Journal Article
. 2014 Nov; 22(8):633-50.
doi: 10.1089/ars.2014.5887.

Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy

Tianbao Yao 1 Xiaoying Ying  Yichao Zhao  Ancai Yuan  Qing He  Huan Tong  Song Ding  Junling Liu  Xu Peng  Erhe Gao  Jun Pu  Ben He  
  • PMID: 25365634
  •     60 References
  •     53 citations


Aims: To determine the roles of vitamin D receptor (VDR) in ischemia/reperfusion-induced myocardial injury and to investigate the underlying mechanisms involved.

Results: The endogenous VDR expression was detected in the mouse heart, and myocardial ischemia/reperfusion (MI/R) upregulated VDR expression. Activation of VDR by natural and synthetic agonists reduced myocardial infarct size and improved cardiac function. Mechanistically, VDR activation inhibited endoplasmic reticulum (ER) stress (determined by the reduction of CCAAT/enhancer-binding protein homologous protein expression and caspase-12 activation), attenuated mitochondrial impairment (determined by the decrease of mitochondrial cytochrome c release and caspase-9 activation), and reduced cardiomyocyte apoptosis. Furthermore, VDR activation significantly inhibited MI/R-induced autophagy dysfunction (determined by the inhibition of Beclin 1 over-activation, the reduction of autophagosomes, the LC3-II/LC3-I ratio, p62 protein abundance, and the restoration of autophagy flux). Moreover, VDR activation inhibited MI/R-induced oxidative stress through a metallothionein-dependent mechanism. The cardioprotective effects of VDR agonists mentioned earlier were impaired in the setting of cardiac-specific VDR silencing. In contrast, adenovirus-mediated cardiac VDR overexpression decreased myocardial infarct size and improved cardiac function through attenuating oxidative stress, and inhibiting apoptosis and autophagy dysfunction.

Innovation And Conclusion: Our data demonstrate that VDR is a novel endogenous self-defensive and cardioprotective receptor against MI/R injury, via mechanisms (at least in part) reducing oxidative stress, and inhibiting apoptosis and autophagy dysfunction-mediated cell death.

Vitamin D signaling pathway plays an important role in the development of heart failure after myocardial infarction.
Soochan Bae, Sylvia S Singh, +3 authors, Peter M Kang.
J Appl Physiol (1985), 2013 Feb 23; 114(8). PMID: 23429874    Free PMC article.
Paricalcitol attenuates cyclosporine-induced kidney injury in rats.
Jeong Woo Park, Eun Hui Bae, +4 authors, Soo Wan Kim.
Kidney Int, 2010 Mar 20; 77(12). PMID: 20237458
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.
Yutaka Matsui, Hiromitsu Takagi, +5 authors, Junichi Sadoshima.
Circ Res, 2007 Mar 03; 100(6). PMID: 17332429
Highly Cited.
Insights into echo-attenuated plaques, echolucent plaques, and plaques with spotty calcification: novel findings from comparisons among intravascular ultrasound, near-infrared spectroscopy, and pathological histology in 2,294 human coronary artery segments.
Jun Pu, Gary S Mintz, +11 authors, Akiko Maehara.
J Am Coll Cardiol, 2014 Apr 01; 63(21). PMID: 24681142
Vitamin D and human health: lessons from vitamin D receptor null mice.
Roger Bouillon, Geert Carmeliet, +6 authors, Marie Demay.
Endocr Rev, 2008 Aug 13; 29(6). PMID: 18694980    Free PMC article.
Highly Cited. Review.
The role of autophagy in the heart.
K Nishida, S Kyoi, +2 authors, K Otsu.
Cell Death Differ, 2008 Nov 15; 16(1). PMID: 19008922
Highly Cited. Review.
Vitamin D and disease prevention with special reference to cardiovascular disease.
Armin Zittermann.
Prog Biophys Mol Biol, 2006 Apr 08; 92(1). PMID: 16600341
Highly Cited. Review.
Construction of a bicistronic recombinant adenoviral vector for human interleukin-10 and enhanced green fluorescent protein expression in bone marrow mesenchymal stem cells.
Jian-Qing Lin, Cai-Zhu Lin, +2 authors, You-Guang Gao.
Chin Med J (Engl), 2012 Feb 22; 125(1). PMID: 22340474
Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion.
Katharina Schmidt, Renaud Tissier, +3 authors, Thomas Krieg.
