Journal Article
. 2013 Nov; 6(3):213-30.
doi: 10.1007/s12307-013-0138-y.

Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases

Dongwei Gao 1 Sha Li  
Affiliations
  • PMID: 24214411
  •     230 References
  •     3 citations

Abstract

Many hypotheses have been proposed to try to explain cancer metastasis. However, they seem to be contradictory and have some limitations. Comparisons of primary tumors and matched metastases provide new insight into metastasis. The results show high concordances and minor differences at multiple scales from organic level to molecular level. The concordances reflect the commonality between primary cancer and metastasis, and also mean that metastatic cancer cells derived from primary cancer are quite conservative in distant sites. The differences reflect variation that cancer cells must acquire new traits to adapt to foreign milieu during the course of evolving into a new tumor in second organs. These comparisons also provided new information on understanding mechanism of vascular metastasis, organ-specific metastasis, and tumor dormancy. The collective results suggest a new hypothesis, biological resonance (bio-resonance) model. The hypothesis has two aspects. One is that primary cancer and matched metastasis have a common progenitor. The other is that both ancestors of primary cancer cells and metastatic cancer cells are under similar microenvironments and receive similar or same signals. When their interactions reach a status similar to primary cancer, metastasis will occur. Compared with previous hypotheses, the bio-resonance hypothesis seems to be more applicable for cancer metastasis to explain how, when and where metastasis occurs. Thus, it has important implications for individual prediction, prevention and treatment of cancer metastasis.

Lung-residing metastatic and dormant neuroblastoma cells.
Liat Edry Botzer, Shelly Maman, +5 authors, Isaac P Witz.
Am J Pathol, 2011 Jun 28; 179(1). PMID: 21703429    Free PMC article.
Comparison of p53 and epidermal growth factor receptor gene status between primary tumors and lymph node metastases in non-small cell lung cancers.
Yih-Leong Chang, Chen-Tu Wu, Jin-Yuan Shih, Yung-Chie Lee.
Ann Surg Oncol, 2010 Sep 03; 18(2). PMID: 20811949
The patterns and dynamics of genomic instability in metastatic pancreatic cancer.
Peter J Campbell, Shinichi Yachida, +22 authors, P Andrew Futreal.
Nature, 2010 Oct 29; 467(7319). PMID: 20981101    Free PMC article.
Highly Cited.
Tumor-microenvironment interactions: dangerous liaisons.
Isaac P Witz.
Adv Cancer Res, 2008 Jul 16; 100. PMID: 18620097
Review.
Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification.
Marta Alonso Guervós, César Alvarez Marcos, +3 authors, Mario Hermsen.
Oral Oncol, 2008 Oct 28; 45(7). PMID: 18952489
Comparison of EGFR and KRAS mutations in primary and unpaired metastatic lung adenocarcinoma with potential chemotherapy effect.
Delicia Munfus-McCray, Min Cui, +3 authors, Qing Kay Li.
Hum Pathol, 2013 Jan 23; 44(7). PMID: 23337026
Genetic and epigenetic alterations in sentinel lymph nodes metastatic lesions compared to their corresponding primary breast tumors.
Luciane R Cavalli, Cícero A Urban, +8 authors, Bassem R Haddad.
Cancer Genet Cytogenet, 2003 Sep 23; 146(1). PMID: 14499694
Discordance of genetic alterations between primary head and neck tumors and corresponding metastases associated with mutational status of the TP53 gene.
Maarten P Tabor, Viola M M van Houten, +6 authors, Ruud H Brakenhoff.
Genes Chromosomes Cancer, 2002 Jan 17; 33(2). PMID: 11793443
The genomic relationship between primary breast carcinomas and their nodal metastases.
Mohamed M Desouki, Shaoxi Liao, +4 authors, Joseph Geradts.
Cancer Invest, 2011 Apr 08; 29(4). PMID: 21469979
Gene expression profiling of human lymph node metastases and matched primary breast carcinomas: clinical implications.
Mika Suzuki, David Tarin.
Mol Oncol, 2007 Sep 01; 1(2). PMID: 19383293    Free PMC article.
Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer.
Britta Weigelt, Zhiyuan Hu, +6 authors, Laura J Van't Veer.
Cancer Res, 2005 Oct 19; 65(20). PMID: 16230372
Highly Cited.
Molecular basis of metastasis.
Anne C Chiang, Joan Massagué.
N Engl J Med, 2008 Dec 26; 359(26). PMID: 19109576    Free PMC article.
Highly Cited. Review.
Comparison of genetic changes in primary sarcomas and their pulmonary metastases.
M Tarkkanen, R Huuhtanen, +6 authors, S Knuutila.
Genes Chromosomes Cancer, 1999 Jul 09; 25(4). PMID: 10398425
Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases.
M Koda, M Sulkowska, L Kanczuga-Koda, S Sulkowski.
J Clin Pathol, 2005 May 27; 58(6). PMID: 15917419    Free PMC article.
Omics-based profiling of carcinoma of the breast and matched regional lymph node metastasis.
Jian Li, Pavel Gromov, +11 authors, Julio E Celis.
Proteomics, 2008 Nov 13; 8(23-24). PMID: 19003862
Fluorescence in situ hybridization analysis of matched primary tumour and lymph-node metastasis of D1 (pT2-3pN1M0) prostate cancer.
Antonio Alcaraz, Juan M Corral, +5 authors, Humberto Villavicencio.
BJU Int, 2004 Aug 05; 94(3). PMID: 15291877
Predicting biomarkers for ovarian cancer using gene-expression microarrays.
T R Adib, S Henderson, +4 authors, C Boshoff.
Br J Cancer, 2004 Feb 05; 90(3). PMID: 14760385    Free PMC article.
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.
Sean J Morrison, Allan C Spradling.
Cell, 2008 Feb 26; 132(4). PMID: 18295578    Free PMC article.
Highly Cited. Review.
Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases.
Hidekazu Kuramochi, Kazuhiko Hayashi, +4 authors, Peter V Danenberg.
Cancer Chemother Pharmacol, 2009 Aug 25; 65(5). PMID: 19701635
Translating the metastasis paradigm from scientific theory to clinical oncology.
Fei Dong, Anuradha S Budhu, Xin Wei Wang.
Clin Cancer Res, 2009 Apr 09; 15(8). PMID: 19351761    Free PMC article.
Circulating tumor cells and bone marrow micrometastasis.
Catherine Alix-Panabières, Sabine Riethdorf, Klaus Pantel.
Clin Cancer Res, 2008 Aug 14; 14(16). PMID: 18698019
Review.
5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis.
Hidekazu Kuramochi, Kazuhiko Hayashi, +7 authors, Peter V Danenberg.
