiedemann, Jörn Weisner, Daniel Rauh.
Medchemcomm, 2018 Aug 29; 9(8). PMID: 30151079    Free PMC article.
Review.
CDK4/6 inhibitors in the treatment of patients with breast cancer: summary of a multidisciplinary round-table discussion.
Matthias Preusser, Leticia De Mattos-Arruda, +5 authors, Christoph C Zielinski.
ESMO Open, 2018 Sep 01; 3(5). PMID: 30167331    Free PMC article.
Review.
Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer.
Rasmus Siersbæk, Sanjeev Kumar, Jason S Carroll.
Genes Dev, 2018 Sep 06; 32(17-18). PMID: 30181360    Free PMC article.
Review.
ESR1 mutations: Pièce de résistance.
Berry Button, Ben Ho Park.
Genes Dis, 2016 Apr 19; 3(2). PMID: 30258881    Free PMC article.
Review.
The predictive ability of plasma ESR1 mutations for the efficacy of endocrine therapy in hormone-receptor-positive advanced breast cancer.
Yangfan Du, Na Li, +2 authors, Shunchao Yan.
Onco Targets Ther, 2018 Oct 03; 11. PMID: 30275706    Free PMC article.
Moving Breast Cancer Therapy up a Notch.
Erik W J Mollen, Jonathan Ient, +4 authors, Marc A G G Vooijs.
Front Oncol, 2018 Dec 06; 8. PMID: 30515368    Free PMC article.
Review.
Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway.
Zhiqiang Li, Pedram Razavi, +18 authors, Sarat Chandarlapaty.
Cancer Cell, 2018 Dec 12; 34(6). PMID: 30537512    Free PMC article.
Highly Cited.
Mortality after breast cancer as a function of time since diagnosis by estrogen receptor status and age at diagnosis.
Harindra Jayasekara, Robert J MacInnis, +11 authors, John L Hopper.
Int J Cancer, 2019 Feb 17; 145(12). PMID: 30771221    Free PMC article.
Cyclin E mRNA: Assessing Cyclin-Dependent Kinase (CDK) Activation State to Elucidate Breast Cancer Resistance to CDK4/6 Inhibitors.
Sarat Chandarlapaty, Pedram Razavi.
J Clin Oncol, 2019 Mar 29; 37(14). PMID: 30920879    Free PMC article.
ESR1 mutations in breast cancer.
Derek Dustin, Guowei Gu, Suzanne A W Fuqua.
Cancer, 2019 Jul 19; 125(21). PMID: 31318440    Free PMC article.
Review.
ERα-targeted endocrine therapy, resistance and the role of GPER.
Richard A Pepermans, Eric R Prossnitz.
Steroids, 2019 Sep 14; 152. PMID: 31518595    Free PMC article.
Review.
Distinct Roles for BET Family Members in Estrogen Receptor α Enhancer Function and Gene Regulation in Breast Cancer Cells.
Shino Murakami, Rui Li, +3 authors, W Lee Kraus.
Mol Cancer Res, 2019 Sep 26; 17(12). PMID: 31551256    Free PMC article.
Non-canonical Estrogen Signaling in Endocrine Resistance.
Prathibha Ranganathan, Namratha Nadig, Sughosha Nambiar.
Front Endocrinol (Lausanne), 2019 Nov 22; 10. PMID: 31749762    Free PMC article.
Review.
Androgen Receptor Is a Non-canonical Inhibitor of Wild-Type and Mutant Estrogen Receptors in Hormone Receptor-Positive Breast Cancers.
Suriyan Ponnusamy, Sarah Asemota, +20 authors, Ramesh Narayanan.
iScience, 2019 Nov 08; 21. PMID: 31698248    Free PMC article.
New insights into acquired endocrine resistance of breast cancer.
Ping Fan, V Craig Jordan.
Cancer Drug Resist, 2019 Dec 10; 2. PMID: 31815253    Free PMC article.
Clinical Implications of Monitoring ESR1 Mutations by Circulating Tumor DNA in Estrogen Receptor Positive Metastatic Breast Cancer: A Pilot Study.
Xuelu Li, Jiawei Lu, +3 authors, Man Li.
Transl Oncol, 2019 Dec 27; 13(2). PMID: 31877464    Free PMC article.
Estrogen receptor coregulator binding modulator (ERX-11) enhances the activity of CDK4/6 inhibitors against estrogen receptor-positive breast cancers.
Suryavathi Viswanadhapalli, Shihong Ma, +17 authors, Ratna K Vadlamudi.
Breast Cancer Res, 2019 Dec 28; 21(1). PMID: 31878959    Free PMC article.
Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study.
Laith N Al-Eitan, Doaa M Rababa'h, Mansour A Alghamdi, Rame H Khasawneh.
BMC Cancer, 2020 Jan 01; 19(1). PMID: 31888550    Free PMC article.
A right atrium metastasis of breast cancer after long-term endocrine therapy.
Fengrui Xu, Xiaodi Wang, Zefei Jiang.
Ann Transl Med, 2020 Jan 14; 7(22). PMID: 31930103    Free PMC article.
Principles of digital PCR and its applications in current obstetrical and gynecological diseases.
Xiaodong Mao, Chao Liu, +2 authors, Kangsheng Liu.
Am J Transl Res, 2020 Jan 15; 11(12). PMID: 31934273    Free PMC article.
Review.
Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy.
Suzanne E Wardell, Alexander P Yllanes, +7 authors, Donald P McDonnell.
