Review
. 2014 Aug; 20(4):256-61.
doi: 10.1097/PPO.0000000000000061.

Inducible expression of B7-H1 (PD-L1) and its selective role in tumor site immune modulation

Miguel F Sanmamed 1 Lieping Chen  
Affiliations
  • PMID: 25098285
  •     50 References
  •     62 citations

Abstract

Immune evasion is an important hallmark of cancer, and a better understanding of this mechanism is essential for the development of effective strategies against cancer. The B7 homolog 1 (B7-H1)/programmed cell death 1 (PD-1) pathway has been demonstrated as a major mechanism of immune evasion in tumor site, and its blockade therapy shows very encouraging results in clinical trials. Inducible B7-H1 expression in tumor microenvironment is complex, with multidimensional interactions and expression by different subsets of hematopoietic and nonhematopoietic cells. Understanding these interactions and how tumors take advantage of this pathway can help us design future strategies for better therapeutic efficacy and to overcome resistances.

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Mingqiang Liang, Fengqiang Yu, +5 authors, Chun Chen.
Transl Cancer Res, 2020 Apr 01; 9(4). PMID: 35117606    Free PMC article.
Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non-small cell lung cancer.
Qingyuan Huang, Fei Li, +17 authors, Kwok-Kin Wong.
Sci Adv, 2022 Feb 05; 8(5). PMID: 35119931    Free PMC article.
Evaluation of MMR Status and PD-L1 Expression Using Specimens Obtained by EUS-FNB in Patients with Pancreatic Ductal Adenocarcinoma (PDAC).
Alina Constantin, Vlad Iovănescu, +5 authors, Adrian Săftoiu.
Diagnostics (Basel), 2022 Feb 26; 12(2). PMID: 35204385    Free PMC article.
Diagnostic Performance of PD-L1 versus PD-1 Expression in Circulating CD20 Cells in Diffuse Large B-Cell Lymphoma.
Manal Mohamed Saber.
Antibodies (Basel), 2022 Mar 01; 11(1). PMID: 35225873    Free PMC article.
Differential expression of PD‑L1 and PD‑L2 is associated with the tumor microenvironment of TILs and M2 TAMs and tumor differentiation in non‑small cell lung cancer.
Ryota Sumitomo, Cheng-Long Huang, +2 authors, Hiroshi Date.
Oncol Rep, 2022 Feb 17; 47(4). PMID: 35169863    Free PMC article.
Role of Hypoxia in the Interferon Response.
Esther Arnaiz, Adrian L Harris.
Front Immunol, 2022 Mar 08; 13. PMID: 35251003    Free PMC article.
Review.
Uncovering Pharmacological Opportunities for Cancer Stem Cells-A Systems Biology View.
Cristina Correia, Taylor M Weiskittel, +4 authors, Hu Li.
Front Cell Dev Biol, 2022 Apr 02; 10. PMID: 35359437    Free PMC article.
Review.
Phagocytosis checkpoints as new targets for cancer immunotherapy.
Mingye Feng, Wen Jiang, +3 authors, Irving L Weissman.
Nat Rev Cancer, 2019 Aug 30; 19(10). PMID: 31462760    Free PMC article.
Highly Cited. Review.