Journal Article
. 2014 Aug; 111(36):13145-50.
doi: 10.1073/pnas.1412008111.

Commensal bacteria protect against food allergen sensitization

Andrew T Stefka 1 Taylor Feehley 1 Prabhanshu Tripathi 1 Ju Qiu 2 Kathy McCoy 3 Sarkis K Mazmanian 4 Melissa Y Tjota 5 Goo-Young Seo 1 Severine Cao 1 Betty R Theriault 6 Dionysios A Antonopoulos 7 Liang Zhou 2 Eugene B Chang 5 Yang-Xin Fu 1 Cathryn R Nagler 8 
  • PMID: 25157157
  •     39 References
  •     264 citations


Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selectively colonizing gnotobiotic mice, we demonstrate that the allergy-protective capacity is conferred by a Clostridia-containing microbiota. Microarray analysis of intestinal epithelial cells from gnotobiotic mice revealed a previously unidentified mechanism by which Clostridia regulate innate lymphoid cell function and intestinal epithelial permeability to protect against allergen sensitization. Our findings will inform the development of novel approaches to prevent or treat food allergy based on modulating the composition of the intestinal microbiota.

Keywords: IL-22; barrier; microbiome.

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J Immunol, 2017 Jan 11; 198(2). PMID: 28069753    Free PMC article.
Examination of high-antibiotic users in a multi-institutional cohort of chronic rhinosinusitis patients.
Vijay R Ramakrishnan, Jess C Mace, Zachary M Soler, Timothy L Smith.
Int Forum Allergy Rhinol, 2017 Jan 14; 7(4). PMID: 28084683    Free PMC article.
Morphogenesis and maturation of the embryonic and postnatal intestine.
Alana M Chin, David R Hill, Megan Aurora, Jason R Spence.
Semin Cell Dev Biol, 2017 Feb 06; 66. PMID: 28161556    Free PMC article.
Metagenomics approach to the study of the gut microbiome structure and function in zebrafish Danio rerio fed with gluten formulated diet.
Hyunmin Koo, Joseph A Hakim, +7 authors, Asim K Bej.
J Microbiol Methods, 2017 Feb 09; 135. PMID: 28167213    Free PMC article.
Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases.
Lieke Wj van den Elsen, Hazel C Poyntz, +2 authors, Elizabeth E Forbes-Blom.
Clin Transl Immunology, 2017 Feb 16; 6(1). PMID: 28197336    Free PMC article.
Exopolysaccharide from Bacillus subtilis Induces Anti-Inflammatory M2 Macrophages That Prevent T Cell-Mediated Disease.
Mallory L Paynich, Sara E Jones-Burrage, Katherine L Knight.
J Immunol, 2017 Feb 17; 198(7). PMID: 28202619    Free PMC article.
The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.
Yvonne J Huang, Benjamin J Marsland, +4 authors, Thomas A Fleisher.
J Allergy Clin Immunol, 2017 Mar 05; 139(4). PMID: 28257972    Free PMC article.
Highly Cited. Review.
Beyond Hygiene: Commensal Microbiota and Allergic Diseases.
Sung-Wook Hong, Kwang Soon Kim, Charles D Surh.
Immune Netw, 2017 Mar 07; 17(1). PMID: 28261020    Free PMC article.
Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation.
W Fonseca, K Lucey, +12 authors, N W Lukacs.
Mucosal Immunol, 2017 Mar 16; 10(6). PMID: 28295020    Free PMC article.
Exploration of the effect of probiotics supplementation on intestinal microbiota of food allergic mice.
Bo Yang, Liang Xiao, +5 authors, Zhigang Liu.
Am J Transl Res, 2017 Mar 25; 9(2). PMID: 28337267    Free PMC article.
Enhanced Probiotic Potential of Lactobacillus reuteri When Delivered as a Biofilm on Dextranomer Microspheres That Contain Beneficial Cargo.
Jason B Navarro, Lauren Mashburn-Warren, +2 authors, Steven D Goodman.
Front Microbiol, 2017 Apr 12; 8. PMID: 28396655    Free PMC article.
TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
Min-Kyung Choo, Yasuyo Sano, +12 authors, Jin Mo Park.
J Exp Med, 2017 Apr 13; 214(5). PMID: 28400473    Free PMC article.
Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens.
Yun-Gi Kim, Kei Sakamoto, +14 authors, Gabriel Núñez.
Science, 2017 Apr 22; 356(6335). PMID: 28428425    Free PMC article.
Highly Cited.
Early life factors that affect allergy development.
Lisa A Reynolds, B Brett Finlay.
Nat Rev Immunol, 2017 May 16; 17(8). PMID: 28504257
Bacterial colonization and succession in a newly opened hospital.
Simon Lax, Naseer Sangwan, +17 authors, Jack A Gilbert.
Sci Transl Med, 2017 May 26; 9(391). PMID: 28539477    Free PMC article.
Highly Cited.
Multifactorial Modulation of Food-Induced Anaphylaxis.
Sara Benedé, María Garrido-Arandia, +3 authors, Mayte Villalba.
Front Immunol, 2017 Jun 01; 8. PMID: 28559894    Free PMC article.
Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases.
Sun Hwa Lee, Yun Na Gong, Eell Ryoo.
Korean J Pediatr, 2017 Jun 09; 60(5). PMID: 28592977    Free PMC article.
Acid suppression therapy and allergic reactions.
Eva Untersmayr.
Allergo J Int, 2015 Dec 01; 24(8). PMID: 28603686    Free PMC article.
A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.
Jessica H Savage, Kathleen A Lee-Sarwar, +11 authors, Augusto A Litonjua.
Allergy, 2017 Jun 21; 73(1). PMID: 28632934    Free PMC article.
Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy.
Rosita Aitoro, Lorella Paparo, +9 authors, Roberto Berni Canani.
Nutrients, 2017 Jun 29; 9(7). PMID: 28657607    Free PMC article.
Pathophysiology of Eosinophilic Esophagitis.
Kelly M O'Shea, Seema S Aceves, +4 authors, Marc E Rothenberg.
Gastroenterology, 2017 Aug 02; 154(2). PMID: 28757265    Free PMC article.
Highly Cited. Review.
Human Milk and Allergic Diseases: An Unsolved Puzzle.
Daniel Munblit, Diego G Peroni, +14 authors, John O Warner.
Nutrients, 2017 Aug 18; 9(8). PMID: 28817095    Free PMC article.
Highly Cited. Review.
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Myles R Minter, Reinhard Hinterleitner, +11 authors, Sangram S Sisodia.
Sci Rep, 2017 Sep 07; 7(1). PMID: 28874832    Free PMC article.
Highly Cited.
How can computation advance microbiome research?
Ruth Nussinov, Jason A Papin.
PLoS Comput Biol, 2017 Sep 22; 13(9). PMID: 28934204    Free PMC article.
Intestinal barrier and gut microbiota: Shaping our immune responses throughout life.
Tatiana Takiishi, Camila Ideli Morales Fenero, Niels Olsen Saraiva Câmara.
Tissue Barriers, 2017 Sep 29; 5(4). PMID: 28956703    Free PMC article.
Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication.
Goo-Young Seo, Jeong-Min Lee, +7 authors, Pyeung-Hyeun Kim.
Cell Immunol, 2017 Oct 19; 322. PMID: 29042055    Free PMC article.
Dietary Intervention with β-Lactoglobulin-Derived Peptides and a Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates the Prevention of Whey-Induced Allergy in Mice by Supporting a Tolerance-Prone Immune Environment.
Atanaska I Kostadinova, Alba Pablos-Tanarro, +4 authors, Linette E M Willemsen.
Front Immunol, 2017 Nov 11; 8. PMID: 29123515    Free PMC article.
Oral Tolerance Development and Maintenance.
Erik Wambre, David Jeong.
Immunol Allergy Clin North Am, 2017 Nov 15; 38(1). PMID: 29132672    Free PMC article.
The microbiota protects against respiratory infection via GM-CSF signaling.
Rebecca L Brown, Richard P Sequeira, Thomas B Clarke.
Nat Commun, 2017 Nov 17; 8(1). PMID: 29142211    Free PMC article.
Highly Cited.
Designing synbiotics for improved human health.
Sean M Kearney, Sean M Gibbons.
Microb Biotechnol, 2017 Dec 06; 11(1). PMID: 29205932    Free PMC article.