Breast Cancer Res Treat, 2019 Sep 29; 179(1). PMID: 31562570    Free PMC article.
Prevalence of ESR1 Mutation in Chinese ER-Positive Breast Cancer.
Wenzhen Zhu, Chongyang Ren, +3 authors, Ning Liao.
Onco Targets Ther, 2020 Feb 06; 13. PMID: 32021303    Free PMC article.
ESR1 mutations are frequent in newly diagnosed metastatic and loco-regional recurrence of endocrine-treated breast cancer and carry worse prognosis.
Adi Zundelevich, Maya Dadiani, +14 authors, Einav Nili Gal-Yam.
Breast Cancer Res, 2020 Feb 06; 22(1). PMID: 32014063    Free PMC article.
Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines.
Abbas Khan, Ashfaq-Ur-Rehman, +7 authors, Dong-Qing Wei.
Front Mol Biosci, 2020 Feb 11; 6. PMID: 32039233    Free PMC article.
Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer.
Chih-Yang Wang, Chung-Chieh Chiao, +10 authors, Ming-Derg Lai.
Am J Cancer Res, 2020 Feb 18; 10(1). PMID: 32064155    Free PMC article.
Targeted deep sequencing revealed variants in cell-free DNA of hormone receptor-positive metastatic breast cancer patients.
Corinna Keup, Karim Benyaa, +7 authors, Sabine Kasimir-Bauer.
Cell Mol Life Sci, 2019 Jun 30; 77(3). PMID: 31254045    Free PMC article.
Mechanisms of resistance to estrogen receptor modulators in ER+/HER2- advanced breast cancer.
Jin Zhang, Qianying Wang, +3 authors, Zhengmao Zhu.
Cell Mol Life Sci, 2019 Sep 01; 77(4). PMID: 31471681
Review.
Molecular Barcode Sequencing of the Whole Ligand Binding Domain of the ESR1 Gene in Cell-Free DNA from Patients with Metastatic Breast Cancer.
Nanae Masunaga, Naofumi Kagara, +8 authors, Shinzaburo Noguchi.
Transl Oncol, 2020 Feb 28; 13(3). PMID: 32105989    Free PMC article.
Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma.
Yosuke Hirotsu, Sotaro Otake, +6 authors, Masao Omata.
Sci Rep, 2020 Feb 27; 10(1). PMID: 32099048    Free PMC article.
Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System.
Mark T Miedel, Dillon C Gavlock, +3 authors, Andrew M Stern.
Sci Rep, 2019 Jun 07; 9(1). PMID: 31171849    Free PMC article.
Immunohistochemical analysis of estrogen receptor in breast cancer with ESR1 mutations detected by hybrid capture-based next-generation sequencing.
Dara S Ross, Ahmet Zehir, +9 authors, Hannah Y Wen.
Mod Pathol, 2018 Aug 31; 32(1). PMID: 30158597    Free PMC article.
The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.
Pedram Razavi, Matthew T Chang, +42 authors, José Baselga.
Cancer Cell, 2018 Sep 12; 34(3). PMID: 30205045    Free PMC article.
Highly Cited.
Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer.
Ahmed Basudan, Nolan Priedigkeit, +16 authors, Steffi Oesterreich.
Mol Cancer Res, 2018 Oct 26; 17(2). PMID: 30355675    Free PMC article.
Zeitgebers and their association with rest-activity patterns.
Mirja Quante, Sara Mariani, +9 authors, Susan Redline.
Chronobiol Int, 2018 Oct 27; 36(2). PMID: 30365354    Free PMC article.
Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations.
Liqun Yu, Lawrence Wang, +7 authors, David J Shapiro.
Cancer Lett, 2018 Nov 13; 442. PMID: 30419347    Free PMC article.
Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer.
E S Sokol, Y X Feng, +12 authors, R J Hartmaier.
Ann Oncol, 2018 Nov 14; 30(1). PMID: 30423024    Free PMC article.
The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2.
Kyle T Helzer, Mary Szatkowski Ozers, +6 authors, Elaine T Alarid.
Mol Cell Biol, 2018 Nov 21; 39(3). PMID: 30455249    Free PMC article.
Molecular characterisation of aromatase inhibitor-resistant advanced breast cancer: the phenotypic effect of ESR1 mutations.
Elena Lopez-Knowles, Alex Pearson, +11 authors, Mitch Dowsett.
Br J Cancer, 2018 Dec 20; 120(2). PMID: 30563991    Free PMC article.
The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling: Implicating TIGAR in somatic resistance to endocrine therapy.
Marco Fiorillo, Rosa Sanchez-Alvarez, Federica Sotgia, Michael P Lisanti.
Aging (Albany NY), 2018 Dec 24; 10(12). PMID: 30573703    Free PMC article.
Recurrent activating mutations of PPARγ associated with luminal bladder tumors.
Natacha Rochel, Clémentine Krucker, +24 authors, Isabelle Bernard-Pierrot.
Nat Commun, 2019 Jan 18; 10(1). PMID: 30651555    Free PMC article.
Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways.
Yesim Gökmen-Polar, Yaseswini Neelamraju, +7 authors, Sunil S Badve.
EMBO Rep, 2019 Jan 23; 20(2). PMID: 30665944    Free PMC article.
Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions.
Adriana C Rodriguez, Zannel Blanchard, Kathryn A Maurer, Jason Gertz.
Horm Cancer, 2019 Feb 04; 10(2-3). PMID: 30712080    Free PMC article.