Int J Cancer, 2006 Mar 31; 119(3). PMID: 16572420
Antigenic profiles of individual-matched pairs of primary and melanoma metastases.
Clifton B Meije, Guido W M Swart, +2 authors, Joost J Van den Oord.
Hum Pathol, 2009 Apr 24; 40(10). PMID: 19386352
Cigarette smoking and the risk of pulmonary metastasis from breast cancer.
S Murin, J Inciardi.
Chest, 2001 Jun 16; 119(6). PMID: 11399684
Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer.
Thomas Knösel, Karsten Schlüns, +4 authors, Iver Petersen.
Neoplasia, 2004 Apr 08; 6(1). PMID: 15068668    Free PMC article.
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.
Howard Y Chang, Dimitry S A Nuyten, +10 authors, Marc J van de Vijver.
Proc Natl Acad Sci U S A, 2005 Feb 11; 102(10). PMID: 15701700    Free PMC article.
Highly Cited.
The metastatic microenvironment: lung-derived factors control the viability of neuroblastoma lung metastasis.
Shelly Maman, Liat Edry-Botzer, +4 authors, Isaac P Witz.
Int J Cancer, 2013 May 08; 133(10). PMID: 23649556
Role of nervous system in cancer aetiopathogenesis.
Katarina Ondicova, Boris Mravec.
Lancet Oncol, 2010 Jun 05; 11(6). PMID: 20522385
Review.
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
Ji Hun Kim, Eun Ji Jung, +2 authors, Woo Ho Kim.
Oncol Rep, 2009 Apr 11; 21(5). PMID: 19360301
Clonal relationships between epidermotropic metastatic melanomas and their primary lesions: a loss of heterozygosity and X-chromosome inactivation-based analysis.
Soon Bahrami, Liang Cheng, +3 authors, Steven D Billings.
Mod Pathol, 2007 Jun 16; 20(8). PMID: 17571079
Early origin of cancer metastases: dissemination and evolution of premalignant cells.
Stéphane Ansieau, George Hinkal, +2 authors, Alain Puisieux.
Cell Cycle, 2008 Nov 26; 7(23). PMID: 19029812
Review.
Socializing with the neighbors: stem cells and their niche.
Elaine Fuchs, Tudorita Tumbar, Geraldine Guasch.
Cell, 2004 Mar 24; 116(6). PMID: 15035980
Highly Cited. Review.
The role played by the microenvironment in site-specific metastasis.
Anat Klein-Goldberg, Shelly Maman, Isaac P Witz.
Cancer Lett, 2013 Aug 31; 352(1). PMID: 23988268
Review.
Cancer of Unknown Primary Origin.
Briasoulis, Pavlidis.
Oncologist, 1997 Jan 01; 2(3). PMID: 10388044
A molecular signature of metastasis in primary solid tumors.
Sridhar Ramaswamy, Ken N Ross, Eric S Lander, Todd R Golub.
Nat Genet, 2002 Dec 07; 33(1). PMID: 12469122
Highly Cited.
Differential protein expression in primary breast cancer and matched axillary node metastasis.
Phatcharaporn Thongwatchara, Waraporn Promwikorn, +3 authors, Paramee Thongsuksai.
Oncol Rep, 2011 Apr 20; 26(1). PMID: 21503584
Parallel progression of primary tumours and metastases.
Christoph A Klein.
Nat Rev Cancer, 2009 Mar 25; 9(4). PMID: 19308069
Highly Cited. Review.
p53 mutations in matched primary and metastatic human tumors.
S Peller, A Halevy, +2 authors, V Rotter.
Mol Carcinog, 1995 Jul 01; 13(3). PMID: 7619219
Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.
Yingjie Wu, Pnina Brodt, +8 authors, Shoshana Yakar.
Cancer Res, 2010 Jan 06; 70(1). PMID: 20048072    Free PMC article.
Tumour seeding in peritoneal wound sites in relation to growth-factor expression in early granulation tissue.
S Zeamari, E Roos, F A Stewart.
Eur J Cancer, 2004 Jun 05; 40(9). PMID: 15177504
Cancer. Targeting lymphatic metastasis.
Jeffrey E Gershenwald, Isaiah J Fidler.
Science, 2002 Jun 08; 296(5574). PMID: 12052939
HER2 discordance between primary breast cancer and its paired metastasis: tumor biology or test artefact? Insights through meta-analysis.
Nehmat Houssami, Petra Macaskill, +2 authors, Mark D Pegram.
Breast Cancer Res Treat, 2011 Jun 24; 129(3). PMID: 21698410
Systematic Review.
Liver regeneration stimulates tumor metastases.
Nadia Harun, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Christopher Christophi.
J Surg Res, 2007 Jan 27; 138(2). PMID: 17254608
Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases.
F Al-Mulla, W N Keith, +2 authors, G D Birnie.
Genes Chromosomes Cancer, 1999 Mar 26; 24(4). PMID: 10092128
Gene expression profiling predicts clinical outcome of breast cancer.
Laura J van 't Veer, Hongyue Dai, +13 authors, Stephen H Friend.
Nature, 2002 Feb 02; 415(6871). PMID: 11823860
Highly Cited.
Genomic instability--an evolving hallmark of cancer.
Simona Negrini, Vassilis G Gorgoulis, Thanos D Halazonetis.
Nat Rev Mol Cell Biol, 2010 Feb 24; 11(3). PMID: 20177397
Highly Cited. Review.
Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction.
Ian B Nicoud, Christopher M Jones, +4 authors, D Lee Gorden.
Cancer Res, 2007 Mar 17; 67(6). PMID: 17363593
Comparison of losses of heterozygosity and replication errors in primary colorectal carcinomas and corresponding liver metastases.
H Bläker, M Graf, R J Rieker, H F Otto.
J Pathol, 1999 Jul 27; 188(3). PMID: 10419592
Cancer stem cells and metastasis: lethal seeds.
Max S Wicha.
Clin Cancer Res, 2006 Oct 06; 12(19). PMID: 17020960
Correlation between genetic and biological aspects in primary non-metastatic breast cancers and corresponding synchronous axillary lymph node metastasis.
Mario R D'Andrea, Maria R Limiti, +7 authors, Pietro L Mingazzini.
Breast Cancer Res Treat, 2006 Jul 13; 101(3). PMID: 16835704
Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch.
George N Naumov, Lars A Akslen, Judah Folkman.
Cell Cycle, 2006 Aug 26; 5(16). PMID: 16931911
Highly Cited. Review.
Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases.
Stephan E Baldus, Karl-L Schaefer, +3 authors, Helmut E Gabbert.
Clin Cancer Res, 2010 Jan 28; 16(3). PMID: 20103678
Highly Cited.
Breast metastasis 56 months before the diagnosis of primary ovarian cancer: a case study.
