Journal Article
. 2014 Jan; 124(2):687-95.
doi: 10.1172/JCI67313.

Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice

Liufu Deng  Hua Liang  Byron Burnette  Michael Beckett  Thomas Darga  Ralph R Weichselbaum  Yang-Xin Fu  
  • PMID: 24382348
  •     43 References
  •     719 citations


High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-specific immunity, which enhances tumor control both locally and distantly. Unfortunately, local relapses often occur following IR treatment, indicating that IR-induced responses are inadequate to maintain antitumor immunity. Therapeutic blockade of the T cell negative regulator programmed death-ligand 1 (PD-L1, also called B7-H1) can enhance T cell effector function when PD-L1 is expressed in chronically inflamed tissues and tumors. Here, we demonstrate that PD-L1 was upregulated in the tumor microenvironment after IR. Administration of anti-PD-L1 enhanced the efficacy of IR through a cytotoxic T cell-dependent mechanism. Concomitant with IR-mediated tumor regression, we observed that IR and anti-PD-L1 synergistically reduced the local accumulation of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), which suppress T cells and alter the tumor immune microenvironment. Furthermore, activation of cytotoxic T cells with combination therapy mediated the reduction of MDSCs in tumors through the cytotoxic actions of TNF. Our data provide evidence for a close interaction between IR, T cells, and the PD-L1/PD-1 axis and establish a basis for the rational design of combination therapy with immune modulators and radiotherapy.

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PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor.
Liangrong Shi, Lujun Chen, +10 authors, Jingting Jiang.
Clin Cancer Res, 2016 Mar 05; 22(5). PMID: 26933175    Free PMC article.
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.
Weiping Zou, Jedd D Wolchok, Lieping Chen.
Sci Transl Med, 2016 Mar 05; 8(328). PMID: 26936508    Free PMC article.
Highly Cited. Review.
A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II).
Shankar Siva, Tomas Kron, +13 authors, David Ball.
BMC Cancer, 2016 Mar 06; 16. PMID: 26944262    Free PMC article.
Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice.
Lena Seifert, Gregor Werba, +16 authors, George Miller.
Gastroenterology, 2016 Mar 08; 150(7). PMID: 26946344    Free PMC article.
Highly Cited.
NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression.
Priscilla S Simon, Kankana Bardhan, +9 authors, Kebin Liu.
Oncotarget, 2016 Mar 26; 7(17). PMID: 27014915    Free PMC article.
Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity.
Yongkui Li, Min Fang, +9 authors, Lin Wang.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057439    Free PMC article.
Immunotherapy for cancer in the central nervous system: Current and future directions.
David C Binder, Andrew A Davis, Derek A Wainwright.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057463    Free PMC article.
Highly Cited. Review.
Feasibility study of DCs/CIKs combined with thoracic radiotherapy for patients with locally advanced or metastatic non-small-cell lung cancer.
Luping Zhang, Yanmei Xu, +5 authors, Jianguo Sun.
Radiat Oncol, 2016 Apr 22; 11. PMID: 27097970    Free PMC article.
Emerging therapeutic targets in esophageal adenocarcinoma.
Puja Gaur, Clayton R Hunt, Tej K Pandita.
Oncotarget, 2016 Apr 23; 7(30). PMID: 27102294    Free PMC article.
Radiation therapy and the abscopal effect: a concept comes of age.
John Ng, Tong Dai.
Ann Transl Med, 2016 Apr 30; 4(6). PMID: 27127771    Free PMC article.
Tumor-intrinsic oncogene pathways mediating immune avoidance.
Stefani Spranger, Thomas F Gajewski.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141343    Free PMC article.
Highly Cited. Review.
miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint.
Shaohua Xu, Zhen Tao, +18 authors, Ke Chen.
Nat Commun, 2016 May 06; 7. PMID: 27147225    Free PMC article.
Highly Cited.
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.
Paula Kroon, Jules Gadiot, +7 authors, Inge Verbrugge.
Cancer Immunol Immunother, 2016 May 11; 65(6). PMID: 27160390    Free PMC article.
Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma.
Georgia J B McCaughan, Michael J Fulham, +5 authors, Vivek A Bhadri.
J Hematol Oncol, 2016 Jun 05; 9(1). PMID: 27259563    Free PMC article.
Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy.
Kristina H Young, Jason R Baird, +9 authors, Marka R Crittenden.
PLoS One, 2016 Jun 10; 11(6). PMID: 27281029    Free PMC article.
Highly Cited.
Neutrophils in cancer: neutral no more.
Seth B Coffelt, Max D Wellenstein, Karin E de Visser.
Nat Rev Cancer, 2016 Jun 11; 16(7). PMID: 27282249
Highly Cited. Review.
Checkpoint Inhibitors in Head and Neck Cancer: Rationale, Clinical Activity, and Potential Biomarkers.
Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri.
Curr Treat Options Oncol, 2016 Jun 18; 17(8). PMID: 27315066
Emerging targets for radioprotection and radiosensitization in radiotherapy.
Sumit Kumar, Rajnish Kumar Singh, Ramovatar Meena.
Tumour Biol, 2016 Oct 27; 37(9). PMID: 27318945
The role of myeloid cells in cancer therapies.
Camilla Engblom, Christina Pfirschke, Mikael J Pittet.
Nat Rev Cancer, 2016 Jun 25; 16(7). PMID: 27339708
Highly Cited. Review.
Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation.
Lisa Deloch, Anja Derer, +3 authors, Udo S Gaipl.
Front Oncol, 2016 Jul 06; 6. PMID: 27379203    Free PMC article.
Highly Cited. Review.
Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer.
Vishwajith Sridharan, Danielle N Margalit, +10 authors, Jonathan D Schoenfeld.
Br J Cancer, 2016 Jul 06; 115(2). PMID: 27380136    Free PMC article.
Mechanisms of immune evasion and current status of checkpoint inhibitors in non-small cell lung cancer.
Angel Qin, David G Coffey, Edus H Warren, Nithya Ramnath.
Cancer Med, 2016 Jul 16; 5(9). PMID: 27416962    Free PMC article.
Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors.
Eric D Brooks, Jonathan E Schoenhals, +4 authors, James W Welsh.
Cancer J, 2016 Jul 22; 22(4). PMID: 27441745    Free PMC article.
Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era.
Everett J Moding, Yvonne M Mowery, David G Kirsch.
Cancer J, 2016 Jul 22; 22(4). PMID: 27441746    Free PMC article.
Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy.
Ying-Chieh Yang, Chi-Shiun Chiang.
Front Oncol, 2016 Jul 23; 6. PMID: 27446811    Free PMC article.
Immuno-oncology combinations: raising the tail of the survival curve.
Samuel J Harris, Jessica Brown, Juanita Lopez, Timothy A Yap.
Cancer Biol Med, 2016 Jul 28; 13(2). PMID: 27458526    Free PMC article.
Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer.
Jessica Nakhlé, Valérie Pierron, +4 authors, Fabien Schmidlin.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471612    Free PMC article.
The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment.
Sara I Pai, Dan P Zandberg, Scott E Strome.
Oral Oncol, 2016 Aug 10; 61. PMID: 27503244    Free PMC article.
PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?
Claud Grigg, Naiyer A Rizvi.
J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532023    Free PMC article.
Highly Cited. Review.
Telltale tumor infiltrating lymphocytes (TIL) in oral, head & neck cancer.
Yu Lei, Yuying Xie, +4 authors, Gregory T Wolf.
Oral Oncol, 2016 Aug 25; 61. PMID: 27553942    Free PMC article.
Stereotactic ablative radiotherapy and immunotherapy combinations: turning the future into systemic therapy?
Richard C Walshaw, Jamie Honeychurch, Tim M Illidge.
Br J Radiol, 2016 Aug 25; 89(1066). PMID: 27556933    Free PMC article.
PD-L1 expression in human cancers and its association with clinical outcomes.
Xin Wang, Feifei Teng, Li Kong, Jinming Yu.
Onco Targets Ther, 2016 Aug 31; 9. PMID: 27574444    Free PMC article.
Highly Cited. Review.
Immune checkpoint inhibitors: the new frontier in non-small-cell lung cancer treatment.
Hazem El-Osta, Kamran Shahid, Glenn M Mills, Prakash Peddi.
Onco Targets Ther, 2016 Aug 31; 9. PMID: 27574451    Free PMC article.
The influence of postoperative lymph node radiation therapy on overall survival of patients with stage III melanoma, a National Cancer Database analysis.
Hasan H Danish, Kirtesh R Patel, +7 authors, Mohammad K Khan.
Melanoma Res, 2016 Oct 26; 26(6). PMID: 27575390    Free PMC article.
Effects of combined sunitinib and extracranial stereotactic radiotherapy on bone marrow hematopoiesis.
Johnny Kao, Jonathan Timmins, Junko Ozao-Choy, Stuart Packer.
Oncol Lett, 2016 Sep 08; 12(3). PMID: 27602153    Free PMC article.
Current clinical trials testing the combination of immunotherapy with radiotherapy.
Josephine Kang, Sandra Demaria, Silvia Formenti.
J Immunother Cancer, 2016 Sep 24; 4. PMID: 27660705    Free PMC article.
Highly Cited.
Radiotherapy to Control Limited Melanoma Progression Following Ipilimumab.
Lauren M Kropp, Jennifer F De Los Santos, Svetlana B McKee, Robert M Conry.
J Immunother, 2016 Sep 24; 39(9). PMID: 27662339    Free PMC article.
Emerging roles of p53 and other tumour-suppressor genes in immune regulation.
César Muñoz-Fontela, Anna Mandinova, Stuart A Aaronson, Sam W Lee.
Nat Rev Immunol, 2016 Nov 01; 16(12). PMID: 27667712    Free PMC article.
Highly Cited. Review.
Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer.
Grit S Herter-Sprie, Shohei Koyama, +18 authors, Kwok-Kin Wong.
JCI Insight, 2016 Oct 05; 1(9). PMID: 27699275    Free PMC article.
Role of multimodality therapy in cIIIA-N2 non-small cell lung cancer: perspective.
Hidehito Horinouchi.
Jpn J Clin Oncol, 2016 Oct 06; 46(12). PMID: 27702837    Free PMC article.
Current Immunotherapies for Sarcoma: Clinical Trials and Rationale.
Demytra Mitsis, Valerie Francescutti, Joseph Skitzki.
Sarcoma, 2016 Oct 06; 2016. PMID: 27703409    Free PMC article.
Checkpoint inhibitors and radiation treatment in Hodgkin's lymphoma : New study concepts of the German Hodgkin Study Group.
C Baues, R Semrau, +4 authors, S Marnitz.
Strahlenther Onkol, 2016 Oct 06; 193(2). PMID: 27704149
The promise of PD-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. PD-L1.
Zhaohui Jin, Harry H Yoon.
J Gastrointest Oncol, 2016 Oct 18; 7(5). PMID: 27747091    Free PMC article.
Trial Watch: Immunotherapy plus radiation therapy for oncological indications.
Erika Vacchelli, Norma Bloy, +13 authors, Lorenzo Galluzzi.
Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757313    Free PMC article.
Correlation between anti-PD-L1 tumor concentrations and tumor-specific and nonspecific biomarkers in a melanoma mouse model.
Ana M Contreras-Sandoval, María Merino, +3 authors, María J Garrido.
Oncotarget, 2016 Oct 21; 7(47). PMID: 27764774    Free PMC article.
Radiotherapy: Changing the Game in Immunotherapy.
Sandra Demaria, C Norman Coleman, Silvia C Formenti.
Trends Cancer, 2016 Oct 25; 2(6). PMID: 27774519    Free PMC article.
Highly Cited. Review.
High-dose irradiation in combination with toll-like receptor 9 agonist CpG oligodeoxynucleotide 7909 downregulates PD-L1 expression via the NF-κB signaling pathway in non-small cell lung cancer cells.
Xue Chen, Qi Zhang, +4 authors, Tiankui Qiao.
Onco Targets Ther, 2016 Nov 02; 9. PMID: 27799798    Free PMC article.
Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy.
Xiaohong Wang, Jonathan E Schoenhals, +18 authors, James W Welsh.
Cancer Res, 2016 Nov 09; 77(4). PMID: 27821490    Free PMC article.
Highly Cited.
Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model.
Gwendolyn J McGinnis, David Friedman, +4 authors, Jacob Raber.
Oncotarget, 2016 Nov 29; 8(6). PMID: 27893434    Free PMC article.
PD1/PD-L1 inhibition as a potential radiosensitizer in head and neck squamous cell carcinoma: a case report.
Misako Nagasaka, Mark Zaki, +4 authors, Ammar Sukari.
J Immunother Cancer, 2016 Nov 30; 4. PMID: 27895920    Free PMC article.
Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting.
Julie E Bauman, Ezra Cohen, +17 authors, Shakun Malik.
Cancer, 2016 Dec 03; 123(7). PMID: 27906454    Free PMC article.
TLR3-Induced Maturation of Murine Dendritic Cells Regulates CTL Responses by Modulating PD-L1 Trafficking.
Aditi Varthaman, Hélène D Moreau, Mathieu Maurin, Philippe Benaroch.
PLoS One, 2016 Dec 03; 11(12). PMID: 27911948    Free PMC article.
Treatment Design and Rationale for a Randomized Trial of Cisplatin and Etoposide Plus Thoracic Radiotherapy Followed by Nivolumab or Placebo for Locally Advanced Non-Small-Cell Lung Cancer (RTOG 3505).
David E Gerber, James J Urbanic, +7 authors, Jeffrey D Bradley.
Clin Lung Cancer, 2016 Dec 08; 18(3). PMID: 27923550    Free PMC article.
PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.
Abul Azad, Su Yin Lim, +9 authors, Emmanouil Fokas.
EMBO Mol Med, 2016 Dec 10; 9(2). PMID: 27932443    Free PMC article.
Highly Cited.
Immuno-Oncology: The Third Paradigm in Early Drug Development.
Juan Martin-Liberal, Cinta Hierro, Maria Ochoa de Olza, Jordi Rodon.
Target Oncol, 2016 Dec 21; 12(2). PMID: 27995439
MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype.
Niamh Lynam-Lennon, Susan Heavey, +8 authors, Stephen G Maher.
Oncotarget, 2016 Dec 22; 8(7). PMID: 28002789    Free PMC article.
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Todd A Aguilera, Marjan Rafat, +12 authors, Amato J Giaccia.
Nat Commun, 2016 Dec 23; 7. PMID: 28008921    Free PMC article.
Highly Cited.
The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications.
Michael Spiotto, Yang-Xin Fu, Ralph R Weichselbaum.
Sci Immunol, 2016 Dec 27; 1(3). PMID: 28018989    Free PMC article.
Update on immune checkpoint inhibitors in gynecological cancers.
Valerie Heong, Natalie Ngoi, David Shao Peng Tan.
J Gynecol Oncol, 2016 Dec 29; 28(2). PMID: 28028993    Free PMC article.
Radiotherapy and immune checkpoint blockades: a snapshot in 2016.
Taeryool Koo, In Ah Kim.
Radiat Oncol J, 2016 Dec 30; 34(4). PMID: 28030901    Free PMC article.
Pneumonitis in cancer patients receiving anti-PD-1 and radiotherapies: Three case reports.
Chieh-Sheng Lu, Jin-Hwang Liu.
Medicine (Baltimore), 2017 Jan 11; 96(1). PMID: 28072716    Free PMC article.
Radiotherapy and immunotherapy: a beneficial liaison?
Ralph R Weichselbaum, Hua Liang, Liufu Deng, Yang-Xin Fu.
Nat Rev Clin Oncol, 2017 Jan 18; 14(6). PMID: 28094262
Highly Cited. Review.
New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone.
Siwen Hu-Lieskovan, Antoni Ribas.
Cancer J, 2017 Jan 24; 23(1). PMID: 28114250    Free PMC article.
Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen.
Gilda G Hillman, Lyndsey A Reich, +7 authors, Philippe Slos.
J Immunother Cancer, 2017 Jan 25; 5. PMID: 28116088    Free PMC article.
A phase II trial of stereotactic body radiotherapy with concurrent anti-PD1 treatment in metastatic melanoma: evaluation of clinical and immunologic response.
Katrien De Wolf, Vibeke Kruse, +5 authors, Piet Ost.
J Transl Med, 2017 Feb 01; 15(1). PMID: 28137295    Free PMC article.
Myeloid-derived suppressor cells mediate tolerance induction in autoimmune disease.
Anja Wegner, Johan Verhagen, David C Wraith.
Immunology, 2017 Feb 01; 151(1). PMID: 28140447    Free PMC article.
Metastatic small cell neuroendocrine carcinoma of the cervix treated with the PD-1 inhibitor, nivolumab: a case report.
Sarah E Paraghamian, Teresa C Longoria, Ramez N Eskander.
Gynecol Oncol Res Pract, 2017 Feb 09; 4. PMID: 28174665    Free PMC article.
Irradiation enhances dendritic cell potential antitumor activity by inducing tumor cell expressing TNF-α.
Lijia Chang, Zhengzheng Zhang, +3 authors, Shuxia Song.
Med Oncol, 2017 Feb 15; 34(3). PMID: 28194716
Plasma levels of soluble programmed death ligand-1 may be associated with overall survival in nonsmall cell lung cancer patients receiving thoracic radiotherapy.
Jing Zhao, Peng Zhang, +4 authors, Guangyuan Hu.
Medicine (Baltimore), 2017 Feb 17; 96(7). PMID: 28207525    Free PMC article.
A meta-analysis of the abscopal effect in preclinical models: Is the biologically effective dose a relevant physical trigger?
Raffaella Marconi, Silvia Strolin, Gianluca Bossi, Lidia Strigari.
PLoS One, 2017 Feb 22; 12(2). PMID: 28222111    Free PMC article.
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.
Eszter Lázár-Molnár, Lisa Scandiuzzi, +7 authors, Steven C Almo.
EBioMedicine, 2017 Feb 25; 17. PMID: 28233730    Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors.
Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim.
Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545    Free PMC article.
Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase.
Todd A Aguilera, Amato J Giaccia.
Clin Cancer Res, 2017 Mar 16; 23(12). PMID: 28289089    Free PMC article.
Immunotherapy for Esophageal Squamous Cell Carcinoma.
Takashi Kojima, Toshihiko Doi.
Curr Oncol Rep, 2017 Apr 01; 19(5). PMID: 28361224    Free PMC article.
The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.
Michele Cioffi, Sara M Trabulo, +15 authors, Christopher Heeschen.
Oncotarget, 2017 Apr 21; 8(13). PMID: 28423491    Free PMC article.
Following the Preclinical Data: Leveraging the Abscopal Effect More Efficaciously.
Wilfred Ngwa, Zi Ouyang.
Front Oncol, 2017 Apr 28; 7. PMID: 28447024    Free PMC article.
Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model.
Kyoung-Jin Kim, Ji-Hye Kim, +3 authors, Jinsil Seong.
Oncotarget, 2017 May 04; 8(25). PMID: 28465485    Free PMC article.
Integrative Analysis Identifies a Novel AXL-PI3 Kinase-PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer.
Heath D Skinner, Uma Giri, +15 authors, John V Heymach.
Clin Cancer Res, 2017 May 10; 23(11). PMID: 28476872    Free PMC article.
Immunotherapy for Head and Neck Squamous Cell Carcinoma: A Review of Current and Emerging Therapeutic Options.
Jessica M Moskovitz, Jennifer Moy, Tanguy Y Seiwert, Robert L Ferris.
Oncologist, 2017 May 17; 22(6). PMID: 28507203    Free PMC article.
Harnessing the potential synergy of combining radiation therapy and immunotherapy for thoracic malignancies.
Charles B Simone, Abigail T Berman, Salma K Jabbour.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529893    Free PMC article.
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer.
Salma K Jabbour, Abigail T Berman, Charles B Simone.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529894    Free PMC article.
Clinical experiences of combining immunotherapy and radiation therapy in non-small cell lung cancer: lessons from melanoma.
Anusha Kalbasi, Ramesh Rengan.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529899    Free PMC article.
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer.
Neil K Taunk, Andreas Rimner, +3 authors, Jamie Chaft.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529900    Free PMC article.
Immunotherapy and radiation therapy for malignant pleural mesothelioma.
Evan W Alley, Sharyn I Katz, Keith A Cengel, Charles B Simone.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529903    Free PMC article.
Combining radiotherapy with immunotherapy: the past, the present and the future.
Evert J Van Limbergen, Dirk K De Ruysscher, +8 authors, Philippe Lambin.
Br J Radiol, 2017 May 26; 90(1076). PMID: 28541096    Free PMC article.
Immunotherapy and radiation in glioblastoma.
Solmaz Sahebjam, Andrew Sharabi, +2 authors, Prakash Chinnaiyan.
J Neurooncol, 2017 Jun 02; 134(3). PMID: 28567588
Immunotherapy in head and neck cancer: aiming at EXTREME precision.
Petr Szturz, Jan B Vermorken.
BMC Med, 2017 Jun 03; 15(1). PMID: 28571578    Free PMC article.
Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness.
Qiuji Wu, Awatef Allouch, +4 authors, Jean-Luc Perfettini.
Front Immunol, 2017 Jun 13; 8. PMID: 28603525    Free PMC article.
Intratumoral infection by CMV may change the tumor environment by directly interacting with tumor-associated macrophages to promote cancer immunity.