Highly Cited. Review.
Targeted mutation detection in breast cancer using MammaSeq™.
Nicholas G Smith, Rekha Gyanchandani, +12 authors, Adrian V Lee.
Breast Cancer Res, 2019 Feb 10; 21(1). PMID: 30736836    Free PMC article.
Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling.
Silvia-E Glont, Igor Chernukhin, Jason S Carroll.
Cell Rep, 2019 Mar 07; 26(10). PMID: 30840881    Free PMC article.
The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1.
Junmei Cairns, James N Ingle, +5 authors, Liewei Wang.
Breast Cancer Res, 2019 Apr 05; 21(1). PMID: 30944027    Free PMC article.
Fulvestrant in the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: A review.
Junjie Li, Zhonghua Wang, Zhimin Shao.
Cancer Med, 2019 Apr 21; 8(5). PMID: 31004402    Free PMC article.
Review.
Middle-way flexible docking: Pose prediction using mixed-resolution Monte Carlo in estrogen receptor α.
Justin Spiriti, Sundar Raman Subramanian, +2 authors, Daniel M Zuckerman.
PLoS One, 2019 Apr 24; 14(4). PMID: 31013302    Free PMC article.
Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics.
Natalia A Riobo-Del Galdo, Ángela Lara Montero, Eva V Wertheimer.
Cells, 2019 Apr 28; 8(4). PMID: 31027259    Free PMC article.
Review.
Steroid receptor/coactivator binding inhibitors: An update.
Kornelia J Skowron, Kenneth Booker, +7 authors, Terry W Moore.
Mol Cell Endocrinol, 2019 Jun 05; 493. PMID: 31163202    Free PMC article.
Review.
Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer.
Zannel Blanchard, Jeffery M Vahrenkamp, +2 authors, Jason Gertz.
Genome Res, 2019 Aug 01; 29(9). PMID: 31362937    Free PMC article.
Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy.
Sung Pil Hong, Thalia E Chan, +9 authors, Luca Magnani.
Nat Commun, 2019 Sep 04; 10(1). PMID: 31477698    Free PMC article.
The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies.
Berry Button, Sarah Croessmann, +18 authors, Ben Ho Park.
Breast Cancer Res Treat, 2018 Dec 19; 174(2). PMID: 30560461    Free PMC article.
The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer.
Leticia De Mattos-Arruda, Stephen-John Sammut, +31 authors, Carlos Caldas.
Cell Rep, 2019 May 30; 27(9). PMID: 31141692    Free PMC article.
Highly Cited.
PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies.
Yu Tang, Jing Li, +9 authors, Quchang Ouyang.
Aging (Albany NY), 2020 Jan 26; 12(2). PMID: 31980592    Free PMC article.
Collective effects of long-range DNA methylations predict gene expressions and estimate phenotypes in cancer.
Soyeon Kim, Hyun Jung Park, Xiangqin Cui, Degui Zhi.
Sci Rep, 2020 Mar 05; 10(1). PMID: 32127627    Free PMC article.
Vitamin D Receptor Signaling and Cancer.
Moray J Campbell, Donald L Trump.
Endocrinol Metab Clin North Am, 2017 Oct 31; 46(4). PMID: 29080633    Free PMC article.
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G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.
Kaitlyn J Andreano, Suzanne E Wardell, +15 authors, John D Norris.
Breast Cancer Res Treat, 2020 Mar 05; 180(3). PMID: 32130619    Free PMC article.
Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study.
Jamie R Kutasovic, Amy E McCart Reed, +16 authors, Peter T Simpson.
J Pathol Clin Res, 2018 Sep 25; 5(1). PMID: 30246500    Free PMC article.
A single droplet digital PCR for ESR1 activating mutations detection in plasma.
Emmanuelle Jeannot, Lauren Darrigues, +13 authors, Charlotte Proudhon.
Oncogene, 2020 Feb 12; 39(14). PMID: 32042112
Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer.
Amy M Fowler, Kelley Salem, +6 authors, Aparna M Mahajan.
Horm Cancer, 2020 Jan 17; 11(2). PMID: 31942683    Free PMC article.
Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health.
Feixiong Cheng, Han Liang, +2 authors, Ruth Nussinov.
Pharmacol Rev, 2018 Dec 14; 71(1). PMID: 30545954    Free PMC article.
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Quantitative Evaluation of the Transcriptional Activity of Steroid Hormone Receptor Mutants and Variants Using a Single Vector With Two Reporters and a Receptor Expression Cassette.
Huimin Ji, Ying Li, +12 authors, Fei Xiao.
Front Endocrinol (Lausanne), 2020 Apr 17; 11. PMID: 32296391    Free PMC article.
Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.
Ugo Testa, Germana Castelli, Elvira Pelosi.
Med Sci (Basel), 2020 Mar 27; 8(1). PMID: 32210163    Free PMC article.
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Overcoming Endocrine Resistance in Breast Cancer.
Ariella B Hanker, Dhivya R Sudhan, Carlos L Arteaga.
Cancer Cell, 2020 Apr 15; 37(4). PMID: 32289273    Free PMC article.
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Estrogen receptor mutations found in breast cancer metastases integrated with the molecular pharmacology of selective ER modulators.
V Craig Jordan, Ramona Curpan, Philipp Y Maximov.
J Natl Cancer Inst, 2015 Apr 04; 107(6). PMID: 25838462    Free PMC article.
Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma.
Lan Cao, Ahmed Basudan, +12 authors, Jennifer M Atkinson.
