Journal Article
. 2014 Aug; 111(36):13145-50.
doi: 10.1073/pnas.1412008111.

Commensal bacteria protect against food allergen sensitization

Andrew T Stefka 1 Taylor Feehley 1 Prabhanshu Tripathi 1 Ju Qiu 2 Kathy McCoy 3 Sarkis K Mazmanian 4 Melissa Y Tjota 5 Goo-Young Seo 1 Severine Cao 1 Betty R Theriault 6 Dionysios A Antonopoulos 7 Liang Zhou 2 Eugene B Chang 5 Yang-Xin Fu 1 Cathryn R Nagler 8 
Affiliations
  • PMID: 25157157
  •     39 References
  •     264 citations

Abstract

Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selectively colonizing gnotobiotic mice, we demonstrate that the allergy-protective capacity is conferred by a Clostridia-containing microbiota. Microarray analysis of intestinal epithelial cells from gnotobiotic mice revealed a previously unidentified mechanism by which Clostridia regulate innate lymphoid cell function and intestinal epithelial permeability to protect against allergen sensitization. Our findings will inform the development of novel approaches to prevent or treat food allergy based on modulating the composition of the intestinal microbiota.

Keywords: IL-22; barrier; microbiome.

The 2S albumin allergens of Arachis hypogaea, Ara h 2 and Ara h 6, are the major elicitors of anaphylaxis and can effectively desensitize peanut-allergic mice.
M Kulis, X Chen, +8 authors, S C Dreskin.
Clin Exp Allergy, 2012 Feb 01; 42(2). PMID: 22288514    Free PMC article.
Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization.
Jessica H Savage, Elizabeth C Matsui, Robert A Wood, Corinne A Keet.
J Allergy Clin Immunol, 2012 Jun 19; 130(2). PMID: 22704536    Free PMC article.
Mother's and offspring's use of antibiotics and infant allergy to cow's milk.
Johanna Metsälä, Annamari Lundqvist, +3 authors, Suvi M Virtanen.
Epidemiology, 2013 Jan 26; 24(2). PMID: 23348066
Reciprocal interactions of the intestinal microbiota and immune system.
Craig L Maynard, Charles O Elson, Robin D Hatton, Casey T Weaver.
Nature, 2012 Sep 14; 489(7415). PMID: 22972296    Free PMC article.
Highly Cited. Review.
Induction of colonic regulatory T cells by indigenous Clostridium species.
Koji Atarashi, Takeshi Tanoue, +14 authors, Kenya Honda.
Science, 2011 Jan 06; 331(6015). PMID: 21205640    Free PMC article.
Highly Cited.
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.
Yan Zheng, Dimitry M Danilenko, +4 authors, Wenjun Ouyang.
Nature, 2006 Dec 26; 445(7128). PMID: 17187052
Highly Cited.
IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium.
Naruhisa Ota, Kit Wong, +4 authors, Wenjun Ouyang.
Nat Immunol, 2011 Aug 30; 12(10). PMID: 21874025
Highly Cited.
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.
Usriansyah Hadis, Benjamin Wahl, +7 authors, Oliver Pabst.
Immunity, 2011 Feb 22; 34(2). PMID: 21333554
Highly Cited.
Therapeutic opportunities of the IL-22-IL-22R1 system.
Robert Sabat, Wenjun Ouyang, Kerstin Wolk.
Nat Rev Drug Discov, 2014 Jan 01; 13(1). PMID: 24378801
Highly Cited. Review.
The induction of Treg cells by gut-indigenous Clostridium.
Yuji Nagano, Kikuji Itoh, Kenya Honda.
Curr Opin Immunol, 2012 Jun 08; 24(4). PMID: 22673877
Review.
CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization.
Femke van Wijk, Sanne Hoeks, +5 authors, Raymond Pieters.
J Immunol, 2004 Dec 22; 174(1). PMID: 15611239
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens.
Yan Zheng, Patricia A Valdez, +8 authors, Wenjun Ouyang.
Nat Med, 2008 Feb 12; 14(3). PMID: 18264109
Highly Cited.
Intestinal bacterial colonization induces mutualistic regulatory T cell responses.
Markus B Geuking, Julia Cahenzli, +5 authors, Andrew J Macpherson.
Immunity, 2011 May 21; 34(5). PMID: 21596591
Highly Cited.
Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine.
Elia D Tait Wojno, David Artis.
Cell Host Microbe, 2012 Oct 23; 12(4). PMID: 23084914    Free PMC article.
Review.
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.
Patrick M Smith, Michael R Howitt, +5 authors, Wendy S Garrett.
Science, 2013 Jul 06; 341(6145). PMID: 23828891    Free PMC article.
Highly Cited.
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.
Nicholas Arpaia, Clarissa Campbell, +8 authors, Alexander Y Rudensky.
Nature, 2013 Nov 15; 504(7480). PMID: 24226773    Free PMC article.
Highly Cited.
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.
Gregory F Sonnenberg, Laurel A Monticelli, +21 authors, David Artis.
Science, 2012 Jun 08; 336(6086). PMID: 22674331    Free PMC article.
Highly Cited.
The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
Susan M Sa, Patricia A Valdez, +8 authors, Wenjun Ouyang.
J Immunol, 2007 Feb 06; 178(4). PMID: 17277128
Highly Cited.
The role of commensal bacteria in the regulation of sensitization to food allergens.
Severine Cao, Taylor J Feehley, Cathryn R Nagler.
FEBS Lett, 2014 May 06; 588(22). PMID: 24791655    Free PMC article.
Review.
Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation?
Guénolée Prioult, Cathryn Nagler-Anderson.
Immunol Rev, 2005 Jul 29; 206. PMID: 16048551
Review.
Epithelial antimicrobial defence of the skin and intestine.
Richard L Gallo, Lora V Hooper.
Nat Rev Immunol, 2012 Jun 26; 12(7). PMID: 22728527    Free PMC article.
Highly Cited. Review.
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.
Koji Atarashi, Takeshi Tanoue, +19 authors, Kenya Honda.
Nature, 2013 Jul 12; 500(7461). PMID: 23842501
Highly Cited.
Antibiotic overuse: Stop the killing of beneficial bacteria.
Martin Blaser.
Nature, 2011 Aug 26; 476(7361). PMID: 21866137
Highly Cited.
The human microbiome: at the interface of health and disease.
Ilseung Cho, Martin J Blaser.
Nat Rev Genet, 2012 Mar 14; 13(4). PMID: 22411464    Free PMC article.
Highly Cited. Review.
Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma.
Shannon L Russell, Matthew J Gold, +8 authors, Brett B Finlay.
EMBO Rep, 2012 Mar 17; 13(5). PMID: 22422004    Free PMC article.
Highly Cited.
Hay fever, hygiene, and household size.
D P Strachan.
BMJ, 1989 Nov 18; 299(6710). PMID: 2513902    Free PMC article.
Highly Cited.
The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens.
N Lycke, U Karlsson, A Sjölander, K E Magnusson.
Scand J Immunol, 1991 Jun 01; 33(6). PMID: 1710819
The future of food allergy therapeutics.
Michele Henson, A Wesley Burks.
Semin Immunopathol, 2012 Jun 28; 34(5). PMID: 22735939    Free PMC article.
Review.
The germless theory of allergic disease: revisiting the hygiene hypothesis.
M Wills-Karp, J Santeliz, C L Karp.
Nat Rev Immunol, 2002 Mar 22; 1(1). PMID: 11905816
Highly Cited. Review.
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.
Stefanie Kirchberger, Daniel J Royston, +5 authors, Fiona Powrie.
J Exp Med, 2013 Apr 17; 210(5). PMID: 23589566    Free PMC article.
Highly Cited.
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.
Lisa A Mielke, Sarah A Jones, +9 authors, Kingston H G Mills.
J Exp Med, 2013 May 22; 210(6). PMID: 23690441    Free PMC article.
Highly Cited.
Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice.
Kabir S Matharu, Emiko Mizoguchi, +14 authors, Cathryn R Nagler.
Gastroenterology, 2009 Jul 15; 137(4). PMID: 19596011    Free PMC article.
Food allergy: an enigmatic epidemic.
M Cecilia Berin, Hugh A Sampson.
Trends Immunol, 2013 May 08; 34(8). PMID: 23648309    Free PMC article.
Review.
Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora.
Ju Qiu, Xiaohuan Guo, +5 authors, Liang Zhou.
Immunity, 2013 Aug 21; 39(2). PMID: 23954130    Free PMC article.
Highly Cited.
Man the barrier! Strategic defences in the intestinal mucosa.
C Nagler-Anderson.
Nat Rev Immunol, 2002 Mar 22; 1(1). PMID: 11905815
Review.
Microbial regulation of allergic responses to food.
Taylor Feehley, Andrew T Stefka, Severine Cao, Cathryn R Nagler.
Semin Immunopathol, 2012 Sep 04; 34(5). PMID: 22941410    Free PMC article.
Review.
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
Yukihiro Furusawa, Yuuki Obata, +27 authors, Hiroshi Ohno.
Nature, 2013 Nov 15; 504(7480). PMID: 24226770
Highly Cited.
Lymphotoxin regulates commensal responses to enable diet-induced obesity.
