Journal Article
. 2014 Nov; 371(23):2189-2199.
doi: 10.1056/NEJMoa1406498.

Genetic basis for clinical response to CTLA-4 blockade in melanoma

Alexandra Snyder 1 Vladimir Makarov 1 Taha Merghoub 1 Jianda Yuan 1 Jesse M Zaretsky 1 Alexis Desrichard 1 Logan A Walsh 1 Michael A Postow 1 Phillip Wong 1 Teresa S Ho 1 Travis J Hollmann 1 Cameron Bruggeman 1 Kasthuri Kannan 1 Yanyun Li 1 Ceyhan Elipenahli 1 Cailian Liu 1 Christopher T Harbison 1 Lisu Wang 1 Antoni Ribas 1 Jedd D Wolchok 1 Timothy A Chan 1 
  • PMID: 25409260
  •     36 References
  •     1813 citations


Background: Immune checkpoint inhibitors are effective cancer treatments, but molecular determinants of clinical benefit are unknown. Ipilimumab and tremelimumab are antibodies against cytotoxic T-lymphocyte antigen 4 (CTLA-4). Anti-CTLA-4 treatment prolongs overall survival in patients with melanoma. CTLA-4 blockade activates T cells and enables them to destroy tumor cells.

Methods: We obtained tumor tissue from patients with melanoma who were treated with ipilimumab or tremelimumab. Whole-exome sequencing was performed on tumors and matched blood samples. Somatic mutations and candidate neoantigens generated from these mutations were characterized. Neoantigen peptides were tested for the ability to activate lymphocytes from ipilimumab-treated patients.

Results: Malignant melanoma exomes from 64 patients treated with CTLA-4 blockade were characterized with the use of massively parallel sequencing. A discovery set consisted of 11 patients who derived a long-term clinical benefit and 14 patients who derived a minimal benefit or no benefit. Mutational load was associated with the degree of clinical benefit (P=0.01) but alone was not sufficient to predict benefit. Using genomewide somatic neoepitope analysis and patient-specific HLA typing, we identified candidate tumor neoantigens for each patient. We elucidated a neoantigen landscape that is specifically present in tumors with a strong response to CTLA-4 blockade. We validated this signature in a second set of 39 patients with melanoma who were treated with anti-CTLA-4 antibodies. Predicted neoantigens activated T cells from the patients treated with ipilimumab.

Conclusions: These findings define a genetic basis for benefit from CTLA-4 blockade in melanoma and provide a rationale for examining exomes of patients for whom anti-CTLA-4 agents are being considered. (Funded by the Frederick Adler Fund and others.).

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Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints.
Niki Karachaliou, Maria Gonzalez Cao, +4 authors, Rafael Rosell.
Cancer Biol Med, 2015 Jul 16; 12(2). PMID: 26175923    Free PMC article.
Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights.
Alexander Faje.
Pituitary, 2015 Jul 19; 19(1). PMID: 26186958
Highly Cited. Review.
Precision medicine for metastatic breast cancer--limitations and solutions.
Monica Arnedos, Cecile Vicier, +4 authors, Fabrice Andre.
Nat Rev Clin Oncol, 2015 Jul 22; 12(12). PMID: 26196250
Highly Cited. Review.
Update on checkpoint blockade therapy for lymphoma.
Justin Kline, Michael R Bishop.
J Immunother Cancer, 2015 Jul 23; 3. PMID: 26199729    Free PMC article.
Evolving synergistic combinations of targeted immunotherapies to combat cancer.
Ignacio Melero, David M Berman, +3 authors, John Haanen.
Nat Rev Cancer, 2015 Jul 25; 15(8). PMID: 26205340
Highly Cited. Review.
Therapeutic cancer vaccines.
Cornelis J M Melief, Thorbald van Hall, +2 authors, Sjoerd H van der Burg.
J Clin Invest, 2015 Jul 28; 125(9). PMID: 26214521    Free PMC article.
Highly Cited. Review.
Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment.
J David Peske, Amber B Woods, Victor H Engelhard.
Adv Cancer Res, 2015 Jul 29; 128. PMID: 26216636    Free PMC article.
Combined Trabectedin and anti-PD1 antibody produces a synergistic antitumor effect in a murine model of ovarian cancer.
Zhiqiang Guo, Haolin Wang, +2 authors, Shulan Zhang.
J Transl Med, 2015 Jul 30; 13. PMID: 26219551    Free PMC article.
Origins, genetic landscape, and emerging therapies of small cell lung cancer.
Ekaterina A Semenova, Remco Nagel, Anton Berns.
Genes Dev, 2015 Jul 30; 29(14). PMID: 26220992    Free PMC article.
Highly Cited. Review.
Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine.
Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong.
Yonsei Med J, 2015 Aug 11; 56(5). PMID: 26256958    Free PMC article.
Tumor neoantigens: building a framework for personalized cancer immunotherapy.
Matthew M Gubin, Maxim N Artyomov, Elaine R Mardis, Robert D Schreiber.
J Clin Invest, 2015 Aug 11; 125(9). PMID: 26258412    Free PMC article.
Highly Cited. Review.
Genomic spectra of biliary tract cancer.
Hiromi Nakamura, Yasuhito Arai, +14 authors, Tatsuhiro Shibata.
Nat Genet, 2015 Aug 11; 47(9). PMID: 26258846
Highly Cited.
An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.
Kin Chan, Steven A Roberts, +9 authors, Dmitry A Gordenin.
Nat Genet, 2015 Aug 11; 47(9). PMID: 26258849    Free PMC article.
Highly Cited.
Prospects of immune checkpoint modulators in the treatment of glioblastoma.
Matthias Preusser, Michael Lim, +2 authors, John H Sampson.
Nat Rev Neurol, 2015 Aug 12; 11(9). PMID: 26260659    Free PMC article.
Highly Cited. Review.
Gender Disparity and Mutation Burden in Metastatic Melanoma.
Sameer Gupta, Mykyta Artomov, +2 authors, Hensin Tsao.
J Natl Cancer Inst, 2015 Aug 25; 107(11). PMID: 26296643    Free PMC article.
Immunotherapy of Childhood Sarcomas.
Stephen S Roberts, Alexander J Chou, Nai-Kong V Cheung.
Front Oncol, 2015 Aug 25; 5. PMID: 26301204    Free PMC article.
Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes.
Feixiong Cheng, Junfei Zhao, Zhongming Zhao.
Brief Bioinform, 2015 Aug 27; 17(4). PMID: 26307061    Free PMC article.
Tumor infiltrating lymphocyte therapy for ovarian cancer and renal cell carcinoma.
Rikke Andersen, Marco Donia, +3 authors, Inge Marie Svane.
Hum Vaccin Immunother, 2015 Aug 27; 11(12). PMID: 26308285    Free PMC article.
Strategies for combining immunotherapy with radiation for anticancer therapy.
Steven N Seyedin, Jonathan E Schoenhals, +14 authors, James W Welsh.
Immunotherapy, 2015 Aug 28; 7(9). PMID: 26310908    Free PMC article.
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
Katherine B Chiappinelli, Pamela L Strissel, +20 authors, Reiner Strick.
Cell, 2015 Sep 01; 162(5). PMID: 26317466    Free PMC article.
Highly Cited.
Antagonists of PD-1 and PD-L1 in Cancer Treatment.
Evan J Lipson, Patrick M Forde, +3 authors, Suzanne L Topalian.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320063    Free PMC article.
Highly Cited. Review.
The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment.
Thomas F Gajewski.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320069    Free PMC article.
Highly Cited. Review.
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.
Xiaojuan Liu, Yang Pu, +7 authors, Meng Michelle Xu.
Nat Med, 2015 Sep 01; 21(10). PMID: 26322579    Free PMC article.
Highly Cited.
Oncolytic viruses: a new class of immunotherapy drugs.
Howard L Kaufman, Frederick J Kohlhapp, Andrew Zloza.
Nat Rev Drug Discov, 2015 Sep 02; 14(9). PMID: 26323545    Free PMC article.
Highly Cited. Review.
Immunity, inflammation, and cancer: an eternal fight between good and evil.
Shabnam Shalapour, Michael Karin.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325032    Free PMC article.
Highly Cited. Review.
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade.
Elizabeth Buchbinder, F Stephen Hodi.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325034    Free PMC article.
Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures.
Soraya Curiel-Olmo, Almudena García-Castaño, +17 authors, José Vaqué.
Oncotarget, 2015 Sep 04; 6(28). PMID: 26327537    Free PMC article.
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis.
Anne Bertrand, Marie Kostine, +2 authors, Thierry Schaeverbeke.
BMC Med, 2015 Sep 05; 13. PMID: 26337719    Free PMC article.
Highly Cited. Systematic Review.
A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme.
Gilli Galore-Haskel, Yael Nemlich, +11 authors, Gal Markel.
Oncotarget, 2015 Sep 05; 6(30). PMID: 26338962    Free PMC article.
Germline determinants of clinical outcome of cutaneous melanoma.
Matjaz Vogelsang, Melissa Wilson, Tomas Kirchhoff.
Pigment Cell Melanoma Res, 2015 Sep 06; 29(1). PMID: 26342156    Free PMC article.
Integrating Immune Checkpoint Blockade with Anti-Neo/Mutated Antigens Reactivity to Increase the Clinical Outcome of Immunotherapy.
Giorgio Parmiani, Cristina Maccalli, Michele Maio.
Vaccines (Basel), 2015 Sep 08; 3(2). PMID: 26343195    Free PMC article.
The Promise of Preventive Cancer Vaccines.
Pier-Luigi Lollini, Federica Cavallo, Patrizia Nanni, Elena Quaglino.
Vaccines (Basel), 2015 Sep 08; 3(2). PMID: 26343198    Free PMC article.
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
A Hunter Shain, Maria Garrido, +20 authors, Boris C Bastian.
Nat Genet, 2015 Sep 08; 47(10). PMID: 26343386    Free PMC article.
Highly Cited.
Interest of Tumor-Specific CD4 T Helper 1 Cells for Therapeutic Anticancer Vaccine.
Jeanne Galaine, Christophe Borg, Yann Godet, Olivier Adotévi.
Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350591    Free PMC article.
Systems Biology Approach for Cancer Vaccine Development and Evaluation.
Luisa Circelli, Annacarmen Petrizzo, +3 authors, Luigi Buonaguro.
Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350594    Free PMC article.
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.
Eliezer M Van Allen, Diana Miao, +19 authors, Levi A Garraway.
Science, 2015 Sep 12; 350(6257). PMID: 26359337    Free PMC article.
Highly Cited.
Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth.
Sonja Kleffel, Christian Posch, +19 authors, Tobias Schatton.
Cell, 2015 Sep 12; 162(6). PMID: 26359984    Free PMC article.
Highly Cited.
Long term survival with cytotoxic T lymphocyte-associated antigen 4 blockade using tremelimumab.
Zeynep Eroglu, Dae Won Kim, +9 authors, Antoni Ribas.
Eur J Cancer, 2015 Sep 15; 51(17). PMID: 26364516    Free PMC article.
Targeting the undruggable: immunotherapy meets personalized oncology in the genomic era.
S D Martin, G Coukos, R A Holt, B H Nelson.
Ann Oncol, 2015 Sep 16; 26(12). PMID: 26371284    Free PMC article.
Immunotherapies for bladder cancer: a new hope.
Farhad Fakhrejahani, Yusuke Tomita, +3 authors, Andrea B Apolo.
Curr Opin Urol, 2015 Sep 16; 25(6). PMID: 26372038    Free PMC article.
Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.
Luke S Manlove, Katherine E Berquam-Vrieze, +3 authors, Michael A Farrar.
J Immunol, 2015 Sep 18; 195(8). PMID: 26378075    Free PMC article.
Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma.
Ahmad A Tarhini, Haris Zahoor, +4 authors, John M Kirkwood.
J Immunother Cancer, 2015 Sep 18; 3. PMID: 26380086    Free PMC article.
Highly Cited.
Multiple structural and epigenetic defects in the human leukocyte antigen class I antigen presentation pathway in a recurrent metastatic melanoma following immunotherapy.
Chien-Chung Chang, Giuseppe Pirozzi, +6 authors, Soldano Ferrone.
J Biol Chem, 2015 Sep 19; 290(44). PMID: 26381407    Free PMC article.
Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes.
Cyrille J Cohen, Jared J Gartner, +11 authors, Paul F Robbins.
J Clin Invest, 2015 Sep 22; 125(10). PMID: 26389673    Free PMC article.
Highly Cited.
Nivolumab in combination with ipilimumab for the treatment of melanoma.
Rajasekharan Somasundaram, Meenhard Herlyn.
Expert Rev Anticancer Ther, 2015 Sep 25; 15(10). PMID: 26402246    Free PMC article.
Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology.
Sandip P Patel, Maria Schwaederle, +10 authors, Razelle Kurzrock.
Oncotarget, 2015 Sep 30; 6(32). PMID: 26418953    Free PMC article.
MicroRNA MIR21 and T Cells in Colorectal Cancer.
Kosuke Mima, Reiko Nishihara, +20 authors, Shuji Ogino.
Cancer Immunol Res, 2015 Oct 01; 4(1). PMID: 26419959    Free PMC article.
The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers.
Brandon Leonard, Jennifer L McCann, +8 authors, Reuben S Harris.
Cancer Res, 2015 Oct 01; 75(21). PMID: 26420215    Free PMC article.
Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer.
Guido Giordano, Antonio Febbraro, +13 authors, Massimo Pancione.
J Exp Clin Cancer Res, 2015 Oct 03; 34. PMID: 26427914    Free PMC article.
AACR Cancer Progress Report 2015.
José Baselga, Nina Bhardwaj, +11 authors, Eva Szabo.
Clin Cancer Res, 2015 Oct 03; 21(19 Suppl). PMID: 26429991    Free PMC article.
TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst.
Clemens Hermann, Andy van Hateren, +7 authors, Louise H Boyle.
Elife, 2015 Oct 07; 4. PMID: 26439010    Free PMC article.
Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice.
Luís Felipe Campesato, Romualdo Barroso-Sousa, +6 authors, Anamaria A Camargo.
Oncotarget, 2015 Oct 07; 6(33). PMID: 26439694    Free PMC article.
Highly Cited.
Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients.
Aljosja Rogiers, Joost J van den Oord, +5 authors, Pascal Wolter.
Drugs Aging, 2015 Oct 08; 32(10). PMID: 26442859
Genetics and immunology: reinvigorated.
Alexandra Snyder, Vladimir Makarov, +4 authors, Timothy A Chan.
Oncoimmunology, 2015 Oct 10; 4(10). PMID: 26451299    Free PMC article.
The influence of subclonal resistance mutations on targeted cancer therapy.
Michael W Schmitt, Lawrence A Loeb, Jesse J Salk.
Nat Rev Clin Oncol, 2015 Oct 21; 13(6). PMID: 26483300    Free PMC article.
Highly Cited. Review.
The melanoma-specific graded prognostic assessment does not adequately discriminate prognosis in a modern population with brain metastases from malignant melanoma.
Anna Wilkins, Andrew Furness, +6 authors, Kevin Harrington.
Br J Cancer, 2015 Oct 21; 113(9). PMID: 26484413    Free PMC article.
Immunological landscape and immunotherapy of hepatocellular carcinoma.
Jesús Prieto, Ignacio Melero, Bruno Sangro.
Nat Rev Gastroenterol Hepatol, 2015 Oct 21; 12(12). PMID: 26484443
Highly Cited. Review.
Predictive factors for immunotherapy in melanoma.
Cristina Teixidó, Maria González-Cao, Niki Karachaliou, Rafael Rosell.
Ann Transl Med, 2015 Oct 22; 3(15). PMID: 26488004    Free PMC article.
Functional and genetic deconstruction of the cellular origin in liver cancer.
Jens U Marquardt, Jesper B Andersen, Snorri S Thorgeirsson.
Nat Rev Cancer, 2015 Oct 24; 15(11). PMID: 26493646
Highly Cited. Review.
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
David D Bowtell, Steffen Böhm, +38 authors, Frances R Balkwill.
Nat Rev Cancer, 2015 Oct 24; 15(11). PMID: 26493647    Free PMC article.
Highly Cited. Review.
Molecular Dimensions of Gastric Cancer: Translational and Clinical Perspectives.
Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong.
J Pathol Transl Med, 2015 Oct 27; 50(1). PMID: 26498010    Free PMC article.
Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy.
Kelly Kersten, Camilla Salvagno, Karin E de Visser.
Front Immunol, 2015 Oct 27; 6. PMID: 26500653    Free PMC article.
Clinical Neuropathology mini-review 6-2015: PD-L1: emerging biomarker in glioblastoma?
Matthias Preusser, Anna S Berghoff, Wolfgang Wick, Michael Weller.
Clin Neuropathol, 2015 Oct 27; 34(6). PMID: 26501438    Free PMC article.
Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing.
Mark Klinger, Francois Pepin, +5 authors, Malek Faham.
PLoS One, 2015 Oct 29; 10(10). PMID: 26509579    Free PMC article.
Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy.
David A Reardon, Mark R Gilbert, Wolfgang Wick, Linda Liau.
Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516225    Free PMC article.
Mutational profiling of colorectal cancers with microsatellite instability.
Elaine I Lin, Li-Hui Tseng, +4 authors, James R Eshleman.
Oncotarget, 2015 Oct 31; 6(39). PMID: 26517354    Free PMC article.
Novel immunotherapies in lymphoid malignancies.
Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes.
Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683    Free PMC article.
Highly Cited. Review.
Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.
Jianbin Wang, Joshua J DeClercq, +5 authors, Michael C Holmes.
Nucleic Acids Res, 2015 Nov 04; 44(3). PMID: 26527725    Free PMC article.
Phase I Clinical Trial of Ipilimumab in Pediatric Patients with Advanced Solid Tumors.
Melinda S Merchant, Matthew Wright, +9 authors, Crystal L Mackall.
Clin Cancer Res, 2015 Nov 05; 22(6). PMID: 26534966    Free PMC article.
Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors?
Andy Yingjie Lin, Edward Lin.
J Hematol Oncol, 2015 Nov 07; 8. PMID: 26542241    Free PMC article.
DNA methylation subgroups in melanoma are associated with proliferative and immunological processes.
Martin Lauss, Markus Ringnér, +6 authors, Göran Jönsson.
BMC Med Genomics, 2015 Nov 08; 8. PMID: 26545983    Free PMC article.
Cancer immunotherapy: Strategies for personalization and combinatorial approaches.
Vishwanath Sathyanarayanan, Sattva S Neelapu.
Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548534    Free PMC article.
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition.
Elizabeth I Buchbinder, Anupam Desai.
Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876    Free PMC article.
Highly Cited. Review.
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors.
Karishma R Rajani, Richard G Vile.
Viruses, 2015 Nov 19; 7(11). PMID: 26580645    Free PMC article.
Immunogenomics: a foundation for intelligent immune design.
Robert A Holt.
Genome Med, 2015 Nov 20; 7(1). PMID: 26582413    Free PMC article.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Jelle Scholtalbers, Sebastian Boegel, +6 authors, John C Castle.
Genome Med, 2015 Nov 22; 7. PMID: 26589293    Free PMC article.
Landscape of Tumor Antigens in T Cell Immunotherapy.
Sadia Ilyas, James C Yang.
J Immunol, 2015 Nov 22; 195(11). PMID: 26589749    Free PMC article.
Engineering opportunities in cancer immunotherapy.
Laura Jeanbart, Melody A Swartz.
Proc Natl Acad Sci U S A, 2015 Nov 26; 112(47). PMID: 26598681    Free PMC article.
Combination cancer immunotherapies tailored to the tumour microenvironment.
Mark J Smyth, Shin Foong Ngiow, Antoni Ribas, Michele W L Teng.
Nat Rev Clin Oncol, 2015 Nov 26; 13(3). PMID: 26598942
Highly Cited. Review.
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.
Madhav D Sharma, Rahul Shinde, +12 authors, David H Munn.
Sci Adv, 2015 Nov 26; 1(10). PMID: 26601142    Free PMC article.
Highly Cited.
Immune checkpoint inhibitors: therapeutic advances in melanoma.
Ivan Márquez-Rodas, Pablo Cerezuela, +4 authors, Salvador Martín-Algarra.
Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605313    Free PMC article.
Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells.
David A Quigley, Vessela Kristensen.
Mol Oncol, 2015 Nov 27; 9(10). PMID: 26607741    Free PMC article.
Precision Medicine for Molecularly Targeted Agents and Immunotherapies in Early-Phase Clinical Trials.
Juanita Lopez, Sam Harris, Desam Roda, Timothy A Yap.
Transl Oncogenomics, 2015 Nov 27; 7(Suppl 1). PMID: 26609214    Free PMC article.
Immune suppressive mechanisms in the tumor microenvironment.
David H Munn, Vincenzo Bronte.
Curr Opin Immunol, 2015 Nov 27; 39. PMID: 26609943    Free PMC article.
Highly Cited. Review.
Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014.
Paolo A Ascierto, Michael Atkins, +34 authors, Magdalena Thurin.
J Transl Med, 2015 Dec 02; 13. PMID: 26619946    Free PMC article.
Future directions in the treatment of osteosarcoma.
Michael W Bishop, Katherine A Janeway, Richard Gorlick.
Curr Opin Pediatr, 2015 Dec 03; 28(1). PMID: 26626558    Free PMC article.
Highly Cited. Review.
Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer.
David M Langenau, Alejandro Sweet-Cordero, Robert Wechsler-Reya, Michael A Dyer.
Cancer Res, 2015 Dec 03; 75(24). PMID: 26627009    Free PMC article.
Novel therapies in small cell lung cancer.
Hirva Mamdani, Raghava Induru, Shadia I Jalal.
Transl Lung Cancer Res, 2015 Dec 03; 4(5). PMID: 26629422    Free PMC article.
New strategies in immunotherapy for non-small cell lung cancer.
Daniel R Carrizosa, Kathryn A Gold.
Transl Lung Cancer Res, 2015 Dec 03; 4(5). PMID: 26629424    Free PMC article.
Immunomonitoring in glioma immunotherapy: current status and future perspectives.
Jonathan B Lamano, Leonel Ampie, +5 authors, Orin Bloch.
J Neurooncol, 2015 Dec 08; 127(1). PMID: 26638171    Free PMC article.
Cancer immunotherapy targeting neoantigens.
Yong-Chen Lu, Paul F Robbins.
Semin Immunol, 2015 Dec 15; 28(1). PMID: 26653770    Free PMC article.
Highly Cited. Review.
Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy.
Gerald Goh, Trent Walradt, +11 authors, Jaehyuk Choi.
Oncotarget, 2015 Dec 15; 7(3). PMID: 26655088    Free PMC article.
Highly Cited.
Mismatch repair deficiency associated with complete remission to combination programmed cell death ligand immune therapy in a patient with sporadic urothelial carcinoma: immunotheranostic considerations.
Michael P Castro, Neal Goldstein.
J Immunother Cancer, 2015 Dec 18; 3. PMID: 26674132    Free PMC article.
Importance of immunopharmacogenomics in cancer treatment: Patient selection and monitoring for immune checkpoint antibodies.
Noura Choudhury, Yusuke Nakamura.
Cancer Sci, 2015 Dec 19; 107(2). PMID: 26678880    Free PMC article.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy.
Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake.
Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632    Free PMC article.
Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches.
Clint T Allen, Paul E Clavijo, Carter Van Waes, Zhong Chen.
Cancers (Basel), 2015 Dec 23; 7(4). PMID: 26690220    Free PMC article.
Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors.
Qiong J Wang, Zhiya Yu, +3 authors, James C Yang.
Cancer Immunol Res, 2015 Dec 25; 4(3). PMID: 26701267    Free PMC article.
Predictors of clinical response to immunotherapy with or without radiotherapy.
Susan M Hiniker, Holden T Maecker, Susan J Knox.
J Radiat Oncol, 2015 Dec 29; 4. PMID: 26709361    Free PMC article.
Prospects for gene-engineered T cell immunotherapy for solid cancers.
Christopher A Klebanoff, Steven A Rosenberg, Nicholas P Restifo.
Nat Med, 2016 Jan 07; 22(1). PMID: 26735408    Free PMC article.
Highly Cited.
Epigenetic Therapeutics: A New Weapon in the War Against Cancer.
Nita Ahuja, Anup R Sharma, Stephen B Baylin.
Annu Rev Med, 2016 Jan 16; 67. PMID: 26768237    Free PMC article.
Highly Cited. Review.
Potential biomarker for checkpoint blockade immunotherapy and treatment strategy.
Zhong-Yi Dong, Si-Pei Wu, +2 authors, Yi-Long Wu.
Tumour Biol, 2016 Jan 19; 37(4). PMID: 26779629
Melanoma in 2015: Immune-checkpoint blockade - durable cancer control.
Elizabeth I Buchbinder, F Stephen Hodi.
Nat Rev Clin Oncol, 2016 Jan 21; 13(2). PMID: 26787285
Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab.
Alexander Martens, Kilian Wistuba-Hamprecht, +21 authors, Benjamin Weide.
Clin Cancer Res, 2016 Jan 21; 22(12). PMID: 26787752    Free PMC article.
Highly Cited.
Novel technologies and emerging biomarkers for personalized cancer immunotherapy.
Jianda Yuan, Priti S Hegde, +16 authors, Bernard A Fox.
J Immunother Cancer, 2016 Jan 21; 4. PMID: 26788324    Free PMC article.
Highly Cited. Review.
Integrating the molecular background of targeted therapy and immunotherapy in lung cancer: a way to explore the impact of mutational landscape on tumor immunogenicity.
Sara Pilotto, Miguel Angel Molina-Vila, +6 authors, Rafael Rosell.
Transl Lung Cancer Res, 2016 Jan 23; 4(6). PMID: 26798581    Free PMC article.
Shedding light on the molecular determinants of response to anti-PD-1 therapy.
Ross A Soo.
Transl Lung Cancer Res, 2016 Jan 23; 4(6). PMID: 26798594    Free PMC article.
Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer.
Katsuhiko Nosho, Yasutaka Sukawa, +11 authors, Yasuhisa Shinomura.
World J Gastroenterol, 2016 Jan 27; 22(2). PMID: 26811607    Free PMC article.
Highly Cited. Review.
Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.
Douglas B Johnson, Monica V Estrada, +18 authors, Justin M Balko.
Nat Commun, 2016 Jan 30; 7. PMID: 26822383    Free PMC article.
Highly Cited.
A panoply of errors: polymerase proofreading domain mutations in cancer.
Emily Rayner, Inge C van Gool, +4 authors, David N Church.
Nat Rev Cancer, 2016 Jan 30; 16(2). PMID: 26822575
Highly Cited. Review.
Acquired resistance to immunotherapy and future challenges.
Nicholas P Restifo, Mark J Smyth, Alexandra Snyder.
Nat Rev Cancer, 2016 Jan 30; 16(2). PMID: 26822578    Free PMC article.
Highly Cited.
Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen.
Elena Shklovskaya, Alexandra M Terry, +5 authors, Barbara Fazekas de St. Groth.
Immunol Cell Biol, 2016 Feb 04; 94(6). PMID: 26837456
Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival.
Luc G T Morris, Nadeem Riaz, +5 authors, Timothy A Chan.
Oncotarget, 2016 Feb 04; 7(9). PMID: 26840267    Free PMC article.
Highly Cited.
Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination.
Mathias Vormehr, Barbara Schrörs, +3 authors, Ugur Sahin.
J Immunol Res, 2016 Feb 05; 2015. PMID: 26844233    Free PMC article.
Mutations as munitions: Neoantigen vaccines get a closer look as cancer treatment.
Alla Katsnelson.
Nat Med, 2016 Feb 06; 22(2). PMID: 26845402
Advances in immunotherapy for melanoma.
Jason M Redman, Geoffrey T Gibney, Michael B Atkins.
BMC Med, 2016 Feb 07; 14. PMID: 26850630    Free PMC article.
Highly Cited. Review.
Immunotherapy and Oncogenic Pathways: The PTEN Connection.
Naiyer A Rizvi, Timothy A Chan.
Cancer Discov, 2016 Feb 07; 6(2). PMID: 26851183    Free PMC article.
Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma.
Yanyan Lou, Lixia Diao, +12 authors, Don L Gibbons.
Clin Cancer Res, 2016 Feb 07; 22(14). PMID: 26851185    Free PMC article.
Highly Cited.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Combination Therapies for Melanoma: A New Standard of Care?
Keiran S M Smalley, Zeynep Eroglu, Vernon K Sondak.
Am J Clin Dermatol, 2016 Feb 11; 17(2). PMID: 26860106    Free PMC article.
Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck.
Johannes A Veit, Daniela Heine, +12 authors, Simon Laban.
Head Neck, 2016 Feb 14; 38(7). PMID: 26874246    Free PMC article.
Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma.
Katherine Woods, Ashley J Knights, +4 authors, Jonathan Cebon.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885372    Free PMC article.
PD-1/PD-L1 blockade in cancer treatment: perspectives and issues.
Junzo Hamanishi, Masaki Mandai, +3 authors, Ikuo Konishi.
Int J Clin Oncol, 2016 Feb 24; 21(3). PMID: 26899259    Free PMC article.
Highly Cited. Review.
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients.
Alena Gros, Maria R Parkhurst, +11 authors, Steven A Rosenberg.
Nat Med, 2016 Feb 24; 22(4). PMID: 26901407    Free PMC article.
Highly Cited.
Emerging Tissue and Blood-Based Biomarkers that may Predict Response to Immune Checkpoint Inhibition.
Claire F Friedman, Michael A Postow.
Curr Oncol Rep, 2016 Feb 29; 18(4). PMID: 26922327    Free PMC article.
The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer.
Jeffrey P Ward, Matthew M Gubin, Robert D Schreiber.
Adv Immunol, 2016 Mar 01; 130. PMID: 26922999    Free PMC article.
Highly Cited. Review.
Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities.
K M Morrissey, T M Yuraszeck, +2 authors, S Kasichayanula.
Clin Transl Sci, 2016 Mar 01; 9(2). PMID: 26924066    Free PMC article.
Highly Cited. Review.
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
Nicholas McGranahan, Andrew J S Furness, +33 authors, Charles Swanton.
Science, 2016 Mar 05; 351(6280). PMID: 26940869    Free PMC article.
Highly Cited.
Activation of cytomegalovirus-specific CD8+ T-cell response by antibody-mediated peptide-major histocompatibility class I complexes.
Martina Schmittnaegel, Christian Klein, Victor Levitsky, Hendrik Knoetgen.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942061    Free PMC article.
Doubling the blockade for melanoma immunotherapy.
Lorenzo Galluzzi, Alexander Eggermont, Guido Kroemer.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942094    Free PMC article.
Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections.
Maria Lina Tornesello, Luigi Buonaguro, Francesco Izzo, Franco M Buonaguro.
Oncotarget, 2016 Mar 05; 7(18). PMID: 26943571    Free PMC article.
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.
Jonathan E Rosenberg, Jean Hoffman-Censits, +28 authors, Robert Dreicer.
Lancet, 2016 Mar 10; 387(10031). PMID: 26952546    Free PMC article.
Highly Cited.
Cellular and molecular biology of small cell lung cancer: an overview.
Niki Karachaliou, Sara Pilotto, +3 authors, Rafael Rosell.
Transl Lung Cancer Res, 2016 Mar 10; 5(1). PMID: 26958489    Free PMC article.
Vaccines for established cancer: overcoming the challenges posed by immune evasion.
Sjoerd H van der Burg, Ramon Arens, +2 authors, Cornelis J M Melief.
Nat Rev Cancer, 2016 Mar 12; 16(4). PMID: 26965076
Highly Cited. Review.
Versatile roles of extracellular vesicles in cancer.
Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya.
J Clin Invest, 2016 Mar 15; 126(4). PMID: 26974161    Free PMC article.
Highly Cited. Review.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Melanoma Cancer Stem Cells: Markers and Functions.
Giorgio Parmiani.
Cancers (Basel), 2016 Mar 16; 8(3). PMID: 26978405    Free PMC article.
Improving Systemic Chemotherapy for Bladder Cancer.
Tracy L Rose, Matthew I Milowsky.
Curr Oncol Rep, 2016 Mar 18; 18(5). PMID: 26984414
FDA Approval Summary: Nivolumab for the Treatment of Metastatic Non-Small Cell Lung Cancer With Progression On or After Platinum-Based Chemotherapy.
Dickran Kazandjian, Daniel L Suzman, +5 authors, Richard Pazdur.
Oncologist, 2016 Mar 18; 21(5). PMID: 26984449    Free PMC article.
Highly Cited.
Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer.
Edward J Fox, Jesse J Salk, Lawrence A Loeb.
Genome Med, 2016 Mar 19; 8(1). PMID: 26987311    Free PMC article.
Combining Epigenetic and Immunotherapy to Combat Cancer.
Katherine B Chiappinelli, Cynthia A Zahnow, Nita Ahuja, Stephen B Baylin.
Cancer Res, 2016 Mar 19; 76(7). PMID: 26988985    Free PMC article.
Highly Cited. Review.
Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment.
Stefani Spranger.
Int Immunol, 2016 Mar 19; 28(8). PMID: 26989092    Free PMC article.
Highly Cited. Review.
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma.
Willy Hugo, Jesse M Zaretsky, +15 authors, Roger S Lo.
Cell, 2016 Mar 22; 165(1). PMID: 26997480    Free PMC article.
Highly Cited.
Genomic landscape of DNA repair genes in cancer.
Young Kwang Chae, Jonathan F Anker, +6 authors, Francis J Giles.
Oncotarget, 2016 Mar 24; 7(17). PMID: 27004405    Free PMC article.
Highly Cited.
Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer.
Pietro Parcesepe, Guido Giordano, +2 authors, Massimo Pancione.
Gastroenterol Res Pract, 2016 Mar 24; 2016. PMID: 27006653    Free PMC article.
Case report: mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance.
Kuo-Hsing Chen, Chang-Tsu Yuan, +2 authors, Kun-Huei Yeh.
J Hematol Oncol, 2016 Mar 26; 9. PMID: 27012666    Free PMC article.
Clinical utility of nivolumab in the treatment of advanced melanoma.
Ramsey Asmar, Jessica Yang, Richard D Carvajal.
Ther Clin Risk Manag, 2016 Mar 26; 12. PMID: 27013881    Free PMC article.
Targeting persistent androgen receptor signaling in castration-resistant prostate cancer.
Laura Graham, Michael T Schweizer.
Med Oncol, 2016 Apr 05; 33(5). PMID: 27042852
The role of neoantigens in response to immune checkpoint blockade.
Nadeem Riaz, Luc Morris, +3 authors, Timothy A Chan.
Int Immunol, 2016 Apr 07; 28(8). PMID: 27048318    Free PMC article.
Immunological markers and clinical outcome of advanced melanoma patients receiving ipilimumab plus fotemustine in the NIBIT-M1 study.
Cristina Maccalli, Diana Giannarelli, +5 authors, Michele Maio.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057436    Free PMC article.
Trial Watch-Immunostimulation with cytokines in cancer therapy.
Erika Vacchelli, Fernando Aranda, +10 authors, Lorenzo Galluzzi.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057468    Free PMC article.
Carfilzomib alters the HLA-presented peptidome of myeloma cells and impairs presentation of peptides with aromatic C-termini.
D J Kowalewski, S Walz, +9 authors, J S Stickel.
Blood Cancer J, 2016 Apr 09; 6. PMID: 27058226    Free PMC article.
Opportunities for immunotherapy in microsatellite instable colorectal cancer.
Harm Westdorp, Felix L Fennemann, +7 authors, I Jolanda M de Vries.
Cancer Immunol Immunother, 2016 Apr 10; 65(10). PMID: 27060000    Free PMC article.
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy.
Suzanne L Topalian, Janis M Taube, Robert A Anders, Drew M Pardoll.
Nat Rev Cancer, 2016 Apr 16; 16(5). PMID: 27079802    Free PMC article.
Highly Cited. Review.
Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum.
Douglas B Johnson, Jason Roszik, +7 authors, Scott E Woodman.
Pigment Cell Melanoma Res, 2016 Apr 19; 29(4). PMID: 27089234    Free PMC article.
Kirsten Ras* oncogene: significance of its discovery in human cancer research.
Nobuo Tsuchida, Avaniyapuram Kannan Murugan, Michele Grieco.
Oncotarget, 2016 Apr 23; 7(29). PMID: 27102293    Free PMC article.
Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy.
Rajarsi Mandal, Timothy A Chan.
Cancer Discov, 2016 Apr 24; 6(7). PMID: 27107038    Free PMC article.
Immune Checkpoint Therapy and the Search for Predictive Biomarkers.
Padmanee Sharma.
Cancer J, 2016 Apr 26; 22(2). PMID: 27111900    Free PMC article.
Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity.
Thomas V Guy, Alexandra M Terry, +6 authors, Barbara Fazekas de St. Groth.
Oncotarget, 2016 Apr 29; 7(21). PMID: 27121060    Free PMC article.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
Itay Tirosh, Benjamin Izar, +34 authors, Levi A Garraway.
Science, 2016 Apr 29; 352(6282). PMID: 27124452    Free PMC article.
Highly Cited.
Prime time for immune-checkpoint targeted therapy at ASCO 2015.
Aurélien Marabelle, Bertrand Routy, +2 authors, Laurence Zitvogel.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141332    Free PMC article.
POLE proofreading mutation, immune response and prognosis in endometrial cancer.
Inge C van Gool, Tjalling Bosse, David N Church.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141333    Free PMC article.
Tumor-intrinsic oncogene pathways mediating immune avoidance.
Stefani Spranger, Thomas F Gajewski.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141343    Free PMC article.
Highly Cited. Review.
Immunological correlates of treatment and response in stage IV malignant melanoma patients treated with Ipilimumab.
Jon Bjoern, Nikolaj Juul Nitschke, +3 authors, Inge Marie Svane.
Oncoimmunology, 2016 May 04; 5(4). PMID: 27141381    Free PMC article.
Changing paradigm of cancer therapy: precision medicine by next-generation sequencing.
Yuan Xue, William R Wilcox.
Cancer Biol Med, 2016 May 05; 13(1). PMID: 27144059    Free PMC article.
Clinical Implementation of Novel Targeted Therapeutics in Advanced Breast Cancer.
Mary D Chamberlin, Erica B Bernhardt, Todd W Miller.
J Cell Biochem, 2016 May 06; 117(11). PMID: 27146558    Free PMC article.
Nature Biotechnology's academic spinouts of 2015.
Aaron Bouchie, Laura DeFrancesco.
Nat Biotechnol, 2016 May 08; 34(5). PMID: 27153278
Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer.
Janice M Mehnert, Anshuman Panda, +16 authors, Shridar Ganesan.
J Clin Invest, 2016 May 10; 126(6). PMID: 27159395    Free PMC article.
Highly Cited.
Roles of regulatory T cells in cancer immunity.
Yoshiko Takeuchi, Hiroyoshi Nishikawa.
Int Immunol, 2016 May 11; 28(8). PMID: 27160722    Free PMC article.
Highly Cited. Review.
The Present and Future of Biomarkers in Prostate Cancer: Proteomics, Genomics, and Immunology Advancements.
Pierre-Olivier Gaudreau, John Stagg, Denis Soulières, Fred Saad.
Biomark Cancer, 2016 May 12; 8(Suppl 2). PMID: 27168728    Free PMC article.
Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab.
Alexander Martens, Kilian Wistuba-Hamprecht, +15 authors, Benjamin Weide.
Clin Cancer Res, 2016 May 14; 22(19). PMID: 27169993    Free PMC article.
Highly Cited.
BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells.
Norihiro Ueda, Rong Zhang, +13 authors, Yasushi Uemura.
Cell Mol Immunol, 2016 May 18; 15(1). PMID: 27181332    Free PMC article.
Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.
Luke S Manlove, Jason M Schenkel, +4 authors, Michael A Farrar.
J Immunol, 2016 May 18; 196(11). PMID: 27183622    Free PMC article.
Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab.
Benjamin Weide, Alexander Martens, +24 authors, Jedd D Wolchok.
Clin Cancer Res, 2016 Nov 01; 22(22). PMID: 27185375    Free PMC article.
Highly Cited.
Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines.
Spencer D Martin, Scott D Brown, +5 authors, Brad H Nelson.
PLoS One, 2016 May 19; 11(5). PMID: 27192170    Free PMC article.
Highly Cited.
Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness.
Lance D Miller, Jeff A Chou, +13 authors, Francesco M Marincola.
Cancer Immunol Res, 2016 May 20; 4(7). PMID: 27197066    Free PMC article.
Burden of Nonsynonymous Mutations among TCGA Cancers and Candidate Immune Checkpoint Inhibitor Responses.
Leandro M Colli, Mitchell J Machiela, +3 authors, Stephen J Chanock.
Cancer Res, 2016 May 20; 76(13). PMID: 27197178    Free PMC article.
Highly Cited.
Targeting neoantigens for cancer immunotherapy.
Yong-Chen Lu, Paul F Robbins.
Int Immunol, 2016 May 22; 28(7). PMID: 27208041    Free PMC article.
Future paradigms for precision oncology.
Giannoula Lakka Klement, Knarik Arkun, +20 authors, Jaroslav Sterba.
Oncotarget, 2016 May 26; 7(29). PMID: 27223079    Free PMC article.
Immunotherapy in glioblastoma: emerging options in precision medicine.
Tiffany R Hodges, Sherise D Ferguson, Amy B Heimberger.
CNS Oncol, 2016 May 27; 5(3). PMID: 27225028    Free PMC article.
Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection?
Lucia Festino, Gerardo Botti, +5 authors, Paolo A Ascierto.
Drugs, 2016 May 28; 76(9). PMID: 27229745
Highly Cited. Review.
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy.
Weijie Ma, Barbara M Gilligan, Jianda Yuan, Tianhong Li.
J Hematol Oncol, 2016 May 29; 9(1). PMID: 27234522    Free PMC article.
Highly Cited. Review.
Checkpoint Inhibitors and Their Application in Breast Cancer.
Davide Bedognetti, Cristina Maccalli, +2 authors, Barbara Seliger.
Breast Care (Basel), 2016 May 31; 11(2). PMID: 27239172    Free PMC article.
Monitoring immune responses in the tumor microenvironment.
Jennifer A Wargo, Sangeetha M Reddy, Alexandre Reuben, Padmanee Sharma.
Curr Opin Immunol, 2016 May 31; 41. PMID: 27240055    Free PMC article.
A second chance for telomerase reverse transcriptase in anticancer immunotherapy.
Maurizio Zanetti.
Nat Rev Clin Oncol, 2016 Nov 03; 14(2). PMID: 27245281
Translational and clinical implications of the genetic landscape of prostate cancer.
Daniel E Spratt, Zachary S Zumsteg, Felix Y Feng, Scott A Tomlins.
Nat Rev Clin Oncol, 2016 Jun 02; 13(10). PMID: 27245282    Free PMC article.
Development and clinical application of an integrative genomic approach to personalized cancer therapy.
Andrew V Uzilov, Wei Ding, +41 authors, Rong Chen.
Genome Med, 2016 Jun 02; 8(1). PMID: 27245685    Free PMC article.
When Genome Maintenance Goes Badly Awry.
Elizabeth M Kass, Mary Ellen Moynahan, Maria Jasin.
Mol Cell, 2016 Jun 04; 62(5). PMID: 27259208    Free PMC article.
Biological markers of prognosis, response to therapy and outcome in ovarian carcinoma.
Marta Szajnik, Małgorzata Czystowska-Kuźmicz, Esther Elishaev, Theresa L Whiteside.
Expert Rev Mol Diagn, 2016 Jun 09; 16(8). PMID: 27268121    Free PMC article.
[Molecular and immunohistochemical diagnostics in melanoma].
B Schilling, K G Griewank.
Hautarzt, 2016 Jun 09; 67(7). PMID: 27270408
What does the future hold for immunotherapy in cancer?
Jarushka Naidoo, Bob T Li, Katja Schindler, David B Page.
Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275490    Free PMC article.
RNA splicing factors as oncoproteins and tumour suppressors.
Heidi Dvinge, Eunhee Kim, Omar Abdel-Wahab, Robert K Bradley.
Nat Rev Cancer, 2016 Jun 11; 16(7). PMID: 27282250    Free PMC article.
Highly Cited. Review.
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.
Pei-Ling Chen, Whijae Roh, +41 authors, Jennifer A Wargo.
Cancer Discov, 2016 Jun 16; 6(8). PMID: 27301722    Free PMC article.
Highly Cited.
Genomic profile, smoking, and response to anti-PD-1 therapy in non-small cell lung carcinoma.
Matthew Hellmann, Naiyer Rizvi, Jedd D Wolchok, Timothy A Chan.
Mol Cell Oncol, 2016 Jun 17; 3(1). PMID: 27308563    Free PMC article.
Analysis of PD-L1, T-cell infiltrate and HLA expression in chondrosarcoma indicates potential for response to immunotherapy specifically in the dedifferentiated subtype.
Marie Kostine, Arjen Hg Cleven, +3 authors, Judith V M G Bovée.
Mod Pathol, 2016 Jun 18; 29(9). PMID: 27312065
Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens.
Todd D Prickett, Jessica S Crystal, +11 authors, Paul F Robbins.
Cancer Immunol Res, 2016 Jun 18; 4(8). PMID: 27312342    Free PMC article.
Deficient Mismatch Repair and the Role of Immunotherapy in Metastatic Colorectal Cancer.
Dionisia Quiroga, H Kim Lyerly, Michael A Morse.
Curr Treat Options Oncol, 2016 Jun 18; 17(8). PMID: 27315067
Checkpoint inhibitors and other novel immunotherapies for advanced renal cell carcinoma.
Maria I Carlo, Martin H Voss, Robert J Motzer.
Nat Rev Urol, 2016 Jun 22; 13(7). PMID: 27324121    Free PMC article.
Molecular characterisation of cutaneous melanoma: creating a framework for targeted and immune therapies.
Shivshankari Rajkumar, Ian R Watson.
Br J Cancer, 2016 Jun 24; 115(2). PMID: 27336610    Free PMC article.
MonoSeq Variant Caller Reveals Novel Mononucleotide Run Indel Mutations in Tumors with Defective DNA Mismatch Repair.
Christopher J Walker, Mario A Miranda, +10 authors, Paul J Goodfellow.
