Journal Article
. 2013 Dec;41(1).
doi: 10.1002/jmri.24519.

Correlations between apparent diffusion coefficient values of invasive ductal carcinoma and pathologic factors on diffusion-weighted MRI at 3.0 Tesla

Sung Hee Park 1 Hye-Young Choi  Soo Yeon Hahn  
Affiliations
  • PMID: 24353241
  •     33 citations

Abstract

Purpose: To investigate correlations between apparent diffusion coefficient (ADC) values of invasive ductal carcinoma (IDC) and pathologic factors on diffusion-weighted MRI. We measured the ADC values of IDC of the breast and analyzed correlations between ADC values and factors such as tumor size, axillary lymph node status, histologic grade, estrogen receptor, progesterone receptor, and human epithelial growth factor 2 (HER2) using diffusion-weighted MRI at 3.0 Tesla (T).

Materials And Methods: We examined 110 patients with pathologically confirmed IDC using diffusion-weighted MRI at 3.0T. The ADC values of breast cancer were calculated using two b factors (0 and 1000 s/mm(2)). The relationship between ADC values and tumor size, histologic grade, axillary lymph node status, hormonal receptors, and HER2 were analyzed.

Results: The mean ADC value of IDC (n = 110) was 0.88 ± 0.15 × 10(-2) mm(2)/s. Tumors were subgrouped according to size (<2 cm, 2-5 cm, and ≥5 cm). Multiple comparisons within subgroups according to size showed that the ADC values for the three tumor size groups were significantly different (correlation coefficient = -0.007). The mean apparent diffusion coefficient of HER2-positive IDC was significantly higher than that of HER2-negative invasive ductal carcinoma (correlation coefficient = 0.218).

Conclusion: ADC values of IDC were significantly correlated with tumor size and HER2 status.

Keywords: ADC value; breast cancer; diffusion weighted image; invasive ductal carcinoma; magnetic resonance imaging.

