Genetic basis for clinical response to CTLA-4 blockade in melanoma

Alexandra Snyder ¹, Vladimir Makarov ¹, Taha Merghoub ¹, Jianda Yuan ¹, Jesse M Zaretsky ¹, Alexis Desrichard ¹, Logan A Walsh ¹, Michael A Postow ¹, Phillip Wong ¹, Teresa S Ho ¹, Travis J Hollmann ¹, Cameron Bruggeman ¹, Kasthuri Kannan ¹, Yanyun Li ¹, Ceyhan Elipenahli ¹, Cailian Liu ¹, Christopher T Harbison ¹, Lisu Wang ¹, Antoni Ribas ¹, Jedd D Wolchok ¹, Timothy A Chan ¹

Affiliations

¹ Department of Medicine (A.S., T.M., M.A.P., J.D.W.), Human Oncology and Pathogenesis Program (A.S., V.M., A.D., L.A.W., K.K., T.A.C.), Swim across America-Ludwig Collaborative Research Laboratory (T.M., Y.L., C.E., C.L., J.D.W.), Department of Radiation Oncology (T.A.C.), Department of Pathology (T.J.H.), and Immunology Program, Ludwig Center for Cancer Immunotherapy (J.Y., P.W., T.S.H., J.D.W.), Memorial Sloan Kettering Cancer Center; Weill Cornell Medical College (A.S., M.A.P., J.D.W., T.A.C.); and Department of Mathematics, Columbia University (C.B.) - all in New York; the Department of Molecular and Medical Pharmacology (J.M.Z., A.R.) and the Department of Medicine, Division of Hematology-Oncology, Jonsson Comprehensive Cancer Center (A.R.), University of California, Los Angeles, Los Angeles; and Bristol-Myers Squibb, Princeton, NJ (C.T.H., L.W.).

PMID: 25409260
36 References
1813 citations

Abstract

Background: Immune checkpoint inhibitors are effective cancer treatments, but molecular determinants of clinical benefit are unknown. Ipilimumab and tremelimumab are antibodies against cytotoxic T-lymphocyte antigen 4 (CTLA-4). Anti-CTLA-4 treatment prolongs overall survival in patients with melanoma. CTLA-4 blockade activates T cells and enables them to destroy tumor cells.

Methods: We obtained tumor tissue from patients with melanoma who were treated with ipilimumab or tremelimumab. Whole-exome sequencing was performed on tumors and matched blood samples. Somatic mutations and candidate neoantigens generated from these mutations were characterized. Neoantigen peptides were tested for the ability to activate lymphocytes from ipilimumab-treated patients.

Results: Malignant melanoma exomes from 64 patients treated with CTLA-4 blockade were characterized with the use of massively parallel sequencing. A discovery set consisted of 11 patients who derived a long-term clinical benefit and 14 patients who derived a minimal benefit or no benefit. Mutational load was associated with the degree of clinical benefit (P=0.01) but alone was not sufficient to predict benefit. Using genomewide somatic neoepitope analysis and patient-specific HLA typing, we identified candidate tumor neoantigens for each patient. We elucidated a neoantigen landscape that is specifically present in tumors with a strong response to CTLA-4 blockade. We validated this signature in a second set of 39 patients with melanoma who were treated with anti-CTLA-4 antibodies. Predicted neoantigens activated T cells from the patients treated with ipilimumab.

Conclusions: These findings define a genetic basis for benefit from CTLA-4 blockade in melanoma and provide a rationale for examining exomes of patients for whom anti-CTLA-4 agents are being considered. (Funded by the Frederick Adler Fund and others.).

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Evolving synergistic combinations of targeted immunotherapies to combat cancer. Ignacio Melero, David M Berman, +3 authors, John Haanen. less Nat Rev Cancer, 2015 Jul 25; 15(8). PMID: 26205340 Highly Cited. Review.
Therapeutic cancer vaccines. Cornelis J M Melief, Thorbald van Hall, +2 authors, Ramon Arens, Ferry Ossendorp, Sjoerd H van der Burg. less J Clin Invest, 2015 Jul 28; 125(9). PMID: 26214521 Free PMC article. Highly Cited. Review.
Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment. J David Peske, Amber B Woods, Victor H Engelhard. Adv Cancer Res, 2015 Jul 29; 128. PMID: 26216636 Free PMC article. Review.
Combined Trabectedin and anti-PD1 antibody produces a synergistic antitumor effect in a murine model of ovarian cancer. Zhiqiang Guo, Haolin Wang, +2 authors, Fandong Meng, Jie Li, Shulan Zhang. less J Transl Med, 2015 Jul 30; 13. PMID: 26219551 Free PMC article.
Origins, genetic landscape, and emerging therapies of small cell lung cancer. Ekaterina A Semenova, Remco Nagel, Anton Berns. Genes Dev, 2015 Jul 30; 29(14). PMID: 26220992 Free PMC article. Highly Cited. Review.
Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine. Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong. Yonsei Med J, 2015 Aug 11; 56(5). PMID: 26256958 Free PMC article. Review.
Tumor neoantigens: building a framework for personalized cancer immunotherapy. Matthew M Gubin, Maxim N Artyomov, Elaine R Mardis, Robert D Schreiber. J Clin Invest, 2015 Aug 11; 125(9). PMID: 26258412 Free PMC article. Highly Cited. Review.
Genomic spectra of biliary tract cancer. Hiromi Nakamura, Yasuhito Arai, +14 authors, Tatsuhiro Shibata. less Nat Genet, 2015 Aug 11; 47(9). PMID: 26258846 Highly Cited.
An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers. Kin Chan, Steven A Roberts, +9 authors, Dmitry A Gordenin. less Nat Genet, 2015 Aug 11; 47(9). PMID: 26258849 Free PMC article. Highly Cited.
Prospects of immune checkpoint modulators in the treatment of glioblastoma. Matthias Preusser, Michael Lim, +2 authors, David A Hafler, David A Reardon, John H Sampson. less Nat Rev Neurol, 2015 Aug 12; 11(9). PMID: 26260659 Free PMC article. Highly Cited. Review.
Gender Disparity and Mutation Burden in Metastatic Melanoma. Sameer Gupta, Mykyta Artomov, +2 authors, William Goggins, Mark Daly, Hensin Tsao. less J Natl Cancer Inst, 2015 Aug 25; 107(11). PMID: 26296643 Free PMC article.
Immunotherapy of Childhood Sarcomas. Stephen S Roberts, Alexander J Chou, Nai-Kong V Cheung. Front Oncol, 2015 Aug 25; 5. PMID: 26301204 Free PMC article. Review.
Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes. Feixiong Cheng, Junfei Zhao, Zhongming Zhao. Brief Bioinform, 2015 Aug 27; 17(4). PMID: 26307061 Free PMC article. Review.
Tumor infiltrating lymphocyte therapy for ovarian cancer and renal cell carcinoma. Rikke Andersen, Marco Donia, +3 authors, Inge Marie Svane. less Hum Vaccin Immunother, 2015 Aug 27; 11(12). PMID: 26308285 Free PMC article.
Strategies for combining immunotherapy with radiation for anticancer therapy. Steven N Seyedin, Jonathan E Schoenhals, +14 authors, James W Welsh. less Immunotherapy, 2015 Aug 28; 7(9). PMID: 26310908 Free PMC article. Review.
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Katherine B Chiappinelli, Pamela L Strissel, +20 authors, Reiner Strick. less Cell, 2015 Sep 01; 162(5). PMID: 26317466 Free PMC article. Highly Cited.
Antagonists of PD-1 and PD-L1 in Cancer Treatment. Evan J Lipson, Patrick M Forde, +3 authors, Suzanne L Topalian. less Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320063 Free PMC article. Highly Cited. Review.
The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment. Thomas F Gajewski. Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320069 Free PMC article. Highly Cited. Review.
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Xiaojuan Liu, Yang Pu, +7 authors, Meng Michelle Xu. less Nat Med, 2015 Sep 01; 21(10). PMID: 26322579 Free PMC article. Highly Cited.
Oncolytic viruses: a new class of immunotherapy drugs. Howard L Kaufman, Frederick J Kohlhapp, Andrew Zloza. Nat Rev Drug Discov, 2015 Sep 02; 14(9). PMID: 26323545 Free PMC article. Highly Cited. Review.
Immunity, inflammation, and cancer: an eternal fight between good and evil. Shabnam Shalapour, Michael Karin. J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325032 Free PMC article. Highly Cited. Review.
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade. Elizabeth Buchbinder, F Stephen Hodi. J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325034 Free PMC article. Review.
Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures. Soraya Curiel-Olmo, Almudena García-Castaño, +17 authors, José Vaqué. less Oncotarget, 2015 Sep 04; 6(28). PMID: 26327537 Free PMC article.
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. Anne Bertrand, Marie Kostine, +2 authors, Thierry Schaeverbeke. less BMC Med, 2015 Sep 05; 13. PMID: 26337719 Free PMC article. Highly Cited. Systematic Review.
A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme. Gilli Galore-Haskel, Yael Nemlich, +11 authors, Gal Markel. less Oncotarget, 2015 Sep 05; 6(30). PMID: 26338962 Free PMC article.
Germline determinants of clinical outcome of cutaneous melanoma. Matjaz Vogelsang, Melissa Wilson, Tomas Kirchhoff. Pigment Cell Melanoma Res, 2015 Sep 06; 29(1). PMID: 26342156 Free PMC article. Review.
Integrating Immune Checkpoint Blockade with Anti-Neo/Mutated Antigens Reactivity to Increase the Clinical Outcome of Immunotherapy. Giorgio Parmiani, Cristina Maccalli, Michele Maio. Vaccines (Basel), 2015 Sep 08; 3(2). PMID: 26343195 Free PMC article. Review.
The Promise of Preventive Cancer Vaccines. Pier-Luigi Lollini, Federica Cavallo, Patrizia Nanni, Elena Quaglino. Vaccines (Basel), 2015 Sep 08; 3(2). PMID: 26343198 Free PMC article. Review.
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. A Hunter Shain, Maria Garrido, +20 authors, Boris C Bastian. less Nat Genet, 2015 Sep 08; 47(10). PMID: 26343386 Free PMC article. Highly Cited.
Interest of Tumor-Specific CD4 T Helper 1 Cells for Therapeutic Anticancer Vaccine. Jeanne Galaine, Christophe Borg, Yann Godet, Olivier Adotévi. Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350591 Free PMC article. Review.
Systems Biology Approach for Cancer Vaccine Development and Evaluation. Luisa Circelli, Annacarmen Petrizzo, +3 authors, Luigi Buonaguro. less Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350594 Free PMC article. Review.
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Eliezer M Van Allen, Diana Miao, +19 authors, Levi A Garraway. less Science, 2015 Sep 12; 350(6257). PMID: 26359337 Free PMC article. Highly Cited.
Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Sonja Kleffel, Christian Posch, +19 authors, Tobias Schatton. less Cell, 2015 Sep 12; 162(6). PMID: 26359984 Free PMC article. Highly Cited.
Long term survival with cytotoxic T lymphocyte-associated antigen 4 blockade using tremelimumab. Zeynep Eroglu, Dae Won Kim, +9 authors, Antoni Ribas. less Eur J Cancer, 2015 Sep 15; 51(17). PMID: 26364516 Free PMC article.
Targeting the undruggable: immunotherapy meets personalized oncology in the genomic era. S D Martin, G Coukos, R A Holt, B H Nelson. Ann Oncol, 2015 Sep 16; 26(12). PMID: 26371284 Free PMC article. Review.
Immunotherapies for bladder cancer: a new hope. Farhad Fakhrejahani, Yusuke Tomita, +3 authors, Andrea B Apolo. less Curr Opin Urol, 2015 Sep 16; 25(6). PMID: 26372038 Free PMC article. Review.
Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. Luke S Manlove, Katherine E Berquam-Vrieze, +3 authors, Michael A Farrar. less J Immunol, 2015 Sep 18; 195(8). PMID: 26378075 Free PMC article.
Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma. Ahmad A Tarhini, Haris Zahoor, +4 authors, John M Kirkwood. less J Immunother Cancer, 2015 Sep 18; 3. PMID: 26380086 Free PMC article. Highly Cited.
Multiple structural and epigenetic defects in the human leukocyte antigen class I antigen presentation pathway in a recurrent metastatic melanoma following immunotherapy. Chien-Chung Chang, Giuseppe Pirozzi, +6 authors, Soldano Ferrone. less J Biol Chem, 2015 Sep 19; 290(44). PMID: 26381407 Free PMC article.
Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes. Cyrille J Cohen, Jared J Gartner, +11 authors, Paul F Robbins. less J Clin Invest, 2015 Sep 22; 125(10). PMID: 26389673 Free PMC article. Highly Cited.
Nivolumab in combination with ipilimumab for the treatment of melanoma. Rajasekharan Somasundaram, Meenhard Herlyn. Expert Rev Anticancer Ther, 2015 Sep 25; 15(10). PMID: 26402246 Free PMC article. Review.
Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology. Sandip P Patel, Maria Schwaederle, +10 authors, Razelle Kurzrock. less Oncotarget, 2015 Sep 30; 6(32). PMID: 26418953 Free PMC article.
MicroRNA MIR21 and T Cells in Colorectal Cancer. Kosuke Mima, Reiko Nishihara, +20 authors, Shuji Ogino. less Cancer Immunol Res, 2015 Oct 01; 4(1). PMID: 26419959 Free PMC article.
The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers. Brandon Leonard, Jennifer L McCann, +8 authors, Reuben S Harris. less Cancer Res, 2015 Oct 01; 75(21). PMID: 26420215 Free PMC article.
Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer. Guido Giordano, Antonio Febbraro, +13 authors, Massimo Pancione. less J Exp Clin Cancer Res, 2015 Oct 03; 34. PMID: 26427914 Free PMC article.
AACR Cancer Progress Report 2015. José Baselga, Nina Bhardwaj, +11 authors, Eva Szabo. less Clin Cancer Res, 2015 Oct 03; 21(19 Suppl). PMID: 26429991 Free PMC article.
TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst. Clemens Hermann, Andy van Hateren, +7 authors, Louise H Boyle. less Elife, 2015 Oct 07; 4. PMID: 26439010 Free PMC article.
Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice. Luís Felipe Campesato, Romualdo Barroso-Sousa, +6 authors, Anamaria A Camargo. less Oncotarget, 2015 Oct 07; 6(33). PMID: 26439694 Free PMC article. Highly Cited.
Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients. Aljosja Rogiers, Joost J van den Oord, +5 authors, Pascal Wolter. less Drugs Aging, 2015 Oct 08; 32(10). PMID: 26442859 Review.
Genetics and immunology: reinvigorated. Alexandra Snyder, Vladimir Makarov, +4 authors, Timothy A Chan. less Oncoimmunology, 2015 Oct 10; 4(10). PMID: 26451299 Free PMC article.
The influence of subclonal resistance mutations on targeted cancer therapy. Michael W Schmitt, Lawrence A Loeb, Jesse J Salk. Nat Rev Clin Oncol, 2015 Oct 21; 13(6). PMID: 26483300 Free PMC article. Highly Cited. Review.
The melanoma-specific graded prognostic assessment does not adequately discriminate prognosis in a modern population with brain metastases from malignant melanoma. Anna Wilkins, Andrew Furness, +6 authors, Kevin Harrington. less Br J Cancer, 2015 Oct 21; 113(9). PMID: 26484413 Free PMC article.
Immunological landscape and immunotherapy of hepatocellular carcinoma. Jesús Prieto, Ignacio Melero, Bruno Sangro. Nat Rev Gastroenterol Hepatol, 2015 Oct 21; 12(12). PMID: 26484443 Highly Cited. Review.
Predictive factors for immunotherapy in melanoma. Cristina Teixidó, Maria González-Cao, Niki Karachaliou, Rafael Rosell. Ann Transl Med, 2015 Oct 22; 3(15). PMID: 26488004 Free PMC article. Review.
Functional and genetic deconstruction of the cellular origin in liver cancer. Jens U Marquardt, Jesper B Andersen, Snorri S Thorgeirsson. Nat Rev Cancer, 2015 Oct 24; 15(11). PMID: 26493646 Highly Cited. Review.
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. David D Bowtell, Steffen Böhm, +38 authors, Frances R Balkwill. less Nat Rev Cancer, 2015 Oct 24; 15(11). PMID: 26493647 Free PMC article. Highly Cited. Review.
Molecular Dimensions of Gastric Cancer: Translational and Clinical Perspectives. Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong. J Pathol Transl Med, 2015 Oct 27; 50(1). PMID: 26498010 Free PMC article. Review.
Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy. Kelly Kersten, Camilla Salvagno, Karin E de Visser. Front Immunol, 2015 Oct 27; 6. PMID: 26500653 Free PMC article. Review.
Clinical Neuropathology mini-review 6-2015: PD-L1: emerging biomarker in glioblastoma? Matthias Preusser, Anna S Berghoff, Wolfgang Wick, Michael Weller. Clin Neuropathol, 2015 Oct 27; 34(6). PMID: 26501438 Free PMC article. Review.
Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing. Mark Klinger, Francois Pepin, +5 authors, Malek Faham. less PLoS One, 2015 Oct 29; 10(10). PMID: 26509579 Free PMC article.
Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy. David A Reardon, Mark R Gilbert, Wolfgang Wick, Linda Liau. Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516225 Free PMC article. Review.
Mutational profiling of colorectal cancers with microsatellite instability. Elaine I Lin, Li-Hui Tseng, +4 authors, James R Eshleman. less Oncotarget, 2015 Oct 31; 6(39). PMID: 26517354 Free PMC article.
Novel immunotherapies in lymphoid malignancies. Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes. Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683 Free PMC article. Highly Cited. Review.
Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery. Jianbin Wang, Joshua J DeClercq, +5 authors, Michael C Holmes. less Nucleic Acids Res, 2015 Nov 04; 44(3). PMID: 26527725 Free PMC article.
Phase I Clinical Trial of Ipilimumab in Pediatric Patients with Advanced Solid Tumors. Melinda S Merchant, Matthew Wright, +9 authors, Crystal L Mackall. less Clin Cancer Res, 2015 Nov 05; 22(6). PMID: 26534966 Free PMC article.
Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors? Andy Yingjie Lin, Edward Lin. J Hematol Oncol, 2015 Nov 07; 8. PMID: 26542241 Free PMC article.
DNA methylation subgroups in melanoma are associated with proliferative and immunological processes. Martin Lauss, Markus Ringnér, +6 authors, Göran Jönsson. less BMC Med Genomics, 2015 Nov 08; 8. PMID: 26545983 Free PMC article.
Cancer immunotherapy: Strategies for personalization and combinatorial approaches. Vishwanath Sathyanarayanan, Sattva S Neelapu. Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548534 Free PMC article. Review.
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Elizabeth I Buchbinder, Anupam Desai. Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876 Free PMC article. Highly Cited. Review.
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors. Karishma R Rajani, Richard G Vile. Viruses, 2015 Nov 19; 7(11). PMID: 26580645 Free PMC article. Review.
Immunogenomics: a foundation for intelligent immune design. Robert A Holt. Genome Med, 2015 Nov 20; 7(1). PMID: 26582413 Free PMC article.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression. Jelle Scholtalbers, Sebastian Boegel, +6 authors, John C Castle. less Genome Med, 2015 Nov 22; 7. PMID: 26589293 Free PMC article.
Landscape of Tumor Antigens in T Cell Immunotherapy. Sadia Ilyas, James C Yang. J Immunol, 2015 Nov 22; 195(11). PMID: 26589749 Free PMC article. Review.
Engineering opportunities in cancer immunotherapy. Laura Jeanbart, Melody A Swartz. Proc Natl Acad Sci U S A, 2015 Nov 26; 112(47). PMID: 26598681 Free PMC article. Review.
Combination cancer immunotherapies tailored to the tumour microenvironment. Mark J Smyth, Shin Foong Ngiow, Antoni Ribas, Michele W L Teng. Nat Rev Clin Oncol, 2015 Nov 26; 13(3). PMID: 26598942 Highly Cited. Review.
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Madhav D Sharma, Rahul Shinde, +12 authors, David H Munn. less Sci Adv, 2015 Nov 26; 1(10). PMID: 26601142 Free PMC article. Highly Cited.
Immune checkpoint inhibitors: therapeutic advances in melanoma. Ivan Márquez-Rodas, Pablo Cerezuela, +4 authors, Salvador Martín-Algarra. less Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605313 Free PMC article. Review.
Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells. David A Quigley, Vessela Kristensen. Mol Oncol, 2015 Nov 27; 9(10). PMID: 26607741 Free PMC article. Review.
Precision Medicine for Molecularly Targeted Agents and Immunotherapies in Early-Phase Clinical Trials. Juanita Lopez, Sam Harris, Desam Roda, Timothy A Yap. Transl Oncogenomics, 2015 Nov 27; 7(Suppl 1). PMID: 26609214 Free PMC article. Review.
Immune suppressive mechanisms in the tumor microenvironment. David H Munn, Vincenzo Bronte. Curr Opin Immunol, 2015 Nov 27; 39. PMID: 26609943 Free PMC article. Highly Cited. Review.
Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014. Paolo A Ascierto, Michael Atkins, +34 authors, Magdalena Thurin. less J Transl Med, 2015 Dec 02; 13. PMID: 26619946 Free PMC article.
Future directions in the treatment of osteosarcoma. Michael W Bishop, Katherine A Janeway, Richard Gorlick. Curr Opin Pediatr, 2015 Dec 03; 28(1). PMID: 26626558 Free PMC article. Highly Cited. Review.
Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer. David M Langenau, Alejandro Sweet-Cordero, Robert Wechsler-Reya, Michael A Dyer. Cancer Res, 2015 Dec 03; 75(24). PMID: 26627009 Free PMC article. Review.
Novel therapies in small cell lung cancer. Hirva Mamdani, Raghava Induru, Shadia I Jalal. Transl Lung Cancer Res, 2015 Dec 03; 4(5). PMID: 26629422 Free PMC article. Review.
New strategies in immunotherapy for non-small cell lung cancer. Daniel R Carrizosa, Kathryn A Gold. Transl Lung Cancer Res, 2015 Dec 03; 4(5). PMID: 26629424 Free PMC article. Review.
Immunomonitoring in glioma immunotherapy: current status and future perspectives. Jonathan B Lamano, Leonel Ampie, +5 authors, Orin Bloch. less J Neurooncol, 2015 Dec 08; 127(1). PMID: 26638171 Free PMC article. Review.
Cancer immunotherapy targeting neoantigens. Yong-Chen Lu, Paul F Robbins. Semin Immunol, 2015 Dec 15; 28(1). PMID: 26653770 Free PMC article. Highly Cited. Review.
Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy. Gerald Goh, Trent Walradt, +11 authors, Jaehyuk Choi. less Oncotarget, 2015 Dec 15; 7(3). PMID: 26655088 Free PMC article. Highly Cited.
Mismatch repair deficiency associated with complete remission to combination programmed cell death ligand immune therapy in a patient with sporadic urothelial carcinoma: immunotheranostic considerations. Michael P Castro, Neal Goldstein. J Immunother Cancer, 2015 Dec 18; 3. PMID: 26674132 Free PMC article.
Importance of immunopharmacogenomics in cancer treatment: Patient selection and monitoring for immune checkpoint antibodies. Noura Choudhury, Yusuke Nakamura. Cancer Sci, 2015 Dec 19; 107(2). PMID: 26678880 Free PMC article. Review.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy. Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake. Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632 Free PMC article. Review.
Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches. Clint T Allen, Paul E Clavijo, Carter Van Waes, Zhong Chen. Cancers (Basel), 2015 Dec 23; 7(4). PMID: 26690220 Free PMC article. Review.
Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors. Qiong J Wang, Zhiya Yu, +3 authors, James C Yang. less Cancer Immunol Res, 2015 Dec 25; 4(3). PMID: 26701267 Free PMC article.
Predictors of clinical response to immunotherapy with or without radiotherapy. Susan M Hiniker, Holden T Maecker, Susan J Knox. J Radiat Oncol, 2015 Dec 29; 4. PMID: 26709361 Free PMC article. Review.
Prospects for gene-engineered T cell immunotherapy for solid cancers. Christopher A Klebanoff, Steven A Rosenberg, Nicholas P Restifo. Nat Med, 2016 Jan 07; 22(1). PMID: 26735408 Free PMC article. Highly Cited.
Epigenetic Therapeutics: A New Weapon in the War Against Cancer. Nita Ahuja, Anup R Sharma, Stephen B Baylin. Annu Rev Med, 2016 Jan 16; 67. PMID: 26768237 Free PMC article. Highly Cited. Review.
Potential biomarker for checkpoint blockade immunotherapy and treatment strategy. Zhong-Yi Dong, Si-Pei Wu, +2 authors, Ri-Qiang Liao, Shu-Mei Huang, Yi-Long Wu. less Tumour Biol, 2016 Jan 19; 37(4). PMID: 26779629 Review.
Melanoma in 2015: Immune-checkpoint blockade - durable cancer control. Elizabeth I Buchbinder, F Stephen Hodi. Nat Rev Clin Oncol, 2016 Jan 21; 13(2). PMID: 26787285
Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab. Alexander Martens, Kilian Wistuba-Hamprecht, +21 authors, Benjamin Weide. less Clin Cancer Res, 2016 Jan 21; 22(12). PMID: 26787752 Free PMC article. Highly Cited.