Cancer Lett, 2019 Jun 24; 461. PMID: 31229512    Free PMC article.
Mutational landscape and genetic signatures of cell-free DNA in tumour-induced osteomalacia.
Nan Wu, Zhen Zhang, +32 authors, Zhihong Wu.
J Cell Mol Med, 2020 Apr 12; 24(9). PMID: 32277576    Free PMC article.
The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors.
Jacob Rinaldi, Ethan S Sokol, +6 authors, Gerard Manning.
PLoS One, 2020 May 07; 15(5). PMID: 32374727    Free PMC article.
CellExpress: a comprehensive microarray-based cancer cell line and clinical sample gene expression analysis online system.
Yi-Fang Lee, Chien-Yueh Lee, +3 authors, Eric Y Chuang.
Database (Oxford), 2018 Apr 25; 2018. PMID: 29688349    Free PMC article.
The signature of pharmaceutical sensitivity based on ctDNA mutation in eleven cancers.
Shumei Zhang, Mu Su, +2 authors, Yan Zhang.
Exp Biol Med (Maywood), 2020 Feb 14; 245(8). PMID: 32050795    Free PMC article.
Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer.
Jamie R Kutasovic, Amy E McCart Reed, +2 authors, Peter T Simpson.
Cancers (Basel), 2020 Apr 05; 12(4). PMID: 32244556    Free PMC article.
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Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.
Abdulaziz B Hamid, Ruben C Petreaca.
Cancers (Basel), 2020 Apr 15; 12(4). PMID: 32283832    Free PMC article.
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Integration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy.
George Vasmatzis, Minetta C Liu, +12 authors, Panos Z Anastasiadis.
Mayo Clin Proc, 2019 Nov 07; 95(2). PMID: 31685261    Free PMC article.
Advances in endocrine and targeted therapy for hormone-receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer.
Le-Sang Shen, Xiao-Yan Jin, +2 authors, Jian Huang.
Chin Med J (Engl), 2020 Apr 09; 133(9). PMID: 32265426    Free PMC article.
Multimodal Targeted Deep Sequencing of Circulating Tumor Cells and Matched Cell-Free DNA Provides a More Comprehensive Tool to Identify Therapeutic Targets in Metastatic Breast Cancer Patients.
Corinna Keup, Markus Storbeck, +5 authors, Sabine Kasimir-Bauer.
Cancers (Basel), 2020 May 01; 12(5). PMID: 32349306    Free PMC article.
Advances in the Detection Technologies and Clinical Applications of Circulating Tumor DNA in Metastatic Breast Cancer.
Hao Liao, Huiping Li.
Cancer Manag Res, 2020 Jun 18; 12. PMID: 32547192    Free PMC article.
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Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
Jun Liang, Robert Blake, +30 authors, Xiaojing Wang.
ACS Med Chem Lett, 2020 Jun 20; 11(6). PMID: 32551022    Free PMC article.
The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor-Positive Breast Cancers.
Irida Kastrati, Stacey E P Joosten, +10 authors, Jonna Frasor.
Mol Cancer Res, 2020 Apr 05; 18(7). PMID: 32245803    Free PMC article.
The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor.
Kaitlyn J Andreano, Jennifer G Baker, +10 authors, Donald P McDonnell.
Mol Cancer Ther, 2020 May 10; 19(7). PMID: 32381587    Free PMC article.
The Network of Angiotensin Receptors in Breast Cancer.
Filippo Acconcia.
Cells, 2020 May 31; 9(6). PMID: 32471115    Free PMC article.
Review.
Phase II Study of AZD4547 in Patients With Tumors Harboring Aberrations in the FGFR Pathway: Results From the NCI-MATCH Trial (EAY131) Subprotocol W.
Young K Chae, Fangxin Hong, +19 authors, Keith T Flaherty.
J Clin Oncol, 2020 May 29; 38(21). PMID: 32463741    Free PMC article.
Computer-Aided Ligand Discovery for Estrogen Receptor Alpha.
Divya Bafna, Fuqiang Ban, +2 authors, Artem Cherkasov.
Int J Mol Sci, 2020 Jun 18; 21(12). PMID: 32545494    Free PMC article.
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Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.
Jocelyn Luveta, Ruth M Parks, +2 authors, Simon J Johnston.
Oncol Ther, 2020 Jul 24; 8(1). PMID: 32700069    Free PMC article.
Review.
Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation.
Simon J Johnston, Kwok-Leung Cheung.
Oncol Ther, 2018 Dec 01; 6(2). PMID: 32700026    Free PMC article.
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MAGPEL: an autoMated pipeline for inferring vAriant-driven Gene PanEls from the full-length biomedical literature.
Nafiseh Saberian, Adib Shafi, Azam Peyvandipour, Sorin Draghici.
Sci Rep, 2020 Jul 25; 10(1). PMID: 32703994    Free PMC article.
Increased frequency of ESR1 mutation in metastatic breast cancer by dosing selective estrogen receptor modulator followed by aromatase inhibitor.
Kaoru Takeshima, Tetsu Hayashida, +5 authors, Yuko Kitagawa.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724363    Free PMC article.
Enrichment of kinase fusions in ESR1 wild-type, metastatic breast cancer revealed by a systematic analysis of 4854 patients.
D S Ross, B Liu, +12 authors, J F Hechtman.
Ann Oncol, 2020 Apr 30; 31(8). PMID: 32348852    Free PMC article.
Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Aradhana Rani, Justin Stebbing, Georgios Giamas, John Murphy.
Front Endocrinol (Lausanne), 2019 Jun 11; 10. PMID: 31178825    Free PMC article.
Highly Cited. Review.
Clinically Integrated Sequencing Alters Therapy in Children and Young Adults With High-Risk Glial Brain Tumors.
Carl Koschmann, Yi-Mi Wu, +26 authors, Rajen Mody.
JCO Precis Oncol, 2018 Jan 01; 2. PMID: 32832832    Free PMC article.
DICER1 Mutations in the Era of Expanding Integrative Clinical Sequencing in Pediatric Oncology.
Kelly M Bailey, Michelle F Jacobs, +4 authors, Rajen J Mody.
JCO Precis Oncol, 2019 Jan 01; 3. PMID: 32832834    Free PMC article.
SETER/PR: a robust 18-gene predictor for sensitivity to endocrine therapy for metastatic breast cancer.
Bruno V Sinn, Chunxiao Fu, +23 authors, W Fraser Symmans.
NPJ Breast Cancer, 2019 Jun 25; 5. PMID: 31231679    Free PMC article.
Exosomal MicroRNAs in Pregnancy Provides Insight into a Possible Cure for Cancer.
Preenan Pillay, Kogi Moodley, Manu Vatish, Jagidesa Moodley.
Int J Mol Sci, 2020 Aug 06; 21(15). PMID: 32751127    Free PMC article.
Homology models of mouse and rat estrogen receptor-α ligand-binding domain created by in silico mutagenesis of a human template: molecular docking with 17ß-estradiol, diethylstilbestrol, and paraben analogs.
Thomas L Gonzalez, James M Rae, Justin A Colacino, Rudy J Richardson.
Comput Toxicol, 2019 Feb 12; 10. PMID: 30740556    Free PMC article.
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes.
Xinzhe Yu, Ping Yi, +7 authors, Bert W O'Malley.
Mol Cell, 2020 Jul 16; 79(5). PMID: 32668201    Free PMC article.
De Novo ESR1 Hotspot Mutation in a Patient With Endometrial Cancer Treated With an Aromatase Inhibitor.
Adeline Morel, Julien Masliah-Planchon, +7 authors, Maud Kamal.
JCO Precis Oncol, 2019 May 21; 3. PMID: 32914015    Free PMC article.
Opportunities and Challenges for Analyzing Cancer Data at the Inter- and Intra-Institutional Levels.
Julie Wu, Jordan Bryan, +9 authors, Jeremy L Warner.
JCO Precis Oncol, 2020 Sep 15; 4. PMID: 32923903    Free PMC article.
Transcription regulation of MYB: a potential and novel therapeutic target in cancer.
Partha Mitra.
Ann Transl Med, 2019 Jan 01; 6(22). PMID: 30596073    Free PMC article.
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A Guide to PIN1 Function and Mutations Across Cancers.
Maguie El Boustani, Lucia De Stefano, +6 authors, Flavio Rizzolio.
Front Pharmacol, 2019 Feb 07; 9. PMID: 30723410    Free PMC article.
Targeted Next-Generation Sequencing Reveals Clinically Actionable BRAF and ESR1 Mutations in Low-Grade Serous Ovarian Carcinoma.
Elizabeth H Stover, Colleen Feltmate, +3 authors, Panagiotis A Konstantinopoulos.
JCO Precis Oncol, 2018 Jan 01; 2018. PMID: 30828692    Free PMC article.
Chemotherapy Modulates Endocrine Therapy-Related Resistance Mutations in Metastatic Breast Cancer.
Dabo Zhou, Quchang Ouyang, +6 authors, Zhe-Yu Hu.
Transl Oncol, 2019 Mar 21; 12(5). PMID: 30893632    Free PMC article.
Identification of Triple-Negative Breast Cancer Genes and a Novel High-Risk Breast Cancer Prediction Model Development Based on PPI Data and Support Vector Machines.
Ming Li, Yu Guo, Yuan-Ming Feng, Ning Zhang.
Front Genet, 2019 Apr 02; 10. PMID: 30930932    Free PMC article.
Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance.
Eylem Kulkoyluoglu-Cotul, Brandi Patrice Smith, +12 authors, Zeynep Madak-Erdogan.
Cancers (Basel), 2019 Apr 17; 11(4). PMID: 30987380    Free PMC article.
ESR1 alterations and metastasis in estrogen receptor positive breast cancer.
Jonathan T Lei, Xuxu Gou, Sinem Seker, Matthew J Ellis.
J Cancer Metastasis Treat, 2019 May 21; 5. PMID: 31106278    Free PMC article.
The Central Contributions of Breast Cancer Stem Cells in Developing Resistance to Endocrine Therapy in Estrogen Receptor (ER)-Positive Breast Cancer.
David Rodriguez, Marc Ramkairsingh, +3 authors, Damu Tang.
Cancers (Basel), 2019 Jul 25; 11(7). PMID: 31336602    Free PMC article.
Review.
Blood-based monitoring identifies acquired and targetable driver HER2 mutations in endocrine-resistant metastatic breast cancer.
Arielle J Medford, Taronish D Dubash, +19 authors, Aditya Bardia.
NPJ Precis Oncol, 2019 Jul 26; 3. PMID: 31341951    Free PMC article.
Estrogen receptor 1 mutations in 260 cervical cancer samples from Chinese patients.