Preoperative axillary staging with 3.0-T breast MRI: clinical value of diffusion imaging and apparent diffusion coefficient.
Suvi Rautiainen, Mervi Könönen, +5 authors, Anna Sutela.
PLoS One, 2015 Mar 31; 10(3). PMID: 25823016    Free PMC article.
Diffusion-Weighted Imaging in 3.0 Tesla Breast MRI: Diagnostic Performance and Tumor Characterization Using Small Subregions vs. Whole Tumor Regions of Interest.
Otso Arponen, Otso Arponent, +9 authors, Ritva Vanninen.
PLoS One, 2015 Oct 13; 10(10). PMID: 26458106    Free PMC article.
Apparent diffusion coefficient value in invasive ductal carcinoma at 3.0 Tesla: is it correlated with prognostic factors?
Inanc Guvenc, Sinan Akay, +4 authors, Mustafa Tasar.
Br J Radiol, 2016 Feb 09; 89(1060). PMID: 26853508    Free PMC article.
Additional Value of Diffusion-Weighted Imaging to Evaluate Prognostic Factors of Breast Cancer: Correlation with the Apparent Diffusion Coefficient.
Eun Kyung Park, Kyu Ran Cho, +3 authors, Jeoung Won Bae.
Iran J Radiol, 2016 Apr 30; 13(1). PMID: 27127582    Free PMC article.
Potential of Diffusion-Weighted Imaging in the Characterization of Malignant, Benign, and Healthy Breast Tissues and Molecular Subtypes of Breast Cancer.
Uma Sharma, Rani G Sah, +5 authors, Naranamangalam R Jagannathan.
Front Oncol, 2016 Jun 01; 6. PMID: 27242965    Free PMC article.
Quantitative apparent diffusion coefficient measurement obtained by 3.0Tesla MRI as a potential noninvasive marker of tumor aggressiveness in breast cancer.
Manuela Durando, Lucas Gennaro, +7 authors, Sunitha B Thakur.
Eur J Radiol, 2016 Aug 10; 85(9). PMID: 27501902    Free PMC article.
Diffusion-weighted breast MRI: Clinical applications and emerging techniques.
Savannah C Partridge, Noam Nissan, +2 authors, Eric E Sigmund.
J Magn Reson Imaging, 2016 Oct 01; 45(2). PMID: 27690173    Free PMC article.
Highly Cited. Review.
Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers.
Ken Yamaguchi, Takahiko Nakazono, +4 authors, Hiroyuki Irie.
Magn Reson Med Sci, 2016 Nov 18; 16(3). PMID: 27853053    Free PMC article.
PET/MR in invasive ductal breast cancer: correlation between imaging markers and histological phenotype.
Onofrio Antonio Catalano, Gary Lloyd Horn, +11 authors, Bruce Robert Rosen.
Br J Cancer, 2017 Feb 17; 116(7). PMID: 28208155    Free PMC article.
Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR.
Yasin Akın, M Ümit Uğurlu, Handan Kaya, Erkin Arıbal.
J Breast Health, 2016 Jan 01; 12(3). PMID: 28331748    Free PMC article.
Heterogeneity of Diffusion-Weighted Imaging in Tumours and the Surrounding Stroma for Prediction of Ki-67 Proliferation Status in Breast Cancer.
Ming Fan, Ting He, +2 authors, Lihua Li.
Sci Rep, 2017 Jun 08; 7(1). PMID: 28588280    Free PMC article.
Apparent diffusion coefficient in estrogen receptor-positive and lymph node-negative invasive breast cancers at 3.0T DW-MRI: A potential predictor for an oncotype Dx test recurrence score.
Sunitha B Thakur, Manuela Durando, +5 authors, Elizabeth A Morris.
J Magn Reson Imaging, 2017 Jun 24; 47(2). PMID: 28640531    Free PMC article.
Diffusion-weighted imaging of suspicious (BI-RADS 4) breast lesions: stratification based on histopathology.
João Ricardo Maltez de Almeida, André Boechat Gomes, +2 authors, Mario de Souza Rocha.
Radiol Bras, 2017 Jul 04; 50(3). PMID: 28670026    Free PMC article.
Multiparametric Magnetic Resonance Imaging of Prostate Cancer Bone Disease: Correlation With Bone Biopsy Histological and Molecular Features.
Raquel Perez-Lopez, Daniel Nava Rodrigues, +5 authors, Nina Tunariu.
Invest Radiol, 2017 Sep 15; 53(2). PMID: 28906339    Free PMC article.
DWI in the Assessment of Breast Lesions.
Savannah C Partridge, Nita Amornsiripanitch.
Top Magn Reson Imaging, 2017 Sep 30; 26(5). PMID: 28961569    Free PMC article.
Background, current role, and potential applications of radiogenomics.
Katja Pinker, Fuki Shitano, +6 authors, Elizabeth A Morris.
J Magn Reson Imaging, 2017 Nov 03; 47(3). PMID: 29095543    Free PMC article.
Highly Cited. Review.
Diffusion weighted MRI and spectroscopy in invasive carcinoma of the breast at 3Tesla. Correlation with dynamic contrast enhancement and pathologic findings.