Novel technologies and emerging biomarkers for personalized cancer immunotherapy. Jianda Yuan, Priti S Hegde, +16 authors, Bernard A Fox. less J Immunother Cancer, 2016 Jan 21; 4. PMID: 26788324 Free PMC article. Highly Cited. Review.
Integrating the molecular background of targeted therapy and immunotherapy in lung cancer: a way to explore the impact of mutational landscape on tumor immunogenicity. Sara Pilotto, Miguel Angel Molina-Vila, +6 authors, Rafael Rosell. less Transl Lung Cancer Res, 2016 Jan 23; 4(6). PMID: 26798581 Free PMC article. Review.
Shedding light on the molecular determinants of response to anti-PD-1 therapy. Ross A Soo. Transl Lung Cancer Res, 2016 Jan 23; 4(6). PMID: 26798594 Free PMC article.
Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. Katsuhiko Nosho, Yasutaka Sukawa, +11 authors, Yasuhisa Shinomura. less World J Gastroenterol, 2016 Jan 27; 22(2). PMID: 26811607 Free PMC article. Highly Cited. Review.
Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy. Douglas B Johnson, Monica V Estrada, +18 authors, Justin M Balko. less Nat Commun, 2016 Jan 30; 7. PMID: 26822383 Free PMC article. Highly Cited.
A panoply of errors: polymerase proofreading domain mutations in cancer. Emily Rayner, Inge C van Gool, +4 authors, David N Church. less Nat Rev Cancer, 2016 Jan 30; 16(2). PMID: 26822575 Highly Cited. Review.
Acquired resistance to immunotherapy and future challenges. Nicholas P Restifo, Mark J Smyth, Alexandra Snyder. Nat Rev Cancer, 2016 Jan 30; 16(2). PMID: 26822578 Free PMC article. Highly Cited.
Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen. Elena Shklovskaya, Alexandra M Terry, +5 authors, Barbara Fazekas de St. Groth. less Immunol Cell Biol, 2016 Feb 04; 94(6). PMID: 26837456
Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival. Luc G T Morris, Nadeem Riaz, +5 authors, Timothy A Chan. less Oncotarget, 2016 Feb 04; 7(9). PMID: 26840267 Free PMC article. Highly Cited.
Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination. Mathias Vormehr, Barbara Schrörs, +3 authors, Ugur Sahin. less J Immunol Res, 2016 Feb 05; 2015. PMID: 26844233 Free PMC article. Review.
Mutations as munitions: Neoantigen vaccines get a closer look as cancer treatment. Alla Katsnelson. Nat Med, 2016 Feb 06; 22(2). PMID: 26845402
Advances in immunotherapy for melanoma. Jason M Redman, Geoffrey T Gibney, Michael B Atkins. BMC Med, 2016 Feb 07; 14. PMID: 26850630 Free PMC article. Highly Cited. Review.
Immunotherapy and Oncogenic Pathways: The PTEN Connection. Naiyer A Rizvi, Timothy A Chan. Cancer Discov, 2016 Feb 07; 6(2). PMID: 26851183 Free PMC article.
Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma. Yanyan Lou, Lixia Diao, +12 authors, Don L Gibbons. less Clin Cancer Res, 2016 Feb 07; 22(14). PMID: 26851185 Free PMC article. Highly Cited.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella. Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028 Free PMC article. Review.
Combination Therapies for Melanoma: A New Standard of Care? Keiran S M Smalley, Zeynep Eroglu, Vernon K Sondak. Am J Clin Dermatol, 2016 Feb 11; 17(2). PMID: 26860106 Free PMC article. Review.
Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck. Johannes A Veit, Daniela Heine, +12 authors, Simon Laban. less Head Neck, 2016 Feb 14; 38(7). PMID: 26874246 Free PMC article.
Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma. Katherine Woods, Ashley J Knights, +4 authors, Jonathan Cebon. less J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885372 Free PMC article.
PD-1/PD-L1 blockade in cancer treatment: perspectives and issues. Junzo Hamanishi, Masaki Mandai, +3 authors, Ikuo Konishi. less Int J Clin Oncol, 2016 Feb 24; 21(3). PMID: 26899259 Free PMC article. Highly Cited. Review.
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Alena Gros, Maria R Parkhurst, +11 authors, Steven A Rosenberg. less Nat Med, 2016 Feb 24; 22(4). PMID: 26901407 Free PMC article. Highly Cited.
Emerging Tissue and Blood-Based Biomarkers that may Predict Response to Immune Checkpoint Inhibition. Claire F Friedman, Michael A Postow. Curr Oncol Rep, 2016 Feb 29; 18(4). PMID: 26922327 Free PMC article. Review.
The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer. Jeffrey P Ward, Matthew M Gubin, Robert D Schreiber. Adv Immunol, 2016 Mar 01; 130. PMID: 26922999 Free PMC article. Highly Cited. Review.
Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities. K M Morrissey, T M Yuraszeck, +2 authors, C-C Li, Y Zhang, S Kasichayanula. less Clin Transl Sci, 2016 Mar 01; 9(2). PMID: 26924066 Free PMC article. Highly Cited. Review.
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Nicholas McGranahan, Andrew J S Furness, +33 authors, Charles Swanton. less Science, 2016 Mar 05; 351(6280). PMID: 26940869 Free PMC article. Highly Cited.
Activation of cytomegalovirus-specific CD8+ T-cell response by antibody-mediated peptide-major histocompatibility class I complexes. Martina Schmittnaegel, Christian Klein, Victor Levitsky, Hendrik Knoetgen. Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942061 Free PMC article.
Doubling the blockade for melanoma immunotherapy. Lorenzo Galluzzi, Alexander Eggermont, Guido Kroemer. Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942094 Free PMC article.
Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections. Maria Lina Tornesello, Luigi Buonaguro, Francesco Izzo, Franco M Buonaguro. Oncotarget, 2016 Mar 05; 7(18). PMID: 26943571 Free PMC article. Review.
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Jonathan E Rosenberg, Jean Hoffman-Censits, +28 authors, Robert Dreicer. less Lancet, 2016 Mar 10; 387(10031). PMID: 26952546 Free PMC article. Highly Cited.
Cellular and molecular biology of small cell lung cancer: an overview. Niki Karachaliou, Sara Pilotto, +3 authors, Rafael Rosell. less Transl Lung Cancer Res, 2016 Mar 10; 5(1). PMID: 26958489 Free PMC article. Review.
Vaccines for established cancer: overcoming the challenges posed by immune evasion. Sjoerd H van der Burg, Ramon Arens, +2 authors, Ferry Ossendorp, Thorbald van Hall, Cornelis J M Melief. less Nat Rev Cancer, 2016 Mar 12; 16(4). PMID: 26965076 Highly Cited. Review.
Versatile roles of extracellular vesicles in cancer. Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya. J Clin Invest, 2016 Mar 15; 126(4). PMID: 26974161 Free PMC article. Highly Cited. Review.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok. Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780 Free PMC article. Highly Cited. Review.
Melanoma Cancer Stem Cells: Markers and Functions. Giorgio Parmiani. Cancers (Basel), 2016 Mar 16; 8(3). PMID: 26978405 Free PMC article. Review.
Improving Systemic Chemotherapy for Bladder Cancer. Tracy L Rose, Matthew I Milowsky. Curr Oncol Rep, 2016 Mar 18; 18(5). PMID: 26984414 Review.
FDA Approval Summary: Nivolumab for the Treatment of Metastatic Non-Small Cell Lung Cancer With Progression On or After Platinum-Based Chemotherapy. Dickran Kazandjian, Daniel L Suzman, +5 authors, Richard Pazdur. less Oncologist, 2016 Mar 18; 21(5). PMID: 26984449 Free PMC article. Highly Cited.
Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer. Edward J Fox, Jesse J Salk, Lawrence A Loeb. Genome Med, 2016 Mar 19; 8(1). PMID: 26987311 Free PMC article.
Combining Epigenetic and Immunotherapy to Combat Cancer. Katherine B Chiappinelli, Cynthia A Zahnow, Nita Ahuja, Stephen B Baylin. Cancer Res, 2016 Mar 19; 76(7). PMID: 26988985 Free PMC article. Highly Cited. Review.
Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment. Stefani Spranger. Int Immunol, 2016 Mar 19; 28(8). PMID: 26989092 Free PMC article. Highly Cited. Review.
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma. Willy Hugo, Jesse M Zaretsky, +15 authors, Roger S Lo. less Cell, 2016 Mar 22; 165(1). PMID: 26997480 Free PMC article. Highly Cited.
Genomic landscape of DNA repair genes in cancer. Young Kwang Chae, Jonathan F Anker, +6 authors, Francis J Giles. less Oncotarget, 2016 Mar 24; 7(17). PMID: 27004405 Free PMC article. Highly Cited.
Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer. Pietro Parcesepe, Guido Giordano, +2 authors, Carmelo Laudanna, Antonio Febbraro, Massimo Pancione. less Gastroenterol Res Pract, 2016 Mar 24; 2016. PMID: 27006653 Free PMC article. Review.
Case report: mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance. Kuo-Hsing Chen, Chang-Tsu Yuan, +2 authors, Li-Hui Tseng, Chia-Tung Shun, Kun-Huei Yeh. less J Hematol Oncol, 2016 Mar 26; 9. PMID: 27012666 Free PMC article.
Clinical utility of nivolumab in the treatment of advanced melanoma. Ramsey Asmar, Jessica Yang, Richard D Carvajal. Ther Clin Risk Manag, 2016 Mar 26; 12. PMID: 27013881 Free PMC article. Review.
Targeting persistent androgen receptor signaling in castration-resistant prostate cancer. Laura Graham, Michael T Schweizer. Med Oncol, 2016 Apr 05; 33(5). PMID: 27042852 Review.
The role of neoantigens in response to immune checkpoint blockade. Nadeem Riaz, Luc Morris, +3 authors, Timothy A Chan. less Int Immunol, 2016 Apr 07; 28(8). PMID: 27048318 Free PMC article. Review.
Immunological markers and clinical outcome of advanced melanoma patients receiving ipilimumab plus fotemustine in the NIBIT-M1 study. Cristina Maccalli, Diana Giannarelli, +5 authors, Michele Maio. less Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057436 Free PMC article.
Trial Watch-Immunostimulation with cytokines in cancer therapy. Erika Vacchelli, Fernando Aranda, +10 authors, Lorenzo Galluzzi. less Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057468 Free PMC article. Review.
Carfilzomib alters the HLA-presented peptidome of myeloma cells and impairs presentation of peptides with aromatic C-termini. D J Kowalewski, S Walz, +9 authors, J S Stickel. less Blood Cancer J, 2016 Apr 09; 6. PMID: 27058226 Free PMC article.
Opportunities for immunotherapy in microsatellite instable colorectal cancer. Harm Westdorp, Felix L Fennemann, +7 authors, I Jolanda M de Vries. less Cancer Immunol Immunother, 2016 Apr 10; 65(10). PMID: 27060000 Free PMC article. Review.
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Suzanne L Topalian, Janis M Taube, Robert A Anders, Drew M Pardoll. Nat Rev Cancer, 2016 Apr 16; 16(5). PMID: 27079802 Free PMC article. Highly Cited. Review.
Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum. Douglas B Johnson, Jason Roszik, +7 authors, Scott E Woodman. less Pigment Cell Melanoma Res, 2016 Apr 19; 29(4). PMID: 27089234 Free PMC article.
Kirsten Ras* oncogene: significance of its discovery in human cancer research. Nobuo Tsuchida, Avaniyapuram Kannan Murugan, Michele Grieco. Oncotarget, 2016 Apr 23; 7(29). PMID: 27102293 Free PMC article. Review.
Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy. Rajarsi Mandal, Timothy A Chan. Cancer Discov, 2016 Apr 24; 6(7). PMID: 27107038 Free PMC article. Review.
Immune Checkpoint Therapy and the Search for Predictive Biomarkers. Padmanee Sharma. Cancer J, 2016 Apr 26; 22(2). PMID: 27111900 Free PMC article. Review.
Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity. Thomas V Guy, Alexandra M Terry, +6 authors, Barbara Fazekas de St. Groth. less Oncotarget, 2016 Apr 29; 7(21). PMID: 27121060 Free PMC article.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Itay Tirosh, Benjamin Izar, +34 authors, Levi A Garraway. less Science, 2016 Apr 29; 352(6282). PMID: 27124452 Free PMC article. Highly Cited.
Prime time for immune-checkpoint targeted therapy at ASCO 2015. Aurélien Marabelle, Bertrand Routy, +2 authors, Judith Michels, Guido Kroemer, Laurence Zitvogel. less Oncoimmunology, 2016 May 04; 5(3). PMID: 27141332 Free PMC article. Review.
POLE proofreading mutation, immune response and prognosis in endometrial cancer. Inge C van Gool, Tjalling Bosse, David N Church. Oncoimmunology, 2016 May 04; 5(3). PMID: 27141333 Free PMC article.
Tumor-intrinsic oncogene pathways mediating immune avoidance. Stefani Spranger, Thomas F Gajewski. Oncoimmunology, 2016 May 04; 5(3). PMID: 27141343 Free PMC article. Highly Cited. Review.
Immunological correlates of treatment and response in stage IV malignant melanoma patients treated with Ipilimumab. Jon Bjoern, Nikolaj Juul Nitschke, +3 authors, Inge Marie Svane. less Oncoimmunology, 2016 May 04; 5(4). PMID: 27141381 Free PMC article.
Changing paradigm of cancer therapy: precision medicine by next-generation sequencing. Yuan Xue, William R Wilcox. Cancer Biol Med, 2016 May 05; 13(1). PMID: 27144059 Free PMC article.
Clinical Implementation of Novel Targeted Therapeutics in Advanced Breast Cancer. Mary D Chamberlin, Erica B Bernhardt, Todd W Miller. J Cell Biochem, 2016 May 06; 117(11). PMID: 27146558 Free PMC article. Review.
Nature Biotechnology's academic spinouts of 2015. Aaron Bouchie, Laura DeFrancesco. Nat Biotechnol, 2016 May 08; 34(5). PMID: 27153278
Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer. Janice M Mehnert, Anshuman Panda, +16 authors, Shridar Ganesan. less J Clin Invest, 2016 May 10; 126(6). PMID: 27159395 Free PMC article. Highly Cited.
Roles of regulatory T cells in cancer immunity. Yoshiko Takeuchi, Hiroyoshi Nishikawa. Int Immunol, 2016 May 11; 28(8). PMID: 27160722 Free PMC article. Highly Cited. Review.
The Present and Future of Biomarkers in Prostate Cancer: Proteomics, Genomics, and Immunology Advancements. Pierre-Olivier Gaudreau, John Stagg, Denis Soulières, Fred Saad. Biomark Cancer, 2016 May 12; 8(Suppl 2). PMID: 27168728 Free PMC article. Review.
Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab. Alexander Martens, Kilian Wistuba-Hamprecht, +15 authors, Benjamin Weide. less Clin Cancer Res, 2016 May 14; 22(19). PMID: 27169993 Free PMC article. Highly Cited.
BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells. Norihiro Ueda, Rong Zhang, +13 authors, Yasushi Uemura. less Cell Mol Immunol, 2016 May 18; 15(1). PMID: 27181332 Free PMC article.
Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity. Luke S Manlove, Jason M Schenkel, +4 authors, Michael A Farrar. less J Immunol, 2016 May 18; 196(11). PMID: 27183622 Free PMC article.
Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab. Benjamin Weide, Alexander Martens, +24 authors, Jedd D Wolchok. less Clin Cancer Res, 2016 Nov 01; 22(22). PMID: 27185375 Free PMC article. Highly Cited.
Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines. Spencer D Martin, Scott D Brown, +5 authors, Brad H Nelson. less PLoS One, 2016 May 19; 11(5). PMID: 27192170 Free PMC article. Highly Cited.
Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness. Lance D Miller, Jeff A Chou, +13 authors, Francesco M Marincola. less Cancer Immunol Res, 2016 May 20; 4(7). PMID: 27197066 Free PMC article.
Burden of Nonsynonymous Mutations among TCGA Cancers and Candidate Immune Checkpoint Inhibitor Responses. Leandro M Colli, Mitchell J Machiela, +3 authors, Timothy A Myers, Lea Jessop, Kai Yu, Stephen J Chanock. less Cancer Res, 2016 May 20; 76(13). PMID: 27197178 Free PMC article. Highly Cited.
Targeting neoantigens for cancer immunotherapy. Yong-Chen Lu, Paul F Robbins. Int Immunol, 2016 May 22; 28(7). PMID: 27208041 Free PMC article. Review.
Future paradigms for precision oncology. Giannoula Lakka Klement, Knarik Arkun, +20 authors, Jaroslav Sterba. less Oncotarget, 2016 May 26; 7(29). PMID: 27223079 Free PMC article. Review.
Immunotherapy in glioblastoma: emerging options in precision medicine. Tiffany R Hodges, Sherise D Ferguson, Amy B Heimberger. CNS Oncol, 2016 May 27; 5(3). PMID: 27225028 Free PMC article. Review.
Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection? Lucia Festino, Gerardo Botti, +5 authors, Paolo A Ascierto. less Drugs, 2016 May 28; 76(9). PMID: 27229745 Highly Cited. Review.
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy. Weijie Ma, Barbara M Gilligan, Jianda Yuan, Tianhong Li. J Hematol Oncol, 2016 May 29; 9(1). PMID: 27234522 Free PMC article. Highly Cited. Review.
Checkpoint Inhibitors and Their Application in Breast Cancer. Davide Bedognetti, Cristina Maccalli, +2 authors, Barbara Seliger. less Breast Care (Basel), 2016 May 31; 11(2). PMID: 27239172 Free PMC article. Review.
Monitoring immune responses in the tumor microenvironment. Jennifer A Wargo, Sangeetha M Reddy, Alexandre Reuben, Padmanee Sharma. Curr Opin Immunol, 2016 May 31; 41. PMID: 27240055 Free PMC article. Review.
A second chance for telomerase reverse transcriptase in anticancer immunotherapy. Maurizio Zanetti. Nat Rev Clin Oncol, 2016 Nov 03; 14(2). PMID: 27245281 Review.
Translational and clinical implications of the genetic landscape of prostate cancer. Daniel E Spratt, Zachary S Zumsteg, Felix Y Feng, Scott A Tomlins. Nat Rev Clin Oncol, 2016 Jun 02; 13(10). PMID: 27245282 Free PMC article. Review.
Development and clinical application of an integrative genomic approach to personalized cancer therapy. Andrew V Uzilov, Wei Ding, +41 authors, Rong Chen. less Genome Med, 2016 Jun 02; 8(1). PMID: 27245685 Free PMC article.
When Genome Maintenance Goes Badly Awry. Elizabeth M Kass, Mary Ellen Moynahan, Maria Jasin. Mol Cell, 2016 Jun 04; 62(5). PMID: 27259208 Free PMC article. Review.
Biological markers of prognosis, response to therapy and outcome in ovarian carcinoma. Marta Szajnik, Małgorzata Czystowska-Kuźmicz, Esther Elishaev, Theresa L Whiteside. Expert Rev Mol Diagn, 2016 Jun 09; 16(8). PMID: 27268121 Free PMC article. Review.
[Molecular and immunohistochemical diagnostics in melanoma]. B Schilling, K G Griewank. Hautarzt, 2016 Jun 09; 67(7). PMID: 27270408 Review.
What does the future hold for immunotherapy in cancer? Jarushka Naidoo, Bob T Li, Katja Schindler, David B Page. Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275490 Free PMC article.
RNA splicing factors as oncoproteins and tumour suppressors. Heidi Dvinge, Eunhee Kim, Omar Abdel-Wahab, Robert K Bradley. Nat Rev Cancer, 2016 Jun 11; 16(7). PMID: 27282250 Free PMC article. Highly Cited. Review.
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade. Pei-Ling Chen, Whijae Roh, +41 authors, Jennifer A Wargo. less Cancer Discov, 2016 Jun 16; 6(8). PMID: 27301722 Free PMC article. Highly Cited.
Genomic profile, smoking, and response to anti-PD-1 therapy in non-small cell lung carcinoma. Matthew Hellmann, Naiyer Rizvi, Jedd D Wolchok, Timothy A Chan. Mol Cell Oncol, 2016 Jun 17; 3(1). PMID: 27308563 Free PMC article.
Analysis of PD-L1, T-cell infiltrate and HLA expression in chondrosarcoma indicates potential for response to immunotherapy specifically in the dedifferentiated subtype. Marie Kostine, Arjen Hg Cleven, +3 authors, Judith V M G Bovée. less Mod Pathol, 2016 Jun 18; 29(9). PMID: 27312065
Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens. Todd D Prickett, Jessica S Crystal, +11 authors, Paul F Robbins. less Cancer Immunol Res, 2016 Jun 18; 4(8). PMID: 27312342 Free PMC article.
Deficient Mismatch Repair and the Role of Immunotherapy in Metastatic Colorectal Cancer. Dionisia Quiroga, H Kim Lyerly, Michael A Morse. Curr Treat Options Oncol, 2016 Jun 18; 17(8). PMID: 27315067 Review.
Checkpoint inhibitors and other novel immunotherapies for advanced renal cell carcinoma. Maria I Carlo, Martin H Voss, Robert J Motzer. Nat Rev Urol, 2016 Jun 22; 13(7). PMID: 27324121 Free PMC article. Review.
Molecular characterisation of cutaneous melanoma: creating a framework for targeted and immune therapies. Shivshankari Rajkumar, Ian R Watson. Br J Cancer, 2016 Jun 24; 115(2). PMID: 27336610 Free PMC article. Review.
MonoSeq Variant Caller Reveals Novel Mononucleotide Run Indel Mutations in Tumors with Defective DNA Mismatch Repair. Christopher J Walker, Mario A Miranda, +10 authors, Paul J Goodfellow. less Hum Mutat, 2016 Jun 28; 37(10). PMID: 27346418 Free PMC article.
Immune checkpoint inhibitor combinations in solid tumors: opportunities and challenges. Chrisann Kyi, Michael A Postow. Immunotherapy, 2016 Jun 29; 8(7). PMID: 27349981 Free PMC article. Highly Cited. Review.
CTLA-4 Limits Anti-CD20-Mediated Tumor Regression. Zhenhua Ren, Jingya Guo, +7 authors, Yang-Xin Fu. less Clin Cancer Res, 2016 Jun 30; 23(1). PMID: 27354469 Free PMC article.
The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints. Santosha Vardhana, Anas Younes. Haematologica, 2016 Jul 02; 101(7). PMID: 27365459 Free PMC article. Review.
Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies. Sarah T Garber, Yuuri Hashimoto, +10 authors, Amy B Heimberger. less Neuro Oncol, 2016 Jul 03; 18(10). PMID: 27370400 Free PMC article. Highly Cited.
Inhibiting Immune Checkpoints for the Treatment of Bladder Cancer. S Bidnur, R Savdie, P C Black. Bladder Cancer, 2016 Jul 05; 2(1). PMID: 27376121 Free PMC article. Review.
Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas. Natalie Vandeven, Paul Nghiem. Immunotherapy, 2016 Jul 07; 8(8). PMID: 27381685 Free PMC article. Review.
Clinician Perspectives on Current Issues in Lung Cancer Drug Development. Saiama N Waqar, Philip D Bonomi, +17 authors, Gideon M Blumenthal. less J Thorac Oncol, 2016 Jul 13; 11(9). PMID: 27401214 Free PMC article. Review.
Merkel Cell Carcinoma: An Unusually Immunogenic Cancer Proves Ripe for Immune Therapy. Natalie A Vandeven, Paul Nghiem. J Oncol Pract, 2016 Jul 14; 12(7). PMID: 27407162 Free PMC article.
Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade. Valerie Lee, Adrian Murphy, Dung T Le, Luis A Diaz. Oncologist, 2016 Jul 15; 21(10). PMID: 27412392 Free PMC article. Highly Cited. Review.
Metastatic melanoma and immunotherapy. Benjamin Herzberg, David E Fisher. Clin Immunol, 2016 Jul 20; 172. PMID: 27430520 Free PMC article. Review.
Tumor infiltrating lymphocytes and PD-L1 expression in brain metastases of small cell lung cancer (SCLC). Anna Sophie Berghoff, Gerda Ricken, +6 authors, Matthias Preusser. less J Neurooncol, 2016 Oct 21; 130(1). PMID: 27436101
Stem-like features of cancer cells on their way to metastasis. Sofia Gkountela, Nicola Aceto. Biol Direct, 2016 Jul 28; 11. PMID: 27457474 Free PMC article. Review.
Immuno-oncology combinations: raising the tail of the survival curve. Samuel J Harris, Jessica Brown, Juanita Lopez, Timothy A Yap. Cancer Biol Med, 2016 Jul 28; 13(2). PMID: 27458526 Free PMC article.
The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine. Andrea Garofalo, Lynette Sholl, +18 authors, Eliezer M Van Allen. less Genome Med, 2016 Jul 28; 8(1). PMID: 27460824 Free PMC article. Highly Cited.