Dan A Erkes, Nicole A Wilski, Christopher M Snyder.
Hum Vaccin Immunother, 2017 Jun 13; 13(8). PMID: 28604162    Free PMC article.
Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies.
Jeong A Park, Nai-Kong V Cheung.
Cancer Treat Rev, 2017 Jun 18; 58. PMID: 28622628    Free PMC article.
DNA Damage and Repair Biomarkers of Immunotherapy Response.
Kent W Mouw, Michael S Goldberg, Panagiotis A Konstantinopoulos, Alan D D'Andrea.
Cancer Discov, 2017 Jun 21; 7(7). PMID: 28630051    Free PMC article.
Highly Cited. Review.
Programmed death-1 pathway blockade produces a synergistic antitumor effect: combined application in ovarian cancer.
Xinxin Zhu, Jinghe Lang.
J Gynecol Oncol, 2017 Jun 29; 28(5). PMID: 28657225    Free PMC article.
A phase I/II trial of fixed-dose stereotactic body radiotherapy with sequential or concurrent pembrolizumab in metastatic urothelial carcinoma: evaluation of safety and clinical and immunologic response.
Nora Sundahl, Katrien De Wolf, +11 authors, Piet Ost.
J Transl Med, 2017 Jul 01; 15(1). PMID: 28662677    Free PMC article.
Dose-dependent enhancement of T-lymphocyte priming and CTL lysis following ionizing radiation in an engineered model of oral cancer.
Megan Morisada, Ellen C Moore, +5 authors, Clint T Allen.
Oral Oncol, 2017 Jul 10; 71. PMID: 28688697    Free PMC article.
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Qianghu Wang, Baoli Hu, +31 authors, Roel G W Verhaak.
Cancer Cell, 2017 Jul 12; 32(1). PMID: 28697342    Free PMC article.
Highly Cited.
A perspective on the impact of radiation therapy on the immune rheostat.
William H McBride, Ekambaram Ganapathy, +3 authors, Dörthe Schaue.
Br J Radiol, 2017 Jul 15; 90(1078). PMID: 28707537    Free PMC article.
Inhibitors of the PD-1/PD-L1 axis for the treatment of head and neck cancer: current status and future perspectives.
Xiongwen Ran, Kai Yang.
Drug Des Devel Ther, 2017 Jul 20; 11. PMID: 28721019    Free PMC article.
Tumor cell PD-L1 predicts poor local control for rectal cancer patients following neoadjuvant radiotherapy.
Lingdong Shao, Qingqin Peng, +5 authors, Junxin Wu.
Cancer Manag Res, 2017 Jul 20; 9. PMID: 28721097    Free PMC article.
PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy.
Junyu Long, Jianzhen Lin, +7 authors, Haitao Zhao.
J Hematol Oncol, 2017 Aug 05; 10(1). PMID: 28774337    Free PMC article.
Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma.
Russell Maxwell, Christopher M Jackson, Michael Lim.
Curr Treat Options Oncol, 2017 Aug 09; 18(8). PMID: 28785997
Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases-Implications for Intraoperative Radiotherapy after Resection.
Carsten Herskind, Frederik Wenz, Frank A Giordano.
Front Oncol, 2017 Aug 10; 7. PMID: 28791250    Free PMC article.
Preclinical immunoPET/CT imaging using Zr-89-labeled anti-PD-L1 monoclonal antibody for assessing radiation-induced PD-L1 upregulation in head and neck cancer and melanoma.
Masahiro Kikuchi, David A Clump, +6 authors, Robert L Ferris.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811971    Free PMC article.
Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors.
Carmelo Tibaldi, Alice Lunghi, Editta Baldini.
World J Clin Oncol, 2017 Aug 30; 8(4). PMID: 28848698    Free PMC article.
Stimulating Innate Immunity to Enhance Radiation Therapy-Induced Tumor Control.
Jason R Baird, Arta M Monjazeb, +4 authors, Michael J Gough.
Int J Radiat Oncol Biol Phys, 2017 Sep 06; 99(2). PMID: 28871985    Free PMC article.
PD-1 mRNA expression in peripheral blood cells and its modulation characteristics in cancer patients.
Wei Wang, Ge Shen, +12 authors, Guangxian Liu.
Oncotarget, 2017 Sep 09; 8(31). PMID: 28881603    Free PMC article.
PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer.
Benjamin A Kansy, Fernando Concha-Benavente, +13 authors, Robert L Ferris.
Cancer Res, 2017 Sep 15; 77(22). PMID: 28904066    Free PMC article.
Highly Cited.
Macrophage biology plays a central role during ionizing radiation-elicited tumor response.
Qiuji Wu, Awatef Allouch, +3 authors, Jean-Luc Perfettini.
Biomed J, 2017 Sep 19; 40(4). PMID: 28918908    Free PMC article.
Nanomaterials for cancer immunotherapy.
Wantong Song, Sara N Musetti, Leaf Huang.
Biomaterials, 2017 Sep 30; 148. PMID: 28961532    Free PMC article.
Improving radiotherapy in cancer treatment: Promises and challenges.
Helen H W Chen, Macus Tien Kuo.
Oncotarget, 2017 Oct 06; 8(37). PMID: 28977985    Free PMC article.
A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma.
Paolo D'Arrigo, Michele Russo, +10 authors, Simona Romano.
Oncotarget, 2017 Oct 06; 8(40). PMID: 28978117    Free PMC article.
Immune recognition of irradiated cancer cells.
Erik Wennerberg, Claire Vanpouille-Box, +3 authors, Lorenzo Galluzzi.
Immunol Rev, 2017 Oct 14; 280(1). PMID: 29027232    Free PMC article.
The anti-PD-1 era - an opportunity to enhance radiotherapy for patients with bladder cancer.
Richard C Walshaw, Jamie Honeychurch, Timothy M Illidge, Ananya Choudhury.
Nat Rev Urol, 2017 Nov 02; 15(4). PMID: 29089607
Pembrolizumab for treatment of advanced gastric and gastroesophageal junction adenocarcinoma.
Smita S Joshi, Steven B Maron, Daniel V Catenacci.
Future Oncol, 2017 Nov 03; 14(5). PMID: 29094609    Free PMC article.
Radiotherapy prolongs the survival of advanced non-small-cell lung cancer patients undergone to an immune-modulating treatment with dose-fractioned cisplatin and metronomic etoposide and bevacizumab (mPEBev).
Pierpaolo Pastina, Valerio Nardone, +15 authors, Pierpaolo Correale.
Oncotarget, 2017 Nov 05; 8(44). PMID: 29100279    Free PMC article.
Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway.
Ming Jing Shen, Li Jun Xu, +5 authors, Yuhchyau Chen.
Oncotarget, 2017 Nov 09; 8(46). PMID: 29113321    Free PMC article.
Abscopal effect in recurrent colorectal cancer treated with carbon-ion radiation therapy: 2 case reports.
Daniel K Ebner, Tadashi Kamada, Shigeru Yamada.
Adv Radiat Oncol, 2017 Nov 09; 2(3). PMID: 29114600    Free PMC article.
Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade.
Haoran Zha, Xiao Han, +5 authors, Bo Zhu.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123963    Free PMC article.
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma.
Ayman Oweida, Shelby Lennon, +11 authors, Sana D Karam.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123967    Free PMC article.
Imaging PD-L1 Expression with ImmunoPET.
Charles Truillet, Hsueh Ling J Oh, +19 authors, Michael J Evans.
Bioconjug Chem, 2017 Nov 11; 29(1). PMID: 29125731    Free PMC article.
Cure in Advanced Renal Cell Cancer: Is It an Achievable Goal?
Dhanusha Sabanathan, John J Park, +3 authors, Howard Gurney.
Oncologist, 2017 Nov 18; 22(12). PMID: 29146617    Free PMC article.
Radiation therapy-induced metastasis: radiobiology and clinical implications.
Benjamin J Blyth, Aidan J Cole, Michael P MacManus, Olga A Martin.
Clin Exp Metastasis, 2017 Nov 22; 35(4). PMID: 29159430
Decreased Survival After Combining Thoracic Irradiation and an Anti-PD-1 Antibody Correlated With Increased T-cell Infiltration Into Cardiac and Lung Tissues.
Carey J Myers, Bo Lu.
Int J Radiat Oncol Biol Phys, 2017 Nov 23; 99(5). PMID: 29165283    Free PMC article.
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells.
Hiro Sato, Atsuko Niimi, +14 authors, Atsushi Shibata.
Nat Commun, 2017 Nov 25; 8(1). PMID: 29170499    Free PMC article.
Highly Cited.
Therapeutic Implications of the Genetic Landscape of Head and Neck Cancer.
Janice Cho, Daniel E Johnson, Jennifer R Grandis.
Semin Radiat Oncol, 2017 Nov 28; 28(1). PMID: 29173752    Free PMC article.
Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers.
Christina H Son, Gini F Fleming, John W Moroney.
Cancer Manag Res, 2017 Dec 01; 9. PMID: 29184441    Free PMC article.
Future cancer research priorities in the USA: a Lancet Oncology Commission.
Elizabeth M Jaffee, Chi Van Dang, +51 authors, Alfred Yung.
Lancet Oncol, 2017 Dec 07; 18(11). PMID: 29208398    Free PMC article.
Detection of programmed death ligand 1 protein and CD8+ lymphocyte infiltration in plurihormonal pituitary adenomas: A case report and review of the literatures.
Pengfei Wang, Tingjian Wang, +3 authors, Changxiang Yan.
Medicine (Baltimore), 2017 Dec 17; 96(49). PMID: 29245312    Free PMC article.
Radiation enhanced the local and distant anti-tumor efficacy in dual immune checkpoint blockade therapy in osteosarcoma.
Yutaka Takahashi, Tomohiro Yasui, +7 authors, Kazuhiko Ogawa.
PLoS One, 2017 Dec 19; 12(12). PMID: 29253865    Free PMC article.
Emerging biomarkers for the combination of radiotherapy and immune checkpoint blockers.
Claire Lhuillier, Claire Vanpouille-Box, +2 authors, Sandra Demaria.
Semin Cancer Biol, 2017 Dec 21; 52(Pt 2). PMID: 29258856    Free PMC article.
Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.
Mirjana Efremova, Dietmar Rieder, +8 authors, Zlatko Trajanoski.
Nat Commun, 2018 Jan 04; 9(1). PMID: 29296022    Free PMC article.
Highly Cited.
Inhibition of PI4K IIIα radiosensitizes in human tumor xenograft and immune-competent syngeneic murine tumor model.
Younghee Park, Ji Min Park, +2 authors, In Ah Kim.
Oncotarget, 2018 Jan 05; 8(66). PMID: 29299156    Free PMC article.
Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: Rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy.
Emily Z Keung, Jen-Wei Tsai, +10 authors, Christina L Roland.
Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308306    Free PMC article.
Local Radiotherapy Affects Drug Pharmacokinetics-Exploration of a Neglected but Significant Uncertainty of Cancer Therapy.
Yu-Jen Chen, Tung-Hu Tsai, Li-Ying Wang, Chen-Hsi Hsieh.
Technol Cancer Res Treat, 2018 Jan 16; 16(6). PMID: 29332468    Free PMC article.
Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression.
Dewan Md Sakib Hossain, Sarah Javaid, +8 authors, Alissa Chackerian.
J Clin Invest, 2018 Jan 18; 128(2). PMID: 29337311    Free PMC article.
CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy.
Gwendolyn J McGinnis, Jacob Raber.
Immunotherapy, 2018 Jan 18; 9(11). PMID: 29338610    Free PMC article.
Adoptive immunotherapy shows encouraging benefit on non-small cell lung cancer: a systematic review and meta-analysis.
Binghao Zhao, Wenxiong Zhang, +2 authors, Yiping Wei.
Oncotarget, 2018 Jan 20; 8(68). PMID: 29348890    Free PMC article.
Microsatellite stability and mismatch repair proficiency in nasopharyngeal carcinoma may not predict programmed death-1 blockade resistance.
Xiyi Liao, Liang Zhao, +5 authors, Qin Lin.
Oncotarget, 2018 Jan 20; 8(68). PMID: 29348907    Free PMC article.
[Durvalumab improves prognosis of stage III non-small-cell lung cancer after definitive chemoradiotherapy].
Markus Hecht, Udo S Gaipl, Rainer Fietkau.
Strahlenther Onkol, 2018 Jan 28; 194(3). PMID: 29374302
Current perspectives on bone metastases in castrate-resistant prostate cancer.
Christopher Logothetis, Michael J Morris, Robert Den, Robert E Coleman.
Cancer Metastasis Rev, 2018 Jan 31; 37(1). PMID: 29380085    Free PMC article.
Radiation effects on antitumor immune responses: current perspectives and challenges.
Thomas Walle, Rafael Martinez Monge, +3 authors, Fernando Lecanda.
Ther Adv Med Oncol, 2018 Feb 01; 10. PMID: 29383033    Free PMC article.
Highly Cited. Review.
Expected Paradigm Shift in Brain Metastases Therapy-Immune Checkpoint Inhibitors.
Vishal Jindal, Sorab Gupta.
Mol Neurobiol, 2018 Feb 01; 55(8). PMID: 29383686
Recent advances in the biology and treatment of brain metastases of non-small cell lung cancer: summary of a multidisciplinary roundtable discussion.
Matthias Preusser, Frank Winkler, +5 authors, Christoph Zielinski.
ESMO Open, 2018 Feb 02; 3(1). PMID: 29387475    Free PMC article.
PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation.
Megan Morisada, Paul E Clavijo, +7 authors, Clint T Allen.
Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399393    Free PMC article.
Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer.
Olivier Belzile, Xianming Huang, +4 authors, Bruce D Freimark.
Immunotargets Ther, 2018 Feb 09; 7. PMID: 29417044    Free PMC article.
Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
Jason J Luke, Jeffrey M Lemons, +17 authors, Steven J Chmura.
J Clin Oncol, 2018 Feb 14; 36(16). PMID: 29437535    Free PMC article.
Highly Cited.
Using immunotherapy to boost the abscopal effect.
Wilfred Ngwa, Omoruyi Credit Irabor, +3 authors, Silvia C Formenti.
Nat Rev Cancer, 2018 Feb 17; 18(5). PMID: 29449659    Free PMC article.
Highly Cited. Review.
Exploring the rationale for combining ionizing radiation and immune checkpoint blockade in head and neck cancer.
Megan Morisada, Michael Chamberlin, Clint Allen.
Head Neck, 2018 Feb 21; 40(6). PMID: 29461655    Free PMC article.
The Abscopal Effect in the Era of Cancer Immunotherapy: a Spontaneous Synergism Boosting Anti-tumor Immunity?
Zuzana Hlavata, Cinzia Solinas, +4 authors, Mario Scartozzi.
Target Oncol, 2018 Feb 23; 13(2). PMID: 29470785
Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model.
Yuri Kosinsky, Simon J Dovedi, +6 authors, Gabriel Helmlinger.
J Immunother Cancer, 2018 Mar 01; 6(1). PMID: 29486799    Free PMC article.
IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma.
Erik Ladomersky, Lijie Zhai, +18 authors, Derek A Wainwright.
Clin Cancer Res, 2018 Mar 04; 24(11). PMID: 29500275    Free PMC article.
Highly Cited.
Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies.
Michael Rückert, Lisa Deloch, +3 authors, Udo S Gaipl.
Strahlenther Onkol, 2018 Mar 04; 194(6). PMID: 29500551
Highly Cited. Review.
Immunotherapy for Head and Neck Squamous Cell Carcinoma.
Jessica Moskovitz, Jennifer Moy, Robert L Ferris.
Curr Oncol Rep, 2018 Mar 05; 20(2). PMID: 29502288    Free PMC article.
Immune checkpoint inhibitors in neuroendocrine tumors: A single institution experience with review of literature.
Aman Chauhan, Millicent Horn, +4 authors, Lowell Anthony.
Oncotarget, 2018 Mar 07; 9(10). PMID: 29507655    Free PMC article.
Engineering Vaccines to Reprogram Immunity against Head and Neck Cancer.
Y S Tan, K Sansanaphongpricha, +3 authors, Y L Lei.
J Dent Res, 2018 Mar 14; 97(6). PMID: 29533731    Free PMC article.
Combined modality radiation therapy promotes tolerogenic myeloid cell populations and STAT3-related gene expression in head and neck cancer patients.
Sagus Sampath, Haejung Won, +6 authors, Marcin Kortylewski.
Oncotarget, 2018 Mar 16; 9(13). PMID: 29541413    Free PMC article.
The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules.
Kimberly M Arnold, Nicole J Flynn, +5 authors, Jennifer Sims-Mourtada.
Cancer Growth Metastasis, 2018 Mar 20; 11. PMID: 29551910    Free PMC article.
Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions.
Yifan Wang, Weiye Deng, +4 authors, Steven H Lin.
Front Pharmacol, 2018 Mar 21; 9. PMID: 29556198    Free PMC article.
Highly Cited. Review.
Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes.
Kalpana Mujoo, Clayton R Hunt, +5 authors, Tej K Pandita.
Mol Cancer Res, 2018 Mar 30; 16(8). PMID: 29592896    Free PMC article.
Immune checkpoint inhibitors in small cell lung cancer.
Suchita Pakkala, Taofeek K Owonikoko.
J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593891    Free PMC article.
Anti PD-L1 DUrvalumab combined with Cetuximab and RadiOtherapy in locally advanced squamous cell carcinoma of the head and neck: A phase I/II study (DUCRO).
Pierluigi Bonomo, Isacco Desideri, +7 authors, Lorenzo Livi.
Clin Transl Radiat Oncol, 2018 Mar 30; 9. PMID: 29594250    Free PMC article.
Radiotherapy-induced anti-tumor immune response and immune-related adverse events in a case of recurrent nasopharyngeal carcinoma undergoing anti-PD-1 immunotherapy.
T Finazzi, T Rordorf, +3 authors, H I Garcia Schueler.
BMC Cancer, 2018 Apr 08; 18(1). PMID: 29625593    Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Beyond checkpoint inhibition - Immunotherapeutical strategies in combination with radiation.
F Eckert, U S Gaipl, +4 authors, D Zips.
Clin Transl Radiat Oncol, 2017 Feb 04; 2. PMID: 29657997    Free PMC article.
The expression profile of PD-L1 and CD8+ lymphocyte in pituitary adenomas indicating for immunotherapy.
Peng-Fei Wang, Ting-Jian Wang, +4 authors, Chang-Xiang Yan.
J Neurooncol, 2018 Apr 24; 139(1). PMID: 29680903
Immunotherapy after chemoradiotherapy in stage III non-small cell lung cancer: a new standard of care?
Anna W Chalmers, Shiven B Patel, Wallace Akerley.
J Thorac Dis, 2018 May 01; 10(3). PMID: 29707266    Free PMC article.
PD-L1 expression in medulloblastoma: an evaluation by subgroup.
Allison M Martin, Christopher J Nirschl, +19 authors, Michael Lim.
Oncotarget, 2018 May 04; 9(27). PMID: 29721192    Free PMC article.
Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity.
Marka R Crittenden, Lauren Zebertavage, +7 authors, Michael J Gough.
Sci Rep, 2018 May 05; 8(1). PMID: 29725089    Free PMC article.
Precision radiotherapy for patients with locally advanced non-small cell lung cancer in the era of immunotherapy and precision medicine.
Hidehito Horinouch.
Transl Lung Cancer Res, 2018 May 22; 7(Suppl 2). PMID: 29780707    Free PMC article.
Radiation Followed by OX40 Stimulation Drives Local and Abscopal Antitumor Effects in an Anti-PD1-Resistant Lung Tumor Model.
Sharareh Niknam, Hampartsoum B Barsoumian, +15 authors, James W Welsh.
Clin Cancer Res, 2018 May 23; 24(22). PMID: 29784675    Free PMC article.
Bacillus Calmette-Guérin and anti-PD-L1 combination therapy boosts immune response against bladder cancer.
Yonghua Wang, Jing Liu, +6 authors, Haitao Niu.
Onco Targets Ther, 2018 May 31; 11. PMID: 29844686    Free PMC article.
Durvalumab after chemo-radiotherapy in stage III non-small cell lung cancer.
Jaseela Chiramel, Rebecca Tay, Raffaele Califano.
J Thorac Dis, 2018 Jun 01; 10(Suppl 9). PMID: 29850180    Free PMC article.
Durvalumab after chemoradiotherapy in stage III non-small cell lung cancer.
Pascale Tomasini, Laurent Greillier, +2 authors, Fabrice Barlesi.
J Thorac Dis, 2018 Jun 01; 10(Suppl 9). PMID: 29850182    Free PMC article.
Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens.
Mengjia Song, Xinfeng Chen, Liping Wang, Yi Zhang.
Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861603    Free PMC article.
The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent.
Jessica M S Jutzy, Jeffrey M Lemons, Jason J Luke, Steven J Chmura.
Int J Breast Cancer, 2018 Jun 05; 2018. PMID: 29862083    Free PMC article.
Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination.
Jun Gong, Thang Q Le, +2 authors, Richard Tuli.
J Immunother Cancer, 2018 Jun 06; 6(1). PMID: 29866197    Free PMC article.
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap.
Wantong Song, Limei Shen, +7 authors, Leaf Huang.
Nat Commun, 2018 Jun 10; 9(1). PMID: 29884866    Free PMC article.
Highly Cited.