G Boulogianni, I Chryssogonidis, A Drevelegas.
Hippokratia, 2016 Jul 01; 20(3). PMID: 29097884    Free PMC article.
Is there any relationship between adc values of diffusion-weighted imaging and the histopathological prognostic factors of invasive ductal carcinoma?
Hale Aydin, Bahar Guner, +4 authors, Mehmet Ali Gulcelik.
Br J Radiol, 2018 Jan 05; 91(1084). PMID: 29299933    Free PMC article.
Relationship between functional imaging and immunohistochemical markers and prediction of breast cancer subtype: a PET/MRI study.
Mariarosaria Incoronato, Anna Maria Grimaldi, +9 authors, Marco Salvatore.
Eur J Nucl Med Mol Imaging, 2018 Apr 27; 45(10). PMID: 29696443
Dual-Phase ADC Modelling of Breast Masses in Diffusion-Weighted Imaging: Comparison with Histopathologic Findings.
Gökhan Ertaş, Can Onaygil, Onur Buğdaycı, Erkin Arıbal.
Eur J Breast Health, 2018 May 19; 14(2). PMID: 29774316    Free PMC article.
Correlation between minimum apparent diffusion coefficient values and the histological grade of breast invasive ductal carcinoma.
Suhong Zhao, Weihua Guo, +4 authors, Guangrui Shao.
Oncol Lett, 2018 Jun 01; 15(5). PMID: 29849809    Free PMC article.
Imaging and the completion of the omics paradigm in breast cancer.
D Leithner, J V Horvat, +5 authors, K Pinker.
Radiologe, 2018 Jun 28; 58(Suppl 1). PMID: 29947931    Free PMC article.
Review.
Diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping as a quantitative imaging biomarker for prediction of immunohistochemical receptor status, proliferation rate, and molecular subtypes of breast cancer.
Joao V Horvat, Blanca Bernard-Davila, +11 authors, Katja Pinker.
J Magn Reson Imaging, 2019 Feb 28; 50(3). PMID: 30811717    Free PMC article.
Correlation between apparent diffusion coefficient values in breast magnetic resonance imaging and prognostic factors of breast invasive ductal carcinoma.
Ricardo Moutinho-Guilherme, Janeth Hercilia Oyola, +4 authors, Vicente Martínez de Vega.
Porto Biomed J, 2018 Aug 03; 4(1). PMID: 31595254    Free PMC article.
Can apparent diffusion coefficient (ADC) distinguish breast cancer from benign breast findings? A meta-analysis based on 13 847 lesions.
Alexey Surov, Hans Jonas Meyer, Andreas Wienke.
BMC Cancer, 2019 Oct 17; 19(1). PMID: 31615463    Free PMC article.
Histogram Analysis and Visual Heterogeneity of Diffusion-Weighted Imaging with Apparent Diffusion Coefficient Mapping in the Prediction of Molecular Subtypes of Invasive Breast Cancers.
Joao V Horvat, Aditi Iyer, +9 authors, Sunitha B Thakur.
Contrast Media Mol Imaging, 2019 Dec 11; 2019. PMID: 31819738    Free PMC article.
Combining molecular and imaging metrics in cancer: radiogenomics.
Roberto Lo Gullo, Isaac Daimiel, Elizabeth A Morris, Katja Pinker.
Insights Imaging, 2020 Jan 05; 11(1). PMID: 31901171    Free PMC article.
Review.
Invasive ductal breast cancer: preoperative predict Ki-67 index based on radiomics of ADC maps.
Yu Zhang, Yifeng Zhu, +5 authors, Shaowu Wang.
Radiol Med, 2019 Nov 07; 125(2). PMID: 31696388
Differentiation of Breast Lesions and Distinguishing Their Histological Subtypes Using Diffusion-Weighted Imaging and ADC Values.
Jelena Maric, Jasmina Boban, +3 authors, Dragana Bogdanovic-Stojanovic.
Front Oncol, 2020 Apr 02; 10. PMID: 32232007    Free PMC article.
Diffusion-weighted imaging of the breast: current status as an imaging biomarker and future role.
Julia Camps-Herrero.
BJR Open, 2019 Mar 08; 1(1). PMID: 33178933    Free PMC article.
Review.
Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 Tesla.
Fei Liu, Mei Wang, Haige Li.
World J Surg Oncol, 2018 Dec 24; 16(1). PMID: 30577820    Free PMC article.
Quantitative parameters of MRI and 18F-FDG PET/CT in the prediction of breast cancer prognosis and molecular type: an original study.
Pavel Borisovich Gelezhe, Ivan Andreevich Blokhin, Damir Ildarovich Marapov, Sergey Pavlovich Morozov.
Am J Nucl Med Mol Imaging, 2020 Dec 18; 10(6). PMID: 33329930    Free PMC article.
[Multimodal, multiparametric and genetic breast imaging].
Roberto LoGullo, Joao Horvat, Jeffrey Reiner, Katja Pinker.
Radiologe, 2021 Jan 20; 61(2). PMID: 33464404
Review.