Eur Heart J, 2009 Dec 24; 31(13). PMID: 20028693    Free PMC article.
Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?
Constantinos Pantos, Iordanis Mourouzis, +9 authors, Dennis V Cokkinos.
Basic Res Cardiol, 2008 Dec 23; 104(1). PMID: 19101750
Autophagy as a therapeutic target for ischaemia /reperfusion injury? Concepts, controversies, and challenges.
Karin Przyklenk, Yi Dong, Vishnu V Undyala, Peter Whittaker.
Cardiovasc Res, 2012 Jan 05; 94(2). PMID: 22215722
Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury.
Xiucui Ma, Haiyan Liu, +4 authors, Abhinav Diwan.
Circulation, 2012 May 18; 125(25). PMID: 22592897    Free PMC article.
Highly Cited.
Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury.
Keiichi Hishikari, Jun-ichi Suzuki, +5 authors, Mitsuaki Isobe.
Cardiovasc Res, 2008 Sep 23; 81(1). PMID: 18805784    Free PMC article.
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.
Atsuko Nakai, Osamu Yamaguchi, +11 authors, Kinya Otsu.
Nat Med, 2007 Apr 24; 13(5). PMID: 17450150
Highly Cited.
Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2.
Yoshinori Katsumata, Ken Shinmura, +11 authors, Motoaki Sano.
Hypertension, 2013 Oct 09; 63(1). PMID: 24101662
Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells.
Bo-Ying Bao, Huei-Ju Ting, Jong-Wei Hsu, Yi-Fen Lee.
Int J Cancer, 2008 Mar 19; 122(12). PMID: 18348143
Autophagy, redox signaling, and ventricular remodeling.
Narasimman Gurusamy, Dipak K Das.
Antioxid Redox Signal, 2009 Mar 31; 11(8). PMID: 19327038    Free PMC article.
Activation of Liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury.
Peng Lei, Anton Baysa, +5 authors, Fred Haugen.
Basic Res Cardiol, 2012 Dec 26; 108(1). PMID: 23266787
Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway.
Qian Fan, Mai Chen, +9 authors, Erhe Gao.
PLoS One, 2013 Jun 28; 8(6). PMID: 23805205    Free PMC article.
Imaging of vulnerable atherosclerotic plaques with FDG-microPET: no FDG accumulation.
Jacob Marsvin Laurberg, Aage Kristian Olsen, +4 authors, Erling Falk.
Atherosclerosis, 2006 Aug 22; 192(2). PMID: 16919635
Testosterone protects rat hearts against ischaemic insults by enhancing the effects of alpha(1)-adrenoceptor stimulation.
S Tsang, S Wu, J Liu, T M Wong.
Br J Pharmacol, 2007 Dec 25; 153(4). PMID: 18157169    Free PMC article.
Oxidative stress stimulates autophagic flux during ischemia/reperfusion.
Nirmala Hariharan, Peiyong Zhai, Junichi Sadoshima.
Antioxid Redox Signal, 2010 Sep 04; 14(11). PMID: 20812860    Free PMC article.
Highly Cited.
Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat.
Amar Kapoor, Massimo Collino, +2 authors, Christoph Thiemermann.
Shock, 2009 Dec 10; 34(2). PMID: 19997057
Expression of skeletal muscle sodium channel (Nav1.4) or connexin32 prevents reperfusion arrhythmias in murine heart.
Evgeny P Anyukhovsky, Eugene A Sosunov, +6 authors, Michael R Rosen.
Cardiovasc Res, 2010 Sep 09; 89(1). PMID: 20823275    Free PMC article.
Autophagy signaling through reactive oxygen species.
Ju Huang, Grace Y Lam, John H Brumell.
Antioxid Redox Signal, 2010 Sep 30; 14(11). PMID: 20874258
Low-dose spironolactone prevents apoptosis repressor with caspase recruitment domain degradation during myocardial infarction.
Thi Yen Loan Le, Mahidi Mardini, +3 authors, Anastasia S Mihailidou.
Hypertension, 2012 Apr 18; 59(6). PMID: 22508833
Autophagy in ischemic heart disease.
Asa B Gustafsson, Roberta A Gottlieb.
Circ Res, 2009 Jan 31; 104(2). PMID: 19179668    Free PMC article.
Highly Cited. Review.
Vitamin D and prognosis in acute myocardial infarction.