Vaibhav Upadhyay, Valeriy Poroyko, +10 authors, Yang-Xin Fu.
Nat Immunol, 2012 Aug 28; 13(10). PMID: 22922363    Free PMC article.
Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy.
Mohamed Elfatih H Bashir, Steve Louie, Hai Ning Shi, Cathryn Nagler-Anderson.
J Immunol, 2004 May 22; 172(11). PMID: 15153518
Highly Cited.
Science is innate!
Jack A Gilbert.
Genome Biol, 2014 Oct 16; 15(10). PMID: 25315295    Free PMC article.
Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens.
Taylor Feehley, Cathryn R Nagler.
Curr Opin Immunol, 2014 Dec 03; 31. PMID: 25458998    Free PMC article.
Review.
The interplay between the intestinal microbiota and the immune system.
Yuk Man Kevin Lei, Lekha Nair, Maria-Luisa Alegre.
Clin Res Hepatol Gastroenterol, 2014 Dec 08; 39(1). PMID: 25481240    Free PMC article.
Review.
Gut microbes and adverse food reactions: Focus on gluten related disorders.
Heather J Galipeau, Elena F Verdu.
Gut Microbes, 2014 Dec 09; 5(5). PMID: 25483329    Free PMC article.
Review.
The microbiome in asthma.
Yvonne J Huang, Homer A Boushey.
J Allergy Clin Immunol, 2015 Jan 09; 135(1). PMID: 25567040    Free PMC article.
Highly Cited. Review.
Diagnosis, management, and investigational therapies for food allergies.
Mike Kulis, Benjamin L Wright, Stacie M Jones, A Wesley Burks.
Gastroenterology, 2015 Jan 31; 148(6). PMID: 25633563    Free PMC article.
Review.
Our interface with the built environment: immunity and the indoor microbiota.
Simon Lax, Cathryn R Nagler, Jack A Gilbert.
Trends Immunol, 2015 Mar 11; 36(3). PMID: 25754179    Free PMC article.
Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients.
Daniel McDonald, Mady Hornig, +3 authors, Rob Knight.
Microb Ecol Health Dis, 2015 Mar 12; 26. PMID: 25758371    Free PMC article.
Chlamydia caviae infection alters abundance but not composition of the guinea pig vaginal microbiota.
Elizabeth Neuendorf, Pawel Gajer, +10 authors, Jacques Ravel.
Pathog Dis, 2015 Mar 13; 73(4). PMID: 25761873    Free PMC article.
The role of the commensal microbiota in the regulation of tolerance to dietary allergens.
Roberto Berni Canani, Jack A Gilbert, Cathryn R Nagler.
Curr Opin Allergy Clin Immunol, 2015 Apr 02; 15(3). PMID: 25827065    Free PMC article.
Review.
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.
Jessica M Yano, Kristie Yu, +7 authors, Elaine Y Hsiao.
Cell, 2015 Apr 11; 161(2). PMID: 25860609    Free PMC article.
Highly Cited.
Alteration of the rat cecal microbiome during colonization with the helminth Hymenolepis diminuta.
Erin A McKenney, Lauren Williamson, +3 authors, William Parker.
Gut Microbes, 2015 May 06; 6(3). PMID: 25942385    Free PMC article.
Antibiotics, pediatric dysbiosis, and disease.
Pajau Vangay, Tonya Ward, Jeffrey S Gerber, Dan Knights.
Cell Host Microbe, 2015 May 15; 17(5). PMID: 25974298    Free PMC article.
Highly Cited. Review.
New developments providing mechanistic insight into the impact of the microbiota on allergic disease.
Kathy D McCoy, Yasmin Köller.
Clin Immunol, 2015 May 20; 159(2). PMID: 25988860    Free PMC article.
Review.
Inflammation-associated microbiota in pediatric eosinophilic esophagitis.
Alain J Benitez, Christian Hoffmann, +4 authors, Mei-Lun Wang.
Microbiome, 2015 Jun 03; 3. PMID: 26034601    Free PMC article.
Antibiotics promote inflammation through the translocation of native commensal colonic bacteria.
Kathryn A Knoop, Keely G McDonald, Devesha H Kulkarni, Rodney D Newberry.
Gut, 2015 Jun 06; 65(7). PMID: 26045138    Free PMC article.
Highly Cited.
Functions of dendritic-cell-bound IgE in allergy.
Barbara Platzer, Madeleine Stout, Edda Fiebiger.
Mol Immunol, 2015 Jun 09; 68(2 Pt A). PMID: 26052071    Free PMC article.
Review.
The Role of Intestinal Microbiota in Acute Graft-versus-Host Disease.
Yuanyuan Chen, Ye Zhao, +2 authors, Haiyan Liu.
J Immunol Res, 2015 Jun 20; 2015. PMID: 26090477    Free PMC article.
Review.
The tragic fate of group 3 innate lymphoid cells during HIV-1 infection.
Xiaohuan Guo, Yang-Xin Fu.
J Clin Invest, 2015 Aug 25; 125(9). PMID: 26301808    Free PMC article.
Review.
Breast Milk and Solid Food Shaping Intestinal Immunity.
Sara M Parigi, Maria Eldh, +2 authors, Eduardo J Villablanca.
Front Immunol, 2015 Sep 09; 6. PMID: 26347740    Free PMC article.
Review.
Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants.
Roberto Berni Canani, Naseer Sangwan, +7 authors, Cathryn R Nagler.
ISME J, 2015 Sep 24; 10(3). PMID: 26394008    Free PMC article.
Highly Cited.
Gut Microbiome and the Development of Food Allergy and Allergic Disease.
Benjamin T Prince, Mark J Mandel, Kari Nadeau, Anne Marie Singh.
Pediatr Clin North Am, 2015 Oct 13; 62(6). PMID: 26456445    Free PMC article.
Review.
Intestinal microbiota modulates gluten-induced immunopathology in humanized mice.
Heather J Galipeau, Justin L McCarville, +9 authors, Elena F Verdu.
Am J Pathol, 2015 Oct 13; 185(11). PMID: 26456581    Free PMC article.
Recent advances in the pathological understanding of eosinophilic esophagitis.
Antonella Cianferoni, Jonathan M Spergel, Amanda Muir.
Expert Rev Gastroenterol Hepatol, 2015 Oct 17; 9(12). PMID: 26470602    Free PMC article.
Review.
Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity.
Lisa A Reynolds, B Brett Finlay, Rick M Maizels.
J Immunol, 2015 Oct 20; 195(9). PMID: 26477048    Free PMC article.
Review.
A comprehensive review of the nasal microbiome in chronic rhinosinusitis (CRS).
M Mahdavinia, A Keshavarzian, +2 authors, R P Schleimer.
Clin Exp Allergy, 2015 Oct 29; 46(1). PMID: 26510171    Free PMC article.
Review.
Microbial diversity--exploration of natural ecosystems and microbiomes.
Sean M Gibbons, Jack A Gilbert.
Curr Opin Genet Dev, 2015 Nov 26; 35. PMID: 26598941    Free PMC article.
Review.
Three Novel Candidate Probiotic Strains with Prophylactic Properties in a Murine Model of Cow's Milk Allergy.
Elodie Neau, Johanne Delannoy, +6 authors, Anne-Judith Waligora-Dupriet.
Appl Environ Microbiol, 2016 Jan 06; 82(6). PMID: 26729723    Free PMC article.
Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota.
Feng Wang, Jess L Kaplan, +20 authors, Kirill S Korolev.
Cell Rep, 2016 Jan 26; 14(4). PMID: 26804920    Free PMC article.
The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?
Javier Ochoa-Repáraz, Lloyd H Kasper.
Curr Obes Rep, 2016 Feb 13; 5(1). PMID: 26865085    Free PMC article.
Review.
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease.
Sean W Mateer, Jocelle Cardona, +3 authors, Simon Keely.
J Vis Exp, 2016 Feb 20; (108). PMID: 26891144    Free PMC article.
Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment.
Onyinye I Iweala, A Wesley Burks.
Curr Allergy Asthma Rep, 2016 Apr 05; 16(5). PMID: 27041704
Review.
Molecular and cellular mechanisms of food allergy and food tolerance.
R Sharon Chinthrajah, Joseph D Hernandez, +2 authors, Kari C Nadeau.
J Allergy Clin Immunol, 2016 Apr 10; 137(4). PMID: 27059726    Free PMC article.
Highly Cited. Review.
Are genetic tests informative in predicting food allergy?
Jin Li, S Melkorka Maggadottir, Hakon Hakonarson.
Curr Opin Allergy Clin Immunol, 2016 Apr 14; 16(3). PMID: 27070332    Free PMC article.
Review.
The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation.
Amy Langdon, Nathan Crook, Gautam Dantas.
Genome Med, 2016 Apr 15; 8(1). PMID: 27074706    Free PMC article.
Highly Cited. Review.
Development and maintenance of intestinal regulatory T cells.
Takeshi Tanoue, Koji Atarashi, Kenya Honda.
Nat Rev Immunol, 2016 Apr 19; 16(5). PMID: 27087661
Highly Cited. Review.
The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease.
Duane R Wesemann, Cathryn R Nagler.
Immunity, 2016 Apr 21; 44(4). PMID: 27096316    Free PMC article.