Characterization of the T-cell receptor beta chain repertoire in tumor-infiltrating lymphocytes. Katsumi Nakanishi, Yoji Kukita, +3 authors, Kikuya Kato. less Cancer Med, 2016 Jul 29; 5(9). PMID: 27465739 Free PMC article.
Melanoma driver mutations and immune therapy. Douglas B Johnson, Christine M Lovly, +2 authors, Ryan J Sullivan, Richard D Carvajal, Jeffrey A Sosman. less Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467925 Free PMC article.
Cripto-1 vaccination elicits protective immunity against metastatic melanoma. M A Ligtenberg, K Witt, +4 authors, R Kiessling. less Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467944 Free PMC article.
PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors. Adrian M Seifert, Shan Zeng, +11 authors, Ronald P DeMatteo. less Clin Cancer Res, 2016 Jul 30; 23(2). PMID: 27470968 Free PMC article.
Prioritization schema for immunotherapy clinical trials in glioblastoma. Tiffany R Hodges, Sherise D Ferguson, +17 authors, Amy B Heimberger. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471611 Free PMC article. Review.
SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade. Wei Xue, Rachael L Metheringham, +5 authors, Lindy G Durrant. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471648 Free PMC article.
Molecular profiling of neuroendocrine malignancies to identify prognostic and therapeutic markers: a Fox Chase Cancer Center Pilot Study. Namrata Vijayvergia, Patrick M Boland, +7 authors, Paul F Engstrom. less Br J Cancer, 2016 Aug 03; 115(5). PMID: 27482646 Free PMC article.
Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients. Teofila Seremet, Alexander Koch, +12 authors, Bart Neyns. less J Transl Med, 2016 Aug 04; 14(1). PMID: 27484791 Free PMC article.
The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment. Sara I Pai, Dan P Zandberg, Scott E Strome. Oral Oncol, 2016 Aug 10; 61. PMID: 27503244 Free PMC article. Review.
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis. Andrea Schietinger, Mary Philip, +10 authors, Philip D Greenberg. less Immunity, 2016 Aug 16; 45(2). PMID: 27521269 Free PMC article. Highly Cited.
Circulating protein and antibody biomarker for personalized cancer immunotherapy. Jianda Yuan. J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532021 Free PMC article.
PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction? Claud Grigg, Naiyer A Rizvi. J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532023 Free PMC article. Highly Cited. Review.
Clinical outcomes in metastatic uveal melanoma treated with PD-1 and PD-L1 antibodies. Alain P Algazi, Katy K Tsai, +13 authors, Ryan J Sullivan. less Cancer, 2016 Oct 21; 122(21). PMID: 27533448 Free PMC article. Highly Cited.
The efficacy of anti-PD-1 agents in acral and mucosal melanoma. Alexander N Shoushtari, Rodrigo R Munhoz, +17 authors, Michael A Postow. less Cancer, 2016 Oct 21; 122(21). PMID: 27533633 Free PMC article. Highly Cited.
Tumor Mutational Load and Immune Parameters across Metastatic Renal Cell Carcinoma Risk Groups. Guillermo de Velasco, Diana Miao, +8 authors, Toni K Choueiri. less Cancer Immunol Res, 2016 Aug 20; 4(10). PMID: 27538576 Free PMC article.
Current Progress in Immunotherapy for the Treatment of Biliary Cancers. James M Pauff, Laura W Goff. J Gastrointest Cancer, 2016 Aug 20; 47(4). PMID: 27538880 Review.
FGFR1 inhibition in lung squamous cell carcinoma: questions and controversies. C E Weeden, B Solomon, M-L Asselin-Labat. Cell Death Discov, 2015 Jan 01; 1. PMID: 27551478 Free PMC article. Review.
Neoantigen-based cancer immunotherapy. Sara Bobisse, Periklis G Foukas, George Coukos, Alexandre Harari. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563649 Free PMC article. Review.
Towards tumor immunodiagnostics. Helen Kourea, Vassiliki Kotoula. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563650 Free PMC article. Review.
DNA damage, tumor mutational load and their impact on immune responses against cancer. Michalis Liontos, Ioannis Anastasiou, Aristotelis Bamias, Meletios-Athanasios Dimopoulos. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563651 Free PMC article. Review.
Optimized tumor cryptic peptides: the basis for universal neo-antigen-like tumor vaccines. Jeanne Menez-Jamet, Catherine Gallou, Aude Rougeot, Kostas Kosmatopoulos. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563653 Free PMC article. Review.
The European Organization for Research and Treatment of Cancer perspective on designing clinical trials with immune therapeutics. Jessica Menis, Saskia Litière, Konstantinos Tryfonidis, Vassilis Golfinopoulos. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563654 Free PMC article. Review.
A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling. Heather L McArthur, Adi Diab, +27 authors, Larry Norton. less Clin Cancer Res, 2016 Nov 05; 22(23). PMID: 27566765 Free PMC article.
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes. Amalie Kai Bentzen, Andrea Marion Marquard, +15 authors, Sine Reker Hadrup. less Nat Biotechnol, 2016 Aug 30; 34(10). PMID: 27571370 Highly Cited.
Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine. Minmin Liu, Hitoshi Ohtani, +8 authors, Peter A Jones. less Proc Natl Acad Sci U S A, 2016 Aug 31; 113(37). PMID: 27573823 Free PMC article. Highly Cited.
GBM-associated mutations and altered protein expression are more common in young patients. Sherise D Ferguson, Joanne Xiu, +8 authors, Amy B Heimberger. less Oncotarget, 2016 Sep 01; 7(43). PMID: 27579614 Free PMC article.
Strategies to modulate the immune system in breast cancer: checkpoint inhibitors and beyond. Cristina Migali, Monica Milano, +5 authors, Giuseppe Curigliano. less Ther Adv Med Oncol, 2016 Sep 02; 8(5). PMID: 27583028 Free PMC article. Review.
Concordance between genomic alterations assessed by next-generation sequencing in tumor tissue or circulating cell-free DNA. Young Kwang Chae, Andrew A Davis, +11 authors, Francis J Giles. less Oncotarget, 2016 Sep 03; 7(40). PMID: 27588476 Free PMC article.
Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells. Blanca Homet Moreno, Jesse M Zaretsky, +11 authors, Antoni Ribas. less Cancer Immunol Res, 2016 Sep 04; 4(10). PMID: 27589875 Free PMC article.
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance. Maria Secrier, Xiaodun Li, +24 authors, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium. less Nat Genet, 2016 Sep 07; 48(10). PMID: 27595477 Free PMC article. Highly Cited.
Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes. Andreas Gloger, Danilo Ritz, Tim Fugmann, Dario Neri. Cancer Immunol Immunother, 2016 Oct 21; 65(11). PMID: 27600516 Free PMC article.
Addressing intra-tumoral heterogeneity and therapy resistance. Brad Rybinski, Kyuson Yun. Oncotarget, 2016 Sep 10; 7(44). PMID: 27608848 Free PMC article. Review.
Present Yourself! By MHC Class I and MHC Class II Molecules. Kenneth L Rock, Eric Reits, Jacques Neefjes. Trends Immunol, 2016 Sep 12; 37(11). PMID: 27614798 Free PMC article. Highly Cited. Review.
Calreticulin expression: Interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer. Gautier Stoll, Kristina Iribarren, +4 authors, Guido Kroemer. less Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622029 Free PMC article.
[Immunotherapy for HNSCC : Quo vadis?]. J Döscher, C-J Busch, P J Schuler, S Laban. HNO, 2016 Sep 15; 64(10). PMID: 27624904 Review.
High-content molecular profiling of T-cell therapy in oncology. Ruslan Novosiadly, Michael Kalos. Mol Ther Oncolytics, 2016 Sep 15; 3. PMID: 27626060 Free PMC article. Review.
Defining Glomerular Disease in Mechanistic Terms: Implementing an Integrative Biology Approach in Nephrology. Laura H Mariani, William F Pendergraft, Matthias Kretzler. Clin J Am Soc Nephrol, 2016 Sep 16; 11(11). PMID: 27630182 Free PMC article. Review.
Current management and future directions in metastatic pancreatic adenocarcinoma. Anna M Varghese, Maeve A Lowery, Kenneth H Yu, Eileen M O'Reilly. Cancer, 2016 Sep 21; 122(24). PMID: 27649047 Free PMC article. Review.
The genetics of uveal melanoma: current insights. Hildur Helgadottir, Veronica Höiom. Appl Clin Genet, 2016 Sep 24; 9. PMID: 27660484 Free PMC article. Review.
A retrospective analysis of High-Dose Interleukin-2 (HD IL-2) following Ipilimumab in metastatic melanoma. Elizabeth I Buchbinder, Anasuya Gunturi, +17 authors, David F McDermott. less J Immunother Cancer, 2016 Sep 24; 4. PMID: 27660706 Free PMC article.
Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies. Sander Bins, Geert A Cirkel, +19 authors, Martijn P Lolkema. less Oncologist, 2016 Sep 25; 22(1). PMID: 27662884 Free PMC article.
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration. Marcel Smid, F Germán Rodríguez-González, +44 authors, John W M Martens. less Nat Commun, 2016 Sep 27; 7. PMID: 27666519 Free PMC article.
Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy. Nadeem Riaz, Jonathan J Havel, +5 authors, Timothy A Chan. less Nat Genet, 2016 Oct 28; 48(11). PMID: 27668655 Free PMC article.
Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade. Douglas B Johnson, Garrett M Frampton, +24 authors, Christine M Lovly. less Cancer Immunol Res, 2016 Nov 03; 4(11). PMID: 27671167 Free PMC article. Highly Cited.
Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells. Elliott J Brea, Claire Y Oh, +15 authors, David A Scheinberg. less Cancer Immunol Res, 2016 Nov 03; 4(11). PMID: 27680026 Free PMC article.
The efficacy and safety of anti-PD-1/PD-L1 antibodies for treatment of advanced or refractory cancers: a meta-analysis. Tengfei Zhang, Jing Xie, +13 authors, Yi Zhang. less Oncotarget, 2016 Sep 30; 7(45). PMID: 27683031 Free PMC article.
The full blood count as a biomarker of outcome and toxicity in ipilimumab-treated cutaneous metastatic melanoma. Leila Khoja, Eshetu G Atenafu, +6 authors, Anthony M Joshua. less Cancer Med, 2016 Oct 30; 5(10). PMID: 27683208 Free PMC article.
Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy. Tanner M Johanns, Christopher A Miller, +10 authors, Gavin P Dunn. less Cancer Discov, 2016 Nov 04; 6(11). PMID: 27683556 Free PMC article. Highly Cited.
Mouse models in oncoimmunology. Laurence Zitvogel, Jonathan M Pitt, +2 authors, Romain Daillère, Mark J Smyth, Guido Kroemer. less Nat Rev Cancer, 2016 Nov 04; 16(12). PMID: 27687979 Highly Cited. Review.
Precision medicine from the renal cancer genome. Yasser Riazalhosseini, Mark Lathrop. Nat Rev Nephrol, 2016 Oct 04; 12(11). PMID: 27694978 Review.
Genomic Approaches to Understanding Response and Resistance to Immunotherapy. David A Braun, Kelly P Burke, Eliezer M Van Allen. Clin Cancer Res, 2016 Oct 05; 22(23). PMID: 27698000 Free PMC article. Review.
Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective. Guoli Chen, Zhaohai Yang, +2 authors, James R Eshleman, George J Netto, Ming-Tseh Lin. less Biomed Res Int, 2016 Oct 05; 2016. PMID: 27699178 Free PMC article. Review.
Claudin-low bladder tumors are immune infiltrated and actively immune suppressed. Jordan Kardos, Shengjie Chai, +8 authors, Benjamin G Vincent. less JCI Insight, 2016 Oct 05; 1(3). PMID: 27699256 Free PMC article. Highly Cited.
Resistance patterns to anti-PD-1 therapy in metastatic melanoma. Alpaslan Ozgun, Vernon K Sondak, Joseph Markowitz. Chin Clin Oncol, 2016 Oct 06; 5(6). PMID: 27701871 Free PMC article.
Recent advances in T-cell engineering for use in immunotherapy. Preeti Sharma, David M Kranz. F1000Res, 2016 Oct 06; 5. PMID: 27703664 Free PMC article. Review.
Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth. Anne Mobergslien, Qian Peng, Vlada Vasovic, Mouldy Sioud. Oncotarget, 2016 Oct 08; 7(46). PMID: 27713158 Free PMC article.
Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model. Anna E Kersh, Maiko Sasaki, +2 authors, Lee A Cooper, Haydn T Kissick, Brian P Pollack. less Front Pharmacol, 2016 Oct 13; 7. PMID: 27729860 Free PMC article. Review.
The promise of PD-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. PD-L1. Zhaohui Jin, Harry H Yoon. J Gastrointest Oncol, 2016 Oct 18; 7(5). PMID: 27747091 Free PMC article. Review.
Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma. Paul Zolkind, Gavin P Dunn, +3 authors, Ravindra Uppaluri. less Oral Oncol, 2016 Oct 19; 71. PMID: 27751760 Free PMC article. Review.
Mismatch repair deficiency may be common in ductal adenocarcinoma of the prostate. Michael T Schweizer, Heather H Cheng, +9 authors, Colin C Pritchard. less Oncotarget, 2016 Oct 21; 7(50). PMID: 27756888 Free PMC article.
Effective induction of cytotoxic T cells recognizing an epitope peptide derived from hypoxia-inducible protein 2 (HIG2) in patients with metastatic renal cell carcinoma. Wataru Obara, Takashi Karashima, +9 authors, Tomoaki Fujioka. less Cancer Immunol Immunother, 2016 Oct 21; 66(1). PMID: 27757561 Free PMC article.
Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death. Frederick J Kohlhapp, Erica J Huelsmann, +25 authors, Andrew Zloza. less Cell Rep, 2016 Oct 21; 17(4). PMID: 27760326 Free PMC article.
Combining Radiation Therapy with Immune Checkpoint Blockade for Central Nervous System Malignancies. Neil M D'Souza, Penny Fang, +3 authors, Jing Li. less Front Oncol, 2016 Oct 25; 6. PMID: 27774435 Free PMC article. Review.
Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set. Jason Roszik, Lauren E Haydu, +25 authors, Scott E Woodman. less BMC Med, 2016 Oct 26; 14(1). PMID: 27776519 Free PMC article. Highly Cited.
Lymphocyte activation gene 3 and coronary artery disease. Diana Golden, Antonina Kolmakova, +8 authors, Annabelle Rodriguez. less JCI Insight, 2016 Oct 26; 1(17). PMID: 27777974 Free PMC article.
The head and neck cancer immune landscape and its immunotherapeutic implications. Rajarsi Mandal, Yasin Şenbabaoğlu, +8 authors, Luc Gt Morris. less JCI Insight, 2016 Oct 26; 1(17). PMID: 27777979 Free PMC article. Highly Cited.
Aptamers: A New Technological Platform in Cancer Immunotherapy. Fernando Pastor. Pharmaceuticals (Basel), 2016 Oct 27; 9(4). PMID: 27783034 Free PMC article. Review.
High-Accuracy HLA Type Inference from Whole-Genome Sequencing Data Using Population Reference Graphs. Alexander T Dilthey, Pierre-Antoine Gourraud, +3 authors, Gil McVean. less PLoS Comput Biol, 2016 Oct 30; 12(10). PMID: 27792722 Free PMC article.
Recent advances in understanding antitumor immunity. Rodrigo Ramella Munhoz, Michael Andrew Postow. F1000Res, 2016 Nov 03; 5. PMID: 27803807 Free PMC article. Review.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. Vassiliki A Boussiotis. N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234 Free PMC article. Highly Cited. Review.
Successful Treatment of a Patient with Glioblastoma and a Germline POLE Mutation: Where Next? Alexandra Snyder, Jedd D Wolchok. Cancer Discov, 2016 Nov 04; 6(11). PMID: 27807100 Free PMC article.
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors. Wei Xue, Victoria A Brentville, +4 authors, Lindy G Durrant. less Oncotarget, 2016 Nov 09; 7(50). PMID: 27825115 Free PMC article.
Gene-expression profiling to predict responsiveness to immunotherapy. N B Jamieson, A V Maker. Cancer Gene Ther, 2016 Nov 12; 24(3). PMID: 27834354 Free PMC article. Review.
Making urothelial carcinomas less immune to immunotherapy. Jorge D Ramos, Evan Y Yu. Urol Oncol, 2016 Nov 12; 34(12). PMID: 27836245 Free PMC article. Review.
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers. Randy F Sweis, Matthew D Galsky. Urol Oncol, 2016 Nov 12; 34(12). PMID: 27836246 Free PMC article. Review.
Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma. Stefani Spranger, Jason J Luke, +6 authors, Thomas F Gajewski. less Proc Natl Acad Sci U S A, 2016 Nov 12; 113(48). PMID: 27837020 Free PMC article. Highly Cited.
Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors. Ludmila Danilova, Hao Wang, +9 authors, Janis M Taube. less Proc Natl Acad Sci U S A, 2016 Nov 12; 113(48). PMID: 27837027 Free PMC article. Highly Cited.
Immune checkpoint blockade in small cell lung cancer: is there a light at the end of the tunnel? Luca Paglialunga, Zena Salih, Biagio Ricciuti, Raffaele Califano. ESMO Open, 2016 Nov 16; 1(4). PMID: 27843619 Free PMC article. Review.
Recent advances in the biology of human circulating tumour cells and metastasis. Sofia Gkountela, Barbara Szczerba, Cinzia Donato, Nicola Aceto. ESMO Open, 2016 Nov 16; 1(4). PMID: 27843628 Free PMC article. Review.
Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures. Yasin Şenbabaoğlu, Ron S Gejman, +26 authors, A Ari Hakimi. less Genome Biol, 2016 Nov 20; 17(1). PMID: 27855702 Free PMC article. Highly Cited.
The Role of Next-Generation Sequencing in Enabling Personalized Oncology Therapy. C A Cummings, E Peters, +2 authors, L Lacroix, F Andre, M R Lackner. less Clin Transl Sci, 2016 Nov 20; 9(6). PMID: 27860319 Free PMC article.
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry. Michal Bassani-Sternberg, Eva Bräunlein, +16 authors, Angela M Krackhardt. less Nat Commun, 2016 Nov 22; 7. PMID: 27869121 Free PMC article. Highly Cited.
Combinational Immunotherapy with Allo-DRibble Vaccines and Anti-OX40 Co-Stimulation Leads to Generation of Cross-Reactive Effector T Cells and Tumor Regression. Guangjie Yu, Yuhuan Li, +6 authors, Hong-Ming Hu. less Sci Rep, 2016 Nov 23; 6. PMID: 27874054 Free PMC article.
Comparison of exome-based HLA class I genotyping tools: identification of platform-specific genotyping errors. Kazuma Kiyotani, Tu H Mai, Yusuke Nakamura. J Hum Genet, 2016 Nov 25; 62(3). PMID: 27881843 Free PMC article.
Advances in Cancer Immunotherapy in Solid Tumors. Smitha Menon, Sarah Shin, Grace Dy. Cancers (Basel), 2016 Nov 26; 8(12). PMID: 27886124 Free PMC article. Highly Cited. Review.
Validation of biomarkers to predict response to immunotherapy in cancer: Volume I - pre-analytical and analytical validation. Giuseppe V Masucci, Alessandra Cesano, +10 authors, Magdalena Thurin. less J Immunother Cancer, 2016 Nov 30; 4. PMID: 27895917 Free PMC article. Highly Cited. Review.
The role of immune checkpoint inhibition in the treatment of ovarian cancer. Stéphanie L Gaillard, Angeles A Secord, Bradley Monk. Gynecol Oncol Res Pract, 2016 Dec 03; 3. PMID: 27904752 Free PMC article. Review.
Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting. Julie E Bauman, Ezra Cohen, +17 authors, Shakun Malik. less Cancer, 2016 Dec 03; 123(7). PMID: 27906454 Free PMC article.
Robust detection of immune transcripts in FFPE samples using targeted RNA sequencing. Benjamin E Paluch, Sean T Glenn, +14 authors, Carl D Morrison. less Oncotarget, 2016 Dec 03; 8(2). PMID: 27911273 Free PMC article.
Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine. Gerald Goh, Ramona Schmid, +16 authors, Charles Swanton. less PLoS Med, 2016 Dec 07; 13(12). PMID: 27923043 Free PMC article.
Predictive biomarkers for checkpoint inhibitor-based immunotherapy. Geoffrey T Gibney, Louis M Weiner, Michael B Atkins. Lancet Oncol, 2016 Dec 08; 17(12). PMID: 27924752 Free PMC article. Highly Cited. Review.
Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade. Tavi Nathanson, Arun Ahuja, +8 authors, Jeff Hammerbacher. less Cancer Immunol Res, 2016 Dec 14; 5(1). PMID: 27956380 Free PMC article.
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer. Eric Tran, Paul F Robbins, +9 authors, Steven A Rosenberg. less N Engl J Med, 2016 Dec 14; 375(23). PMID: 27959684 Free PMC article. Highly Cited.
Immunotherapy in the Precision Medicine Era: Melanoma and Beyond. Mack Y Su, David E Fisher. PLoS Med, 2016 Dec 14; 13(12). PMID: 27959922 Free PMC article.
Predictors of Chemosensitivity in Triple Negative Breast Cancer: An Integrated Genomic Analysis. Tingting Jiang, Weiwei Shi, +8 authors, Christos Hatzis. less PLoS Med, 2016 Dec 14; 13(12). PMID: 27959926 Free PMC article.
Immuno-Oncology: The Third Paradigm in Early Drug Development. Juan Martin-Liberal, Cinta Hierro, Maria Ochoa de Olza, Jordi Rodon. Target Oncol, 2016 Dec 21; 12(2). PMID: 27995439
Immunotherapy of Malignant Tumors in the Brain: How Different from Other Sites? Valérie Dutoit, Denis Migliorini, Pierre-Yves Dietrich, Paul R Walker. Front Oncol, 2016 Dec 23; 6. PMID: 28003994 Free PMC article. Review.
Dendritic cell-based immunotherapy. Rachel L Sabado, Sreekumar Balan, Nina Bhardwaj. Cell Res, 2016 Dec 28; 27(1). PMID: 28025976 Free PMC article. Highly Cited. Review.
Immune targets and neoantigens for cancer immunotherapy and precision medicine. Rong-Fu Wang, Helen Y Wang. Cell Res, 2016 Dec 28; 27(1). PMID: 28025978 Free PMC article. Highly Cited. Review.
Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer. Valsamo Anagnostou, Kellie N Smith, +26 authors, Victor E Velculescu. less Cancer Discov, 2016 Dec 30; 7(3). PMID: 28031159 Free PMC article. Highly Cited.
Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire. David Y Oh, Jason Cham, +5 authors, Lawrence Fong. less Cancer Res, 2016 Dec 30; 77(6). PMID: 28031229 Free PMC article.
Challenges and opportunities for checkpoint blockade in T-cell lymphoproliferative disorders. Tycel Phillips, Sumana Devata, Ryan A Wilcox. J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031823 Free PMC article. Review.
Checkpoint Inhibitors for Advanced Bladder Cancer. Edward M Messing. Bladder Cancer, 2016 Dec 31; 2(4). PMID: 28035330 Free PMC article.
How "precise" is precision medicine in hematology? Carlo Gambacorti-Passerini, Rocco Piazza. Haematologica, 2017 Jan 04; 102(1). PMID: 28040787 Free PMC article.
Identification of coding and non-coding mutational hotspots in cancer genomes. Scott W Piraino, Simon J Furney. BMC Genomics, 2017 Jan 07; 18(1). PMID: 28056774 Free PMC article.
Near future of tumor immunology: Anticipating resistance mechanisms to immunotherapies, a big challenge for clinical trials. João Paulo Portela Catani, Rachel P Riechelmann, Sandy Adjemian, Bryan E Strauss. Hum Vaccin Immunother, 2017 Jan 07; 13(5). PMID: 28059608 Free PMC article.
The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment. Shona A Hendry, Rae H Farnsworth, +3 authors, Stephen B Fox. less Front Immunol, 2017 Jan 10; 7. PMID: 28066431 Free PMC article. Highly Cited. Review.
Identification of immunoglobulin V(D)J recombinations in solid tumor specimen exome files: Evidence for high level B-cell infiltrates in breast cancer. Wei Lue Tong, Yaping N Tu, +2 authors, Mohammad D Samy, Wade J Sexton, George Blanck. less Hum Vaccin Immunother, 2017 Jan 14; 13(3). PMID: 28085544 Free PMC article.
A phase 2 study of alisertib (MLN8237) in recurrent or persistent uterine leiomyosarcoma: An NRG Oncology/Gynecologic Oncology Group study 0231D. David M Hyman, Michael W Sill, +9 authors, Martee L Hensley. less Gynecol Oncol, 2017 Jan 18; 144(1). PMID: 28094040 Free PMC article.
Genomic analysis and clinical management of adolescent cutaneous melanoma. Roy Rabbie, Mamunur Rashid, +13 authors, David J Adams. less Pigment Cell Melanoma Res, 2017 Jan 18; 30(3). PMID: 28097802 Free PMC article.
Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira Mellman. Nature, 2017 Jan 20; 541(7637). PMID: 28102259 Highly Cited. Review.
T-cell receptor-engineered T cells for cancer treatment: current status and future directions. Yu Ping, Chaojun Liu, Yi Zhang. Protein Cell, 2017 Jan 22; 9(3). PMID: 28108950 Free PMC article. Highly Cited. Review.
Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy? Giuseppe Palmieri, Maria Colombino, +3 authors, Paolo A Ascierto. less J Transl Med, 2017 Jan 23; 15(1). PMID: 28109293 Free PMC article.
Radiotherapy and Immune Checkpoint Blockade for Melanoma: A Promising Combinatorial Strategy in Need of Further Investigation. Freddy E Escorcia, Michael A Postow, Christopher A Barker. Cancer J, 2017 Jan 24; 23(1). PMID: 28114252 Free PMC article. Review.
It's a long way to the top (if you want to personalize immunotherapy). Sarah Haebe, Oliver Weigert. J Immunother Cancer, 2017 Jan 25; 5. PMID: 28116089 Free PMC article.
Strong Correlation of Indoleamine 2,3-Dioxygenase 1 Expression with Basal-Like Phenotype and Increased Lymphocytic Infiltration in Triple-Negative Breast Cancer. Sewha Kim, Sanghui Park, +3 authors, Sun Hee Sung. less J Cancer, 2017 Jan 27; 8(1). PMID: 28123606 Free PMC article.
Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients. Yumi Nonomura, Atsushi Otsuka, +14 authors, Kenji Kabashima. less Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123885 Free PMC article.
Clinical implication of tumor-associated and immunological parameters in melanoma patients treated with ipilimumab. V Damuzzo, S Solito, +6 authors, S Mandruzzato. less Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123888 Free PMC article.
MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy. Simon Laban, Gregor Giebel, +18 authors, Sven Perner. less Oncotarget, 2017 Feb 02; 8(9). PMID: 28146422 Free PMC article.
A meta-analysis of HLA peptidome composition in different hematological entities: entity-specific dividing lines and "pan-leukemia" antigens. Linus Backert, Daniel Johannes Kowalewski, +14 authors, Juliane Sarah Walz. less Oncotarget, 2017 Feb 06; 8(27). PMID: 28159928 Free PMC article.
Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients. Kilian Wistuba-Hamprecht, Alexander Martens, +18 authors, Benjamin Weide. less Eur J Cancer, 2017 Feb 09; 73. PMID: 28167454 Free PMC article.
Next steps in immuno-oncology: enhancing antitumor effects through appropriate patient selection and rationally designed combination strategies. A K S Salama, S J Moschos. Ann Oncol, 2017 Feb 09; 28(1). PMID: 28177433 Free PMC article. Review.
Comprehensive analysis of PD-L1 expression in glioblastoma multiforme. Dieter Henrik Heiland, Gerrit Haaker, +9 authors, Oliver Schnell. less Oncotarget, 2017 Feb 09; 8(26). PMID: 28178682 Free PMC article.
Applications of Immunogenomics to Cancer. X Shirley Liu, Elaine R Mardis. Cell, 2017 Feb 12; 168(4). PMID: 28187283 Free PMC article. Highly Cited. Review.
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy. Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas. Cell, 2017 Feb 12; 168(4). PMID: 28187290 Free PMC article. Highly Cited. Review.
Transcriptional Mechanisms of Resistance to Anti-PD-1 Therapy. Maria L Ascierto, Alvin Makohon-Moore, +18 authors, Suzanne L Topalian. less Clin Cancer Res, 2017 Feb 15; 23(12). PMID: 28193624 Free PMC article.
Analysis of the prognostic role of an immune checkpoint score in resected non-small cell lung cancer patients. Marta Usó, Eloísa Jantus-Lewintre, +6 authors, Rafael Sirera. less Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197383 Free PMC article.
'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations. Eric Tran, Paul F Robbins, Steven A Rosenberg. Nat Immunol, 2017 Feb 16; 18(3). PMID: 28198830 Free PMC article. Highly Cited. Review.
Targeting PD-1/PD-L1 in lung cancer: current perspectives. María González-Cao, Niki Karachaliou, +6 authors, Rafael Rosell. less Lung Cancer (Auckl), 2015 Jul 31; 6. PMID: 28210151 Free PMC article. Review.
Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma. Suzanne George, Diana Miao, +13 authors, Eliezer M Van Allen. less Immunity, 2017 Feb 24; 46(2). PMID: 28228279 Free PMC article. Highly Cited.
Targeting neoantigens to augment antitumour immunity. Mark Yarchoan, Burles A Johnson, +2 authors, Eric R Lutz, Daniel A Laheru, Elizabeth M Jaffee. less Nat Rev Cancer, 2017 Feb 25; 17(4). PMID: 28233802 Free PMC article. Highly Cited. Review.
A Novel DNA Vaccine Platform Enhances Neo-antigen-like T Cell Responses against WT1 to Break Tolerance and Induce Anti-tumor Immunity. Jewell N Walters, Bernadette Ferraro, +8 authors, David B Weiner. less Mol Ther, 2017 Feb 27; 25(4). PMID: 28237837 Free PMC article.
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Whijae Roh, Pei-Ling Chen, +37 authors, P Andrew Futreal. less Sci Transl Med, 2017 Mar 03; 9(379). PMID: 28251903 Free PMC article. Highly Cited.
Tissue-specific tumorigenesis: context matters. Günter Schneider, Marc Schmidt-Supprian, Roland Rad, Dieter Saur. Nat Rev Cancer, 2017 Mar 04; 17(4). PMID: 28256574 Free PMC article. Highly Cited. Review.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma. Liliana E Lucca, David A Hafler. Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258696 Free PMC article. Review.
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance. Weiwei Wang, Lijun Zhang, +5 authors, Shaojia Wang. less Oncol Rep, 2017 Mar 06; 37(4). PMID: 28260069 Free PMC article.
Debugging the Black Box. James C Yang. Cancer Discov, 2017 Mar 08; 7(3). PMID: 28264866 Free PMC article.
Manipulation of Innate and Adaptive Immunity through Cancer Vaccines. Elias J Sayour, Duane A Mitchell. J Immunol Res, 2017 Mar 08; 2017. PMID: 28265580 Free PMC article. Review.
Precision medicine driven by cancer systems biology. Fabian V Filipp. Cancer Metastasis Rev, 2017 Mar 08; 36(1). PMID: 28265786 Free PMC article.
ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment. Chi-Fen Chen, Rolando Ruiz-Vega, +9 authors, Anand K Ganesan. less Cell Rep, 2017 Mar 09; 18(10). PMID: 28273450 Free PMC article.
Current companion diagnostics in advanced colorectal cancer; getting a bigger and better piece of the pie. Jonathan M Loree, Scott Kopetz, Kanwal P S Raghav. J Gastrointest Oncol, 2017 Mar 11; 8(1). PMID: 28280626 Free PMC article. Review.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma. Manohan Sinnadurai, Kerrie L McDonald. J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764 Review.
Immune Checkpoint Inhibitors in Gliomas. Aaron C Tan, Amy B Heimberger, Mustafa Khasraw. Curr Oncol Rep, 2017 Mar 18; 19(4). PMID: 28303490 Review.
The Five Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy. Suneetha Amara, Venkataswarup Tiriveedhi. Int J Mol Sci, 2017 Mar 18; 18(3). PMID: 28304339 Free PMC article. Review.
Immunotherapy: a new treatment paradigm in bladder cancer. Nicole N Davarpanah, Akira Yuno, Jane B Trepel, Andrea B Apolo. Curr Opin Oncol, 2017 Mar 18; 29(3). PMID: 28306559 Free PMC article.
Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia. Stacy A Malaker, Sarah A Penny, +7 authors, Mark Cobbold. less Cancer Immunol Res, 2017 Mar 21; 5(5). PMID: 28314751 Free PMC article.
Evolution of MHC-based technologies used for detection of antigen-responsive T cells. Amalie Kai Bentzen, Sine Reker Hadrup. Cancer Immunol Immunother, 2017 Mar 21; 66(5). PMID: 28314956 Free PMC article. Review.
Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines. Jason Lohmueller, Olivera J Finn. Pharmacol Ther, 2017 Mar 23; 178. PMID: 28322974 Free PMC article. Review.
Systematic evaluation of immune regulation and modulation. David F Stroncek, Lisa H Butterfield, +12 authors, Barbara Seliger. less J Immunother Cancer, 2017 Mar 24; 5. PMID: 28331613 Free PMC article. Review.
MAGE-A Antigens and Cancer Immunotherapy. Paul Zajac, Elke Schultz-Thater, +5 authors, Giulio C Spagnoli. less Front Med (Lausanne), 2017 Mar 25; 4. PMID: 28337438 Free PMC article.
Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis. Wouter Hendrickx, Ines Simeone, +14 authors, Davide Bedognetti. less Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344865 Free PMC article. Highly Cited.
Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition. Florine A Eggink, Inge C Van Gool, +11 authors, Tjalling Bosse. less Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344870 Free PMC article.
Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma. Kazuma Kiyotani, Jae-Hyun Park, +5 authors, Wickii T Vigneswaran. less Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344893 Free PMC article.
Pharmacogenomics of off-target adverse drug reactions. Sarah L Garon, Rebecca K Pavlos, +3 authors, Elizabeth J Phillips. less Br J Clin Pharmacol, 2017 Mar 28; 83(9). PMID: 28345177 Free PMC article. Review.
Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers. Erik S Knudsen, Paris Vail, +9 authors, Agnieszka K Witkiewicz. less Clin Cancer Res, 2017 Mar 30; 23(15). PMID: 28348045 Free PMC article. Highly Cited.
Molecular genetic and immunotherapeutic targets in metastatic melanoma. C Melis, A Rogiers, O Bechter, Joost J van den Oord. Virchows Arch, 2017 Mar 31; 471(2). PMID: 28357489 Review.
Ultrasensitive detection of TCR hypervariable-region sequences in solid-tissue RNA-seq data. Bo Li, Taiwen Li, +4 authors, X Shirley Liu. less Nat Genet, 2017 Mar 31; 49(4). PMID: 28358132 Free PMC article.
The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation. Florian Wolff, Michael Leisch, +2 authors, Richard Greil, Angela Risch, Lisa Pleyer. less Cell Commun Signal, 2017 Apr 01; 15(1). PMID: 28359286 Free PMC article. Review.
Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ. Ruth J Davis, Ellen C Moore, +6 authors, Clint Allen. less Cancer Res, 2017 Apr 02; 77(10). PMID: 28364000 Free PMC article. Highly Cited.
Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy. Tiffany R Hodges, Martina Ott, +9 authors, Amy B Heimberger. less Neuro Oncol, 2017 Apr 04; 19(8). PMID: 28371827 Free PMC article. Highly Cited.
Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma. Winnie S Liang, William Hendricks, +23 authors, Jeffrey Trent. less Genome Res, 2017 Apr 05; 27(4). PMID: 28373299 Free PMC article.
Targeted Therapies for Melanoma Brain Metastases. Anna S Berghoff, Matthias Preusser. Curr Treat Options Neurol, 2017 Apr 05; 19(4). PMID: 28374234 Free PMC article. Review.
Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment. James L Gulley, Ravi A Madan, +4 authors, Charles G Drake. less J Natl Cancer Inst, 2017 Apr 05; 109(4). PMID: 28376158 Free PMC article. Highly Cited. Review.
Cancer immunotherapies targeting the PD-1 signaling pathway. Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo. J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884 Free PMC article. Highly Cited. Review.
UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Jake Wang, Curtis J Perry, +6 authors, Marcus Bosenberg. less Pigment Cell Melanoma Res, 2017 Apr 06; 30(4). PMID: 28379630 Free PMC article. Highly Cited.
Tumor Vaccines for Malignant Gliomas. Visish M Srinivasan, Sherise D Ferguson, +3 authors, Amy B Heimberger. less Neurotherapeutics, 2017 Apr 09; 14(2). PMID: 28389997 Free PMC article. Review.
Emerging role of mutations in epigenetic regulators including MLL2 derived from The Cancer Genome Atlas for cervical cancer. Xia Li. BMC Cancer, 2017 Apr 10; 17(1). PMID: 28390392 Free PMC article.
Clinical Features of Acquired Resistance to Anti-PD-1 Therapy in Advanced Melanoma. Daniel Y Wang, Zeynep Eroglu, +11 authors, Elizabeth I Buchbinder. less Cancer Immunol Res, 2017 Apr 12; 5(5). PMID: 28396509 Free PMC article.
Indicators of responsiveness to immune checkpoint inhibitors. Bradley D Shields, Fade Mahmoud, +10 authors, Alan J Tackett. less Sci Rep, 2017 Apr 13; 7(1). PMID: 28400597 Free PMC article.
Resistance to immunotherapy: clouds in a bright sky. Gérard Milano. Invest New Drugs, 2017 Apr 13; 35(5). PMID: 28401366 Review.
HLA class I-restricted MYD88 L265P-derived peptides as specific targets for lymphoma immunotherapy. Annika Nelde, Juliane Sarah Walz, +14 authors, Alexander N R Weber. less Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405493 Free PMC article.
Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody. Andres Lopez-Albaitero, Hong Xu, +8 authors, Nai-Kong V Cheung. less Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405494 Free PMC article.
PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma. Jan Budczies, Gunhild Mechtersheimer, +17 authors, Albrecht Stenzinger. less Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405504 Free PMC article.
Applied Cancer Immunogenomics: Leveraging Neoantigen Discovery in Glioblastoma. Tanner M Johanns, Gavin P Dunn. Cancer J, 2017 Apr 15; 23(2). PMID: 28410300 Free PMC article. Review.
Antigen Discovery and Therapeutic Targeting in Hematologic Malignancies. David A Braun, Catherine J Wu. Cancer J, 2017 Apr 15; 23(2). PMID: 28410299 Free PMC article. Review.
Dendritic Cell Strategies for Eliciting Mutation-Derived Tumor Antigen Responses in Patients. Sreekumar Balan, John Finnigan, Nina Bhardwaj. Cancer J, 2017 Apr 15; 23(2). PMID: 28410301 Free PMC article. Review.
Immune Checkpoint Inhibitors for Brain Metastases. Aaron C Tan, Amy B Heimberger, +2 authors, Alexander M Menzies, Nick Pavlakis, Mustafa Khasraw. less Curr Oncol Rep, 2017 Apr 19; 19(6). PMID: 28417311 Review.
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Zachary R Chalmers, Caitlin F Connelly, +21 authors, Garrett M Frampton. less Genome Med, 2017 Apr 20; 9(1). PMID: 28420421 Free PMC article. Highly Cited.
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel. Melita Irving, Romain Vuillefroy de Silly, +2 authors, Kirsten Scholten, Nahzli Dilek, George Coukos. less Front Immunol, 2017 Apr 20; 8. PMID: 28421069 Free PMC article. Review.
[The pathology of adverse events with immune checkpoint inhibitors]. V H Koelzer, K Glatz, +7 authors, K D Mertz. less Pathologe, 2017 Apr 20; 38(3). PMID: 28421272 Review.
Multi-omics study revealing the complexity and spatial heterogeneity of tumor-infiltrating lymphocytes in primary liver carcinoma. Lijun Shi, Yang Zhang, +6 authors, Shujun Cheng. less Oncotarget, 2017 Apr 20; 8(21). PMID: 28422742 Free PMC article.
HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model. Barbara Schrörs, Silke Lübcke, +8 authors, Thomas Wölfel. less Oncotarget, 2017 Apr 21; 8(17). PMID: 28423700 Free PMC article.
Immunotherapy and targeted therapy in brain metastases: emerging options in precision medicine. Tyler Lazaro, Priscilla K Brastianos. CNS Oncol, 2017 Apr 21; 6(2). PMID: 28425754 Free PMC article. Review.
The use of immunotherapy in the treatment of melanoma. Tala Achkar, Ahmad A Tarhini. J Hematol Oncol, 2017 Apr 25; 10(1). PMID: 28434398 Free PMC article. Review.
Spotlight on nivolumab in the treatment of renal cell carcinoma: design, development, and place in therapy. Vyshak Alva Venur, Monika Joshi, Kenneth G Nepple, Yousef Zakharia. Drug Des Devel Ther, 2017 Apr 27; 11. PMID: 28442891 Free PMC article. Review.
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Kole T Roybal, Wendell A Lim. Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446063 Free PMC article. Review.
Landscape of Combination Immunotherapy and Targeted Therapy to Improve Cancer Management. Leandro M Colli, Mitchell J Machiela, +5 authors, Stephen J Chanock. less Cancer Res, 2017 Apr 28; 77(13). PMID: 28446466 Free PMC article.
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients. Alice O Kamphorst, Rathi N Pillai, +16 authors, Suresh S Ramalingam. less Proc Natl Acad Sci U S A, 2017 Apr 28; 114(19). PMID: 28446615 Free PMC article. Highly Cited.
Association of CTLA-4 Gene Variants with Response to Therapy and Long-term Survival in Metastatic Melanoma Patients Treated with Ipilimumab: An Italian Melanoma Intergroup Study. Paola Queirolo, Beatrice Dozin, +28 authors, Maria Pia Pistillo. less Front Immunol, 2017 Apr 28; 8. PMID: 28446908 Free PMC article.
Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal. P A Ott, S A Piha-Paul, +13 authors, J Bennouna. less Ann Oncol, 2017 Apr 30; 28(5). PMID: 28453692 Free PMC article. Highly Cited.
T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas. Seth M Pollack, Qianchuan He, +21 authors, Robin L Jones. less Cancer, 2017 May 04; 123(17). PMID: 28463396 Free PMC article. Highly Cited.
Human Tumor Antigens Yesterday, Today, and Tomorrow. Olivera J Finn. Cancer Immunol Res, 2017 May 04; 5(5). PMID: 28465452 Free PMC article. Review.
Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model. Kyoung-Jin Kim, Ji-Hye Kim, +3 authors, Jinsil Seong. less Oncotarget, 2017 May 04; 8(25). PMID: 28465485 Free PMC article.
Academic, Foundation, and Industry Collaboration in Finding New Therapies. Bonnie W Ramsey, Gerald T Nepom, Sagar Lonial. N Engl J Med, 2017 May 04; 376(18). PMID: 28467868 Free PMC article. Review.
Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study. Jung-Min Lee, Ashley Cimino-Mathews, +16 authors, Elise C Kohn. less J Clin Oncol, 2017 May 05; 35(19). PMID: 28471727 Free PMC article. Highly Cited.
Current status of chimeric antigen receptor engineered T cell-based and immune checkpoint blockade-based cancer immunotherapies. Upendra P Hegde, Bijay Mukherji. Cancer Immunol Immunother, 2017 May 13; 66(9). PMID: 28497159 Free PMC article. Review.
Phase I clinical trial of cell division associated 1 (CDCA1) peptide vaccination for castration resistant prostate cancer. Wataru Obara, Fuminori Sato, +8 authors, Tomoaki Fujioka. less Cancer Sci, 2017 May 13; 108(7). PMID: 28498618 Free PMC article.
Immunotherapy for the Treatment of Uveal Melanoma: Current Status and Emerging Therapies. Kimberly M Komatsubara, Richard D Carvajal. Curr Oncol Rep, 2017 May 17; 19(7). PMID: 28508938 Review.
Mechanisms of Immune Tolerance in Leukemia and Lymphoma. Emily K Curran, James Godfrey, Justin Kline. Trends Immunol, 2017 May 18; 38(7). PMID: 28511816 Free PMC article. Review.
Genetic load makes cancer cells more sensitive to common drugs: evidence from Cancer Cell Line Encyclopedia. Ana B Pavel, Kirill S Korolev. Sci Rep, 2017 May 18; 7(1). PMID: 28512298 Free PMC article.
Chromatin states define tumour-specific T cell dysfunction and reprogramming. Mary Philip, Lauren Fairchild, +11 authors, Andrea Schietinger. less Nature, 2017 May 18; 545(7655). PMID: 28514453 Free PMC article. Highly Cited.
Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy. Sacha Gnjatic, Vincenzo Bronte, +13 authors, Lisa H Butterfield. less J Immunother Cancer, 2017 May 19; 5. PMID: 28515944 Free PMC article. Highly Cited. Review.
Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1. Elizabeth A McNiel, Philip N Tsichlis. Signal Transduct Target Ther, 2017 May 19; 2. PMID: 28515962 Free PMC article.
Hallmarks of response to immune checkpoint blockade. Alexandria P Cogdill, Miles C Andrews, Jennifer A Wargo. Br J Cancer, 2017 May 20; 117(1). PMID: 28524159 Free PMC article. Highly Cited. Review.
Immunogenomics: using genomics to personalize cancer immunotherapy. Rance C Siniard, Shuko Harada. Virchows Arch, 2017 May 22; 471(2). PMID: 28528510 Review.
Clinical experiences of combining immunotherapy and radiation therapy in non-small cell lung cancer: lessons from melanoma. Anusha Kalbasi, Ramesh Rengan. Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529899 Free PMC article. Review.
HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses. Vitaly Kochin, Takayuki Kanaseki, +11 authors, Toshihiko Torigoe. less Oncoimmunology, 2017 May 24; 6(4). PMID: 28533942 Free PMC article.
The Damaging Effect of Passenger Mutations on Cancer Progression. Christopher D McFarland, Julia A Yaglom, +4 authors, Leonid A Mirny. less Cancer Res, 2017 May 26; 77(18). PMID: 28536279 Free PMC article.
Immune signature of metastatic breast cancer: Identifying predictive markers of immunotherapy response. Ji-Yeon Kim, Eunjin Lee, +5 authors, Yeon Hee Park. less Oncotarget, 2017 May 26; 8(29). PMID: 28537889 Free PMC article.
Therapeutic T cell engineering. Michel Sadelain, Isabelle Rivière, Stanley Riddell. Nature, 2017 May 26; 545(7655). PMID: 28541315 Free PMC article. Highly Cited. Review.
Immune and molecular correlates in melanoma treated with immune checkpoint blockade. Elizabeth H Byrne, David E Fisher. Cancer, 2017 May 26; 123(S11). PMID: 28543699 Free PMC article. Review.
Interaction of molecular alterations with immune response in melanoma. Robert A Szczepaniak Sloane, Vancheswaran Gopalakrishnan, +3 authors, Jennifer A Wargo. less Cancer, 2017 May 26; 123(S11). PMID: 28543700 Free PMC article. Review.
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis. Alexandra Snyder, Tavi Nathanson, +18 authors, Dean F Bajorin. less PLoS Med, 2017 May 30; 14(5). PMID: 28552987 Free PMC article. Highly Cited.
The Transcriptional Landscape of p53 Signalling Pathway. Chizu Tanikawa, Yao-Zhong Zhang, +10 authors, Koichi Matsuda. less EBioMedicine, 2017 Jun 01; 20. PMID: 28558959 Free PMC article.
Immunotherapy in head and neck cancer: aiming at EXTREME precision. Petr Szturz, Jan B Vermorken. BMC Med, 2017 Jun 03; 15(1). PMID: 28571578 Free PMC article.
Immunotherapy for Breast Cancer: What Are We Missing? Robert H Vonderheide, Susan M Domchek, Amy S Clark. Clin Cancer Res, 2017 Jun 03; 23(11). PMID: 28572258 Free PMC article. Highly Cited.
A molecular portrait of microsatellite instability across multiple cancers. Isidro Cortes-Ciriano, Sejoon Lee, +2 authors, Woong-Yang Park, Tae-Min Kim, Peter J Park. less Nat Commun, 2017 Jun 07; 8. PMID: 28585546 Free PMC article. Highly Cited.
Systematic genomic and translational efficiency studies of uveal melanoma. Chelsea Place Johnson, Ivana K Kim, +19 authors, Scott E Woodman. less PLoS One, 2017 Jun 09; 12(6). PMID: 28594900 Free PMC article.
Identifying "super responders" in pulmonary arterial hypertension. Stephen J Halliday, Anna R Hemnes. Pulm Circ, 2017 Jun 10; 7(2). PMID: 28597766 Free PMC article.
New insights into the role of EMT in tumor immune escape. Stéphane Terry, Pierre Savagner, +4 authors, Salem Chouaib. less Mol Oncol, 2017 Jun 15; 11(7). PMID: 28614624 Free PMC article. Highly Cited. Review.
Phase II Study of Adjuvant Immunotherapy with the CSF-470 Vaccine Plus Bacillus Calmette-Guerin Plus Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor vs Medium-Dose Interferon Alpha 2B in Stages IIB, IIC, and III Cutaneous Melanoma Patients: A Single Institution, Randomized Study. José Mordoh, María Betina Pampena, +11 authors, María Marcela Barrio. less Front Immunol, 2017 Jun 18; 8. PMID: 28620382 Free PMC article.
Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies. Jeong A Park, Nai-Kong V Cheung. Cancer Treat Rev, 2017 Jun 18; 58. PMID: 28622628 Free PMC article. Review.
DNA Damage and Repair Biomarkers of Immunotherapy Response. Kent W Mouw, Michael S Goldberg, Panagiotis A Konstantinopoulos, Alan D D'Andrea. Cancer Discov, 2017 Jun 21; 7(7). PMID: 28630051 Free PMC article. Highly Cited. Review.