Susanne E Schneuber, Heinz S Scholz, +2 authors, Raimund Winter.
Anticancer Res, 2008 Nov 27; 28(5B). PMID: 19031954
Comparison between the nuclear diameters of primary and metastatic breast cancer cells obtained by cytologic aspiration.
A Zajdela, B Asselain, N A Ghossein.
Cancer, 1985 Oct 01; 56(7). PMID: 2992740
Effects of injury and repair of the pulmonary endothelium on lung metastasis after bleomycin.
I Y Adamson, F W Orr, L Young.
J Pathol, 1986 Dec 01; 150(4). PMID: 2433421
Circulating tumor cells are transcriptionally similar to the primary tumor in a murine prostate model.
Kimberly T Helzer, Helen E Barnes, +3 authors, Allyn Forsyth.
Cancer Res, 2009 Oct 01; 69(19). PMID: 19789350
Delineation of the infrequent mosaicism of KRAS mutational status in metastatic colorectal adenocarcinomas.
Céline Bossard, Sébastien Küry, +7 authors, Jean-François Mosnier.
J Clin Pathol, 2012 Jan 20; 65(5). PMID: 22259183
KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients.
N Knijn, L J M Mekenkamp, +9 authors, I D Nagtegaal.
Br J Cancer, 2011 Mar 03; 104(6). PMID: 21364579    Free PMC article.
Highly Cited.
The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo.
Jodie M Fleming, Tyler C Miller, +6 authors, Barbara K Vonderhaar.
BMC Med, 2010 May 25; 8. PMID: 20492690    Free PMC article.
Comparison of HER2 status in primary and paired metastatic sites of gastric carcinoma.
C Bozzetti, F V Negri, +12 authors, A Ardizzoni.
Br J Cancer, 2011 Apr 14; 104(9). PMID: 21487407    Free PMC article.
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis.
John M Pawelek, Ashok K Chakraborty.
Nat Rev Cancer, 2008 Apr 04; 8(5). PMID: 18385683
Highly Cited. Review.
Cancer. The metastasis cascade.
Christoph A Klein.
Science, 2008 Sep 27; 321(5897). PMID: 18818347
Clonal selection of metastasis within the life history of a tumor.
James E Talmadge.
Cancer Res, 2007 Dec 20; 67(24). PMID: 18089772
Review.
Glutathione S-transferases in liver metastases of colorectal cancer. A comparison with normal liver and primary carcinomas.
T P Mulder, H M Roelofs, +3 authors, H W Verspaget.
Carcinogenesis, 1994 Oct 01; 15(10). PMID: 7955047
Patterned distribution of metastases from malignant melanoma in humans.
S M de la Monte, G W Moore, G M Hutchins.
Cancer Res, 1983 Jul 01; 43(7). PMID: 6850649
Tumor dormancy of primary and secondary cancers.
Taturo Udagawa.
APMIS, 2008 Oct 07; 116(7-8). PMID: 18834406
Review.
Comparison of estrogen receptors, progesterone receptors and HER-2/neu expression between primary and metastatic breast carcinoma.
Muhammad Azam, Asim Qureshi, Samina Mansoor.
J Pak Med Assoc, 2010 Apr 07; 59(11). PMID: 20361669
Influence of smoking on the development of lung metastases from breast cancer.
E F Scanlon, O Suh, +3 authors, K M Cummings.
Cancer, 1995 Jun 01; 75(11). PMID: 7743472
Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases.
S J Aitken, J S Thomas, +2 authors, D Faratian.
Ann Oncol, 2009 Oct 28; 21(6). PMID: 19858088
Development of brain metastasis 5 years before the appearance of the primary lung cancer: "messenger metachronous metastasis".
József Furák, Imre Troján, +2 authors, László G Puskás.
Ann Thorac Surg, 2003 Mar 21; 75(3). PMID: 12645740
CGH pattern of esthesioneuroblastoma and their metastases.
Ulrike Bockmühl, Xuejun You, +3 authors, Iver Petersen.
Brain Pathol, 2004 Jun 15; 14(2). PMID: 15193028    Free PMC article.
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.
Isaiah J Fidler.
Nat Rev Cancer, 2003 Jun 05; 3(6). PMID: 12778135
Highly Cited.
Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases--an analysis by comparative genomic hybridization.
Jeng-Kai Jiang, Yann-Jang Chen, +2 authors, Jen-Kou Lin.
Genes Chromosomes Cancer, 2005 Feb 22; 43(1). PMID: 15723340
Reduced expression of nm23 protein is associated with advanced tumor stage and distant metastases in human colorectal carcinomas.
A Ayhan, W Yasui, +2 authors, E Tahara.
Virchows Arch B Cell Pathol Incl Mol Pathol, 1993 Jan 01; 63(4). PMID: 8099459
HLA ligand profiles of primary renal cell carcinoma maintained in metastases.
Juliane Sarah Stickel, Andreas O Weinzierl, +8 authors, Stefan Stevanović.
Cancer Immunol Immunother, 2009 Feb 03; 58(9). PMID: 19184600
Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma.
P P Leong, B Rezai, +6 authors, W H Westra.
J Natl Cancer Inst, 1998 Jul 17; 90(13). PMID: 9665144
Cigarette smoking and risk of lung metastasis from esophageal cancer.
Julian A Abrams, Paul C Lee, +2 authors, Alfred I Neugut.
Cancer Epidemiol Biomarkers Prev, 2008 Oct 10; 17(10). PMID: 18843013    Free PMC article.
Genome remodelling in a basal-like breast cancer metastasis and xenograft.
Li Ding, Matthew J Ellis, +66 authors, Elaine R Mardis.
Nature, 2010 Apr 16; 464(7291). PMID: 20393555    Free PMC article.
Highly Cited.
Comparison of chemokine and receptor gene expression between Wharton's jelly and bone marrow-derived mesenchymal stromal cells.
Sudha Balasubramanian, Parvathy Venugopal, +3 authors, Malancha Ta.
Cytotherapy, 2011 Nov 19; 14(1). PMID: 22091833
Tumour-cell fusion as a source of myeloid traits in cancer.
John M Pawelek.
Lancet Oncol, 2005 Dec 03; 6(12). PMID: 16321767
Review.
'Prechronous' metastasis in clear cell renal cell carcinoma: a case report.
Eileen Poon, Sin Jen Ong, +6 authors, Min-Han Tan.
J Med Case Rep, 2011 May 17; 5. PMID: 21569512    Free PMC article.
Metastasis: recent discoveries and novel treatment strategies.
Suzanne A Eccles, Danny R Welch.
Lancet, 2007 May 22; 369(9574). PMID: 17512859    Free PMC article.
Highly Cited. Review.
EblacZ tumor dormancy in bone marrow and lymph nodes: active control of proliferating tumor cells by CD8+ immune T cells.
