Journal Article
. 2013 Dec; 2(9):e25801.
doi: 10.4161/onci.25801.

Long peptide-based cancer immunotherapy targeting tumor antigen-specific CD4+ and CD8+ T cells

Yusuke Tomita 1 Yasuharu Nishimura  
Affiliations
  • PMID: 24327937
  •     10 References
  •     6 citations

Abstract

CD4+ T cells promote cytotoxic T lymphocyte (CTL)-mediated anticancer immune responses. We have recently identified ideal tumor-associated antigen (TAA)-derived long peptides (LPs) that elicit not only TAA-specific TH1 response, but also CTLs, through cross-presentation. The LP-specific TH1 cell responses were augmented in cancer patients vaccinated with CTL epitopes. Our findings support the clinical application of LP-based immunotherapy.

Keywords: Type 1 helper T cell; cDNA microarray analysis; cross-presentation; helper T-cell epitope; peptide vaccine; tumor-associated antigen.

Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.
Mark J Dobrzanski.
Front Oncol, 2013 Mar 28; 3. PMID: 23533029    Free PMC article.
Identification of CDCA1-derived long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients.
Yusuke Tomita, Akira Yuno, +15 authors, Yasuharu Nishimura.
Int J Cancer, 2014 Apr 16; 134(2). PMID: 24734272
Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines.
Cornelis J M Melief, Sjoerd H van der Burg.
Nat Rev Cancer, 2008 Apr 18; 8(5). PMID: 18418403
Highly Cited. Review.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Identification of HLA-A2-restricted CTL epitopes of a novel tumour-associated antigen, KIF20A, overexpressed in pancreatic cancer.
K Imai, S Hirata, +11 authors, Y Nishimura.
Br J Cancer, 2010 Dec 24; 104(2). PMID: 21179034    Free PMC article.
Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor.
Yusuke Tomita, Akira Yuno, +15 authors, Yasuharu Nishimura.
Clin Cancer Res, 2013 May 30; 19(16). PMID: 23714729
Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens.
Koji Kono, Hisae Iinuma, +16 authors, Yusuke Nakamura.
J Transl Med, 2012 Jul 11; 10. PMID: 22776426    Free PMC article.
HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL.
Michiko Harao, Shinya Hirata, +16 authors, Yasuharu Nishimura.
Int J Cancer, 2008 Sep 05; 123(11). PMID: 18770861
Identification of a novel tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric, and colorectal cancers.
Katsunori Imai, Shinya Hirata, +11 authors, Yasuharu Nishimura.
Clin Cancer Res, 2008 Oct 18; 14(20). PMID: 18927288
Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination.
Erik H J G Aarntzen, I Jolanda M De Vries, +15 authors, Carl G Figdor.
Cancer Res, 2012 Oct 23; 73(1). PMID: 23087058
Identification of immunogenic LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes and eliciting CD4+ T-cell immunity in patients with malignant disease.
Yusuke Tomita, Akira Yuno, +17 authors, Yasuharu Nishimura.
Oncoimmunology, 2014 Oct 24; 3. PMID: 25340007    Free PMC article.
CIMT 2014: Next waves in cancer immunotherapy--report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany.
Mustafa Diken, Sebastian Boegel, +6 authors, Sebastian Kreiter.
Hum Vaccin Immunother, 2014 Dec 09; 10(10). PMID: 25483671    Free PMC article.
Adoptive cell therapy with CD4+ T helper 1 cells and CD8+ cytotoxic T cells enhances complete rejection of an established tumour, leading to generation of endogenous memory responses to non-targeted tumour epitopes.
Kunyu Li, Braeden Donaldson, +4 authors, Sarah Young.
Clin Transl Immunology, 2017 Nov 09; 6(10). PMID: 29114389    Free PMC article.
Generation of a cancer testis antigen mCherry reporter HCT116 colorectal carcinoma cell line.
Jyoti B Chhetri, Elena Drousioti, +2 authors, Steen K T Ooi.
Heliyon, 2018 Oct 27; 4(10). PMID: 30364636    Free PMC article.
Antimicrobial Peptides: Potential Application in Liver Cancer.
Chunye Zhang, Ming Yang, Aaron C Ericsson.
Front Microbiol, 2019 Jun 25; 10. PMID: 31231341    Free PMC article.
Review.
NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma.
Vijay Kumar Singh, Sebastian Werner, +8 authors, Wilhelm Woessmann.
Oncoimmunology, 2019 Aug 21; 8(9). PMID: 31428523    Free PMC article.