Hum Mutat, 2016 Jun 28; 37(10). PMID: 27346418    Free PMC article.
Immune checkpoint inhibitor combinations in solid tumors: opportunities and challenges.
Chrisann Kyi, Michael A Postow.
Immunotherapy, 2016 Jun 29; 8(7). PMID: 27349981    Free PMC article.
Highly Cited. Review.
CTLA-4 Limits Anti-CD20-Mediated Tumor Regression.
Zhenhua Ren, Jingya Guo, +7 authors, Yang-Xin Fu.
Clin Cancer Res, 2016 Jun 30; 23(1). PMID: 27354469    Free PMC article.
The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints.
Santosha Vardhana, Anas Younes.
Haematologica, 2016 Jul 02; 101(7). PMID: 27365459    Free PMC article.
Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies.
Sarah T Garber, Yuuri Hashimoto, +10 authors, Amy B Heimberger.
Neuro Oncol, 2016 Jul 03; 18(10). PMID: 27370400    Free PMC article.
Highly Cited.
Inhibiting Immune Checkpoints for the Treatment of Bladder Cancer.
S Bidnur, R Savdie, P C Black.
Bladder Cancer, 2016 Jul 05; 2(1). PMID: 27376121    Free PMC article.
Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas.
Natalie Vandeven, Paul Nghiem.
Immunotherapy, 2016 Jul 07; 8(8). PMID: 27381685    Free PMC article.
Clinician Perspectives on Current Issues in Lung Cancer Drug Development.
Saiama N Waqar, Philip D Bonomi, +17 authors, Gideon M Blumenthal.
J Thorac Oncol, 2016 Jul 13; 11(9). PMID: 27401214    Free PMC article.
Merkel Cell Carcinoma: An Unusually Immunogenic Cancer Proves Ripe for Immune Therapy.
Natalie A Vandeven, Paul Nghiem.
J Oncol Pract, 2016 Jul 14; 12(7). PMID: 27407162    Free PMC article.
Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade.
Valerie Lee, Adrian Murphy, Dung T Le, Luis A Diaz.
Oncologist, 2016 Jul 15; 21(10). PMID: 27412392    Free PMC article.
Highly Cited. Review.
Metastatic melanoma and immunotherapy.
Benjamin Herzberg, David E Fisher.
Clin Immunol, 2016 Jul 20; 172. PMID: 27430520    Free PMC article.
Tumor infiltrating lymphocytes and PD-L1 expression in brain metastases of small cell lung cancer (SCLC).
Anna Sophie Berghoff, Gerda Ricken, +6 authors, Matthias Preusser.
J Neurooncol, 2016 Oct 21; 130(1). PMID: 27436101
Stem-like features of cancer cells on their way to metastasis.
Sofia Gkountela, Nicola Aceto.
Biol Direct, 2016 Jul 28; 11. PMID: 27457474    Free PMC article.
Immuno-oncology combinations: raising the tail of the survival curve.
Samuel J Harris, Jessica Brown, Juanita Lopez, Timothy A Yap.
Cancer Biol Med, 2016 Jul 28; 13(2). PMID: 27458526    Free PMC article.
The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine.
Andrea Garofalo, Lynette Sholl, +18 authors, Eliezer M Van Allen.
Genome Med, 2016 Jul 28; 8(1). PMID: 27460824    Free PMC article.
Highly Cited.
Characterization of the T-cell receptor beta chain repertoire in tumor-infiltrating lymphocytes.
Katsumi Nakanishi, Yoji Kukita, +3 authors, Kikuya Kato.
Cancer Med, 2016 Jul 29; 5(9). PMID: 27465739    Free PMC article.
Melanoma driver mutations and immune therapy.
Douglas B Johnson, Christine M Lovly, +2 authors, Jeffrey A Sosman.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467925    Free PMC article.
Cripto-1 vaccination elicits protective immunity against metastatic melanoma.
M A Ligtenberg, K Witt, +4 authors, R Kiessling.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467944    Free PMC article.
PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors.
Adrian M Seifert, Shan Zeng, +11 authors, Ronald P DeMatteo.
Clin Cancer Res, 2016 Jul 30; 23(2). PMID: 27470968    Free PMC article.
Prioritization schema for immunotherapy clinical trials in glioblastoma.
Tiffany R Hodges, Sherise D Ferguson, +17 authors, Amy B Heimberger.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471611    Free PMC article.
SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade.
Wei Xue, Rachael L Metheringham, +5 authors, Lindy G Durrant.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471648    Free PMC article.
Molecular profiling of neuroendocrine malignancies to identify prognostic and therapeutic markers: a Fox Chase Cancer Center Pilot Study.
Namrata Vijayvergia, Patrick M Boland, +7 authors, Paul F Engstrom.
Br J Cancer, 2016 Aug 03; 115(5). PMID: 27482646    Free PMC article.
Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients.
Teofila Seremet, Alexander Koch, +12 authors, Bart Neyns.
J Transl Med, 2016 Aug 04; 14(1). PMID: 27484791    Free PMC article.
The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment.
Sara I Pai, Dan P Zandberg, Scott E Strome.
Oral Oncol, 2016 Aug 10; 61. PMID: 27503244    Free PMC article.
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis.
Andrea Schietinger, Mary Philip, +10 authors, Philip D Greenberg.
Immunity, 2016 Aug 16; 45(2). PMID: 27521269    Free PMC article.
Highly Cited.
Circulating protein and antibody biomarker for personalized cancer immunotherapy.
Jianda Yuan.
J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532021    Free PMC article.
PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?
Claud Grigg, Naiyer A Rizvi.
J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532023    Free PMC article.
Highly Cited. Review.
Clinical outcomes in metastatic uveal melanoma treated with PD-1 and PD-L1 antibodies.
Alain P Algazi, Katy K Tsai, +13 authors, Ryan J Sullivan.
Cancer, 2016 Oct 21; 122(21). PMID: 27533448    Free PMC article.
Highly Cited.
The efficacy of anti-PD-1 agents in acral and mucosal melanoma.
Alexander N Shoushtari, Rodrigo R Munhoz, +17 authors, Michael A Postow.
Cancer, 2016 Oct 21; 122(21). PMID: 27533633    Free PMC article.
Highly Cited.
Tumor Mutational Load and Immune Parameters across Metastatic Renal Cell Carcinoma Risk Groups.
Guillermo de Velasco, Diana Miao, +8 authors, Toni K Choueiri.
Cancer Immunol Res, 2016 Aug 20; 4(10). PMID: 27538576    Free PMC article.
Current Progress in Immunotherapy for the Treatment of Biliary Cancers.
James M Pauff, Laura W Goff.
J Gastrointest Cancer, 2016 Aug 20; 47(4). PMID: 27538880
FGFR1 inhibition in lung squamous cell carcinoma: questions and controversies.
C E Weeden, B Solomon, M-L Asselin-Labat.
Cell Death Discov, 2015 Jan 01; 1. PMID: 27551478    Free PMC article.
Neoantigen-based cancer immunotherapy.
Sara Bobisse, Periklis G Foukas, George Coukos, Alexandre Harari.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563649    Free PMC article.
Towards tumor immunodiagnostics.
Helen Kourea, Vassiliki Kotoula.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563650    Free PMC article.
DNA damage, tumor mutational load and their impact on immune responses against cancer.
Michalis Liontos, Ioannis Anastasiou, Aristotelis Bamias, Meletios-Athanasios Dimopoulos.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563651    Free PMC article.
Optimized tumor cryptic peptides: the basis for universal neo-antigen-like tumor vaccines.
Jeanne Menez-Jamet, Catherine Gallou, Aude Rougeot, Kostas Kosmatopoulos.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563653    Free PMC article.
The European Organization for Research and Treatment of Cancer perspective on designing clinical trials with immune therapeutics.
Jessica Menis, Saskia Litière, Konstantinos Tryfonidis, Vassilis Golfinopoulos.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563654    Free PMC article.
A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling.
Heather L McArthur, Adi Diab, +27 authors, Larry Norton.
Clin Cancer Res, 2016 Nov 05; 22(23). PMID: 27566765    Free PMC article.
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes.
Amalie Kai Bentzen, Andrea Marion Marquard, +15 authors, Sine Reker Hadrup.
Nat Biotechnol, 2016 Aug 30; 34(10). PMID: 27571370
Highly Cited.
Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.
Minmin Liu, Hitoshi Ohtani, +8 authors, Peter A Jones.
Proc Natl Acad Sci U S A, 2016 Aug 31; 113(37). PMID: 27573823    Free PMC article.
Highly Cited.
GBM-associated mutations and altered protein expression are more common in young patients.
Sherise D Ferguson, Joanne Xiu, +8 authors, Amy B Heimberger.
Oncotarget, 2016 Sep 01; 7(43). PMID: 27579614    Free PMC article.
Strategies to modulate the immune system in breast cancer: checkpoint inhibitors and beyond.
Cristina Migali, Monica Milano, +5 authors, Giuseppe Curigliano.
Ther Adv Med Oncol, 2016 Sep 02; 8(5). PMID: 27583028    Free PMC article.
Concordance between genomic alterations assessed by next-generation sequencing in tumor tissue or circulating cell-free DNA.
Young Kwang Chae, Andrew A Davis, +11 authors, Francis J Giles.
Oncotarget, 2016 Sep 03; 7(40). PMID: 27588476    Free PMC article.
Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells.
Blanca Homet Moreno, Jesse M Zaretsky, +11 authors, Antoni Ribas.
Cancer Immunol Res, 2016 Sep 04; 4(10). PMID: 27589875    Free PMC article.
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.
Maria Secrier, Xiaodun Li, +24 authors, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium.
Nat Genet, 2016 Sep 07; 48(10). PMID: 27595477    Free PMC article.
Highly Cited.
Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes.
Andreas Gloger, Danilo Ritz, Tim Fugmann, Dario Neri.
Cancer Immunol Immunother, 2016 Oct 21; 65(11). PMID: 27600516    Free PMC article.
Addressing intra-tumoral heterogeneity and therapy resistance.
Brad Rybinski, Kyuson Yun.
Oncotarget, 2016 Sep 10; 7(44). PMID: 27608848    Free PMC article.
Present Yourself! By MHC Class I and MHC Class II Molecules.
Kenneth L Rock, Eric Reits, Jacques Neefjes.
Trends Immunol, 2016 Sep 12; 37(11). PMID: 27614798    Free PMC article.
Highly Cited. Review.
Calreticulin expression: Interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer.
Gautier Stoll, Kristina Iribarren, +4 authors, Guido Kroemer.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622029    Free PMC article.
[Immunotherapy for HNSCC : Quo vadis?].
J Döscher, C-J Busch, P J Schuler, S Laban.
HNO, 2016 Sep 15; 64(10). PMID: 27624904
High-content molecular profiling of T-cell therapy in oncology.
Ruslan Novosiadly, Michael Kalos.
Mol Ther Oncolytics, 2016 Sep 15; 3. PMID: 27626060    Free PMC article.
Defining Glomerular Disease in Mechanistic Terms: Implementing an Integrative Biology Approach in Nephrology.
Laura H Mariani, William F Pendergraft, Matthias Kretzler.
Clin J Am Soc Nephrol, 2016 Sep 16; 11(11). PMID: 27630182    Free PMC article.
Current management and future directions in metastatic pancreatic adenocarcinoma.
Anna M Varghese, Maeve A Lowery, Kenneth H Yu, Eileen M O'Reilly.
Cancer, 2016 Sep 21; 122(24). PMID: 27649047    Free PMC article.
The genetics of uveal melanoma: current insights.
Hildur Helgadottir, Veronica Höiom.
Appl Clin Genet, 2016 Sep 24; 9. PMID: 27660484    Free PMC article.
A retrospective analysis of High-Dose Interleukin-2 (HD IL-2) following Ipilimumab in metastatic melanoma.
Elizabeth I Buchbinder, Anasuya Gunturi, +17 authors, David F McDermott.
J Immunother Cancer, 2016 Sep 24; 4. PMID: 27660706    Free PMC article.
Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies.
Sander Bins, Geert A Cirkel, +19 authors, Martijn P Lolkema.
Oncologist, 2016 Sep 25; 22(1). PMID: 27662884    Free PMC article.
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.
Marcel Smid, F Germán Rodríguez-González, +44 authors, John W M Martens.
Nat Commun, 2016 Sep 27; 7. PMID: 27666519    Free PMC article.
Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.
Nadeem Riaz, Jonathan J Havel, +5 authors, Timothy A Chan.
Nat Genet, 2016 Oct 28; 48(11). PMID: 27668655    Free PMC article.
Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade.
Douglas B Johnson, Garrett M Frampton, +24 authors, Christine M Lovly.
Cancer Immunol Res, 2016 Nov 03; 4(11). PMID: 27671167    Free PMC article.
Highly Cited.
Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells.
Elliott J Brea, Claire Y Oh, +15 authors, David A Scheinberg.
Cancer Immunol Res, 2016 Nov 03; 4(11). PMID: 27680026    Free PMC article.
The efficacy and safety of anti-PD-1/PD-L1 antibodies for treatment of advanced or refractory cancers: a meta-analysis.
Tengfei Zhang, Jing Xie, +13 authors, Yi Zhang.
Oncotarget, 2016 Sep 30; 7(45). PMID: 27683031    Free PMC article.
The full blood count as a biomarker of outcome and toxicity in ipilimumab-treated cutaneous metastatic melanoma.
Leila Khoja, Eshetu G Atenafu, +6 authors, Anthony M Joshua.
Cancer Med, 2016 Oct 30; 5(10). PMID: 27683208    Free PMC article.
Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy.
Tanner M Johanns, Christopher A Miller, +10 authors, Gavin P Dunn.
Cancer Discov, 2016 Nov 04; 6(11). PMID: 27683556    Free PMC article.
Highly Cited.
Mouse models in oncoimmunology.
Laurence Zitvogel, Jonathan M Pitt, +2 authors, Guido Kroemer.
Nat Rev Cancer, 2016 Nov 04; 16(12). PMID: 27687979
Highly Cited. Review.
Precision medicine from the renal cancer genome.
Yasser Riazalhosseini, Mark Lathrop.
Nat Rev Nephrol, 2016 Oct 04; 12(11). PMID: 27694978
Genomic Approaches to Understanding Response and Resistance to Immunotherapy.
David A Braun, Kelly P Burke, Eliezer M Van Allen.
Clin Cancer Res, 2016 Oct 05; 22(23). PMID: 27698000    Free PMC article.
Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective.
Guoli Chen, Zhaohai Yang, +2 authors, Ming-Tseh Lin.
Biomed Res Int, 2016 Oct 05; 2016. PMID: 27699178    Free PMC article.
Claudin-low bladder tumors are immune infiltrated and actively immune suppressed.
Jordan Kardos, Shengjie Chai, +8 authors, Benjamin G Vincent.
JCI Insight, 2016 Oct 05; 1(3). PMID: 27699256    Free PMC article.
Highly Cited.
Resistance patterns to anti-PD-1 therapy in metastatic melanoma.
Alpaslan Ozgun, Vernon K Sondak, Joseph Markowitz.
Chin Clin Oncol, 2016 Oct 06; 5(6). PMID: 27701871    Free PMC article.
Recent advances in T-cell engineering for use in immunotherapy.
Preeti Sharma, David M Kranz.
F1000Res, 2016 Oct 06; 5. PMID: 27703664    Free PMC article.
Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth.
Anne Mobergslien, Qian Peng, Vlada Vasovic, Mouldy Sioud.
Oncotarget, 2016 Oct 08; 7(46). PMID: 27713158    Free PMC article.
Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.
Anna E Kersh, Maiko Sasaki, +2 authors, Brian P Pollack.
Front Pharmacol, 2016 Oct 13; 7. PMID: 27729860    Free PMC article.
The promise of PD-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. PD-L1.
Zhaohui Jin, Harry H Yoon.
J Gastrointest Oncol, 2016 Oct 18; 7(5). PMID: 27747091    Free PMC article.
Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma.
Paul Zolkind, Gavin P Dunn, +3 authors, Ravindra Uppaluri.
Oral Oncol, 2016 Oct 19; 71. PMID: 27751760    Free PMC article.
Mismatch repair deficiency may be common in ductal adenocarcinoma of the prostate.
Michael T Schweizer, Heather H Cheng, +9 authors, Colin C Pritchard.
Oncotarget, 2016 Oct 21; 7(50). PMID: 27756888    Free PMC article.
Effective induction of cytotoxic T cells recognizing an epitope peptide derived from hypoxia-inducible protein 2 (HIG2) in patients with metastatic renal cell carcinoma.
Wataru Obara, Takashi Karashima, +9 authors, Tomoaki Fujioka.
Cancer Immunol Immunother, 2016 Oct 21; 66(1). PMID: 27757561    Free PMC article.
Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death.
Frederick J Kohlhapp, Erica J Huelsmann, +25 authors, Andrew Zloza.
Cell Rep, 2016 Oct 21; 17(4). PMID: 27760326    Free PMC article.
Combining Radiation Therapy with Immune Checkpoint Blockade for Central Nervous System Malignancies.
Neil M D'Souza, Penny Fang, +3 authors, Jing Li.
Front Oncol, 2016 Oct 25; 6. PMID: 27774435    Free PMC article.
Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
Jason Roszik, Lauren E Haydu, +25 authors, Scott E Woodman.
BMC Med, 2016 Oct 26; 14(1). PMID: 27776519    Free PMC article.
Highly Cited.
Lymphocyte activation gene 3 and coronary artery disease.
Diana Golden, Antonina Kolmakova, +8 authors, Annabelle Rodriguez.
JCI Insight, 2016 Oct 26; 1(17). PMID: 27777974    Free PMC article.
The head and neck cancer immune landscape and its immunotherapeutic implications.
Rajarsi Mandal, Yasin Şenbabaoğlu, +8 authors, Luc Gt Morris.
JCI Insight, 2016 Oct 26; 1(17). PMID: 27777979    Free PMC article.
Highly Cited.
Aptamers: A New Technological Platform in Cancer Immunotherapy.
Fernando Pastor.
Pharmaceuticals (Basel), 2016 Oct 27; 9(4). PMID: 27783034    Free PMC article.
High-Accuracy HLA Type Inference from Whole-Genome Sequencing Data Using Population Reference Graphs.
Alexander T Dilthey, Pierre-Antoine Gourraud, +3 authors, Gil McVean.
PLoS Comput Biol, 2016 Oct 30; 12(10). PMID: 27792722    Free PMC article.
Recent advances in understanding antitumor immunity.
Rodrigo Ramella Munhoz, Michael Andrew Postow.
F1000Res, 2016 Nov 03; 5. PMID: 27803807    Free PMC article.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.
Vassiliki A Boussiotis.
N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234    Free PMC article.
Highly Cited. Review.
Successful Treatment of a Patient with Glioblastoma and a Germline POLE Mutation: Where Next?
Alexandra Snyder, Jedd D Wolchok.
Cancer Discov, 2016 Nov 04; 6(11). PMID: 27807100    Free PMC article.
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.
Wei Xue, Victoria A Brentville, +4 authors, Lindy G Durrant.
Oncotarget, 2016 Nov 09; 7(50). PMID: 27825115    Free PMC article.
Gene-expression profiling to predict responsiveness to immunotherapy.
N B Jamieson, A V Maker.
Cancer Gene Ther, 2016 Nov 12; 24(3). PMID: 27834354    Free PMC article.
Making urothelial carcinomas less immune to immunotherapy.
Jorge D Ramos, Evan Y Yu.
Urol Oncol, 2016 Nov 12; 34(12). PMID: 27836245    Free PMC article.
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers.
Randy F Sweis, Matthew D Galsky.
Urol Oncol, 2016 Nov 12; 34(12). PMID: 27836246    Free PMC article.
Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma.
Stefani Spranger, Jason J Luke, +6 authors, Thomas F Gajewski.
Proc Natl Acad Sci U S A, 2016 Nov 12; 113(48). PMID: 27837020    Free PMC article.
Highly Cited.
Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors.
Ludmila Danilova, Hao Wang, +9 authors, Janis M Taube.
Proc Natl Acad Sci U S A, 2016 Nov 12; 113(48). PMID: 27837027    Free PMC article.
Highly Cited.
Immune checkpoint blockade in small cell lung cancer: is there a light at the end of the tunnel?
Luca Paglialunga, Zena Salih, Biagio Ricciuti, Raffaele Califano.
ESMO Open, 2016 Nov 16; 1(4). PMID: 27843619    Free PMC article.
Recent advances in the biology of human circulating tumour cells and metastasis.
Sofia Gkountela, Barbara Szczerba, Cinzia Donato, Nicola Aceto.
ESMO Open, 2016 Nov 16; 1(4). PMID: 27843628    Free PMC article.
Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures.
Yasin Şenbabaoğlu, Ron S Gejman, +26 authors, A Ari Hakimi.
Genome Biol, 2016 Nov 20; 17(1). PMID: 27855702    Free PMC article.
Highly Cited.
The Role of Next-Generation Sequencing in Enabling Personalized Oncology Therapy.
C A Cummings, E Peters, +2 authors, M R Lackner.
Clin Transl Sci, 2016 Nov 20; 9(6). PMID: 27860319    Free PMC article.
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Michal Bassani-Sternberg, Eva Bräunlein, +16 authors, Angela M Krackhardt.
Nat Commun, 2016 Nov 22; 7. PMID: 27869121    Free PMC article.
Highly Cited.
Combinational Immunotherapy with Allo-DRibble Vaccines and Anti-OX40 Co-Stimulation Leads to Generation of Cross-Reactive Effector T Cells and Tumor Regression.
Guangjie Yu, Yuhuan Li, +6 authors, Hong-Ming Hu.
Sci Rep, 2016 Nov 23; 6. PMID: 27874054    Free PMC article.
Comparison of exome-based HLA class I genotyping tools: identification of platform-specific genotyping errors.
Kazuma Kiyotani, Tu H Mai, Yusuke Nakamura.
J Hum Genet, 2016 Nov 25; 62(3). PMID: 27881843    Free PMC article.
Advances in Cancer Immunotherapy in Solid Tumors.
Smitha Menon, Sarah Shin, Grace Dy.
Cancers (Basel), 2016 Nov 26; 8(12). PMID: 27886124    Free PMC article.
Highly Cited. Review.
Validation of biomarkers to predict response to immunotherapy in cancer: Volume I - pre-analytical and analytical validation.
Giuseppe V Masucci, Alessandra Cesano, +10 authors, Magdalena Thurin.
J Immunother Cancer, 2016 Nov 30; 4. PMID: 27895917    Free PMC article.
Highly Cited. Review.
The role of immune checkpoint inhibition in the treatment of ovarian cancer.
Stéphanie L Gaillard, Angeles A Secord, Bradley Monk.
Gynecol Oncol Res Pract, 2016 Dec 03; 3. PMID: 27904752    Free PMC article.
Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting.
Julie E Bauman, Ezra Cohen, +17 authors, Shakun Malik.
Cancer, 2016 Dec 03; 123(7). PMID: 27906454    Free PMC article.
Robust detection of immune transcripts in FFPE samples using targeted RNA sequencing.
Benjamin E Paluch, Sean T Glenn, +14 authors, Carl D Morrison.
Oncotarget, 2016 Dec 03; 8(2). PMID: 27911273    Free PMC article.
Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine.
Gerald Goh, Ramona Schmid, +16 authors, Charles Swanton.
PLoS Med, 2016 Dec 07; 13(12). PMID: 27923043    Free PMC article.
Predictive biomarkers for checkpoint inhibitor-based immunotherapy.
Geoffrey T Gibney, Louis M Weiner, Michael B Atkins.
Lancet Oncol, 2016 Dec 08; 17(12). PMID: 27924752    Free PMC article.
Highly Cited. Review.
Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade.
Tavi Nathanson, Arun Ahuja, +8 authors, Jeff Hammerbacher.
Cancer Immunol Res, 2016 Dec 14; 5(1). PMID: 27956380    Free PMC article.
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.
Eric Tran, Paul F Robbins, +9 authors, Steven A Rosenberg.
N Engl J Med, 2016 Dec 14; 375(23). PMID: 27959684    Free PMC article.
Highly Cited.
Immunotherapy in the Precision Medicine Era: Melanoma and Beyond.
Mack Y Su, David E Fisher.
PLoS Med, 2016 Dec 14; 13(12). PMID: 27959922    Free PMC article.
Predictors of Chemosensitivity in Triple Negative Breast Cancer: An Integrated Genomic Analysis.
Tingting Jiang, Weiwei Shi, +8 authors, Christos Hatzis.
PLoS Med, 2016 Dec 14; 13(12). PMID: 27959926    Free PMC article.
Immuno-Oncology: The Third Paradigm in Early Drug Development.
Juan Martin-Liberal, Cinta Hierro, Maria Ochoa de Olza, Jordi Rodon.
Target Oncol, 2016 Dec 21; 12(2). PMID: 27995439
Immunotherapy of Malignant Tumors in the Brain: How Different from Other Sites?
Valérie Dutoit, Denis Migliorini, Pierre-Yves Dietrich, Paul R Walker.
Front Oncol, 2016 Dec 23; 6. PMID: 28003994    Free PMC article.
Dendritic cell-based immunotherapy.
Rachel L Sabado, Sreekumar Balan, Nina Bhardwaj.
Cell Res, 2016 Dec 28; 27(1). PMID: 28025976    Free PMC article.
Highly Cited. Review.
Immune targets and neoantigens for cancer immunotherapy and precision medicine.
Rong-Fu Wang, Helen Y Wang.
Cell Res, 2016 Dec 28; 27(1). PMID: 28025978    Free PMC article.
Highly Cited. Review.
Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer.
Valsamo Anagnostou, Kellie N Smith, +26 authors, Victor E Velculescu.
Cancer Discov, 2016 Dec 30; 7(3). PMID: 28031159    Free PMC article.
Highly Cited.
Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire.
David Y Oh, Jason Cham, +5 authors, Lawrence Fong.
Cancer Res, 2016 Dec 30; 77(6). PMID: 28031229    Free PMC article.
Challenges and opportunities for checkpoint blockade in T-cell lymphoproliferative disorders.
Tycel Phillips, Sumana Devata, Ryan A Wilcox.
J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031823    Free PMC article.
Checkpoint Inhibitors for Advanced Bladder Cancer.
Edward M Messing.
Bladder Cancer, 2016 Dec 31; 2(4). PMID: 28035330    Free PMC article.
How "precise" is precision medicine in hematology?
Carlo Gambacorti-Passerini, Rocco Piazza.
Haematologica, 2017 Jan 04; 102(1). PMID: 28040787    Free PMC article.
Identification of coding and non-coding mutational hotspots in cancer genomes.
Scott W Piraino, Simon J Furney.
BMC Genomics, 2017 Jan 07; 18(1). PMID: 28056774    Free PMC article.
Near future of tumor immunology: Anticipating resistance mechanisms to immunotherapies, a big challenge for clinical trials.
João Paulo Portela Catani, Rachel P Riechelmann, Sandy Adjemian, Bryan E Strauss.
Hum Vaccin Immunother, 2017 Jan 07; 13(5). PMID: 28059608    Free PMC article.
The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment.
Shona A Hendry, Rae H Farnsworth, +3 authors, Stephen B Fox.
Front Immunol, 2017 Jan 10; 7. PMID: 28066431    Free PMC article.
Highly Cited. Review.
Identification of immunoglobulin V(D)J recombinations in solid tumor specimen exome files: Evidence for high level B-cell infiltrates in breast cancer.
Wei Lue Tong, Yaping N Tu, +2 authors, George Blanck.
Hum Vaccin Immunother, 2017 Jan 14; 13(3). PMID: 28085544    Free PMC article.
A phase 2 study of alisertib (MLN8237) in recurrent or persistent uterine leiomyosarcoma: An NRG Oncology/Gynecologic Oncology Group study 0231D.
David M Hyman, Michael W Sill, +9 authors, Martee L Hensley.
Gynecol Oncol, 2017 Jan 18; 144(1). PMID: 28094040    Free PMC article.
Genomic analysis and clinical management of adolescent cutaneous melanoma.
Roy Rabbie, Mamunur Rashid, +13 authors, David J Adams.
Pigment Cell Melanoma Res, 2017 Jan 18; 30(3). PMID: 28097802    Free PMC article.
Elements of cancer immunity and the cancer-immune set point.
Daniel S Chen, Ira Mellman.
Nature, 2017 Jan 20; 541(7637). PMID: 28102259
Highly Cited. Review.
T-cell receptor-engineered T cells for cancer treatment: current status and future directions.
Yu Ping, Chaojun Liu, Yi Zhang.
Protein Cell, 2017 Jan 22; 9(3). PMID: 28108950    Free PMC article.
Highly Cited. Review.
Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
Giuseppe Palmieri, Maria Colombino, +3 authors, Paolo A Ascierto.
J Transl Med, 2017 Jan 23; 15(1). PMID: 28109293    Free PMC article.
Radiotherapy and Immune Checkpoint Blockade for Melanoma: A Promising Combinatorial Strategy in Need of Further Investigation.
Freddy E Escorcia, Michael A Postow, Christopher A Barker.
Cancer J, 2017 Jan 24; 23(1). PMID: 28114252    Free PMC article.
It's a long way to the top (if you want to personalize immunotherapy).
Sarah Haebe, Oliver Weigert.
J Immunother Cancer, 2017 Jan 25; 5. PMID: 28116089    Free PMC article.
Strong Correlation of Indoleamine 2,3-Dioxygenase 1 Expression with Basal-Like Phenotype and Increased Lymphocytic Infiltration in Triple-Negative Breast Cancer.
Sewha Kim, Sanghui Park, +3 authors, Sun Hee Sung.
J Cancer, 2017 Jan 27; 8(1). PMID: 28123606    Free PMC article.
Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients.
Yumi Nonomura, Atsushi Otsuka, +14 authors, Kenji Kabashima.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123885    Free PMC article.
Clinical implication of tumor-associated and immunological parameters in melanoma patients treated with ipilimumab.
V Damuzzo, S Solito, +6 authors, S Mandruzzato.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123888    Free PMC article.
MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy.
Simon Laban, Gregor Giebel, +18 authors, Sven Perner.
Oncotarget, 2017 Feb 02; 8(9). PMID: 28146422    Free PMC article.
A meta-analysis of HLA peptidome composition in different hematological entities: entity-specific dividing lines and "pan-leukemia" antigens.
Linus Backert, Daniel Johannes Kowalewski, +14 authors, Juliane Sarah Walz.
Oncotarget, 2017 Feb 06; 8(27). PMID: 28159928    Free PMC article.
Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients.
Kilian Wistuba-Hamprecht, Alexander Martens, +18 authors, Benjamin Weide.
Eur J Cancer, 2017 Feb 09; 73. PMID: 28167454    Free PMC article.
Next steps in immuno-oncology: enhancing antitumor effects through appropriate patient selection and rationally designed combination strategies.
A K S Salama, S J Moschos.
Ann Oncol, 2017 Feb 09; 28(1). PMID: 28177433    Free PMC article.
Comprehensive analysis of PD-L1 expression in glioblastoma multiforme.
Dieter Henrik Heiland, Gerrit Haaker, +9 authors, Oliver Schnell.
Oncotarget, 2017 Feb 09; 8(26). PMID: 28178682    Free PMC article.
Applications of Immunogenomics to Cancer.
X Shirley Liu, Elaine R Mardis.
Cell, 2017 Feb 12; 168(4). PMID: 28187283    Free PMC article.
Highly Cited. Review.
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.
Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas.
Cell, 2017 Feb 12; 168(4). PMID: 28187290    Free PMC article.
Highly Cited. Review.
Transcriptional Mechanisms of Resistance to Anti-PD-1 Therapy.
Maria L Ascierto, Alvin Makohon-Moore, +18 authors, Suzanne L Topalian.
Clin Cancer Res, 2017 Feb 15; 23(12). PMID: 28193624    Free PMC article.
Analysis of the prognostic role of an immune checkpoint score in resected non-small cell lung cancer patients.
Marta Usó, Eloísa Jantus-Lewintre, +6 authors, Rafael Sirera.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197383    Free PMC article.
'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations.
Eric Tran, Paul F Robbins, Steven A Rosenberg.
Nat Immunol, 2017 Feb 16; 18(3). PMID: 28198830    Free PMC article.
Highly Cited. Review.
Targeting PD-1/PD-L1 in lung cancer: current perspectives.
María González-Cao, Niki Karachaliou, +6 authors, Rafael Rosell.
Lung Cancer (Auckl), 2015 Jul 31; 6. PMID: 28210151    Free PMC article.
Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma.
Suzanne George, Diana Miao, +13 authors, Eliezer M Van Allen.
Immunity, 2017 Feb 24; 46(2). PMID: 28228279    Free PMC article.
Highly Cited.
Targeting neoantigens to augment antitumour immunity.
Mark Yarchoan, Burles A Johnson, +2 authors, Elizabeth M Jaffee.
Nat Rev Cancer, 2017 Feb 25; 17(4). PMID: 28233802    Free PMC article.
Highly Cited. Review.
A Novel DNA Vaccine Platform Enhances Neo-antigen-like T Cell Responses against WT1 to Break Tolerance and Induce Anti-tumor Immunity.
Jewell N Walters, Bernadette Ferraro, +8 authors, David B Weiner.
Mol Ther, 2017 Feb 27; 25(4). PMID: 28237837    Free PMC article.
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.
Whijae Roh, Pei-Ling Chen, +37 authors, P Andrew Futreal.
Sci Transl Med, 2017 Mar 03; 9(379). PMID: 28251903    Free PMC article.
Highly Cited.
Tissue-specific tumorigenesis: context matters.
Günter Schneider, Marc Schmidt-Supprian, Roland Rad, Dieter Saur.
Nat Rev Cancer, 2017 Mar 04; 17(4). PMID: 28256574    Free PMC article.
Highly Cited. Review.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.
Liliana E Lucca, David A Hafler.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258696    Free PMC article.
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance.
Weiwei Wang, Lijun Zhang, +5 authors, Shaojia Wang.
Oncol Rep, 2017 Mar 06; 37(4). PMID: 28260069    Free PMC article.
Debugging the Black Box.
James C Yang.
Cancer Discov, 2017 Mar 08; 7(3). PMID: 28264866    Free PMC article.
Manipulation of Innate and Adaptive Immunity through Cancer Vaccines.
Elias J Sayour, Duane A Mitchell.
J Immunol Res, 2017 Mar 08; 2017. PMID: 28265580    Free PMC article.
Precision medicine driven by cancer systems biology.
Fabian V Filipp.
Cancer Metastasis Rev, 2017 Mar 08; 36(1). PMID: 28265786    Free PMC article.
ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.
Chi-Fen Chen, Rolando Ruiz-Vega, +9 authors, Anand K Ganesan.
Cell Rep, 2017 Mar 09; 18(10). PMID: 28273450    Free PMC article.
Current companion diagnostics in advanced colorectal cancer; getting a bigger and better piece of the pie.
Jonathan M Loree, Scott Kopetz, Kanwal P S Raghav.
J Gastrointest Oncol, 2017 Mar 11; 8(1). PMID: 28280626    Free PMC article.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma.
Manohan Sinnadurai, Kerrie L McDonald.
J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764
Immune Checkpoint Inhibitors in Gliomas.
Aaron C Tan, Amy B Heimberger, Mustafa Khasraw.
Curr Oncol Rep, 2017 Mar 18; 19(4). PMID: 28303490
The Five Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy.
Suneetha Amara, Venkataswarup Tiriveedhi.
Int J Mol Sci, 2017 Mar 18; 18(3). PMID: 28304339    Free PMC article.
Immunotherapy: a new treatment paradigm in bladder cancer.
Nicole N Davarpanah, Akira Yuno, Jane B Trepel, Andrea B Apolo.
Curr Opin Oncol, 2017 Mar 18; 29(3). PMID: 28306559    Free PMC article.
Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia.
Stacy A Malaker, Sarah A Penny, +7 authors, Mark Cobbold.
Cancer Immunol Res, 2017 Mar 21; 5(5). PMID: 28314751    Free PMC article.
Evolution of MHC-based technologies used for detection of antigen-responsive T cells.
Amalie Kai Bentzen, Sine Reker Hadrup.
Cancer Immunol Immunother, 2017 Mar 21; 66(5). PMID: 28314956    Free PMC article.
Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines.
Jason Lohmueller, Olivera J Finn.
Pharmacol Ther, 2017 Mar 23; 178. PMID: 28322974    Free PMC article.
Systematic evaluation of immune regulation and modulation.
David F Stroncek, Lisa H Butterfield, +12 authors, Barbara Seliger.
J Immunother Cancer, 2017 Mar 24; 5. PMID: 28331613    Free PMC article.
MAGE-A Antigens and Cancer Immunotherapy.
Paul Zajac, Elke Schultz-Thater, +5 authors, Giulio C Spagnoli.
Front Med (Lausanne), 2017 Mar 25; 4. PMID: 28337438    Free PMC article.
Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis.
Wouter Hendrickx, Ines Simeone, +14 authors, Davide Bedognetti.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344865    Free PMC article.
Highly Cited.
Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition.
Florine A Eggink, Inge C Van Gool, +11 authors, Tjalling Bosse.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344870    Free PMC article.
Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma.
Kazuma Kiyotani, Jae-Hyun Park, +5 authors, Wickii T Vigneswaran.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344893    Free PMC article.
Pharmacogenomics of off-target adverse drug reactions.
Sarah L Garon, Rebecca K Pavlos, +3 authors, Elizabeth J Phillips.
Br J Clin Pharmacol, 2017 Mar 28; 83(9). PMID: 28345177    Free PMC article.
Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers.
Erik S Knudsen, Paris Vail, +9 authors, Agnieszka K Witkiewicz.
Clin Cancer Res, 2017 Mar 30; 23(15). PMID: 28348045    Free PMC article.
Highly Cited.
Molecular genetic and immunotherapeutic targets in metastatic melanoma.
C Melis, A Rogiers, O Bechter, Joost J van den Oord.
Virchows Arch, 2017 Mar 31; 471(2). PMID: 28357489
Ultrasensitive detection of TCR hypervariable-region sequences in solid-tissue RNA-seq data.
Bo Li, Taiwen Li, +4 authors, X Shirley Liu.
Nat Genet, 2017 Mar 31; 49(4). PMID: 28358132    Free PMC article.
The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation.
Florian Wolff, Michael Leisch, +2 authors, Lisa Pleyer.
Cell Commun Signal, 2017 Apr 01; 15(1). PMID: 28359286    Free PMC article.
Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ.
Ruth J Davis, Ellen C Moore, +6 authors, Clint Allen.
Cancer Res, 2017 Apr 02; 77(10). PMID: 28364000    Free PMC article.
Highly Cited.
Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy.
Tiffany R Hodges, Martina Ott, +9 authors, Amy B Heimberger.
Neuro Oncol, 2017 Apr 04; 19(8). PMID: 28371827    Free PMC article.
Highly Cited.
Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma.
Winnie S Liang, William Hendricks, +23 authors, Jeffrey Trent.
Genome Res, 2017 Apr 05; 27(4). PMID: 28373299    Free PMC article.
Targeted Therapies for Melanoma Brain Metastases.
Anna S Berghoff, Matthias Preusser.
Curr Treat Options Neurol, 2017 Apr 05; 19(4). PMID: 28374234    Free PMC article.
Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment.
James L Gulley, Ravi A Madan, +4 authors, Charles G Drake.
J Natl Cancer Inst, 2017 Apr 05; 109(4). PMID: 28376158    Free PMC article.
Highly Cited. Review.
Cancer immunotherapies targeting the PD-1 signaling pathway.
Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo.
J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884    Free PMC article.
Highly Cited. Review.
UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model.
Jake Wang, Curtis J Perry, +6 authors, Marcus Bosenberg.
Pigment Cell Melanoma Res, 2017 Apr 06; 30(4). PMID: 28379630    Free PMC article.
Highly Cited.
Tumor Vaccines for Malignant Gliomas.
Visish M Srinivasan, Sherise D Ferguson, +3 authors, Amy B Heimberger.
Neurotherapeutics, 2017 Apr 09; 14(2). PMID: 28389997    Free PMC article.
Emerging role of mutations in epigenetic regulators including MLL2 derived from The Cancer Genome Atlas for cervical cancer.
Xia Li.
BMC Cancer, 2017 Apr 10; 17(1). PMID: 28390392    Free PMC article.
Clinical Features of Acquired Resistance to Anti-PD-1 Therapy in Advanced Melanoma.
Daniel Y Wang, Zeynep Eroglu, +11 authors, Elizabeth I Buchbinder.
Cancer Immunol Res, 2017 Apr 12; 5(5). PMID: 28396509    Free PMC article.
Indicators of responsiveness to immune checkpoint inhibitors.
Bradley D Shields, Fade Mahmoud, +10 authors, Alan J Tackett.
Sci Rep, 2017 Apr 13; 7(1). PMID: 28400597    Free PMC article.
Resistance to immunotherapy: clouds in a bright sky.
Gérard Milano.
Invest New Drugs, 2017 Apr 13; 35(5). PMID: 28401366
HLA class I-restricted MYD88 L265P-derived peptides as specific targets for lymphoma immunotherapy.
Annika Nelde, Juliane Sarah Walz, +14 authors, Alexander N R Weber.
Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405493    Free PMC article.
Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody.
Andres Lopez-Albaitero, Hong Xu, +8 authors, Nai-Kong V Cheung.
Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405494    Free PMC article.
PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma.
Jan Budczies, Gunhild Mechtersheimer, +17 authors, Albrecht Stenzinger.
Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405504    Free PMC article.
Applied Cancer Immunogenomics: Leveraging Neoantigen Discovery in Glioblastoma.
Tanner M Johanns, Gavin P Dunn.
Cancer J, 2017 Apr 15; 23(2). PMID: 28410300    Free PMC article.
Antigen Discovery and Therapeutic Targeting in Hematologic Malignancies.
David A Braun, Catherine J Wu.
Cancer J, 2017 Apr 15; 23(2). PMID: 28410299    Free PMC article.
Dendritic Cell Strategies for Eliciting Mutation-Derived Tumor Antigen Responses in Patients.
Sreekumar Balan, John Finnigan, Nina Bhardwaj.
Cancer J, 2017 Apr 15; 23(2). PMID: 28410301    Free PMC article.
Immune Checkpoint Inhibitors for Brain Metastases.
Aaron C Tan, Amy B Heimberger, +2 authors, Mustafa Khasraw.
Curr Oncol Rep, 2017 Apr 19; 19(6). PMID: 28417311
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.
Zachary R Chalmers, Caitlin F Connelly, +21 authors, Garrett M Frampton.
Genome Med, 2017 Apr 20; 9(1). PMID: 28420421    Free PMC article.
Highly Cited.
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.
Melita Irving, Romain Vuillefroy de Silly, +2 authors, George Coukos.
Front Immunol, 2017 Apr 20; 8. PMID: 28421069    Free PMC article.
[The pathology of adverse events with immune checkpoint inhibitors].
V H Koelzer, K Glatz, +7 authors, K D Mertz.
Pathologe, 2017 Apr 20; 38(3). PMID: 28421272
Multi-omics study revealing the complexity and spatial heterogeneity of tumor-infiltrating lymphocytes in primary liver carcinoma.
Lijun Shi, Yang Zhang, +6 authors, Shujun Cheng.
Oncotarget, 2017 Apr 20; 8(21). PMID: 28422742    Free PMC article.
HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model.
Barbara Schrörs, Silke Lübcke, +8 authors, Thomas Wölfel.
Oncotarget, 2017 Apr 21; 8(17). PMID: 28423700    Free PMC article.
Immunotherapy and targeted therapy in brain metastases: emerging options in precision medicine.
Tyler Lazaro, Priscilla K Brastianos.
CNS Oncol, 2017 Apr 21; 6(2). PMID: 28425754    Free PMC article.
The use of immunotherapy in the treatment of melanoma.
Tala Achkar, Ahmad A Tarhini.
J Hematol Oncol, 2017 Apr 25; 10(1). PMID: 28434398    Free PMC article.
Spotlight on nivolumab in the treatment of renal cell carcinoma: design, development, and place in therapy.
Vyshak Alva Venur, Monika Joshi, Kenneth G Nepple, Yousef Zakharia.
Drug Des Devel Ther, 2017 Apr 27; 11. PMID: 28442891    Free PMC article.
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.
Kole T Roybal, Wendell A Lim.
Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446063    Free PMC article.
Landscape of Combination Immunotherapy and Targeted Therapy to Improve Cancer Management.
Leandro M Colli, Mitchell J Machiela, +5 authors, Stephen J Chanock.
Cancer Res, 2017 Apr 28; 77(13). PMID: 28446466    Free PMC article.
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients.
Alice O Kamphorst, Rathi N Pillai, +16 authors, Suresh S Ramalingam.
Proc Natl Acad Sci U S A, 2017 Apr 28; 114(19). PMID: 28446615    Free PMC article.
Highly Cited.
Association of CTLA-4 Gene Variants with Response to Therapy and Long-term Survival in Metastatic Melanoma Patients Treated with Ipilimumab: An Italian Melanoma Intergroup Study.
Paola Queirolo, Beatrice Dozin, +28 authors, Maria Pia Pistillo.
Front Immunol, 2017 Apr 28; 8. PMID: 28446908    Free PMC article.
Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal.
P A Ott, S A Piha-Paul, +13 authors, J Bennouna.
Ann Oncol, 2017 Apr 30; 28(5). PMID: 28453692    Free PMC article.
Highly Cited.
T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas.
Seth M Pollack, Qianchuan He, +21 authors, Robin L Jones.
Cancer, 2017 May 04; 123(17). PMID: 28463396    Free PMC article.
Highly Cited.
Human Tumor Antigens Yesterday, Today, and Tomorrow.
Olivera J Finn.
Cancer Immunol Res, 2017 May 04; 5(5). PMID: 28465452    Free PMC article.
Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model.
Kyoung-Jin Kim, Ji-Hye Kim, +3 authors, Jinsil Seong.
Oncotarget, 2017 May 04; 8(25). PMID: 28465485    Free PMC article.
Academic, Foundation, and Industry Collaboration in Finding New Therapies.
Bonnie W Ramsey, Gerald T Nepom, Sagar Lonial.
N Engl J Med, 2017 May 04; 376(18). PMID: 28467868    Free PMC article.
Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study.
Jung-Min Lee, Ashley Cimino-Mathews, +16 authors, Elise C Kohn.
J Clin Oncol, 2017 May 05; 35(19). PMID: 28471727    Free PMC article.
Highly Cited.
Current status of chimeric antigen receptor engineered T cell-based and immune checkpoint blockade-based cancer immunotherapies.
Upendra P Hegde, Bijay Mukherji.
Cancer Immunol Immunother, 2017 May 13; 66(9). PMID: 28497159    Free PMC article.
Phase I clinical trial of cell division associated 1 (CDCA1) peptide vaccination for castration resistant prostate cancer.
Wataru Obara, Fuminori Sato, +8 authors, Tomoaki Fujioka.
Cancer Sci, 2017 May 13; 108(7). PMID: 28498618    Free PMC article.
Immunotherapy for the Treatment of Uveal Melanoma: Current Status and Emerging Therapies.
Kimberly M Komatsubara, Richard D Carvajal.
Curr Oncol Rep, 2017 May 17; 19(7). PMID: 28508938
Mechanisms of Immune Tolerance in Leukemia and Lymphoma.
Emily K Curran, James Godfrey, Justin Kline.
Trends Immunol, 2017 May 18; 38(7). PMID: 28511816    Free PMC article.
Genetic load makes cancer cells more sensitive to common drugs: evidence from Cancer Cell Line Encyclopedia.
Ana B Pavel, Kirill S Korolev.
Sci Rep, 2017 May 18; 7(1). PMID: 28512298    Free PMC article.
Chromatin states define tumour-specific T cell dysfunction and reprogramming.
Mary Philip, Lauren Fairchild, +11 authors, Andrea Schietinger.
Nature, 2017 May 18; 545(7655). PMID: 28514453    Free PMC article.
Highly Cited.
Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy.
Sacha Gnjatic, Vincenzo Bronte, +13 authors, Lisa H Butterfield.
J Immunother Cancer, 2017 May 19; 5. PMID: 28515944    Free PMC article.
Highly Cited. Review.
Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1.
Elizabeth A McNiel, Philip N Tsichlis.
Signal Transduct Target Ther, 2017 May 19; 2. PMID: 28515962    Free PMC article.
Hallmarks of response to immune checkpoint blockade.
Alexandria P Cogdill, Miles C Andrews, Jennifer A Wargo.
Br J Cancer, 2017 May 20; 117(1). PMID: 28524159    Free PMC article.
Highly Cited. Review.
Immunogenomics: using genomics to personalize cancer immunotherapy.
Rance C Siniard, Shuko Harada.
Virchows Arch, 2017 May 22; 471(2). PMID: 28528510
Clinical experiences of combining immunotherapy and radiation therapy in non-small cell lung cancer: lessons from melanoma.
Anusha Kalbasi, Ramesh Rengan.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529899    Free PMC article.
HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.
Vitaly Kochin, Takayuki Kanaseki, +11 authors, Toshihiko Torigoe.
Oncoimmunology, 2017 May 24; 6(4). PMID: 28533942    Free PMC article.
The Damaging Effect of Passenger Mutations on Cancer Progression.
Christopher D McFarland, Julia A Yaglom, +4 authors, Leonid A Mirny.
Cancer Res, 2017 May 26; 77(18). PMID: 28536279    Free PMC article.
Immune signature of metastatic breast cancer: Identifying predictive markers of immunotherapy response.
Ji-Yeon Kim, Eunjin Lee, +5 authors, Yeon Hee Park.
Oncotarget, 2017 May 26; 8(29). PMID: 28537889    Free PMC article.
Therapeutic T cell engineering.
Michel Sadelain, Isabelle Rivière, Stanley Riddell.
Nature, 2017 May 26; 545(7655). PMID: 28541315    Free PMC article.
Highly Cited. Review.
Immune and molecular correlates in melanoma treated with immune checkpoint blockade.
Elizabeth H Byrne, David E Fisher.
Cancer, 2017 May 26; 123(S11). PMID: 28543699    Free PMC article.
Interaction of molecular alterations with immune response in melanoma.
Robert A Szczepaniak Sloane, Vancheswaran Gopalakrishnan, +3 authors, Jennifer A Wargo.
Cancer, 2017 May 26; 123(S11). PMID: 28543700    Free PMC article.
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis.
Alexandra Snyder, Tavi Nathanson, +18 authors, Dean F Bajorin.
PLoS Med, 2017 May 30; 14(5). PMID: 28552987    Free PMC article.
Highly Cited.
The Transcriptional Landscape of p53 Signalling Pathway.
Chizu Tanikawa, Yao-Zhong Zhang, +10 authors, Koichi Matsuda.
EBioMedicine, 2017 Jun 01; 20. PMID: 28558959    Free PMC article.
Immunotherapy in head and neck cancer: aiming at EXTREME precision.
Petr Szturz, Jan B Vermorken.
BMC Med, 2017 Jun 03; 15(1). PMID: 28571578    Free PMC article.
Immunotherapy for Breast Cancer: What Are We Missing?
Robert H Vonderheide, Susan M Domchek, Amy S Clark.
Clin Cancer Res, 2017 Jun 03; 23(11). PMID: 28572258    Free PMC article.
Highly Cited.
A molecular portrait of microsatellite instability across multiple cancers.
Isidro Cortes-Ciriano, Sejoon Lee, +2 authors, Peter J Park.
Nat Commun, 2017 Jun 07; 8. PMID: 28585546    Free PMC article.
Highly Cited.
Systematic genomic and translational efficiency studies of uveal melanoma.
Chelsea Place Johnson, Ivana K Kim, +19 authors, Scott E Woodman.
PLoS One, 2017 Jun 09; 12(6). PMID: 28594900    Free PMC article.
Identifying "super responders" in pulmonary arterial hypertension.
Stephen J Halliday, Anna R Hemnes.
Pulm Circ, 2017 Jun 10; 7(2). PMID: 28597766    Free PMC article.
New insights into the role of EMT in tumor immune escape.
Stéphane Terry, Pierre Savagner, +4 authors, Salem Chouaib.
Mol Oncol, 2017 Jun 15; 11(7). PMID: 28614624    Free PMC article.
Highly Cited. Review.
Phase II Study of Adjuvant Immunotherapy with the CSF-470 Vaccine Plus Bacillus Calmette-Guerin Plus Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor vs Medium-Dose Interferon Alpha 2B in Stages IIB, IIC, and III Cutaneous Melanoma Patients: A Single Institution, Randomized Study.
José Mordoh, María Betina Pampena, +11 authors, María Marcela Barrio.
Front Immunol, 2017 Jun 18; 8. PMID: 28620382    Free PMC article.
Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies.
Jeong A Park, Nai-Kong V Cheung.
Cancer Treat Rev, 2017 Jun 18; 58. PMID: 28622628    Free PMC article.
DNA Damage and Repair Biomarkers of Immunotherapy Response.
Kent W Mouw, Michael S Goldberg, Panagiotis A Konstantinopoulos, Alan D D'Andrea.
Cancer Discov, 2017 Jun 21; 7(7). PMID: 28630051    Free PMC article.
Highly Cited. Review.
Systems immunology: just getting started.
Mark M Davis, Cristina M Tato, David Furman.
Nat Immunol, 2017 Jun 21; 18(7). PMID: 28632713    Free PMC article.
Highly Cited. Review.
Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors.
Keisuke Fujii, Yoshihiro Miyahara, +10 authors, Hiroshi Shiku.
Oncoimmunology, 2017 Jun 24; 6(5). PMID: 28638727    Free PMC article.
Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.
Maher G Nawaf, Maria H Ulvmar, +7 authors, Peter J L Lane.
J Immunol, 2017 Jun 25; 199(3). PMID: 28646041    Free PMC article.
Immunotherapy biomarkers 2016: overcoming the barriers.
James L Gulley, Jay A Berzofsky, +18 authors, Lisa H Butterfield.
J Immunother Cancer, 2017 Jun 28; 5(1). PMID: 28653584    Free PMC article.
Monitoring immune-checkpoint blockade: response evaluation and biomarker development.
Mizuki Nishino, Nikhil H Ramaiya, Hiroto Hatabu, F Stephen Hodi.
Nat Rev Clin Oncol, 2017 Jun 28; 14(11). PMID: 28653677    Free PMC article.
Highly Cited. Review.
IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.
Christopher J Nirschl, Mayte Suárez-Fariñas, +26 authors, Niroshana Anandasabapathy.
Cell, 2017 Jul 01; 170(1). PMID: 28666115    Free PMC article.
Highly Cited.
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.
Ugur Sahin, Evelyna Derhovanessian, +47 authors, Özlem Türeci.
Nature, 2017 Jul 06; 547(7662). PMID: 28678784
Highly Cited.
Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression.
Julian P Layer, Marie T Kronmüller, +13 authors, Michael Hölzel.
Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680756    Free PMC article.
Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: A pilot study.
Yong Qin, Mariana Petaccia de Macedo, +24 authors, Sapna P Patel.
Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680759    Free PMC article.
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.
Stephanie R Barbari, Polina V Shcherbakova.
DNA Repair (Amst), 2017 Jul 09; 56. PMID: 28687338    Free PMC article.
Oncolytic viruses: adenoviruses.
Julia Niemann, Florian Kühnel.
Virus Genes, 2017 Jul 14; 53(5). PMID: 28702840
A perspective on the impact of radiation therapy on the immune rheostat.
William H McBride, Ekambaram Ganapathy, +3 authors, Dörthe Schaue.
Br J Radiol, 2017 Jul 15; 90(1078). PMID: 28707537    Free PMC article.
Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy.
Kimberly Loo, Katy K Tsai, +14 authors, Adil I Daud.
JCI Insight, 2017 Jul 21; 2(14). PMID: 28724802    Free PMC article.
The 'Pushmi-Pullyu' of DNA REPAIR: Clinical Synthetic Lethality.
S Percy Ivy, Johann de Bono, Elise C Kohn.
Trends Cancer, 2017 Jul 26; 2(11). PMID: 28741503    Free PMC article.
The immune contexture in cancer prognosis and treatment.
Wolf H Fridman, Laurence Zitvogel, Catherine Sautès-Fridman, Guido Kroemer.
Nat Rev Clin Oncol, 2017 Jul 26; 14(12). PMID: 28741618
Highly Cited. Review.
Treatment Outcomes for Metastatic Melanoma of Unknown Primary in the New Era: A Single-Institution Study and Review of the Literature.
Kierstin Utter, Chloe Goldman, +5 authors, Iman Osman.
Oncology, 2017 Jul 27; 93(4). PMID: 28746931    Free PMC article.
Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors.
Nathan O Siemers, James L Holloway, +4 authors, Joseph D Szustakowski.
PLoS One, 2017 Jul 28; 12(7). PMID: 28749946    Free PMC article.
The Landscape of Whole-genome Alterations and Pathologic Features in Genitourinary Malignancies: An Analysis of the Cancer Genome Atlas.
Mark W Ball, Michael A Gorin, +2 authors, Mohamad E Allaf.
Eur Urol Focus, 2017 Jul 30; 3(6). PMID: 28753846    Free PMC article.
Tools to define the melanoma-associated immunopeptidome.
Eva Bräunlein, Angela M Krackhardt.
Immunology, 2017 Jul 30; 152(4). PMID: 28755382    Free PMC article.
Mismatch Repair Deficiency as a Predictive Biomarker for Immunotherapy Efficacy.
Giulia Viale, Dario Trapani, Giuseppe Curigliano.
Biomed Res Int, 2017 Aug 05; 2017. PMID: 28770222    Free PMC article.
Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma.
Russell Maxwell, Christopher M Jackson, Michael Lim.
Curr Treat Options Oncol, 2017 Aug 09; 18(8). PMID: 28785997
Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma.
Wenyong Long, Yang Yi, +3 authors, Qing Liu.
Front Pharmacol, 2017 Aug 10; 8. PMID: 28790919    Free PMC article.
Breast Cancer Immunotherapy: Facts and Hopes.
Leisha A Emens.
Clin Cancer Res, 2017 Aug 13; 24(3). PMID: 28801472    Free PMC article.
Highly Cited. Review.
Lung tumor exome files with T-cell receptor recombinations: a mouse model of T-cell infiltrates reflecting mutation burdens.
Yaping N Tu, Wei Lue Tong, Timothy J Fawcett, George Blanck.
Lab Invest, 2017 Aug 15; 97(12). PMID: 28805806
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma.
Alexandre Reuben, Christine N Spencer, +51 authors, Jennifer A Wargo.
NPJ Genom Med, 2017 Aug 19; 2. PMID: 28819565    Free PMC article.
Highly Cited.
Immune Dysfunction in Non-Hodgkin Lymphoma: Avenues for New Immunotherapy-Based Strategies.
Lorenzo Falchi.
Curr Hematol Malig Rep, 2017 Aug 20; 12(5). PMID: 28822058
Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making.
Wassim Abida, Joshua Armenia, +38 authors, Howard I Scher.
JCO Precis Oncol, 2017 Aug 22; 2017. PMID: 28825054    Free PMC article.
Highly Cited.
Optimizing tumor immune response through combination of radiation and immunotherapy.
Alissar El Chediak, Ali Shamseddine, +3 authors, Youssef H Zeidan.
Med Oncol, 2017 Aug 23; 34(9). PMID: 28828581
Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.
Aaron M Goodman, Shumei Kato, +6 authors, Razelle Kurzrock.
Mol Cancer Ther, 2017 Aug 25; 16(11). PMID: 28835386    Free PMC article.
Highly Cited.
CIMT 2017: Anniversary symposium - Report on the 15th CIMT Annual Meeting of the Association for Cancer Immunotherapy.
Lena M Kranz, Jan D Beck, +3 authors, Mustafa Diken.
Hum Vaccin Immunother, 2017 Aug 29; 13(10). PMID: 28846471    Free PMC article.
Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors.
Carmelo Tibaldi, Alice Lunghi, Editta Baldini.
World J Clin Oncol, 2017 Aug 30; 8(4). PMID: 28848698    Free PMC article.
The neoepitope landscape in pediatric cancers.
Ti-Cheng Chang, Robert A Carter, +13 authors, Jinghui Zhang.
Genome Med, 2017 Sep 01; 9(1). PMID: 28854978    Free PMC article.
Glioblastoma targeted therapy: updated approaches from recent biological insights.
M Touat, A Idbaih, M Sanson, K L Ligon.
Ann Oncol, 2017 Sep 03; 28(7). PMID: 28863449    Free PMC article.
Highly Cited. Review.
Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity.
Valsamo Anagnostou, Mark Yarchoan, +6 authors, Patrick M Forde.
Clin Cancer Res, 2017 Sep 03; 23(17). PMID: 28864724    Free PMC article.
From Famine to Feast: Developing Early-Phase Combination Immunotherapy Trials Wisely.
Daphne Day, Arta M Monjazeb, +4 authors, Marcus O Butler.
Clin Cancer Res, 2017 Sep 03; 23(17). PMID: 28864726    Free PMC article.
Immune checkpoint inhibitors in cancer therapy.
Eika S Webb, Peng Liu, +3 authors, Yao-He Wang.
J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656    Free PMC article.
The immunologic advantage of recurrent nasopharyngeal carcinoma from the viewpoint of Galectin-9/Tim-3-related changes in the tumour microenvironment.
Tseng-Cheng Chen, Chao-Hsien Chen, +6 authors, Yih-Leong Chang.
Sci Rep, 2017 Sep 06; 7(1). PMID: 28871094    Free PMC article.
Therapeutic vaccine to cure large mouse hepatocellular carcinomas.
Zhen Han, De Yang, Anna Trivett, Joost J Oppenheim.
Oncotarget, 2017 Sep 09; 8(32). PMID: 28881713    Free PMC article.
Clinical application of a cancer genomic profiling assay to guide precision medicine decisions.
Cheryl Eifert, Angeliki Pantazi, +9 authors, Alexei Protopopov.
Per Med, 2017 Sep 12; 14(4). PMID: 28890729    Free PMC article.
Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care.
Mizuki Nishino, Hiroto Hatabu, Lynette M Sholl, Nikhil H Ramaiya.
Radiographics, 2017 Sep 13; 37(5). PMID: 28898185    Free PMC article.
Neoantigen prediction and the need for validation.
Antonella Vitiello, Maurizio Zanetti.
Nat Biotechnol, 2017 Sep 13; 35(9). PMID: 28898209
Targeting Neoantigens in Glioblastoma: An Overview of Cancer Immunogenomics and Translational Implications.
Tanner M Johanns, Jay A Bowman-Kirigin, Connor Liu, Gavin P Dunn.
Neurosurgery, 2017 Sep 14; 64(CN_suppl_1). PMID: 28899059    Free PMC article.
Classifying the evolutionary and ecological features of neoplasms.
Carlo C Maley, Athena Aktipis, +19 authors, Darryl Shibata.
Nat Rev Cancer, 2017 Sep 16; 17(10). PMID: 28912577    Free PMC article.
Highly Cited. Review.
Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells.
M Fehlings, Y Simoni, +7 authors, E W Newell.
Nat Commun, 2017 Sep 17; 8(1). PMID: 28916749    Free PMC article.
Emerging biomarkers for cancer immunotherapy in melanoma.
Margaret L Axelrod, Douglas B Johnson, Justin M Balko.
Semin Cancer Biol, 2017 Sep 18; 52(Pt 2). PMID: 28917578    Free PMC article.
First report of clinical responses to immunotherapy in 3 relapsing cases of chordoma after failure of standard therapies.
Denis Migliorini, Nicolas Mach, +6 authors, Pierre-Yves Dietrich.
Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28919999    Free PMC article.
The frequency of neoantigens per somatic mutation rather than overall mutational load or number of predicted neoantigens per se is a prognostic factor in ovarian clear cell carcinoma.
Hirokazu Matsushita, Kosei Hasegawa, +9 authors, Kazuhiro Kakimi.
Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28920005    Free PMC article.
Dosing immunotherapy combinations: Analysis of 3,526 patients for toxicity and response patterns.
Mina Nikanjam, Harsh Patel, Razelle Kurzrock.
Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28920006    Free PMC article.
Relationship of tumor PD-L1 (CD274) expression with lower mortality in lung high-grade neuroendocrine tumor.
Kentaro Inamura, Yusuke Yokouchi, +5 authors, Yuichi Ishikawa.
Cancer Med, 2017 Sep 20; 6(10). PMID: 28925087    Free PMC article.
Predictors of responses to immune checkpoint blockade in advanced melanoma.
N Jacquelot, M P Roberti, +47 authors, L Zitvogel.
Nat Commun, 2017 Sep 21; 8(1). PMID: 28928380    Free PMC article.
Highly Cited.
New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification.
Joakim Crona, David Taïeb, Karel Pacak.
Endocr Rev, 2017 Sep 25; 38(6). PMID: 28938417    Free PMC article.
Highly Cited. Review.
Mitochondrial Metabolism: Yin and Yang for Tumor Progression.
Lorea Valcarcel-Jimenez, Edoardo Gaude, +2 authors, Arkaitz Carracedo.
Trends Endocrinol Metab, 2017 Sep 25; 28(10). PMID: 28938972    Free PMC article.
Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.
Henrik Jespersen, Mattias F Lindberg, +7 authors, Jonas A Nilsson.
Nat Commun, 2017 Sep 29; 8(1). PMID: 28955032    Free PMC article.
The Potential and Challenges of Exploiting the Vast But Dynamic Neoepitope Landscape for Immunotherapy.
Els M E Verdegaal, Sjoerd H van der Burg.
Front Immunol, 2017 Sep 30; 8. PMID: 28959257    Free PMC article.
Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters.
M Linch, G Goh, +31 authors, C Swanton.
Ann Oncol, 2017 Sep 30; 28(10). PMID: 28961847    Free PMC article.
Hypermutated Circulating Tumor DNA: Correlation with Response to Checkpoint Inhibitor-Based Immunotherapy.
Yulian Khagi, Aaron M Goodman, +5 authors, Razelle Kurzrock.
Clin Cancer Res, 2017 Oct 04; 23(19). PMID: 28972084    Free PMC article.
Highly Cited.
Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF.
Andrea J Manrique-Rincón, Camila M Beraldo, Jessica M Toscaro, Marcio C Bajgelman.
Front Immunol, 2017 Oct 05; 8. PMID: 28974950    Free PMC article.
Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer.
Tao Shen, Zhengming Chen, Zhizhuang Joe Zhao, Jie Wu.
Oncotarget, 2017 Oct 06; 8(37). PMID: 28977839    Free PMC article.
Towards a better cancer precision medicine: systems biology meets immunotherapy.
Bhavneet Bhinder, Olivier Elemento.
Curr Opin Syst Biol, 2017 Oct 11; 2. PMID: 28989987    Free PMC article.
The diverse functions of the PD1 inhibitory pathway.
Arlene H Sharpe, Kristen E Pauken.
Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585
Highly Cited. Review.
Cholangiocarcinoma - evolving concepts and therapeutic strategies.
Sumera Rizvi, Shahid A Khan, +2 authors, Gregory J Gores.
Nat Rev Clin Oncol, 2017 Oct 11; 15(2). PMID: 28994423    Free PMC article.
Highly Cited. Review.
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer.
Scott Gettinger, Jungmin Choi, +23 authors, Katerina Politi.
Cancer Discov, 2017 Oct 14; 7(12). PMID: 29025772    Free PMC article.
Highly Cited.
Challenging the standard of care in advanced melanoma: focus on pembrolizumab.
Raghad M Abdul-Karim, C Lance Cowey.
Cancer Manag Res, 2017 Oct 14; 9. PMID: 29026335    Free PMC article.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth.
Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Norman Woller.
Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503    Free PMC article.
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.
Nadeem Riaz, Jonathan J Havel, +22 authors, Timothy A Chan.
Cell, 2017 Oct 17; 171(4). PMID: 29033130    Free PMC article.
Highly Cited.
Biomarkers for Response of Melanoma Patients to Immune Checkpoint Inhibitors: A Systematic Review.
Charissa A C Jessurun, Julien A M Vos, Jacqueline Limpens, Rosalie M Luiten.
Front Oncol, 2017 Oct 17; 7. PMID: 29034210    Free PMC article.
Clinical and molecular characterization of patients with cancer of unknown primary in the modern era.
A M Varghese, A Arora, +12 authors, L B Saltz.
Ann Oncol, 2017 Oct 19; 28(12). PMID: 29045506    Free PMC article.
Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.
Tamson Moore, Courtney Regan Wagner, +23 authors, Michael I Nishimura.
Cancer Immunol Immunother, 2017 Oct 21; 67(2). PMID: 29052782    Free PMC article.
Comprehensive Analysis of Hypermutation in Human Cancer.
Brittany B Campbell, Nicholas Light, +59 authors, Adam Shlien.
Cell, 2017 Oct 24; 171(5). PMID: 29056344    Free PMC article.
Highly Cited.
Beyond PD-L1 testing-emerging biomarkers for immunotherapy in non-small cell lung cancer.
Khinh Ranh Voong, Josephine Feliciano, Daniel Becker, Benjamin Levy.
Ann Transl Med, 2017 Oct 24; 5(18). PMID: 29057236    Free PMC article.
Emerging uses of circulating tumor DNA in advanced stage non-small cell lung cancer.
Melina Marmarelis, Jeffrey C Thompson, +5 authors, Joshua Bauml.