Review.
The possible mechanisms of the human microbiome in allergic diseases.
Kagan Ipci, Niyazi Altıntoprak, +2 authors, Cemal Cingi.
Eur Arch Otorhinolaryngol, 2016 Apr 27; 274(2). PMID: 27115907
Review.
The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions.
Philipp Engel, Waldan K Kwong, +30 authors, Benjamin Dainat.
mBio, 2016 Apr 28; 7(2). PMID: 27118586    Free PMC article.
Highly Cited. Review.
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Tommi Vatanen, Aleksandar D Kostic, +23 authors, Ramnik J Xavier.
Cell, 2016 May 03; 165(4). PMID: 27133167    Free PMC article.
Highly Cited.
Toward precision medicine and health: Opportunities and challenges in allergic diseases.
Stephen Joseph Galli.
J Allergy Clin Immunol, 2016 May 09; 137(5). PMID: 27155026    Free PMC article.
Review.
Microbiome therapeutics - Advances and challenges.
Mark Mimee, Robert J Citorik, Timothy K Lu.
Adv Drug Deliv Rev, 2016 May 10; 105(Pt A). PMID: 27158095    Free PMC article.
Review.
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Yusuke Shono, Melissa D Docampo, +30 authors, Robert R Jenq.
Sci Transl Med, 2016 May 20; 8(339). PMID: 27194729    Free PMC article.
Highly Cited.
A roadmap for gene system development in Clostridium.
Nigel P Minton, Muhammad Ehsaan, +8 authors, Ying Zhang.
Anaerobe, 2016 May 29; 41. PMID: 27234263    Free PMC article.
Review.
Metabolic Model-Based Integration of Microbiome Taxonomic and Metabolomic Profiles Elucidates Mechanistic Links between Ecological and Metabolic Variation.
Cecilia Noecker, Alexander Eng, +5 authors, Elhanan Borenstein.
mSystems, 2016 May 31; 1(1). PMID: 27239563    Free PMC article.
Highly Cited.
Microbiome and its impact on gastrointestinal atopy.
A B Muir, A J Benitez, +2 authors, S A Fillon.
Allergy, 2016 May 31; 71(9). PMID: 27240281    Free PMC article.
Review.
Activation of Immune and Defense Responses in the Intestinal Mucosa by Outer Membrane Vesicles of Commensal and Probiotic Escherichia coli Strains.
María José Fábrega, Laura Aguilera, +5 authors, Laura Baldomà.
Front Microbiol, 2016 Jun 01; 7. PMID: 27242727    Free PMC article.
Early-life gut microbiome composition and milk allergy resolution.
Supinda Bunyavanich, Nan Shen, +8 authors, Jose C Clemente.
J Allergy Clin Immunol, 2016 Jun 14; 138(4). PMID: 27292825    Free PMC article.
Highly Cited.
Emerging roles for antigen presentation in establishing host-microbiome symbiosis.
Nicholas J Bessman, Gregory F Sonnenberg.
Immunol Rev, 2016 Jun 21; 272(1). PMID: 27319348    Free PMC article.
Review.
The composition of the microbiota modulates allograft rejection.
Yuk Man Lei, Luqiu Chen, +10 authors, Maria-Luisa Alegre.
J Clin Invest, 2016 Jun 21; 126(7). PMID: 27322054    Free PMC article.
The rise of food allergy: Environmental factors and emerging treatments.
Sara Benedé, Ana Belen Blázquez, +2 authors, M Cecilia Berin.
EBioMedicine, 2016 Jun 21; 7. PMID: 27322456    Free PMC article.
Review.
Novel perspectives on therapeutic modulation of the gut microbiota.
Justin L McCarville, Alberto Caminero, Elena F Verdu.
Therap Adv Gastroenterol, 2016 Jul 02; 9(4). PMID: 27366225    Free PMC article.
Review.
The microbiome and innate immunity.
Christoph A Thaiss, Niv Zmora, Maayan Levy, Eran Elinav.
Nature, 2016 Jul 08; 535(7610). PMID: 27383981
Highly Cited. Review.
The microbiota in adaptive immune homeostasis and disease.
Kenya Honda, Dan R Littman.
Nature, 2016 Jul 08; 535(7610). PMID: 27383982
Highly Cited. Review.
The microbiome in early life: implications for health outcomes.
Sabrina Tamburini, Nan Shen, Han Chih Wu, Jose C Clemente.
Nat Med, 2016 Jul 09; 22(7). PMID: 27387886
Highly Cited. Review.
A humanized mouse model of anaphylactic peanut allergy.
Oliver T Burton, Amanda J Stranks, +3 authors, Hans C Oettgen.
J Allergy Clin Immunol, 2016 Jul 16; 139(1). PMID: 27417025    Free PMC article.
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Myles R Minter, Can Zhang, +10 authors, Sangram S Sisodia.
Sci Rep, 2016 Jul 23; 6. PMID: 27443609    Free PMC article.
Highly Cited.
Toward revision of antimicrobial therapies in hematopoietic stem cell transplantation: target the pathogens, but protect the indigenous microbiota.
Alexander Khoruts, Keli L Hippen, +3 authors, Jo-Anne H Young.
Transl Res, 2016 Aug 12; 179. PMID: 27513211    Free PMC article.
Review.
Antibiotic prescription and food allergy in young children.
Bryan L Love, Joshua R Mann, +3 authors, David J Amrol.
Allergy Asthma Clin Immunol, 2016 Aug 19; 12. PMID: 27536320    Free PMC article.
LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
Irina Proekt, Corey N Miller, +6 authors, Anthony L DeFranco.
J Clin Invest, 2016 Aug 30; 126(10). PMID: 27571405    Free PMC article.
Regulatory T cells in allergic diseases.
Magali Noval Rivas, Talal A Chatila.
J Allergy Clin Immunol, 2016 Sep 07; 138(3). PMID: 27596705    Free PMC article.
Highly Cited. Review.
Balancing Tolerance or Allergy to Food Proteins.
Paul J Bryce.
Trends Immunol, 2016 Sep 08; 37(10). PMID: 27600681    Free PMC article.
Review.
Transitioning From Descriptive to Mechanistic Understanding of the Microbiome: The Need for a Prospective Longitudinal Approach to Predicting Disease.
Victoria J Martin, Maureen M Leonard, Lauren Fiechtner, Alessio Fasano.
J Pediatr, 2016 Sep 17; 179. PMID: 27634626    Free PMC article.
FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.
Willem S Lexmond, Jeremy A Goettel, +16 authors, Edda Fiebiger.
J Clin Invest, 2016 Sep 20; 126(10). PMID: 27643438    Free PMC article.
Microbiota, regulatory T cell subsets, and allergic disorders.
Caspar Ohnmacht.
Allergo J Int, 2016 Sep 23; 25(5). PMID: 27656354    Free PMC article.
Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery.
Katherine Nutsch, Jiani N Chai, +4 authors, Chyi-Song Hsieh.
Cell Rep, 2016 Sep 30; 17(1). PMID: 27681432    Free PMC article.
Microbiome and food allergy.
Ana B Blázquez, M Cecilia Berin.
Transl Res, 2016 Oct 01; 179. PMID: 27686718    Free PMC article.
Review.
Kinetic changes of intestinal microbiota in the course of intestinal sensitization.
Liang Xiao, Bo Yang, +5 authors, Ping-Chang Yang.
Oncotarget, 2016 Oct 27; 7(49). PMID: 27783988    Free PMC article.
A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model.
Susanne C Diesner, Cornelia Bergmayr, +14 authors, Eva Untersmayr.
Clin Immunol, 2016 Nov 05; 173. PMID: 27789346    Free PMC article.
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Melanie Schirmer, Sanne P Smeekens, +15 authors, Ramnik J Xavier.
Cell, 2016 Nov 05; 167(4). PMID: 27814509    Free PMC article.
Highly Cited.
Role of the intestinal mucosa in acute gastrointestinal GVHD.
Jonathan U Peled, Alan M Hanash, Robert R Jenq.
Blood, 2016 Nov 20; 128(20). PMID: 27856471    Free PMC article.
Review.
Role of the intestinal mucosa in acute gastrointestinal GVHD.
Jonathan U Peled, Alan M Hanash, Robert R Jenq.
Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913470    Free PMC article.
Review.
Food allergy and the gut.
Anna Nowak-Wegrzyn, Hania Szajewska, Gideon Lack.
Nat Rev Gastroenterol Hepatol, 2016 Dec 22; 14(4). PMID: 27999436
Review.
Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.
Nicholas W Griffin, Philip P Ahern, +5 authors, Jeffrey I Gordon.
Cell Host Microbe, 2017 Jan 04; 21(1). PMID: 28041931    Free PMC article.
Highly Cited.
Diet Matters: Endotoxin in the Diet Impacts the Level of Allergic Sensitization in Germ-Free Mice.
Martin Schwarzer, Dagmar Srutkova, +3 authors, Irma Schabussova.
PLoS One, 2017 Jan 05; 12(1). PMID: 28052076    Free PMC article.
The Influence of the Microbiome on Allergic Sensitization to Food.
Catherine H Plunkett, Cathryn R Nagler.
J Immunol, 2017 Jan 11; 198(2). PMID: 28069753    Free PMC article.