Tumor molecular profiling of responders and non-responders following pembrolizumab monotherapy in chemotherapy resistant advanced cervical cancer.
N Y L Ngoi, V Heong, +9 authors, D S P Tan.
Gynecol Oncol Rep, 2018 Jun 13; 24. PMID: 29892689    Free PMC article.
Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy.
Osama Mohamad, Alberto Diaz de Leon, +17 authors, Raquibul Hannan.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900043    Free PMC article.
Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy.
Kaiyuan Ni, Guangxu Lan, +7 authors, Wenbin Lin.
Nat Commun, 2018 Jun 17; 9(1). PMID: 29907739    Free PMC article.
Immune checkpoint inhibitors and radiosurgery for newly diagnosed melanoma brain metastases.
Tyler P Robin, Robert E Breeze, +12 authors, Arthur K Liu.
J Neurooncol, 2018 Jun 18; 140(1). PMID: 29909499    Free PMC article.
Is there a room for immune checkpoint inhibitors in early stage non-small cell lung cancer?
Elisa Gobbini, Matteo Giaj Levra.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951294    Free PMC article.
Combining immunotherapy and radiotherapy in lung cancer.
Neeraj Bhalla, Rachel Brooker, Michael Brada.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951296    Free PMC article.
Shining light on advanced NSCLC in 2017: combining immune checkpoint inhibitors.
Meng Qiao, Tao Jiang, Caicun Zhou.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951304    Free PMC article.
ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation.
Frank P Vendetti, Pooja Karukonda, +13 authors, Christopher J Bakkenist.
J Clin Invest, 2018 Jun 29; 128(9). PMID: 29952768    Free PMC article.
Highly Cited.
Biological effects of radiation on cancer cells.
Jin-Song Wang, Hai-Juan Wang, Hai-Li Qian.
Mil Med Res, 2018 Jul 01; 5(1). PMID: 29958545    Free PMC article.
Combined VLA-4-Targeted Radionuclide Therapy and Immunotherapy in a Mouse Model of Melanoma.
Jaeyeon Choi, Wissam Beaino, +5 authors, Carolyn J Anderson.
J Nucl Med, 2018 Jul 01; 59(12). PMID: 29959213    Free PMC article.
Lymphocyte-Activation Gene-3 Expression and Prognostic Value in Neoadjuvant-Treated Triple-Negative Breast Cancer.
Yunxuan Wang, Tieying Dong, +3 authors, Qingyuan Zhang.
J Breast Cancer, 2018 Jul 03; 21(2). PMID: 29963107    Free PMC article.
Personalizing Radiation Treatment Delivery in the Management of Breast Cancer.
Kamran A Ahmed, G Daniel Grass, +7 authors, Roberto Diaz.
Int J Breast Cancer, 2018 Jul 10; 2018. PMID: 29984003    Free PMC article.
The influence of radiation in the context of developing combination immunotherapies in cancer.
Jamie Honeychurch, Timothy M Illidge.
Ther Adv Vaccines Immunother, 2018 Jul 13; 5(6). PMID: 29998216    Free PMC article.
Key mechanisms involved in ionizing radiation-induced systemic effects. A current review.
Ifigeneia V Mavragani, Danae A Laskaratou, +4 authors, Alexandros G Georgakilas.
Toxicol Res (Camb), 2015 Aug 11; 5(1). PMID: 30090323    Free PMC article.
Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing.
Lin-Lin Sun, Ri-Yao Yang, +8 authors, Mien-Chie Hung.
Am J Cancer Res, 2018 Aug 11; 8(7). PMID: 30094103    Free PMC article.
Combining Immune Checkpoint Inhibitors With Conventional Cancer Therapy.
Yiyi Yan, Anagha Bangalore Kumar, +4 authors, Haidong Dong.
Front Immunol, 2018 Aug 14; 9. PMID: 30100909    Free PMC article.
Highly Cited. Review.
Myeloid-Derived Suppressor Cells as a Regulator of Immunity in Organ Transplantation.
Tsukasa Nakamura, Hidetaka Ushigome.
Int J Mol Sci, 2018 Aug 15; 19(8). PMID: 30103447    Free PMC article.
The Expanding Role of Radiosurgery for Brain Metastases.
Mark O'Beirn, Helen Benghiat, +5 authors, Paul Sanghera.
Medicines (Basel), 2018 Aug 17; 5(3). PMID: 30110927    Free PMC article.
Abscopal effect of radiotherapy combined with immune checkpoint inhibitors.
Yang Liu, Yinping Dong, +3 authors, Jinming Yu.
J Hematol Oncol, 2018 Aug 18; 11(1). PMID: 30115069    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options.
Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül.
Front Immunol, 2018 Aug 31; 9. PMID: 30158932    Free PMC article.
Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.
Yuzhu Hou, Hua Liang, +10 authors, Yang-Xin Fu.
Immunity, 2018 Sep 02; 49(3). PMID: 30170810    Free PMC article.
Activation of immune responses in patients with relapsed-metastatic head and neck cancer (CONFRONT phase I-II trial): Multimodality immunotherapy with avelumab, short-course radiotherapy, and cyclophosphamide.
Marco C Merlano, Anna M Merlotti, +9 authors, Renzo Corvò.
Clin Transl Radiat Oncol, 2018 Sep 07; 12. PMID: 30186977    Free PMC article.
Multi-institutional report on toxicities of concurrent nivolumab and radiation therapy.
Neha P Amin, Maliha Zainib, +2 authors, Malcolm D Mattes.
Adv Radiat Oncol, 2018 Sep 12; 3(3). PMID: 30202808    Free PMC article.
Robotic Stereotactic Radiosurgery in Melanoma Patients with Brain Metastases under Simultaneous Anti-PD-1 Treatment.
Maike Trommer-Nestler, Simone Marnitz, +9 authors, Christian Baues.
Int J Mol Sci, 2018 Sep 13; 19(9). PMID: 30205431    Free PMC article.
Advances in radiation therapy for thoracic malignancies.
Charles B Simone, Shahed N Badiyan, Pranshu Mohindra.
J Thorac Dis, 2018 Sep 13; 10(Suppl 21). PMID: 30206489    Free PMC article.
Combining immunotherapy with radiation therapy in thoracic oncology.
Shahed N Badiyan, Michael C Roach, +7 authors, Charles B Simone.
J Thorac Dis, 2018 Sep 13; 10(Suppl 21). PMID: 30206494    Free PMC article.
Long-term survival of locally advanced stage III non-small cell lung cancer patients treated with chemoradiotherapy and perspectives for the treatment with immunotherapy.
Martina Vrankar, Karmen Stanic.
Radiol Oncol, 2018 Sep 14; 52(3). PMID: 30210037    Free PMC article.
Immune Checkpoint Inhibition in Head and Neck Cancer.
Martin David Forster, Michael-John Devlin.
Front Oncol, 2018 Sep 14; 8. PMID: 30211111    Free PMC article.
Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression.
Robin Maximilian Awad, Yannick De Vlaeminck, +2 authors, Karine Breckpot.
Front Immunol, 2018 Sep 21; 9. PMID: 30233579    Free PMC article.
Highly Cited. Review.
Expression of PD-1 and PD-L1 increase in consecutive biopsies in patients with classical Hodgkin lymphoma.
Peter Hollander, Rose-Marie Amini, +3 authors, Ingrid Glimelius.
PLoS One, 2018 Sep 28; 13(9). PMID: 30261066    Free PMC article.
Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response.
Roger Gilabert-Oriol, Gemma M Ryan, +3 authors, Marcel B Bally.
Int J Mol Sci, 2018 Sep 29; 19(10). PMID: 30261606    Free PMC article.
Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy.
Jinfang Zhang, Fabin Dang, Junming Ren, Wenyi Wei.
Trends Biochem Sci, 2018 Oct 06; 43(12). PMID: 30287140    Free PMC article.
Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences.
Xinyu Yan, Shouyue Zhang, +3 authors, Heng Xu.
Front Pharmacol, 2018 Oct 09; 9. PMID: 30294272    Free PMC article.
Accelerated, but not conventional, radiotherapy of murine B-cell lymphoma induces potent T cell-mediated remissions.
Suparna Dutt, Michelle B Atallah, +7 authors, Samuel Strober.
Blood Adv, 2018 Oct 12; 2(19). PMID: 30301812    Free PMC article.
Low PD-L1 Expression Strongly Correlates with Local Recurrence in Epstein-Barr Virus-Positive Nasopharyngeal Carcinoma after Radiation-Based Therapy.
Yu-Jen Liu, Ngan-Ming Tsang, +4 authors, Wen-Yu Chuang.
Cancers (Basel), 2018 Oct 12; 10(10). PMID: 30304846    Free PMC article.
Safety of combined PD-1 pathway inhibition and radiation therapy for non-small-cell lung cancer: A multicentric retrospective study from the GFPC.
Paul Lesueur, Alexandre Escande, +9 authors, Radj Gervais.
Cancer Med, 2018 Oct 13; 7(11). PMID: 30311424    Free PMC article.
Immune Checkpoint Inhibitors for the Treatment of Central Nervous System (CNS) Metastatic Disease.
Suneel D Kamath, Priya U Kumthekar.
Front Oncol, 2018 Oct 16; 8. PMID: 30319977    Free PMC article.
Multimodal detection of PD-L1: reasonable biomarkers for immune checkpoint inhibitor.
Qiao Yang, Zihan Xu, +3 authors, Jianguo Sun.
Am J Cancer Res, 2018 Oct 17; 8(9). PMID: 30323963    Free PMC article.
Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels.
Deepika Nair, Emelie Rådestad, +6 authors, Aristi P Fernandes.
Front Oncol, 2018 Oct 17; 8. PMID: 30324091    Free PMC article.
The Role of Immunotherapy and Radiation Therapy in Tumor Chemosensitivity in Advanced Head and Neck Cancer.
Saad O Atiq, Osman O Atiq, +5 authors, Omar T Atiq.
Am J Case Rep, 2018 Oct 20; 19. PMID: 30333474    Free PMC article.
Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II-III colorectal cancer.
Chih-Yang Huang, Shu-Fen Chiang, +4 authors, K S Clifford Chao.
Sci Rep, 2018 Oct 26; 8(1). PMID: 30353144    Free PMC article.
[Predictive value of PD-L1 diagnostics].
H-U Schildhaus.
Pathologe, 2018 Oct 28; 39(6). PMID: 30367225
Generating antitumor immunity by targeted radiation therapy: Role of dose and fractionation.
Eric C Ko, Kimberly Thomas Benjamin, Silvia C Formenti.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370347    Free PMC article.
Role of noninvasive molecular imaging in determining response.
Ariel E Marciscano, Daniel L J Thorek.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370353    Free PMC article.
Exploring the Concept of Radiation "Booster Shot" in Combination with an Anti-PD-L1 mAb to Enhance Anti-Tumor Immune Effects in Mouse Pancreas Tumors.
Michael Chuong, Elizabeth T Chang, +4 authors, France Carrier.
J Clin Oncol Res, 2017 Jan 01; 5(2). PMID: 30417086    Free PMC article.
Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade.
Keaton I Jones, Jiske Tiersma, +4 authors, Ruth J Muschel.
EMBO Mol Med, 2018 Nov 18; 10(12). PMID: 30442705    Free PMC article.
Radiation therapy and immunotherapy-a potential combination in cancer treatment.
N Asna, A Livoff, +4 authors, M Schaffer.
Curr Oncol, 2018 Nov 23; 25(5). PMID: 30464697    Free PMC article.
Crosstalk Between PD-1/PD-L1 Blockade and Its Combinatorial Therapies in Tumor Immune Microenvironment: A Focus on HNSCC.
Weimin Lin, Miao Chen, +2 authors, Qianming Chen.
Front Oncol, 2018 Dec 07; 8. PMID: 30519541    Free PMC article.
Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma.
Lukas W Pfannenstiel, Corey McNeilly, +4 authors, Brian R Gastman.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546944    Free PMC article.
Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics.
Sayuri Miyauchi, Sangwoo S Kim, +6 authors, Andrew B Sharabi.
Clin Cancer Res, 2019 Mar 01; 25(14). PMID: 30814108    Free PMC article.
Hyperprogressive disease after treatment with pembrolizumab in lung adenocarcinoma: An autopsy case study.
Yuko Tanaka, Osamu Matsubara, +3 authors, Toshihiro Shirai.
Respir Med Case Rep, 2019 Jun 30; 28. PMID: 31249779    Free PMC article.
Future of Radiotherapy in Nasopharyngeal Carcinoma.
Xue-Song Sun, Xiao-Yun Li, +2 authors, Hai-Qiang Mai.
Br J Radiol, 2019 Jul 03; 92(1102). PMID: 31265322    Free PMC article.
A Pilot Study of the PD-1 Targeting Agent AMP-224 Used With Low-Dose Cyclophosphamide and Stereotactic Body Radiation Therapy in Patients With Metastatic Colorectal Cancer.
Charalampos S Floudas, Gagandeep Brar, +13 authors, Changqing Xie.
Clin Colorectal Cancer, 2019 Jul 29; 18(4). PMID: 31351862    Free PMC article.
Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation.
Jianzhou Chen, Yunhong Cao, +3 authors, Ruth J Muschel.
J Clin Invest, 2019 Sep 05; 129(10). PMID: 31483286    Free PMC article.
Real-World Outcomes and Prognostic Factors in Patients Receiving Nivolumab Therapy for Recurrent or Metastatic Head and Neck Carcinoma.
Ryusuke Hori, Shogo Shinohara, +12 authors, Koichi Omori.
Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500103    Free PMC article.
Myeloid-Derived Suppressive Cells Promote B cell-Mediated Immunosuppression via Transfer of PD-L1 in Glioblastoma.
Catalina Lee-Chang, Aida Rashidi, +13 authors, Maciej S Lesniak.
Cancer Immunol Res, 2019 Sep 19; 7(12). PMID: 31530559    Free PMC article.
Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11.
Xueting Lang, Michael D Green, +20 authors, Weiping Zou.
Cancer Discov, 2019 Sep 27; 9(12). PMID: 31554642    Free PMC article.
Highly Cited.
β2 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells.
Hemn Mohammadpour, Cameron R MacDonald, +6 authors, Elizabeth A Repasky.
J Clin Invest, 2019 Oct 01; 129(12). PMID: 31566578    Free PMC article.
Combination of checkpoint inhibitors with radiotherapy in esophageal squamous cell carcinoma treatment: A novel strategy.
Xiu-Yong Liao, Chao-Yuan Liu, +2 authors, Tao Zhang.
Oncol Lett, 2019 Oct 16; 18(5). PMID: 31612012    Free PMC article.
Abscopal Effect Following Proton Beam Radiotherapy in a Patient With Inoperable Metastatic Retroperitoneal Sarcoma.
Randall J Brenneman, Nima Sharifai, +6 authors, Brian C Baumann.
Front Oncol, 2019 Oct 17; 9. PMID: 31616634    Free PMC article.
Randomized phase II trial reporting overall survival advantage by adding local consolidative therapy to systemic therapy for oligometastatic non-small cell lung cancer: another step forward on the long road of evidence-based medicine for oligometastatic disease.
Paul Windisch, Matthias Guckenberger.
J Thorac Dis, 2019 Oct 22; 11(Suppl 15). PMID: 31632771    Free PMC article.
The Microenvironment of Pituitary Tumors-Biological and Therapeutic Implications.
Mirela Diana Ilie, Alexandre Vasiljevic, Gérald Raverot, Philippe Bertolino.
Cancers (Basel), 2019 Oct 24; 11(10). PMID: 31640258    Free PMC article.
The role of exosomal PD-L1 in tumor progression and immunotherapy.
Feiting Xie, Mengxue Xu, +2 authors, Shengjun Wang.
Mol Cancer, 2019 Oct 28; 18(1). PMID: 31647023    Free PMC article.
Highly Cited. Review.
What is the role of radiotherapy for extensive-stage small cell lung cancer in the immunotherapy era?
Eric G Nesbit, Ticiana A Leal, Tim J Kruser.
Transl Lung Cancer Res, 2019 Nov 02; 8(Suppl 2). PMID: 31673520    Free PMC article.
Durvalumab for stage III non-small-cell lung cancer patients: clinical evidence and real-world experience.
Angela Botticella, Laura Mezquita, Cecile Le Pechoux, David Planchard.
Ther Adv Respir Dis, 2019 Nov 07; 13. PMID: 31686616    Free PMC article.
Recent advances and application of PD-1 blockade in sarcoma.
Wenli Zuo, Lingdi Zhao.
Onco Targets Ther, 2019 Nov 07; 12. PMID: 31692518    Free PMC article.
IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer.
Guoping Ding, Tao Shen, +3 authors, Liping Cao.
BMC Cancer, 2019 Nov 07; 19(1). PMID: 31694582    Free PMC article.
A preliminary Study on the Effect of Head and Neck Chemoradiotherapy on Systematic Immunity.
Weiqiang Huang, Yao Fan, +5 authors, Jian Guan.
Dose Response, 2019 Nov 07; 17(4). PMID: 31695581    Free PMC article.
Immune Checkpoint Inhibition in Hodgkin Lymphoma.
Ryan H Moy, Anas Younes.
Hemasphere, 2018 Feb 16; 2(1). PMID: 31723749    Free PMC article.
The Future of Combining Carbon-Ion Radiotherapy with Immunotherapy: Evidence and Progress in Mouse Models.
Takashi Shimokawa, Liqiu Ma, +2 authors, Takashi Imai.
Int J Part Ther, 2016 Jul 01; 3(1). PMID: 31772976    Free PMC article.
Advantages and Limitations in the Use of Combination Therapies with Charged Particle Radiation Therapy.
Koji Tsuboi.
Int J Part Ther, 2018 Jul 01; 5(1). PMID: 31773024    Free PMC article.
Is the Combination of Immunotherapy and Radiotherapy in Non-small Cell Lung Cancer a Feasible and Effective Approach?
Mathieu Spaas, Yolande Lievens.
Front Med (Lausanne), 2019 Dec 04; 6. PMID: 31788476    Free PMC article.
Evolving management of positive regional lymph nodes in melanoma: Past, present and future directions.
Rachel A Fayne, Francisco I Macedo, Steven E Rodgers, Mecker G Möller.
Oncol Rev, 2019 Dec 21; 13(2). PMID: 31857858    Free PMC article.
Sequential Ipilimumab After Chemoradiotherapy in Curative-Intent Treatment of Patients With Node-Positive Cervical Cancer.
Jyoti S Mayadev, Danielle Enserro, +8 authors, Russell J Schilder.
JAMA Oncol, 2019 Nov 28; 6(1). PMID: 31774464    Free PMC article.
Therapy Resistance in Neoadjuvantly Treated Gastric Cancer and Cancer of the Gastroesophageal Junction is Associated with an Increased Expression of Immune Checkpoint Inhibitors-Comparison Against a Therapy Naïve Cohort.
Hauke Schoop, Anna Bregenzer, +4 authors, Christoph Röcken.
Transl Oncol, 2019 Dec 23; 13(2). PMID: 31865179    Free PMC article.
Microparticles from tumors exposed to radiation promote immune evasion in part by PD-L1.
Michael Timaner, Ruslana Kotsofruk, +10 authors, Yuval Shaked.
Oncogene, 2019 Aug 31; 39(1). PMID: 31467431    Free PMC article.
Indoleamine 2,3-dioxygenase 1 and Programmed Cell Death-ligand 1 Co-expression Predicts Poor Pathologic Response and Recurrence in Esophageal Squamous Cell Carcinoma after Neoadjuvant Chemoradiotherapy.
Sha Zhou, Lei Zhao, +6 authors, Mian Xi.
Cancers (Basel), 2019 Feb 06; 11(2). PMID: 30717285    Free PMC article.
Separating or combining immune checkpoint inhibitors (ICIs) and radiotherapy in the treatment of NSCLC brain metastases.
Wang Li, Hong Yu.
J Cancer Res Clin Oncol, 2019 Dec 10; 146(1). PMID: 31813004
Efficacy of anti-PD-1 therapy for recurrence after chemoradiotherapy in locally advanced NSC LC.
Yoshiaki Amino, Satoru Kitazono, +8 authors, Makoto Nishio.
Int J Clin Oncol, 2019 Sep 12; 25(1). PMID: 31506751
Targeting innate sensing in the tumor microenvironment to improve immunotherapy.
Zhida Liu, Chuanhui Han, Yang-Xin Fu.
Cell Mol Immunol, 2019 Dec 18; 17(1). PMID: 31844141    Free PMC article.
Amplifying Outcomes: Checkpoint Inhibitor Combinations in First-Line Non-Small Cell Lung Cancer.
Barbara Melosky, Rosalyn Juergens, +5 authors, Quincy Chu.
Oncologist, 2019 May 30; 25(1). PMID: 31138727    Free PMC article.
A Novel Anti-PD-L1 Vaccine for Cancer Immunotherapy and Immunoprevention.
Jie Chen, Hui Liu, +7 authors, Si-Yi Chen.
Cancers (Basel), 2019 Dec 07; 11(12). PMID: 31805690    Free PMC article.
Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line.
Philipp Schröter, Laura Hartmann, +6 authors, Stefan Rieken.
Sci Rep, 2020 Jan 22; 10(1). PMID: 31959787    Free PMC article.
Impact of histology on patterns of failure and clinical outcomes in patients treated with definitive chemoradiotherapy for locally advanced non-small cell lung cancer.