Systems immunology: just getting started. Mark M Davis, Cristina M Tato, David Furman. Nat Immunol, 2017 Jun 21; 18(7). PMID: 28632713 Free PMC article. Highly Cited. Review.
Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors. Keisuke Fujii, Yoshihiro Miyahara, +10 authors, Hiroshi Shiku. less Oncoimmunology, 2017 Jun 24; 6(5). PMID: 28638727 Free PMC article.
Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity. Maher G Nawaf, Maria H Ulvmar, +7 authors, Peter J L Lane. less J Immunol, 2017 Jun 25; 199(3). PMID: 28646041 Free PMC article.
Immunotherapy biomarkers 2016: overcoming the barriers. James L Gulley, Jay A Berzofsky, +18 authors, Lisa H Butterfield. less J Immunother Cancer, 2017 Jun 28; 5(1). PMID: 28653584 Free PMC article.
Monitoring immune-checkpoint blockade: response evaluation and biomarker development. Mizuki Nishino, Nikhil H Ramaiya, Hiroto Hatabu, F Stephen Hodi. Nat Rev Clin Oncol, 2017 Jun 28; 14(11). PMID: 28653677 Free PMC article. Highly Cited. Review.
IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Christopher J Nirschl, Mayte Suárez-Fariñas, +26 authors, Niroshana Anandasabapathy. less Cell, 2017 Jul 01; 170(1). PMID: 28666115 Free PMC article. Highly Cited.
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Ugur Sahin, Evelyna Derhovanessian, +47 authors, Özlem Türeci. less Nature, 2017 Jul 06; 547(7662). PMID: 28678784 Highly Cited.
Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression. Julian P Layer, Marie T Kronmüller, +13 authors, Michael Hölzel. less Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680756 Free PMC article.
Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: A pilot study. Yong Qin, Mariana Petaccia de Macedo, +24 authors, Sapna P Patel. less Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680759 Free PMC article.
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy. Stephanie R Barbari, Polina V Shcherbakova. DNA Repair (Amst), 2017 Jul 09; 56. PMID: 28687338 Free PMC article. Review.
Oncolytic viruses: adenoviruses. Julia Niemann, Florian Kühnel. Virus Genes, 2017 Jul 14; 53(5). PMID: 28702840 Review.
A perspective on the impact of radiation therapy on the immune rheostat. William H McBride, Ekambaram Ganapathy, +3 authors, Dörthe Schaue. less Br J Radiol, 2017 Jul 15; 90(1078). PMID: 28707537 Free PMC article. Review.
Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. Kimberly Loo, Katy K Tsai, +14 authors, Adil I Daud. less JCI Insight, 2017 Jul 21; 2(14). PMID: 28724802 Free PMC article.
The 'Pushmi-Pullyu' of DNA REPAIR: Clinical Synthetic Lethality. S Percy Ivy, Johann de Bono, Elise C Kohn. Trends Cancer, 2017 Jul 26; 2(11). PMID: 28741503 Free PMC article. Review.
The immune contexture in cancer prognosis and treatment. Wolf H Fridman, Laurence Zitvogel, Catherine Sautès-Fridman, Guido Kroemer. Nat Rev Clin Oncol, 2017 Jul 26; 14(12). PMID: 28741618 Highly Cited. Review.
Treatment Outcomes for Metastatic Melanoma of Unknown Primary in the New Era: A Single-Institution Study and Review of the Literature. Kierstin Utter, Chloe Goldman, +5 authors, Iman Osman. less Oncology, 2017 Jul 27; 93(4). PMID: 28746931 Free PMC article. Review.
Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors. Nathan O Siemers, James L Holloway, +4 authors, Joseph D Szustakowski. less PLoS One, 2017 Jul 28; 12(7). PMID: 28749946 Free PMC article.
The Landscape of Whole-genome Alterations and Pathologic Features in Genitourinary Malignancies: An Analysis of the Cancer Genome Atlas. Mark W Ball, Michael A Gorin, +2 authors, Charles G Drake, Hans J Hammers, Mohamad E Allaf. less Eur Urol Focus, 2017 Jul 30; 3(6). PMID: 28753846 Free PMC article.
Tools to define the melanoma-associated immunopeptidome. Eva Bräunlein, Angela M Krackhardt. Immunology, 2017 Jul 30; 152(4). PMID: 28755382 Free PMC article. Review.
Mismatch Repair Deficiency as a Predictive Biomarker for Immunotherapy Efficacy. Giulia Viale, Dario Trapani, Giuseppe Curigliano. Biomed Res Int, 2017 Aug 05; 2017. PMID: 28770222 Free PMC article. Review.
Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma. Russell Maxwell, Christopher M Jackson, Michael Lim. Curr Treat Options Oncol, 2017 Aug 09; 18(8). PMID: 28785997 Review.
Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma. Wenyong Long, Yang Yi, +3 authors, Shen Chen, Qi Cao, Wei Zhao, Qing Liu. less Front Pharmacol, 2017 Aug 10; 8. PMID: 28790919 Free PMC article. Review.
Breast Cancer Immunotherapy: Facts and Hopes. Leisha A Emens. Clin Cancer Res, 2017 Aug 13; 24(3). PMID: 28801472 Free PMC article. Highly Cited. Review.
Lung tumor exome files with T-cell receptor recombinations: a mouse model of T-cell infiltrates reflecting mutation burdens. Yaping N Tu, Wei Lue Tong, Timothy J Fawcett, George Blanck. Lab Invest, 2017 Aug 15; 97(12). PMID: 28805806
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma. Alexandre Reuben, Christine N Spencer, +51 authors, Jennifer A Wargo. less NPJ Genom Med, 2017 Aug 19; 2. PMID: 28819565 Free PMC article. Highly Cited.
Immune Dysfunction in Non-Hodgkin Lymphoma: Avenues for New Immunotherapy-Based Strategies. Lorenzo Falchi. Curr Hematol Malig Rep, 2017 Aug 20; 12(5). PMID: 28822058 Review.
Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making. Wassim Abida, Joshua Armenia, +38 authors, Howard I Scher. less JCO Precis Oncol, 2017 Aug 22; 2017. PMID: 28825054 Free PMC article. Highly Cited.
Optimizing tumor immune response through combination of radiation and immunotherapy. Alissar El Chediak, Ali Shamseddine, +3 authors, Youssef H Zeidan. less Med Oncol, 2017 Aug 23; 34(9). PMID: 28828581 Review.
Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers. Aaron M Goodman, Shumei Kato, +6 authors, Razelle Kurzrock. less Mol Cancer Ther, 2017 Aug 25; 16(11). PMID: 28835386 Free PMC article. Highly Cited.
CIMT 2017: Anniversary symposium - Report on the 15th CIMT Annual Meeting of the Association for Cancer Immunotherapy. Lena M Kranz, Jan D Beck, +3 authors, Mustafa Diken. less Hum Vaccin Immunother, 2017 Aug 29; 13(10). PMID: 28846471 Free PMC article.
Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors. Carmelo Tibaldi, Alice Lunghi, Editta Baldini. World J Clin Oncol, 2017 Aug 30; 8(4). PMID: 28848698 Free PMC article. Review.
The neoepitope landscape in pediatric cancers. Ti-Cheng Chang, Robert A Carter, +13 authors, Jinghui Zhang. less Genome Med, 2017 Sep 01; 9(1). PMID: 28854978 Free PMC article.
Glioblastoma targeted therapy: updated approaches from recent biological insights. M Touat, A Idbaih, M Sanson, K L Ligon. Ann Oncol, 2017 Sep 03; 28(7). PMID: 28863449 Free PMC article. Highly Cited. Review.
Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity. Valsamo Anagnostou, Mark Yarchoan, +6 authors, Patrick M Forde. less Clin Cancer Res, 2017 Sep 03; 23(17). PMID: 28864724 Free PMC article.
From Famine to Feast: Developing Early-Phase Combination Immunotherapy Trials Wisely. Daphne Day, Arta M Monjazeb, +4 authors, Marcus O Butler. less Clin Cancer Res, 2017 Sep 03; 23(17). PMID: 28864726 Free PMC article.
Immune checkpoint inhibitors in cancer therapy. Eika S Webb, Peng Liu, +3 authors, Yao-He Wang. less J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656 Free PMC article.
The immunologic advantage of recurrent nasopharyngeal carcinoma from the viewpoint of Galectin-9/Tim-3-related changes in the tumour microenvironment. Tseng-Cheng Chen, Chao-Hsien Chen, +6 authors, Yih-Leong Chang. less Sci Rep, 2017 Sep 06; 7(1). PMID: 28871094 Free PMC article.
Therapeutic vaccine to cure large mouse hepatocellular carcinomas. Zhen Han, De Yang, Anna Trivett, Joost J Oppenheim. Oncotarget, 2017 Sep 09; 8(32). PMID: 28881713 Free PMC article.
Clinical application of a cancer genomic profiling assay to guide precision medicine decisions. Cheryl Eifert, Angeliki Pantazi, +9 authors, Alexei Protopopov. less Per Med, 2017 Sep 12; 14(4). PMID: 28890729 Free PMC article.
Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care. Mizuki Nishino, Hiroto Hatabu, Lynette M Sholl, Nikhil H Ramaiya. Radiographics, 2017 Sep 13; 37(5). PMID: 28898185 Free PMC article. Review.
Neoantigen prediction and the need for validation. Antonella Vitiello, Maurizio Zanetti. Nat Biotechnol, 2017 Sep 13; 35(9). PMID: 28898209
Targeting Neoantigens in Glioblastoma: An Overview of Cancer Immunogenomics and Translational Implications. Tanner M Johanns, Jay A Bowman-Kirigin, Connor Liu, Gavin P Dunn. Neurosurgery, 2017 Sep 14; 64(CN_suppl_1). PMID: 28899059 Free PMC article.
Classifying the evolutionary and ecological features of neoplasms. Carlo C Maley, Athena Aktipis, +19 authors, Darryl Shibata. less Nat Rev Cancer, 2017 Sep 16; 17(10). PMID: 28912577 Free PMC article. Highly Cited. Review.
Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells. M Fehlings, Y Simoni, +7 authors, E W Newell. less Nat Commun, 2017 Sep 17; 8(1). PMID: 28916749 Free PMC article.
Emerging biomarkers for cancer immunotherapy in melanoma. Margaret L Axelrod, Douglas B Johnson, Justin M Balko. Semin Cancer Biol, 2017 Sep 18; 52(Pt 2). PMID: 28917578 Free PMC article. Review.
First report of clinical responses to immunotherapy in 3 relapsing cases of chordoma after failure of standard therapies. Denis Migliorini, Nicolas Mach, +6 authors, Pierre-Yves Dietrich. less Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28919999 Free PMC article.
The frequency of neoantigens per somatic mutation rather than overall mutational load or number of predicted neoantigens per se is a prognostic factor in ovarian clear cell carcinoma. Hirokazu Matsushita, Kosei Hasegawa, +9 authors, Kazuhiro Kakimi. less Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28920005 Free PMC article.
Dosing immunotherapy combinations: Analysis of 3,526 patients for toxicity and response patterns. Mina Nikanjam, Harsh Patel, Razelle Kurzrock. Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28920006 Free PMC article.
Relationship of tumor PD-L1 (CD274) expression with lower mortality in lung high-grade neuroendocrine tumor. Kentaro Inamura, Yusuke Yokouchi, +5 authors, Yuichi Ishikawa. less Cancer Med, 2017 Sep 20; 6(10). PMID: 28925087 Free PMC article.
Predictors of responses to immune checkpoint blockade in advanced melanoma. N Jacquelot, M P Roberti, +47 authors, L Zitvogel. less Nat Commun, 2017 Sep 21; 8(1). PMID: 28928380 Free PMC article. Highly Cited.
New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification. Joakim Crona, David Taïeb, Karel Pacak. Endocr Rev, 2017 Sep 25; 38(6). PMID: 28938417 Free PMC article. Highly Cited. Review.
Mitochondrial Metabolism: Yin and Yang for Tumor Progression. Lorea Valcarcel-Jimenez, Edoardo Gaude, +2 authors, Veronica Torrano, Christian Frezza, Arkaitz Carracedo. less Trends Endocrinol Metab, 2017 Sep 25; 28(10). PMID: 28938972 Free PMC article. Review.
Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model. Henrik Jespersen, Mattias F Lindberg, +7 authors, Jonas A Nilsson. less Nat Commun, 2017 Sep 29; 8(1). PMID: 28955032 Free PMC article.
The Potential and Challenges of Exploiting the Vast But Dynamic Neoepitope Landscape for Immunotherapy. Els M E Verdegaal, Sjoerd H van der Burg. Front Immunol, 2017 Sep 30; 8. PMID: 28959257 Free PMC article.
Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters. M Linch, G Goh, +31 authors, C Swanton. less Ann Oncol, 2017 Sep 30; 28(10). PMID: 28961847 Free PMC article.
Hypermutated Circulating Tumor DNA: Correlation with Response to Checkpoint Inhibitor-Based Immunotherapy. Yulian Khagi, Aaron M Goodman, +5 authors, Razelle Kurzrock. less Clin Cancer Res, 2017 Oct 04; 23(19). PMID: 28972084 Free PMC article. Highly Cited.
Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF. Andrea J Manrique-Rincón, Camila M Beraldo, Jessica M Toscaro, Marcio C Bajgelman. Front Immunol, 2017 Oct 05; 8. PMID: 28974950 Free PMC article.
Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. Tao Shen, Zhengming Chen, Zhizhuang Joe Zhao, Jie Wu. Oncotarget, 2017 Oct 06; 8(37). PMID: 28977839 Free PMC article.
Towards a better cancer precision medicine: systems biology meets immunotherapy. Bhavneet Bhinder, Olivier Elemento. Curr Opin Syst Biol, 2017 Oct 11; 2. PMID: 28989987 Free PMC article.
The diverse functions of the PD1 inhibitory pathway. Arlene H Sharpe, Kristen E Pauken. Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585 Highly Cited. Review.
Cholangiocarcinoma - evolving concepts and therapeutic strategies. Sumera Rizvi, Shahid A Khan, +2 authors, Gregory J Gores. less Nat Rev Clin Oncol, 2017 Oct 11; 15(2). PMID: 28994423 Free PMC article. Highly Cited. Review.
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Scott Gettinger, Jungmin Choi, +23 authors, Katerina Politi. less Cancer Discov, 2017 Oct 14; 7(12). PMID: 29025772 Free PMC article. Highly Cited.
Challenging the standard of care in advanced melanoma: focus on pembrolizumab. Raghad M Abdul-Karim, C Lance Cowey. Cancer Manag Res, 2017 Oct 14; 9. PMID: 29026335 Free PMC article. Review.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth. Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Michael Saborowski, Florian Kühnel, Norman Woller. less Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503 Free PMC article. Review.
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab. Nadeem Riaz, Jonathan J Havel, +22 authors, Timothy A Chan. less Cell, 2017 Oct 17; 171(4). PMID: 29033130 Free PMC article. Highly Cited.
Biomarkers for Response of Melanoma Patients to Immune Checkpoint Inhibitors: A Systematic Review. Charissa A C Jessurun, Julien A M Vos, Jacqueline Limpens, Rosalie M Luiten. Front Oncol, 2017 Oct 17; 7. PMID: 29034210 Free PMC article.
Clinical and molecular characterization of patients with cancer of unknown primary in the modern era. A M Varghese, A Arora, +12 authors, L B Saltz. less Ann Oncol, 2017 Oct 19; 28(12). PMID: 29045506 Free PMC article.
Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells. Tamson Moore, Courtney Regan Wagner, +23 authors, Michael I Nishimura. less Cancer Immunol Immunother, 2017 Oct 21; 67(2). PMID: 29052782 Free PMC article.
Comprehensive Analysis of Hypermutation in Human Cancer. Brittany B Campbell, Nicholas Light, +59 authors, Adam Shlien. less Cell, 2017 Oct 24; 171(5). PMID: 29056344 Free PMC article. Highly Cited.
Beyond PD-L1 testing-emerging biomarkers for immunotherapy in non-small cell lung cancer. Khinh Ranh Voong, Josephine Feliciano, Daniel Becker, Benjamin Levy. Ann Transl Med, 2017 Oct 24; 5(18). PMID: 29057236 Free PMC article. Review.
Emerging uses of circulating tumor DNA in advanced stage non-small cell lung cancer. Melina Marmarelis, Jeffrey C Thompson, +5 authors, Joshua Bauml. less Ann Transl Med, 2017 Oct 24; 5(18). PMID: 29057240 Free PMC article. Review.
Immunotherapy for Pediatric Brain Tumors. Elias J Sayour, Duane A Mitchell. Brain Sci, 2017 Oct 27; 7(10). PMID: 29065490 Free PMC article. Review.
T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma. Ingunn M Stromnes, Ayaka Hulbert, +2 authors, Robert H Pierce, Philip D Greenberg, Sunil R Hingorani. less Cancer Immunol Res, 2017 Oct 27; 5(11). PMID: 29066497 Free PMC article. Highly Cited.
Resistance to checkpoint blockade therapy through inactivation of antigen presentation. Moshe Sade-Feldman, Yunxin J Jiao, +28 authors, Nir Hacohen. less Nat Commun, 2017 Oct 27; 8(1). PMID: 29070816 Free PMC article. Highly Cited.
Immunotherapy regimens for metastatic colorectal carcinomas. Babar Bashir, Adam E Snook. Hum Vaccin Immunother, 2017 Oct 31; 14(2). PMID: 29083978 Free PMC article. Review.
Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. Martin G Dalin, Nora Katabi, +19 authors, Luc G T Morris. less Nat Commun, 2017 Nov 01; 8(1). PMID: 29084941 Free PMC article.
Expression differences of programmed death ligand 1 in de-novo and recurrent glioblastoma multiforme. Sabrina Heynckes, Annette Gaebelein, +8 authors, Dieter Henrik Heiland. less Oncotarget, 2017 Nov 02; 8(43). PMID: 29088776 Free PMC article.
Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma. Hilary R Keller, Xin Zhang, +2 authors, Li Li, Helmut Schaider, James W Wells. less Oncotarget, 2017 Nov 02; 8(43). PMID: 29088901 Free PMC article. Review.
Effects of Co-occurring Genomic Alterations on Outcomes in Patients with KRAS-Mutant Non-Small Cell Lung Cancer. Kathryn C Arbour, Emmett Jordan, +13 authors, Gregory J Riely. less Clin Cancer Res, 2017 Nov 02; 24(2). PMID: 29089357 Free PMC article.
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. V Gopalakrishnan, C N Spencer, +67 authors, J A Wargo. less Science, 2017 Nov 04; 359(6371). PMID: 29097493 Free PMC article. Highly Cited.
Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles. Klaus G Griewank, Thomas Wiesner, +12 authors, Thomas Mentzel. less Mod Pathol, 2017 Nov 04; 31(3). PMID: 29099504 Free PMC article.
Cancer Evolution during Immunotherapy. M C Andrews, J A Wargo. Cell, 2017 Nov 04; 171(4). PMID: 29100071 Free PMC article.
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution. Nicholas McGranahan, Rachel Rosenthal, +9 authors, TRACERx Consortium. less Cell, 2017 Nov 07; 171(6). PMID: 29107330 Free PMC article. Highly Cited.
New trends in antitumor vaccines in melanoma. Marcos Vasquez, Shirley Tenesaca, Pedro Berraondo. Ann Transl Med, 2017 Nov 09; 5(19). PMID: 29114542 Free PMC article. Review.
Predictive factors of response to immunotherapy-a review from the Spanish Melanoma Group (GEM). Enrique Espinosa, Ivan Márquez-Rodas, +5 authors, Spanish Melanoma Group (GEM). less Ann Transl Med, 2017 Nov 09; 5(19). PMID: 29114547 Free PMC article. Review.
Combining DNA damaging therapeutics with immunotherapy: more haste, less speed. Jessica S Brown, Raghav Sundar, Juanita Lopez. Br J Cancer, 2017 Nov 11; 118(3). PMID: 29123260 Free PMC article. Highly Cited. Review.
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Ayman Oweida, Shelby Lennon, +11 authors, Sana D Karam. less Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123967 Free PMC article.
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy. Marta Łuksza, Nadeem Riaz, +9 authors, Benjamin D Greenbaum. less Nature, 2017 Nov 14; 551(7681). PMID: 29132144 Free PMC article. Highly Cited.
Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer. Anna E Kersh, Spencer Ng, +7 authors, Brian P Pollack. less J Clin Pharmacol, 2017 Nov 15; 58(1). PMID: 29136276 Free PMC article. Review.
Immune checkpoint inhibitors: new strategies to checkmate cancer. R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs. Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554 Free PMC article. Review.
Future perspectives in melanoma research "Melanoma Bridge", Napoli, November 30th-3rd December 2016. Paolo A Ascierto, Sanjiv S Agarwala, +20 authors, Magdalena Thurin. less J Transl Med, 2017 Nov 18; 15(1). PMID: 29145885 Free PMC article.
Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4. Xuan Mo, Hanghang Zhang, +7 authors, M Raza Zaidi. less Cancer Res, 2017 Nov 19; 78(2). PMID: 29150430 Free PMC article.
Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells. Ugo Testa, Germana Castelli, Elvira Pelosi. Med Sci (Basel), 2017 Nov 22; 5(4). PMID: 29156643 Free PMC article. Review.
Biomarkers for immunotherapy in bladder cancer: a moving target. David H Aggen, Charles G Drake. J Immunother Cancer, 2017 Nov 22; 5(1). PMID: 29157296 Free PMC article. Review.
Impressive response to immunotherapy in a metastatic gastric cancer patient: could somatic copy number alterations help patient selection? Gustavo Dos Santos Fernandes, Daniel da Motta Girardi, +2 authors, Renata de Almeida Coudry. less J Immunother Cancer, 2017 Nov 22; 5(1). PMID: 29157298 Free PMC article.
Whole exome sequencing for determination of tumor mutation load in liquid biopsy from advanced cancer patients. Florence Koeppel, Steven Blanchard, +8 authors, Ludovic Lacroix. less PLoS One, 2017 Nov 22; 12(11). PMID: 29161279 Free PMC article.
Checkpoint inhibitors in endometrial cancer: preclinical rationale and clinical activity. Gloria Mittica, Eleonora Ghisoni, +3 authors, Giorgio Valabrega. less Oncotarget, 2017 Nov 23; 8(52). PMID: 29163851 Free PMC article. Review.
Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles. Alberto Grandi, Michele Tomasi, +14 authors, Guido Grandi. less Front Oncol, 2017 Nov 23; 7. PMID: 29164053 Free PMC article.
Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma. Martin Lauss, Marco Donia, +10 authors, Göran Jönsson. less Nat Commun, 2017 Nov 25; 8(1). PMID: 29170503 Free PMC article. Highly Cited.
An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors. Yong-Chen Lu, Zhili Zheng, +9 authors, Steven A Rosenberg. less Mol Ther, 2017 Nov 28; 26(2). PMID: 29174843 Free PMC article.
Targeting immune checkpoints in breast cancer: an update of early results. Cinzia Solinas, Andrea Gombos, +3 authors, Laurence Buisseret. less ESMO Open, 2017 Nov 28; 2(5). PMID: 29177095 Free PMC article. Review.
Metastatic melanoma patients' sensitivity to ipilimumab cannot be predicted by tumor characteristics. Kara Rossfeld, Erinn M Hade, +8 authors, Georgia M Beasley. less Int J Surg Oncol (N Y), 2017 Nov 28; 2(9). PMID: 29177235 Free PMC article.
Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells. Nils-Petter Rudqvist, Karsten A Pilones, +7 authors, Sandra Demaria. less Cancer Immunol Res, 2017 Nov 29; 6(2). PMID: 29180535 Free PMC article.
Uncommon BRAF Mutations Associated with Durable Response to Immunotherapy in Patients with Metastatic Melanoma. Brenen P Swofford, Jade Homsi. Case Rep Oncol Med, 2017 Nov 29; 2017. PMID: 29181212 Free PMC article.
An Analysis of Natural T Cell Responses to Predicted Tumor Neoepitopes. Anne-Mette Bjerregaard, Morten Nielsen, +4 authors, Aron Charles Eklund. less Front Immunol, 2017 Dec 01; 8. PMID: 29187854 Free PMC article.
Implications of the tumor immune microenvironment for staging and therapeutics. Janis M Taube, Jérôme Galon, +8 authors, Ashley Cimino-Mathews. less Mod Pathol, 2017 Dec 02; 31(2). PMID: 29192647 Free PMC article. Highly Cited. Review.
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. Diego Chowell, Luc G T Morris, +17 authors, Timothy A Chan. less Science, 2017 Dec 09; 359(6375). PMID: 29217585 Free PMC article. Highly Cited.
Drug development in the era of precision medicine. Sarah A Dugger, Adam Platt, David B Goldstein. Nat Rev Drug Discov, 2017 Dec 09; 17(3). PMID: 29217837 Free PMC article. Highly Cited. Review.
Towards personalized, tumour-specific, therapeutic vaccines for cancer. Zhuting Hu, Patrick A Ott, Catherine J Wu. Nat Rev Immunol, 2017 Dec 12; 18(3). PMID: 29226910 Free PMC article. Highly Cited. Review.
