Journal Article
. 2014 May; 1(1):3-7.

Challenges in the Treatment of Triple Negative and HER2-Overexpressing Breast Cancer

L Alexis Hoeferlin 1 Charles E Chalfant 1 Margaret A Park 1 
Affiliations
  • PMID: 24818173
  •     39 References
  •     12 citations

Abstract

While the 5-year survival rate of breast cancer is at an all-time high of 90%, this disease remains the second most common cause of cancer-related death, surpassed only by lung cancer in the US. The reasons for this discrepancy stem from cancer subtypes which become resistant to current therapies. These subtypes: "Triple negative" and ErbB2-overexpressing, are discussed in this review.

Keywords: Breast Cancer; ErbB2; Estrogen receptor; Resistance; Triple negative.

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