Ann Transl Med, 2017 Oct 24; 5(18). PMID: 29057240    Free PMC article.
Immunotherapy for Pediatric Brain Tumors.
Elias J Sayour, Duane A Mitchell.
Brain Sci, 2017 Oct 27; 7(10). PMID: 29065490    Free PMC article.
T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.
Ingunn M Stromnes, Ayaka Hulbert, +2 authors, Sunil R Hingorani.
Cancer Immunol Res, 2017 Oct 27; 5(11). PMID: 29066497    Free PMC article.
Highly Cited.
Resistance to checkpoint blockade therapy through inactivation of antigen presentation.
Moshe Sade-Feldman, Yunxin J Jiao, +28 authors, Nir Hacohen.
Nat Commun, 2017 Oct 27; 8(1). PMID: 29070816    Free PMC article.
Highly Cited.
Immunotherapy regimens for metastatic colorectal carcinomas.
Babar Bashir, Adam E Snook.
Hum Vaccin Immunother, 2017 Oct 31; 14(2). PMID: 29083978    Free PMC article.
Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.
Martin G Dalin, Nora Katabi, +19 authors, Luc G T Morris.
Nat Commun, 2017 Nov 01; 8(1). PMID: 29084941    Free PMC article.
Expression differences of programmed death ligand 1 in de-novo and recurrent glioblastoma multiforme.
Sabrina Heynckes, Annette Gaebelein, +8 authors, Dieter Henrik Heiland.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088776    Free PMC article.
Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma.
Hilary R Keller, Xin Zhang, +2 authors, James W Wells.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088901    Free PMC article.
Effects of Co-occurring Genomic Alterations on Outcomes in Patients with KRAS-Mutant Non-Small Cell Lung Cancer.
Kathryn C Arbour, Emmett Jordan, +13 authors, Gregory J Riely.
Clin Cancer Res, 2017 Nov 02; 24(2). PMID: 29089357    Free PMC article.
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.
V Gopalakrishnan, C N Spencer, +67 authors, J A Wargo.
Science, 2017 Nov 04; 359(6371). PMID: 29097493    Free PMC article.
Highly Cited.
Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles.
Klaus G Griewank, Thomas Wiesner, +12 authors, Thomas Mentzel.
Mod Pathol, 2017 Nov 04; 31(3). PMID: 29099504    Free PMC article.
Cancer Evolution during Immunotherapy.
M C Andrews, J A Wargo.
Cell, 2017 Nov 04; 171(4). PMID: 29100071    Free PMC article.
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.
Nicholas McGranahan, Rachel Rosenthal, +9 authors, TRACERx Consortium.
Cell, 2017 Nov 07; 171(6). PMID: 29107330    Free PMC article.
Highly Cited.
New trends in antitumor vaccines in melanoma.
Marcos Vasquez, Shirley Tenesaca, Pedro Berraondo.
Ann Transl Med, 2017 Nov 09; 5(19). PMID: 29114542    Free PMC article.
Predictive factors of response to immunotherapy-a review from the Spanish Melanoma Group (GEM).
Enrique Espinosa, Ivan Márquez-Rodas, +5 authors, Spanish Melanoma Group (GEM).
Ann Transl Med, 2017 Nov 09; 5(19). PMID: 29114547    Free PMC article.
Combining DNA damaging therapeutics with immunotherapy: more haste, less speed.
Jessica S Brown, Raghav Sundar, Juanita Lopez.
Br J Cancer, 2017 Nov 11; 118(3). PMID: 29123260    Free PMC article.
Highly Cited. Review.
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma.
Ayman Oweida, Shelby Lennon, +11 authors, Sana D Karam.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123967    Free PMC article.
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy.
Marta Łuksza, Nadeem Riaz, +9 authors, Benjamin D Greenbaum.
Nature, 2017 Nov 14; 551(7681). PMID: 29132144    Free PMC article.
Highly Cited.
Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer.
Anna E Kersh, Spencer Ng, +7 authors, Brian P Pollack.
J Clin Pharmacol, 2017 Nov 15; 58(1). PMID: 29136276    Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer.
R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs.
Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554    Free PMC article.
Future perspectives in melanoma research "Melanoma Bridge", Napoli, November 30th-3rd December 2016.
Paolo A Ascierto, Sanjiv S Agarwala, +20 authors, Magdalena Thurin.
J Transl Med, 2017 Nov 18; 15(1). PMID: 29145885    Free PMC article.
Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4.
Xuan Mo, Hanghang Zhang, +7 authors, M Raza Zaidi.
Cancer Res, 2017 Nov 19; 78(2). PMID: 29150430    Free PMC article.
Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells.
Ugo Testa, Germana Castelli, Elvira Pelosi.
Med Sci (Basel), 2017 Nov 22; 5(4). PMID: 29156643    Free PMC article.
Biomarkers for immunotherapy in bladder cancer: a moving target.
David H Aggen, Charles G Drake.
J Immunother Cancer, 2017 Nov 22; 5(1). PMID: 29157296    Free PMC article.
Impressive response to immunotherapy in a metastatic gastric cancer patient: could somatic copy number alterations help patient selection?
Gustavo Dos Santos Fernandes, Daniel da Motta Girardi, +2 authors, Renata de Almeida Coudry.
J Immunother Cancer, 2017 Nov 22; 5(1). PMID: 29157298    Free PMC article.
Whole exome sequencing for determination of tumor mutation load in liquid biopsy from advanced cancer patients.
Florence Koeppel, Steven Blanchard, +8 authors, Ludovic Lacroix.
PLoS One, 2017 Nov 22; 12(11). PMID: 29161279    Free PMC article.
Checkpoint inhibitors in endometrial cancer: preclinical rationale and clinical activity.
Gloria Mittica, Eleonora Ghisoni, +3 authors, Giorgio Valabrega.
Oncotarget, 2017 Nov 23; 8(52). PMID: 29163851    Free PMC article.
Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles.
Alberto Grandi, Michele Tomasi, +14 authors, Guido Grandi.
Front Oncol, 2017 Nov 23; 7. PMID: 29164053    Free PMC article.
Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma.
Martin Lauss, Marco Donia, +10 authors, Göran Jönsson.
Nat Commun, 2017 Nov 25; 8(1). PMID: 29170503    Free PMC article.
Highly Cited.
An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors.
Yong-Chen Lu, Zhili Zheng, +9 authors, Steven A Rosenberg.
Mol Ther, 2017 Nov 28; 26(2). PMID: 29174843    Free PMC article.
Targeting immune checkpoints in breast cancer: an update of early results.
Cinzia Solinas, Andrea Gombos, +3 authors, Laurence Buisseret.
ESMO Open, 2017 Nov 28; 2(5). PMID: 29177095    Free PMC article.
Metastatic melanoma patients' sensitivity to ipilimumab cannot be predicted by tumor characteristics.
Kara Rossfeld, Erinn M Hade, +8 authors, Georgia M Beasley.
Int J Surg Oncol (N Y), 2017 Nov 28; 2(9). PMID: 29177235    Free PMC article.
Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells.
Nils-Petter Rudqvist, Karsten A Pilones, +7 authors, Sandra Demaria.
Cancer Immunol Res, 2017 Nov 29; 6(2). PMID: 29180535    Free PMC article.
Uncommon BRAF Mutations Associated with Durable Response to Immunotherapy in Patients with Metastatic Melanoma.
Brenen P Swofford, Jade Homsi.
Case Rep Oncol Med, 2017 Nov 29; 2017. PMID: 29181212    Free PMC article.
An Analysis of Natural T Cell Responses to Predicted Tumor Neoepitopes.
Anne-Mette Bjerregaard, Morten Nielsen, +4 authors, Aron Charles Eklund.
Front Immunol, 2017 Dec 01; 8. PMID: 29187854    Free PMC article.
Implications of the tumor immune microenvironment for staging and therapeutics.
Janis M Taube, Jérôme Galon, +8 authors, Ashley Cimino-Mathews.
Mod Pathol, 2017 Dec 02; 31(2). PMID: 29192647    Free PMC article.
Highly Cited. Review.
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy.
Diego Chowell, Luc G T Morris, +17 authors, Timothy A Chan.
Science, 2017 Dec 09; 359(6375). PMID: 29217585    Free PMC article.
Highly Cited.
Drug development in the era of precision medicine.
Sarah A Dugger, Adam Platt, David B Goldstein.
Nat Rev Drug Discov, 2017 Dec 09; 17(3). PMID: 29217837    Free PMC article.
Highly Cited. Review.
Towards personalized, tumour-specific, therapeutic vaccines for cancer.
Zhuting Hu, Patrick A Ott, Catherine J Wu.
Nat Rev Immunol, 2017 Dec 12; 18(3). PMID: 29226910    Free PMC article.
Highly Cited. Review.
Navigating the "No Man's Land" of TKI-Failed EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC): A Review.
Bryan Oronsky, Patrick Ma, +5 authors, Corey A Carter.
Neoplasia, 2017 Dec 12; 20(1). PMID: 29227909    Free PMC article.
Nanoparticulate Delivery of Cancer Cell Membrane Elicits Multiantigenic Antitumor Immunity.
Ashley V Kroll, Ronnie H Fang, +8 authors, Liangfang Zhang.
Adv Mater, 2017 Dec 15; 29(47). PMID: 29239517    Free PMC article.
Molecular Biomarkers of Primary and Acquired Resistance to T-Cell-Mediated Immunotherapy in Cancer: Landscape, Clinical Implications, and Future Directions.
Young Kwang Chae, Michael S Oh, Francis J Giles.
Oncologist, 2017 Dec 16; 23(4). PMID: 29242279    Free PMC article.
Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma.
Tatenda Mahlokozera, Ananth K Vellimana, +10 authors, Albert H Kim.
Neuro Oncol, 2017 Dec 16; 20(4). PMID: 29244145    Free PMC article.
Synergy of Immune Checkpoint Blockade with a Novel Synthetic Consensus DNA Vaccine Targeting TERT.
Elizabeth K Duperret, Megan C Wise, +8 authors, David B Weiner.
Mol Ther, 2017 Dec 19; 26(2). PMID: 29249395    Free PMC article.
Identification and Characterization of Neoantigens As Well As Respective Immune Responses in Cancer Patients.
Eva Bräunlein, Angela M Krackhardt.
Front Immunol, 2017 Dec 19; 8. PMID: 29250075    Free PMC article.
Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions.
Hsiu-Chuan Wei, Jui-Ling Yu, Chia-Yu Hsu.
Comput Math Methods Med, 2017 Dec 19; 2017. PMID: 29250133    Free PMC article.
Preclinical and clinical development of neoantigen vaccines.
L Li, S P Goedegebuure, W E Gillanders.
Ann Oncol, 2017 Dec 19; 28(suppl_12). PMID: 29253113    Free PMC article.
Informatics for cancer immunotherapy.
J Hammerbacher, A Snyder.
Ann Oncol, 2017 Dec 19; 28(suppl_12). PMID: 29253114    Free PMC article.
Understanding preanalytical variables and their effects on clinical biomarkers of oncology and immunotherapy.
Lokesh Agrawal, Kelly B Engel, Sarah R Greytak, Helen M Moore.
Semin Cancer Biol, 2017 Dec 21; 52(Pt 2). PMID: 29258857    Free PMC article.
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer.
David Liu, Philip Abbosh, +22 authors, Eliezer M Van Allen.
Nat Commun, 2017 Dec 21; 8(1). PMID: 29259186    Free PMC article.
Shared cancer neoantigens: Making private matters public.
Christopher A Klebanoff, Jedd D Wolchok.
J Exp Med, 2017 Dec 23; 215(1). PMID: 29269561    Free PMC article.
The Positive Relationship Between γH2AX and PD-L1 Expression in Lung Squamous Cell Carcinoma.
Atsushi Osoegawa, Hitomi Hiraishi, +6 authors, Kenji Sugio.
In Vivo, 2017 Dec 25; 32(1). PMID: 29275316    Free PMC article.
Chemo-Immunotherapy: Role of Indoleamine 2,3-Dioxygenase in Defining Immunogenic Versus Tolerogenic Cell Death in the Tumor Microenvironment.
Theodore S Johnson, Tracy Mcgaha, David H Munn.
Adv Exp Med Biol, 2017 Dec 25; 1036. PMID: 29275467    Free PMC article.
Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells.
Michael P Plebanek, Debayan Bhaumik, Paul J Bryce, C Shad Thaxton.
Mol Cancer Ther, 2017 Dec 29; 17(3). PMID: 29282300    Free PMC article.
Immune system and melanoma biology: a balance between immunosurveillance and immune escape.
Anna Passarelli, Francesco Mannavola, +2 authors, Francesco Silvestris.
Oncotarget, 2017 Dec 30; 8(62). PMID: 29285320    Free PMC article.
Predictors of response and resistance to checkpoint inhibitors in solid tumors.
Sanjana V Rao, Amy E Moran, Julie N Graff.
Ann Transl Med, 2017 Dec 30; 5(23). PMID: 29285501    Free PMC article.
Cancer immunotherapy-targeted glypican-3 or neoantigens.
Yasuhiro Shimizu, Toshihiro Suzuki, +4 authors, Tetsuya Nakatsura.
Cancer Sci, 2017 Dec 30; 109(3). PMID: 29285841    Free PMC article.
Implementation of "clinical sequencing" in cancer genome medicine in Japan.
Takashi Kohno.
Cancer Sci, 2017 Dec 30; 109(3). PMID: 29285848    Free PMC article.
Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens.
Kazuma Kiyotani, Hiu Ting Chan, Yusuke Nakamura.
Cancer Sci, 2017 Dec 31; 109(3). PMID: 29288513    Free PMC article.
Mutation load and an effector T-cell gene signature may distinguish immunologically distinct and clinically relevant lymphoma subsets.
Christopher R Bolen, Ronald McCord, +10 authors, Jeffrey M Venstrom.
Blood Adv, 2018 Jan 04; 1(22). PMID: 29296835    Free PMC article.
Off-the-shelf TCR for graft-versus-leukemia without GVHD.
Frederick L Locke, Claudio Anasetti.
Blood, 2018 Jan 06; 131(1). PMID: 29301771    Free PMC article.
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma.
Diana Miao, Claire A Margolis, +23 authors, Eliezer M Van Allen.
Science, 2018 Jan 06; 359(6377). PMID: 29301960    Free PMC article.
Highly Cited.
A novel immunization strategy using cytokine/chemokines induces new effective systemic immune responses, and frequent complete regressions of human metastatic melanoma.
Fred T Valentine, Frederick M Golomb, Matthew Harris, Daniel F Roses.
Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308310    Free PMC article.
Inhibitors of the PD-1 Pathway in Tumor Therapy.
Martin W LaFleur, Yuki Muroyama, Charles G Drake, Arlene H Sharpe.
J Immunol, 2018 Jan 10; 200(2). PMID: 29311378    Free PMC article.
Neoantigen Targeting-Dawn of a New Era in Cancer Immunotherapy?
Thomas C Wirth, Florian Kühnel.
Front Immunol, 2018 Jan 10; 8. PMID: 29312332    Free PMC article.
Highly Cited. Review.
The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy.
Terhi Karpanen, Johanna Olweus.
Front Immunol, 2018 Jan 13; 8. PMID: 29321773    Free PMC article.
Early and Locally Advanced Metaplastic Breast Cancer: Presentation and Survival by Receptor Status in Surveillance, Epidemiology, and End Results (SEER) 2010-2014.
Mary C Schroeder, Priya Rastogi, +2 authors, Alexandra Thomas.
Oncologist, 2018 Jan 14; 23(4). PMID: 29330212    Free PMC article.
Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.
Hira Rizvi, Francisco Sanchez-Vega, +29 authors, Matthew D Hellmann.
J Clin Oncol, 2018 Jan 18; 36(7). PMID: 29337640    Free PMC article.
Highly Cited.
Hypermutation and microsatellite instability in gastrointestinal cancers.
Kizuki Yuza, Masayuki Nagahashi, +2 authors, Toshifumi Wakai.
Oncotarget, 2018 Jan 18; 8(67). PMID: 29340115    Free PMC article.
Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation.
Adam D Scheid, Virginia P Van Keulen, +9 authors, Larry R Pease.
J Immunol, 2018 Jan 21; 200(5). PMID: 29352003    Free PMC article.
Immunogenomics: A Negative Prostate Cancer Outcome Associated with TcR-γ/δ Recombinations.
Yaping N Tu, Wei Lue Tong, John M Yavorski, George Blanck.
Cancer Microenviron, 2018 Jan 23; 11(1). PMID: 29357011    Free PMC article.
Unwrapping the genomic characteristics of urothelial bladder cancer and successes with immune checkpoint blockade therapy.
Wen Cheng, Dian Fu, Feng Xu, Zhengyu Zhang.
Oncogenesis, 2018 Jan 24; 7(1). PMID: 29358573    Free PMC article.
Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma.
Joshua R Veatch, Sylvia M Lee, +10 authors, Stanley R Riddell.
J Clin Invest, 2018 Jan 24; 128(4). PMID: 29360643    Free PMC article.
Highly Cited.
Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma.
E Ghorani, R Rosenthal, +5 authors, S A Quezada.
Ann Oncol, 2018 Jan 24; 29(1). PMID: 29361136    Free PMC article.
Highly Cited.
Colorectal Cancers: An Update on Their Molecular Pathology.
Kentaro Inamura.
Cancers (Basel), 2018 Jan 25; 10(1). PMID: 29361689    Free PMC article.
Highly Cited. Review.
Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations.
Zishuo I Hu, Jinru Shia, +14 authors, Eileen M O'Reilly.
Clin Cancer Res, 2018 Jan 26; 24(6). PMID: 29367431    Free PMC article.
Highly Cited.
Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials.
Sandra P D'Angelo, Michelle R Mahoney, +8 authors, Howard Streicher.
Lancet Oncol, 2018 Jan 27; 19(3). PMID: 29370992    Free PMC article.
Highly Cited.
Incorporating Radiation Oncology into Immunotherapy: proceedings from the ASTRO-SITC-NCI immunotherapy workshop.
Ariel E Marciscano, Joshua M Walker, +6 authors, Mansoor M Ahmed.
J Immunother Cancer, 2018 Jan 30; 6(1). PMID: 29375032    Free PMC article.
Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients.
Niki Karachaliou, Maria Gonzalez-Cao, +15 authors, Rafael Rosell.
Ther Adv Med Oncol, 2018 Feb 01; 10. PMID: 29383037    Free PMC article.
Highly Cited.
Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas.
Belen Hernandez, Hibret A Adissu, +3 authors, R Mark Simpson.
Int J Mol Sci, 2018 Feb 02; 19(2). PMID: 29385676    Free PMC article.
Activity of pembrolizumab in relapsed/refractory NK/T-cell lymphoma.
Xin Li, Yasong Cheng, +15 authors, Ken H Young.
J Hematol Oncol, 2018 Feb 02; 11(1). PMID: 29386072    Free PMC article.
Highly Cited.
Bringing the next Generation of Immuno-Oncology Biomarkers to the Clinic.
Alessandra Cesano, Sarah Warren.
Biomedicines, 2018 Feb 03; 6(1). PMID: 29393888    Free PMC article.
Highly Cited. Review.
Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy.
Aurélie Durgeau, Yasemin Virk, Stéphanie Corgnac, Fathia Mami-Chouaib.
Front Immunol, 2018 Feb 07; 9. PMID: 29403496    Free PMC article.
Highly Cited. Review.
Genetic status of KRAS influences Transforming Growth Factor-beta (TGF-β) signaling: An insight into Neuropilin-1 (NRP1) mediated tumorigenesis.
Sneha Vivekanandhan, Debabrata Mukhopadhyay.
Semin Cancer Biol, 2018 Feb 08; 54. PMID: 29409705    Free PMC article.
Emerging Biomarkers in Cutaneous Melanoma.
Anna Eisenstein, Estela Chen Gonzalez, +6 authors, Rhoda M Alani.
Mol Diagn Ther, 2018 Feb 08; 22(2). PMID: 29411301
A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer.
Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang.
Transl Oncol, 2018 Feb 08; 11(2). PMID: 29413765    Free PMC article.
Highly Cited.
Exome sequencing reveals aberrant signalling pathways as hallmark of treatment-naive anal squamous cell carcinoma.
Wulfran Cacheux, Virginie Dangles-Marie, +17 authors, Astrid Lièvre.
Oncotarget, 2018 Feb 09; 9(1). PMID: 29416628    Free PMC article.
Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer.
Philip H Abbosh, Elizabeth R Plimack.
Bladder Cancer, 2018 Feb 13; 4(1). PMID: 29430503    Free PMC article.
Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients.
Ari Vanderwalde, David Spetzler, +2 authors, John Marshall.
Cancer Med, 2018 Feb 13; 7(3). PMID: 29436178    Free PMC article.
Highly Cited.
Immune Checkpoint Blockade: The New Frontier in Cancer Treatment.
Jeffrey M Clarke, Daniel J George, Stacey Lisi, April K S Salama.
Target Oncol, 2018 Feb 15; 13(1). PMID: 29441437
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
Sanjeev Mariathasan, Shannon J Turley, +39 authors, Thomas Powles.
Nature, 2018 Feb 15; 554(7693). PMID: 29443960    Free PMC article.
Highly Cited.
Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection.
Scott Balsitis, Volodymyr Gali, +16 authors, Daniel J Tenney.
PLoS One, 2018 Feb 15; 13(2). PMID: 29444087    Free PMC article.
Temozolomide-associated hypermutation in gliomas.
Serah Choi, Yao Yu, +3 authors, Joseph F Costello.
Neuro Oncol, 2018 Feb 17; 20(10). PMID: 29452419    Free PMC article.
Highly Cited. Review.
Re-Emergence of Dendritic Cell Vaccines for Cancer Treatment.
Mansi Saxena, Nina Bhardwaj.
Trends Cancer, 2018 Feb 21; 4(2). PMID: 29458962    Free PMC article.
Highly Cited. Review.
Peripheral blood clinical laboratory variables associated with outcomes following combination nivolumab and ipilimumab immunotherapy in melanoma.
Samuel Rosner, Erica Kwong, +9 authors, Michael A Postow.
Cancer Med, 2018 Feb 23; 7(3). PMID: 29468834    Free PMC article.
Highly Cited.
Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.
Yared Hailemichael, Amber Woods, +17 authors, Willem W Overwijk.
J Clin Invest, 2018 Feb 27; 128(4). PMID: 29480817    Free PMC article.
Highly Cited.
Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma.
Young Kwang Chae, Jonathan F Anker, +3 authors, Jeffrey H Chuang.
Oncotarget, 2018 Mar 01; 9(8). PMID: 29487705    Free PMC article.
CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival.
P S Zeiner, J Zinke, +16 authors, P N Harter.
Acta Neuropathol Commun, 2018 Mar 02; 6(1). PMID: 29490700    Free PMC article.
Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma.
Daniel Xia, Ruben Casanova, +4 authors, Alex Soltermann.
Sci Rep, 2018 Mar 04; 8(1). PMID: 29500362    Free PMC article.
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis.
Constantinos Roufas, Dimitrios Chasiotis, +3 authors, Apostolos Zaravinos.
Front Oncol, 2018 Mar 09; 8. PMID: 29515971    Free PMC article.
New therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles.