Navigating the "No Man's Land" of TKI-Failed EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC): A Review. Bryan Oronsky, Patrick Ma, +5 authors, Corey A Carter. less Neoplasia, 2017 Dec 12; 20(1). PMID: 29227909 Free PMC article. Review.
Nanoparticulate Delivery of Cancer Cell Membrane Elicits Multiantigenic Antitumor Immunity. Ashley V Kroll, Ronnie H Fang, +8 authors, Liangfang Zhang. less Adv Mater, 2017 Dec 15; 29(47). PMID: 29239517 Free PMC article.
Molecular Biomarkers of Primary and Acquired Resistance to T-Cell-Mediated Immunotherapy in Cancer: Landscape, Clinical Implications, and Future Directions. Young Kwang Chae, Michael S Oh, Francis J Giles. Oncologist, 2017 Dec 16; 23(4). PMID: 29242279 Free PMC article. Review.
Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma. Tatenda Mahlokozera, Ananth K Vellimana, +10 authors, Albert H Kim. less Neuro Oncol, 2017 Dec 16; 20(4). PMID: 29244145 Free PMC article.
Synergy of Immune Checkpoint Blockade with a Novel Synthetic Consensus DNA Vaccine Targeting TERT. Elizabeth K Duperret, Megan C Wise, +8 authors, David B Weiner. less Mol Ther, 2017 Dec 19; 26(2). PMID: 29249395 Free PMC article.
Identification and Characterization of Neoantigens As Well As Respective Immune Responses in Cancer Patients. Eva Bräunlein, Angela M Krackhardt. Front Immunol, 2017 Dec 19; 8. PMID: 29250075 Free PMC article. Review.
Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions. Hsiu-Chuan Wei, Jui-Ling Yu, Chia-Yu Hsu. Comput Math Methods Med, 2017 Dec 19; 2017. PMID: 29250133 Free PMC article.
Preclinical and clinical development of neoantigen vaccines. L Li, S P Goedegebuure, W E Gillanders. Ann Oncol, 2017 Dec 19; 28(suppl_12). PMID: 29253113 Free PMC article. Review.
Informatics for cancer immunotherapy. J Hammerbacher, A Snyder. Ann Oncol, 2017 Dec 19; 28(suppl_12). PMID: 29253114 Free PMC article. Review.
Understanding preanalytical variables and their effects on clinical biomarkers of oncology and immunotherapy. Lokesh Agrawal, Kelly B Engel, Sarah R Greytak, Helen M Moore. Semin Cancer Biol, 2017 Dec 21; 52(Pt 2). PMID: 29258857 Free PMC article. Review.
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer. David Liu, Philip Abbosh, +22 authors, Eliezer M Van Allen. less Nat Commun, 2017 Dec 21; 8(1). PMID: 29259186 Free PMC article.
Shared cancer neoantigens: Making private matters public. Christopher A Klebanoff, Jedd D Wolchok. J Exp Med, 2017 Dec 23; 215(1). PMID: 29269561 Free PMC article.
The Positive Relationship Between γH2AX and PD-L1 Expression in Lung Squamous Cell Carcinoma. Atsushi Osoegawa, Hitomi Hiraishi, +6 authors, Kenji Sugio. less In Vivo, 2017 Dec 25; 32(1). PMID: 29275316 Free PMC article.
Chemo-Immunotherapy: Role of Indoleamine 2,3-Dioxygenase in Defining Immunogenic Versus Tolerogenic Cell Death in the Tumor Microenvironment. Theodore S Johnson, Tracy Mcgaha, David H Munn. Adv Exp Med Biol, 2017 Dec 25; 1036. PMID: 29275467 Free PMC article. Review.
Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells. Michael P Plebanek, Debayan Bhaumik, Paul J Bryce, C Shad Thaxton. Mol Cancer Ther, 2017 Dec 29; 17(3). PMID: 29282300 Free PMC article.
Immune system and melanoma biology: a balance between immunosurveillance and immune escape. Anna Passarelli, Francesco Mannavola, +2 authors, Luigia Stefania Stucci, Marco Tucci, Francesco Silvestris. less Oncotarget, 2017 Dec 30; 8(62). PMID: 29285320 Free PMC article. Review.
Predictors of response and resistance to checkpoint inhibitors in solid tumors. Sanjana V Rao, Amy E Moran, Julie N Graff. Ann Transl Med, 2017 Dec 30; 5(23). PMID: 29285501 Free PMC article.
Cancer immunotherapy-targeted glypican-3 or neoantigens. Yasuhiro Shimizu, Toshihiro Suzuki, +4 authors, Tetsuya Nakatsura. less Cancer Sci, 2017 Dec 30; 109(3). PMID: 29285841 Free PMC article. Review.
Implementation of "clinical sequencing" in cancer genome medicine in Japan. Takashi Kohno. Cancer Sci, 2017 Dec 30; 109(3). PMID: 29285848 Free PMC article. Review.
Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens. Kazuma Kiyotani, Hiu Ting Chan, Yusuke Nakamura. Cancer Sci, 2017 Dec 31; 109(3). PMID: 29288513 Free PMC article. Review.
Mutation load and an effector T-cell gene signature may distinguish immunologically distinct and clinically relevant lymphoma subsets. Christopher R Bolen, Ronald McCord, +10 authors, Jeffrey M Venstrom. less Blood Adv, 2018 Jan 04; 1(22). PMID: 29296835 Free PMC article.
Off-the-shelf TCR for graft-versus-leukemia without GVHD. Frederick L Locke, Claudio Anasetti. Blood, 2018 Jan 06; 131(1). PMID: 29301771 Free PMC article.
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Diana Miao, Claire A Margolis, +23 authors, Eliezer M Van Allen. less Science, 2018 Jan 06; 359(6377). PMID: 29301960 Free PMC article. Highly Cited.
A novel immunization strategy using cytokine/chemokines induces new effective systemic immune responses, and frequent complete regressions of human metastatic melanoma. Fred T Valentine, Frederick M Golomb, Matthew Harris, Daniel F Roses. Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308310 Free PMC article.
Inhibitors of the PD-1 Pathway in Tumor Therapy. Martin W LaFleur, Yuki Muroyama, Charles G Drake, Arlene H Sharpe. J Immunol, 2018 Jan 10; 200(2). PMID: 29311378 Free PMC article. Review.
Neoantigen Targeting-Dawn of a New Era in Cancer Immunotherapy? Thomas C Wirth, Florian Kühnel. Front Immunol, 2018 Jan 10; 8. PMID: 29312332 Free PMC article. Highly Cited. Review.
The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy. Terhi Karpanen, Johanna Olweus. Front Immunol, 2018 Jan 13; 8. PMID: 29321773 Free PMC article. Review.
Early and Locally Advanced Metaplastic Breast Cancer: Presentation and Survival by Receptor Status in Surveillance, Epidemiology, and End Results (SEER) 2010-2014. Mary C Schroeder, Priya Rastogi, +2 authors, Charles E Geyer, Lance D Miller, Alexandra Thomas. less Oncologist, 2018 Jan 14; 23(4). PMID: 29330212 Free PMC article.
Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing. Hira Rizvi, Francisco Sanchez-Vega, +29 authors, Matthew D Hellmann. less J Clin Oncol, 2018 Jan 18; 36(7). PMID: 29337640 Free PMC article. Highly Cited.
Hypermutation and microsatellite instability in gastrointestinal cancers. Kizuki Yuza, Masayuki Nagahashi, +2 authors, Satoshi Watanabe, Kazuaki Takabe, Toshifumi Wakai. less Oncotarget, 2018 Jan 18; 8(67). PMID: 29340115 Free PMC article. Review.
Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation. Adam D Scheid, Virginia P Van Keulen, +9 authors, Larry R Pease. less J Immunol, 2018 Jan 21; 200(5). PMID: 29352003 Free PMC article.
Immunogenomics: A Negative Prostate Cancer Outcome Associated with TcR-γ/δ Recombinations. Yaping N Tu, Wei Lue Tong, John M Yavorski, George Blanck. Cancer Microenviron, 2018 Jan 23; 11(1). PMID: 29357011 Free PMC article.
Unwrapping the genomic characteristics of urothelial bladder cancer and successes with immune checkpoint blockade therapy. Wen Cheng, Dian Fu, Feng Xu, Zhengyu Zhang. Oncogenesis, 2018 Jan 24; 7(1). PMID: 29358573 Free PMC article.
Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma. Joshua R Veatch, Sylvia M Lee, +10 authors, Stanley R Riddell. less J Clin Invest, 2018 Jan 24; 128(4). PMID: 29360643 Free PMC article. Highly Cited.
Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma. E Ghorani, R Rosenthal, +5 authors, S A Quezada. less Ann Oncol, 2018 Jan 24; 29(1). PMID: 29361136 Free PMC article. Highly Cited.
Colorectal Cancers: An Update on Their Molecular Pathology. Kentaro Inamura. Cancers (Basel), 2018 Jan 25; 10(1). PMID: 29361689 Free PMC article. Highly Cited. Review.
Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations. Zishuo I Hu, Jinru Shia, +14 authors, Eileen M O'Reilly. less Clin Cancer Res, 2018 Jan 26; 24(6). PMID: 29367431 Free PMC article. Highly Cited.
Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials. Sandra P D'Angelo, Michelle R Mahoney, +8 authors, Howard Streicher. less Lancet Oncol, 2018 Jan 27; 19(3). PMID: 29370992 Free PMC article. Highly Cited.
Incorporating Radiation Oncology into Immunotherapy: proceedings from the ASTRO-SITC-NCI immunotherapy workshop. Ariel E Marciscano, Joshua M Walker, +6 authors, Mansoor M Ahmed. less J Immunother Cancer, 2018 Jan 30; 6(1). PMID: 29375032 Free PMC article.
Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients. Niki Karachaliou, Maria Gonzalez-Cao, +15 authors, Rafael Rosell. less Ther Adv Med Oncol, 2018 Feb 01; 10. PMID: 29383037 Free PMC article. Highly Cited.
Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas. Belen Hernandez, Hibret A Adissu, +3 authors, R Mark Simpson. less Int J Mol Sci, 2018 Feb 02; 19(2). PMID: 29385676 Free PMC article. Review.
Activity of pembrolizumab in relapsed/refractory NK/T-cell lymphoma. Xin Li, Yasong Cheng, +15 authors, Ken H Young. less J Hematol Oncol, 2018 Feb 02; 11(1). PMID: 29386072 Free PMC article. Highly Cited.
Bringing the next Generation of Immuno-Oncology Biomarkers to the Clinic. Alessandra Cesano, Sarah Warren. Biomedicines, 2018 Feb 03; 6(1). PMID: 29393888 Free PMC article. Highly Cited. Review.
Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy. Aurélie Durgeau, Yasemin Virk, Stéphanie Corgnac, Fathia Mami-Chouaib. Front Immunol, 2018 Feb 07; 9. PMID: 29403496 Free PMC article. Highly Cited. Review.
Genetic status of KRAS influences Transforming Growth Factor-beta (TGF-β) signaling: An insight into Neuropilin-1 (NRP1) mediated tumorigenesis. Sneha Vivekanandhan, Debabrata Mukhopadhyay. Semin Cancer Biol, 2018 Feb 08; 54. PMID: 29409705 Free PMC article. Review.
Emerging Biomarkers in Cutaneous Melanoma. Anna Eisenstein, Estela Chen Gonzalez, +6 authors, Rhoda M Alani. less Mol Diagn Ther, 2018 Feb 08; 22(2). PMID: 29411301 Review.
A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer. Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang. Transl Oncol, 2018 Feb 08; 11(2). PMID: 29413765 Free PMC article. Highly Cited.
Exome sequencing reveals aberrant signalling pathways as hallmark of treatment-naive anal squamous cell carcinoma. Wulfran Cacheux, Virginie Dangles-Marie, +17 authors, Astrid Lièvre. less Oncotarget, 2018 Feb 09; 9(1). PMID: 29416628 Free PMC article.
Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer. Philip H Abbosh, Elizabeth R Plimack. Bladder Cancer, 2018 Feb 13; 4(1). PMID: 29430503 Free PMC article. Review.
Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients. Ari Vanderwalde, David Spetzler, +2 authors, Nianqing Xiao, Zoran Gatalica, John Marshall. less Cancer Med, 2018 Feb 13; 7(3). PMID: 29436178 Free PMC article. Highly Cited.
Immune Checkpoint Blockade: The New Frontier in Cancer Treatment. Jeffrey M Clarke, Daniel J George, Stacey Lisi, April K S Salama. Target Oncol, 2018 Feb 15; 13(1). PMID: 29441437
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Sanjeev Mariathasan, Shannon J Turley, +39 authors, Thomas Powles. less Nature, 2018 Feb 15; 554(7693). PMID: 29443960 Free PMC article. Highly Cited.
Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection. Scott Balsitis, Volodymyr Gali, +16 authors, Daniel J Tenney. less PLoS One, 2018 Feb 15; 13(2). PMID: 29444087 Free PMC article.
Temozolomide-associated hypermutation in gliomas. Serah Choi, Yao Yu, +3 authors, Joseph F Costello. less Neuro Oncol, 2018 Feb 17; 20(10). PMID: 29452419 Free PMC article. Highly Cited. Review.
Re-Emergence of Dendritic Cell Vaccines for Cancer Treatment. Mansi Saxena, Nina Bhardwaj. Trends Cancer, 2018 Feb 21; 4(2). PMID: 29458962 Free PMC article. Highly Cited. Review.
Peripheral blood clinical laboratory variables associated with outcomes following combination nivolumab and ipilimumab immunotherapy in melanoma. Samuel Rosner, Erica Kwong, +9 authors, Michael A Postow. less Cancer Med, 2018 Feb 23; 7(3). PMID: 29468834 Free PMC article. Highly Cited.
Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy. Yared Hailemichael, Amber Woods, +17 authors, Willem W Overwijk. less J Clin Invest, 2018 Feb 27; 128(4). PMID: 29480817 Free PMC article. Highly Cited.
Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma. Young Kwang Chae, Jonathan F Anker, +3 authors, Jeffrey H Chuang. less Oncotarget, 2018 Mar 01; 9(8). PMID: 29487705 Free PMC article.
CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. P S Zeiner, J Zinke, +16 authors, P N Harter. less Acta Neuropathol Commun, 2018 Mar 02; 6(1). PMID: 29490700 Free PMC article.
Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma. Daniel Xia, Ruben Casanova, +4 authors, Alex Soltermann. less Sci Rep, 2018 Mar 04; 8(1). PMID: 29500362 Free PMC article.
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis. Constantinos Roufas, Dimitrios Chasiotis, +3 authors, Apostolos Zaravinos. less Front Oncol, 2018 Mar 09; 8. PMID: 29515971 Free PMC article.
New therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles. Takahiro Nakagomi, Taichiro Goto, +8 authors, Masao Omata. less Oncotarget, 2018 Mar 15; 9(12). PMID: 29535832 Free PMC article.
Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer. Sara Bobisse, Raphael Genolet, +21 authors, Alexandre Harari. less Nat Commun, 2018 Mar 17; 9(1). PMID: 29545564 Free PMC article. Highly Cited.
Current status and perspectives in immunotherapy for metastatic melanoma. Riccardo Marconcini, Francesco Spagnolo, +13 authors, Italian Melanoma Intergroup (IMI). less Oncotarget, 2018 Mar 20; 9(15). PMID: 29552325 Free PMC article. Review.
Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma. Gao Zhang, Lawrence W Wu, +41 authors, Jerry W Shay. less Clin Cancer Res, 2018 Mar 23; 24(19). PMID: 29563139 Free PMC article.
Current status of immunotherapy and immune biomarkers in gastro-esophageal cancers. Nischala Ammannagari, Ajlan Atasoy. J Gastrointest Oncol, 2018 Mar 23; 9(1). PMID: 29564185 Free PMC article. Review.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada. less Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375 Free PMC article. Highly Cited.
Erlotinib in the treatment of recurrent or metastatic cutaneous squamous cell carcinoma: A single-arm phase 2 clinical trial. Kathryn A Gold, Merrill S Kies, +3 authors, Bonnie S Glisson. less Cancer, 2018 Mar 27; 124(10). PMID: 29579331 Free PMC article.
Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments. Johan Karlsson, Hannah J Vaughan, Jordan J Green. Annu Rev Chem Biomol Eng, 2018 Mar 27; 9. PMID: 29579402 Free PMC article. Review.
Perspectives on the clinical development of immunotherapy in prostate cancer. Lisa M Cordes, James L Gulley, Ravi A Madan. Asian J Androl, 2018 Mar 28; 20(3). PMID: 29582792 Free PMC article. Review.
Distinctive features of immunostaining and mutational load in primary pulmonary enteric adenocarcinoma: implications for differential diagnosis and immunotherapy. Ming Chen, Pu Liu, +5 authors, Peng Shen. less J Transl Med, 2018 Mar 29; 16(1). PMID: 29587865 Free PMC article.
Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes. Kalpana Mujoo, Clayton R Hunt, +5 authors, Tej K Pandita. less Mol Cancer Res, 2018 Mar 30; 16(8). PMID: 29592896 Free PMC article. Review.
Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide. Yohei Takeda, Masahiro Azuma, +3 authors, Tsukasa Seya. less Front Immunol, 2018 Mar 30; 9. PMID: 29593736 Free PMC article.
Immune checkpoint inhibitors in small cell lung cancer. Suchita Pakkala, Taofeek K Owonikoko. J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593891 Free PMC article. Review.
Tumor immunity landscape in non-small cell lung cancer. Xiaoqing Yu, Xuefeng Wang. PeerJ, 2018 Mar 30; 6. PMID: 29593943 Free PMC article.
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers. Daniel J McGrail, Lorenzo Federico, +6 authors, Nidhi Sahni. less Nat Commun, 2018 Apr 05; 9(1). PMID: 29615613 Free PMC article.
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. Randi B Gombos, Ana Gonzalez, +24 authors, Nicholas S Wilson. less PLoS One, 2018 Apr 05; 13(4). PMID: 29617360 Free PMC article.
Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination. Tyler W Hulett, Shawn M Jensen, +6 authors, Bernard A Fox. less J Immunother Cancer, 2018 Apr 06; 6(1). PMID: 29618380 Free PMC article.
Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma. Hyun-Sung Lee, Hee-Jin Jang, +11 authors, Bryan M Burt. less JCI Insight, 2018 Apr 06; 3(7). PMID: 29618661 Free PMC article.
Combination Immunotherapy: Taking Cancer Vaccines to the Next Level. Jeremy M Grenier, Stephen T Yeung, Kamal M Khanna. Front Immunol, 2018 Apr 07; 9. PMID: 29623082 Free PMC article. Review.
Immunotherapy of melanoma. Iwona Lugowska, Pawel Teterycz, Piotr Rutkowski. Contemp Oncol (Pozn), 2018 Apr 10; 22(1A). PMID: 29628796 Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies. Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok. Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946 Free PMC article. Highly Cited. Review.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations. Judith A Seidel, Atsushi Otsuka, Kenji Kabashima. Front Oncol, 2018 Apr 13; 8. PMID: 29644214 Free PMC article. Highly Cited. Review.
Population-level distribution and putative immunogenicity of cancer neoepitopes. Mary A Wood, Mayur Paralkar, +6 authors, Reid F Thompson. less BMC Cancer, 2018 Apr 15; 18(1). PMID: 29653567 Free PMC article.
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Sachet A Shukla, Pavan Bachireddy, +29 authors, Catherine J Wu. less Cell, 2018 Apr 17; 173(3). PMID: 29656892 Free PMC article. Highly Cited.
Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer. Matthew D Hellmann, Tavi Nathanson, +29 authors, Jedd D Wolchok. less Cancer Cell, 2018 Apr 17; 33(5). PMID: 29657128 Free PMC article. Highly Cited.
Melanoma: What do all the mutations mean? Elizabeth J Davis, Douglas B Johnson, Jeffrey A Sosman, Sunandana Chandra. Cancer, 2018 Apr 18; 124(17). PMID: 29663336 Free PMC article. Review.
The perfect personalized cancer therapy: cancer vaccines against neoantigens. Luigi Aurisicchio, Matteo Pallocca, Gennaro Ciliberto, Fabio Palombo. J Exp Clin Cancer Res, 2018 Apr 22; 37(1). PMID: 29678194 Free PMC article. Review.
APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer. Shixiang Wang, Mingming Jia, Zaoke He, Xue-Song Liu. Oncogene, 2018 Apr 27; 37(29). PMID: 29695832 Free PMC article. Highly Cited.
BRCA1/2 and TP53 mutation status associates with PD-1 and PD-L1 expression in ovarian cancer. Verena Wieser, Inge Gaugg, +7 authors, Christian Marth. less Oncotarget, 2018 May 01; 9(25). PMID: 29707124 Free PMC article.
Increased immune infiltration and chemokine receptor expression in head and neck epithelial tumors after neoadjuvant immunotherapy with the IRX-2 regimen. Neil L Berinstein, Michael McNamara, +2 authors, Ariane Nguyen, James Egan, Gregory T Wolf. less Oncoimmunology, 2018 May 04; 7(5). PMID: 29721379 Free PMC article.
Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab. Anders H Kverneland, Christian Enevold, +3 authors, Claus H Nielsen. less Oncoimmunology, 2018 May 04; 7(5). PMID: 29721387 Free PMC article.
Review of diagnostic, prognostic, and predictive biomarkers in melanoma. Jacob S Ankeny, Brian Labadie, +3 authors, Jason Luke, Eddy Hsueh, Jane Messina, Jonathan S Zager. less Clin Exp Metastasis, 2018 May 04; 35(5-6). PMID: 29722000 Review.
Mutation load estimation model as a predictor of the response to cancer immunotherapy. Guan-Yi Lyu, Yu-Hsuan Yeh, Yi-Chen Yeh, Yu-Chao Wang. NPJ Genom Med, 2018 May 08; 3. PMID: 29736260 Free PMC article.
Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden. Carl Morrison, Sarabjot Pabla, +33 authors, Marc S Ernstoff. less J Immunother Cancer, 2018 May 11; 6(1). PMID: 29743104 Free PMC article.
Approaches to Improve Chemically Defined Synthetic Peptide Vaccines. Brett J Hos, Elena Tondini, Sander I van Kasteren, Ferry Ossendorp. Front Immunol, 2018 May 15; 9. PMID: 29755468 Free PMC article. Review.
Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma. Jeffrey P North, Justin Golovato, +12 authors, Raymond J Cho. less Nat Commun, 2018 May 16; 9(1). PMID: 29760388 Free PMC article.
A Convergence-Based Framework for Cancer Drug Resistance. David J Konieczkowski, Cory M Johannessen, Levi A Garraway. Cancer Cell, 2018 May 16; 33(5). PMID: 29763622 Free PMC article. Highly Cited. Review.
Targeted therapy or immunotherapy? Optimal treatment in hepatocellular carcinoma. Merly Contratto, Jennifer Wu. World J Gastrointest Oncol, 2018 May 18; 10(5). PMID: 29770170 Free PMC article. Review.
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma. Ferdinandos Skoulidis, Michael E Goldberg, +66 authors, John V Heymach. less Cancer Discov, 2018 May 19; 8(7). PMID: 29773717 Free PMC article. Highly Cited.
Concepts Collide: Genomic, Immune, and Microbial Influences on the Tumor Microenvironment and Response to Cancer Therapy. Miles C Andrews, Alexandre Reuben, Vancheswaran Gopalakrishnan, Jennifer A Wargo. Front Immunol, 2018 May 22; 9. PMID: 29780391 Free PMC article. Review.
Vaccine immunotherapy with ARNAX induces tumor-specific memory T cells and durable anti-tumor immunity in mouse models. Yohei Takeda, Sumito Yoshida, +4 authors, Misako Matsumoto. less Cancer Sci, 2018 May 24; 109(7). PMID: 29791768 Free PMC article.
TP53 Mutation as Potential Negative Predictor for Response of Anti-CTLA-4 Therapy in Metastatic Melanoma. Wenjing Xiao, Nan Du, +10 authors, Jing Chen. less EBioMedicine, 2018 May 26; 32. PMID: 29793878 Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer. Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang. less J Mol Biol, 2018 May 26; 430(14). PMID: 29800567 Free PMC article. Review.
An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0. Ryan J Sullivan, Michael B Atkins, +25 authors, Howard L Kaufman. less J Immunother Cancer, 2018 Jun 01; 6(1). PMID: 29848375 Free PMC article.
Advanced small cell lung cancer (SCLC): new challenges and new expectations. Nikolaos Tsoukalas, Eleni Aravantinou-Fatorou, +5 authors, George Kyrgias. less Ann Transl Med, 2018 Jun 05; 6(8). PMID: 29862234 Free PMC article. Review.
Precision medicine based on surgical oncology in the era of genome-scale analysis and genome editing technology. Shinji Tanaka. Ann Gastroenterol Surg, 2018 Jun 05; 2(2). PMID: 29863171 Free PMC article. Review.
Multiplex bead-based measurement of humoral immune responses against tumor-associated antigens in stage II melanoma patients of the EORTC18961 trial. Judith Michels, Natalia Becker, +11 authors, Inka Zörnig. less Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872552 Free PMC article.
Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial. Poulam M Patel, Christian H Ottensmeier, +15 authors, Lindy G Durrant. less Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872563 Free PMC article.
Cancer immunotherapy: broadening the scope of targetable tumours. Jitske van den Bulk, Els Me Verdegaal, Noel Fcc de Miranda. Open Biol, 2018 Jun 08; 8(6). PMID: 29875199 Free PMC article. Review.
Immune checkpoint inhibitors in urothelial cancer: recent updates and future outlook. Dharmesh Gopalakrishnan, Vadim S Koshkin, +2 authors, Petros Grivas. less Ther Clin Risk Manag, 2018 Jun 13; 14. PMID: 29892196 Free PMC article. Review.
Molecular profiles and tumor mutational burden analysis in Chinese patients with gynecologic cancers. Min Wang, Wensheng Fan, +11 authors, Yuanguang Meng. less Sci Rep, 2018 Jun 14; 8(1). PMID: 29895933 Free PMC article.
Melanoma Immunotherapy: Next-Generation Biomarkers. Sabrina A Hogan, Mitchell P Levesque, Phil F Cheng. Front Oncol, 2018 Jun 14; 8. PMID: 29896449 Free PMC article. Review.
Pathogenesis of Skin Carcinomas and a Stem Cell as Focal Origin. Frank R de Gruijl, Cornelis P Tensen. Front Med (Lausanne), 2018 Jun 14; 5. PMID: 29896477 Free PMC article. Review.
Breast Cancer Immunotherapy: An Update. Issam Makhoul, Mohammad Atiq, Ahmed Alwbari, Thomas Kieber-Emmons. Breast Cancer (Auckl), 2018 Jun 15; 12. PMID: 29899661 Free PMC article. Review.
The possibility of cancer immune editing in gliomas. A critical review. Víctor A Arrieta, Bernardo Cacho-Díaz, +3 authors, Junfei Zhao, Raul Rabadan, Li Chen, Adam M Sonabend. less Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900059 Free PMC article. Review.
Understanding Intratumor Heterogeneity and Evolution in NSCLC and Potential New Therapeutic Approach. Taichiro Goto, Yosuke Hirotsu, +2 authors, Kenji Amemiya, Hitoshi Mochizuki, Masao Omata. less Cancers (Basel), 2018 Jun 23; 10(7). PMID: 29932159 Free PMC article. Review.
Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma. Leonardo Vinícius Monteiro de Assis, Gabriela Sarti Kinker, +3 authors, Ana Maria de Lauro Castrucci. less Front Oncol, 2018 Jun 28; 8. PMID: 29946530 Free PMC article.
Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment. Elizabeth A Comen, Robert L Bowman, Maria Kleppe. Front Cell Dev Biol, 2018 Jun 28; 6. PMID: 29946544 Free PMC article. Review.
Pediatric Cancer Immunotherapy: Opportunities and Challenges. Mary Frances Wedekind, Nicholas L Denton, Chun-Yu Chen, Timothy P Cripe. Paediatr Drugs, 2018 Jun 28; 20(5). PMID: 29948928 Free PMC article. Review.
Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors. Anshuman Panda, Anil Betigeri, +14 authors, Shridar Ganesan. less JCO Precis Oncol, 2017 Jan 01; 2017. PMID: 29951597 Free PMC article.
Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers. Muhammad Umair Mushtaq, Athanasios Papadas, +4 authors, Fotis Asimakopoulos. less J Immunother Cancer, 2018 Jul 05; 6(1). PMID: 29970158 Free PMC article. Review.
Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy. Nobuo Kondoh, Masako Mizuno-Kamiya, +5 authors, Iwai Tohnai. less Open Dent J, 2018 Jul 11; 12. PMID: 29988281 Free PMC article. Review.
Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond. Emily M Lin, Jun Gong, Samuel J Klempner, Joseph Chao. World J Gastroenterol, 2018 Jul 12; 24(25). PMID: 29991874 Free PMC article. Review.
Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy). Paolo A Ascierto, James Brugarolas, +16 authors, Igor Puzanov. less J Immunother Cancer, 2018 Jul 13; 6(1). PMID: 29996914 Free PMC article. Review.
Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy. Chongkai Wang, Jun Gong, +2 authors, Travis Y Tu, Peter P Lee, Marwan Fakih. less J Gastrointest Oncol, 2018 Jul 13; 9(3). PMID: 29998005 Free PMC article.
Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies. Vanessa M Tubb, Deborah S Schrikkema, +7 authors, Gavin M Bendle. less J Immunother Cancer, 2018 Jul 14; 6(1). PMID: 30001747 Free PMC article.
Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges. Lorenzo Pilla, Cristina Maccalli. Biomedicines, 2018 Jul 14; 6(3). PMID: 30004433 Free PMC article. Review.
Novel frontiers in detecting cancer metastasis. Stanley P Leong, Carmen Ballesteros-Merino, +4 authors, Mojca Skoberne. less Clin Exp Metastasis, 2018 Jul 20; 35(5-6). PMID: 30022365 Review.
Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies. Anna Minchom, Caterina Aversa, Juanita Lopez. Ther Adv Med Oncol, 2018 Jul 20; 10. PMID: 30023007 Free PMC article. Review.
The Tumor Mutational Burden of Chinese Advanced Cancer Patients Estimated by a 381-cancer-gene Panel. Wu Zhuang, Junxun Ma, +14 authors, Zhijie Wang. less J Cancer, 2018 Jul 22; 9(13). PMID: 30026825 Free PMC article.
The evolving immunotherapeutic landscape in advanced oesophagogastric cancer. Michael Flynn, Kate Young, David Cunningham, Naureen Starling. Ther Adv Med Oncol, 2018 Jul 24; 10. PMID: 30034550 Free PMC article. Review.
Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series. Enric Domingo, Carme Camps, +26 authors, Ian Tomlinson. less Lancet Gastroenterol Hepatol, 2018 Jul 26; 3(9). PMID: 30042065 Free PMC article.
Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration. Ayman Oweida, Mohammad K Hararah, +14 authors, Sana D Karam. less Clin Cancer Res, 2018 Jul 26; 24(21). PMID: 30042205 Free PMC article. Highly Cited.
Immunogenomics Analysis Reveals that TP53 Mutations Inhibit Tumor Immunity in Gastric Cancer. Zehang Jiang, Zhixian Liu, +2 authors, Mengyuan Li, Cai Chen, Xiaosheng Wang. less Transl Oncol, 2018 Jul 31; 11(5). PMID: 30059832 Free PMC article.
Role of Immunotherapy for Oncogene-Driven Non-Small Cell Lung Cancer. Yosuke Miura, Noriaki Sunaga. Cancers (Basel), 2018 Aug 01; 10(8). PMID: 30060457 Free PMC article. Review.
Emerging strategies for combination checkpoint modulators in cancer immunotherapy. Aleksandra Popovic, Elizabeth M Jaffee, Neeha Zaidi. J Clin Invest, 2018 Aug 02; 128(8). PMID: 30067248 Free PMC article. Highly Cited. Review.
Emerging biomarkers and targeted therapies in urothelial carcinoma. Prateek Mendiratta, Petros Grivas. Ann Transl Med, 2018 Aug 03; 6(12). PMID: 30069452 Free PMC article. Review.
Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer. Jingying Nong, Yuhua Gong, +24 authors, Jinghui Wang. less Nat Commun, 2018 Aug 08; 9(1). PMID: 30082701 Free PMC article.
Checkpoint blockade-based immunotherapy in the context of tumor microenvironment: Opportunities and challenges. Jingjing Duan, Yu Wang, Shunchang Jiao. Cancer Med, 2018 Aug 09; 7(9). PMID: 30088347 Free PMC article. Review.
The Cancer Omics Atlas: an integrative resource for cancer omics annotations. Qingrong Sun, Mengyuan Li, Xiaosheng Wang. BMC Med Genomics, 2018 Aug 10; 11(1). PMID: 30089500 Free PMC article.
Predicting Antigen Presentation-What Could We Learn From a Million Peptides? David Gfeller, Michal Bassani-Sternberg. Front Immunol, 2018 Aug 10; 9. PMID: 30090105 Free PMC article. Highly Cited. Review.
Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy. Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes Vom Berg. Front Oncol, 2018 Aug 10; 8. PMID: 30090763 Free PMC article. Review.
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers. S N Gettinger, J Choi, +19 authors, K A Schalper. less Nat Commun, 2018 Aug 12; 9(1). PMID: 30097571 Free PMC article.
Metastatic Melanoma: Recent Therapeutic Progress and Future Perspectives. Nausicaa Malissen, Jean-Jacques Grob. Drugs, 2018 Aug 12; 78(12). PMID: 30097888 Review.
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. Joo Sang Lee, Lital Adler, +31 authors, Ayelet Erez. less Cell, 2018 Aug 14; 174(6). PMID: 30100185 Free PMC article.
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo. Sarwish Rafiq, Oladapo O Yeku, +14 authors, Renier J Brentjens. less Nat Biotechnol, 2018 Aug 14; 36(9). PMID: 30102295 Free PMC article. Highly Cited.
Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines. Feng Qiu, Kyle W Becker, +6 authors, John T Wilson. less Biomaterials, 2018 Aug 15; 182. PMID: 30107272 Free PMC article.
Intron retention is a source of neoepitopes in cancer. Alicia C Smart, Claire A Margolis, +6 authors, Eliezer M Van Allen. less Nat Biotechnol, 2018 Aug 17; 36(11). PMID: 30114007 Free PMC article. Highly Cited.
Abscopal effect of radiotherapy combined with immune checkpoint inhibitors. Yang Liu, Yinping Dong, +3 authors, Li Kong, Fang Shi, Hui Zhu, Jinming Yu. less J Hematol Oncol, 2018 Aug 18; 11(1). PMID: 30115069 Free PMC article. Highly Cited. Review.
Identification of non-mutated neoantigens presented by TAP-deficient tumors. Koen A Marijt, Laura Blijleven, +7 authors, Thorbald van Hall. less J Exp Med, 2018 Aug 18; 215(9). PMID: 30115740 Free PMC article.
Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer. Nataly Manjarrez-Orduño, Laurence C Menard, +15 authors, Steven G Nadler. less Front Immunol, 2018 Aug 21; 9. PMID: 30123214 Free PMC article.
Predictive biomarkers for immune checkpoint inhibitor therapy: we need to keep searching. Mary M Huerter, Apar Kishor Ganti. J Thorac Dis, 2018 Aug 21; 10(Suppl 18). PMID: 30123559 Free PMC article.
Immunological-based approaches for cancer therapy. Luciana Barros, Marco Antonio Pretti, +3 authors, Martin Hernán Bonamino. less Clinics (Sao Paulo), 2018 Aug 23; 73(suppl 1). PMID: 30133560 Free PMC article. Review.
Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma. Anshuman Panda, Aguirre A de Cubas, +10 authors, W Kimryn Rathmell. less JCI Insight, 2018 Aug 24; 3(16). PMID: 30135306 Free PMC article.
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance. Young-Jun Park, Da-Sol Kuen, Yeonseok Chung. Exp Mol Med, 2018 Aug 24; 50(8). PMID: 30135516 Free PMC article. Highly Cited. Review.
Clinical and genetic associations with prostacyclin response in pulmonary arterial hypertension. Stephen J Halliday, Meng Xu, +10 authors, Anna R Hemnes. less Pulm Circ, 2018 Aug 25; 8(4). PMID: 30142026 Free PMC article.
Precision medicine in cholangiocarcinoma. Antonio Pellino, Fotios Loupakis, +6 authors, Luca Fabris. less Transl Gastroenterol Hepatol, 2018 Aug 28; 3. PMID: 30148225 Free PMC article. Review.
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. Diana Miao, Claire A Margolis, +28 authors, Eliezer M Van Allen. less Nat Genet, 2018 Aug 29; 50(9). PMID: 30150660 Free PMC article. Highly Cited.
Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition. David A Fabrizio, Thomas J George, +13 authors, Samuel J Klempner. less J Gastrointest Oncol, 2018 Aug 29; 9(4). PMID: 30151257 Free PMC article. Highly Cited.
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options. Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül. Front Immunol, 2018 Aug 31; 9. PMID: 30158932 Free PMC article. Review.
Strategies for Predicting Response to Checkpoint Inhibitors. Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub. Curr Hematol Malig Rep, 2018 Aug 31; 13(5). PMID: 30159703 Free PMC article. Review.
Identifying neoantigens for use in immunotherapy. Sharon Hutchison, Antonia L Pritchard. Mamm Genome, 2018 Sep 01; 29(11-12). PMID: 30167844 Free PMC article. Review.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity. Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar. J Autoimmun, 2018 Sep 04; 95. PMID: 30174217 Free PMC article. Review.
T Cell-Inflamed versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection. Jonathan A Trujillo, Randy F Sweis, Riyue Bao, Jason J Luke. Cancer Immunol Res, 2018 Sep 06; 6(9). PMID: 30181337 Free PMC article. Highly Cited.
A Comprehensive Survey of Immune Cytolytic Activity-Associated Gene Co-Expression Networks across 17 Tumor and Normal Tissue Types. Tian Tian, Ji Wan, +5 authors, Zhi Wei. less Cancers (Basel), 2018 Sep 06; 10(9). PMID: 30181502 Free PMC article.
Activation of viral defense signaling in cancer. Maria Gonzalez-Cao, Niki Karachaliou, +3 authors, Rafael Rosell. less Ther Adv Med Oncol, 2018 Sep 06; 10. PMID: 30181782 Free PMC article. Review.
Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models. Roberto R Rosato, Daniel Dávila-González, +6 authors, Jenny C Chang. less Breast Cancer Res, 2018 Sep 07; 20(1). PMID: 30185216 Free PMC article.
Immune Checkpoint Inhibitors: Toward New Paradigms in Renal Cell Carcinoma. Ronan Flippot, Bernard Escudier, Laurence Albiges. Drugs, 2018 Sep 07; 78(14). PMID: 30187355 Review.
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis. William P D Hendricks, Victoria Zismann, +24 authors, Jeffrey M Trent. less PLoS Genet, 2018 Sep 07; 14(9). PMID: 30188888 Free PMC article.
From personalized to patient-specific treatment of metastatic melanoma. Robert O Dillman. Melanoma Manag, 2015 Aug 01; 2(3). PMID: 30190848 Free PMC article.
Immune checkpoint inhibitors in melanoma. Adam J Cooper, Matteo S Carlino, Richard F Kefford. Melanoma Manag, 2015 Aug 01; 2(3). PMID: 30190854 Free PMC article. Review.
Targeting immune checkpoints in melanoma: an update. Rodrigo R Munhoz, Alejandro Falcón González, Vanessa A Reed, Michael A Postow. Melanoma Manag, 2015 Nov 01; 2(4). PMID: 30190862 Free PMC article. Review.
Immunotherapy for uveal melanoma. Dae Won Kim, Jaime Anderson, Sapna P Patel. Melanoma Manag, 2016 Jun 01; 3(2). PMID: 30190881 Free PMC article. Review.
Neoadjuvant treatment for melanoma: current challenges and future perspectives. Yana G Najjar, John M Kirkwood. Melanoma Manag, 2016 Jun 01; 3(2). PMID: 30190883 Free PMC article. Review.
The cutting edge of metastatic melanoma therapy. Antonia Digklia, Olivier Michielin. Melanoma Manag, 2016 Sep 01; 3(3). PMID: 30190891 Free PMC article. Review.
Immuno-Oncology: Emerging Targets and Combination Therapies. Henry T Marshall, Mustafa B A Djamgoz. Front Oncol, 2018 Sep 08; 8. PMID: 30191140 Free PMC article. Highly Cited. Review.
A cancer vaccine with dendritic cells differentiated with GM-CSF and IFNα and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model. Ananda Mookerjee, Michele Graciotti, Lana E Kandalaft, Lana Kandalaft. Bioimpacts, 2018 Sep 14; 8(3). PMID: 30211081 Free PMC article.
Immune Checkpoint Inhibition in Head and Neck Cancer. Martin David Forster, Michael-John Devlin. Front Oncol, 2018 Sep 14; 8. PMID: 30211111 Free PMC article. Review.
Clinical Relevance of Genomic Changes in Recurrent Pediatric Solid Tumors. Boram Lee, Ji Won Lee, +6 authors, Woong-Yang Park. less Transl Oncol, 2018 Sep 15; 11(6). PMID: 30216764 Free PMC article.
Clinical implication of tumor mutational burden in patients with HER2-positive refractory metastatic breast cancer. Song Ee Park, Kyunghee Park, +9 authors, Yeon Hee Park. less Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221068 Free PMC article.
TSNAdb: A Database for Tumor-specific Neoantigens from Immunogenomics Data Analysis. Jingcheng Wu, Wenyi Zhao, +4 authors, Shuqing Chen. less Genomics Proteomics Bioinformatics, 2018 Sep 18; 16(4). PMID: 30223042 Free PMC article.
Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer. Fabian Coscia, Ernst Lengyel, +12 authors, Marion Curtis. less Cell, 2018 Sep 23; 175(1). PMID: 30241606 Free PMC article.
Genomic Characterization of Six Virus-Associated Cancers Identifies Changes in the Tumor Immune Microenvironment and Altered Genetic Programs. Frederick S Varn, Evelien Schaafsma, Yue Wang, Chao Cheng. Cancer Res, 2018 Sep 27; 78(22). PMID: 30254145 Free PMC article.
Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment. Yien Ning Sophia Wong, Kroopa Joshi, +22 authors, Sergio A Quezada. less J Exp Med, 2018 Sep 28; 215(11). PMID: 30257862 Free PMC article.
Immune Marker Profiling and Programmed Death Ligand 1 Expression Across NSCLC Mutations. Maria I Toki, Nikita Mani, +7 authors, David L Rimm. less J Thorac Oncol, 2018 Sep 30; 13(12). PMID: 30267840 Free PMC article.
DNA repair defects and implications for immunotherapy. Katherine M Bever, Dung T Le. J Clin Invest, 2018 Oct 03; 128(10). PMID: 30272580 Free PMC article. Review.
Roles of the immune system in cancer: from tumor initiation to metastatic progression. Hugo Gonzalez, Catharina Hagerling, Zena Werb. Genes Dev, 2018 Oct 03; 32(19-20). PMID: 30275043 Free PMC article. Highly Cited. Review.
PD1/PDL1 inhibitors for the treatment of advanced urothelial bladder cancer. David D Stenehjem, Dao Tran, Michael A Nkrumah, Shilpa Gupta. Onco Targets Ther, 2018 Oct 03; 11. PMID: 30275703 Free PMC article. Review.
Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option. Maartje W Rohaan, Joost H van den Berg, Pia Kvistborg, John B A G Haanen. J Immunother Cancer, 2018 Oct 05; 6(1). PMID: 30285902 Free PMC article. Review.
Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences. Xinyu Yan, Shouyue Zhang, +3 authors, Yun Deng, Peiqi Wang, Qianqian Hou, Heng Xu. less Front Pharmacol, 2018 Oct 09; 9. PMID: 30294272 Free PMC article. Review.
The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis. Caspar Mewes, Benedikt Büttner, +8 authors, Ashham Mansur. less Sci Rep, 2018 Oct 13; 8(1). PMID: 30310101 Free PMC article.
Patterns, predictors and subsequent outcomes of disease progression in metastatic renal cell carcinoma patients treated with nivolumab. Haris Zahoor, Pedro C Barata, +8 authors, Brian I Rini. less J Immunother Cancer, 2018 Oct 20; 6(1). PMID: 30333065 Free PMC article.
Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer. Heather L Kinkead, Alexander Hopkins, +12 authors, Neeha Zaidi. less JCI Insight, 2018 Oct 20; 3(20). PMID: 30333318 Free PMC article.
Therapeutic Sequencing in Metastatic Renal Cell Carcinoma. Manuel Caitano Maia, Nazli Dizman, Meghan Salgia, Sumanta Kumar Pal. Kidney Cancer, 2017 Jul 26; 1(1). PMID: 30334001 Free PMC article. Review.
Unique true predicted neoantigens (TPNAs) correlates with anti-tumor immune control in HCC patients. Annacarmen Petrizzo, Maria Tagliamonte, +9 authors, Luigi Buonaguro. less J Transl Med, 2018 Oct 21; 16(1). PMID: 30340600 Free PMC article.
Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer. Chun-Chin Chen, Weiran Feng, +2 authors, Pei Xin Lim, Elizabeth M Kass, Maria Jasin. less Annu Rev Cancer Biol, 2018 Oct 23; 2. PMID: 30345412 Free PMC article. Highly Cited.
Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Michael T Bethune, Xiao-Hua Li, +15 authors, David Baltimore. less Proc Natl Acad Sci U S A, 2018 Oct 24; 115(45). PMID: 30348802 Free PMC article.
Defective transcription elongation in a subset of cancers confers immunotherapy resistance. Vishnu Modur, Navneet Singh, +14 authors, Kakajan Komurov. less Nat Commun, 2018 Oct 26; 9(1). PMID: 30353012 Free PMC article.
Exploring optimal sequencing of radiation and immunotherapy combinations. Andrew J Gunderson, Kristina H Young. Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370348 Free PMC article. Review.
The DNA damage response in immunotherapy and radiation. Robert M Samstein, Nadeem Riaz. Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370352 Free PMC article. Review.
SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics. Franziska Singer, Anja Irmisch, +11 authors, Daniel J Stekhoven. less BMC Med Inform Decis Mak, 2018 Oct 31; 18(1). PMID: 30373609 Free PMC article.
Killer immunoglobulin-like receptor genotype did not correlate with response to anti-PD-1 antibody treatment in a Japanese cohort. Yoshihiro Ishida, Chisa Nakashima, +8 authors, Kenji Kabashima. less Sci Rep, 2018 Oct 31; 8(1). PMID: 30374122 Free PMC article.
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer. Alexandra Thomas, Eric D Routh, +17 authors, Lance D Miller. less Oncoimmunology, 2018 Nov 06; 7(10). PMID: 30386679 Free PMC article. Highly Cited.
Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments. Jong W Yu, Sabyasachi Bhattacharya, +24 authors, Roopa Srinivasan. less PLoS One, 2018 Nov 06; 13(11). PMID: 30388137 Free PMC article.
An assessment of prognostic immunity markers in breast cancer. Benlong Yang, Jeff Chou, +13 authors, Zhiyuan Hu. less NPJ Breast Cancer, 2018 Nov 06; 4. PMID: 30393759 Free PMC article.
Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Silvia C Formenti, Nils-Petter Rudqvist, +15 authors, Sandra Demaria. less Nat Med, 2018 Nov 07; 24(12). PMID: 30397353 Free PMC article. Highly Cited.
Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance. Xingxiang Pu, Lin Wu, +2 authors, Dan Su, Weimin Mao, Bingliang Fang. less BMC Cancer, 2018 Nov 10; 18(1). PMID: 30409126 Free PMC article. Review.
TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure. Ankur Chakravarthy, Lubaba Khan, +2 authors, Nathan Peter Bensler, Pinaki Bose, Daniel D De Carvalho. less Nat Commun, 2018 Nov 10; 9(1). PMID: 30410077 Free PMC article. Highly Cited.
Promising clinical application of ctDNA in evaluating immunotherapy efficacy. Li Li, Jun Zhang, Xiaoyue Jiang, Qin Li. Am J Cancer Res, 2018 Nov 13; 8(10). PMID: 30416847 Free PMC article. Review.
Mismatch repair-based stratification for immune checkpoint blockade therapy. Lihong Zhang, Yang Peng, Guang Peng. Am J Cancer Res, 2018 Nov 13; 8(10). PMID: 30416850 Free PMC article. Review.
The role of autophagy in the treatment of BRAF mutant colorectal carcinomas differs based on microsatellite instability status. Evangelos Koustas, Athanasios G Papavassiliou, Michalis V Karamouzis. PLoS One, 2018 Nov 15; 13(11). PMID: 30427914 Free PMC article.
Genes at the Crossroad of Primary Immunodeficiencies and Cancer. Charlotte Derpoorter, Victoria Bordon, +2 authors, Tim Lammens. less Front Immunol, 2018 Nov 18; 9. PMID: 30443258 Free PMC article. Review.
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Hanghang Zhang, Somnath Pandey, +30 authors, Jean-Pierre J Issa. less Cell, 2018 Nov 21; 175(5). PMID: 30454645 Free PMC article. Highly Cited.
The role of neoantigen in immune checkpoint blockade therapy. Ming Yi, Shuang Qin, +3 authors, Weiheng Zhao, Shengnan Yu, Qian Chu, Kongming Wu. less Exp Hematol Oncol, 2018 Nov 27; 7. PMID: 30473928 Free PMC article. Highly Cited. Review.
Using Frameshift Peptide Arrays for Cancer Neo-Antigens Screening. Jian Zhang, Luhui Shen, Stephen Albert Johnston. Sci Rep, 2018 Nov 28; 8(1). PMID: 30478295 Free PMC article.
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway. Jianqin Lu, Xiangsheng Liu, +6 authors, Andre E Nel. less ACS Nano, 2018 Nov 30; 12(11). PMID: 30481959 Free PMC article.
Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine. Jake R Conway, Eric Kofman, +2 authors, Shirley S Mo, Haitham Elmarakeby, Eliezer Van Allen. less Genome Med, 2018 Dec 01; 10(1). PMID: 30497521 Free PMC article. Review.