M Müller, F Gounari, +3 authors, K Khazaie.
Cancer Res, 1998 Dec 16; 58(23). PMID: 9850077
Evidence emerges for early metastasis and parallel evolution of primary and metastatic tumors.
Joe W Gray.
Cancer Cell, 2003 Aug 02; 4(1). PMID: 12892707
Analysis of paired primary lung and lymph node tumor cells: a model of metastatic potential by multiple genetic programs.
Chuong D Hoang, Tenner J Guillaume, +3 authors, Michael A Maddaus.
Cancer Detect Prev, 2005 Nov 18; 29(6). PMID: 16289389
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer.
Fotios Loupakis, Luca Pollina, +17 authors, Alfredo Falcone.
J Clin Oncol, 2009 Apr 29; 27(16). PMID: 19398573
Highly Cited.
DNA index and cell cycle analysis of primary breast cancer and synchronous axillary lymph node metastases.
G E Feichter, M Kaufmann, +3 authors, K Goerttler.
Breast Cancer Res Treat, 1989 Jan 01; 13(1). PMID: 2706325
Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.
John Condeelis, Jeffrey W Pollard.
Cell, 2006 Jan 28; 124(2). PMID: 16439202
Highly Cited. Review.
Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis.
Nikolas H Stoecklein, Christoph A Klein.
Int J Cancer, 2009 Oct 02; 126(3). PMID: 19795462
Review.
Beyond tumorigenesis: cancer stem cells in metastasis.
Feng Li, Benjamin Tiede, Joan Massagué, Yibin Kang.
Cell Res, 2006 Dec 21; 17(1). PMID: 17179981
Highly Cited. Review.
Copy number variation analysis of matched ovarian primary tumors and peritoneal metastasis.
Joel A Malek, Eliane Mery, +8 authors, Arash Rafii.
PLoS One, 2011 Dec 24; 6(12). PMID: 22194851    Free PMC article.
High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice.
Daniele Santini, Fotios Loupakis, +17 authors, Annamaria Ruzzo.
Oncologist, 2008 Dec 06; 13(12). PMID: 19056857
Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastatic to liver, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization.
W M Korn, T Yasutake, +5 authors, F M Waldman.
Genes Chromosomes Cancer, 1999 May 25; 25(2). PMID: 10337990
Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma.
Jo Eyles, Anne-Laure Puaux, +12 authors, Jean-Pierre Abastado.
J Clin Invest, 2010 May 27; 120(6). PMID: 20501944    Free PMC article.
Highly Cited.
Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases.
D J Mole, C O'Neill, +6 authors, F C Campbell.
Br J Cancer, 2011 Feb 24; 104(6). PMID: 21343932    Free PMC article.
The distribution of secondary growths in cancer of the breast. 1889.
S Paget.
Cancer Metastasis Rev, 1989 Aug 01; 8(2). PMID: 2673568
Highly Cited.
DNA flow cytometry of primary tumors and their skin metastases. Correlation of DNA histograms.
T J Flotte, C Pastel-Levy, +2 authors, D A Bell.
Am J Dermatopathol, 1992 Feb 01; 14(1). PMID: 1510211
Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung.
Anna G Taranova, David Maldonado, +11 authors, James J Lee.
Cancer Res, 2008 Oct 17; 68(20). PMID: 18922934    Free PMC article.
Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse.
J Chuck Harrell, Aleix Prat, +6 authors, Charles M Perou.
Breast Cancer Res Treat, 2011 Jun 15; 132(2). PMID: 21671017    Free PMC article.
Highly Cited.
A metastatic signature in entire lung adenocarcinomas irrespective of morphological heterogeneity.
Kentaro Inamura, Takashi Shimoji, +8 authors, Yuichi Ishikawa.
Hum Pathol, 2007 Mar 23; 38(5). PMID: 17376511
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
S Li, R Rosell, +6 authors, M Monzo.
Lung Cancer, 1994 Jul 01; 11(1-2). PMID: 8081702
The neuro-neoplastic synapse: does it exist?
Kurt S Zänker.
Prog Exp Tumor Res, 2007 Feb 23; 39. PMID: 17314507
Review.
Comparison between epidermal growth factor receptor (EGFR) gene expression in primary non-small cell lung cancer (NSCLC) and in fine-needle aspirates from distant metastatic sites.
Cecilia Bozzetti, Marcello Tiseo, +11 authors, Andrea Ardizzoni.
J Thorac Oncol, 2008 Jan 02; 3(1). PMID: 18166836
Dynamic heterogeneity: rapid generation of metastatic variants in mouse B16 melanoma cells.
R P Hill, A F Chambers, V Ling, J F Harris.
Science, 1984 Jun 01; 224(4652). PMID: 6719130
Microenvironmental regulation of metastasis.
Johanna A Joyce, Jeffrey W Pollard.
Nat Rev Cancer, 2009 Mar 13; 9(4). PMID: 19279573    Free PMC article.
Highly Cited. Review.
Current and emerging concepts in tumour metastasis.
Caroline Coghlin, Graeme I Murray.
J Pathol, 2010 Aug 04; 222(1). PMID: 20681009
Highly Cited. Review.
Brain metastasis: opportunities in basic and translational research.
Elizabeth A Maher, Judy Mietz, +2 authors, Suresh Mohla.
Cancer Res, 2009 Jul 30; 69(15). PMID: 19638593
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.
Rosandra N Kaplan, Rebecca D Riba, +18 authors, David Lyden.
Nature, 2005 Dec 13; 438(7069). PMID: 16341007    Free PMC article.
Highly Cited.
Seeding and propagation of untransformed mouse mammary cells in the lung.
Katrina Podsypanina, Yi-Chieh Nancy Du, +3 authors, Harold Varmus.
Science, 2008 Aug 30; 321(5897). PMID: 18755941    Free PMC article.
Highly Cited.
[Cellular DNA determination and its significance in the identification of tumor recurrences, metastases and second primary tumors].
Z Szentirmay, N Udvarhelyi, I Besznyák.
Orv Hetil, 1992 Aug 09; 133(32). PMID: 1501852
Discordance of p53 status in matched primary tumours and metastases in head and neck squamous cell carcinoma patients.
A Kropveld, A D van Mansfeld, +2 authors, P J Slootweg.
Eur J Cancer B Oral Oncol, 1996 Nov 01; 32B(6). PMID: 9039222
Cancer metastasis scrutinized.
Elie Dolgin.
Nature, 2009 Oct 16; 461(7266). PMID: 19829337
Systemic cancer progression and tumor dormancy: mathematical models meet single cell genomics.
Christoph A Klein, Dieter Hölzel.
Cell Cycle, 2006 Aug 25; 5(16). PMID: 16929175
A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype.