Takahiro Nakagomi, Taichiro Goto, +8 authors, Masao Omata.
Oncotarget, 2018 Mar 15; 9(12). PMID: 29535832    Free PMC article.
Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer.
Sara Bobisse, Raphael Genolet, +21 authors, Alexandre Harari.
Nat Commun, 2018 Mar 17; 9(1). PMID: 29545564    Free PMC article.
Highly Cited.
Current status and perspectives in immunotherapy for metastatic melanoma.
Riccardo Marconcini, Francesco Spagnolo, +13 authors, Italian Melanoma Intergroup (IMI).
Oncotarget, 2018 Mar 20; 9(15). PMID: 29552325    Free PMC article.
Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.
Gao Zhang, Lawrence W Wu, +41 authors, Jerry W Shay.
Clin Cancer Res, 2018 Mar 23; 24(19). PMID: 29563139    Free PMC article.
Current status of immunotherapy and immune biomarkers in gastro-esophageal cancers.
Nischala Ammannagari, Ajlan Atasoy.
J Gastrointest Oncol, 2018 Mar 23; 9(1). PMID: 29564185    Free PMC article.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada.
Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375    Free PMC article.
Highly Cited.
Erlotinib in the treatment of recurrent or metastatic cutaneous squamous cell carcinoma: A single-arm phase 2 clinical trial.
Kathryn A Gold, Merrill S Kies, +3 authors, Bonnie S Glisson.
Cancer, 2018 Mar 27; 124(10). PMID: 29579331    Free PMC article.
Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments.
Johan Karlsson, Hannah J Vaughan, Jordan J Green.
Annu Rev Chem Biomol Eng, 2018 Mar 27; 9. PMID: 29579402    Free PMC article.
Perspectives on the clinical development of immunotherapy in prostate cancer.
Lisa M Cordes, James L Gulley, Ravi A Madan.
Asian J Androl, 2018 Mar 28; 20(3). PMID: 29582792    Free PMC article.
Distinctive features of immunostaining and mutational load in primary pulmonary enteric adenocarcinoma: implications for differential diagnosis and immunotherapy.
Ming Chen, Pu Liu, +5 authors, Peng Shen.
J Transl Med, 2018 Mar 29; 16(1). PMID: 29587865    Free PMC article.
Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes.
Kalpana Mujoo, Clayton R Hunt, +5 authors, Tej K Pandita.
Mol Cancer Res, 2018 Mar 30; 16(8). PMID: 29592896    Free PMC article.
Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide.
Yohei Takeda, Masahiro Azuma, +3 authors, Tsukasa Seya.
Front Immunol, 2018 Mar 30; 9. PMID: 29593736    Free PMC article.
Immune checkpoint inhibitors in small cell lung cancer.
Suchita Pakkala, Taofeek K Owonikoko.
J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593891    Free PMC article.
Tumor immunity landscape in non-small cell lung cancer.
Xiaoqing Yu, Xuefeng Wang.
PeerJ, 2018 Mar 30; 6. PMID: 29593943    Free PMC article.
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.
Daniel J McGrail, Lorenzo Federico, +6 authors, Nidhi Sahni.
Nat Commun, 2018 Apr 05; 9(1). PMID: 29615613    Free PMC article.
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.
Randi B Gombos, Ana Gonzalez, +24 authors, Nicholas S Wilson.
PLoS One, 2018 Apr 05; 13(4). PMID: 29617360    Free PMC article.
Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination.
Tyler W Hulett, Shawn M Jensen, +6 authors, Bernard A Fox.
J Immunother Cancer, 2018 Apr 06; 6(1). PMID: 29618380    Free PMC article.
Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma.
Hyun-Sung Lee, Hee-Jin Jang, +11 authors, Bryan M Burt.
JCI Insight, 2018 Apr 06; 3(7). PMID: 29618661    Free PMC article.
Combination Immunotherapy: Taking Cancer Vaccines to the Next Level.
Jeremy M Grenier, Stephen T Yeung, Kamal M Khanna.
Front Immunol, 2018 Apr 07; 9. PMID: 29623082    Free PMC article.
Immunotherapy of melanoma.
Iwona Lugowska, Pawel Teterycz, Piotr Rutkowski.
Contemp Oncol (Pozn), 2018 Apr 10; 22(1A). PMID: 29628796    Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations.
Judith A Seidel, Atsushi Otsuka, Kenji Kabashima.
Front Oncol, 2018 Apr 13; 8. PMID: 29644214    Free PMC article.
Highly Cited. Review.
Population-level distribution and putative immunogenicity of cancer neoepitopes.
Mary A Wood, Mayur Paralkar, +6 authors, Reid F Thompson.
BMC Cancer, 2018 Apr 15; 18(1). PMID: 29653567    Free PMC article.
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.
Sachet A Shukla, Pavan Bachireddy, +29 authors, Catherine J Wu.
Cell, 2018 Apr 17; 173(3). PMID: 29656892    Free PMC article.
Highly Cited.
Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.
Matthew D Hellmann, Tavi Nathanson, +29 authors, Jedd D Wolchok.
Cancer Cell, 2018 Apr 17; 33(5). PMID: 29657128    Free PMC article.
Highly Cited.
Melanoma: What do all the mutations mean?
Elizabeth J Davis, Douglas B Johnson, Jeffrey A Sosman, Sunandana Chandra.
Cancer, 2018 Apr 18; 124(17). PMID: 29663336    Free PMC article.
The perfect personalized cancer therapy: cancer vaccines against neoantigens.
Luigi Aurisicchio, Matteo Pallocca, Gennaro Ciliberto, Fabio Palombo.
J Exp Clin Cancer Res, 2018 Apr 22; 37(1). PMID: 29678194    Free PMC article.
APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.
Shixiang Wang, Mingming Jia, Zaoke He, Xue-Song Liu.
Oncogene, 2018 Apr 27; 37(29). PMID: 29695832    Free PMC article.
Highly Cited.
BRCA1/2 and TP53 mutation status associates with PD-1 and PD-L1 expression in ovarian cancer.
Verena Wieser, Inge Gaugg, +7 authors, Christian Marth.
Oncotarget, 2018 May 01; 9(25). PMID: 29707124    Free PMC article.
Increased immune infiltration and chemokine receptor expression in head and neck epithelial tumors after neoadjuvant immunotherapy with the IRX-2 regimen.
Neil L Berinstein, Michael McNamara, +2 authors, Gregory T Wolf.
Oncoimmunology, 2018 May 04; 7(5). PMID: 29721379    Free PMC article.
Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab.
Anders H Kverneland, Christian Enevold, +3 authors, Claus H Nielsen.
Oncoimmunology, 2018 May 04; 7(5). PMID: 29721387    Free PMC article.
Review of diagnostic, prognostic, and predictive biomarkers in melanoma.
Jacob S Ankeny, Brian Labadie, +3 authors, Jonathan S Zager.
Clin Exp Metastasis, 2018 May 04; 35(5-6). PMID: 29722000
Mutation load estimation model as a predictor of the response to cancer immunotherapy.
Guan-Yi Lyu, Yu-Hsuan Yeh, Yi-Chen Yeh, Yu-Chao Wang.
NPJ Genom Med, 2018 May 08; 3. PMID: 29736260    Free PMC article.
Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden.
Carl Morrison, Sarabjot Pabla, +33 authors, Marc S Ernstoff.
J Immunother Cancer, 2018 May 11; 6(1). PMID: 29743104    Free PMC article.
Approaches to Improve Chemically Defined Synthetic Peptide Vaccines.
Brett J Hos, Elena Tondini, Sander I van Kasteren, Ferry Ossendorp.
Front Immunol, 2018 May 15; 9. PMID: 29755468    Free PMC article.
Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma.
Jeffrey P North, Justin Golovato, +12 authors, Raymond J Cho.
Nat Commun, 2018 May 16; 9(1). PMID: 29760388    Free PMC article.
A Convergence-Based Framework for Cancer Drug Resistance.
David J Konieczkowski, Cory M Johannessen, Levi A Garraway.
Cancer Cell, 2018 May 16; 33(5). PMID: 29763622    Free PMC article.
Highly Cited. Review.
Targeted therapy or immunotherapy? Optimal treatment in hepatocellular carcinoma.
Merly Contratto, Jennifer Wu.
World J Gastrointest Oncol, 2018 May 18; 10(5). PMID: 29770170    Free PMC article.
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.
Ferdinandos Skoulidis, Michael E Goldberg, +66 authors, John V Heymach.
Cancer Discov, 2018 May 19; 8(7). PMID: 29773717    Free PMC article.
Highly Cited.
Concepts Collide: Genomic, Immune, and Microbial Influences on the Tumor Microenvironment and Response to Cancer Therapy.
Miles C Andrews, Alexandre Reuben, Vancheswaran Gopalakrishnan, Jennifer A Wargo.
Front Immunol, 2018 May 22; 9. PMID: 29780391    Free PMC article.
Vaccine immunotherapy with ARNAX induces tumor-specific memory T cells and durable anti-tumor immunity in mouse models.
Yohei Takeda, Sumito Yoshida, +4 authors, Misako Matsumoto.
Cancer Sci, 2018 May 24; 109(7). PMID: 29791768    Free PMC article.
TP53 Mutation as Potential Negative Predictor for Response of Anti-CTLA-4 Therapy in Metastatic Melanoma.
Wenjing Xiao, Nan Du, +10 authors, Jing Chen.
EBioMedicine, 2018 May 26; 32. PMID: 29793878    Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer.
Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang.
J Mol Biol, 2018 May 26; 430(14). PMID: 29800567    Free PMC article.
An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0.
Ryan J Sullivan, Michael B Atkins, +25 authors, Howard L Kaufman.
J Immunother Cancer, 2018 Jun 01; 6(1). PMID: 29848375    Free PMC article.
Advanced small cell lung cancer (SCLC): new challenges and new expectations.
Nikolaos Tsoukalas, Eleni Aravantinou-Fatorou, +5 authors, George Kyrgias.
Ann Transl Med, 2018 Jun 05; 6(8). PMID: 29862234    Free PMC article.
Precision medicine based on surgical oncology in the era of genome-scale analysis and genome editing technology.
Shinji Tanaka.
Ann Gastroenterol Surg, 2018 Jun 05; 2(2). PMID: 29863171    Free PMC article.
Multiplex bead-based measurement of humoral immune responses against tumor-associated antigens in stage II melanoma patients of the EORTC18961 trial.
Judith Michels, Natalia Becker, +11 authors, Inka Zörnig.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872552    Free PMC article.
Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial.
Poulam M Patel, Christian H Ottensmeier, +15 authors, Lindy G Durrant.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872563    Free PMC article.
Cancer immunotherapy: broadening the scope of targetable tumours.
Jitske van den Bulk, Els Me Verdegaal, Noel Fcc de Miranda.
Open Biol, 2018 Jun 08; 8(6). PMID: 29875199    Free PMC article.
Immune checkpoint inhibitors in urothelial cancer: recent updates and future outlook.
Dharmesh Gopalakrishnan, Vadim S Koshkin, +2 authors, Petros Grivas.
Ther Clin Risk Manag, 2018 Jun 13; 14. PMID: 29892196    Free PMC article.
Molecular profiles and tumor mutational burden analysis in Chinese patients with gynecologic cancers.
Min Wang, Wensheng Fan, +11 authors, Yuanguang Meng.
Sci Rep, 2018 Jun 14; 8(1). PMID: 29895933    Free PMC article.
Melanoma Immunotherapy: Next-Generation Biomarkers.
Sabrina A Hogan, Mitchell P Levesque, Phil F Cheng.
Front Oncol, 2018 Jun 14; 8. PMID: 29896449    Free PMC article.
Pathogenesis of Skin Carcinomas and a Stem Cell as Focal Origin.
Frank R de Gruijl, Cornelis P Tensen.
Front Med (Lausanne), 2018 Jun 14; 5. PMID: 29896477    Free PMC article.
Breast Cancer Immunotherapy: An Update.
Issam Makhoul, Mohammad Atiq, Ahmed Alwbari, Thomas Kieber-Emmons.
Breast Cancer (Auckl), 2018 Jun 15; 12. PMID: 29899661    Free PMC article.
The possibility of cancer immune editing in gliomas. A critical review.
Víctor A Arrieta, Bernardo Cacho-Díaz, +3 authors, Adam M Sonabend.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900059    Free PMC article.
Understanding Intratumor Heterogeneity and Evolution in NSCLC and Potential New Therapeutic Approach.
Taichiro Goto, Yosuke Hirotsu, +2 authors, Masao Omata.
Cancers (Basel), 2018 Jun 23; 10(7). PMID: 29932159    Free PMC article.
Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma.
Leonardo Vinícius Monteiro de Assis, Gabriela Sarti Kinker, +3 authors, Ana Maria de Lauro Castrucci.
Front Oncol, 2018 Jun 28; 8. PMID: 29946530    Free PMC article.
Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment.
Elizabeth A Comen, Robert L Bowman, Maria Kleppe.
Front Cell Dev Biol, 2018 Jun 28; 6. PMID: 29946544    Free PMC article.
Pediatric Cancer Immunotherapy: Opportunities and Challenges.
Mary Frances Wedekind, Nicholas L Denton, Chun-Yu Chen, Timothy P Cripe.
Paediatr Drugs, 2018 Jun 28; 20(5). PMID: 29948928    Free PMC article.
Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors.
Anshuman Panda, Anil Betigeri, +14 authors, Shridar Ganesan.
JCO Precis Oncol, 2017 Jan 01; 2017. PMID: 29951597    Free PMC article.
Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers.
Muhammad Umair Mushtaq, Athanasios Papadas, +4 authors, Fotis Asimakopoulos.
J Immunother Cancer, 2018 Jul 05; 6(1). PMID: 29970158    Free PMC article.
Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy.
Nobuo Kondoh, Masako Mizuno-Kamiya, +5 authors, Iwai Tohnai.
Open Dent J, 2018 Jul 11; 12. PMID: 29988281    Free PMC article.
Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond.
Emily M Lin, Jun Gong, Samuel J Klempner, Joseph Chao.
World J Gastroenterol, 2018 Jul 12; 24(25). PMID: 29991874    Free PMC article.
Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy).
Paolo A Ascierto, James Brugarolas, +16 authors, Igor Puzanov.
J Immunother Cancer, 2018 Jul 13; 6(1). PMID: 29996914    Free PMC article.
Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy.
Chongkai Wang, Jun Gong, +2 authors, Marwan Fakih.
J Gastrointest Oncol, 2018 Jul 13; 9(3). PMID: 29998005    Free PMC article.
Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies.
Vanessa M Tubb, Deborah S Schrikkema, +7 authors, Gavin M Bendle.
J Immunother Cancer, 2018 Jul 14; 6(1). PMID: 30001747    Free PMC article.
Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges.
Lorenzo Pilla, Cristina Maccalli.
Biomedicines, 2018 Jul 14; 6(3). PMID: 30004433    Free PMC article.
Novel frontiers in detecting cancer metastasis.
Stanley P Leong, Carmen Ballesteros-Merino, +4 authors, Mojca Skoberne.
Clin Exp Metastasis, 2018 Jul 20; 35(5-6). PMID: 30022365
Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies.
Anna Minchom, Caterina Aversa, Juanita Lopez.
Ther Adv Med Oncol, 2018 Jul 20; 10. PMID: 30023007    Free PMC article.
The Tumor Mutational Burden of Chinese Advanced Cancer Patients Estimated by a 381-cancer-gene Panel.
Wu Zhuang, Junxun Ma, +14 authors, Zhijie Wang.
J Cancer, 2018 Jul 22; 9(13). PMID: 30026825    Free PMC article.
The evolving immunotherapeutic landscape in advanced oesophagogastric cancer.
Michael Flynn, Kate Young, David Cunningham, Naureen Starling.
Ther Adv Med Oncol, 2018 Jul 24; 10. PMID: 30034550    Free PMC article.
Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.
Enric Domingo, Carme Camps, +26 authors, Ian Tomlinson.
Lancet Gastroenterol Hepatol, 2018 Jul 26; 3(9). PMID: 30042065    Free PMC article.
Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration.
Ayman Oweida, Mohammad K Hararah, +14 authors, Sana D Karam.
Clin Cancer Res, 2018 Jul 26; 24(21). PMID: 30042205    Free PMC article.
Highly Cited.
Immunogenomics Analysis Reveals that TP53 Mutations Inhibit Tumor Immunity in Gastric Cancer.
Zehang Jiang, Zhixian Liu, +2 authors, Xiaosheng Wang.
Transl Oncol, 2018 Jul 31; 11(5). PMID: 30059832    Free PMC article.
Role of Immunotherapy for Oncogene-Driven Non-Small Cell Lung Cancer.
Yosuke Miura, Noriaki Sunaga.
Cancers (Basel), 2018 Aug 01; 10(8). PMID: 30060457    Free PMC article.
Emerging strategies for combination checkpoint modulators in cancer immunotherapy.
Aleksandra Popovic, Elizabeth M Jaffee, Neeha Zaidi.
J Clin Invest, 2018 Aug 02; 128(8). PMID: 30067248    Free PMC article.
Highly Cited. Review.
Emerging biomarkers and targeted therapies in urothelial carcinoma.
Prateek Mendiratta, Petros Grivas.
Ann Transl Med, 2018 Aug 03; 6(12). PMID: 30069452    Free PMC article.
Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer.
Jingying Nong, Yuhua Gong, +24 authors, Jinghui Wang.
Nat Commun, 2018 Aug 08; 9(1). PMID: 30082701    Free PMC article.
Checkpoint blockade-based immunotherapy in the context of tumor microenvironment: Opportunities and challenges.
Jingjing Duan, Yu Wang, Shunchang Jiao.
Cancer Med, 2018 Aug 09; 7(9). PMID: 30088347    Free PMC article.
The Cancer Omics Atlas: an integrative resource for cancer omics annotations.
Qingrong Sun, Mengyuan Li, Xiaosheng Wang.
BMC Med Genomics, 2018 Aug 10; 11(1). PMID: 30089500    Free PMC article.
Predicting Antigen Presentation-What Could We Learn From a Million Peptides?
David Gfeller, Michal Bassani-Sternberg.
Front Immunol, 2018 Aug 10; 9. PMID: 30090105    Free PMC article.
Highly Cited. Review.
Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy.
Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes Vom Berg.
Front Oncol, 2018 Aug 10; 8. PMID: 30090763    Free PMC article.
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.
S N Gettinger, J Choi, +19 authors, K A Schalper.
Nat Commun, 2018 Aug 12; 9(1). PMID: 30097571    Free PMC article.
Metastatic Melanoma: Recent Therapeutic Progress and Future Perspectives.
Nausicaa Malissen, Jean-Jacques Grob.
Drugs, 2018 Aug 12; 78(12). PMID: 30097888
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
Joo Sang Lee, Lital Adler, +31 authors, Ayelet Erez.
Cell, 2018 Aug 14; 174(6). PMID: 30100185    Free PMC article.
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo.
Sarwish Rafiq, Oladapo O Yeku, +14 authors, Renier J Brentjens.
Nat Biotechnol, 2018 Aug 14; 36(9). PMID: 30102295    Free PMC article.
Highly Cited.
Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines.
Feng Qiu, Kyle W Becker, +6 authors, John T Wilson.
Biomaterials, 2018 Aug 15; 182. PMID: 30107272    Free PMC article.
Intron retention is a source of neoepitopes in cancer.
Alicia C Smart, Claire A Margolis, +6 authors, Eliezer M Van Allen.
Nat Biotechnol, 2018 Aug 17; 36(11). PMID: 30114007    Free PMC article.
Highly Cited.
Abscopal effect of radiotherapy combined with immune checkpoint inhibitors.
Yang Liu, Yinping Dong, +3 authors, Jinming Yu.
J Hematol Oncol, 2018 Aug 18; 11(1). PMID: 30115069    Free PMC article.
Highly Cited. Review.
Identification of non-mutated neoantigens presented by TAP-deficient tumors.
Koen A Marijt, Laura Blijleven, +7 authors, Thorbald van Hall.
J Exp Med, 2018 Aug 18; 215(9). PMID: 30115740    Free PMC article.
Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer.
Nataly Manjarrez-Orduño, Laurence C Menard, +15 authors, Steven G Nadler.
Front Immunol, 2018 Aug 21; 9. PMID: 30123214    Free PMC article.
Predictive biomarkers for immune checkpoint inhibitor therapy: we need to keep searching.
Mary M Huerter, Apar Kishor Ganti.
J Thorac Dis, 2018 Aug 21; 10(Suppl 18). PMID: 30123559    Free PMC article.
Immunological-based approaches for cancer therapy.
Luciana Barros, Marco Antonio Pretti, +3 authors, Martin Hernán Bonamino.
Clinics (Sao Paulo), 2018 Aug 23; 73(suppl 1). PMID: 30133560    Free PMC article.
Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma.
Anshuman Panda, Aguirre A de Cubas, +10 authors, W Kimryn Rathmell.
JCI Insight, 2018 Aug 24; 3(16). PMID: 30135306    Free PMC article.
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance.
Young-Jun Park, Da-Sol Kuen, Yeonseok Chung.
Exp Mol Med, 2018 Aug 24; 50(8). PMID: 30135516    Free PMC article.
Highly Cited. Review.
Clinical and genetic associations with prostacyclin response in pulmonary arterial hypertension.
Stephen J Halliday, Meng Xu, +10 authors, Anna R Hemnes.
Pulm Circ, 2018 Aug 25; 8(4). PMID: 30142026    Free PMC article.
Precision medicine in cholangiocarcinoma.
Antonio Pellino, Fotios Loupakis, +6 authors, Luca Fabris.
Transl Gastroenterol Hepatol, 2018 Aug 28; 3. PMID: 30148225    Free PMC article.
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors.
Diana Miao, Claire A Margolis, +28 authors, Eliezer M Van Allen.
Nat Genet, 2018 Aug 29; 50(9). PMID: 30150660    Free PMC article.
Highly Cited.
Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition.
David A Fabrizio, Thomas J George, +13 authors, Samuel J Klempner.
J Gastrointest Oncol, 2018 Aug 29; 9(4). PMID: 30151257    Free PMC article.
Highly Cited.
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options.
Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül.
Front Immunol, 2018 Aug 31; 9. PMID: 30158932    Free PMC article.
Strategies for Predicting Response to Checkpoint Inhibitors.
Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub.
Curr Hematol Malig Rep, 2018 Aug 31; 13(5). PMID: 30159703    Free PMC article.
Identifying neoantigens for use in immunotherapy.
Sharon Hutchison, Antonia L Pritchard.
Mamm Genome, 2018 Sep 01; 29(11-12). PMID: 30167844    Free PMC article.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity.
Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar.
J Autoimmun, 2018 Sep 04; 95. PMID: 30174217    Free PMC article.
T Cell-Inflamed versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection.
Jonathan A Trujillo, Randy F Sweis, Riyue Bao, Jason J Luke.
Cancer Immunol Res, 2018 Sep 06; 6(9). PMID: 30181337    Free PMC article.
Highly Cited.
A Comprehensive Survey of Immune Cytolytic Activity-Associated Gene Co-Expression Networks across 17 Tumor and Normal Tissue Types.
Tian Tian, Ji Wan, +5 authors, Zhi Wei.