Microbiome and asthma.
Milena Sokolowska, Remo Frei, +2 authors, Liam O'Mahony.
Asthma Res Pract, 2018 Jan 11; 4. PMID: 29318023    Free PMC article.
Highly Cited. Review.
Pathophysiology of Eosinophilic Esophagitis.
Benjamin P Davis.
Clin Rev Allergy Immunol, 2018 Jan 15; 55(1). PMID: 29332138
Adaptive immune education by gut microbiota antigens.
Qing Zhao, Charles O Elson.
Immunology, 2018 Jan 18; 154(1). PMID: 29338074    Free PMC article.
Influence of changes in the intestinal microflora on the immune function in mice.
Shigefumi Kishida, Yuko Kato-Mori, Katsuro Hagiwara.
J Vet Med Sci, 2018 Feb 09; 80(3). PMID: 29415902    Free PMC article.
Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis.
Dong-Wook Hyun, Hyun Jin Min, +9 authors, Jin-Woo Bae.
Infect Immun, 2018 Feb 10; 86(4). PMID: 29426044    Free PMC article.
The nasal microbiome in patients with chronic rhinosinusitis: Analyzing the effects of atopy and bacterial functional pathways in 111 patients.
Mahboobeh Mahdavinia, Phillip A Engen, +12 authors, Pete S Batra.
J Allergy Clin Immunol, 2018 Feb 17; 142(1). PMID: 29452201    Free PMC article.
Mechanisms of Oral Tolerance.
Leticia Tordesillas, M Cecilia Berin.
Clin Rev Allergy Immunol, 2018 Mar 01; 55(2). PMID: 29488131    Free PMC article.
Regulation of Allergic Immune Responses by Microbial Metabolites.
Hyun Jung Park, Sung Won Lee, Seokmann Hong.
Immune Netw, 2018 Mar 06; 18(1). PMID: 29503745    Free PMC article.
Narrow-Spectrum Antibacterial Agents.
Roberta J Melander, Daniel V Zurawski, Christian Melander.
Medchemcomm, 2018 Mar 13; 9. PMID: 29527285    Free PMC article.
Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood.
Edward Mitre, Apryl Susi, +3 authors, Cade M Nylund.
JAMA Pediatr, 2018 Apr 04; 172(6). PMID: 29610864    Free PMC article.
Highly Cited.
Role of the Microbiome in Food Allergy.
Hsi-En Ho, Supinda Bunyavanich.
Curr Allergy Asthma Rep, 2018 Apr 07; 18(4). PMID: 29623445
Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective.
Ravichandra Vemuri, Rohit Gundamaraju, +7 authors, Rajaraman Eri.
Biomed Res Int, 2018 Apr 24; 2018. PMID: 29682542    Free PMC article.
Pharmacomicrobiomics: a novel route towards personalized medicine?
Marwah Doestzada, Arnau Vich Vila, +6 authors, Jingyuan Fu.
Protein Cell, 2018 May 01; 9(5). PMID: 29705929    Free PMC article.
Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells.
Hugo A Penny, Suzanne H Hodge, Matthew R Hepworth.
Semin Immunopathol, 2018 May 09; 40(4). PMID: 29737384    Free PMC article.
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Marlies Meisel, Reinhard Hinterleitner, +28 authors, Bana Jabri.
Nature, 2018 May 18; 557(7706). PMID: 29769727    Free PMC article.
Highly Cited.
Microbiome in patients with upper airway disease: Moving from taxonomic findings to mechanisms and causality.
Vijay R Ramakrishnan, Daniel N Frank.
J Allergy Clin Immunol, 2018 May 29; 142(1). PMID: 29803801    Free PMC article.
Hepatic Mitochondrial Dysfunction and Immune Response in a Murine Model of Peanut Allergy.
Giovanna Trinchese, Lorella Paparo, +5 authors, Roberto Berni Canani.
Nutrients, 2018 Jun 13; 10(6). PMID: 29890625    Free PMC article.
Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota.
Sean M Kearney, Sean M Gibbons, +5 authors, Eric J Alm.
ISME J, 2018 Jun 15; 12(10). PMID: 29899513    Free PMC article.
Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut.
Aspen T Reese, Eugenia H Cho, +11 authors, Lawrence A David.