Leong L Ng, Jatinderpal Kaur Sandhu, +2 authors, Donald J L Jones.
Int J Cardiol, 2013 Feb 19; 168(3). PMID: 23415169
Differential inhibition of renin mRNA expression by paricalcitol and calcitriol in C57/BL6 mice.
Ryan M Fryer, Pamela A Rakestraw, +5 authors, Glenn A Reinhart.
Nephron Physiol, 2007 Jul 12; 106(4). PMID: 17622742
VDR primary targets by genome-wide transcriptional profiling.
Frauke Goeman, Francesca De Nicola, +8 authors, Paola Muti.
J Steroid Biochem Mol Biol, 2014 Apr 15; 143. PMID: 24726990
Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity.
Songcang Chen, Christopher S Law, David G Gardner.
J Steroid Biochem Mol Biol, 2009 Dec 08; 118(3). PMID: 19961935    Free PMC article.
Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years.
Jan R Ortlepp, Constanze Krantz, +9 authors, Rainer Hoffmann.
Int J Cardiol, 2005 Oct 07; 105(1). PMID: 16207551
Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart.
Heng Ma, Jingying Wang, +9 authors, Ji Li.
Circulation, 2010 Jul 08; 122(3). PMID: 20606117    Free PMC article.
A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse.
Erhe Gao, Yong Hong Lei, +7 authors, Walter J Koch.
Circ Res, 2010 Oct 23; 107(12). PMID: 20966393    Free PMC article.
Highly Cited.
Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals.
Natalya Bodyak, Juan Carlos Ayus, +11 authors, Peter M Kang.
Proc Natl Acad Sci U S A, 2007 Oct 19; 104(43). PMID: 17942703    Free PMC article.
Oxidative stress and autophagy in cardiovascular homeostasis.
Cyndi R Morales, Zully Pedrozo, Sergio Lavandero, Joseph A Hill.
Antioxid Redox Signal, 2013 May 07; 20(3). PMID: 23641894    Free PMC article.
Vitamin D protects human endothelial cells from H₂O₂ oxidant injury through the Mek/Erk-Sirt1 axis activation.
Lorella Polidoro, G Properzi, +7 authors, C Ferri.
J Cardiovasc Transl Res, 2012 Dec 19; 6(2). PMID: 23247634
Simplified apoptotic cascades.
Mehregan Movassagh, Roger S-Y Foo.
Heart Fail Rev, 2007 Dec 18; 13(2). PMID: 18080749
Ethanol and vitamin D receptor in T cell apoptosis.
Shabina Rehman, Nirupama Chandel, +6 authors, Pravin C Singhal.
J Neuroimmune Pharmacol, 2012 Oct 12; 8(1). PMID: 23054367    Free PMC article.
Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress.
Jinghui Dong, Siu Ling Wong, +7 authors, Yu Huang.
Eur Heart J, 2012 Jan 24; 33(23). PMID: 22267242
Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury.
Qing He, Jun Pu, +5 authors, Ben He.
Circ Heart Fail, 2014 Oct 04; 7(6). PMID: 25277999    Free PMC article.
Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis.
Zhaokang Cheng, Mirko Völkers, +13 authors, Mark A Sussman.
Eur Heart J, 2011 Jan 14; 32(17). PMID: 21228009    Free PMC article.
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.
Tomonori Kawaguchi, Genzou Takemura, +12 authors, Shinya Minatoguchi.
Cardiovasc Res, 2012 Sep 07; 96(3). PMID: 22952253
Cardioprotection mediated by rosiglitazone, a peroxisome proliferator-activated receptor gamma ligand, in relation to nitric oxide.
Adrian T Gonon, Aliaksandr Bulhak, +2 authors, John Pernow.
Basic Res Cardiol, 2006 Aug 11; 102(1). PMID: 16900441
Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy.
Songcang Chen, Christopher S Law, +5 authors, David G Gardner.
Circulation, 2011 Sep 29; 124(17). PMID: 21947295    Free PMC article.
Highly Cited.
Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection.
Yajing Wang, Xiaoliang Wang, +9 authors, Xin-Liang Ma.
Arterioscler Thromb Vasc Biol, 2012 Feb 14; 32(4). PMID: 22328772    Free PMC article.
Vitamin D deficiency and risk of cardiovascular disease.
Thomas J Wang, Michael J Pencina, +7 authors, Ramachandran S Vasan.