George N Naumov, Elise Bender, +8 authors, Nava Almog.
J Natl Cancer Inst, 2006 Mar 02; 98(5). PMID: 16507828
Highly Cited.
Comparison of DNA aneuploidy of primary and metastatic spontaneous canine osteosarcomas.
M H Fox, L W Armstrong, +4 authors, E L Gillette.
Cancer Res, 1990 Oct 01; 50(19). PMID: 2400984
Chromosomal alterations in lung metastases of colorectal carcinomas: associations with tissue specific tumor dissemination.
Thomas Knösel, Karsten Schlüns, Manfred Dietel, Iver Petersen.
Clin Exp Metastasis, 2006 Feb 14; 22(7). PMID: 16475023
The effect of cigarette smoke exposure on pulmonary metastatic disease in a murine model of metastatic breast cancer.
Susan Murin, Kent E Pinkerton, Neil E Hubbard, Kent Erickson.
Chest, 2004 Apr 14; 125(4). PMID: 15078760
Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer.
Pamela L Paris, Matthias D Hofer, +8 authors, Colin Collins.
Neoplasia, 2007 Jan 16; 8(12). PMID: 17217626    Free PMC article.
Clonal and parallel evolution of primary lung cancers and their metastases revealed by molecular dissection of cancer cells.
Kenji Takahashi, Takashi Kohno, +6 authors, Jun Yokota.
Clin Cancer Res, 2007 Jan 04; 13(1). PMID: 17200345
Stat3 regulates genes common to both wound healing and cancer.
Daniel J Dauer, Bernadette Ferraro, +6 authors, Eric B Haura.
Oncogene, 2005 Mar 01; 24(21). PMID: 15735721
Highly Cited.
Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study.
Kristine H Allin, Børge G Nordestgaard, Henrik Flyger, Stig E Bojesen.
Breast Cancer Res, 2011 Jun 07; 13(3). PMID: 21639875    Free PMC article.
Clonal origin of lymph node metastases in bladder carcinoma.
Timothy D Jones, Matthew D Carr, +3 authors, Liang Cheng.
Cancer, 2005 Oct 01; 104(9). PMID: 16196038
Pancreatic tissue in the wall of the small intestine.
I H OGILVY.
Aust N Z J Surg, 1951 Feb 01; 20(3). PMID: 14820711
Whole genome sequencing of matched primary and metastatic acral melanomas.
Samra Turajlic, Simon J Furney, +13 authors, Richard Marais.
Genome Res, 2011 Dec 21; 22(2). PMID: 22183965    Free PMC article.
p53 tumor suppressor gene as a clonal marker in head and neck squamous cell carcinoma: p53 mutations in primary tumor and matched lymph node metastases.
G W Tjebbes, F G Leppers vd Straat, +2 authors, P J Slootweg.
Oral Oncol, 2000 Jan 25; 35(4). PMID: 10645403
HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors.
Menghong Sun, Carmen Behrens, +8 authors, Ignacio I Wistuba.
Clin Cancer Res, 2009 Jul 23; 15(15). PMID: 19622585    Free PMC article.
Variants in tamoxifen metabolizing genes: a case-control study of contralateral breast cancer risk in the WECARE study.
Jennifer D Brooks, Sharon N Teraoka, +12 authors, Jane C Figueiredo.
Int J Mol Epidemiol Genet, 2013 Apr 09; 4(1). PMID: 23565321    Free PMC article.
KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.
Jeanne Tie, Lara Lipton, +21 authors, Oliver M Sieber.
Clin Cancer Res, 2011 Jan 18; 17(5). PMID: 21239505
The cancer cell--leukocyte fusion theory of metastasis.
John M Pawelek, Ashok K Chakraborty.
Adv Cancer Res, 2008 Dec 06; 101. PMID: 19055949
Review.
Cancer research. Inflammation and cancer: the link grows stronger.
Jean Marx.
Science, 2004 Nov 06; 306(5698). PMID: 15528423
A model of port-site metastases of gallbladder cancer: the influence of peritoneal injury and its repair on abdominal wall metastases.
Y Aoki, H Shimura, +3 authors, M Tanaka.
Surgery, 1999 May 20; 125(5). PMID: 10330945
Multiple biomarker expression on circulating tumor cells in comparison to tumor tissues from primary and metastatic sites in patients with locally advanced/inflammatory, and stage IV breast cancer, using a novel detection technology.
George Somlo, Sean K Lau, +5 authors, Richard H Bruce.
Breast Cancer Res Treat, 2011 Apr 19; 128(1). PMID: 21499685    Free PMC article.
Metastasis results from preexisting variant cells within a malignant tumor.
I J Fidler, M L Kripke.
Science, 1977 Aug 26; 197(4306). PMID: 887927
Highly Cited.
Enhancement of pulmonary metastasis of murine fibrosarcoma NR-FS by ozone exposure.
T Kobayashi, T Todoroki, H Sato.
J Toxicol Environ Health, 1987 Jan 01; 20(1-2). PMID: 3806700
Inflammation and cancer: back to Virchow?
F Balkwill, A Mantovani.
Lancet, 2001 Mar 07; 357(9255). PMID: 11229684
Highly Cited. Review.
From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression.
Oleg Schmidt-Kittler, Thomas Ragg, +13 authors, Christoph A Klein.
Proc Natl Acad Sci U S A, 2003 Jun 17; 100(13). PMID: 12808139    Free PMC article.
Highly Cited.
The clonal evolution of tumor cell populations.
P C Nowell.
Science, 1976 Oct 01; 194(4260). PMID: 959840
Highly Cited.
Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype.
Marija Balic, Henry Lin, +5 authors, Richard J Cote.
Clin Cancer Res, 2006 Oct 06; 12(19). PMID: 17020963
Highly Cited.
Comparison of DNA content in gastric cancer cells between primary lesions and lymph node metastases.
H Baba, D Korenaga, T Okamura, K Sugimachi.
Cancer, 1990 Oct 15; 66(8). PMID: 2208034
Flow cytometric analysis of DNA aneuploidy in primary and metastatic human solid tumors.
O S Frankfurt, H K Slocum, +6 authors, W R Greco.
Cytometry, 1984 Jan 01; 5(1). PMID: 6199167
Systemic inflammatory response associated with distant metastasis of T1 or T2 colorectal cancer.
Mitsuru Ishizuka, Hitoshi Nagata, Kazutoshi Takagi, Keiichi Kubota.
Dig Dis Sci, 2010 Mar 04; 55(11). PMID: 20198429
Metastasis: from dissemination to organ-specific colonization.
Don X Nguyen, Paula D Bos, Joan Massagué.
Nat Rev Cancer, 2009 Mar 25; 9(4). PMID: 19308067
Highly Cited. Review.