Hitoshi Ito, Yukinori Matsuo, +4 authors, Takashi Mizowaki.
Int J Clin Oncol, 2019 Nov 02; 25(2). PMID: 31667664
The PEMBRO-RT phase II randomized trial and the evolution of therapy for metastatic non-small cell lung cancer: a historical perspective.
Steven E Schild.
Ann Transl Med, 2020 Feb 06; 7(Suppl 8). PMID: 32016013    Free PMC article.
A first attempt to establish a definition of oligometastatic non-small cell lung cancer by a European consensus group.
Koji Haratani, Masayuki Takeda, Kazuhiko Nakagawa.
J Thorac Dis, 2020 Feb 08; 11(12). PMID: 32030287    Free PMC article.
Local consolidative therapy for oligometastatic patients with stage IV non-small cell lung cancer may improve survival, but unanswered questions remain.
Jose M Pacheco, Drew Moghanaki.
Transl Lung Cancer Res, 2020 Feb 11; 8(Suppl 4). PMID: 32038926    Free PMC article.
Immune biological rationales for the design of combined radio- and immunotherapies.
Michael Hader, Benjamin Frey, +2 authors, Udo S Gaipl.
Cancer Immunol Immunother, 2020 Jan 19; 69(2). PMID: 31953578    Free PMC article.
Irradiation or temozolomide chemotherapy enhances anti-CD47 treatment of glioblastoma.
Sharareh Gholamin, Osama A Youssef, +8 authors, Samuel H Cheshier.
Innate Immun, 2019 Sep 25; 26(2). PMID: 31547758    Free PMC article.
The changing role of radiation therapy in the management of oligometastatic disease.
H Tharmalingham, P J Hoskin.
Tech Innov Patient Support Radiat Oncol, 2017 Feb 16; 1. PMID: 32095538    Free PMC article.
Immune Checkpoint Inhibitors for the Treatment of Unresectable Stage III Non-Small Cell Lung Cancer: Emerging Mechanisms and Perspectives.
Hiroyuki Inoue, Isamu Okamoto.
Lung Cancer (Auckl), 2020 Feb 27; 10. PMID: 32099495    Free PMC article.
Radiotherapy as a Backbone for Novel Concepts in Cancer Immunotherapy.
Julijan Kabiljo, Felix Harpain, Sebastian Carotta, Michael Bergmann.
Cancers (Basel), 2020 Jan 08; 12(1). PMID: 31905723    Free PMC article.
Hypofractionated Irradiation Suppressed the Off-Target Mouse Hepatocarcinoma Growth by Inhibiting Myeloid-Derived Suppressor Cell-Mediated Immune Suppression.
Junying Chen, Zeng Wang, +11 authors, Lurong Zhang.
Front Oncol, 2020 Mar 03; 10. PMID: 32117702    Free PMC article.
PD-L1 Expression in Circulating Tumor Cells Increases during Radio(chemo)therapy and Indicates Poor Prognosis in Non-small Cell Lung Cancer.
Yang Wang, Tae Hyun Kim, +9 authors, Sunitha Nagrath.
Sci Rep, 2019 Jan 27; 9(1). PMID: 30679441    Free PMC article.
Highly Cited.
STING, DCs and the link between innate and adaptive tumor immunity.
Ralph E Vatner, Edith M Janssen.
Mol Immunol, 2017 Dec 24; 110. PMID: 29273394    Free PMC article.
Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation.
P Jack Hoopes, Robert J Wagner, +8 authors, Steven N Fiering.
Mol Pharm, 2018 Apr 04; 15(9). PMID: 29613803    Free PMC article.
Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect.
María E Rodríguez-Ruiz, Claire Vanpouille-Box, +2 authors, Sandra Demaria.
Trends Immunol, 2018 Jul 14; 39(8). PMID: 30001871    Free PMC article.
Highly Cited. Review.
IFNγ PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy.
Heather M Gibson, Brooke N McKnight, +6 authors, Nerissa T Viola-Villegas.
Cancer Res, 2018 Aug 18; 78(19). PMID: 30115693    Free PMC article.
Anti-drug antibodies to LMB-100 are enhanced by mAbs targeting OX40 and CTLA4 but not by mAbs targeting PD1 or PDL-1.
Ronit Mazor, Emily King, Ira Pastan.
Cell Immunol, 2018 Sep 15; 334. PMID: 30213644    Free PMC article.
Tumor regression after combination of radiation and PD-1 antibody nivolumab treatment in a patient with metastatic mediastinal leiomyosarcoma: a case report.
Chen Xi, Zhang Wencheng, +7 authors, Wang Ping.
Cancer Biol Ther, 2018 Nov 06; 20(4). PMID: 30388926    Free PMC article.
Immunotherapies based on PD-1/PD-L1 pathway inhibitors in ovarian cancer treatment.
A Pawłowska, D Suszczyk, +3 authors, I Wertel.
Clin Exp Immunol, 2018 Dec 26; 195(3). PMID: 30582756    Free PMC article.
Immunomodulation of the Tumor Microenvironment: Turn Foe Into Friend.
Hanne Locy, Sven de Mey, +3 authors, Sarah K Maenhout.
Front Immunol, 2019 Jan 09; 9. PMID: 30619273    Free PMC article.
Highly Cited. Review.
Potential Role of CXCR4 Targeting in the Context of Radiotherapy and Immunotherapy of Cancer.
Franziska Eckert, Karin Schilbach, +5 authors, Stephan M Huber.
Front Immunol, 2019 Jan 10; 9. PMID: 30622535    Free PMC article.
A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis.
Hila Doron, Tobias Pukrop, Neta Erez.
Cancer Res, 2019 Jan 27; 79(3). PMID: 30679177    Free PMC article.
Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?
Ruben S A Goedegebuure, Leonie K de Klerk, +2 authors, Victor L J L Thijssen.
Front Immunol, 2019 Jan 30; 9. PMID: 30692993    Free PMC article.
Overcoming Resistance to Combination Radiation-Immunotherapy: A Focus on Contributing Pathways Within the Tumor Microenvironment.
Laurel B Darragh, Ayman J Oweida, Sana D Karam.
Front Immunol, 2019 Feb 16; 9. PMID: 30766539    Free PMC article.
The Role of Radiation Oncology in Immuno-Oncology.
Xiangjiao Meng, Rui Feng, +2 authors, Jinming Yu.
Oncologist, 2019 Mar 02; 24(Suppl 1). PMID: 30819830    Free PMC article.
90Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin's Lymphoma.
Reinier Hernandez, Kirsti L Walker, +12 authors, Jamey P Weichert.
Commun Biol, 2019 Mar 02; 2. PMID: 30820474    Free PMC article.
Direct and antibody-dependent cell-mediated cytotoxicity of head and neck squamous cell carcinoma cells by high-affinity natural killer cells.
Jay Friedman, Michelle Padget, +3 authors, Clint Allen.
Oral Oncol, 2019 Mar 09; 90. PMID: 30846174    Free PMC article.
Immune targets in the tumor microenvironment treated by radiotherapy.
Omer M Ozpiskin, Lu Zhang, Jian Jian Li.
Theranostics, 2019 Mar 15; 9(5). PMID: 30867826    Free PMC article.
Highly Cited. Review.
Radiotherapy is an independent prognostic marker of favorable prognosis in non-small cell lung cancer patients after treatment with the immune checkpoint inhibitor, nivolumab.
Ou Yamaguchi, Kyoichi Kaira, +9 authors, Hiroshi Kagamu.
Thorac Cancer, 2019 Mar 20; 10(4). PMID: 30888716    Free PMC article.
Pancreatic Tumor Microenvironment Modulation by EphB4-ephrinB2 Inhibition and Radiation Combination.
Shelby Lennon, Ayman Oweida, +17 authors, Sana D Karam.
Clin Cancer Res, 2019 Apr 05; 25(11). PMID: 30944125    Free PMC article.
[Durvalumab after chemoradiotherapy is currently the most promising treatment for stage III NSCLC].
Martin Wilhelm.
Strahlenther Onkol, 2019 Apr 06; 195(7). PMID: 30949719
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.
Mauro Poggio, Tianyi Hu, +8 authors, Robert Blelloch.
Cell, 2019 Apr 06; 177(2). PMID: 30951669    Free PMC article.
Highly Cited.
Noninvasive Imaging and Quantification of Radiotherapy-Induced PD-L1 Upregulation with 89Zr-Df-Atezolizumab.
Emily B Ehlerding, Hye Jin Lee, +5 authors, Weibo Cai.
Bioconjug Chem, 2019 Apr 12; 30(5). PMID: 30973703    Free PMC article.
Feline XLF accumulates at DNA damage sites in a Ku-dependent manner.
Manabu Koike, Yasutomo Yutoku, Aki Koike.
FEBS Open Bio, 2019 May 23; 9(6). PMID: 31115163    Free PMC article.
PD-L1 detection using 89Zr-atezolizumab immuno-PET in renal cell carcinoma tumorgrafts from a patient with favorable nivolumab response.
Joseph Vento, Aditi Mulgaonkar, +11 authors, James Brugarolas.
J Immunother Cancer, 2019 Jun 04; 7(1). PMID: 31155004    Free PMC article.
Abscopal Effects in Radio-Immunotherapy-Response Analysis of Metastatic Cancer Patients With Progressive Disease Under Anti-PD-1 Immune Checkpoint Inhibition.
Maike Trommer, Sin Yuin Yeo, +10 authors, Christian Baues.
Front Pharmacol, 2019 Jun 04; 10. PMID: 31156434    Free PMC article.
Pre-clinical blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma.
Christelle Vincent-Fabert, Lilian Roland, +2 authors, Nathalie Faumont.
Cell Commun Signal, 2019 Aug 07; 17(1). PMID: 31382969    Free PMC article.
MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.
Zhuochao Liu, Junxiang Wen, +9 authors, Weibin Zhang.
Aging (Albany NY), 2020 Jan 26; 12(2). PMID: 31981455    Free PMC article.
Phase 1 Trial of Pembrolizumab Administered Concurrently With Chemoradiotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial.
Salma K Jabbour, Abigail T Berman, +9 authors, Jyoti Malhotra.
JAMA Oncol, 2020 Feb 23; 6(6). PMID: 32077891    Free PMC article.
The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance.
Yarong Du, Dong Pan, +4 authors, Burong Hu.
Oxid Med Cell Longev, 2020 Mar 20; 2020. PMID: 32190169    Free PMC article.
Advances and challenges in immunotherapy of small cell lung cancer.
Hanfei Guo, Lingyu Li, Jiuwei Cui.
Chin J Cancer Res, 2020 Mar 21; 32(1). PMID: 32194311    Free PMC article.
T cell recruitment triggered by optimal dose platinum compounds contributes to the therapeutic efficacy of sequential PD-1 blockade in a mouse model of colon cancer.
Deqiang Fu, Jichun Wu, +4 authors, Qiuyu Zhang.
Am J Cancer Res, 2020 Mar 21; 10(2). PMID: 32195021    Free PMC article.
Determinants of Resistance to Checkpoint Inhibitors.
Linda Tran, Dan Theodorescu.
Int J Mol Sci, 2020 Mar 01; 21(5). PMID: 32111080    Free PMC article.
Putative Abscopal Effect in Three Patients Treated by Combined Radiotherapy and Modulated Electrohyperthermia.
Mau-Shin Chi, Minesh P Mehta, +6 authors, Kwan-Hwa Chi.
Front Oncol, 2020 Mar 27; 10. PMID: 32211319    Free PMC article.
Quantitative PET imaging of PD-L1 expression in xenograft and syngeneic tumour models using a site-specifically labelled PD-L1 antibody.
Camilla Christensen, Lotte K Kristensen, +2 authors, Andreas Kjaer.
Eur J Nucl Med Mol Imaging, 2019 Dec 29; 47(5). PMID: 31883023    Free PMC article.
Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration.
Jieyu Xu, Yuan Luo, +11 authors, Conghua Xie.
Int J Biol Sci, 2020 Apr 01; 16(9). PMID: 32226302    Free PMC article.
Current status and progress of concurrent chemoradiotherapy in patients with locally advanced non-small cell lung cancer prior to the approval of durvalumab.
Tomoya Fukui, Shinji Hosotani, +13 authors, Katsuhiko Naoki.
Thorac Cancer, 2020 Feb 15; 11(4). PMID: 32057187    Free PMC article.
HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.
Xiaobo Luo, Christopher R Donnelly, +21 authors, Yu L Lei.
J Clin Invest, 2019 Dec 25; 130(4). PMID: 31874109    Free PMC article.
Interferon-Induced IDO1 Mediates Radiation Resistance and Is a Therapeutic Target in Colorectal Cancer.
Baosheng Chen, David M Alvarado, +5 authors, Matthew A Ciorba.
Cancer Immunol Res, 2020 Mar 05; 8(4). PMID: 32127391    Free PMC article.
The emerging role of myeloid-derived suppressor cells in radiotherapy.
Changhee Kang, Seong-Yun Jeong, Si Yeol Song, Eun Kyung Choi.
Radiat Oncol J, 2020 Apr 02; 38(1). PMID: 32229803    Free PMC article.
Practical challenges in patients with stage III NSCLC receiving checkpoint inhibitors after chemoradiation.
Nikhil A Shukla, Nasser H Hanna.
Lung Cancer Manag, 2020 Apr 08; 9(1). PMID: 32256709    Free PMC article.
Immunotherapy and radiation therapy for gastrointestinal malignancies: hope or hype?
Shahed Badiyan, Adeel Kaiser, +4 authors, Michael Chuong.
Transl Gastroenterol Hepatol, 2020 Apr 08; 5. PMID: 32258525    Free PMC article.
Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation.
Jing Liu, Jie Zhou, +10 authors, JingBo Wu.
Front Immunol, 2019 Mar 16; 10. PMID: 30873170    Free PMC article.
Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors.
Franziska Eckert, Kerstin Zwirner, +3 authors, Stephan M Huber.
Front Immunol, 2019 Apr 02; 10. PMID: 30930892    Free PMC article.
The Multifactorial Role of PARP-1 in Tumor Microenvironment.
Juan Manuel Martí, Mónica Fernández-Cortés, +4 authors, Francisco Javier Oliver.
Cancers (Basel), 2020 Apr 05; 12(3). PMID: 32245040    Free PMC article.
Development and validation of an immune-related gene pairs signature in colorectal cancer.
Jianping Wu, Ying Zhao, +2 authors, Weilin Wang.
Oncoimmunology, 2019 May 31; 8(7). PMID: 31143520    Free PMC article.
Synergistic effects of anti-PDL-1 with ablative radiation comparing to other regimens with same biological effect dose based on different immunogenic response.
Maedeh Alinezhad, Mohsen Bakhshandeh, +3 authors, Seyed Amir Jalali.
PLoS One, 2020 Apr 15; 15(4). PMID: 32287292    Free PMC article.
Breast cancer immunology and immunotherapy: targeting the programmed cell death protein-1/programmed cell death protein ligand-1.
Jing Zhao, Jian Huang.
Chin Med J (Engl), 2020 Feb 28; 133(7). PMID: 32106121    Free PMC article.
Mathematical modeling of tumor-immune cell interactions.
Grace E Mahlbacher, Kara C Reihmer, Hermann B Frieboes.
J Theor Biol, 2019 Mar 06; 469. PMID: 30836073    Free PMC article.
National Cancer Institute (NCI) state of the science: Targeted radiosensitizers in colorectal cancer.
Thomas J George, Aaron J Franke, +16 authors, Mansoor M Ahmed.
Cancer, 2019 Apr 25; 125(16). PMID: 31017664    Free PMC article.
Recent Findings in the Regulation of Programmed Death Ligand 1 Expression.
Xiangfeng Shen, Lihong Zhang, +3 authors, Zhi-Xiang Xu.
Front Immunol, 2019 Jul 02; 10. PMID: 31258527    Free PMC article.
STING modulators: Predictive significance in drug discovery.
Xiangling Cui, Rongyu Zhang, Shan Cen, Jinming Zhou.
Eur J Med Chem, 2019 Aug 17; 182. PMID: 31419779    Free PMC article.
Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells.
Samantha S Beauford, Anita Kumari, Charlie Garnett-Benson.
BMC Immunol, 2020 Apr 18; 21(1). PMID: 32299365    Free PMC article.
Combination Strategies of Checkpoint Immunotherapy in Metastatic Breast Cancer.
Zhi Bing Liu, Luyan Zhang, Jia Bian, Jinbo Jian.
Onco Targets Ther, 2020 Apr 21; 13. PMID: 32308409    Free PMC article.
Modeling and Analyzing Stem-Cell Therapy toward Cancer: Evolutionary Game Theory Perspective.
Zahra Veisi, Heydar Khadem, Samin Ravanshadi.
Iran J Public Health, 2020 Apr 21; 49(1). PMID: 32309233    Free PMC article.
Liver metastases and the efficacy of the PD-1 or PD-L1 inhibitors in cancer: a meta-analysis of randomized controlled trials.
Shan Li, Shanquan Sun, +3 authors, Qing Gao.
Oncoimmunology, 2020 Apr 22; 9(1). PMID: 32313724    Free PMC article.
TENERGY: multicenter phase II study of Atezolizumab monotherapy following definitive Chemoradiotherapy with 5-FU plus Cisplatin in patients with unresectable locally advanced esophageal squamous cell carcinoma.
Hideaki Bando, Daisuke Kotani, +15 authors, Takashi Kojima.
BMC Cancer, 2020 Apr 22; 20(1). PMID: 32312286    Free PMC article.
Apatinib Combined with Local Irradiation Leads to Systemic Tumor Control via Reversal of Immunosuppressive Tumor Microenvironment in Lung Cancer.
Li-Jun Liang, Chen-Xi Hu, +12 authors, Xiao-Dong Jiang.
Cancer Res Treat, 2019 Sep 04; 52(2). PMID: 31476848    Free PMC article.
Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination.
Mathieu Grapin, Corentin Richard, +10 authors, Céline Mirjolet.
J Immunother Cancer, 2019 Jun 27; 7(1). PMID: 31238970    Free PMC article.
Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges.
A Pavan, I Attili, +3 authors, L Bonanno.
J Immunother Cancer, 2019 Aug 07; 7(1). PMID: 31383005    Free PMC article.
Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment.
Hiro Sato, Noriyuki Okonogi, Takashi Nakano.
Int J Clin Oncol, 2020 Apr 05; 25(5). PMID: 32246277    Free PMC article.
Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity.
Lauren K Zebertavage, Alejandro Alice, Marka R Crittenden, Michael J Gough.
Sci Rep, 2020 May 02; 10(1). PMID: 32355214    Free PMC article.
Alteration in tumoural PD-L1 expression and stromal CD8-positive tumour-infiltrating lymphocytes after concurrent chemo-radiotherapy for non-small cell lung cancer.
Kazue Yoneda, Taiji Kuwata, +7 authors, Fumihiro Tanaka.
Br J Cancer, 2019 Aug 08; 121(6). PMID: 31388183    Free PMC article.
Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy.
Michael J Gough, Shay Sharon, Marka R Crittenden, Kristina H Young.
Semin Radiat Oncol, 2020 May 10; 30(2). PMID: 32381295    Free PMC article.
Novel Radiation Therapy Paradigms and Immunomodulation: Heresies and Hope.
Suparna Dutt, Mansoor M Ahmed, Billy W Loo, Samuel Strober.
Semin Radiat Oncol, 2020 May 10; 30(2). PMID: 32381299    Free PMC article.
A Pilot Feasibility Study of Yttrium-90 Liver Radioembolization Followed by Durvalumab and Tremelimumab in Patients with Microsatellite Stable Colorectal Cancer Liver Metastases.
Chongkai Wang, John Park, +12 authors, Marwan Fakih.
Oncologist, 2019 Dec 21; 25(5). PMID: 31857446    Free PMC article.
Head and Neck Cancer Immunotherapy beyond the Checkpoint Blockade.
B R Heath, N L Michmerhuizen, +4 authors, Y L Lei.
J Dent Res, 2019 Jul 26; 98(10). PMID: 31340724    Free PMC article.
Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death.
Zahra Asadzadeh, Elham Safarzadeh, +7 authors, Behzad Baradaran.
Cancers (Basel), 2020 Apr 29; 12(4). PMID: 32340275    Free PMC article.
RADIANCE - Radiochemotherapy with or without Durvalumab in the treatment of anal squamous cell carcinoma: A randomized multicenter phase II trial.
Daniel Martin, Panagiotis Balermpas, +20 authors, Emmanouil Fokas.
Clin Transl Radiat Oncol, 2020 May 19; 23. PMID: 32420463    Free PMC article.
The abscopal effect 67 years later: from a side story to center stage.
Sandra Demaria, Silvia C Formenti.
Br J Radiol, 2020 Feb 27; 93(1109). PMID: 32101479    Free PMC article.
Soluble CD80 Protein Delays Tumor Growth and Promotes Tumor-Infiltrating Lymphocytes.
Lucas A Horn, Tiha M Long, +2 authors, Suzanne Ostrand-Rosenberg.
Cancer Immunol Res, 2017 Nov 11; 6(1). PMID: 29122838    Free PMC article.
Radiation Exposure-Induced Changes in the Immune Cells and Immune Factors of Mice With or Without Primary Lung Tumor.
Shuxian Pan, Jingjie Wang, +11 authors, Wentao Hu.
Dose Response, 2020 Jun 04; 18(2). PMID: 32489339    Free PMC article.