Elife, 2018 Jun 20; 7. PMID: 29916366    Free PMC article.
Influence of microbiome and diet on immune responses in food allergy models.
Weronika Barcik, Eva Untersmayr, +2 authors, Remo Frei.
Drug Discov Today Dis Models, 2015 Jan 01; 17-18. PMID: 29967644    Free PMC article.
Enhancing the Safety and Efficacy of Food Allergy Immunotherapy: a Review of Adjunctive Therapies.
Yamini V Virkud, Julie Wang, Wayne G Shreffler.
Clin Rev Allergy Immunol, 2018 Jul 04; 55(2). PMID: 29968170
The Role of the Environment in Eosinophilic Esophagitis.
Paul J Dowling, Hannah Neuhaus, Brooke I Polk.
Clin Rev Allergy Immunol, 2018 Jul 23; 57(3). PMID: 30032346
Hematopoietic reconstitution of neonatal immunocompetent mice to study conditions with a perinatal window of susceptibility.
Karen Laky, Philip Dugan, Pamela A Frischmeyer-Guerrerio.
Sci Rep, 2018 Aug 18; 8(1). PMID: 30115970    Free PMC article.
Immunologically Active Components in Human Milk and Development of Atopic Disease, With Emphasis on Food Allergy, in the Pediatric Population.
Puja S Rajani, Antti E Seppo, Kirsi M Järvinen.
Front Pediatr, 2018 Aug 23; 6. PMID: 30131949    Free PMC article.
The Effect of Digestion and Digestibility on Allergenicity of Food.
Isabella Pali-Schöll, Eva Untersmayr, Martina Klems, Erika Jensen-Jarolim.
Nutrients, 2018 Aug 24; 10(9). PMID: 30134536    Free PMC article.
The Intestinal Virome and Immunity.
Jessica A Neil, Ken Cadwell.
J Immunol, 2018 Sep 06; 201(6). PMID: 30181300    Free PMC article.
Experimental Models for Studying Food Allergy.
Cynthia Kanagaratham, Benjamin F Sallis, Edda Fiebiger.
Cell Mol Gastroenterol Hepatol, 2018 Sep 06; 6(3). PMID: 30182049    Free PMC article.
Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders.
Elizabeth J Hait, Douglas R McDonald.
Clin Rev Allergy Immunol, 2018 Sep 13; 57(2). PMID: 30206783
TLR Activation and Allergic Disease: Early Life Microbiome and Treatment.
Kathryn R Michels, Nicholas W Lukacs, Wendy Fonseca.
Curr Allergy Asthma Rep, 2018 Sep 28; 18(11). PMID: 30259206
Adjuvanted Immunotherapy Approaches for Peanut Allergy.
Brandi T Johnson-Weaver, Herman F Staats, A Wesley Burks, Michael D Kulis.
Front Immunol, 2018 Oct 16; 9. PMID: 30319619    Free PMC article.
Gut Mucosal Antibody Responses and Implications for Food Allergy.
Ramona A Hoh, Scott D Boyd.
Front Immunol, 2018 Oct 16; 9. PMID: 30319658    Free PMC article.
Perinatal antibiotic exposure alters composition of murine gut microbiota and may influence later responses to peanut antigen.
Rozlyn C T Boutin, Zach Dwyer, +3 authors, Shawn Hayley.
Allergy Asthma Clin Immunol, 2018 Nov 10; 14. PMID: 30410548    Free PMC article.
Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria.
Elizabeth A Kennedy, Katherine Y King, Megan T Baldridge.
Front Physiol, 2018 Nov 16; 9. PMID: 30429801    Free PMC article.
Highly Cited. Review.
Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function.
Shiyang Li, John W Bostick, +5 authors, Liang Zhou.
Immunity, 2018 Nov 18; 49(5). PMID: 30446384    Free PMC article.
Highly Cited.
Solid Food Introduction and the Development of Food Allergies.
Carlo Caffarelli, Dora Di Mauro, +3 authors, Giampaolo Ricci.
Nutrients, 2018 Nov 21; 10(11). PMID: 30453619    Free PMC article.
Recent advances in understanding and preventing peanut and tree nut hypersensitivity.
Ayan Kusari, Allison Han, Lawrence Eichenfield.