Review.
Examination of high-antibiotic users in a multi-institutional cohort of chronic rhinosinusitis patients.
Vijay R Ramakrishnan, Jess C Mace, Zachary M Soler, Timothy L Smith.
Int Forum Allergy Rhinol, 2017 Jan 14; 7(4). PMID: 28084683    Free PMC article.
Morphogenesis and maturation of the embryonic and postnatal intestine.
Alana M Chin, David R Hill, Megan Aurora, Jason R Spence.
Semin Cell Dev Biol, 2017 Feb 06; 66. PMID: 28161556    Free PMC article.
Review.
Metagenomics approach to the study of the gut microbiome structure and function in zebrafish Danio rerio fed with gluten formulated diet.
Hyunmin Koo, Joseph A Hakim, +7 authors, Asim K Bej.
J Microbiol Methods, 2017 Feb 09; 135. PMID: 28167213    Free PMC article.
Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases.
Lieke Wj van den Elsen, Hazel C Poyntz, +2 authors, Elizabeth E Forbes-Blom.
Clin Transl Immunology, 2017 Feb 16; 6(1). PMID: 28197336    Free PMC article.
Review.
Exopolysaccharide from Bacillus subtilis Induces Anti-Inflammatory M2 Macrophages That Prevent T Cell-Mediated Disease.
Mallory L Paynich, Sara E Jones-Burrage, Katherine L Knight.
J Immunol, 2017 Feb 17; 198(7). PMID: 28202619    Free PMC article.
The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.
Yvonne J Huang, Benjamin J Marsland, +4 authors, Thomas A Fleisher.
J Allergy Clin Immunol, 2017 Mar 05; 139(4). PMID: 28257972    Free PMC article.
Highly Cited. Review.
Beyond Hygiene: Commensal Microbiota and Allergic Diseases.
Sung-Wook Hong, Kwang Soon Kim, Charles D Surh.
Immune Netw, 2017 Mar 07; 17(1). PMID: 28261020    Free PMC article.
Review.
Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation.
W Fonseca, K Lucey, +12 authors, N W Lukacs.
Mucosal Immunol, 2017 Mar 16; 10(6). PMID: 28295020    Free PMC article.
Exploration of the effect of probiotics supplementation on intestinal microbiota of food allergic mice.
Bo Yang, Liang Xiao, +5 authors, Zhigang Liu.
Am J Transl Res, 2017 Mar 25; 9(2). PMID: 28337267    Free PMC article.
Enhanced Probiotic Potential of Lactobacillus reuteri When Delivered as a Biofilm on Dextranomer Microspheres That Contain Beneficial Cargo.
Jason B Navarro, Lauren Mashburn-Warren, +2 authors, Steven D Goodman.
Front Microbiol, 2017 Apr 12; 8. PMID: 28396655    Free PMC article.
TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
Min-Kyung Choo, Yasuyo Sano, +12 authors, Jin Mo Park.
J Exp Med, 2017 Apr 13; 214(5). PMID: 28400473    Free PMC article.
Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens.
Yun-Gi Kim, Kei Sakamoto, +14 authors, Gabriel Núñez.
Science, 2017 Apr 22; 356(6335). PMID: 28428425    Free PMC article.
Highly Cited.
Early life factors that affect allergy development.
Lisa A Reynolds, B Brett Finlay.
Nat Rev Immunol, 2017 May 16; 17(8). PMID: 28504257
Review.
Bacterial colonization and succession in a newly opened hospital.
Simon Lax, Naseer Sangwan, +17 authors, Jack A Gilbert.
Sci Transl Med, 2017 May 26; 9(391). PMID: 28539477    Free PMC article.
Highly Cited.
Multifactorial Modulation of Food-Induced Anaphylaxis.
Sara Benedé, María Garrido-Arandia, +3 authors, Mayte Villalba.
Front Immunol, 2017 Jun 01; 8. PMID: 28559894    Free PMC article.
Review.
Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases.
Sun Hwa Lee, Yun Na Gong, Eell Ryoo.
Korean J Pediatr, 2017 Jun 09; 60(5). PMID: 28592977    Free PMC article.
Acid suppression therapy and allergic reactions.
Eva Untersmayr.
Allergo J Int, 2015 Dec 01; 24(8). PMID: 28603686    Free PMC article.
A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.
Jessica H Savage, Kathleen A Lee-Sarwar, +11 authors, Augusto A Litonjua.
Allergy, 2017 Jun 21; 73(1). PMID: 28632934    Free PMC article.
Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy.
Rosita Aitoro, Lorella Paparo, +9 authors, Roberto Berni Canani.
Nutrients, 2017 Jun 29; 9(7). PMID: 28657607    Free PMC article.
Review.
Pathophysiology of Eosinophilic Esophagitis.
Kelly M O'Shea, Seema S Aceves, +4 authors, Marc E Rothenberg.
Gastroenterology, 2017 Aug 02; 154(2). PMID: 28757265    Free PMC article.
Highly Cited. Review.
Human Milk and Allergic Diseases: An Unsolved Puzzle.
Daniel Munblit, Diego G Peroni, +14 authors, John O Warner.
Nutrients, 2017 Aug 18; 9(8). PMID: 28817095    Free PMC article.
Highly Cited. Review.
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Myles R Minter, Reinhard Hinterleitner, +11 authors, Sangram S Sisodia.
Sci Rep, 2017 Sep 07; 7(1). PMID: 28874832    Free PMC article.
Highly Cited.
How can computation advance microbiome research?
Ruth Nussinov, Jason A Papin.
PLoS Comput Biol, 2017 Sep 22; 13(9). PMID: 28934204    Free PMC article.
Intestinal barrier and gut microbiota: Shaping our immune responses throughout life.
Tatiana Takiishi, Camila Ideli Morales Fenero, Niels Olsen Saraiva Câmara.
Tissue Barriers, 2017 Sep 29; 5(4). PMID: 28956703    Free PMC article.
Review.
Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication.
Goo-Young Seo, Jeong-Min Lee, +7 authors, Pyeung-Hyeun Kim.
Cell Immunol, 2017 Oct 19; 322. PMID: 29042055    Free PMC article.
Dietary Intervention with β-Lactoglobulin-Derived Peptides and a Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates the Prevention of Whey-Induced Allergy in Mice by Supporting a Tolerance-Prone Immune Environment.
Atanaska I Kostadinova, Alba Pablos-Tanarro, +4 authors, Linette E M Willemsen.
Front Immunol, 2017 Nov 11; 8. PMID: 29123515    Free PMC article.
Oral Tolerance Development and Maintenance.
Erik Wambre, David Jeong.
Immunol Allergy Clin North Am, 2017 Nov 15; 38(1). PMID: 29132672    Free PMC article.
Review.
The microbiota protects against respiratory infection via GM-CSF signaling.
Rebecca L Brown, Richard P Sequeira, Thomas B Clarke.
Nat Commun, 2017 Nov 17; 8(1). PMID: 29142211    Free PMC article.
Highly Cited.
Designing synbiotics for improved human health.
Sean M Kearney, Sean M Gibbons.
Microb Biotechnol, 2017 Dec 06; 11(1). PMID: 29205932    Free PMC article.
Microbiome and asthma.
Milena Sokolowska, Remo Frei, +2 authors, Liam O'Mahony.
Asthma Res Pract, 2018 Jan 11; 4. PMID: 29318023    Free PMC article.
Highly Cited. Review.
Pathophysiology of Eosinophilic Esophagitis.
Benjamin P Davis.
Clin Rev Allergy Immunol, 2018 Jan 15; 55(1). PMID: 29332138
Review.
Adaptive immune education by gut microbiota antigens.
Qing Zhao, Charles O Elson.
Immunology, 2018 Jan 18; 154(1). PMID: 29338074    Free PMC article.
Review.
Influence of changes in the intestinal microflora on the immune function in mice.
Shigefumi Kishida, Yuko Kato-Mori, Katsuro Hagiwara.
J Vet Med Sci, 2018 Feb 09; 80(3). PMID: 29415902    Free PMC article.
Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis.
Dong-Wook Hyun, Hyun Jin Min, +9 authors, Jin-Woo Bae.
Infect Immun, 2018 Feb 10; 86(4). PMID: 29426044    Free PMC article.
The nasal microbiome in patients with chronic rhinosinusitis: Analyzing the effects of atopy and bacterial functional pathways in 111 patients.
Mahboobeh Mahdavinia, Phillip A Engen, +12 authors, Pete S Batra.
J Allergy Clin Immunol, 2018 Feb 17; 142(1). PMID: 29452201    Free PMC article.
Mechanisms of Oral Tolerance.
Leticia Tordesillas, M Cecilia Berin.
Clin Rev Allergy Immunol, 2018 Mar 01; 55(2). PMID: 29488131    Free PMC article.
Review.
Regulation of Allergic Immune Responses by Microbial Metabolites.
Hyun Jung Park, Sung Won Lee, Seokmann Hong.
Immune Netw, 2018 Mar 06; 18(1). PMID: 29503745    Free PMC article.
Review.
Narrow-Spectrum Antibacterial Agents.
Roberta J Melander, Daniel V Zurawski, Christian Melander.
Medchemcomm, 2018 Mar 13; 9. PMID: 29527285    Free PMC article.
Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood.
Edward Mitre, Apryl Susi, +3 authors, Cade M Nylund.
JAMA Pediatr, 2018 Apr 04; 172(6). PMID: 29610864    Free PMC article.
Highly Cited.
Role of the Microbiome in Food Allergy.
Hsi-En Ho, Supinda Bunyavanich.
Curr Allergy Asthma Rep, 2018 Apr 07; 18(4). PMID: 29623445
Review.
Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective.
Ravichandra Vemuri, Rohit Gundamaraju, +7 authors, Rajaraman Eri.
Biomed Res Int, 2018 Apr 24; 2018. PMID: 29682542    Free PMC article.
Review.
Pharmacomicrobiomics: a novel route towards personalized medicine?
Marwah Doestzada, Arnau Vich Vila, +6 authors, Jingyuan Fu.
Protein Cell, 2018 May 01; 9(5). PMID: 29705929    Free PMC article.
Review.
Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells.
Hugo A Penny, Suzanne H Hodge, Matthew R Hepworth.
Semin Immunopathol, 2018 May 09; 40(4). PMID: 29737384    Free PMC article.
Review.
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Marlies Meisel, Reinhard Hinterleitner, +28 authors, Bana Jabri.
Nature, 2018 May 18; 557(7706). PMID: 29769727    Free PMC article.
Highly Cited.
Microbiome in patients with upper airway disease: Moving from taxonomic findings to mechanisms and causality.
Vijay R Ramakrishnan, Daniel N Frank.
J Allergy Clin Immunol, 2018 May 29; 142(1). PMID: 29803801    Free PMC article.
Hepatic Mitochondrial Dysfunction and Immune Response in a Murine Model of Peanut Allergy.
Giovanna Trinchese, Lorella Paparo, +5 authors, Roberto Berni Canani.
Nutrients, 2018 Jun 13; 10(6). PMID: 29890625    Free PMC article.
Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota.
Sean M Kearney, Sean M Gibbons, +5 authors, Eric J Alm.
ISME J, 2018 Jun 15; 12(10). PMID: 29899513    Free PMC article.
Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut.
Aspen T Reese, Eugenia H Cho, +11 authors, Lawrence A David.
Elife, 2018 Jun 20; 7. PMID: 29916366    Free PMC article.
Influence of microbiome and diet on immune responses in food allergy models.
Weronika Barcik, Eva Untersmayr, +2 authors, Remo Frei.
Drug Discov Today Dis Models, 2015 Jan 01; 17-18. PMID: 29967644    Free PMC article.
Enhancing the Safety and Efficacy of Food Allergy Immunotherapy: a Review of Adjunctive Therapies.
Yamini V Virkud, Julie Wang, Wayne G Shreffler.
Clin Rev Allergy Immunol, 2018 Jul 04; 55(2). PMID: 29968170
Review.
The Role of the Environment in Eosinophilic Esophagitis.
Paul J Dowling, Hannah Neuhaus, Brooke I Polk.
Clin Rev Allergy Immunol, 2018 Jul 23; 57(3). PMID: 30032346
Review.
Hematopoietic reconstitution of neonatal immunocompetent mice to study conditions with a perinatal window of susceptibility.
Karen Laky, Philip Dugan, Pamela A Frischmeyer-Guerrerio.
Sci Rep, 2018 Aug 18; 8(1). PMID: 30115970    Free PMC article.
Immunologically Active Components in Human Milk and Development of Atopic Disease, With Emphasis on Food Allergy, in the Pediatric Population.
Puja S Rajani, Antti E Seppo, Kirsi M Järvinen.
Front Pediatr, 2018 Aug 23; 6. PMID: 30131949    Free PMC article.
Review.
The Effect of Digestion and Digestibility on Allergenicity of Food.
Isabella Pali-Schöll, Eva Untersmayr, Martina Klems, Erika Jensen-Jarolim.
Nutrients, 2018 Aug 24; 10(9). PMID: 30134536    Free PMC article.
Review.
The Intestinal Virome and Immunity.
Jessica A Neil, Ken Cadwell.
J Immunol, 2018 Sep 06; 201(6). PMID: 30181300    Free PMC article.
Review.
Experimental Models for Studying Food Allergy.
Cynthia Kanagaratham, Benjamin F Sallis, Edda Fiebiger.
Cell Mol Gastroenterol Hepatol, 2018 Sep 06; 6(3). PMID: 30182049    Free PMC article.
Review.
Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders.
Elizabeth J Hait, Douglas R McDonald.
Clin Rev Allergy Immunol, 2018 Sep 13; 57(2). PMID: 30206783
Review.
TLR Activation and Allergic Disease: Early Life Microbiome and Treatment.
Kathryn R Michels, Nicholas W Lukacs, Wendy Fonseca.
Curr Allergy Asthma Rep, 2018 Sep 28; 18(11). PMID: 30259206
Review.
Adjuvanted Immunotherapy Approaches for Peanut Allergy.
Brandi T Johnson-Weaver, Herman F Staats, A Wesley Burks, Michael D Kulis.
Front Immunol, 2018 Oct 16; 9. PMID: 30319619    Free PMC article.
Review.
Gut Mucosal Antibody Responses and Implications for Food Allergy.
Ramona A Hoh, Scott D Boyd.
Front Immunol, 2018 Oct 16; 9. PMID: 30319658    Free PMC article.
Review.
Perinatal antibiotic exposure alters composition of murine gut microbiota and may influence later responses to peanut antigen.
Rozlyn C T Boutin, Zach Dwyer, +3 authors, Shawn Hayley.
Allergy Asthma Clin Immunol, 2018 Nov 10; 14. PMID: 30410548    Free PMC article.
Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria.
Elizabeth A Kennedy, Katherine Y King, Megan T Baldridge.
Front Physiol, 2018 Nov 16; 9. PMID: 30429801    Free PMC article.
Highly Cited. Review.
Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function.
Shiyang Li, John W Bostick, +5 authors, Liang Zhou.
Immunity, 2018 Nov 18; 49(5). PMID: 30446384    Free PMC article.
Highly Cited.
Solid Food Introduction and the Development of Food Allergies.
Carlo Caffarelli, Dora Di Mauro, +3 authors, Giampaolo Ricci.
Nutrients, 2018 Nov 21; 10(11). PMID: 30453619    Free PMC article.
Review.
Recent advances in understanding and preventing peanut and tree nut hypersensitivity.
Ayan Kusari, Allison Han, Lawrence Eichenfield.
F1000Res, 2018 Nov 24; 7. PMID: 30467518    Free PMC article.
Review.
Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants.
Bing Ma, Elias McComb, +6 authors, Rose M Viscardi.
Front Microbiol, 2018 Nov 30; 9. PMID: 30487786    Free PMC article.
In the ZOne: How Impedance Facilitates Progress in Functional Dyspepsia Research.
Simon Keely, Nicholas J Talley.
Dig Dis Sci, 2019 Mar 20; 64(11). PMID: 30887149
Gut microbiota from infant with cow's milk allergy promotes clinical and immune features of atopy in a murine model.
Aurélie Mauras, Harm Wopereis, +15 authors, Anne-Judith Waligora-Dupriet.
Allergy, 2019 Mar 20; 74(9). PMID: 30887528    Free PMC article.
Regulation of oral immune tolerance by the microbiome in food allergy.
Emmanuel Stephen-Victor, Talal A Chatila.
Curr Opin Immunol, 2019 Jul 16; 60. PMID: 31302570    Free PMC article.
Review.
Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile-Young Adult Rats.
Janyerkye Tulyeu, Hideki Kumagai, +6 authors, Takanori Yamagata.
Microorganisms, 2019 Oct 19; 7(10). PMID: 31623229    Free PMC article.
Herbal Formula-3 ameliorates OVA-induced food allergy in mice may via modulating the gut microbiota.
Sheng Liu, Bo Yang, Pingchang Yang, Zhigang Liu.
Am J Transl Res, 2019 Oct 22; 11(9). PMID: 31632550    Free PMC article.
Primary Prevention of Cow's Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow's Milk Formula at Birth: A Randomized Clinical Trial.
Mitsuyoshi Urashima, Hidetoshi Mezawa, +4 authors, Hiroshi Tachimoto.
JAMA Pediatr, 2019 Oct 22; 173(12). PMID: 31633778    Free PMC article.
Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome.
Ziying Zhang, Haosheng Tang, +2 authors, Yongguang Tao.
Signal Transduct Target Ther, 2019 Oct 23; 4. PMID: 31637019    Free PMC article.
Review.
A decreased abundance of clostridia characterizes the gut microbiota in eosinophilic esophagitis.
Purna C Kashyap, Stephen Johnson, +5 authors, David A Katzka.
Physiol Rep, 2019 Oct 28; 7(20). PMID: 31650712    Free PMC article.
Immune Activation in Functional Gastrointestinal Disorders.
Grace Burns, Jennifer Pryor, +3 authors, Simon Keely.
Gastroenterol Hepatol (N Y), 2019 Dec 06; 15(10). PMID: 31802978    Free PMC article.
Food allergy and the microbiome: Current understandings and future directions.
Supinda Bunyavanich, M Cecilia Berin.
J Allergy Clin Immunol, 2019 Dec 10; 144(6). PMID: 31812181    Free PMC article.