Increased effect of two-fraction radiotherapy in conjunction with IDO1 inhibition in experimental glioblastoma.
Jonatan Ahlstedt, Elise Konradsson, Crister Ceberg, Henrietta Nittby Redebrandt.
PLoS One, 2020 May 30; 15(5). PMID: 32469935    Free PMC article.
Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28.
F R Mariotti, L Quatrini, +5 authors, L Moretta.
Br J Pharmacol, 2020 Apr 27; 177(13). PMID: 32335915    Free PMC article.
ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma.
Hailong Sheng, Yan Huang, +10 authors, Chuanhui Cao.
J Immunother Cancer, 2020 May 29; 8(1). PMID: 32461345    Free PMC article.
A review of radiation-induced lymphopenia in patients with esophageal cancer: an immunological perspective for radiotherapy.
Xin Wang, Peiliang Wang, +3 authors, Minghuan Li.
Ther Adv Med Oncol, 2020 Jun 11; 12. PMID: 32518598    Free PMC article.
Anti-PD-L1 (atezolizumab) as an immune primer and concurrently with extended-field chemoradiotherapy for node-positive locally advanced cervical cancer.
Jyoti Mayadev, Dmitriy Zamarin, +4 authors, Russell Schilder.
Int J Gynecol Cancer, 2019 Dec 25; 30(5). PMID: 31871115    Free PMC article.
Immune Checkpoint Inhibitors in Hepatocellular Cancer: Current Understanding on Mechanisms of Resistance and Biomarkers of Response to Treatment.
Amblessed E Onuma, Hongji Zhang, +3 authors, Allan Tsung.
Gene Expr, 2020 Apr 29; 20(1). PMID: 32340652    Free PMC article.
Combination treatment with radiotherapy and a novel oxidative phosphorylation inhibitor overcomes PD-1 resistance and enhances antitumor immunity.
Dawei Chen, Hampartsoum B Barsoumian, +11 authors, James Welsh.
J Immunother Cancer, 2020 Jun 26; 8(1). PMID: 32581056    Free PMC article.
Immunomodulation of NK Cells by Ionizing Radiation.
Jiarui Chen, Xingyu Liu, +7 authors, Conghua Xie.
Front Oncol, 2020 Jul 03; 10. PMID: 32612950    Free PMC article.
The impact of immunotherapy on the survival of pancreatic adenocarcinoma patients who do not receive definitive surgery of the tumor.
Saber Amin, Michael Baine, +2 authors, Chi Lin.
Clin Transl Radiat Oncol, 2020 Jul 03; 24. PMID: 32613090    Free PMC article.
Radiotherapy-immunotherapy combinations - perspectives and challenges.
Michele Mondini, Antonin Levy, +2 authors, Eric Deutsch.
Mol Oncol, 2020 Mar 01; 14(7). PMID: 32112478    Free PMC article.
Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non-Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial.
Willemijn S M E Theelen, Heike M U Peulen, +9 authors, Paul Baas.
JAMA Oncol, 2019 Jul 12; 5(9). PMID: 31294749    Free PMC article.
Highly Cited.
Low Lymphocyte Count Is Associated With Radiotherapy Parameters and Affects the Outcomes of Esophageal Squamous Cell Carcinoma Patients.
Xin Wang, Zongxing Zhao, +3 authors, Minghuan Li.
Front Oncol, 2020 Jul 14; 10. PMID: 32656085    Free PMC article.
Chemoradioimmunotherapy of inoperable stage III non-small cell lung cancer: immunological rationale and current clinical trials establishing a novel multimodal strategy.
Lukas Käsmann, Chukwuka Eze, +6 authors, Farkhad Manapov.
Radiat Oncol, 2020 Jul 11; 15(1). PMID: 32646443    Free PMC article.
Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.
Steven F Powell, Kathryn A Gold, +15 authors, William C Spanos.
J Clin Oncol, 2020 Jun 02; 38(21). PMID: 32479189    Free PMC article.
Radiation Dose Escalation is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma.
Wataru Takenaka, Yutaka Takahashi, +6 authors, Kazuhiko Ogawa.
Cancers (Basel), 2020 Jun 18; 12(6). PMID: 32545427    Free PMC article.
Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer.
Kenji Fujiwara, May Tun Saung, +15 authors, Lei Zheng.
J Immunother Cancer, 2020 Jul 18; 8(2). PMID: 32675194    Free PMC article.
Immune Checkpoint Inhibitors and Radiotherapy in NSCLC Patients: Not Just a Fluke.
Lorenzo Belluomini, Francesco Fiorica, Antonio Frassoldati.
Oncol Ther, 2020 Jul 24; 7(1). PMID: 32700194    Free PMC article.
SBRT combined with PD-1/PD-L1 inhibitors in NSCLC treatment: a focus on the mechanisms, advances, and future challenges.
Yu Chen, Min Gao, +2 authors, Xiangjiao Meng.
J Hematol Oncol, 2020 Jul 30; 13(1). PMID: 32723363    Free PMC article.
Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival.
Koki Nakashima, Yoshiki Demura, +5 authors, Tamotsu Ishizuka.
Intern Med, 2020 Mar 13; 59(11). PMID: 32161221    Free PMC article.
Significant benefits of pembrolizumab in treating refractory advanced pulmonary sarcomatoid carcinoma: A case report.
Ping Chen, Min Yu, +5 authors, Shuang Zhang.
World J Clin Cases, 2020 Aug 04; 8(13). PMID: 32742998    Free PMC article.
Cost-effectiveness analysis of salvage therapies in locoregional previously irradiated head and neck cancer.
HaYeon Kim, John A Vargo, +6 authors, Kenneth J Smith.
Head Neck, 2018 Mar 15; 40(8). PMID: 29537684    Free PMC article.
A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer.
John A Vargo, Matthew C Ward, +21 authors, Dwight E Heron.
Int J Radiat Oncol Biol Phys, 2017 Sep 14; 100(3). PMID: 28899556    Free PMC article.
Severe thromboembolic phenomenon in the setting of pseudoprogression of melanoma brain metastases in response to combination immunotherapy.
Matthew C Perez, Hsiang-Hsuan M Yu, Joseph Markowitz.
BMJ Case Rep, 2018 Aug 16; 2018. PMID: 30108120    Free PMC article.
Association of tumour and stroma PD-1, PD-L1, CD3, CD4 and CD8 expression with DCB and OS to nivolumab treatment in NSCLC patients pre-treated with chemotherapy.
Anna-Larissa Nadia Niemeijer, Sara Sahba, +3 authors, Erik Thunnissen.
Br J Cancer, 2020 May 21; 123(3). PMID: 32433601    Free PMC article.
Molecular Mechanisms and Potential Therapeutic Reversal of Pancreatic Cancer-Induced Immune Evasion.
Li-Lian Gan, Ling-Wei Hii, +2 authors, Chun-Wai Mai.
Cancers (Basel), 2020 Jul 16; 12(7). PMID: 32664564    Free PMC article.
Modulation of Determinant Factors to Improve Therapeutic Combinations with Immune Checkpoint Inhibitors.
Magalie Dosset, Elodie Lauret-Marie Joseph, Thaiz Rivera Vargas, Lionel Apetoh.
Cells, 2020 Jul 28; 9(7). PMID: 32707692    Free PMC article.
An Immunophenotyping of Ovarian Cancer With Clinical and Immunological Significance.
Kai Yang, Weiwei Zhao, +7 authors, Kang Li.
Front Immunol, 2018 Apr 10; 9. PMID: 32793247    Free PMC article.
Old dogs, new trick: classic cancer therapies activate cGAS.
Seoyun Yum, Minghao Li, Zhijian J Chen.
Cell Res, 2020 Jun 17; 30(8). PMID: 32541866    Free PMC article.
Research Progress and Existing Problems for Abscopal Effect.
Di Wang, Xia Zhang, +6 authors, Jinming Yu.
Cancer Manag Res, 2020 Aug 18; 12. PMID: 32801902    Free PMC article.
Immune checkpoint inhibitor combination therapy for gastric cancer: Research progress.
Xiaoxu Song, Weiwei Qi, +6 authors, Jing Lv.
Oncol Lett, 2020 Aug 18; 20(4). PMID: 32802168    Free PMC article.
Immune Checkpoint Imaging in Oncology: A Game Changer Toward Personalized Immunotherapy?
Susanne Lütje, Georg Feldmann, +2 authors, Ralph A Bundschuh.
J Nucl Med, 2020 Jan 12; 61(8). PMID: 31924724    Free PMC article.
The Promise of Combining Radiation Therapy With Immunotherapy.
Justin C Jagodinsky, Paul M Harari, Zachary S Morris.
Int J Radiat Oncol Biol Phys, 2020 Apr 27; 108(1). PMID: 32335187    Free PMC article.
Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer.
Victoria Stary, Brigitte Wolf, +8 authors, Michael Bergmann.
J Immunother Cancer, 2020 Aug 21; 8(2). PMID: 32817359    Free PMC article.
Ultrathin metal-organic layer-mediated radiotherapy-radiodynamic therapy enhances immunotherapy of metastatic cancers.
Kaiyuan Ni, Guangxu Lan, +5 authors, Wenbin Lin.
Matter, 2020 Aug 25; 1(5). PMID: 32832885    Free PMC article.
Immune checkpoint blockade in solid organ tumours: Choice, dose and predictors of response.
Vishal Navani, Moira C Graves, Nikola A Bowden, Andre Van Der Westhuizen.
Br J Clin Pharmacol, 2020 May 10; 86(9). PMID: 32384184    Free PMC article.
Short-course radiation followed by mFOLFOX-6 plus avelumab for locally-advanced rectal adenocarcinoma.
Ali Shamseddine, Youssef H Zeidan, +22 authors, Fady Geara.
BMC Cancer, 2020 Sep 03; 20(1). PMID: 32873251    Free PMC article.
Immune Checkpoint Inhibitors in pMMR Metastatic Colorectal Cancer: A Tough Challenge.
Federica Marmorino, Alessandra Boccaccino, +2 authors, Chiara Cremolini.
Cancers (Basel), 2020 Aug 23; 12(8). PMID: 32824490    Free PMC article.
Combinatorial approach to cancer immunotherapy: strength in numbers.
Anna E Vilgelm, Douglas B Johnson, Ann Richmond.
J Leukoc Biol, 2016 Jun 04; 100(2). PMID: 27256570    Free PMC article.
Clinical Response to Anti-Programmed Death 1 After Response and Subsequent Progression on Anti-Programmed Death Ligand 1 Therapy.
Emily H Castellanos, Emily Feld, +5 authors, Leora Horn.
JCO Precis Oncol, 2017 Aug 15; 1. PMID: 32913978    Free PMC article.
Applying Precision Oncology Principles in Radiation Oncology.
Sophia C Kamran, Kent W Mouw.
JCO Precis Oncol, 2018 May 14; 2. PMID: 32914000    Free PMC article.
A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice.
Nadja Salomon, Fulvia Vascotto, +9 authors, Sebastian Kreiter.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923128    Free PMC article.
Long-Lasting Response to Nivolumab for a Patient With Lynch Syndrome-Associated Lung Adenocarcinoma.
Keita Masuzawa, Takanori Asakura, +8 authors, Kenzo Soejima.
JCO Precis Oncol, 2020 Sep 15; 4. PMID: 32923879    Free PMC article.
Advances in immunotherapy for stage III non-small cell lung cancer: moving immune checkpoint inhibitors to the front lines concurrently with chemoradiotherapy?
Toyoaki Hida, Teppei Yamaguchi.
J Thorac Dis, 2020 Sep 19; 12(8). PMID: 32944372    Free PMC article.
Radium-223 mechanism of action: implications for use in treatment combinations.
Michael J Morris, Eva Corey, +5 authors, George Sgouros.
Nat Rev Urol, 2019 Nov 13; 16(12). PMID: 31712765    Free PMC article.
Checkpoint Inhibition: Will Combination with Radiotherapy and Nanoparticle-Mediated Delivery Improve Efficacy?
Purushottam Lamichhane, Neha P Amin, Manuj Agarwal, Narottam Lamichhane.
Medicines (Basel), 2018 Oct 27; 5(4). PMID: 30360504    Free PMC article.
Radiotherapy as a New Player in Immuno-Oncology.
Shang-Jui Wang, Bruce Haffty.
Cancers (Basel), 2018 Dec 19; 10(12). PMID: 30558196    Free PMC article.
Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma.
Adriana Blakaj, Stacey M Stein, Sajid A Khan, Kimberly L Johung.
J Gastrointest Oncol, 2019 Jan 04; 9(6). PMID: 30603121    Free PMC article.
Evaluation of combined anti-PD-1 immunotherapy and radiation therapy in a preclinical mouse model of pneumonitis and fibrosis.
Derek Nichols, Theresa A Boyle, +6 authors, Bradford A Perez.
J Thorac Dis, 2019 Jan 10; 10(11). PMID: 30622798    Free PMC article.
Combining stereotactic body radiation therapy with immunotherapy: current data and future directions.
Alexander J Lin, Michael Roach, Jeffrey Bradley, Clifford Robinson.
Transl Lung Cancer Res, 2019 Feb 23; 8(1). PMID: 30788240    Free PMC article.
Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System.
Shweta Joshi, Donald L Durden.
J Oncol, 2019 Mar 12; 2019. PMID: 30853982    Free PMC article.
Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma.
Karishma R Rajani, Lucas P Carlstrom, +3 authors, Terry C Burns.
Front Oncol, 2019 Mar 12; 8. PMID: 30854331    Free PMC article.
Compound-therapy based on cancer-immunity cycle: promising prospects for antitumor regimens.
Dong Gao.
Am J Cancer Res, 2019 Mar 25; 9(2). PMID: 30906623    Free PMC article.
Efficacy of immunotherapy in sarcomatoid lung cancer, a case report and literature review.
Magda Palka Kotlowska, Ana Gómez Rueda, +6 authors, Pilar Garrido López.
Respir Med Case Rep, 2019 Apr 02; 26. PMID: 30931249    Free PMC article.
Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy.
Maxim Shevtsov, Hiro Sato, Gabriele Multhoff, Atsushi Shibata.
Front Oncol, 2019 Apr 04; 9. PMID: 30941308    Free PMC article.
Radiotherapy Both Promotes and Inhibits Myeloid-Derived Suppressor Cell Function: Novel Strategies for Preventing the Tumor-Protective Effects of Radiotherapy.
Suzanne Ostrand-Rosenberg, Lucas A Horn, Nicholas G Ciavattone.
Front Oncol, 2019 Apr 20; 9. PMID: 31001479    Free PMC article.
The rationale for including immune checkpoint inhibition into multimodal primary treatment concepts of head and neck cancer.
Ingeborg Tinhofer, Volker Budach, Korinna Jöhrens, Ulrich Keilholz.
Cancers Head Neck, 2016 Aug 10; 1. PMID: 31093338    Free PMC article.
Induction of the Abscopal Effect with Immunotherapy and Palliative Radiation in Metastatic Head and Neck Squamous Cell Carcinoma: A Case Report and Review of the Literature.
Ashwin Shinde, Jennifer Novak, +2 authors, Arya Amini.
Cureus, 2019 May 23; 11(3). PMID: 31114720    Free PMC article.
The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary Liver Tumors.
Malek Kreidieh, Youssef H Zeidan, Ali Shamseddine.
J Oncol, 2019 Jun 12; 2019. PMID: 31182960    Free PMC article.
The 6th R of Radiobiology: Reactivation of Anti-Tumor Immune Response.
Jihane Boustani, Mathieu Grapin, +2 authors, Céline Mirjolet.
Cancers (Basel), 2019 Jun 23; 11(6). PMID: 31226866    Free PMC article.
Is the Blood an Alternative for Programmed Cell Death Ligand 1 Assessment in Non-Small Cell Lung Cancer?
Emmanuel Acheampong, Isaac Spencer, +3 authors, Elin Gray.
Cancers (Basel), 2019 Jul 03; 11(7). PMID: 31262041    Free PMC article.
Gut Microbiota Shapes the Efficiency of Cancer Therapy.
Weidong Ma, Qixing Mao, +3 authors, Feng Jiang.
Front Microbiol, 2019 Jul 12; 10. PMID: 31293523    Free PMC article.
Highly Cited. Review.
Emerging and Novel Treatments for Pituitary Tumors.
Mirela Diana Ilie, Hélène Lasolle, Gérald Raverot.
J Clin Med, 2019 Jul 28; 8(8). PMID: 31349718    Free PMC article.
Clinical and radiation dose-volume factors related to pneumonitis after treatment with radiation and durvalumab in locally advanced non-small cell lung cancer.
Hiroto Inoue, Akira Ono, +14 authors, Toshiaki Takahashi.
Invest New Drugs, 2020 Mar 05; 38(5). PMID: 32128667    Free PMC article.
Immunotherapy in urothelial cancer, part 2: adjuvant, neoadjuvant, and adjunctive treatment.
Steven S Yu, Leslie K Ballas, +3 authors, David I Quinn.
Clin Adv Hematol Oncol, 2017 Jul 28; 15(7). PMID: 28749918    Free PMC article.
[Interleukin-12 over-expression in malignant melanoma B16 cells reduces programmed death-1 expression on T cells in mice with immune reconstitution].
Yanyouhong Liu, Hongling Xu, +2 authors, Shijun Kang.
Nan Fang Yi Ke Da Xue Xue Bao, 2020 Sep 09; 40(6). PMID: 32895201    Free PMC article.
Persistent anti-NY-ESO-1-specific T cells and expression of differential biomarkers in a patient with metastatic gastric cancer benefiting from combined radioimmunotherapy treatment: a case report.
Maysaloun Merhi, Afsheen Raza, +15 authors, Said Dermime.
J Immunother Cancer, 2020 Sep 12; 8(2). PMID: 32913031    Free PMC article.
Combined radiotherapy and immunotherapy in urothelial bladder cancer: harnessing the full potential of the anti-tumor immune response.
Mame Daro-Faye, Wassim Kassouf, +4 authors, Paul Sargos.
World J Urol, 2020 Sep 12; 39(5). PMID: 32915313    Free PMC article.
Radiation recall pneumonitis induced by PD-1/PD-L1 blockades: mechanisms and therapeutic implications.
Feifei Teng, Min Li, Jinming Yu.
BMC Med, 2020 Sep 19; 18(1). PMID: 32943072    Free PMC article.
Expression and clinical significance of PD-L1, B7-H3, B7-H4 and VISTA in craniopharyngioma.
Yuelong Wang, Jiaojiao Deng, +10 authors, Jianguo Xu.
J Immunother Cancer, 2020 Sep 23; 8(2). PMID: 32958683    Free PMC article.
CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy.
Hongfei Wang, Yixuan Sun, +11 authors, Yanfeng Gao.
J Immunother Cancer, 2020 Oct 07; 8(2). PMID: 33020240    Free PMC article.
Retrospective analysis of safety and efficacy of anti-PD-1 therapy and radiation therapy in advanced melanoma: A bi-institutional study.
Yvonne M Mowery, Kirtesh Patel, +9 authors, April K S Salama.
Radiother Oncol, 2019 Jun 30; 138. PMID: 31252292    Free PMC article.
Hepatocellular Carcinoma-The Influence of Immunoanatomy and the Role of Immunotherapy.
Keyur Patel, Ryan Lamm, +2 authors, Ashesh P Shah.
Int J Mol Sci, 2020 Sep 19; 21(18). PMID: 32942580    Free PMC article.
Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models.
Marit van Elsas, Jan Willem Kleinovink, +8 authors, Sjoerd H van der Burg.
J Immunother Cancer, 2020 Oct 02; 8(2). PMID: 32998952    Free PMC article.
B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer.
Yanchao Ma, Shenghua Zhan, +7 authors, Weichang Chen.
Cell Death Dis, 2020 Oct 05; 11(10). PMID: 33011740    Free PMC article.
Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy.
Zachary S Buchwald, Tahseen H Nasti, +7 authors, Mohammad K Khan.
J Immunother Cancer, 2020 Oct 09; 8(2). PMID: 33028691    Free PMC article.
Application and Prospects of Molecular Imaging in Immunotherapy.
Weiqing Wang, Zhenhua Gao, +4 authors, Xue Meng.
Cancer Manag Res, 2020 Oct 17; 12. PMID: 33061627    Free PMC article.
Inhibition of Immunosuppressive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking.
Lian Li, Yachao Li, +5 authors, Jiyuan Yang.
Adv Funct Mater, 2020 Oct 20; 30(12). PMID: 33071706    Free PMC article.
A Tumor-Immune Interaction Model for Synergistic Combinations of Anti PD-L1 and Ionizing Irradiation Treatment.
Jong Hyuk Byun, In-Soo Yoon, +2 authors, Il Hyo Jung.
Pharmaceutics, 2020 Sep 04; 12(9). PMID: 32878065    Free PMC article.
Immunotherapy in Corticotroph and Lactotroph Aggressive Tumors and Carcinomas: Two Case Reports and a Review of the Literature.
Camille Duhamel, Mirela Diana Ilie, +7 authors, Gérald Raverot.
J Pers Med, 2020 Aug 23; 10(3). PMID: 32823651    Free PMC article.
Addition of Radiotherapy to Immunotherapy: Effects on Outcome of Different Subgroups Using a Propensity Score Matching.
Maike Trommer, Jaika Kinsky, +12 authors, Christian Baues.