Circulation, 2008 Jan 09; 117(4). PMID: 18180395    Free PMC article.
Highly Cited.
Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1.
A A Bulhak, P-O Sjöquist, +2 authors, J Pernow.
Basic Res Cardiol, 2006 Jan 18; 101(3). PMID: 16411023
Autophagy is impaired in cardiac ischemia-reperfusion injury.
Xiucui Ma, Haiyan Liu, +3 authors, Abhinav Diwan.
Autophagy, 2012 Aug 15; 8(9). PMID: 22889942    Free PMC article.
On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment.
Radoslaw Michalski, Bartosz Michalowski, +2 authors, Balaraman Kalyanaraman.
Free Radic Biol Med, 2013 Nov 10; 67. PMID: 24200598    Free PMC article.
Mitochondrial pathways, permeability transition pore, and redox signaling in cardioprotection: therapeutic implications.
Claudia Penna, Maria-Giulia Perrelli, Pasquale Pagliaro.
Antioxid Redox Signal, 2012 Jun 07; 18(5). PMID: 22668069
Estrogen receptor-beta activation results in S-nitrosylation of proteins involved in cardioprotection.
Jeffrey Lin, Charles Steenbergen, Elizabeth Murphy, Junhui Sun.
Circulation, 2009 Jul 08; 120(3). PMID: 19581491    Free PMC article.
Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde.
Heng Ma, Rui Guo, +2 authors, Jun Ren.
Eur Heart J, 2010 Aug 14; 32(8). PMID: 20705694    Free PMC article.
Highly Cited.
Cardiac fibroblasts protect cardiomyocytes against lethal ischemia-reperfusion injury.
Maryline Abrial, Claire Crola Da Silva, +7 authors, René Ferrera.
J Mol Cell Cardiol, 2014 Jan 21; 68. PMID: 24440456
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury.
Jun Pu, Ancai Yuan, +7 authors, Ben He.
Eur Heart J, 2012 Feb 07; 34(24). PMID: 22307460    Free PMC article.
Expression of the vitamin d receptor is increased in the hypertrophic heart.
Songcang Chen, Denis J Glenn, +5 authors, David G Gardner.
Hypertension, 2008 Oct 22; 52(6). PMID: 18936343    Free PMC article.
Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice.
Shinsuke Suemori, Masamitsu Shimazawa, +4 authors, Hideaki Hara.
Invest Ophthalmol Vis Sci, 2006 Aug 29; 47(9). PMID: 16936113
Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats.
Soochan Bae, Bhargavi Yalamarti, +6 authors, Peter M Kang.
Cardiovasc Res, 2011 May 14; 91(4). PMID: 21565836    Free PMC article.
Protective effect of melatonin and 1,25-dihydroxyvitamin D3 on renal ischemia-reperfusion injury in rats.
Gülbüz Sezgin, Güler Oztürk, +2 authors, Matem Tunçdemir.
Ren Fail, 2013 Jan 30; 35(3). PMID: 23356461
1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus.
Jisu Oh, Sherry Weng, +9 authors, Carlos Bernal-Mizrachi.
Circulation, 2009 Aug 12; 120(8). PMID: 19667238    Free PMC article.
Highly Cited.
Can L-Cysteine and Vitamin D Rescue Vitamin D and Vitamin D Binding Protein Levels in Blood Plasma of African American Type 2 Diabetic Patients?
Sushil K Jain, Gunjan Kahlon, +2 authors, Cassandra Warden.
Antioxid Redox Signal, 2015 Mar 31; 23(8). PMID: 25816831    Free PMC article.
Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury.
Yuhuang Lang, Fengming Fu, +2 authors, Fengyuan Chen.
PLoS One, 2015 Jul 18; 10(7). PMID: 26186619    Free PMC article.
Multiscale Characterization of Impact of Infarct Size on Myocardial Remodeling in an Ovine Infarct Model.
Pei Zhang, Tielou Li, Bartley P Griffith, Zhongjun J Wu.
Cells Tissues Organs, 2014 Jan 01; 200(5). PMID: 26540290    Free PMC article.
Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome.
Ling Gao, Jia-Tian Cao, +9 authors, He-Feng Huang.
Endocrine, 2015 Nov 19; 52(2). PMID: 26578366
Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress.
Yun-peng Li, Shu-lin Wang, +10 authors, Ai-hua Chen.