Review.
Microbial interactions in the atopic march.
B Nibbering, N D J Ubags.
Clin Exp Immunol, 2019 Nov 30; 199(1). PMID: 31777060    Free PMC article.
Review.
'Layered immunity' and the 'neonatal window of opportunity' - timed succession of non-redundant phases to establish mucosal host-microbial homeostasis after birth.
Mathias W Hornef, Natalia Torow.
Immunology, 2019 Nov 30; 159(1). PMID: 31777069    Free PMC article.
Review.
Oesophageal eosinophilia accompanies food allergy to hen egg white protein in young pigs.
Nathalie J Plundrich, Andrew R Smith, +7 authors, Scott M Laster.
Clin Exp Allergy, 2019 Nov 09; 50(1). PMID: 31702085    Free PMC article.
Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis.
Shohei Matsui, Hideo Kataoka, +10 authors, Hirotaka Kuwata.
Infect Immun, 2019 Oct 16; 88(1). PMID: 31611274    Free PMC article.
Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis.
Shashi P Singh, Hitendra S Chand, +4 authors, Mohan Sopori.
Dig Dis Sci, 2019 Oct 24; 65(1). PMID: 31643033    Free PMC article.
Recent developments in understanding the mechanisms of food allergy.
Zoe C Schmiechen, Katherine A Weissler, Pamela A Frischmeyer-Guerrerio.
Curr Opin Pediatr, 2019 Nov 07; 31(6). PMID: 31693591    Free PMC article.
Review.
Dietary Patterns Impact Temporal Dynamics of Fecal Microbiota Composition in Children With Autism Spectrum Disorder.
Kirsten Berding, Sharon M Donovan.
Front Nutr, 2020 Jan 31; 6. PMID: 31998741    Free PMC article.
Using Precisely Defined in vivo Microbiotas to Understand Microbial Regulation of IgE.
Madeleine Wyss, Kirsty Brown, +8 authors, Kathy D McCoy.
Front Immunol, 2020 Feb 06; 10. PMID: 32010146    Free PMC article.
Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis.
Karin Ried.
Exp Ther Med, 2020 Feb 06; 19(2). PMID: 32010325    Free PMC article.
The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review.
María Dolores Mesa, Begoña Loureiro, +26 authors, Fernando Cabañas.
Nutrients, 2020 Jan 08; 12(1). PMID: 31906588    Free PMC article.
Review.
Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity.
Rodrigo Jiménez-Saiz, Varun C Anipindi, +13 authors, Manel Jordana.
Front Immunol, 2020 Mar 03; 11. PMID: 32117293    Free PMC article.
Early-life gut microbiome and egg allergy.
M Fazlollahi, Y Chun, +8 authors, S Bunyavanich.
Allergy, 2018 Jan 11; 73(7). PMID: 29318631    Free PMC article.
A Summary of the Third Annual HIV Microbiome Workshop.
Brett Williams, Charles Boucher, +11 authors, Alan Landay.
AIDS Res Hum Retroviruses, 2018 Aug 15; 34(10). PMID: 30105916    Free PMC article.
The gut microbiome in food allergy.
William Zhao, Hsi-En Ho, Supinda Bunyavanich.
Ann Allergy Asthma Immunol, 2018 Dec 24; 122(3). PMID: 30578857    Free PMC article.
Review.
Healthy infants harbor intestinal bacteria that protect against food allergy.
Taylor Feehley, Catherine H Plunkett, +11 authors, Cathryn R Nagler.
Nat Med, 2019 Jan 16; 25(3). PMID: 30643289    Free PMC article.
Highly Cited.
Utilizing longitudinal microbiome taxonomic profiles to predict food allergy via Long Short-Term Memory networks.
Ahmed A Metwally, Philip S Yu, +3 authors, David L Perkins.
PLoS Comput Biol, 2019 Feb 05; 15(2). PMID: 30716085    Free PMC article.
Mechanisms that define transient versus persistent food allergy.
M Cecilia Berin.
J Allergy Clin Immunol, 2019 Feb 10; 143(2). PMID: 30736894    Free PMC article.
Review.
Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy.
Martin Schwarzer, Petra Hermanova, +9 authors, Irma Schabussova.
Front Immunol, 2019 Feb 28; 10. PMID: 30809227    Free PMC article.
Gut Microbiome as Target for Innovative Strategies Against Food Allergy.
Roberto Berni Canani, Lorella Paparo, +7 authors, Danilo Ercolini.
Front Immunol, 2019 Mar 05; 10. PMID: 30828329    Free PMC article.
Review.
Microbial Adjuncts for Food Allergen Immunotherapy.
Hsi-En Ho, Supinda Bunyavanich.
Curr Allergy Asthma Rep, 2019 Mar 25; 19(5). PMID: 30903301
Review.
In Vitro and In Vivo Activities of Zinc Linolenate, a Selective Antibacterial Agent against Helicobacter pylori.
Yanqiang Huang, Xudong Hang, +5 authors, Hongkai Bi.
Antimicrob Agents Chemother, 2019 Apr 03; 63(6). PMID: 30936098    Free PMC article.
Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity.
Lishan Li, Shitao Rao, +5 authors, Li Yang.
Microbiologyopen, 2019 Apr 20; 8(8). PMID: 31001921    Free PMC article.
Review.
Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota.
Sung-Wook Hong, Eunju O, +6 authors, Kwang Soon Kim.
Sci Adv, 2019 May 28; 5(5). PMID: 31131325    Free PMC article.
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy.
Azza Abdel-Gadir, Emmanuel Stephen-Victor, +15 authors, Talal A Chatila.
Nat Med, 2019 Jun 27; 25(7). PMID: 31235962    Free PMC article.
Highly Cited.
Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?
Laure Castan, Katrine L Bøgh, +14 authors, Shanna Bastiaan-Net.
Allergy, 2019 Jun 13; 75(2). PMID: 31187876    Free PMC article.
Review.
Calorie restriction and its impact on gut microbial composition and global metabolism.
Xiaojiao Zheng, Shouli Wang, Wei Jia.
Front Med, 2018 Nov 18; 12(6). PMID: 30446879
Review.
Influences on allergic mechanisms through gut, lung, and skin microbiome exposures.
Andrea M Kemter, Cathryn R Nagler.
J Clin Invest, 2019 Mar 05; 129(4). PMID: 30830878    Free PMC article.
Review.
Mechanisms of gastrointestinal allergic disorders.
Nurit P Azouz, Marc E Rothenberg.
J Clin Invest, 2019 Mar 12; 129(4). PMID: 30855279    Free PMC article.
Review.
Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings.
Suprabhat Mukherjee, Nikhilesh Joardar, Subhasree Sengupta, Santi P Sinha Babu.
J Nutr Biochem, 2018 Sep 10; 61. PMID: 30196243    Free PMC article.
Review.
The gut microbiota, environmental factors, and links to the development of food allergy.
Khui Hung Lee, Yong Song, +2 authors, Guicheng Zhang.
Clin Mol Allergy, 2020 Apr 09; 18. PMID: 32265597    Free PMC article.
Review.
In sickness and health: Effects of gut microbial metabolites on human physiology.
Robert W P Glowacki, Eric C Martens.
PLoS Pathog, 2020 Apr 10; 16(4). PMID: 32271839    Free PMC article.
Innate Lymphoid Cells in Mucosal Immunity.
Santosh K Panda, Marco Colonna.
Front Immunol, 2019 May 28; 10. PMID: 31134050    Free PMC article.
Review.
Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy.
Takashi Fujimura, Shelly Zing Chin Lum, +2 authors, Michiko K Oyoshi.
Front Immunol, 2019 Sep 12; 10. PMID: 31507589    Free PMC article.
Review.
Drugging the microbiome.
Cathryn R Nagler.
J Exp Med, 2020 Mar 10; 217(4). PMID: 32150223    Free PMC article.
Microbiome Composition and Its Impact on the Development of Allergic Diseases.
Diego G Peroni, Giulia Nuzzi, +2 authors, Pasquale Comberiati.
Front Immunol, 2020 May 12; 11. PMID: 32391012    Free PMC article.
Review.
Impact of antimicrobial therapy on the gut microbiome.
Amira A Bhalodi, Tjitske S R van Engelen, Harjeet S Virk, W Joost Wiersinga.
J Antimicrob Chemother, 2019 Jan 29; 74(Suppl 1). PMID: 30690540    Free PMC article.
Highly Cited. Review.
The Effects of Low-Nickel Diet Combined with Oral Administration of Selected Probiotics on Patients with Systemic Nickel Allergy Syndrome (SNAS) and Gut Dysbiosis.
Francesca Lombardi, Fabiana Fiasca, +6 authors, Mauro Minelli.
Nutrients, 2020 Apr 15; 12(4). PMID: 32283870    Free PMC article.
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes.
Hemraj B Dodiya, Thomas Kuntz, +8 authors, Sangram S Sisodia.
J Exp Med, 2019 May 18; 216(7). PMID: 31097468    Free PMC article.
Highly Cited.
Dietary AhR Ligands Regulate AhRR Expression in Intestinal Immune Cells and Intestinal Microbiota Composition.
Oliver Schanz, Rieka Chijiiwa, +4 authors, Irmgard Förster.