Xin-Min Yang, Zhi-Min Wu, +6 authors, Ou-Ping Huang.
Oncol Lett, 2019 Aug 28; 18(3). PMID: 31452755    Free PMC article.
Association of ESR1 Mutations and Visceral Metastasis in Patients with Estrogen Receptor-Positive Advanced Breast Cancer from Brazil.
Tomás Reinert, Guilherme Portela Coelho, +5 authors, Marcia Silveira Graudenz.
J Oncol, 2019 Sep 13; 2019. PMID: 31511774    Free PMC article.
Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor α Transcriptional Activity in Breast Cancer Cell Lines.
Matic Pavlin, Luca Gelsomino, +4 authors, Alessandra Magistrato.
Front Chem, 2019 Sep 26; 7. PMID: 31552220    Free PMC article.
Testing considerations for phosphatidylinositol-3-kinase catalytic subunit alpha as an emerging biomarker in advanced breast cancer.
Deborah L Toppmeyer, Michael F Press.
Cancer Med, 2020 Jul 23; 9(18). PMID: 32697890    Free PMC article.
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Endocrine-Resistant Breast Cancer: Mechanisms and Treatment.
Andreas D Hartkopf, Eva-Maria Grischke, Sara Y Brucker.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982644    Free PMC article.
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Genomic Signatures in Luminal Breast Cancer.
Julian Puppe, Tabea Seifert, +3 authors, Wolfram Malter.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982645    Free PMC article.
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The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome.
Christian Brueffer, Sergii Gladchuk, +12 authors, Lao H Saal.
EMBO Mol Med, 2020 Sep 15; 12(10). PMID: 32926574    Free PMC article.
The genomic landscape of metastatic histologic special types of invasive breast cancer.
Fresia Pareja, Lorenzo Ferrando, +15 authors, Jorge S Reis-Filho.
NPJ Breast Cancer, 2020 Oct 22; 6. PMID: 33083532    Free PMC article.
XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation.
David Barua, Benazir Abbasi, Ananya Gupta, Sanjeev Gupta.
Heliyon, 2020 Oct 23; 6(10). PMID: 33088967    Free PMC article.
CDK4/6 Inhibitors in Hormone Receptor-Positive Metastatic Breast Cancer: Current Practice and Knowledge.
Debora de Melo Gagliato, Antonio C Buzaid, +2 authors, Javier Cortes.
Cancers (Basel), 2020 Sep 05; 12(9). PMID: 32882980    Free PMC article.
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Src couples estrogen receptor to the anticipatory unfolded protein response and regulates cancer cell fate under stress.
Liqun Yu, Lawrence Wang, +2 authors, David J Shapiro.
Biochim Biophys Acta Mol Cell Res, 2020 Jun 06; 1867(10). PMID: 32502618    Free PMC article.
An H3K4me3 reader, BAP18 as an adaptor of COMPASS-like core subunits co-activates ERα action and associates with the sensitivity of antiestrogen in breast cancer.
Ge Sun, Chunyu Wang, +12 authors, Yue Zhao.
Nucleic Acids Res, 2020 Sep 29; 48(19). PMID: 32986841    Free PMC article.
Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells.
Megumi Funakoshi-Tago, Kenji Tago, +2 authors, Hiroomi Tamura.
Sci Rep, 2020 Nov 13; 10(1). PMID: 33177647    Free PMC article.
Breast Cancer Heterogeneity and Response to Novel Therapeutics.
Mariona Baliu-Piqué, Atanasio Pandiella, Alberto Ocana.
Cancers (Basel), 2020 Nov 11; 12(11). PMID: 33167363    Free PMC article.
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Currently Applied Molecular Assays for Identifying ESR1 Mutations in Patients with Advanced Breast Cancer.
Nuri Lee, Min-Jeong Park, +2 authors, Seri Jeong.
Int J Mol Sci, 2020 Nov 26; 21(22). PMID: 33233830    Free PMC article.
Review.
A Phase II Trial of Neoadjuvant MK-2206, an AKT Inhibitor, with Anastrozole in Clinical Stage II or III PIK3CA-Mutant ER-Positive and HER2-Negative Breast Cancer.
Cynthia X Ma, Vera Suman, +31 authors, Matthew J Ellis.
Clin Cancer Res, 2017 Sep 07; 23(22). PMID: 28874413    Free PMC article.
The emerging clinical relevance of genomics in cancer medicine.
Michael F Berger, Elaine R Mardis.
Nat Rev Clin Oncol, 2018 Mar 31; 15(6). PMID: 29599476    Free PMC article.
Highly Cited. Review.
Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents.
Elias E Stratikopoulos, Nicole Kiess, +7 authors, Ramon Parsons.
Oncogene, 2018 Aug 05; 38(1). PMID: 30076411    Free PMC article.
Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.
Tatiana Traboulsi, Mohamed El Ezzy, +2 authors, Sylvie Mader.
Oncogene, 2018 Sep 08; 38(7). PMID: 30190545    Free PMC article.
DNA damage repair defects as a new class of endocrine treatment resistance driver.
Meenakshi Anurag, Matthew J Ellis, Svasti Haricharan.
Oncotarget, 2018 Dec 18; 9(91). PMID: 30555626    Free PMC article.
High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines.
Shixiong Wang, Sachin Kumar Singh, +2 authors, Antoni Hurtado.
Int J Mol Sci, 2018 Dec 24; 19(12). PMID: 30572598    Free PMC article.