Cancers (Basel), 2020 Sep 02; 12(9). PMID: 32867046    Free PMC article.
Targeting Myeloid-Derived Suppressor Cells in Cancer Immunotherapy.
Yufei Wang, Anna Jia, +5 authors, Guangwei Liu.
Cancers (Basel), 2020 Sep 19; 12(9). PMID: 32942545    Free PMC article.
Intra-hepatic Abscopal Effect Following Radioembolization of Hepatic Metastases.
Maciej Powerski, Ralph Drewes, +3 authors, Maciej Pech.
Cardiovasc Intervent Radiol, 2020 Aug 19; 43(11). PMID: 32808201    Free PMC article.
Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer.
Fang-Fei Qian, Bao-Hui Han.
Chin Med J (Engl), 2020 Sep 25; 133(20). PMID: 32969861    Free PMC article.
Combinational Immunotherapy for Hepatocellular Carcinoma: Radiotherapy, Immune Checkpoint Blockade and Beyond.
Yun Hua Lee, David Tai, +2 authors, Valerie Chew.
Front Immunol, 2020 Oct 30; 11. PMID: 33117354    Free PMC article.
Radiotherapy-Mediated Immunomodulation and Anti-Tumor Abscopal Effect Combining Immune Checkpoint Blockade.
Xinrui Zhao, Chunlin Shao.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992835    Free PMC article.
Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer.
Charles M Haughey, Debayan Mukherjee, +14 authors, Sharon L Eddie.
Cancers (Basel), 2020 Oct 03; 12(10). PMID: 33003551    Free PMC article.
Tumor Microenvironment as a Regulator of Radiation Therapy: New Insights into Stromal-Mediated Radioresistance.
Varintra E Krisnawan, Jennifer A Stanley, Julie K Schwarz, David G DeNardo.
Cancers (Basel), 2020 Oct 15; 12(10). PMID: 33050580    Free PMC article.
Combining radiotherapy and immunotherapy in definitive treatment of head and neck squamous cell carcinoma: review of current clinical trials.
Gaber Plavc, Primoz Strojan.
Radiol Oncol, 2020 Oct 17; 54(4). PMID: 33064670    Free PMC article.
Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929).
Diane M Da Silva, Danielle M Enserro, +10 authors, W Martin Kast.
Clin Cancer Res, 2020 Aug 21; 26(21). PMID: 32816895    Free PMC article.
Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade.
Karsten A Pilones, Michal Hensler, +5 authors, Silvia C Formenti.
Oncoimmunology, 2020 Nov 06; 9(1). PMID: 33150045    Free PMC article.
Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists.
Alice Y Ho, Jean L Wright, +19 authors, Gaorav P Gupta.
Int J Radiat Oncol Biol Phys, 2020 May 18; 108(1). PMID: 32417409    Free PMC article.
Reprogramming the tumour microenvironment by radiotherapy: implications for radiotherapy and immunotherapy combinations.
Madyson Colton, Eleanor J Cheadle, Jamie Honeychurch, Tim M Illidge.
Radiat Oncol, 2020 Nov 06; 15(1). PMID: 33148287    Free PMC article.
Role of GLUT-1 in the Upregulation of PD-L1 Expression After Radiotherapy and Association of PD-L1 with Favourable Overall Survival in Hypopharyngeal Cancer.
Li-Fang Shen, Shui-Hong Zhou, Yu Guo.
Onco Targets Ther, 2020 Nov 12; 13. PMID: 33173312    Free PMC article.
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies.
Kaijian Zhou, Shu Guo, +2 authors, Guoxin Liang.
Front Cell Dev Biol, 2020 Nov 13; 8. PMID: 33178688    Free PMC article.
Immunomodulatory Effects of Radiotherapy.
Sharda Kumari, Shibani Mukherjee, +3 authors, Aroumougame Asaithamby.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33142765    Free PMC article.
The Resistance Mechanisms of Lung Cancer Immunotherapy.
Fen Wang, Shubin Wang, Qing Zhou.
Front Oncol, 2020 Nov 17; 10. PMID: 33194652    Free PMC article.
Eliminating Radiation Resistance of Non-Small Cell Lung Cancer by Dihydroartemisinin Through Abrogating Immunity Escaping and Promoting Radiation Sensitivity by Inhibiting PD-L1 Expression.
Hai Zhang, Fei Zhou, +8 authors, Xiaomei Gong.
Front Oncol, 2020 Nov 17; 10. PMID: 33194761    Free PMC article.
A narrative review of synergistic drug administration in unresectable locally advanced non-small cell lung cancer: current landscape and future prospects in the era of immunotherapy.
Shuyan Li, Xiao Chu, +2 authors, Zhengfei Zhu.
Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209628    Free PMC article.
Radiotherapy for non-small cell lung cancer in the immunotherapy era: the opportunity and challenge-a narrative review.
Wu-Yan Xia, Wen Feng, +5 authors, Xiao-Long Fu.
Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209631    Free PMC article.
Moving Forward in Cervical Cancer: Enhancing Susceptibility to DNA Repair Inhibition and Damage, an NCI Clinical Trials Planning Meeting Report.
Matthew M Harkenrider, Merry Jennifer Markham, +5 authors, Elise C Kohn.
J Natl Cancer Inst, 2020 Mar 29; 112(11). PMID: 32219419    Free PMC article.
KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression.
Xiao Albert Zhou, Jiadong Zhou, +13 authors, Jiadong Wang.
Proc Natl Acad Sci U S A, 2020 Oct 29; 117(45). PMID: 33109719    Free PMC article.
The Mechanisms of PD-L1 Regulation in Non-Small-Cell Lung Cancer (NSCLC): Which Are the Involved Players?
Giuseppe Lamberti, Monia Sisi, +5 authors, Francesco Gelsomino.
Cancers (Basel), 2020 Oct 30; 12(11). PMID: 33114576    Free PMC article.
Challenges in Combining Immunotherapy with Radiotherapy in Recurrent/Metastatic Head and Neck Cancer.
Gaber Plavc, Tanja Jesenko, Miha Oražem, Primož Strojan.
Cancers (Basel), 2020 Nov 05; 12(11). PMID: 33143094    Free PMC article.
Immunotherapy Moves to the Early-Stage Setting in Non-Small Cell Lung Cancer: Emerging Evidence and the Role of Biomarkers.
Xabier Mielgo-Rubio, Virginia Calvo, +11 authors, Felipe Couñago.
Cancers (Basel), 2020 Nov 26; 12(11). PMID: 33233705    Free PMC article.
Recent Advances in the Clinical Development of Immune Checkpoint Blockade Therapy for Mismatch Repair Proficient (pMMR)/non-MSI-H Metastatic Colorectal Cancer.
James J Lee, Edward Chu.
Clin Colorectal Cancer, 2018 Aug 04; 17(4). PMID: 30072278    Free PMC article.
A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing.
Patrick H Lizotte, Ruey-Long Hong, +16 authors, Pasi A Jänne.
Cancer Immunol Res, 2018 Sep 23; 6(12). PMID: 30242021    Free PMC article.
Combining PARP inhibition, radiation, and immunotherapy: A possible strategy to improve the treatment of cancer?
Mathieu Césaire, Juliette Thariat, +3 authors, François Chevalier.
Int J Mol Sci, 2018 Nov 30; 19(12). PMID: 30487462    Free PMC article.
Immune checkpoint blockade for Merkel cell carcinoma: actual findings and unanswered questions.
Marco Gallo, Valentina Guarnotta, +4 authors, NIKE Group.
J Cancer Res Clin Oncol, 2019 Jan 09; 145(2). PMID: 30617553
Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma.
Houda Bahig, Francine Aubin, +14 authors, Philip Wong.
BMC Cancer, 2019 Jan 16; 19(1). PMID: 30642290    Free PMC article.
Time for radioimmunotherapy: an overview to bring improvements in clinical practice.
O Leaman Alcibar, D Candini, +9 authors, M E Rodríguez-Ruiz.
Clin Transl Oncol, 2019 Jan 16; 21(8). PMID: 30644044
Overall survival according to immunotherapy and radiation treatment for metastatic non-small-cell lung cancer: a National Cancer Database analysis.
Corey C Foster, David J Sher, +4 authors, Matthew Koshy.
Radiat Oncol, 2019 Jan 30; 14(1). PMID: 30691492    Free PMC article.
Increased PD-L1 expression in radioresistant HNSCC cell lines after irradiation affects cell proliferation due to inactivation of GSK-3beta.
Daniela Schulz, Irene Stancev, +7 authors, Tobias Ettl.
Oncotarget, 2019 Feb 08; 10(5). PMID: 30728908    Free PMC article.
Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment.
Chin-King Looi, Felicia Fei-Lei Chung, +3 authors, Chun-Wai Mai.
J Exp Clin Cancer Res, 2019 Apr 17; 38(1). PMID: 30987642    Free PMC article.
Highly Cited. Review.
Stereotactic Ablative Radiotherapy Combined with Immune Checkpoint Inhibitors Reboots the Immune Response Assisted by Immunotherapy in Metastatic Lung Cancer: A Systematic Review.
Rodolfo Chicas-Sett, Ignacio Morales-Orue, +5 authors, Pedro C Lara.
Int J Mol Sci, 2019 May 06; 20(9). PMID: 31052488    Free PMC article.
Systematic Review.
Sustained partial remission of a metastatic NEN using off-label immunotherapy with pembrolizumab.
Anna Kathrin Stüven, Bertram Wiedenmann.
Oncotarget, 2019 May 31; 10(35). PMID: 31143376    Free PMC article.
Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma.
Changhoon Choi, Gyu Sang Yoo, Won Kyung Cho, Hee Chul Park.
World J Gastroenterol, 2019 Jun 07; 25(20). PMID: 31171886    Free PMC article.
Advances in engineering local drug delivery systems for cancer immunotherapy.
Peter Abdou, Zejun Wang, +4 authors, Zhen Gu.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020 Apr 08; 12(5). PMID: 32255276    Free PMC article.
[Immunotherapy Advances in Small Cell Lung Cancer].
Yangyang Xu, Ping Zhan, Yong Song.
Zhongguo Fei Ai Za Zhi, 2020 Aug 06; 23(11). PMID: 32752583    Free PMC article.
Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines.
Laura Hartmann, Philipp Schröter, +8 authors, Stefan B Eichmüller.
Sci Rep, 2020 Dec 11; 10(1). PMID: 33299018    Free PMC article.
Immunostimulatory Effects of Radiotherapy for Local and Systemic Control of Melanoma: A Review.
Junko Takahashi, Shinsuke Nagasawa.
Int J Mol Sci, 2020 Dec 11; 21(23). PMID: 33297519    Free PMC article.
Rationale for concurrent chemoradiotherapy for patients with stage III non-small-cell lung cancer.
John Conibear, AstraZeneca UK Limited.
Br J Cancer, 2020 Dec 10; 123(Suppl 1). PMID: 33293671    Free PMC article.
Beyond chemoradiotherapy: improving treatment outcomes for patients with stage III unresectable non-small-cell lung cancer through immuno-oncology and durvalumab (Imfinzi®▼, AstraZeneca UK Limited).
Priyanka Patel, Doraid Alrifai, +2 authors, AstraZeneca UK Limited.
Br J Cancer, 2020 Dec 10; 123(Suppl 1). PMID: 33293672    Free PMC article.
The future of personalised radiotherapy for head and neck cancer.
Jimmy J Caudell, Javier F Torres-Roca, +5 authors, Louis B Harrison.
Lancet Oncol, 2017 May 01; 18(5). PMID: 28456586    Free PMC article.
Efficacy of Local Treatments for Hepatocellular Carcinoma Involving the Inferior Vena Cava and/or Right Atrium.
Han Ah Lee, Chai Hong Rim.
J Hepatocell Carcinoma, 2020 Dec 31; 7. PMID: 33376712    Free PMC article.
Toward precision immunotherapy using multiplex immunohistochemistry and in silico methods to define the tumor immune microenvironment.
Samuel S Widodo, Ryan A Hutchinson, +8 authors, Theo Mantamadiotis.
Cancer Immunol Immunother, 2021 Jan 04; 70(7). PMID: 33389014
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Jiali Yu, Michael D Green, +37 authors, Weiping Zou.
Nat Med, 2021 Jan 06; 27(1). PMID: 33398162    Free PMC article.
Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer.
Jing Chen, Hong-Wei Sun, +8 authors, Limin Zheng.
Signal Transduct Target Ther, 2021 Jan 09; 6(1). PMID: 33414378    Free PMC article.
Durvalumab and tremelimumab with or without stereotactic body radiation therapy in relapsed small cell lung cancer: a randomized phase II study.
Suchita Pakkala, Kristin Higgins, +14 authors, Taofeek K Owonikoko.
J Immunother Cancer, 2021 Jan 12; 8(2). PMID: 33428583    Free PMC article.
The promising role of radiotherapy in the treatment of advanced or metastatic renal cell carcinoma: a narrative review.
Qinghong Wei, Hongmei He, +2 authors, Weibing Sun.
Transl Androl Urol, 2021 Jan 19; 9(6). PMID: 33457253    Free PMC article.
Optimal combination treatment regimens of vaccine and radiotherapy augment tumor-bearing host immunity.
Fayun Zhang, Zifeng Zheng, +8 authors, Wei Liang.
Commun Biol, 2021 Jan 21; 4(1). PMID: 33469123    Free PMC article.
A narrative review of evolving roles of radiotherapy in advanced non-small cell lung cancer: from palliative care to active player.
Yue Zhou, Fan Yu, +9 authors, Jianjiao Ni.
Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489808    Free PMC article.
A phase I/II study of stereotactic radiotherapy and pembrolizumab for oligometastatic renal tumours (RAPPORT): Clinical trial protocol.
David Pryor, Mathias Bressel, +16 authors, Shankar Siva.
Contemp Clin Trials Commun, 2021 Jan 26; 21. PMID: 33490707    Free PMC article.
3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity.
Lijun Li, Renxiang Chen, +3 authors, Heng-Hong Li.
Adv Radiat Oncol, 2021 Jan 26; 6(1). PMID: 33490731    Free PMC article.
Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy.
Xiaopin Duan, Christina Chan, Wenbin Lin.
Angew Chem Int Ed Engl, 2018 Jul 18; 58(3). PMID: 30016571    Free PMC article.
Combining radiation therapy and immunotherapy for lung cancers: a narrative review.
Chirag Modi, Lyudmyla Berim, +6 authors, Salma K Jabbour.
Shanghai Chest, 2021 Feb 02; 5. PMID: 33521559    Free PMC article.
Radiation-induced eosinophils improve cytotoxic T lymphocyte recruitment and response to immunotherapy.
Jia-Nan Cheng, Wen Luo, +12 authors, Bo Zhu.
Sci Adv, 2021 Jan 31; 7(5). PMID: 33514544    Free PMC article.
Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine.
Chunju Fang, Fei Mo, +7 authors, Xiawei Wei.
Cell Mol Immunol, 2020 May 14; 18(9). PMID: 32398808    Free PMC article.
Radiation and Immunotherapy in Upper Gastrointestinal Cancers: The Current State of Play.
Noel E Donlon, Robert Power, +3 authors, Joanne Lysaght.
Int J Mol Sci, 2021 Jan 28; 22(3). PMID: 33499003    Free PMC article.
Radiotherapy-Immunotherapy Combination: How Will We Bridge the Gap Between Pre-Clinical Promise and Effective Clinical Delivery?
Erminia Romano, Jamie Honeychurch, Timothy M Illidge.
Cancers (Basel), 2021 Feb 04; 13(3). PMID: 33530329    Free PMC article.
X-change symposium: status and future of modern radiation oncology-from technology to biology.
Stefanie Corradini, Maximilian Niyazi, +14 authors, Claus Belka.
Radiat Oncol, 2021 Feb 06; 16(1). PMID: 33541387    Free PMC article.
Targeting autophagy enhances atezolizumab-induced mitochondria-related apoptosis in osteosarcoma.
Zhuochao Liu, Hongyi Wang, +6 authors, Weibin Zhang.
Cell Death Dis, 2021 Feb 10; 12(2). PMID: 33558476    Free PMC article.
Metastatic Melanoma With Leptomeningeal Disease.
Amanda M Marinova, Jennifer L Reilly, +2 authors, Anthony J Olszanski.
J Adv Pract Oncol, 2021 Feb 09; 12(1). PMID: 33552663    Free PMC article.
Discovery of a new inhibitor targeting PD-L1 for cancer immunotherapy.
Fengling Wang, Wenling Ye, +9 authors, Xiaojun Yao.
Neoplasia, 2021 Feb 03; 23(3). PMID: 33529880    Free PMC article.
Hypofractionated Low-Dose Radiotherapy Combined with Immune Checkpoint Inhibition in Metastatic Solid Tumors.
Dongqing Li, Wenyu Zhu, +5 authors, Hua Jiang.
Onco Targets Ther, 2021 Feb 12; 14. PMID: 33568917    Free PMC article.
Surgery after neoadjuvant immunotherapy in patients with resectable non-small cell lung cancer.
Caroline Huynh, Logan A Walsh, Jonathan D Spicer.
Transl Lung Cancer Res, 2021 Feb 12; 10(1). PMID: 33569337    Free PMC article.
Novel Combination Therapies for the Treatment of Bladder Cancer.
Mei Peng, Di Xiao, +4 authors, Xiaoping Yang.
Front Oncol, 2021 Feb 16; 10. PMID: 33585182    Free PMC article.
Immunotherapeutic advances in gastric cancer.
Akira Yoneda, Tamotsu Kuroki, Susumu Eguchi.
Surg Today, 2021 Feb 17; 51(11). PMID: 33590326
Evaluation of antitumor immunity by a combination treatment of high-dose irradiation, anti-PDL1, and anti-angiogenic therapy in murine lung tumors.
Jenny Ling-Yu Chen, Chun-Kai Pan, +5 authors, Ming-Jium Shieh.
Cancer Immunol Immunother, 2020 Aug 08; 70(2). PMID: 32761424
Immune landscape and therapeutic strategies: new insights into PD-L1 in tumors.
Yuan Wei, Xiao Xiao, +2 authors, Dong-Ming Kuang.
Cell Mol Life Sci, 2020 Sep 18; 78(3). PMID: 32940722
Enhance the Immune Checkpoint Inhibitors Efficacy with Radiotherapy Induced Immunogenic Cell Death: A Comprehensive Review and Latest Developments.
Adrien Procureur, Audrey Simonaggio, +2 authors, Yann-Alexandre Vano.
Cancers (Basel), 2021 Feb 12; 13(4). PMID: 33567530    Free PMC article.
Natural Killer Cells and Anti-Cancer Therapies: Reciprocal Effects on Immune Function and Therapeutic Response.
Elisa C Toffoli, Abdolkarim Sheikhi, +6 authors, Tanja D de Gruijl.
Cancers (Basel), 2021 Feb 13; 13(4). PMID: 33572396    Free PMC article.
A Novel Anti-PD-L1 Antibody Exhibits Antitumor Effects on Multiple Myeloma in Murine Models via Antibody-Dependent Cellular Cytotoxicity.
Jae-Hee Ahn, Byung-Hyun Lee, +8 authors, Hyun-Jeong Ko.
Biomol Ther (Seoul), 2020 Nov 04; 29(2). PMID: 33139584    Free PMC article.
Abscopal Effect of Frozen Autograft Reconstruction Combined with an Immune Checkpoint Inhibitor Analyzed Using a Metastatic Bone Tumor Model.
Noritaka Yonezawa, Hideki Murakami, +14 authors, Hiroyuki Tsuchiya.
Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33671258    Free PMC article.
Biology of NSCLC: Interplay between Cancer Cells, Radiation and Tumor Immune Microenvironment.
Slavisa Tubin, Mohammad K Khan, Seema Gupta, Branislav Jeremic.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33673332    Free PMC article.
KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma.
Manish A Shah, Jaafar Bennouna, +12 authors, Peter Enzinger.
Future Oncol, 2021 Feb 04; 17(10). PMID: 33533655    Free PMC article.
Immune Checkpoint Inhibitors for Non-Small-Cell Lung Cancer with Brain Metastasis : The Role of Gamma Knife Radiosurgery.
Min Ho Lee, Kyung-Rae Cho, +10 authors, Jung-Il Lee.
J Korean Neurosurg Soc, 2020 Dec 04; 64(2). PMID: 33267531    Free PMC article.
Macrophages and microglia: the cerberus of glioblastoma.
Alice Buonfiglioli, Dolores Hambardzumyan.
Acta Neuropathol Commun, 2021 Mar 27; 9(1). PMID: 33766119    Free PMC article.
A combination of PD‑1/PD‑L1 inhibitors: The prospect of overcoming the weakness of tumor immunotherapy (Review).
Xianbin Kong, Peng Lu, +8 authors, Jingyan Meng.
Mol Med Rep, 2021 Mar 25; 23(5). PMID: 33760188    Free PMC article.
Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer.
Incheol Seo, Hye Won Lee, +6 authors, Sung Uk Bae.
J Immunother Cancer, 2021 Mar 12; 9(3). PMID: 33692216    Free PMC article.
Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma.
Byung Min Lee, Jinsil Seong.
World J Gastroenterol, 2021 Mar 30; 27(10). PMID: 33776363    Free PMC article.
The role of exosomes in tumour immunity under radiotherapy: eliciting abscopal effects?
Tianwen Yin, Huixian Xin, Jinming Yu, Feifei Teng.