Acta Pharmacol Sin, 2016 Jan 19; 37(3). PMID: 26775664    Free PMC article.
Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases.
Mei-qing Liu, Zhe Chen, Lin-xi Chen.
Acta Pharmacol Sin, 2016 Feb 04; 37(4). PMID: 26838072    Free PMC article.
Alk7 Depleted Mice Exhibit Prolonged Cardiac Repolarization and Are Predisposed to Ventricular Arrhythmia.
Shaozhen Ying, Hong Cao, +3 authors, Congxin Huang.
PLoS One, 2016 Feb 18; 11(2). PMID: 26882027    Free PMC article.
The role of 1,25-dyhydroxyvitamin D3 in mouse liver ischemia reperfusion injury: regulation of autophagy through activation of MEK/ERK signaling and PTEN/PI3K/Akt/mTORC1 signaling.
Jinghui Yang, Qi Chen, +4 authors, Zhiren Fu.
Am J Transl Res, 2016 Feb 18; 7(12). PMID: 26885262    Free PMC article.
Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases.
Meng Li, Ping Gao, Junping Zhang.
Int J Mol Sci, 2016 Mar 08; 17(3). PMID: 26950124    Free PMC article.
YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α.
Yichao Zhao, Longwei Xu, +7 authors, Jun Pu.
Sci Rep, 2016 Mar 12; 6. PMID: 26964694    Free PMC article.
Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases.
Mei Shang, Jun Sun.
Curr Med Chem, 2016 Dec 06; 24(9). PMID: 27915988    Free PMC article.
Plant-based foods containing cell wall polysaccharides rich in specific active monosaccharides protect against myocardial injury in rat myocardial infarction models.
Sun Ha Lim, Yaesil Kim, +4 authors, Jongwon Lee.
Sci Rep, 2016 Dec 09; 6. PMID: 27929093    Free PMC article.
Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy.
Yanjun Zheng, Shanshan Gu, +6 authors, Huang-Tian Yang.
Cell Death Dis, 2017 Feb 06; 8(2). PMID: 28151484    Free PMC article.
Vitamin D and acute myocardial infarction.
Valentina Milazzo, Monica De Metrio, +2 authors, Elena Tremoli.
World J Cardiol, 2017 Feb 07; 9(1). PMID: 28163832    Free PMC article.
Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4.
Li Yao, Yongyan Shi, +4 authors, Xindong Xue.
Int J Mol Med, 2017 Apr 26; 39(6). PMID: 28440468    Free PMC article.
Endoplasmic reticulum stress in the heart: insights into mechanisms and drug targets.
Shunyao Wang, Pablo Binder, +4 authors, Xin Wang.
Br J Pharmacol, 2017 May 27; 175(8). PMID: 28548229    Free PMC article.
Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy.
Xiaoyun Zeng, Xintian Yu, +2 authors, Jun Zhu.
Lipids Health Dis, 2017 Jun 10; 16(1). PMID: 28595623    Free PMC article.
Chen Yunzhi, Chen Jiaxu, +3 authors, Qin Zhong.
Afr J Tradit Complement Altern Med, 2017 Jun 24; 14(4). PMID: 28638891    Free PMC article.
Verapamil suppresses cardiac alternans and ventricular arrhythmias in acute myocardial ischemia via ryanodine receptor inhibition.
Yu-Lei Deng, Jun-Yan Zhao, +6 authors, Xiao-Qing Quan.
Am J Transl Res, 2017 Jul 04; 9(6). PMID: 28670363    Free PMC article.
Role of Vitamin D in Cardiovascular Diseases.
Vikrant Rai, Devendra K Agrawal.
Endocrinol Metab Clin North Am, 2017 Oct 31; 46(4). PMID: 29080634    Free PMC article.
High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway.
Ouyang Chen, Zhiyong Cao, +9 authors, Xuejun Sun.
Sci Rep, 2017 Nov 03; 7(1). PMID: 29093541    Free PMC article.
Hyperbaric oxygen protects against myocardial reperfusion injury via the inhibition of inflammation and the modulation of autophagy.
Chunxia Chen, Wan Chen, +7 authors, Guangwei Wu.
Oncotarget, 2018 Jan 18; 8(67). PMID: 29340072    Free PMC article.
Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke.
Megan A Evans, Hyun Ah Kim, +9 authors, Christopher G Sobey.