F1000Res, 2018 Nov 24; 7. PMID: 30467518    Free PMC article.
Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants.
Bing Ma, Elias McComb, +6 authors, Rose M Viscardi.
Front Microbiol, 2018 Nov 30; 9. PMID: 30487786    Free PMC article.
In the ZOne: How Impedance Facilitates Progress in Functional Dyspepsia Research.
Simon Keely, Nicholas J Talley.
Dig Dis Sci, 2019 Mar 20; 64(11). PMID: 30887149
Gut microbiota from infant with cow's milk allergy promotes clinical and immune features of atopy in a murine model.
Aurélie Mauras, Harm Wopereis, +15 authors, Anne-Judith Waligora-Dupriet.
Allergy, 2019 Mar 20; 74(9). PMID: 30887528    Free PMC article.
Regulation of oral immune tolerance by the microbiome in food allergy.
Emmanuel Stephen-Victor, Talal A Chatila.
Curr Opin Immunol, 2019 Jul 16; 60. PMID: 31302570    Free PMC article.
Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile-Young Adult Rats.
Janyerkye Tulyeu, Hideki Kumagai, +6 authors, Takanori Yamagata.
Microorganisms, 2019 Oct 19; 7(10). PMID: 31623229    Free PMC article.
Herbal Formula-3 ameliorates OVA-induced food allergy in mice may via modulating the gut microbiota.
Sheng Liu, Bo Yang, Pingchang Yang, Zhigang Liu.
Am J Transl Res, 2019 Oct 22; 11(9). PMID: 31632550    Free PMC article.
Primary Prevention of Cow's Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow's Milk Formula at Birth: A Randomized Clinical Trial.
Mitsuyoshi Urashima, Hidetoshi Mezawa, +4 authors, Hiroshi Tachimoto.
JAMA Pediatr, 2019 Oct 22; 173(12). PMID: 31633778    Free PMC article.
Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome.
Ziying Zhang, Haosheng Tang, +2 authors, Yongguang Tao.
Signal Transduct Target Ther, 2019 Oct 23; 4. PMID: 31637019    Free PMC article.
A decreased abundance of clostridia characterizes the gut microbiota in eosinophilic esophagitis.
Purna C Kashyap, Stephen Johnson, +5 authors, David A Katzka.
Physiol Rep, 2019 Oct 28; 7(20). PMID: 31650712    Free PMC article.
Immune Activation in Functional Gastrointestinal Disorders.
Grace Burns, Jennifer Pryor, +3 authors, Simon Keely.
Gastroenterol Hepatol (N Y), 2019 Dec 06; 15(10). PMID: 31802978    Free PMC article.
Food allergy and the microbiome: Current understandings and future directions.
Supinda Bunyavanich, M Cecilia Berin.
J Allergy Clin Immunol, 2019 Dec 10; 144(6). PMID: 31812181    Free PMC article.
Microbial interactions in the atopic march.
B Nibbering, N D J Ubags.
Clin Exp Immunol, 2019 Nov 30; 199(1). PMID: 31777060    Free PMC article.
'Layered immunity' and the 'neonatal window of opportunity' - timed succession of non-redundant phases to establish mucosal host-microbial homeostasis after birth.
Mathias W Hornef, Natalia Torow.
Immunology, 2019 Nov 30; 159(1). PMID: 31777069    Free PMC article.
Oesophageal eosinophilia accompanies food allergy to hen egg white protein in young pigs.
Nathalie J Plundrich, Andrew R Smith, +7 authors, Scott M Laster.
Clin Exp Allergy, 2019 Nov 09; 50(1). PMID: 31702085    Free PMC article.
Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis.
Shohei Matsui, Hideo Kataoka, +10 authors, Hirotaka Kuwata.
Infect Immun, 2019 Oct 16; 88(1). PMID: 31611274    Free PMC article.
Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis.
Shashi P Singh, Hitendra S Chand, +4 authors, Mohan Sopori.
Dig Dis Sci, 2019 Oct 24; 65(1). PMID: 31643033    Free PMC article.
Recent developments in understanding the mechanisms of food allergy.
Zoe C Schmiechen, Katherine A Weissler, Pamela A Frischmeyer-Guerrerio.
Curr Opin Pediatr, 2019 Nov 07; 31(6). PMID: 31693591    Free PMC article.