Cytogenetic findings in metastases from colorectal cancer.
G Bardi, L A Parada, +7 authors, S Heim.
Int J Cancer, 1997 Aug 07; 72(4). PMID: 9259398
Tracing the origins of metastasis.
Don X Nguyen.
J Pathol, 2010 Dec 03; 223(2). PMID: 21125675
Review.
Tumor interactions with soluble factors and the nervous system.
Melanie J Voss, Frank Entschladen.
Cell Commun Signal, 2010 Sep 09; 8. PMID: 20822525    Free PMC article.
The tumor microenvironment: the making of a paradigm.
Isaac P Witz.
Cancer Microenviron, 2009 Aug 25; 2 Suppl 1. PMID: 19701697    Free PMC article.
Distant metastasis of renal adenocarcinoma.
H Saitoh.
Cancer, 1981 Sep 15; 48(6). PMID: 7272969
Highly Cited.
Whole genome analysis for liver metastasis gene signatures in colorectal cancer.
Dong Hyuk Ki, Hei-Cheul Jeung, +6 authors, Sun Young Rha.
Int J Cancer, 2007 Jul 21; 121(9). PMID: 17640062
p53, BCL-2 and BAX in non-small cell lung cancer brain metastases: a comparison of real-time RT-PCR, ELISA and immunohistochemical techniques.
Andreas M Stark, Heinz-Herrmann Hugo, Hauke Tscheslog, H Maximilian Mehdorn.
Neurol Res, 2007 May 31; 29(5). PMID: 17535549
Genetic determinants of cancer metastasis.
Don X Nguyen, Joan Massagué.
Nat Rev Genet, 2007 Apr 19; 8(5). PMID: 17440531
Highly Cited. Review.
Comparison of nuclear DNA content in primary and metastatic differentiated thyroid carcinoma.
H Joensuu, P J Klemi.
Am J Clin Pathol, 1988 Jan 01; 89(1). PMID: 3337050
PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer.
Ana M Gonzalez-Angulo, Jaime Ferrer-Lozano, +9 authors, Funda Meric-Bernstam.
Mol Cancer Ther, 2011 Apr 15; 10(6). PMID: 21490305    Free PMC article.
Highly Cited.
A comparison of EGFR and KRAS status in primary lung carcinoma and matched metastases.
Sara E Monaco, Marina N Nikiforova, +3 authors, Sanja Dacic.
Hum Pathol, 2009 Sep 11; 41(1). PMID: 19740513
Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanoma.
Terrence M Katona, Timothy D Jones, +3 authors, Liang Cheng.
Am J Surg Pathol, 2007 Jun 27; 31(7). PMID: 17592269
KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications.
Antoine Italiano, Isabelle Hostein, +10 authors, Florence Pedeutour.
Ann Surg Oncol, 2010 Jan 06; 17(5). PMID: 20049644
DNA content and prognosis in renal cell carcinoma. A comparison between primary tumors and metastases.
B Ljungberg, R Stenling, G Roos.
Cancer, 1986 Jun 15; 57(12). PMID: 3697934
HER-2 amplification is highly homogenous in gastric cancer.
Andreas H Marx, Lars Tharun, +9 authors, Guido Sauter.
Hum Pathol, 2009 Mar 10; 40(6). PMID: 19269014
Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases.
Bernhard C Danner, Jan S Gerdes, +8 authors, Laszlo Füzesi.
Cancer Genet, 2011 Apr 21; 204(3). PMID: 21504711
The metastatic microenvironment: brain-residing melanoma metastasis and dormant micrometastasis.
Sivan Izraely, Orit Sagi-Assif, +9 authors, Isaac P Witz.
Int J Cancer, 2011 Oct 26; 131(5). PMID: 22025079
EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases.
Katharina Schmid, Natalie Oehl, +3 authors, Martin Filipits.
Clin Cancer Res, 2009 Jul 09; 15(14). PMID: 19584155
Highly Cited.
Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma.
Molly Yancovitz, Adam Litterman, +9 authors, David Polsky.
PLoS One, 2012 Jan 12; 7(1). PMID: 22235286    Free PMC article.
Highly Cited.
Chronic inflammation and breast cancer recurrence.
Steven W Cole.
J Clin Oncol, 2009 May 28; 27(21). PMID: 19470918    Free PMC article.
Concordant analysis of KRAS status in primary colon carcinoma and matched metastasis.
Pascale Mariani, Marick Lae, +10 authors, Patricia De Cremoux.
Anticancer Res, 2010 Nov 03; 30(10). PMID: 21036746
Differential gene and protein expression in primary gastric carcinomas and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis.
Hai Long Xie, Zhi Yu Li, +4 authors, Xiu Tian Zhou.
J Dig Dis, 2010 Jun 29; 11(3). PMID: 20579220
Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors.
Ganepola A P Ganepola, Robert M Mazziotta, +8 authors, John M Mariadason.
Clin Exp Metastasis, 2009 Nov 03; 27(1). PMID: 19882219
A gene expression signature that defines breast cancer metastases.
Rachel E Ellsworth, Jeff Seebach, +5 authors, Craig D Shriver.
Clin Exp Metastasis, 2008 Dec 30; 26(3). PMID: 19112599
The hallmarks of cancer.
D Hanahan, R A Weinberg.
Cell, 2000 Jan 27; 100(1). PMID: 10647931
Highly Cited. Review.
Cancer: Genomic evolution of metastasis.
E Georg Luebeck.
Nature, 2010 Oct 29; 467(7319). PMID: 20981088
Recurrence pattern and prognosis of pancreatic cancer after pancreatic fistula.
Shunji Nagai, Tsutomu Fujii, +9 authors, Akimasa Nakao.
Ann Surg Oncol, 2011 Feb 18; 18(8). PMID: 21327822
Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases.
Julie M Wu, Mary Jo Fackler, +12 authors, Pedram Argani.
Clin Cancer Res, 2008 Apr 03; 14(7). PMID: 18381931    Free PMC article.
Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS).
Alastair M Thompson, Lee B Jordan, +5 authors, Breast Recurrence in Tissues Study Group.
Breast Cancer Res, 2010 Nov 10; 12(6). PMID: 21059212    Free PMC article.
Genes that mediate breast cancer metastasis to the brain.
Paula D Bos, Xiang H-F Zhang, +8 authors, Joan Massagué.
Nature, 2009 May 08; 459(7249). PMID: 19421193    Free PMC article.
Highly Cited.
A multigenic program mediating breast cancer metastasis to bone.
Yibin Kang, Peter M Siegel, +5 authors, Joan Massagué.
Cancer Cell, 2003 Jul 05; 3(6). PMID: 12842083
Highly Cited.
Lack of concordant p53 mutations in some paired primary and metastatic mouse squamous cell carcinomas induced by chemical carcinogenesis.