Neuromolecular Med, 2018 Feb 25; 20(1). PMID: 29476479    Free PMC article.
A Simple and Efficient Method for In Vivo Cardiac-specific Gene Manipulation by Intramyocardial Injection in Mice.
Yanan Fu, Wenlong Jiang, +4 authors, Jun Pu.
J Vis Exp, 2018 May 01; (134). PMID: 29708533    Free PMC article.
Effects of Vitamin D3 on the NADPH Oxidase and Matrix Metalloproteinase 9 in an Animal Model of Global Cerebral Ischemia.
Milica Velimirović, Gordana Jevtić Dožudić, +10 authors, Nataša D Petronijević.
Oxid Med Cell Longev, 2018 Jun 01; 2018. PMID: 29849881    Free PMC article.
Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy.
Shiyong Wu, Guanglei Chang, +7 authors, Dongying Zhang.
J Mol Med (Berl), 2018 Jun 30; 96(8). PMID: 29955901
BMS‑345541 inhibits airway inflammation and epithelial‑mesenchymal transition in airway remodeling of asthmatic mice.
Xiaohua Zhu, Qiugen Li, +5 authors, Ying Zhong.
Int J Mol Med, 2018 Jul 18; 42(4). PMID: 30015827    Free PMC article.
Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy.
Si-Yang Yu, Bo Dong, +3 authors, Sheng-Hua Zhou.
J Cell Mol Med, 2018 Jul 27; 22(10). PMID: 30047214    Free PMC article.
Identification of protein complexes associated with myocardial infarction using a bioinformatics approach.
Nianhui Jiao, Yongjie Qi, +2 authors, Fengyong Yang.
Mol Med Rep, 2018 Aug 23; 18(4). PMID: 30132549    Free PMC article.
Pretreatment with Total Flavonoid Extract from Dracocephalum Moldavica L. Attenuates Ischemia Reperfusion-induced Apoptosis.
Cheng Zeng, Wen Jiang, +3 authors, Jianguo Xing.
Sci Rep, 2018 Dec 07; 8(1). PMID: 30504832    Free PMC article.
Imbalance of autophagy and apoptosis in intestinal epithelium lacking the vitamin D receptor.
Rong Lu, Yong-Guo Zhang, Yinglin Xia, Jun Sun.
FASEB J, 2019 Jul 31; 33(11). PMID: 31361973    Free PMC article.
CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells.
M D Khurshidul Zahid, Michael Rogowski, +3 authors, Shaikh M Rahman.
Mol Cell Biochem, 2019 Nov 07; 463(1-2). PMID: 31686316
α-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux.
Guohua Li, Xinpei Wang, +8 authors, Jia Li.
Cell Death Dis, 2020 Feb 06; 11(2). PMID: 32015327    Free PMC article.
Vitamin D Receptor gene polymorphisms and plasma levels are associated with lumbar disc degeneration.
Qinghua Yang, Yang Liu, +4 authors, Qingjun Wei.
Sci Rep, 2019 May 28; 9(1). PMID: 31127184    Free PMC article.
miRNA-mRNA crosstalk in myocardial ischemia induced by calcified aortic valve stenosis.
Chenyang Duan, Zhezhe Cao, +6 authors, Ruiyan Ma.
Aging (Albany NY), 2019 Jan 18; 11(2). PMID: 30651404    Free PMC article.
Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.
Yanchao Han, Anzhi Chen, +11 authors, Kenneth D Poss.
Dev Cell, 2019 Feb 05; 48(6). PMID: 30713073    Free PMC article.
Highly Cited.
Circular RNAs in gynecological disease: promising biomarkers and diagnostic targets.
Jie Huang, Qin Zhou, Yunyun Li.
Biosci Rep, 2019 Apr 19; 39(5). PMID: 30996117    Free PMC article.
p62 functions as an oncogene in colorectal cancer through inhibiting apoptosis and promoting cell proliferation by interacting with the vitamin D receptor.
Jing Zhang, Suzhen Yang, +10 authors, Lei Dong.
Cell Prolif, 2019 Feb 23; 52(3). PMID: 30793399    Free PMC article.
Downregulation of P300/CBP-Associated Factor Attenuates Myocardial Ischemia-Reperfusion Injury Via Inhibiting Autophagy.
Liqiang Qiu, Changwu Xu, +3 authors, Hong Jiang.