Dietary Patterns Impact Temporal Dynamics of Fecal Microbiota Composition in Children With Autism Spectrum Disorder.
Kirsten Berding, Sharon M Donovan.
Front Nutr, 2020 Jan 31; 6. PMID: 31998741    Free PMC article.
Using Precisely Defined in vivo Microbiotas to Understand Microbial Regulation of IgE.
Madeleine Wyss, Kirsty Brown, +8 authors, Kathy D McCoy.
Front Immunol, 2020 Feb 06; 10. PMID: 32010146    Free PMC article.
Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis.
Karin Ried.
Exp Ther Med, 2020 Feb 06; 19(2). PMID: 32010325    Free PMC article.
The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review.
María Dolores Mesa, Begoña Loureiro, +26 authors, Fernando Cabañas.
Nutrients, 2020 Jan 08; 12(1). PMID: 31906588    Free PMC article.
Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity.
Rodrigo Jiménez-Saiz, Varun C Anipindi, +13 authors, Manel Jordana.
Front Immunol, 2020 Mar 03; 11. PMID: 32117293    Free PMC article.
Early-life gut microbiome and egg allergy.
M Fazlollahi, Y Chun, +8 authors, S Bunyavanich.
Allergy, 2018 Jan 11; 73(7). PMID: 29318631    Free PMC article.
A Summary of the Third Annual HIV Microbiome Workshop.
Brett Williams, Charles Boucher, +11 authors, Alan Landay.
AIDS Res Hum Retroviruses, 2018 Aug 15; 34(10). PMID: 30105916    Free PMC article.
The gut microbiome in food allergy.
William Zhao, Hsi-En Ho, Supinda Bunyavanich.
Ann Allergy Asthma Immunol, 2018 Dec 24; 122(3). PMID: 30578857    Free PMC article.
Healthy infants harbor intestinal bacteria that protect against food allergy.
Taylor Feehley, Catherine H Plunkett, +11 authors, Cathryn R Nagler.
Nat Med, 2019 Jan 16; 25(3). PMID: 30643289    Free PMC article.
Highly Cited.
Utilizing longitudinal microbiome taxonomic profiles to predict food allergy via Long Short-Term Memory networks.
Ahmed A Metwally, Philip S Yu, +3 authors, David L Perkins.
PLoS Comput Biol, 2019 Feb 05; 15(2). PMID: 30716085    Free PMC article.
Mechanisms that define transient versus persistent food allergy.
M Cecilia Berin.
J Allergy Clin Immunol, 2019 Feb 10; 143(2). PMID: 30736894    Free PMC article.
Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy.
Martin Schwarzer, Petra Hermanova, +9 authors, Irma Schabussova.
Front Immunol, 2019 Feb 28; 10. PMID: 30809227    Free PMC article.
Gut Microbiome as Target for Innovative Strategies Against Food Allergy.
Roberto Berni Canani, Lorella Paparo, +7 authors, Danilo Ercolini.
Front Immunol, 2019 Mar 05; 10. PMID: 30828329    Free PMC article.
Microbial Adjuncts for Food Allergen Immunotherapy.
Hsi-En Ho, Supinda Bunyavanich.
Curr Allergy Asthma Rep, 2019 Mar 25; 19(5). PMID: 30903301
In Vitro and In Vivo Activities of Zinc Linolenate, a Selective Antibacterial Agent against Helicobacter pylori.
Yanqiang Huang, Xudong Hang, +5 authors, Hongkai Bi.
Antimicrob Agents Chemother, 2019 Apr 03; 63(6). PMID: 30936098    Free PMC article.
Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity.
Lishan Li, Shitao Rao, +5 authors, Li Yang.
Microbiologyopen, 2019 Apr 20; 8(8). PMID: 31001921    Free PMC article.
Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota.
Sung-Wook Hong, Eunju O, +6 authors, Kwang Soon Kim.
Sci Adv, 2019 May 28; 5(5). PMID: 31131325    Free PMC article.
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy.
Azza Abdel-Gadir, Emmanuel Stephen-Victor, +15 authors, Talal A Chatila.
Nat Med, 2019 Jun 27; 25(7). PMID: 31235962    Free PMC article.
Highly Cited.
Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?