Biomark Res, 2021 Apr 02; 9(1). PMID: 33789758    Free PMC article.
PD-L1 expression in recurrent head and neck squamous cell carcinoma.
Alice Delafoy, Arnaud Uguen, +4 authors, Ulrike Schick.
Eur Arch Otorhinolaryngol, 2021 Apr 03; 279(1). PMID: 33796940
Modeling Radioimmune Response-Current Status and Perspectives.
Thomas Friedrich, Nicholas Henthorn, Marco Durante.
Front Oncol, 2021 Apr 03; 11. PMID: 33796470    Free PMC article.
Impact of Postoperative Radiotherapy on Survival of Patients With de novo Stage IV Breast Cancer: A Population-Based Study From the SEER Database.
Jie Zhang, Shiping Luo, +2 authors, Chuangui Song.
Front Oncol, 2021 Apr 06; 11. PMID: 33816261    Free PMC article.
Survival Benefits of Anti-PD-1 Therapy in Combination With Radiotherapy in Chinese Melanoma Patients With Brain Metastasis.
Shuang Wu, Chuanping Yuan, +4 authors, Lixia Lu.
Front Oncol, 2021 Apr 06; 11. PMID: 33816300    Free PMC article.
Molecular and Clinical Premises for the Combination Therapy Consisting of Radiochemotherapy and Immunotherapy in Non-Small Cell Lung Cancer Patients.
Małgorzata Frąk, Paweł Krawczyk, Ewa Kalinka, Janusz Milanowski.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33799560    Free PMC article.
Improving Anti-PD-1/PD-L1 Therapy for Localized Bladder Cancer.
Florus C de Jong, Vera C Rutten, Tahlita C M Zuiverloon, Dan Theodorescu.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33802033    Free PMC article.
Emerging Trends for Radio-Immunotherapy in Rectal Cancer.
Claudia Corrò, Valérie Dutoit, Thibaud Koessler.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33803620    Free PMC article.
Thinking Small: Small Molecules as Potential Synergistic Adjuncts to Checkpoint Inhibition in Melanoma.
Alexander C Chacon, Alexa D Melucci, Shuyang S Qin, Peter A Prieto.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33810078    Free PMC article.
Avelumab, a PD-L1 Inhibitor, in Combination with Hypofractionated Radiotherapy and the Abscopal Effect in Relapsed Refractory Multiple Myeloma.
Dickran Kazandjian, Alexander Dew, +19 authors, Jennifer C Jones.
Oncologist, 2021 Feb 09; 26(4). PMID: 33554406    Free PMC article.
An inhibitor of programmed death ligand 1 enhances natural killer cell-mediated immunity against malignant melanoma cells.
Young Shin Lee, Woong Heo, +8 authors, Jaeho Bae.
PLoS One, 2021 Apr 02; 16(4). PMID: 33793576    Free PMC article.
Hypofractionated stereotactic re-irradiation with pembrolizumab and bevacizumab in patients with recurrent high-grade gliomas: results from a phase I study.
Solmaz Sahebjam, Peter A Forsyth, +21 authors, Hsiang-Hsuan Michael Yu.
Neuro Oncol, 2020 Nov 12; 23(4). PMID: 33173935    Free PMC article.
Impact of reirradiation, chemotherapy, and immunotherapy on survival of patients with recurrent lung cancer: A single-center retrospective analysis.
Brane Grambozov, Romana Wass, +6 authors, Franz Zehentmayr.
Thorac Cancer, 2021 Feb 16; 12(8). PMID: 33586228    Free PMC article.
Toxicity Profile of Combining PD-1/PD-L1 Inhibitors and Thoracic Radiotherapy in Non-Small Cell Lung Cancer: A Systematic Review.
Butuo Li, Chao Jiang, +5 authors, Linlin Wang.
Front Immunol, 2021 Apr 17; 12. PMID: 33859637    Free PMC article.
Systematic Review.
Optimizing the Treatment Schedule of Radiotherapy Combined With Anti-PD-1/PD-L1 Immunotherapy in Metastatic Cancers.
Yuehong Kong, Yifu Ma, +3 authors, Liyuan Zhang.
Front Oncol, 2021 Apr 17; 11. PMID: 33859942    Free PMC article.
Systematic Review.
Curative-Intent Treatment with Durvalumab in Early-Stage Cancers.
Giovanni Melillo, Vikram Chand, +2 authors, Cristian Massacesi.
Adv Ther, 2021 Apr 22; 38(6). PMID: 33881745    Free PMC article.
Integration of radiotherapy with anti-PD-1 antibody for the treatment of intrahepatic or hilar cholangiocarcinoma: reflection from four cases.
Qianqian Zhao, Yixing Chen, +4 authors, Zhaochong Zeng.
Cancer Biol Ther, 2021 Mar 17; 22(3). PMID: 33722163    Free PMC article.
Complete Pathologic Response After Concurrent Treatment with Pembrolizumab and Radiotherapy in Metastatic Colorectal Cancer: A Case Report.
Jian Yang, Feng Bi, Hongfeng Gou.
Onco Targets Ther, 2021 Apr 22; 14. PMID: 33880034    Free PMC article.
Is immunotherapy in the future of therapeutic management of sarcomas?
Ottavia Clemente, Alessandro Ottaiano, +9 authors, Salvatore Tafuto.
J Transl Med, 2021 Apr 28; 19(1). PMID: 33902630    Free PMC article.
Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?
Sandra Demaria, Chandan Guha, +11 authors, Mansoor M Ahmed.
J Immunother Cancer, 2021 Apr 09; 9(4). PMID: 33827904    Free PMC article.
Immune Modulation Plus Tumor Ablation: Adjuvants and Antibodies to Prime and Boost Anti-Tumor Immunity In Situ.
Renske J E van den Bijgaart, Fabian Schuurmans, +3 authors, Gosse J Adema.
Front Immunol, 2021 May 04; 12. PMID: 33936033    Free PMC article.
Novel Biomarkers of Dynamic Blood PD-L1 Expression for Immune Checkpoint Inhibitors in Advanced Non-Small-Cell Lung Cancer Patients.
Qiao Yang, Mingjing Chen, +11 authors, Jianguo Sun.
Front Immunol, 2021 May 04; 12. PMID: 33936103    Free PMC article.
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Sadna Budhu, Rachel Giese, +13 authors, Taha Merghoub.
Cell Rep, 2021 Jan 14; 34(2). PMID: 33440157    Free PMC article.
Emerging principles of brain immunology and immune checkpoint blockade in brain metastases.
Jawad Fares, Ilya Ulasov, Peter Timashev, Maciej S Lesniak.
Brain, 2021 Apr 25; 144(4). PMID: 33893488    Free PMC article.
Radiotherapy in the Era of Immunotherapy With a Focus on Non-Small-Cell Lung Cancer: Time to Revisit Ancient Dogmas?
Jonathan Khalifa, Julien Mazieres, +2 authors, Elizabeth Cohen-Jonathan Moyal.
Front Oncol, 2021 May 11; 11. PMID: 33968769    Free PMC article.
Interfaces between cellular responses to DNA damage and cancer immunotherapy.
Domenic Pilger, Leonard W Seymour, Stephen P Jackson.
Genes Dev, 2021 Apr 24; 35(9-10). PMID: 33888558    Free PMC article.
Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment.
Chen Chen, Yanlong Liu, Binbin Cui.
Hum Vaccin Immunother, 2021 Jan 12; 17(6). PMID: 33428533    Free PMC article.
Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy.
Justin C Jagodinsky, Won Jong Jin, +21 authors, Zachary S Morris.
Theranostics, 2021 May 18; 11(13). PMID: 33995649    Free PMC article.
STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.
Piyada Sitthideatphaiboon, Ana Galan-Cobo, +14 authors, John V Heymach.
Clin Cancer Res, 2020 Dec 17; 27(6). PMID: 33323404    Free PMC article.
The regulation of immune checkpoints by the hypoxic tumor microenvironment.
Min Hu, Yongfu Li, +5 authors, Hong Zhao.
PeerJ, 2021 May 21; 9. PMID: 34012727    Free PMC article.
Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma.
Rom Leidner, Marka Crittenden, +13 authors, R Bryan Bell.
J Immunother Cancer, 2021 May 09; 9(5). PMID: 33963014    Free PMC article.
Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.
Zhen Bian, Lei Shi, +3 authors, Yuan Liu.
Nat Commun, 2021 May 30; 12(1). PMID: 34050181    Free PMC article.
Nanotechnology synergized immunoengineering for cancer.
Deepak S Chauhan, Anupam Dhasmana, +6 authors, Murali M Yallapu.
Eur J Pharm Biopharm, 2021 Mar 29; 163. PMID: 33774162    Free PMC article.
Immune Checkpoint Inhibitors in Prostate Cancer.
Shobi Venkatachalam, Taylor R McFarland, Neeraj Agarwal, Umang Swami.
Cancers (Basel), 2021 Jun 03; 13(9). PMID: 34063238    Free PMC article.
Combination Therapy, a Promising Approach to Enhance the Efficacy of Radionuclide and Targeted Radionuclide Therapy of Prostate and Breast Cancer.
Tyrillshall S T Damiana, Simone U Dalm.
Pharmaceutics, 2021 Jun 03; 13(5). PMID: 34067215    Free PMC article.
Repositioning Azelnidipine as a Dual Inhibitor Targeting CD47/SIRPα and TIGIT/PVR Pathways for Cancer Immuno-Therapy.
Xiuman Zhou, Ling Jiao, +10 authors, Junhui Chen.
Biomolecules, 2021 Jun 03; 11(5). PMID: 34068552    Free PMC article.
Combined with interventional therapy, immunotherapy can create a new outlook for tumor treatment.
Tonglei Fang, Junyuan Xiao, +3 authors, Yingsheng Cheng.
Quant Imaging Med Surg, 2021 Jun 04; 11(6). PMID: 34079746    Free PMC article.
Research advances on the immune research and prospect of immunotherapy in pituitary adenomas.
Ding Nie, Qiuyue Fang, +5 authors, Peng Zhao.
World J Surg Oncol, 2021 Jun 07; 19(1). PMID: 34090476    Free PMC article.
Radiotherapy and Cytokine Storm: Risk and Mechanism.
Chen Zhang, Zhenzhen Liang, Shumei Ma, Xiaodong Liu.
Front Oncol, 2021 Jun 08; 11. PMID: 34094967    Free PMC article.
Immunotherapy in non-small cell lung cancer: Update and new insights.
Xabier Mielgo-Rubio, Eider Azkona Uribelarrea, Laura Quintanta Cortés, María Sereno Moyano.
J Clin Transl Res, 2021 Jun 10; 7(1). PMID: 34104805    Free PMC article.
In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models.
Takaaki Oba, Kenichi Makino, +7 authors, Fumito Ito.
J Immunother Cancer, 2021 May 30; 9(5). PMID: 34049930    Free PMC article.
Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis.
Shanshan Gou, Shuai Wang, +10 authors, Yanfeng Gao.
Theranostics, 2021 Jun 24; 11(15). PMID: 34158852    Free PMC article.
Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads.
Danielle M Lussier, Elise Alspach, +10 authors, Robert D Schreiber.
Proc Natl Acad Sci U S A, 2021 Jun 09; 118(24). PMID: 34099555    Free PMC article.
Radiotherapy and Renal Cell Carcinoma: A Continuing Saga.
Despoina Spyropoulou, Panagiotis Tsiganos, +8 authors, Dimitrios Kardamakis.
In Vivo, 2021 Apr 30; 35(3). PMID: 33910814    Free PMC article.
Cytoreductive Nephrectomy Promoted Abscopal Effect of Camrelizumab Combined With Radiotherapy for Metastatic Renal Cell Carcinoma: A Case Report and Review of the Literature.
Min Wu, Jie Liu, +2 authors, Jinbo Yue.
Front Immunol, 2021 Jul 03; 12. PMID: 34211459    Free PMC article.
NRG-HN003: Phase I and Expansion Cohort Study of Adjuvant Pembrolizumab, Cisplatin and Radiation Therapy in Pathologically High-Risk Head and Neck Cancer.
Julie E Bauman, Jonathan Harris, +16 authors, Quynh-Thu Le.
Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34207599    Free PMC article.
Neoadjuvant and Adjuvant Immunotherapy in Early-Stage Non-Small Cell Lung Cancer.
Nikhil Shukla, Nasser Hanna.
Lung Cancer (Auckl), 2021 Jul 09; 12. PMID: 34234606    Free PMC article.
Angiogenesis and immune checkpoint dual blockade in combination with radiotherapy for treatment of solid cancers: opportunities and challenges.
Lingling Zhu, Xianzhe Yu, +6 authors, Qinghua Zhou.
Oncogenesis, 2021 Jul 12; 10(7). PMID: 34247198    Free PMC article.
A Deep Insight Into CAR-T Cell Therapy in Non-Hodgkin Lymphoma: Application, Opportunities, and Future Directions.
Faroogh Marofi, Heshu Sulaiman Rahman, +12 authors, Mostafa Jarahian.
Front Immunol, 2021 Jul 13; 12. PMID: 34248965    Free PMC article.
Modulating the Radiation Response for Improved Outcomes in Breast Cancer.
Andrea M Pesch, Lori J Pierce, Corey W Speers.
JCO Precis Oncol, 2021 Jul 13; 5. PMID: 34250414    Free PMC article.
Incidence and risk factors for pneumonitis among patients with lung cancer who received immune checkpoint inhibitors after palliative thoracic radiotherapy.
Satoshi Saito, Takanori Abe, +11 authors, Shingo Kato.
J Radiat Res, 2021 Jun 15; 62(4). PMID: 34121123    Free PMC article.
Heterogeneity of IFN-Mediated Responses and Tumor Immunogenicity in Patients with Cervical Cancer Receiving Concurrent Chemoradiotherapy.
Jianzhou Chen, Chuangzhen Chen, +8 authors, Ruth Muschel.
Clin Cancer Res, 2021 Mar 27; 27(14). PMID: 33766815    Free PMC article.
Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review.
Caressa Hui, Brittney Chau, +3 authors, Arya Amini.
Front Oncol, 2021 Jul 20; 11. PMID: 34277390    Free PMC article.
The Abscopal Effect in the Era of Checkpoint Inhibitors.
Ondřej Kodet, Kristýna Němejcova, +6 authors, Lukáš Lacina.
Int J Mol Sci, 2021 Jul 21; 22(13). PMID: 34281259    Free PMC article.
A narrative review of combined stereotactic ablative radiotherapy and immunotherapy in metastatic non-small cell lung cancer.
Zarique Z Akanda, Paul J Neeson, +5 authors, Shankar Siva.
Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295676    Free PMC article.
A Prospective Trial Evaluating the Safety and Systemic Response From the Concurrent Use of Radiation Therapy with Checkpoint Inhibitor Immunotherapy in Metastatic Non-Small Cell Lung Cancer.
Malcolm D Mattes, Timothy D Eubank, +4 authors, Patrick C Ma.
Clin Lung Cancer, 2021 Feb 21; 22(4). PMID: 33608212    Free PMC article.
Clinical retrospective study on the expression of the PD-L1 molecule in sporadic colorectal cancer and its correlation with K-ras gene mutations in Chinese patients.
Jiasheng Xu, Wenpeng Zhao, +6 authors, Zhenfang Xiong.
Am J Transl Res, 2021 Jul 27; 13(6). PMID: 34306353    Free PMC article.
Local Destruction of Tumors and Systemic Immune Effects.
Karl-Göran Tranberg.
Front Oncol, 2021 Jul 27; 11. PMID: 34307177    Free PMC article.
Myeloid-Derived Suppressor Cells: Implications in the Resistance of Malignant Tumors to T Cell-Based Immunotherapy.
Houhui Shi, Kai Li, +2 authors, Xia Zhao.
Front Cell Dev Biol, 2021 Aug 03; 9. PMID: 34336860    Free PMC article.
The role of PD-1/PD-L1 checkpoint in arsenic lung tumorigenesis.
Wenhua Xu, Jiajun Cui, +2 authors, Gang Chen.
Toxicol Appl Pharmacol, 2021 Jun 25; 426. PMID: 34166680    Free PMC article.
Time-sequential change in immune-related gene expression after irradiation in glioblastoma: next-generation sequencing analysis.
Yi-Jun Kim, Kwangsoo Kim, +8 authors, Jin Ho Kim.
Anim Cells Syst (Seoul), 2021 Aug 20; 25(4). PMID: 34408813    Free PMC article.
Concurrent Sorafenib and Radiotherapy versus Radiotherapy Alone for Locally Advanced Hepatocellular Carcinoma: A Propensity-Matched Analysis.
Chieh-Min Liu, Bing-Shen Huang, +6 authors, Jen-Yu Cheng.
J Hepatocell Carcinoma, 2021 Aug 27; 8. PMID: 34434903    Free PMC article.
Immune Checkpoints: Therapeutic Targets for Pituitary Tumors.
Ding Nie, Yimeng Xue, +7 authors, Peng Zhao.
Dis Markers, 2021 Aug 28; 2021. PMID: 34447484    Free PMC article.
The Role of Immunotherapy in a Tolerogenic Environment: Current and Future Perspectives for Hepatocellular Carcinoma.
Liliana Montella, Federica Sarno, +9 authors, Gaetano Facchini.
Cells, 2021 Aug 28; 10(8). PMID: 34440678    Free PMC article.
Immunotherapy for HPV Malignancies.
Maxwell Y Lee, Clint T Allen.
Semin Radiat Oncol, 2021 Aug 31; 31(4). PMID: 34455991    Free PMC article.
Concurrent use of nivolumab and radiotherapy for patients with metastatic non-small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab.
Jawaher Ansari, Ashraf Farrag, +7 authors, John Glaholm.
Mol Clin Oncol, 2021 Sep 04; 15(4). PMID: 34476098    Free PMC article.
Aggressive pituitary tumours and pituitary carcinomas.
Gérald Raverot, Mirela Diana Ilie, +4 authors, Thierry Brue.
Nat Rev Endocrinol, 2021 Sep 09; 17(11). PMID: 34493834
Phase I Trial of Cemiplimab, Radiotherapy, Cyclophosphamide, and Granulocyte Macrophage Colony-Stimulating Factor in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Hani Babiker, Irene Brana, +18 authors, Elizabeth Stankevich.
Oncologist, 2021 May 05; 26(9). PMID: 33942954    Free PMC article.
Pulsed Radiation Therapy to Improve Systemic Control of Metastatic Cancer.
Kewen He, Hampartsoum B Barsoumian, +9 authors, James W Welsh.
Front Oncol, 2021 Sep 10; 11. PMID: 34497773    Free PMC article.
Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only on HPV-Positive Cells.
Sebastian Wimmer, Lisa Deloch, +8 authors, Udo S Gaipl.
Int J Mol Sci, 2021 Sep 11; 22(17). PMID: 34502022    Free PMC article.
Treatment of Cancer with Radio-Immunotherapy: What We Currently Know and What the Future May Hold.
William Tyler Turchan, Sean P Pitroda, Ralph R Weichselbaum.
Int J Mol Sci, 2021 Sep 11; 22(17). PMID: 34502479    Free PMC article.
Current Landscape of Immunotherapy in Breast Cancer: A Review.
Sylvia Adams, Margaret E Gatti-Mays, +19 authors, Elizabeth A Mittendorf.
JAMA Oncol, 2019 Apr 12; 5(8). PMID: 30973611    Free PMC article.
Radiotherapy Combined with PD-1 Inhibition Increases NK Cell Cytotoxicity towards Nasopharyngeal Carcinoma Cells.
Anna Makowska, Nora Lelabi, +5 authors, Udo Kontny.
Cells, 2021 Sep 29; 10(9). PMID: 34572108    Free PMC article.
Immune checkpoints and immunotherapy in non-small cell lung cancer: Novel study progression, challenges and solutions.
Lin-Rui Ma, Jia-Xin Li, +5 authors, Pei-Yu Yan.
Oncol Lett, 2021 Oct 02; 22(5). PMID: 34594428    Free PMC article.
Role of BCLAF-1 in PD-L1 stabilization in response to ionizing irradiation.
Zhao Ma, Han Wang, +6 authors, Bo Xu.
Cancer Sci, 2021 Jul 13; 112(10). PMID: 34251713    Free PMC article.
Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer.
Neil H Segal, Andrea Cercek, +35 authors, Leonard B Saltz.
Clin Cancer Res, 2021 Jan 29; 27(8). PMID: 33504552    Free PMC article.
Parallels Between the Antiviral State and the Irradiated State.
Heather M McGee, Ariel E Marciscano, +3 authors, John R Teijaro.
J Natl Cancer Inst, 2020 Dec 01; 113(8). PMID: 33252657    Free PMC article.
ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation.
Yuanqin Yang, Meng Wu, +15 authors, Liufu Deng.
Sci Adv, 2021 Oct 07; 7(41). PMID: 34613770    Free PMC article.
Anti-PD-1/Anti-PD-L1 Drugs and Radiation Therapy: Combinations and Optimization Strategies.
Jihane Boustani, Benoît Lecoester, +4 authors, Gilles Truc.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638376    Free PMC article.
Abscopal Effect of Radiotherapy Enhanced with Immune Checkpoint Inhibitors of Triple Negative Breast Cancer in 4T1 Mammary Carcinoma Model.
Haa-Na Song, Hana Jin, +7 authors, Bae-Kwon Jeong.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34638817    Free PMC article.