BCAS2 Enhances Carcinogenic Effects of Estrogen Receptor Alpha in Breast Cancer Cells.
Ángel Salmerón-Hernández, María Yamilet Noriega-Reyes, +2 authors, Elizabeth Langley.
Int J Mol Sci, 2019 Mar 01; 20(4). PMID: 30813351    Free PMC article.
Functional Variant rs4442975 Modulating FOXA1 Binding Affinity Can Influence Bone Marrow Suppression during Neoadjuvant Chemotherapy for Luminal A Type Breast Cancer.
Xin Wang, Zhongxin Feng, +5 authors, Yi Zhang.
Biomed Res Int, 2019 Mar 19; 2019. PMID: 30881995    Free PMC article.
Disease association of human tumor suppressor genes.
Asim Bikas Das.
Mol Genet Genomics, 2019 Apr 05; 294(4). PMID: 30945018
Everolimus in hormone receptor-positive metastatic breast cancer: PIK3CA mutation H1047R was a potential efficacy biomarker in a retrospective study.
Zongbi Yi, Fei Ma, +5 authors, Binghe Xu.
BMC Cancer, 2019 May 16; 19(1). PMID: 31088410    Free PMC article.
Genomics applied to the treatment of breast cancer.
Diaddin Hamdan, Thi Thuy Nguyen, +3 authors, Guilhem Bousquet.
Oncotarget, 2019 Aug 16; 10(46). PMID: 31413819    Free PMC article.
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The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer.
María Inés Diaz Bessone, María José Gattas, +2 authors, Marina Simian.
Front Endocrinol (Lausanne), 2019 Aug 24; 10. PMID: 31440208    Free PMC article.
Review.
Pathways to Endocrine Therapy Resistance in Breast Cancer.
Md Moquitul Haque, Kartiki V Desai.
Front Endocrinol (Lausanne), 2019 Sep 10; 10. PMID: 31496995    Free PMC article.
Review.
Ouabain and Digoxin Activate the Proteasome and the Degradation of the ERα in Cells Modeling Primary and Metastatic Breast Cancer.
Claudia Busonero, Stefano Leone, +6 authors, Filippo Acconcia.
Cancers (Basel), 2020 Dec 24; 12(12). PMID: 33352737    Free PMC article.
Detection of ESR1 Mutations Based on Liquid Biopsy in Estrogen Receptor-Positive Metastatic Breast Cancer: Clinical Impacts and Prospects.
Hao Liao, Wenfa Huang, Wendi Pei, Huiping Li.
Front Oncol, 2021 Jan 02; 10. PMID: 33384956    Free PMC article.
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Genomic control of metastasis.
Saroor A Patel, Paulo Rodrigues, Ludovic Wesolowski, Sakari Vanharanta.
Br J Cancer, 2020 Nov 05; 124(1). PMID: 33144692    Free PMC article.
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Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences.
Nolan Priedigkeit, Kai Ding, +9 authors, Adrian V Lee.
Breast Cancer Res, 2021 Jan 08; 23(1). PMID: 33407744    Free PMC article.
Significance of the Genomic Landscape of a De Novo Endocrine-Resistant Metastatic Hormone Receptor-Positive Breast Cancer.
Maithreyi Sarma, Yara Abdou, Ajay Dhakal, Shipra Gandhi.
Breast Cancer (Auckl), 2021 Jan 07; 14. PMID: 33402826    Free PMC article.
A phase Ib/II study of xentuzumab, an IGF-neutralising antibody, combined with exemestane and everolimus in hormone receptor-positive, HER2-negative locally advanced/metastatic breast cancer.
Peter Schmid, Marie-Paule Sablin, +17 authors, Javier Cortés.
Breast Cancer Res, 2021 Jan 17; 23(1). PMID: 33451345    Free PMC article.
A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses.
Léa Clusan, Pascale Le Goff, Gilles Flouriot, Farzad Pakdel.
Int J Mol Sci, 2021 Jan 17; 22(2). PMID: 33451133    Free PMC article.
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Suppression of breast cancer metastasis and extension of survival by a new antiestrogen in a preclinical model driven by mutant estrogen receptors.
Mary J Laws, Yvonne Ziegler, +8 authors, Benita S Katzenellenbogen.
Breast Cancer Res Treat, 2020 Apr 12; 181(2). PMID: 32277377    Free PMC article.
Targeting Notch in oncology: the path forward.
Samarpan Majumder, Judy S Crabtree, +3 authors, Lucio Miele.
Nat Rev Drug Discov, 2020 Dec 10; 20(2). PMID: 33293690
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Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1-Mutant Breast Cancer.
Michelle M Williams, Nicole S Spoelstra, +15 authors, Jennifer K Richer.
Cancer Res, 2020 Nov 14; 81(3). PMID: 33184106    Free PMC article.
Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects.
Spencer Arnesen, Zannel Blanchard, +5 authors, Jason Gertz.
Cancer Res, 2020 Nov 14; 81(3). PMID: 33184109    Free PMC article.
Nexus between PI3K/AKT and Estrogen Receptor Signaling in Breast Cancer.
Aditi S Khatpe, Adedeji K Adebayo, +2 authors, Harikrishna Nakshatri.
Cancers (Basel), 2021 Jan 28; 13(3). PMID: 33498407    Free PMC article.
Review.
Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes.
Lorena Lazo de la Vega, Nolan Bick, +17 authors, Paul W Harms.
Mod Pathol, 2020 May 29; 33(11). PMID: 32461624    Free PMC article.