Int J Mol Sci, 2020 May 06; 21(9). PMID: 32366032    Free PMC article.
Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites.
Michael W Dougherty, Oleksandr Kudin, +3 authors, Christian Jobin.
BMC Microbiol, 2020 Jul 13; 20(1). PMID: 32652929    Free PMC article.
In Vitro Fermentation of Sheep and Cow Milk Using Infant Fecal Bacteria.
Natalie Ahlborn, Wayne Young, Jane Mullaney, Linda M Samuelsson.
Nutrients, 2020 Jun 21; 12(6). PMID: 32560419    Free PMC article.
The human gut microbiome in health: establishment and resilience of microbiota over a lifetime.
Kacy Greenhalgh, Kristen M Meyer, Kjersti M Aagaard, Paul Wilmes.
Environ Microbiol, 2016 Apr 10; 18(7). PMID: 27059297    Free PMC article.
Review.
Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications.
Peter Capucilli, David A Hill.
Clin Rev Allergy Immunol, 2019 Mar 25; 57(1). PMID: 30903437    Free PMC article.
Review.
Recent advances in mechanisms of food allergy and anaphylaxis.
Sunil Tomar, Simon P Hogan.
F1000Res, 2020 Aug 14; 9. PMID: 32789004    Free PMC article.
Review.
Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?
Matteo Puccetti, Styliani Xiroudaki, Maurizio Ricci, Stefano Giovagnoli.
Pharmaceutics, 2020 Jul 09; 12(7). PMID: 32635461    Free PMC article.
Review.
Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies.
Margherita Di Costanzo, Laura Carucci, Roberto Berni Canani, Giacomo Biasucci.
Int J Mol Sci, 2020 Jul 30; 21(15). PMID: 32722378    Free PMC article.
Review.
Primary Prevention of Allergic Diseases: The Role of Early Exposure to Cow's Milk Formula.
Carla Mastrorilli, Angelica Santoro, Carlo Caffarelli.
Front Pediatr, 2020 Aug 28; 8. PMID: 32850536    Free PMC article.
Review.
Synchronization of mothers and offspring promotes tolerance and limits allergy.
Kathryn A Knoop, Keely G McDonald, +13 authors, Rodney D Newberry.
JCI Insight, 2020 Aug 08; 5(15). PMID: 32759496    Free PMC article.
In the Age of Synthetic Biology, Will Antimicrobial Peptides be the Next Generation of Antibiotics?
Félix Jaumaux, Luz P Gómez de Cadiñanos, Philippe Gabant.
Antibiotics (Basel), 2020 Aug 13; 9(8). PMID: 32781540    Free PMC article.
Dietary and Microbial Determinants in Food Allergy.
Emmanuel Stephen-Victor, Elena Crestani, Talal A Chatila.
Immunity, 2020 Aug 20; 53(2). PMID: 32814026    Free PMC article.
Review.
Therapeutic Potential of the Intestinal Microbiota for Immunomodulation of Food Allergies.
Luisa Kreft, Christian Hoffmann, Caspar Ohnmacht.
Front Immunol, 2020 Sep 15; 11. PMID: 32922400    Free PMC article.
Review.
The Effect of Kyolic Aged Garlic Extract on Gut Microbiota, Inflammation, and Cardiovascular Markers in Hypertensives: The GarGIC Trial.
Karin Ried, Nikolaj Travica, Avni Sali.
Front Nutr, 2019 Jan 09; 5. PMID: 30619868    Free PMC article.
Shaping the Gut Microbiota by Breastfeeding: The Gateway to Allergy Prevention?
Lieke W J van den Elsen, Johan Garssen, Remy Burcelin, Valerie Verhasselt.
Front Pediatr, 2019 Mar 16; 7. PMID: 30873394    Free PMC article.
Highly Cited. Review.
Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies.
Chih-Yung Chiu, Yi-Ling Chan, +3 authors, Chun-Che Chiu.
World Allergy Organ J, 2019 Apr 03; 12(3). PMID: 30937143    Free PMC article.
Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers.
Katharina Anne Scherf, Ann-Christin Lindenau, +7 authors, Knut Brockow.
Clin Transl Allergy, 2019 Apr 10; 9. PMID: 30962874    Free PMC article.
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Wenjing Yang, Tianming Yu, +13 authors, Yingzi Cong.
Nat Commun, 2020 Sep 10; 11(1). PMID: 32901017    Free PMC article.
Exercise immunology: Future directions.
David C Nieman, Brandt D Pence.
J Sport Health Sci, 2020 Sep 16; 9(5). PMID: 32928447    Free PMC article.
Review.
Microbiome of root vegetables-a source of gluten-degrading bacteria.
Viia Kõiv, Kaarel Adamberg, +5 authors, Tanel Tenson.
Appl Microbiol Biotechnol, 2020 Sep 03; 104(20). PMID: 32875365    Free PMC article.
Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology.
Matthew C Altman, Avraham Beigelman, +10 authors, R Stokes Peebles.
J Allergy Clin Immunol, 2020 Jan 12; 145(5). PMID: 31926183    Free PMC article.
Probiotics: Versatile Bioactive Components in Promoting Human Health.
Javad Sharifi-Rad, Célia F Rodrigues, +11 authors, Daniela Calina.
Medicina (Kaunas), 2020 Sep 02; 56(9). PMID: 32867260    Free PMC article.
Review.
Microbial signature in IgE-mediated food allergies.
Michael R Goldberg, Hadar Mor, +10 authors, Omry Koren.
Genome Med, 2020 Oct 29; 12(1). PMID: 33109272    Free PMC article.
Stool microbiome, pH and short/branched chain fatty acids in infants receiving extensively hydrolyzed formula, amino acid formula, or human milk through two months of age.
Car Reen Kok, Bradford Brabec, +6 authors, Robert Hutkins.
BMC Microbiol, 2020 Nov 11; 20(1). PMID: 33167908    Free PMC article.
The microbiome and its impact on food allergy and atopic dermatitis in children.
Ewa Łoś-Rycharska, Marcin Gołębiewski, +2 authors, Aneta Krogulska.
Postepy Dermatol Alergol, 2020 Nov 27; 37(5). PMID: 33240001    Free PMC article.
Review.
The role of commensal bacteria in the regulation of sensitization to food allergens.
Severine Cao, Taylor J Feehley, Cathryn R Nagler.
FEBS Lett, 2014 May 06; 588(22). PMID: 24791655    Free PMC article.
Review.
A Summary of the First HIV Microbiome Workshop 2015.
Brett Williams, Paria Mirmonsef, +9 authors, Alan Landay.
AIDS Res Hum Retroviruses, 2016 Jun 09; 32(10-11). PMID: 27267576    Free PMC article.
Hygiene factors associated with childhood food allergy and asthma.
Ruchi S Gupta, Anne Marie Singh, +5 authors, Bridget M Smith.
Allergy Asthma Proc, 2016 Dec 10; 37(6). PMID: 27931290    Free PMC article.
Mechanisms by which gut microorganisms influence food sensitivities.
Alberto Caminero, Marlies Meisel, Bana Jabri, Elena F Verdu.
Nat Rev Gastroenterol Hepatol, 2018 Sep 15; 16(1). PMID: 30214038    Free PMC article.
Review.
Microbiota and Food Allergy.
Shang-An Shu, Agatha W T Yuen, +5 authors, Patrick S C Leung.
Clin Rev Allergy Immunol, 2018 Dec 20; 57(1). PMID: 30564985
Review.
Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice.
Pernille Kihl, Lukasz Krych, +7 authors, Axel Kornerup Hansen.
J Diabetes Res, 2019 Apr 09; 2019. PMID: 30956991    Free PMC article.
Microbial ambassadors against food allergies.
Michael Eisenstein.
Nature, 2020 Dec 04; 588(7836). PMID: 33268856
The Gut Microbiome and the Big Eight.
Cassandra Suther, Matthew D Moore, Avraham Beigelman, Yanjiao Zhou.
Nutrients, 2020 Dec 09; 12(12). PMID: 33287179    Free PMC article.
Review.
Oxygen and Metabolism: Digesting Determinants of Antibiotic Susceptibility in the Gut.
Lauren R Heinzinger, Angus Johnson, +3 authors, Peter Belenky.
iScience, 2020 Dec 24; 23(12). PMID: 33354661    Free PMC article.
Review.
IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy.
Cynthia Kanagaratham, Yasmeen S El Ansari, Owen L Lewis, Hans C Oettgen.
Front Immunol, 2020 Dec 29; 11. PMID: 33362785    Free PMC article.
Review.
Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy.
Ayesha Ali, HuiYing Tan, Gerard E Kaiko.
Front Immunol, 2020 Dec 29; 11. PMID: 33365031    Free PMC article.
Review.
B cells and the microbiota: a missing connection in food allergy.
Evelyn Campbell, Lauren A Hesser, Cathryn R Nagler.
Mucosal Immunol, 2020 Oct 28; 14(1). PMID: 33106585
Review.
Fecal microbiome and metabolome differ in healthy and food-allergic twins.
Riyue Bao, Lauren A Hesser, +3 authors, Cathryn R Nagler.
J Clin Invest, 2021 Jan 20; 131(2). PMID: 33463536    Free PMC article.