S Y Zhang, B Bauer, +2 authors, A J Klein-Szanto.
Mol Carcinog, 1995 Feb 01; 12(2). PMID: 7662119
Response of DNA ploidy to chemotherapy in primary and metastatic lesions in human osteosarcomas.
K Kusuzaki, S Hashiguchi, +4 authors, Y Hirasawa.
Cancer Lett, 1999 Jun 23; 138(1-2). PMID: 10378788
The tumor microenvironment and its contribution to tumor evolution toward metastasis.
Girieca Lorusso, Curzio Rüegg.
Histochem Cell Biol, 2008 Nov 07; 130(6). PMID: 18987874
Highly Cited. Review.
Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?
Sunny Y Wong, Richard O Hynes.
Cell Cycle, 2006 Apr 22; 5(8). PMID: 16627996    Free PMC article.
Review.
Identification of genetic disparity between primary and metastatic melanoma in human patients.
Alexander Swoboda, Doris Rasin-Streden, +4 authors, Mario Mikula.
Genes Chromosomes Cancer, 2011 May 18; 50(9). PMID: 21584902
Proliferative characteristics of primary and metastatic human solid tumors by DNA flow cytometry.
O S Frankfurt, W R Greco, +4 authors, Y M Rustum.
Cytometry, 1984 Nov 01; 5(6). PMID: 6518938
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
A Kalikaki, A Koutsopoulos, +5 authors, A Voutsina.
Br J Cancer, 2009 Feb 25; 99(6). PMID: 19238633    Free PMC article.
Smoking and lung cancer: the role of inflammation.
Tonya Walser, Xiaoyan Cui, +5 authors, Steven M Dubinett.
Proc Am Thorac Soc, 2008 Nov 20; 5(8). PMID: 19017734    Free PMC article.
Comparison of CD44 expression in primary tumours and metastases of colorectal cancer.
R Bendardaf, A Algars, +6 authors, S Pyrhönen.
Oncol Rep, 2006 Sep 14; 16(4). PMID: 16969488
Detection of mutations in EGFR in circulating lung-cancer cells.
Shyamala Maheswaran, Lecia V Sequist, +15 authors, Daniel A Haber.
N Engl J Med, 2008 Jul 04; 359(4). PMID: 18596266    Free PMC article.
Highly Cited.
MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors.
Aatur D Singhi, Ashley Cimino-Mathews, +9 authors, Pedram Argani.
Mod Pathol, 2011 Nov 08; 25(3). PMID: 22056952    Free PMC article.
AACR centennial series: the biology of cancer metastasis: historical perspective.
James E Talmadge, Isaiah J Fidler.
Cancer Res, 2010 Jul 09; 70(14). PMID: 20610625    Free PMC article.
Highly Cited. Review.
Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses.
Amy L Lark, Chad A Livasy, +4 authors, William G Cance.
Clin Cancer Res, 2003 Jan 23; 9(1). PMID: 12538472
Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer.
Marc Buyse, Sherene Loi, +18 authors, TRANSBIG Consortium.
J Natl Cancer Inst, 2006 Sep 07; 98(17). PMID: 16954471
Highly Cited.
Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model.
Valerie Montel, To-Yu Huang, +2 authors, David Tarin.
Am J Pathol, 2005 Apr 28; 166(5). PMID: 15855655    Free PMC article.
Immunochemical analysis of the p53 oncoprotein in matched primary and metastatic human tumours.
J Bartkova, J Bartek, +6 authors, D M Barnes.
Eur J Cancer, 1993 Jan 01; 29A(6). PMID: 8484983
A gene-expression signature as a predictor of survival in breast cancer.
Marc J van de Vijver, Yudong D He, +18 authors, René Bernards.
N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681
Highly Cited.
Dynamic heterogeneity and metastasis.
V Ling, A F Chambers, J F Harris, R P Hill.
J Cell Physiol Suppl, 1984 Jan 01; 3. PMID: 6589232
Impact of cirrhosis on the development of experimental hepatic metastases by B16F1 melanoma cells in C57BL/6 mice.
Ke Qi, Hongming Qiu, +4 authors, F William Orr.
Hepatology, 2004 Sep 24; 40(5). PMID: 15382152
O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers.
Pei-Fang Wu, Kuan-Ting Kuo, +11 authors, Ching-Hung Lin.
Lung Cancer, 2009 Sep 11; 68(3). PMID: 19740564
Immune-mediated dormancy: an equilibrium with cancer.
Michele W L Teng, Jeremy B Swann, +2 authors, Mark J Smyth.
J Leukoc Biol, 2008 Jun 03; 84(4). PMID: 18515327
Review.
Epidermal growth factor receptor (EGFR) status in primary colorectal tumors correlates with EGFR expression in related metastatic sites: biological and clinical implications.
A Italiano, M-C Saint-Paul, +5 authors, J-F Michiels.
Ann Oncol, 2005 Jun 28; 16(9). PMID: 15980160
Dynamic heterogeneity: experimental metastasis studies with RIF-1 fibrosarcoma.
B M Korycka, R P Hill.
Clin Exp Metastasis, 1989 Jan 01; 7(1). PMID: 2908825
Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small-cell lung cancer.
C-H Gow, Y-L Chang, +7 authors, J-Y Shih.
Ann Oncol, 2008 Dec 18; 20(4). PMID: 19088172
P53 mutations in primary and metastatic tumors and circulating tumor cells from colorectal carcinoma patients.
Z A Khan, S K Jonas, +5 authors, T G Allen-Mersh.
Clin Cancer Res, 2000 Sep 22; 6(9). PMID: 10999735
Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression.
Andrzej B Popławski, Michał Jankowski, +18 authors, Jan P Dumanski.
Eur J Hum Genet, 2010 Jan 07; 18(5). PMID: 20051991    Free PMC article.
Microarray studies challenge theories of metastasis.
Tracy Webb.
J Natl Cancer Inst, 2003 Mar 06; 95(5). PMID: 12618498
Comparison of nuclear DNA content in primary and metastatic papillary thyroid carcinoma.
M Bäckdahl, K Cohn, +6 authors, A Zetterberg.
Cancer Res, 1985 Jun 01; 45(6). PMID: 3986815
EGFR, c-erbB2 and p53 protein in the primary lesions and paired metastatic regional lymph nodes in breast cancer.
S Tsutsui, S Ohno, +3 authors, Y Hachitanda.
Eur J Surg Oncol, 2002 Jul 09; 28(4). PMID: 12099646
Dissecting the metastatic cascade.
Klaus Pantel, Ruud H Brakenhoff.
Nat Rev Cancer, 2004 Jun 02; 4(6). PMID: 15170447
Highly Cited. Review.
p53 and erbB-2 are not associated in matched cases of primary and metastatic ovarian carcinomas.