Inference of phenotype-relevant transcriptional regulatory networks elucidates cancer type-specific regulatory mechanisms in a pan-cancer study.
Amin Emad, Saurabh Sinha.
NPJ Syst Biol Appl, 2021 Feb 10; 7(1). PMID: 33558504    Free PMC article.
AI-Driver: an ensemble method for identifying driver mutations in personal cancer genomes.
Haoxuan Wang, Tao Wang, +4 authors, Fengbiao Mao.
NAR Genom Bioinform, 2021 Feb 13; 2(4). PMID: 33575629    Free PMC article.
Mechanisms of resistance to cyclin-dependent kinase 4/6 inhibitors.
Georgia Gomatou, Ioannis Trontzas, +3 authors, Elias Kotteas.
Mol Biol Rep, 2021 Jan 08; 48(1). PMID: 33409716
Review.
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response.
Maruhen Ad Silveira, Christophe Tav, +6 authors, Steve Bilodeau.
Life Sci Alliance, 2021 Feb 18; 4(5). PMID: 33593922    Free PMC article.
Longitudinal Multi-Parametric Liquid Biopsy Approach Identifies Unique Features of Circulating Tumor Cell, Extracellular Vesicle, and Cell-Free DNA Characterization for Disease Monitoring in Metastatic Breast Cancer Patients.
Corinna Keup, Vinay Suryaprakash, +3 authors, Sabine Kasimir-Bauer.
Cells, 2021 Jan 27; 10(2). PMID: 33494385    Free PMC article.
CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer.
Pin-Shern Chen, Hui-Ping Hsu, +14 authors, Jui-Hsiang Hung.
Aging (Albany NY), 2021 Jan 19; 13(3). PMID: 33461170    Free PMC article.
Mutation analysis using cell-free DNA for endocrine therapy in patients with HR+ metastatic breast cancer.
Sung Hoon Sim, Han Na Yang, +2 authors, In Hae Park.
Sci Rep, 2021 Mar 12; 11(1). PMID: 33692409    Free PMC article.
Clinical application of circulating tumor DNA in breast cancer.
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J Cancer Res Clin Oncol, 2021 Mar 25; 147(5). PMID: 33760943
Review.
ESR1 Gene Mutation in Hormone Receptor-Positive HER2-Negative Metastatic Breast Cancer Patients: Concordance Between Tumor Tissue and Circulating Tumor DNA Analysis.
Loredana Urso, Grazia Vernaci, +12 authors, Maria Vittoria Dieci.
Front Oncol, 2021 Mar 30; 11. PMID: 33777770    Free PMC article.
Generating a Precision Endoxifen Prediction Algorithm to Advance Personalized Tamoxifen Treatment in Patients with Breast Cancer.
Thomas Helland, Sarah Alsomairy, +3 authors, Daniel Louis Hertz.
J Pers Med, 2021 Apr 04; 11(3). PMID: 33805613    Free PMC article.
Review.
Genomic landscape of extraordinary responses in metastatic breast cancer.
Sun Min Lim, Eunyoung Kim, +16 authors, Joohyuk Sohn.
Commun Biol, 2021 Apr 11; 4(1). PMID: 33837242    Free PMC article.
The deubiquitinating enzyme USP15 stabilizes ERα and promotes breast cancer progression.
Xiaohong Xia, Chuyi Huang, +8 authors, Hongbiao Huang.
Cell Death Dis, 2021 Mar 28; 12(4). PMID: 33771975    Free PMC article.
Implementation of Precision Oncology for Patients with Metastatic Breast Cancer in an Interdisciplinary MTB Setting.
Elena Sultova, C Benedikt Westphalen, +12 authors, Rachel Wuerstlein.
Diagnostics (Basel), 2021 May 01; 11(4). PMID: 33924134    Free PMC article.
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer.
Malin Dahlgren, Anthony M George, +13 authors, Lao H Saal.
JNCI Cancer Spectr, 2021 May 04; 5(2). PMID: 33937624    Free PMC article.
Single Cell Genomics for Tumor Heterogeneity.
Hae-Ock Lee, Woong-Yang Park.
Adv Exp Med Biol, 2021 May 14; 1187. PMID: 33983580
Sodium/glucose cotransporter 1-dependent metabolic alterations induce tamoxifen resistance in breast cancer by promoting macrophage M2 polarization.
Xingjian Niu, Jianli Ma, +7 authors, Qingyuan Zhang.
Cell Death Dis, 2021 May 20; 12(6). PMID: 34006822    Free PMC article.
The breast is yet to come: current and future utility of circulating tumour DNA in breast cancer.
Brad A Davidson, Sarah Croessmann, Ben H Park.
Br J Cancer, 2021 May 28;. PMID: 34040179
Review.
Genomic, Transcriptomic, and Proteomic Profiling of Metastatic Breast Cancer.
Argun Akcakanat, Xiaofeng Zheng, +11 authors, Funda Meric-Bernstam.
Clin Cancer Res, 2021 Mar 31; 27(11). PMID: 33782032    Free PMC article.
Current Landscape of Targeted Therapy in Hormone Receptor-Positive and HER2-Negative Breast Cancer.
Samitha Andrahennadi, Amer Sami, +2 authors, Shahid Ahmed.
Curr Oncol, 2021 Jun 03; 28(3). PMID: 34064867    Free PMC article.
Review.
Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?
JooYong Park, Ji-Yeob Choi, +90 authors, Daehee Kang.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34069208    Free PMC article.