Int J Med Sci, 2020 Jun 18; 17(9). PMID: 32547315    Free PMC article.
Salvianolic Acid B Improves Postresuscitation Myocardial and Cerebral Outcomes in a Murine Model of Cardiac Arrest: Involvement of Nrf2 Signaling Pathway.
Qing-Qi Ji, Yan-Jie Li, +6 authors, Ben He.
Oxid Med Cell Longev, 2020 Jul 28; 2020. PMID: 32714485    Free PMC article.
Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γ Functional Module of Autophagy in Rheumatoid Arthritis.
Weiyan Wang, Chunling Li, Zhiyi Zhang, Yue Zhang.
PPAR Res, 2019 Jun 18; 2019. PMID: 31205465    Free PMC article.
Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D.
Natalia de Las Heras, Virna Margarita Martín Giménez, +2 authors, Vicente Lahera.
Antioxidants (Basel), 2020 Sep 25; 9(9). PMID: 32967329    Free PMC article.
Biogenesis and functions of circular RNAs and their role in diseases of the female reproductive system.
Yalan Ma, Ying Xu, Jingshun Zhang, Lianwen Zheng.
Reprod Biol Endocrinol, 2020 Nov 06; 18(1). PMID: 33148278    Free PMC article.
Supplemental 25-hydroxycholecalciferol Alleviates Inflammation and Cardiac Fibrosis in Hens.
Pao-Chia Chou, Yu-Hui Chen, +3 authors, Shuen-Ei Chen.
Int J Mol Sci, 2020 Nov 12; 21(21). PMID: 33171670    Free PMC article.
COX6B1 relieves hypoxia/reoxygenation injury of neonatal rat cardiomyocytes by regulating mitochondrial function.
Wei Zhang, Yu Wang, +2 authors, Fei Pei.
Biotechnol Lett, 2018 Oct 13; 41(1). PMID: 30311029    Free PMC article.
Pretreatment with Cholecalciferol Alleviates Renal Cellular Stress Response during Ischemia/Reperfusion-Induced Acute Kidney Injury.
Jun Li, Shen Xu, +9 authors, De-Xiang Xu.
Oxid Med Cell Longev, 2019 Apr 26; 2019. PMID: 31019650    Free PMC article.
Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation‑induced injury of H9c2 cardiomyocytes.
Gaopeng Guan, Lei Yang, +5 authors, Xiang Gu.
Mol Med Rep, 2019 May 23; 20(1). PMID: 31115545    Free PMC article.
Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy.
Tzu-Lin Lee, Ming-Hsueh Lee, +7 authors, Yuh-Lien Chen.
Front Pharmacol, 2020 Dec 29; 11. PMID: 33362559    Free PMC article.
Pretreatment of Huoxue Jiedu Formula Ameliorates Myocardial Ischaemia/Reperfusion Injury by Decreasing Autophagy via Activation of the PI3K/AKT/mTOR Pathway.
Linzi Long, Zikai Yu, +5 authors, Changgeng Fu.
Front Pharmacol, 2021 Mar 16; 12. PMID: 33716739    Free PMC article.
Hypertrophic preconditioning cardioprotection after myocardial ischaemia/reperfusion injury involves ALDH2-dependent metabolism modulation.
Lei-Lei Ma, Zhi-Wen Ding, +5 authors, Jun-Bo Ge.
Redox Biol, 2021 Apr 29; 43. PMID: 33910156    Free PMC article.
Hypertrophic Preconditioning Attenuates Myocardial Ischaemia-Reperfusion Injury by Modulating SIRT3-SOD2-mROS-Dependent Autophagy.
Lei-Lei Ma, Fei-Juan Kong, +5 authors, Jun-Bo Ge.
Cell Prolif, 2021 May 12; 54(7). PMID: 33973685    Free PMC article.
Unfolded protein response during cardiovascular disorders: a tilt towards pro-survival and cellular homeostasis.
Shreya Das, Arunima Mondal, +2 authors, Arunima Sengupta.
Mol Cell Biochem, 2021 Jul 15; 476(11). PMID: 34259975
Vitamin D3/VDR inhibits inflammation through NF-κB pathway accompanied by resisting apoptosis and inducing autophagy in abalone Haliotis discus hannai.
Dong Huang, Yanlin Guo, +4 authors, Kangsen Mai.
Cell Biol Toxicol, 2021 Oct 13;. PMID: 34637036