Cristina Rodríguez-Burford, David C Chhieng, +5 authors, William E Grizzle.
Dis Markers, 2004 Feb 06; 19(1). PMID: 14757942    Free PMC article.
TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis.
Nele Müller-Hermelink, Heidi Braumüller, +14 authors, Martin Röcken.
Cancer Cell, 2008 Jun 10; 13(6). PMID: 18538734
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors.
Andy J Minn, Yibin Kang, +7 authors, Joan Massagué.
J Clin Invest, 2005 Jan 05; 115(1). PMID: 15630443    Free PMC article.
Highly Cited.
The pathogenesis of cancer metastasis.
G Poste, I J Fidler.
Nature, 1980 Jan 10; 283(5743). PMID: 6985715
Highly Cited. Review.
Telomere length, telomeric proteins and DNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases.
Christophe M Raynaud, Olaf Mercier, +5 authors, Jean-Charles Soria.
Lung Cancer, 2008 Dec 19; 65(2). PMID: 19091442
Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor.
James R Vasselli, Joanna H Shih, +12 authors, W Marston Linehan.
Proc Natl Acad Sci U S A, 2003 Jun 05; 100(12). PMID: 12777628    Free PMC article.
The metastatic niche: adapting the foreign soil.
Bethan Psaila, David Lyden.
Nat Rev Cancer, 2009 Mar 25; 9(4). PMID: 19308068    Free PMC article.
Highly Cited. Review.
Differential gene expression during colon-to-lung metastasis.
Sung-Hyun Kim, So-Jung Choi, +8 authors, Jhingook Kim.
Oncol Rep, 2011 Jan 15; 25(3). PMID: 21234521
Management of distant solitary recurrence in the patient with renal cancer. Contralateral kidney and other sites.
J M Kozlowski.
Urol Clin North Am, 1994 Nov 01; 21(4). PMID: 7974893
Review.
p53 mutations in primary human lung tumors and their metastases.
M B Reichel, H Ohgaki, I Petersen, P Kleihues.
Mol Carcinog, 1994 Feb 01; 9(2). PMID: 8142008
Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
Shinichi Yachida, Siân Jones, +11 authors, Christine A Iacobuzio-Donahue.
Nature, 2010 Oct 29; 467(7319). PMID: 20981102    Free PMC article.
Highly Cited.
A six-gene signature predicting breast cancer lung metastasis.
Thomas Landemaine, Amanda Jackson, +16 authors, Keltouma Driouch.
Cancer Res, 2008 Aug 05; 68(15). PMID: 18676831
Concordance of predictive markers for EGFR inhibitors in primary tumors and metastases in colorectal cancer: a review.
Jara M Baas, Lisanne L Krens, +2 authors, Hans Gelderblom.
Oncologist, 2011 Jul 12; 16(9). PMID: 21742964    Free PMC article.
Review.
Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer.
T Kuukasjärvi, R Karhu, +7 authors, J Isola.
Cancer Res, 1997 Apr 15; 57(8). PMID: 9108466
Highly Cited.
A progression puzzle.
René Bernards, Robert A Weinberg.
Nature, 2002 Aug 23; 418(6900). PMID: 12192390
Highly Cited.
Cancer metastasis: building a framework.
Gaorav P Gupta, Joan Massagué.
Cell, 2006 Nov 18; 127(4). PMID: 17110329
Highly Cited. Review.
Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor.
Siu Tim Cheung, Xin Chen, +5 authors, Sheung Tat Fan.
Cancer Res, 2002 Aug 17; 62(16). PMID: 12183430
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
Howard Y Chang, Julie B Sneddon, +7 authors, Patrick O Brown.
PLoS Biol, 2004 Jan 23; 2(2). PMID: 14737219    Free PMC article.
Highly Cited.
Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis.
Hirotoshi Kobayashi, Kenichi Sugihara, +7 authors, Peter V Danenberg.
Int J Oncol, 2009 Mar 17; 34(4). PMID: 19287974
Deleted in colon cancer protein expression in colorectal cancer metastases: a major predictor of survival in patients with unresectable metastatic disease receiving palliative fluorouracil-based chemotherapy.
Carlo Aschele, Domizia Debernardis, +4 authors, Luigi Gallo.
J Clin Oncol, 2004 Sep 15; 22(18). PMID: 15365072
The sympathetic nervous system induces a metastatic switch in primary breast cancer.
Erica K Sloan, Saul J Priceman, +9 authors, Steven W Cole.
Cancer Res, 2010 Sep 09; 70(18). PMID: 20823155    Free PMC article.
Highly Cited.
Comparison of topoisomerase-IIalpha gene status between primary breast cancer and corresponding distant metastatic sites.
V Durbecq, A Di Leo, +4 authors, D Larsimont.
Breast Cancer Res Treat, 2003 Feb 27; 77(3). PMID: 12602919
Flow cytometric deoxyribonucleic acid analysis of primary and metastatic human renal cell carcinoma.
J L Chin, J E Pontes, O S Frankfurt.
J Urol, 1985 Apr 01; 133(4). PMID: 3981703
Gene expression profiles of primary breast tumors maintained in distant metastases.
Britta Weigelt, Annuska M Glas, +3 authors, Laura J van't Veer.
Proc Natl Acad Sci U S A, 2003 Dec 11; 100(26). PMID: 14665696    Free PMC article.
Highly Cited.
Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell lung cancer.
Hideharu Kimura, Kazuo Kasahara, +4 authors, Kazuto Nishio.
Clin Cancer Res, 2006 Jul 05; 12(13). PMID: 16818687
Highly Cited.
Genetic alterations in primary bladder cancers and their metastases.
R M Hovey, L Chu, +5 authors, F M Waldman.
Cancer Res, 1998 Aug 29; 58(16). PMID: 9721860
p53 gene mutations in primary lung tumors are conserved in brain metastases.
U Schlegel, M R Rosenfeld, +3 authors, H Furneaux.
J Neurooncol, 1992 Oct 01; 14(2). PMID: 1331352
Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses.
Andrea Imperatori, Nicola Rotolo, +6 authors, Daniela Furlan.
BMC Cancer, 2015 Aug 02; 15. PMID: 26231173    Free PMC article.
SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer.
Dong-Ming Wu, Teng Liu, +2 authors, Ying Xu.
Sci Rep, 2017 Aug 05; 7(1). PMID: 28775359    Free PMC article.
Expression and prognostic value of epithelial-to-mesenchymal transition and cancer stem cellmarkersin primary lesions and liver metastases of colorectal cancers.
Cong Li, Ji-Yan Liu, Dan Jiang, Meng Qiu.
Oncol Lett, 2021 May 14; 22(1). PMID: 33981361    Free PMC article.