Melanoma brain metastases that progress on BRAF-MEK inhibitors demonstrate resistance to ipilimumab-nivolumab that is associated with the Innate PD-1 Resistance Signature (IPRES).
Peter Kar Han Lau, Breon Feran, +20 authors, Grant A McArthur.
J Immunother Cancer, 2021 Oct 10; 9(10). PMID: 34625515    Free PMC article.
Immunotherapeutic Advances for NSCLC.
Marco Massafra, Maria Ilenia Passalacqua, +6 authors, Mariacarmela Santarpia.
Biologics, 2021 Oct 23; 15. PMID: 34675481    Free PMC article.
Recent Progress in the Neoadjuvant Treatment Strategy for Locally Advanced Esophageal Cancer.
Sicong Hou, Ziyin Pan, +2 authors, Yanbing Ding.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680311    Free PMC article.
Radiation-Induced Fibrotic Tumor Microenvironment Regulates Anti-Tumor Immune Response.
Jae-Kyung Nam, Ji-Hee Kim, +3 authors, Yoon-Jin Lee.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680381    Free PMC article.
Potentiating Antitumor Efficacy Through Radiation and Sustained Intratumoral Delivery of Anti-CD40 and Anti-PDL1.
Hsuan-Chen Liu, Dixita I Viswanath, +16 authors, Alessandro Grattoni.
Int J Radiat Oncol Biol Phys, 2020 Aug 10; 110(2). PMID: 32768562    Free PMC article.
Current advances in immune checkpoint inhibitor combinations with radiation therapy or cryotherapy for breast cancer.
Alice Y Ho, Shervin Tabrizi, Samantha A Dunn, Heather L McArthur.
Breast Cancer Res Treat, 2021 Oct 30; 191(2). PMID: 34714450
Advances in Combining Radiation and Immunotherapy in Breast Cancer.
Anthony T Nguyen, Stephen L Shiao, Heather L McArthur.
Clin Breast Cancer, 2021 Apr 04; 21(2). PMID: 33810972    Free PMC article.
Kickstarting Immunity in Cold Tumours: Localised Tumour Therapy Combinations With Immune Checkpoint Blockade.
Elizabeth Appleton, Jehanne Hassan, +7 authors, Erik Wennerberg.
Front Immunol, 2021 Nov 05; 12. PMID: 34733287    Free PMC article.
Radiation Plus Anti-PD-1 Therapy for NSCLC Brain Metastases: A Retrospective Study.
Guixiang Liao, Yuting Qian, +8 authors, Muhammad Khan.
Front Oncol, 2021 Nov 09; 11. PMID: 34745964    Free PMC article.
Local, multimodal intralesional therapy renders distant brain metastases susceptible to PD-L1 blockade in a preclinical model of triple-negative breast cancer.
Toshihiro Yokoi, Takaaki Oba, +2 authors, Fumito Ito.
Sci Rep, 2021 Nov 11; 11(1). PMID: 34754037    Free PMC article.
Carbon ion radiotherapy boosts anti-tumour immune responses by inhibiting myeloid-derived suppressor cells in melanoma-bearing mice.
Heng Zhou, Pengfei Yang, +5 authors, Jufang Wang.
Cell Death Discov, 2021 Nov 05; 7(1). PMID: 34732697    Free PMC article.
Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications.
Benjamin T Himes, Philipp A Geiger, +3 authors, Ian F Parney.
Front Oncol, 2021 Nov 16; 11. PMID: 34778089    Free PMC article.
Potential Molecular Targets in the Setting of Chemoradiation for Esophageal Malignancies.
Salma K Jabbour, Terence M Williams, +16 authors, Mansoor M Ahmed.
J Natl Cancer Inst, 2020 Dec 23; 113(6). PMID: 33351071    Free PMC article.
Advances in locoregional therapy for hepatocellular carcinoma combined with immunotherapy and targeted therapy.
Jian Xue, Hongbo Ni, +2 authors, Meng Niu.
J Interv Med, 2021 Nov 23; 4(3). PMID: 34805958    Free PMC article.
Efficacy of single-site radiotherapy plus PD-1 inhibitors vs PD-1 inhibitors for oligometastatic non-small cell lung cancer.
Peiliang Wang, Tianwen Yin, +2 authors, Feifei Teng.
J Cancer Res Clin Oncol, 2021 Nov 24; 148(5). PMID: 34812931    Free PMC article.
Immune checkpoint inhibition for pancreatic ductal adenocarcinoma: limitations and prospects: a systematic review.
Hong-Bo Li, Zi-Han Yang, Qing-Qu Guo.
Cell Commun Signal, 2021 Nov 26; 19(1). PMID: 34819086    Free PMC article.
Recent Research on Combination of Radiotherapy with Targeted Therapy or Immunotherapy in Head and Neck Squamous Cell Carcinoma: A Review for Radiation Oncologists.
Daniel Tao Xing, Richard Khor, +3 authors, Sweet Ping Ng.
Cancers (Basel), 2021 Nov 28; 13(22). PMID: 34830871    Free PMC article.
Prognostic implication of PD-L1 polymorphisms in non-small cell lung cancer treated with radiotherapy.
Min Kyu Kang, Shin Yup Lee, +4 authors, Jae Yong Park.
Cancer Med, 2021 Oct 07; 10(22). PMID: 34612596    Free PMC article.
Combined treatment of non-small cell lung cancer using radiotherapy and immunotherapy: challenges and updates.
Shijie Shang, Jie Liu, +4 authors, Dawei Chen.
Cancer Commun (Lond), 2021 Oct 19; 41(11). PMID: 34658186    Free PMC article.
B7-H3-targeted Radioimmunotherapy of Human Cancer.
Benjamin B Kasten, Soldano Ferrone, Kurt R Zinn, Donald J Buchsbaum.
Curr Med Chem, 2019 Mar 07; 27(24). PMID: 30836909    Free PMC article.
Favorable response to multimodal treatment in hepatocellular carcinoma with inferior vena cava and right atrial tumor thrombus and left adrenal gland metastasis: A case report and literature review.
Ning Sun, Jialin Zhang, +3 authors, Chengshuo Zhang.
Medicine (Baltimore), 2021 Dec 11; 100(49). PMID: 34889243    Free PMC article.
PD-1 Inhibitor Maintenance Therapy Combined Iodine-125 Seed Implantation Successfully Salvage Recurrent Cervical Cancer after CCRT: A Case Report.
Guangchao Wei, Fuxin Guo, +4 authors, Ping Jiang.
Curr Oncol, 2021 Dec 14; 28(6). PMID: 34898560    Free PMC article.
Radiation-activated secretory proteins of Scgb1a1 + club cells increase the efficacy of immune checkpoint blockade in lung cancer.
Yi Ban, Geoffrey J Markowitz, +8 authors, Vivek Mittal.
Nat Cancer, 2021 Dec 18; 2(9). PMID: 34917944    Free PMC article.
Rationale and Design for a Multicenter, Phase II Study of Durvalumab Plus Concurrent Radiation Therapy in Locally Advanced Non-Small Cell Lung Cancer: The DOLPHIN Study (WJOG11619L).
Motoko Tachihara, Kayoko Tsujino, +15 authors, members of the West Japan Oncology Group (WJOG).
Cancer Manag Res, 2021 Dec 23; 13. PMID: 34934361    Free PMC article.
Nivolumab and Stereotactic Radiosurgery for Patients With Breast Cancer Brain Metastases: A Nonrandomized, Open-Label Phase 1b Study.
Kamran A Ahmed, Youngchul Kim, +19 authors, Hyo S Han.
Adv Radiat Oncol, 2021 Dec 23; 6(6). PMID: 34934864    Free PMC article.
The Challenge to the Pathologist of PD-L1 Expression in Tumor Cells of Non-Small-Cell Lung Cancer-An Overview.
Korinna Jöhrens, Josef Rüschoff.
Curr Oncol, 2021 Dec 24; 28(6). PMID: 34940076    Free PMC article.
Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity.
Yuzhu Hou, Hua L Liang, +19 authors, Ralph R Weichselbaum.
Sci Transl Med, 2021 Feb 26; 13(582). PMID: 33627484    Free PMC article.
A case of primary malignant melanoma of the esophagogastric junction with abscopal effect after nivolumab administration.
Takahisa Yamaguchi, Sachio Fushida, +8 authors, Noriyuki Inaki.
Surg Case Rep, 2021 Dec 10; 7(1). PMID: 34882298    Free PMC article.
Combined Treatment with Immunotherapy-Based Strategies for MSS Metastatic Colorectal Cancer.
Iosune Baraibar, Oriol Mirallas, +4 authors, Elena Élez.
Cancers (Basel), 2021 Dec 25; 13(24). PMID: 34944931    Free PMC article.
Combination of Modern Radiotherapy and New Targeted Treatments for Breast Cancer Management.
Arnaud Beddok, Paul Cottu, Alain Fourquet, Youlia Kirova.
Cancers (Basel), 2021 Dec 25; 13(24). PMID: 34944978    Free PMC article.
Potential Reasons for Unresponsiveness to Anti-PD1 Immunotherapy in Young Patients with Advanced Melanoma.
Devayani Machiraju, Sarah Schäfer, Jessica C Hassel.
Life (Basel), 2021 Dec 25; 11(12). PMID: 34947849    Free PMC article.
The Research Progress of PD-1/PD-L1 Inhibitors Enhancing Radiotherapy Efficacy.
Lu Wen, Fan Tong, +3 authors, Xiaorong Dong.
Front Oncol, 2021 Dec 28; 11. PMID: 34956911    Free PMC article.
Systemic Immune Activation and Responses of Irradiation to Different Metastatic Sites Combined With Immunotherapy in Advanced Non-Small Cell Lung Cancer.
Min Wu, Jie Liu, +4 authors, Xue Meng.
Front Immunol, 2022 Jan 01; 12. PMID: 34970277    Free PMC article.
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy.
Bradley N Mills, Haoming Qiu, +11 authors, Scott A Gerber.
Clin Cancer Res, 2021 Dec 05; 28(1). PMID: 34862242    Free PMC article.
Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review.
Yamei Chen, Ying Jin, Xiao Hu, Ming Chen.
J Cancer Res Clin Oncol, 2022 Jan 09; 148(4). PMID: 34997864
Effects of Radiation on the Tumor Microenvironment.
Arta M Monjazeb, Kurt A Schalper, +3 authors, Kristina Young.
Semin Radiat Oncol, 2020 May 10; 30(2). PMID: 32381294    Free PMC article.
Current status of immune checkpoint inhibitor therapy for advanced esophageal squamous cell carcinoma.
Naoki Enomoto, Kazuhiko Yamada, +6 authors, Norihiro Kokudo.
Glob Health Med, 2022 Jan 18; 3(6). PMID: 35036619    Free PMC article.
The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer.
Sheetal Parida, Dipali Sharma.
Biochim Biophys Acta Rev Cancer, 2019 Apr 15; 1871(2). PMID: 30981803    Free PMC article.
Relationship Between Prior Radiotherapy and Checkpoint-Inhibitor Pneumonitis in Patients With Advanced Non-Small-Cell Lung Cancer.
Khinh Ranh Voong, Sarah Z Hazell, +17 authors, Jarushka Naidoo.
Clin Lung Cancer, 2019 Apr 30; 20(4). PMID: 31031204    Free PMC article.
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions.
Ming Yi, Xiaoli Zheng, +3 authors, Kongming Wu.
Mol Cancer, 2022 Jan 23; 21(1). PMID: 35062949    Free PMC article.
Double-refractory Hodgkin lymphoma: tackling relapse after brentuximab vedotin and checkpoint inhibitors.
Narendranath Epperla, Mehdi Hamadani.
Hematology Am Soc Hematol Educ Program, 2021 Dec 11; 2021(1). PMID: 34889401    Free PMC article.
Breast Cancer Tumor Microenvironment and Molecular Aberrations Hijack Tumoricidal Immunity.
Huey-Jen Lin, Yingguang Liu, Denene Lofland, Jiayuh Lin.
Cancers (Basel), 2022 Jan 22; 14(2). PMID: 35053449    Free PMC article.
Case Report: First Case of Consolidation Immunotherapy After Definitive Chemoradiotherapy in Mediastinal Lymph Node Metastatic Sarcomatoid Carcinoma.
Yu Wang, Lin Yang, +7 authors, Nan Bi.
Front Oncol, 2022 Jan 28; 11. PMID: 35083145    Free PMC article.
Pharmacologic inhibition of ataxia telangiectasia and Rad3-related (ATR) in the treatment of head and neck squamous cell carcinoma.
Pooja Karukonda, Diana Odhiambo, Yvonne M Mowery.
Mol Carcinog, 2021 Dec 30; 61(2). PMID: 34964992    Free PMC article.
Trimodality treatment in gastric and gastroesophageal junction cancers: Current approach and future perspectives.
Nikolaos Charalampakis, Sergios Tsakatikas, +9 authors, Jaffer A Ajani.
World J Gastrointest Oncol, 2022 Feb 05; 14(1). PMID: 35116110    Free PMC article.
The utilization of immunotherapy with radiation therapy in lung cancer: a narrative review.
John H Heinzerling, Kathryn F Mileham, Charles B Simone.
Transl Cancer Res, 2022 Feb 05; 10(5). PMID: 35116573    Free PMC article.
Narrative review of immunotherapy and radiation therapy in elderly patients.
Brittney Chau, Jonnby LaGuardia, +4 authors, Arya Amini.
Transl Cancer Res, 2022 Feb 05; 10(5). PMID: 35116575    Free PMC article.
Treatment intensity in locoregionally advanced head and neck cancer: recent investigation leads to new questions.
James A Bonner, Drexell H Boggs.
Transl Cancer Res, 2019 Mar 01; 8(Suppl 2). PMID: 35117096    Free PMC article.
Intracranial radiotherapy with or without immune checkpoint inhibition for brain metastases: a systematic review and meta-analysis.
Qian He, Chi Zhang, +2 authors, Qinglan Ren.
Transl Cancer Res, 2020 Oct 01; 9(10). PMID: 35117204    Free PMC article.
Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial.
Aparna R Parikh, Annamaria Szabolcs, +28 authors, Theodore S Hong.
Nat Cancer, 2022 Feb 06; 2(11). PMID: 35122060    Free PMC article.
Efficacy of pembrolizumab and comprehensive CD274/PD-L1 profiles in patients previously treated with chemoradiation therapy as radical treatment in bladder cancer.
Kazuki Nishimura, Kyosuke Nishio, +23 authors, Haruhito Azuma.
J Immunother Cancer, 2022 Jan 19; 10(1). PMID: 35039462    Free PMC article.
Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma.
Zhuochao Liu, Junxiang Wen, +3 authors, Weibin Zhang.
Cancer Sci, 2021 Dec 21; 113(2). PMID: 34927311    Free PMC article.
Anlotinib Enhances the Antitumor Activity of High-Dose Irradiation Combined with Anti-PD-L1 by Potentiating the Tumor Immune Microenvironment in Murine Lung Cancer.
Meng Yuan, Yirui Zhai, +9 authors, Zhouguang Hui.
Oxid Med Cell Longev, 2022 Feb 15; 2022. PMID: 35154567    Free PMC article.
Neoadjuvant SABR for Renal Cell Carcinoma Inferior Vena Cava Tumor Thrombus-Safety Lead-in Results of a Phase 2 Trial.
Vitaly Margulis, Yuval Freifeld, +14 authors, Raquibul Hannan.
Int J Radiat Oncol Biol Phys, 2021 Feb 08; 110(4). PMID: 33549705    Free PMC article.
Radiotherapy: Brightness and darkness in the era of immunotherapy.
Danyi Zhai, Dandan An, Chao Wan, Kunyu Yang.
Transl Oncol, 2022 Feb 27; 19. PMID: 35219093    Free PMC article.
Evolving management of HER2+ breast cancer brain metastases and leptomeningeal disease.
Matthew N Mills, Whitney King, +6 authors, Kamran A Ahmed.
J Neurooncol, 2022 Mar 05; 157(2). PMID: 35244835
Immunosuppressive properties of human PD-1 + , PDL-1 + and CD80 + dendritic cells from lymph nodes aspirates of lung cancer patients.
Iwona Kwiecień, Elżbieta Rutkowska, +5 authors, Joanna Domagała-Kulawik.
Cancer Immunol Immunother, 2022 Mar 08;. PMID: 35254478
cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy.
Zi-Jie Long, Jun-Dan Wang, +2 authors, Quentin Liu.
Mol Ther, 2022 Feb 06; 30(3). PMID: 35121107    Free PMC article.
Anti-PD-L1 Antibody Enhances T Cell Immune Responses and Reduces Resistance of Breast Cancer Cells to Radiotherapy.
Lei-Ming Guo, Gao-Feng Ding, +3 authors, Yu-Fei Lu.
Oxid Med Cell Longev, 2022 Mar 18; 2022. PMID: 35295718    Free PMC article.
Novel imaging biomarkers predict outcomes in stage III unresectable non-small cell lung cancer treated with chemoradiation and durvalumab.
Khalid Jazieh, Mohammadhadi Khorrami, +10 authors, Anant Madabhushi.
J Immunother Cancer, 2022 Mar 09; 10(3). PMID: 35256515    Free PMC article.
The Treatment Landscape of Advanced Hepatocellular Carcinoma.
Kit Man Wong, Gentry G King, William P Harris.
Curr Oncol Rep, 2022 Mar 30; 24(7). PMID: 35347594
Carbon ion radiotherapy triggers immunogenic cell death and sensitizes melanoma to anti-PD-1 therapy in mice.
Heng Zhou, Chen Tu, +9 authors, Jufang Wang.
Oncoimmunology, 2022 Apr 01; 11(1). PMID: 35355680    Free PMC article.
HLA class I antigen processing machinery defects in antitumor immunity and immunotherapy.
Luke Maggs, Ananthan Sadagopan, Ali Sanjari Moghaddam, Soldano Ferrone.
Trends Cancer, 2021 Sep 08; 7(12). PMID: 34489208    Free PMC article.
Functional Diversities of Regulatory T Cells in the Context of Cancer Immunotherapy.
Ran Gao, Guo-Ping Shi, Jing Wang.
Front Immunol, 2022 Apr 05; 13. PMID: 35371055    Free PMC article.
A Patient-Level Data Meta-analysis of the Abscopal Effect.
Steven J Hatten, Eric J Lehrer, +7 authors, Nicholas G Zaorsky.
Adv Radiat Oncol, 2022 Apr 05; 7(3). PMID: 35372719    Free PMC article.
Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060).
Meichen Li, Xue Hou, +9 authors, Likun Chen.
Oncoimmunology, 2022 Apr 12; 11(1). PMID: 35402080    Free PMC article.
Immunomodulatory effect of splenectomy in lung cancer mouse xenograft models receiving radiation therapy.
Yeeun Kim, Changhoon Choi, +4 authors, Jae Myoung Noh.
Radiat Oncol J, 2022 Apr 05; 40(1). PMID: 35368201    Free PMC article.
Multimodality Treatment including Surgery Related to the Type of N2 Involvement in Locally Advanced Non-Small Cell Lung Cancer.
Toon Allaeys, Lawek Berzenji, +5 authors, Paul E Van Schil.
Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406428    Free PMC article.
Rationale and design of a prospective, multicenter, phase II clinical trial of safety and efficacy evaluation of long course neoadjuvant chemoradiotherapy plus tislelizumab followed by total mesorectal excision for locally advanced rectal cancer (NCRT-PD1-LARC trial).
Zhengyang Yang, Xiao Zhang, +14 authors, Zhongtao Zhang.
BMC Cancer, 2022 Apr 29; 22(1). PMID: 35477432    Free PMC article.
Combining Radiotherapy and Immunotherapy in Metastatic Breast Cancer: Current Status and Future Directions.
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Biomedicines, 2022 Apr 24; 10(4). PMID: 35453571    Free PMC article.
Consolidation treatments after chemoradiotherapy in patients with locally advanced inoperable non-small cell lung cancer: a systematic review and network meta-analysis protocol.
Ye Zhao, Haiming Feng, +6 authors, Qin Yu.
BMJ Open, 2022 Apr 14; 12(4). PMID: 35414564    Free PMC article.
Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system.
Rebecca Anne Bekker, Sungjune Kim, Shari Pilon-Thomas, Heiko Enderling.
Neoplasia, 2022 Apr 22; 28. PMID: 35447601    Free PMC article.
Current status and advances of immunotherapy in nasopharyngeal carcinoma.
Jian-Ying Xu, Xiao-Li Wei, Yi-Qin Wang, Feng-Hua Wang.
Ther Adv Med Oncol, 2022 May 14; 14. PMID: 35547095    Free PMC article.
A review of mechanisms of resistance to immune checkpoint inhibitors and potential strategies for therapy.
Yu Fujiwara, Arjun Mittra, Abdul Rafeh Naqash, Naoko Takebe.
Cancer Drug Resist, 2020 Jun 18; 3(3). PMID: 35582437    Free PMC article.
Mechanism of resistance to immune checkpoint inhibitors.
Manu R Pandey, Marc S Ernstoff.
Cancer Drug Resist, 2019 Jun 19; 2(2). PMID: 35582715    Free PMC article.
Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities.
Tae Kon Kim, Esten N Vandsemb, Roy S Herbst, Lieping Chen.
Nat Rev Drug Discov, 2022 Jun 15;. PMID: 35701637