Laure Castan, Katrine L Bøgh, +14 authors, Shanna Bastiaan-Net.
Allergy, 2019 Jun 13; 75(2). PMID: 31187876    Free PMC article.
Calorie restriction and its impact on gut microbial composition and global metabolism.
Xiaojiao Zheng, Shouli Wang, Wei Jia.
Front Med, 2018 Nov 18; 12(6). PMID: 30446879
Influences on allergic mechanisms through gut, lung, and skin microbiome exposures.
Andrea M Kemter, Cathryn R Nagler.
J Clin Invest, 2019 Mar 05; 129(4). PMID: 30830878    Free PMC article.
Mechanisms of gastrointestinal allergic disorders.
Nurit P Azouz, Marc E Rothenberg.
J Clin Invest, 2019 Mar 12; 129(4). PMID: 30855279    Free PMC article.
Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings.
Suprabhat Mukherjee, Nikhilesh Joardar, Subhasree Sengupta, Santi P Sinha Babu.
J Nutr Biochem, 2018 Sep 10; 61. PMID: 30196243    Free PMC article.
The gut microbiota, environmental factors, and links to the development of food allergy.
Khui Hung Lee, Yong Song, +2 authors, Guicheng Zhang.
Clin Mol Allergy, 2020 Apr 09; 18. PMID: 32265597    Free PMC article.
In sickness and health: Effects of gut microbial metabolites on human physiology.
Robert W P Glowacki, Eric C Martens.
PLoS Pathog, 2020 Apr 10; 16(4). PMID: 32271839    Free PMC article.
Innate Lymphoid Cells in Mucosal Immunity.
Santosh K Panda, Marco Colonna.
Front Immunol, 2019 May 28; 10. PMID: 31134050    Free PMC article.
Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy.
Takashi Fujimura, Shelly Zing Chin Lum, +2 authors, Michiko K Oyoshi.
Front Immunol, 2019 Sep 12; 10. PMID: 31507589    Free PMC article.
Drugging the microbiome.
Cathryn R Nagler.
J Exp Med, 2020 Mar 10; 217(4). PMID: 32150223    Free PMC article.
Microbiome Composition and Its Impact on the Development of Allergic Diseases.
Diego G Peroni, Giulia Nuzzi, +2 authors, Pasquale Comberiati.
Front Immunol, 2020 May 12; 11. PMID: 32391012    Free PMC article.
Impact of antimicrobial therapy on the gut microbiome.
Amira A Bhalodi, Tjitske S R van Engelen, Harjeet S Virk, W Joost Wiersinga.
J Antimicrob Chemother, 2019 Jan 29; 74(Suppl 1). PMID: 30690540    Free PMC article.
Highly Cited. Review.
The Effects of Low-Nickel Diet Combined with Oral Administration of Selected Probiotics on Patients with Systemic Nickel Allergy Syndrome (SNAS) and Gut Dysbiosis.
Francesca Lombardi, Fabiana Fiasca, +6 authors, Mauro Minelli.
Nutrients, 2020 Apr 15; 12(4). PMID: 32283870    Free PMC article.
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes.
Hemraj B Dodiya, Thomas Kuntz, +8 authors, Sangram S Sisodia.
J Exp Med, 2019 May 18; 216(7). PMID: 31097468    Free PMC article.
Highly Cited.
Dietary AhR Ligands Regulate AhRR Expression in Intestinal Immune Cells and Intestinal Microbiota Composition.
Oliver Schanz, Rieka Chijiiwa, +4 authors, Irmgard Förster.
Int J Mol Sci, 2020 May 06; 21(9). PMID: 32366032    Free PMC article.
Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites.
Michael W Dougherty, Oleksandr Kudin, +3 authors, Christian Jobin.
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Advances in the Relationships Between Cow's Milk Protein Allergy and Gut Microbiota in Infants.
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Partially Hydrolysed Whey Has Superior Allergy Preventive Capacity Compared to Intact Whey Regardless of Amoxicillin Administration in Brown Norway Rats.
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Antibiotic-Induced Gut Microbiota Dysbiosis Damages the Intestinal Barrier, Increasing Food Allergy in Adult Mice.
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Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome.
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Microbiome of Barrier Organs in Allergy: Who Runs the World? Germs!
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Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations.
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