Dysbiosis in food allergy and implications for microbial therapeutics.
M Cecilia Berin.
J Clin Invest, 2021 Jan 20; 131(2). PMID: 33463542    Free PMC article.
Antigen-Presenting Cells in Food Tolerance and Allergy.
Elise G Liu, Xiangyun Yin, Anush Swaminathan, Stephanie C Eisenbarth.
Front Immunol, 2021 Jan 26; 11. PMID: 33488627    Free PMC article.
Review.
Intestinal Regulatory T Cells.
Vanessa R Figliuolo da Paz, Deepa R Jamwal, Pawel R Kiela.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523448
Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice.
Johanna M Smeekens, Brandi T Johnson-Weaver, +11 authors, Michael D Kulis.
Front Immunol, 2021 Feb 06; 11. PMID: 33542716    Free PMC article.
Regulatory T Cells Developing Peri-Weaning Are Continually Required to Restrain Th2 Systemic Responses Later in Life.
Kathryn A Knoop, Keely G McDonald, +2 authors, Rodney D Newberry.
Front Immunol, 2021 Feb 23; 11. PMID: 33613522    Free PMC article.
Early life microbial exposures and allergy risks: opportunities for prevention.
Harald Renz, Chrysanthi Skevaki.
Nat Rev Immunol, 2020 Sep 13; 21(3). PMID: 32918062
Review.
In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori.
Lufeng Zhang, Liang Zhang, +7 authors, Weihong Tan.
Nat Commun, 2021 Apr 02; 12(1). PMID: 33790299    Free PMC article.
Food allergy: an updated review on pathogenesis, diagnosis, prevention and management.
Mauro Calvani, Caterina Anania, +10 authors, Gian Luigi Marseglia.
Acta Biomed, 2020 Oct 03; 91(11-S). PMID: 33004782    Free PMC article.
Review.
Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice.
Taeko K Noah, Jee-Boong Lee, +7 authors, Simon P Hogan.
Front Immunol, 2021 Apr 13; 12. PMID: 33841417    Free PMC article.
Tissues: the unexplored frontier of antibody mediated immunity.
Nicholas E Webb, Biana Bernshtein, Galit Alter.
Curr Opin Virol, 2021 Feb 14; 47. PMID: 33581646    Free PMC article.
Review.
The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life.
Mariusz Kaczmarczyk, Ulrike Löber, +8 authors, Beata Łoniewska.
J Transl Med, 2021 Apr 30; 19(1). PMID: 33910577    Free PMC article.
The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?
Pei Han, Jian-Qing Gu, +5 authors, Jin-Lyu Sun.
Front Cell Infect Microbiol, 2021 May 04; 11. PMID: 33937097    Free PMC article.
Review.
The microbial origins of food allergy.
Rima Rachid, Emmanuel Stephen-Victor, Talal A Chatila.
J Allergy Clin Immunol, 2020 Dec 22; 147(3). PMID: 33347905    Free PMC article.
Review.
Anti-Allergic Diarrhea Effect of Diosgenin Occurs via Improving Gut Dysbiosis in a Murine Model of Food Allergy.
Chung-Hsiung Huang, Chorng-Liang Pan, +3 authors, Shueh-Yu Lu.
Molecules, 2021 May 01; 26(9). PMID: 33922675    Free PMC article.
Association Between Microbiota and Nasal Mucosal Diseases in terms of Immunity.
Junhu Tai, Mun Soo Han, Jiwon Kwak, Tae Hoon Kim.
Int J Mol Sci, 2021 May 06; 22(9). PMID: 33947066    Free PMC article.
Review.
Host-microbiota interactions in immune-mediated diseases.
William E Ruff, Teri M Greiling, Martin A Kriegel.
Nat Rev Microbiol, 2020 May 28; 18(9). PMID: 32457482
Review.
Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria?
Steve M D'Souza, Kevin Houston, +3 authors, David A Johnson.
World J Gastroenterol, 2021 May 25; 27(18). PMID: 34025064    Free PMC article.
Review.
A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study.
Ewa Łoś-Rycharska, Marcin Gołębiewski, +5 authors, Aneta Krogulska.
Nutrients, 2021 Jun 03; 13(5). PMID: 34063398    Free PMC article.
Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns.
Domenico Gargano, Ramapraba Appanna, +5 authors, Paola Iovino.
Nutrients, 2021 Jun 03; 13(5). PMID: 34068047    Free PMC article.
Review.
Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes.
Cui Zhou, Ling-Ling Chen, +2 authors, Rong Xiao.
Front Immunol, 2021 Jun 29; 12. PMID: 34177885    Free PMC article.
House dust mite sensitization, eczema, and wheeze increase risk of shellfish sensitization.
Evelyn Xiu Ling Loo, Hui Xing Lau, +11 authors, Elizabeth Huiwen Tham.
Pediatr Allergy Immunol, 2021 Mar 10; 32(5). PMID: 33687761    Free PMC article.
Multidimensional study of the oral microbiome, metabolite, and immunologic environment in peanut allergy.
Hsi-En Ho, Yoojin Chun, +3 authors, Supinda Bunyavanich.
J Allergy Clin Immunol, 2021 Apr 06; 148(2). PMID: 33819506    Free PMC article.
Broccoli Florets Supplementation Improves Insulin Sensitivity and Alters Gut Microbiome Population-A Steatosis Mice Model Induced by High-Fat Diet.
Gil Zandani, Sarit Anavi-Cohen, +3 authors, Zecharia Madar.
Front Nutr, 2021 Aug 17; 8. PMID: 34395490    Free PMC article.
Advances in the Relationships Between Cow's Milk Protein Allergy and Gut Microbiota in Infants.
Yudie Yang, Xiaoqi Li, +4 authors, Yongjun Wei.
Front Microbiol, 2021 Sep 07; 12. PMID: 34484158    Free PMC article.
Review.
Partially Hydrolysed Whey Has Superior Allergy Preventive Capacity Compared to Intact Whey Regardless of Amoxicillin Administration in Brown Norway Rats.
Katrine Bækby Graversen, Jeppe Madura Larsen, +7 authors, Katrine Lindholm Bøgh.
Front Immunol, 2021 Sep 18; 12. PMID: 34531857    Free PMC article.
Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies.
Suresh C Bokoliya, Yair Dorsett, Hunter Panier, Yanjiao Zhou.
Front Cell Infect Microbiol, 2021 Oct 09; 11. PMID: 34621688    Free PMC article.
Review.
Specific gut microbiome signatures and the associated pro-inflamatory functions are linked to pediatric allergy and acquisition of immune tolerance.
Francesca De Filippis, Lorella Paparo, +6 authors, Roberto Berni Canani.
Nat Commun, 2021 Oct 15; 12(1). PMID: 34645820    Free PMC article.
Controlled Complexity: Optimized Systems to Study the Role of the Gut Microbiome in Host Physiology.
Robert W P Glowacki, Morgan J Engelhart, Philip P Ahern.
Front Microbiol, 2021 Oct 15; 12. PMID: 34646255    Free PMC article.
Review.
Immunogenetic, Molecular and Microbiotic Determinants of Eosinophilic Esophagitis and Clinical Practice-A New Perspective of an Old Disease.
Alina Kanikowska, Szymon Hryhorowicz, +7 authors, Iwona Krela-Kaźmierczak.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639170    Free PMC article.
Review.
Antibiotic-Induced Gut Microbiota Dysbiosis Damages the Intestinal Barrier, Increasing Food Allergy in Adult Mice.
Qiuyu Zhang, Lei Cheng, +2 authors, Huilian Che.
Nutrients, 2021 Oct 24; 13(10). PMID: 34684316    Free PMC article.
Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome.
Chongyu Zhang, Chen Zhang, +3 authors, Yunkyoung Lee.
Front Vet Sci, 2021 Oct 26; 8. PMID: 34692802    Free PMC article.
Oscillospira - a candidate for the next-generation probiotics.
Jingpeng Yang, Yanan Li, +3 authors, He Huang.
Gut Microbes, 2021 Oct 26; 13(1). PMID: 34693878    Free PMC article.
Escherichia coli Nissle 1917 Enhances Innate and Adaptive Immune Responses in a Ciprofloxacin-Treated Defined-Microbiota Piglet Model of Human Rotavirus Infection.
Husheem Michael, Francine C Paim, +8 authors, Anastasia N Vlasova.
mSphere, 2021 Apr 02; 6(2). PMID: 33789939    Free PMC article.
Microbiome of Barrier Organs in Allergy: Who Runs the World? Germs!
Vera Schwierzeck, Claudia Hülpüsch, Matthias Reiger.
Handb Exp Pharmacol, 2021 Jul 07; 268. PMID: 34228203
Review.
Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations.
Jake A Gertie, Biyan Zhang, +8 authors, Stephanie C Eisenbarth.
J Allergy Clin Immunol, 2021 May 30;. PMID: 34051223    Free PMC article.
Broad-Spectrum and Gram-Negative-Targeting Antibiotics Differentially Regulate Antibody Isotype Responses to Injected Vaccines.
Aklilu F Haile, Rachel M Woodfint, +4 authors, Prosper N Boyaka.
Vaccines (Basel), 2021 Nov 28; 9(11). PMID: 34835171    Free PMC article.