Transformation of Old Concepts for a New Era of Cancer Immunotherapy: Cytokine Therapy and Cancer Vaccines as Combination Partners of PD1/PD-L1 Inhibitors. Romualdo Barroso-Sousa, Patrick A Ott. Curr Oncol Rep, 2018 Dec 01; 21(1). PMID: 30498900 Review.
Rejection of immunogenic tumor clones is limited by clonal fraction. Ron S Gejman, Aaron Y Chang, +4 authors, David A Scheinberg. less Elife, 2018 Dec 01; 7. PMID: 30499773 Free PMC article.
Novel immunotherapy approaches to follicular lymphoma. Christopher R Flowers, John P Leonard, Loretta J Nastoupil. Hematology Am Soc Hematol Educ Program, 2018 Dec 07; 2018(1). PMID: 30504310 Free PMC article. Review.
A scalable solution for tumor mutational burden from formalin-fixed, paraffin-embedded samples using the Oncomine Tumor Mutation Load Assay. Ruchi Chaudhary, Luca Quagliata, +7 authors, Fiona Hyland. less Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505706 Free PMC article.
Methods of measurement for tumor mutational burden in tumor tissue. Bárbara Meléndez, Claude Van Campenhout, +3 authors, Nicky D'Haene. less Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505710 Free PMC article. Highly Cited. Review.
Measuring tumor mutation burden in non-small cell lung cancer: tissue versus liquid biopsy. Francesca Fenizia, Raffaella Pasquale, +3 authors, Nicola Normanno. less Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505711 Free PMC article. Review.
Approach to evaluating tumor mutational burden in routine clinical practice. John Truesdell, Vincent A Miller, David Fabrizio. Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505712 Free PMC article. Review.
Implementing tumor mutational burden (TMB) analysis in routine diagnostics-a primer for molecular pathologists and clinicians. Michael Allgäuer, Jan Budczies, +13 authors, Albrecht Stenzinger. less Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505715 Free PMC article. Highly Cited. Review.
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models. Vassilis Genoud, Eliana Marinari, +5 authors, Paul R Walker. less Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524896 Free PMC article.
Trial watch: Peptide-based vaccines in anticancer therapy. Lucillia Bezu, Oliver Kepp, +6 authors, Lorenzo Galluzzi. less Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524907 Free PMC article. Highly Cited. Review.
Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers. Laurence C Menard, Paul Fischer, +8 authors, Steven G Nadler. less Front Immunol, 2018 Dec 12; 9. PMID: 30534127 Free PMC article.
HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy. Tiziana Triulzi, Luca Forte, +6 authors, Elda Tagliabue. less Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546951 Free PMC article.
A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy. Frederick S Varn, Yue Wang, Chao Cheng. Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546953 Free PMC article.
Immunophenotypes of pancreatic ductal adenocarcinoma: Meta-analysis of transcriptional subtypes. Ines de Santiago, Christopher Yau, +5 authors, Shivan Sivakumar. less Int J Cancer, 2019 Feb 06; 145(4). PMID: 30720864 Free PMC article.
Microsatellite instability in endometrial cancer: New purpose for an old test. Katherine C Kurnit, Shannon N Westin, Robert L Coleman. Cancer, 2019 Mar 27; 125(13). PMID: 30913308 Free PMC article.
Targeting immune cells for cancer therapy. Sin Yee Gun, Sharon Wei Ling Lee, Je Lin Sieow, Siew Cheng Wong. Redox Biol, 2019 Mar 29; 25. PMID: 30917934 Free PMC article. Highly Cited. Review.
Bladder cancer, a unique model to understand cancer immunity and develop immunotherapy approaches. Dongkui Song, Thomas Powles, +3 authors, Yong-Jie Lu. less J Pathol, 2019 May 19; 249(2). PMID: 31102277 Free PMC article. Review.
The current state of molecular testing in the treatment of patients with solid tumors, 2019. Wafik S El-Deiry, Richard M Goldberg, +10 authors, John L Marshall. less CA Cancer J Clin, 2019 May 23; 69(4). PMID: 31116423 Free PMC article. Highly Cited. Review.
Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression. Shenying Fang, Tao Xu, +12 authors, Jeffrey E Lee. less J Invest Dermatol, 2019 Jun 10; 139(11). PMID: 31176707 Free PMC article.
Epidemiologic perspectives on immunosuppressed populations and the immunosurveillance and immunocontainment of cancer. Eric A Engels. Am J Transplant, 2019 Jun 18; 19(12). PMID: 31206226 Free PMC article. Review.
Precision neuroradiology: mapping the nodes and networks that link genes to behaviour. Leo P Sugrue, Rahul S Desikan. Br J Radiol, 2019 Jul 12; 92(1101). PMID: 31294609 Free PMC article. Review.
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade. Joseph L Benci, Lexus R Johnson, +14 authors, Andy J Minn. less Cell, 2019 Aug 10; 178(4). PMID: 31398344 Free PMC article. Highly Cited.
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors. Sanjeevani Arora, Rodion Velichinskii, +6 authors, Yanis Boumber. less Adv Ther, 2019 Aug 15; 36(10). PMID: 31410780 Free PMC article. Review.
Novel Biomarkers for Personalized Cancer Immunotherapy. Yoshitaro Shindo, Shoichi Hazama, +2 authors, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano. less Cancers (Basel), 2019 Aug 25; 11(9). PMID: 31443339 Free PMC article. Review.
Programmed Cell Death Ligand 1 in Breast Cancer: Technical Aspects, Prognostic Implications, and Predictive Value. Federica Miglietta, Gaia Griguolo, Valentina Guarneri, Maria Vittoria Dieci. Oncologist, 2019 Aug 25; 24(11). PMID: 31444294 Free PMC article. Review.
The Systemic Treatment of Melanoma. Patrick Terheyden, Angela Krackhardt, Thomas Eigentler. Dtsch Arztebl Int, 2019 Aug 28; 116(29-30). PMID: 31452501 Free PMC article. Review.
Single-Cell Transcriptome Analysis Reveals Gene Signatures Associated with T-cell Persistence Following Adoptive Cell Therapy. Yong-Chen Lu, Li Jia, +3 authors, Steven A Rosenberg. less Cancer Immunol Res, 2019 Sep 06; 7(11). PMID: 31484655 Free PMC article.
Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy. Shixiang Wang, Li An Cowley, Xue-Song Liu. Molecules, 2019 Sep 07; 24(18). PMID: 31487832 Free PMC article. Highly Cited. Review.
Panoptic View of Prognostic Models for Personalized Breast Cancer Management. Geetanjali Saini, Karuna Mittal, +3 authors, Ritu Aneja. less Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500225 Free PMC article. Review.
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma. Yochai Wolf, Osnat Bartok, +26 authors, Yardena Samuels. less Cell, 2019 Sep 17; 179(1). PMID: 31522890 Free PMC article. Highly Cited.
Matched Whole-Genome Sequencing (WGS) and Whole-Exome Sequencing (WES) of Tumor Tissue with Circulating Tumor DNA (ctDNA) Analysis: Complementary Modalities in Clinical Practice. Robin Imperial, Marjan Nazer, +9 authors, Ashiq Masood. less Cancers (Basel), 2019 Sep 25; 11(9). PMID: 31546879 Free PMC article.
Review and perspective on adjuvant and neoadjuvant immunotherapies in NSCLC. Chengxiang Yi, Yayi He, +2 authors, Haoran Xia, Helin Zhang, Peng Zhang. less Onco Targets Ther, 2019 Oct 01; 12. PMID: 31564915 Free PMC article.
Immunotherapy for head and neck cancer: where are we now and where are we going? Joshua M Bauml, Charu Aggarwal, Roger B Cohen. Ann Transl Med, 2019 Oct 03; 7(Suppl 3). PMID: 31576284 Free PMC article.
New insights in predictive determinants of the tumor immune microenvironment for immune checkpoint inhibition: a never ending story? Markus Eckstein, Shilpa Gupta. Ann Transl Med, 2019 Oct 03; 7(Suppl 3). PMID: 31576342 Free PMC article.
Unraveling the Heterogeneous Mutational Signature of Spontaneously Developing Tumors in MLH1-/- Mice. Yvonne Saara Gladbach, Leonie Wiegele, +4 authors, Claudia Maletzki. less Cancers (Basel), 2019 Oct 05; 11(10). PMID: 31581674 Free PMC article.
High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma. Kenneth H Buetow, Lydia R Meador, +6 authors, K Taraszka Hastings. less J Immunol, 2019 Oct 09; 203(10). PMID: 31591149 Free PMC article.
Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens. Bas Weenink, Kaspar Draaisma, +4 authors, Pim J French. less Sci Rep, 2019 Oct 12; 9(1). PMID: 31601888 Free PMC article.
The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T-Cell Repertoire. Shubhankar Nath, Girgis Obaid, Tayyaba Hasan. Photochem Photobiol, 2019 Oct 12; 95(6). PMID: 31602649 Free PMC article. Review.
Lynch syndrome-associated ultra-hypermutated pediatric glioblastoma mimicking a constitutional mismatch repair deficiency syndrome. Chen Yang, Frances Austin, +5 authors, Scott A Turner. less Cold Spring Harb Mol Case Stud, 2019 Oct 13; 5(5). PMID: 31604779 Free PMC article.
Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade. Lee P Richman, Robert H Vonderheide, Andrew J Rech. Cell Syst, 2019 Oct 14; 9(4). PMID: 31606370 Free PMC article.
Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes. Alena Gros, Eric Tran, +15 authors, Steven A Rosenberg. less J Clin Invest, 2019 Oct 15; 129(11). PMID: 31609250 Free PMC article.
Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers. Hao-Xiang Wu, Yan-Xing Chen, +5 authors, Rui-Hua Xu. less J Immunother Cancer, 2019 Oct 19; 7(1). PMID: 31623662 Free PMC article.
Blood tumor mutational burden: are we ready for clinical implementation? Claude Van Campenhout, Bárbara Meléndez, +2 authors, Myriam Remmelink, Isabelle Salmon, Nicky D'Haene. less J Thorac Dis, 2019 Oct 22; 11(Suppl 15). PMID: 31632782 Free PMC article.
MHC-II neoantigens shape tumour immunity and response to immunotherapy. Elise Alspach, Danielle M Lussier, +20 authors, Robert D Schreiber. less Nature, 2019 Oct 28; 574(7780). PMID: 31645760 Free PMC article. Highly Cited.
Clinicopathological correlation of immune response in human cancers. Yuexin Liu. Oncotarget, 2019 Oct 28; 10(56). PMID: 31645905 Free PMC article.
Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion. Reshmi Tripathi, Vishnu Modur, +2 authors, Laura Senovilla, Guido Kroemer, Kakajan Komurov. less Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646083 Free PMC article.
Prognostic impact of the Controlling Nutritional Status score in patients with non-small cell lung cancer treated with pembrolizumab. Taro Ohba, Shinkichi Takamori, +9 authors, Mitsuhiro Takenoyama. less J Thorac Dis, 2019 Oct 28; 11(9). PMID: 31656648 Free PMC article.
Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives. E Krasniqi, G Barchiesi, +17 authors, P Vici. less J Hematol Oncol, 2019 Oct 31; 12(1). PMID: 31665051 Free PMC article. Review.
pTuneos: prioritizing tumor neoantigens from next-generation sequencing data. Chi Zhou, Zhiting Wei, +8 authors, Qi Liu. less Genome Med, 2019 Nov 02; 11(1). PMID: 31666118 Free PMC article.
Safety and Efficacy of Therapeutic Cancer Vaccines Alone or in Combination With Immune Checkpoint Inhibitors in Cancer Treatment. Jing Zhao, Ye Chen, Zhen-Yu Ding, Ji-Yan Liu. Front Pharmacol, 2019 Nov 05; 10. PMID: 31680963 Free PMC article. Review.
Endogenous T cells prevent tumor immune escape following adoptive T cell therapy. Scott R Walsh, Boris Simovic, +7 authors, Yonghong Wan. less J Clin Invest, 2019 Nov 05; 129(12). PMID: 31682239 Free PMC article.
Significant response to anti-PD-1 based immunotherapy plus lenvatinib for recurrent intrahepatic cholangiocarcinoma with bone metastasis: A case report and literature review. Wei-Xun Chen, Gan-Xun Li, +3 authors, Ze-Yang Ding. less Medicine (Baltimore), 2019 Nov 09; 98(45). PMID: 31702638 Free PMC article. Review.
Immune checkpoint inhibitor-associated gastrointestinal and hepatic adverse events and their management. Uday N Shivaji, Louisa Jeffery, +5 authors, Marietta Iacucci. less Therap Adv Gastroenterol, 2019 Nov 15; 12. PMID: 31723355 Free PMC article. Review.
Immune Checkpoint Inhibition in Hodgkin Lymphoma. Ryan H Moy, Anas Younes. Hemasphere, 2018 Feb 16; 2(1). PMID: 31723749 Free PMC article. Review.
DeepHLApan: A Deep Learning Approach for Neoantigen Prediction Considering Both HLA-Peptide Binding and Immunogenicity. Jingcheng Wu, Wenzhe Wang, +7 authors, Shuqing Chen. less Front Immunol, 2019 Nov 19; 10. PMID: 31736974 Free PMC article.
The Predictive Value of Tumor Mutation Burden on Efficacy of Immune Checkpoint Inhibitors in Cancers: A Systematic Review and Meta-Analysis. Yongfeng Wu, Jinming Xu, +4 authors, Jian Hu. less Front Oncol, 2019 Nov 22; 9. PMID: 31750249 Free PMC article. Systematic Review.
Tumor mutational burden in lung cancer: a systematic literature review. Connor Willis, Michelle Fiander, +6 authors, David D Stenehjem. less Oncotarget, 2019 Nov 26; 10(61). PMID: 31762941 Free PMC article. Review.
Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction. Shixiang Wang, Zaoke He, +2 authors, Xuan Wang, Huimin Li, Xue-Song Liu. less Elife, 2019 Nov 27; 8. PMID: 31767055 Free PMC article.
Lack of detectable neoantigen depletion signals in the untreated cancer genome. Jimmy Van den Eynden, Alejandro Jiménez-Sánchez, Martin L Miller, Erik Larsson. Nat Genet, 2019 Nov 27; 51(12). PMID: 31768072 Free PMC article.
Prostate Cancer Screening and Management in Solid Organ Transplant Candidates and Recipients. Ezequiel Becher, Alex Wang, Herbert Lepor. Rev Urol, 2019 Nov 27; 21(2-3). PMID: 31768135 Free PMC article.
Machine Learning for Cancer Immunotherapies Based on Epitope Recognition by T Cell Receptors. Anja Mösch, Silke Raffegerst, +2 authors, Manon Weis, Dolores J Schendel, Dmitrij Frishman. less Front Genet, 2019 Dec 05; 10. PMID: 31798635 Free PMC article. Review.
Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor. Xianguang Bai, Ming Yi, +2 authors, Ying Jiao, Qian Chu, Kongming Wu. less Onco Targets Ther, 2019 Dec 07; 12. PMID: 31807028 Free PMC article. Review.
Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response. Elaine R Mardis. Genome Med, 2019 Nov 22; 11(1). PMID: 31747945 Free PMC article. Review.
Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic Implications. Matthew J Ryan, Rohit Bose. Front Oncol, 2019 Dec 12; 9. PMID: 31824860 Free PMC article. Review.
Survival correlation of immune response in human cancers. Yuexin Liu. Oncotarget, 2019 Dec 17; 10(64). PMID: 31839882 Free PMC article.
Neoantigen Fitness Model Predicts Lower Immune Recognition of Cutaneous Squamous Cell Carcinomas Than Actinic Keratoses. Elizabeth S Borden, Paul Kang, +4 authors, Karen Taraszka Hastings. less Front Immunol, 2019 Dec 19; 10. PMID: 31849976 Free PMC article.
Genetic instability as a driver for immune surveillance. Guim Aguadé-Gorgorió, Ricard Solé. J Immunother Cancer, 2019 Dec 13; 7(1). PMID: 31829285 Free PMC article.
Immunotherapy for acute myeloid leukemia: from allogeneic stem cell transplant to novel therapeutics. David A Knorr, Aaron D Goldberg, Eytan M Stein, Martin S Tallman. Leuk Lymphoma, 2019 Jul 25; 60(14). PMID: 31335250 Free PMC article. Review.
Comprehensive Outline of Whole Exome Sequencing Data Analysis Tools Available in Clinical Oncology. Áron Bartha, Balázs Győrffy. Cancers (Basel), 2019 Nov 07; 11(11). PMID: 31690036 Free PMC article. Review.
Tumor Mutational Burden and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis. Jong Yeob Kim, Andreas Kronbichler, +5 authors, Gabriele Gamerith. less Cancers (Basel), 2019 Nov 17; 11(11). PMID: 31731749 Free PMC article.
Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer. Natalie I Vokes, David Liu, +19 authors, Mark M Awad. less JCO Precis Oncol, 2019 Dec 14; 3. PMID: 31832578 Free PMC article.
The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies. Kroopa Joshi, Benjamin M Chain, Karl S Peggs, Sergio A Quezada. Cold Spring Harb Perspect Med, 2017 Jun 21; 8(1). PMID: 28630228 Free PMC article. Review.
Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4. Jitske van den Bulk, Els M E Verdegaal, +12 authors, Noel F C C de Miranda. less Genome Med, 2020 Jan 01; 11(1). PMID: 31888734 Free PMC article.
Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors. Wenyan Zhong, Jeremy S Myers, +11 authors, Paul A Rejto. less BMC Genomics, 2020 Jan 04; 21(1). PMID: 31898484 Free PMC article.
Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies. Shetal A Patel, Andy J Minn. Immunity, 2018 Mar 22; 48(3). PMID: 29562193 Free PMC article. Highly Cited. Review.
Innovation in Oncology Drug Development. Matthew Huber, Brian Huber. J Oncol, 2020 Jan 09; 2019. PMID: 31911803 Free PMC article. Review.
Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display. Stina L Wickström, Tanja Lövgren, +14 authors, Rolf Kiessling. less Front Immunol, 2020 Jan 11; 10. PMID: 31921104 Free PMC article.
Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Rα Complexes Enhances Tumor Control. Emilio Sanseviero, Erin M O'Brien, +16 authors, Erica L Stone. less Cancer Immunol Res, 2019 Jun 27; 7(8). PMID: 31239316 Free PMC article.
Molecular profiling for precision cancer therapies. Eoghan R Malone, Marc Oliva, +2 authors, Peter J B Sabatini, Tracy L Stockley, Lillian L Siu. less Genome Med, 2020 Jan 16; 12(1). PMID: 31937368 Free PMC article. Review.
An Exon Signature to Estimate the Tumor Mutational Burden of Right-sided Colon Cancer Patients. Wenbing Guo, Yelin Fu, +7 authors, Zheng Guo. less J Cancer, 2020 Jan 18; 11(4). PMID: 31949492 Free PMC article.
Tumor Mutational Burden as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors: A Review of Current Evidence. Samuel J Klempner, David Fabrizio, +8 authors, Prasanth Reddy. less Oncologist, 2019 Oct 04; 25(1). PMID: 31578273 Free PMC article. Review.
Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next-Generation Sequencing-Based Multiplex Gene Panel Assay. Pham Nguyen Quy, Masashi Kanai, +16 authors, Manabu Muto. less Oncologist, 2019 Jun 13; 24(12). PMID: 31186376 Free PMC article.
pMHC Structural Comparisons as a Pivotal Element to Detect and Validate T-Cell Targets for Vaccine Development and Immunotherapy-A New Methodological Proposal. Priscila Vianna, Marcus F A Mendes, +4 authors, Gustavo F Vieira. less Cells, 2019 Nov 27; 8(12). PMID: 31766602 Free PMC article.
Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma. Deepak Perumal, Naoko Imai, +14 authors, Samir Parekh. less Clin Cancer Res, 2019 Dec 21; 26(2). PMID: 31857430 Free PMC article.
Rationale of Immunotherapy in Hepatocellular Carcinoma and Its Potential Biomarkers. David Tai, Su Pin Choo, Valerie Chew. Cancers (Basel), 2019 Dec 11; 11(12). PMID: 31816940 Free PMC article. Review.
Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer. Jenna H Newman, C Brent Chesson, +45 authors, Andrew Zloza. less Proc Natl Acad Sci U S A, 2020 Jan 01; 117(2). PMID: 31888983 Free PMC article.
Biomarkers Predictive of Survival and Response to Immune Checkpoint Inhibitors in Melanoma. Emanuelle M Rizk, Angelina M Seffens, +5 authors, Yvonne M Saenger. less Am J Clin Dermatol, 2019 Oct 12; 21(1). PMID: 31602560 Free PMC article. Review.
Identification of a CD8+ T-cell response to a predicted neoantigen in malignant mesothelioma. Sophie Sneddon, Craig M Rive, +9 authors, Jenette Creaney. less Oncoimmunology, 2020 Feb 01; 9(1). PMID: 32002298 Free PMC article.
Pre-treatment tumor neo-antigen responses in draining lymph nodes are infrequent but predict checkpoint blockade therapy outcome. Shaokang Ma, Jonathan Chee, +5 authors, Jenette Creaney. less Oncoimmunology, 2020 Feb 01; 9(1). PMID: 32002299 Free PMC article.
Targeted literature review on use of tumor mutational burden status and programmed cell death ligand 1 expression to predict outcomes of checkpoint inhibitor treatment. Tina Krieger, Isobel Pearson, +2 authors, Judith Bell, Jim Doherty, Paul Robbins. less Diagn Pathol, 2020 Feb 01; 15(1). PMID: 32000815 Free PMC article. Review.
Comprehensive T cell repertoire characterization of non-small cell lung cancer. Alexandre Reuben, Jiexin Zhang, +55 authors, Jianjun Zhang. less Nat Commun, 2020 Feb 01; 11(1). PMID: 32001676 Free PMC article.
High Somatic Mutation and Neoantigen Burden Do Not Correlate with Decreased Progression-Free Survival in HCC Patients not Undergoing Immunotherapy. Angela Mauriello, Roberta Zeuli, +6 authors, Luigi Buonaguro. less Cancers (Basel), 2019 Nov 24; 11(12). PMID: 31756926 Free PMC article.
Promising Colorectal Cancer Biomarkers for Precision Prevention and Therapy. Mimmo Turano, Paolo Delrio, +5 authors, Marina De Rosa. less Cancers (Basel), 2019 Dec 11; 11(12). PMID: 31817090 Free PMC article. Review.
Tumor immune response and immunotherapy in gastric cancer. Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee. J Pathol Transl Med, 2019 Nov 02; 54(1). PMID: 31674166 Free PMC article. Review.
Oncogene addiction and tumor mutational burden in non-small-cell lung cancer: Clinical significance and limitations. Elisabeth Smolle, Katharina Leithner, Horst Olschewski. Thorac Cancer, 2019 Dec 05; 11(2). PMID: 31799812 Free PMC article. Review.
Gut Microbiome as a Potential Factor for Modulating Resistance to Cancer Immunotherapy. Lin Shui, Xi Yang, +3 authors, Jian Li, Cheng Yi, Qin Sun, Hong Zhu. less Front Immunol, 2020 Feb 06; 10. PMID: 32010123 Free PMC article. Review.
Neoantigens from the bench to the bedside: new prospective for ovarian cancer immunotherapy. Chiara Napoletano, Filippo Bellati. Ann Transl Med, 2020 Feb 06; 7(Suppl 8). PMID: 32016024 Free PMC article.
Mutated RAS: Targeting the "Untargetable" with T Cells. Praveen D Chatani, James C Yang. Clin Cancer Res, 2019 Sep 13; 26(3). PMID: 31511296 Free PMC article. Review.
Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade. Julie E Stein, Evan J Lipson, +12 authors, Janis M Taube. less Clin Cancer Res, 2019 Nov 02; 26(3). PMID: 31672770 Free PMC article.
Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K BRAF-Mutant Melanoma. Inês Pires da Silva, Kevin Y X Wang, +16 authors, Alexander M Menzies. less Clin Cancer Res, 2019 Jan 12; 25(4). PMID: 30630828 Free PMC article.
Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies. Hongxing Shen, Eddy Shih-Hsin Yang, +4 authors, Lewis Zhichang Shi. less Genes Dis, 2020 Feb 12; 6(3). PMID: 32042863 Free PMC article. Review.
Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses. Anthony E Zamora, Jeremy Chase Crawford, +17 authors, Paul G Thomas. less Sci Transl Med, 2019 Jun 28; 11(498). PMID: 31243155 Free PMC article.
Advancing Biomarker Development Through Convergent Engagement: Summary Report of the 2nd International Danube Symposium on Biomarker Development, Molecular Imaging and Applied Diagnostics; March 14-16, 2018; Vienna, Austria. M S Lim, Thomas Beyer, +25 authors, M Hacker. less Mol Imaging Biol, 2019 May 03; 22(1). PMID: 31049831
Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML. Fabiana Perna, Samuel H Berman, +6 authors, Michel Sadelain. less Cancer Cell, 2017 Oct 11; 32(4). PMID: 29017060 Free PMC article. Highly Cited.

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