Cancers (Basel), 2018 Sep 06; 10(9). PMID: 30181502    Free PMC article.
Activation of viral defense signaling in cancer.
Maria Gonzalez-Cao, Niki Karachaliou, +3 authors, Rafael Rosell.
Ther Adv Med Oncol, 2018 Sep 06; 10. PMID: 30181782    Free PMC article.
Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models.
Roberto R Rosato, Daniel Dávila-González, +6 authors, Jenny C Chang.
Breast Cancer Res, 2018 Sep 07; 20(1). PMID: 30185216    Free PMC article.
Immune Checkpoint Inhibitors: Toward New Paradigms in Renal Cell Carcinoma.
Ronan Flippot, Bernard Escudier, Laurence Albiges.
Drugs, 2018 Sep 07; 78(14). PMID: 30187355
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis.
William P D Hendricks, Victoria Zismann, +24 authors, Jeffrey M Trent.
PLoS Genet, 2018 Sep 07; 14(9). PMID: 30188888    Free PMC article.
From personalized to patient-specific treatment of metastatic melanoma.
Robert O Dillman.
Melanoma Manag, 2015 Aug 01; 2(3). PMID: 30190848    Free PMC article.
Immune checkpoint inhibitors in melanoma.
Adam J Cooper, Matteo S Carlino, Richard F Kefford.
Melanoma Manag, 2015 Aug 01; 2(3). PMID: 30190854    Free PMC article.
Targeting immune checkpoints in melanoma: an update.
Rodrigo R Munhoz, Alejandro Falcón González, Vanessa A Reed, Michael A Postow.
Melanoma Manag, 2015 Nov 01; 2(4). PMID: 30190862    Free PMC article.
Immunotherapy for uveal melanoma.
Dae Won Kim, Jaime Anderson, Sapna P Patel.
Melanoma Manag, 2016 Jun 01; 3(2). PMID: 30190881    Free PMC article.
Neoadjuvant treatment for melanoma: current challenges and future perspectives.
Yana G Najjar, John M Kirkwood.
Melanoma Manag, 2016 Jun 01; 3(2). PMID: 30190883    Free PMC article.
The cutting edge of metastatic melanoma therapy.
Antonia Digklia, Olivier Michielin.
Melanoma Manag, 2016 Sep 01; 3(3). PMID: 30190891    Free PMC article.
Immuno-Oncology: Emerging Targets and Combination Therapies.
Henry T Marshall, Mustafa B A Djamgoz.
Front Oncol, 2018 Sep 08; 8. PMID: 30191140    Free PMC article.
Highly Cited. Review.
A cancer vaccine with dendritic cells differentiated with GM-CSF and IFNα and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model.
Ananda Mookerjee, Michele Graciotti, Lana E Kandalaft, Lana Kandalaft.
Bioimpacts, 2018 Sep 14; 8(3). PMID: 30211081    Free PMC article.
Immune Checkpoint Inhibition in Head and Neck Cancer.
Martin David Forster, Michael-John Devlin.
Front Oncol, 2018 Sep 14; 8. PMID: 30211111    Free PMC article.
Clinical Relevance of Genomic Changes in Recurrent Pediatric Solid Tumors.
Boram Lee, Ji Won Lee, +6 authors, Woong-Yang Park.
Transl Oncol, 2018 Sep 15; 11(6). PMID: 30216764    Free PMC article.
Clinical implication of tumor mutational burden in patients with HER2-positive refractory metastatic breast cancer.
Song Ee Park, Kyunghee Park, +9 authors, Yeon Hee Park.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221068    Free PMC article.
TSNAdb: A Database for Tumor-specific Neoantigens from Immunogenomics Data Analysis.
Jingcheng Wu, Wenyi Zhao, +4 authors, Shuqing Chen.
Genomics Proteomics Bioinformatics, 2018 Sep 18; 16(4). PMID: 30223042    Free PMC article.
Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer.
Fabian Coscia, Ernst Lengyel, +12 authors, Marion Curtis.
Cell, 2018 Sep 23; 175(1). PMID: 30241606    Free PMC article.
Genomic Characterization of Six Virus-Associated Cancers Identifies Changes in the Tumor Immune Microenvironment and Altered Genetic Programs.
Frederick S Varn, Evelien Schaafsma, Yue Wang, Chao Cheng.
Cancer Res, 2018 Sep 27; 78(22). PMID: 30254145    Free PMC article.
Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment.
Yien Ning Sophia Wong, Kroopa Joshi, +22 authors, Sergio A Quezada.
J Exp Med, 2018 Sep 28; 215(11). PMID: 30257862    Free PMC article.
Immune Marker Profiling and Programmed Death Ligand 1 Expression Across NSCLC Mutations.
Maria I Toki, Nikita Mani, +7 authors, David L Rimm.
J Thorac Oncol, 2018 Sep 30; 13(12). PMID: 30267840    Free PMC article.
DNA repair defects and implications for immunotherapy.
Katherine M Bever, Dung T Le.
J Clin Invest, 2018 Oct 03; 128(10). PMID: 30272580    Free PMC article.
Roles of the immune system in cancer: from tumor initiation to metastatic progression.
Hugo Gonzalez, Catharina Hagerling, Zena Werb.
Genes Dev, 2018 Oct 03; 32(19-20). PMID: 30275043    Free PMC article.
Highly Cited. Review.
PD1/PDL1 inhibitors for the treatment of advanced urothelial bladder cancer.
David D Stenehjem, Dao Tran, Michael A Nkrumah, Shilpa Gupta.
Onco Targets Ther, 2018 Oct 03; 11. PMID: 30275703    Free PMC article.
Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option.
Maartje W Rohaan, Joost H van den Berg, Pia Kvistborg, John B A G Haanen.
J Immunother Cancer, 2018 Oct 05; 6(1). PMID: 30285902    Free PMC article.
Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences.
Xinyu Yan, Shouyue Zhang, +3 authors, Heng Xu.
Front Pharmacol, 2018 Oct 09; 9. PMID: 30294272    Free PMC article.
The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis.
Caspar Mewes, Benedikt Büttner, +8 authors, Ashham Mansur.
Sci Rep, 2018 Oct 13; 8(1). PMID: 30310101    Free PMC article.
Patterns, predictors and subsequent outcomes of disease progression in metastatic renal cell carcinoma patients treated with nivolumab.
Haris Zahoor, Pedro C Barata, +8 authors, Brian I Rini.
J Immunother Cancer, 2018 Oct 20; 6(1). PMID: 30333065    Free PMC article.
Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer.
Heather L Kinkead, Alexander Hopkins, +12 authors, Neeha Zaidi.
JCI Insight, 2018 Oct 20; 3(20). PMID: 30333318    Free PMC article.
Therapeutic Sequencing in Metastatic Renal Cell Carcinoma.
Manuel Caitano Maia, Nazli Dizman, Meghan Salgia, Sumanta Kumar Pal.
Kidney Cancer, 2017 Jul 26; 1(1). PMID: 30334001    Free PMC article.
Unique true predicted neoantigens (TPNAs) correlates with anti-tumor immune control in HCC patients.
Annacarmen Petrizzo, Maria Tagliamonte, +9 authors, Luigi Buonaguro.
J Transl Med, 2018 Oct 21; 16(1). PMID: 30340600    Free PMC article.
Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer.
Chun-Chin Chen, Weiran Feng, +2 authors, Maria Jasin.
Annu Rev Cancer Biol, 2018 Oct 23; 2. PMID: 30345412    Free PMC article.
Highly Cited.
Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules.
Michael T Bethune, Xiao-Hua Li, +15 authors, David Baltimore.
Proc Natl Acad Sci U S A, 2018 Oct 24; 115(45). PMID: 30348802    Free PMC article.
Defective transcription elongation in a subset of cancers confers immunotherapy resistance.
Vishnu Modur, Navneet Singh, +14 authors, Kakajan Komurov.
Nat Commun, 2018 Oct 26; 9(1). PMID: 30353012    Free PMC article.
Exploring optimal sequencing of radiation and immunotherapy combinations.
Andrew J Gunderson, Kristina H Young.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370348    Free PMC article.
The DNA damage response in immunotherapy and radiation.
Robert M Samstein, Nadeem Riaz.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370352    Free PMC article.
SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics.
Franziska Singer, Anja Irmisch, +11 authors, Daniel J Stekhoven.
BMC Med Inform Decis Mak, 2018 Oct 31; 18(1). PMID: 30373609    Free PMC article.
Killer immunoglobulin-like receptor genotype did not correlate with response to anti-PD-1 antibody treatment in a Japanese cohort.
Yoshihiro Ishida, Chisa Nakashima, +8 authors, Kenji Kabashima.
Sci Rep, 2018 Oct 31; 8(1). PMID: 30374122    Free PMC article.
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer.
Alexandra Thomas, Eric D Routh, +17 authors, Lance D Miller.
Oncoimmunology, 2018 Nov 06; 7(10). PMID: 30386679    Free PMC article.
Highly Cited.
Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments.
Jong W Yu, Sabyasachi Bhattacharya, +24 authors, Roopa Srinivasan.
PLoS One, 2018 Nov 06; 13(11). PMID: 30388137    Free PMC article.
An assessment of prognostic immunity markers in breast cancer.
Benlong Yang, Jeff Chou, +13 authors, Zhiyuan Hu.
NPJ Breast Cancer, 2018 Nov 06; 4. PMID: 30393759    Free PMC article.
Radiotherapy induces responses of lung cancer to CTLA-4 blockade.
Silvia C Formenti, Nils-Petter Rudqvist, +15 authors, Sandra Demaria.
Nat Med, 2018 Nov 07; 24(12). PMID: 30397353    Free PMC article.
Highly Cited.
Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance.
Xingxiang Pu, Lin Wu, +2 authors, Bingliang Fang.
BMC Cancer, 2018 Nov 10; 18(1). PMID: 30409126    Free PMC article.
TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure.
Ankur Chakravarthy, Lubaba Khan, +2 authors, Daniel D De Carvalho.
Nat Commun, 2018 Nov 10; 9(1). PMID: 30410077    Free PMC article.
Highly Cited.
Promising clinical application of ctDNA in evaluating immunotherapy efficacy.
Li Li, Jun Zhang, Xiaoyue Jiang, Qin Li.
Am J Cancer Res, 2018 Nov 13; 8(10). PMID: 30416847    Free PMC article.
Mismatch repair-based stratification for immune checkpoint blockade therapy.
Lihong Zhang, Yang Peng, Guang Peng.
Am J Cancer Res, 2018 Nov 13; 8(10). PMID: 30416850    Free PMC article.
The role of autophagy in the treatment of BRAF mutant colorectal carcinomas differs based on microsatellite instability status.
Evangelos Koustas, Athanasios G Papavassiliou, Michalis V Karamouzis.
PLoS One, 2018 Nov 15; 13(11). PMID: 30427914    Free PMC article.
Genes at the Crossroad of Primary Immunodeficiencies and Cancer.
Charlotte Derpoorter, Victoria Bordon, +2 authors, Tim Lammens.
Front Immunol, 2018 Nov 18; 9. PMID: 30443258    Free PMC article.
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.
Hanghang Zhang, Somnath Pandey, +30 authors, Jean-Pierre J Issa.
Cell, 2018 Nov 21; 175(5). PMID: 30454645    Free PMC article.
Highly Cited.
The role of neoantigen in immune checkpoint blockade therapy.
Ming Yi, Shuang Qin, +3 authors, Kongming Wu.
Exp Hematol Oncol, 2018 Nov 27; 7. PMID: 30473928    Free PMC article.
Highly Cited. Review.
Using Frameshift Peptide Arrays for Cancer Neo-Antigens Screening.
Jian Zhang, Luhui Shen, Stephen Albert Johnston.
Sci Rep, 2018 Nov 28; 8(1). PMID: 30478295    Free PMC article.
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
Jianqin Lu, Xiangsheng Liu, +6 authors, Andre E Nel.
ACS Nano, 2018 Nov 30; 12(11). PMID: 30481959    Free PMC article.
Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine.
Jake R Conway, Eric Kofman, +2 authors, Eliezer Van Allen.
Genome Med, 2018 Dec 01; 10(1). PMID: 30497521    Free PMC article.
Transformation of Old Concepts for a New Era of Cancer Immunotherapy: Cytokine Therapy and Cancer Vaccines as Combination Partners of PD1/PD-L1 Inhibitors.
Romualdo Barroso-Sousa, Patrick A Ott.
Curr Oncol Rep, 2018 Dec 01; 21(1). PMID: 30498900
Rejection of immunogenic tumor clones is limited by clonal fraction.
Ron S Gejman, Aaron Y Chang, +4 authors, David A Scheinberg.
Elife, 2018 Dec 01; 7. PMID: 30499773    Free PMC article.
Novel immunotherapy approaches to follicular lymphoma.
Christopher R Flowers, John P Leonard, Loretta J Nastoupil.
Hematology Am Soc Hematol Educ Program, 2018 Dec 07; 2018(1). PMID: 30504310    Free PMC article.
A scalable solution for tumor mutational burden from formalin-fixed, paraffin-embedded samples using the Oncomine Tumor Mutation Load Assay.
Ruchi Chaudhary, Luca Quagliata, +7 authors, Fiona Hyland.
Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505706    Free PMC article.
Methods of measurement for tumor mutational burden in tumor tissue.
Bárbara Meléndez, Claude Van Campenhout, +3 authors, Nicky D'Haene.
Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505710    Free PMC article.
Highly Cited. Review.
Measuring tumor mutation burden in non-small cell lung cancer: tissue versus liquid biopsy.
Francesca Fenizia, Raffaella Pasquale, +3 authors, Nicola Normanno.
Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505711    Free PMC article.
Approach to evaluating tumor mutational burden in routine clinical practice.
John Truesdell, Vincent A Miller, David Fabrizio.
Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505712    Free PMC article.
Implementing tumor mutational burden (TMB) analysis in routine diagnostics-a primer for molecular pathologists and clinicians.
Michael Allgäuer, Jan Budczies, +13 authors, Albrecht Stenzinger.
Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505715    Free PMC article.
Highly Cited. Review.
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
Vassilis Genoud, Eliana Marinari, +5 authors, Paul R Walker.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524896    Free PMC article.
Trial watch: Peptide-based vaccines in anticancer therapy.
Lucillia Bezu, Oliver Kepp, +6 authors, Lorenzo Galluzzi.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524907    Free PMC article.
Highly Cited. Review.
Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers.
Laurence C Menard, Paul Fischer, +8 authors, Steven G Nadler.
Front Immunol, 2018 Dec 12; 9. PMID: 30534127    Free PMC article.
HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy.
Tiziana Triulzi, Luca Forte, +6 authors, Elda Tagliabue.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546951    Free PMC article.
A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy.
Frederick S Varn, Yue Wang, Chao Cheng.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546953    Free PMC article.
Immunophenotypes of pancreatic ductal adenocarcinoma: Meta-analysis of transcriptional subtypes.
Ines de Santiago, Christopher Yau, +5 authors, Shivan Sivakumar.
Int J Cancer, 2019 Feb 06; 145(4). PMID: 30720864    Free PMC article.
Microsatellite instability in endometrial cancer: New purpose for an old test.
Katherine C Kurnit, Shannon N Westin, Robert L Coleman.
Cancer, 2019 Mar 27; 125(13). PMID: 30913308    Free PMC article.
Targeting immune cells for cancer therapy.
Sin Yee Gun, Sharon Wei Ling Lee, Je Lin Sieow, Siew Cheng Wong.
Redox Biol, 2019 Mar 29; 25. PMID: 30917934    Free PMC article.
Highly Cited. Review.
Bladder cancer, a unique model to understand cancer immunity and develop immunotherapy approaches.
Dongkui Song, Thomas Powles, +3 authors, Yong-Jie Lu.
J Pathol, 2019 May 19; 249(2). PMID: 31102277    Free PMC article.
The current state of molecular testing in the treatment of patients with solid tumors, 2019.
Wafik S El-Deiry, Richard M Goldberg, +10 authors, John L Marshall.
CA Cancer J Clin, 2019 May 23; 69(4). PMID: 31116423    Free PMC article.
Highly Cited. Review.
Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression.
Shenying Fang, Tao Xu, +12 authors, Jeffrey E Lee.
J Invest Dermatol, 2019 Jun 10; 139(11). PMID: 31176707    Free PMC article.
Epidemiologic perspectives on immunosuppressed populations and the immunosurveillance and immunocontainment of cancer.
Eric A Engels.
Am J Transplant, 2019 Jun 18; 19(12). PMID: 31206226    Free PMC article.
Precision neuroradiology: mapping the nodes and networks that link genes to behaviour.
Leo P Sugrue, Rahul S Desikan.
Br J Radiol, 2019 Jul 12; 92(1101). PMID: 31294609    Free PMC article.
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.
Joseph L Benci, Lexus R Johnson, +14 authors, Andy J Minn.
Cell, 2019 Aug 10; 178(4). PMID: 31398344    Free PMC article.
Highly Cited.
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors.
Sanjeevani Arora, Rodion Velichinskii, +6 authors, Yanis Boumber.
Adv Ther, 2019 Aug 15; 36(10). PMID: 31410780    Free PMC article.
Novel Biomarkers for Personalized Cancer Immunotherapy.
Yoshitaro Shindo, Shoichi Hazama, +2 authors, Hiroaki Nagano.
Cancers (Basel), 2019 Aug 25; 11(9). PMID: 31443339    Free PMC article.
Programmed Cell Death Ligand 1 in Breast Cancer: Technical Aspects, Prognostic Implications, and Predictive Value.
Federica Miglietta, Gaia Griguolo, Valentina Guarneri, Maria Vittoria Dieci.
Oncologist, 2019 Aug 25; 24(11). PMID: 31444294    Free PMC article.
The Systemic Treatment of Melanoma.
Patrick Terheyden, Angela Krackhardt, Thomas Eigentler.
Dtsch Arztebl Int, 2019 Aug 28; 116(29-30). PMID: 31452501    Free PMC article.
Single-Cell Transcriptome Analysis Reveals Gene Signatures Associated with T-cell Persistence Following Adoptive Cell Therapy.
Yong-Chen Lu, Li Jia, +3 authors, Steven A Rosenberg.
Cancer Immunol Res, 2019 Sep 06; 7(11). PMID: 31484655    Free PMC article.
Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy.
Shixiang Wang, Li An Cowley, Xue-Song Liu.
Molecules, 2019 Sep 07; 24(18). PMID: 31487832    Free PMC article.
Highly Cited. Review.
Panoptic View of Prognostic Models for Personalized Breast Cancer Management.
Geetanjali Saini, Karuna Mittal, +3 authors, Ritu Aneja.
Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500225    Free PMC article.
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma.
Yochai Wolf, Osnat Bartok, +26 authors, Yardena Samuels.
Cell, 2019 Sep 17; 179(1). PMID: 31522890    Free PMC article.
Highly Cited.
Matched Whole-Genome Sequencing (WGS) and Whole-Exome Sequencing (WES) of Tumor Tissue with Circulating Tumor DNA (ctDNA) Analysis: Complementary Modalities in Clinical Practice.
Robin Imperial, Marjan Nazer, +9 authors, Ashiq Masood.
Cancers (Basel), 2019 Sep 25; 11(9). PMID: 31546879    Free PMC article.
Review and perspective on adjuvant and neoadjuvant immunotherapies in NSCLC.
Chengxiang Yi, Yayi He, +2 authors, Peng Zhang.
Onco Targets Ther, 2019 Oct 01; 12. PMID: 31564915    Free PMC article.
Immunotherapy for head and neck cancer: where are we now and where are we going?
Joshua M Bauml, Charu Aggarwal, Roger B Cohen.
Ann Transl Med, 2019 Oct 03; 7(Suppl 3). PMID: 31576284    Free PMC article.
New insights in predictive determinants of the tumor immune microenvironment for immune checkpoint inhibition: a never ending story?
Markus Eckstein, Shilpa Gupta.
Ann Transl Med, 2019 Oct 03; 7(Suppl 3). PMID: 31576342    Free PMC article.
Unraveling the Heterogeneous Mutational Signature of Spontaneously Developing Tumors in MLH1-/- Mice.
Yvonne Saara Gladbach, Leonie Wiegele, +4 authors, Claudia Maletzki.
Cancers (Basel), 2019 Oct 05; 11(10). PMID: 31581674    Free PMC article.
High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma.
Kenneth H Buetow, Lydia R Meador, +6 authors, K Taraszka Hastings.
J Immunol, 2019 Oct 09; 203(10). PMID: 31591149    Free PMC article.
Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens.
Bas Weenink, Kaspar Draaisma, +4 authors, Pim J French.
Sci Rep, 2019 Oct 12; 9(1). PMID: 31601888    Free PMC article.
The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T-Cell Repertoire.
Shubhankar Nath, Girgis Obaid, Tayyaba Hasan.
Photochem Photobiol, 2019 Oct 12; 95(6). PMID: 31602649    Free PMC article.
Lynch syndrome-associated ultra-hypermutated pediatric glioblastoma mimicking a constitutional mismatch repair deficiency syndrome.
Chen Yang, Frances Austin, +5 authors, Scott A Turner.
Cold Spring Harb Mol Case Stud, 2019 Oct 13; 5(5). PMID: 31604779    Free PMC article.
Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade.
Lee P Richman, Robert H Vonderheide, Andrew J Rech.
Cell Syst, 2019 Oct 14; 9(4). PMID: 31606370    Free PMC article.
Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes.
Alena Gros, Eric Tran, +15 authors, Steven A Rosenberg.
J Clin Invest, 2019 Oct 15; 129(11). PMID: 31609250    Free PMC article.
Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers.
Hao-Xiang Wu, Yan-Xing Chen, +5 authors, Rui-Hua Xu.
J Immunother Cancer, 2019 Oct 19; 7(1). PMID: 31623662    Free PMC article.
Blood tumor mutational burden: are we ready for clinical implementation?
Claude Van Campenhout, Bárbara Meléndez, +2 authors, Nicky D'Haene.
J Thorac Dis, 2019 Oct 22; 11(Suppl 15). PMID: 31632782    Free PMC article.
MHC-II neoantigens shape tumour immunity and response to immunotherapy.
Elise Alspach, Danielle M Lussier, +20 authors, Robert D Schreiber.
Nature, 2019 Oct 28; 574(7780). PMID: 31645760    Free PMC article.
Highly Cited.
Clinicopathological correlation of immune response in human cancers.
Yuexin Liu.
Oncotarget, 2019 Oct 28; 10(56). PMID: 31645905    Free PMC article.
Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion.
Reshmi Tripathi, Vishnu Modur, +2 authors, Kakajan Komurov.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646083    Free PMC article.
Prognostic impact of the Controlling Nutritional Status score in patients with non-small cell lung cancer treated with pembrolizumab.
Taro Ohba, Shinkichi Takamori, +9 authors, Mitsuhiro Takenoyama.
J Thorac Dis, 2019 Oct 28; 11(9). PMID: 31656648    Free PMC article.
Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives.
E Krasniqi, G Barchiesi, +17 authors, P Vici.
J Hematol Oncol, 2019 Oct 31; 12(1). PMID: 31665051    Free PMC article.
pTuneos: prioritizing tumor neoantigens from next-generation sequencing data.
Chi Zhou, Zhiting Wei, +8 authors, Qi Liu.
Genome Med, 2019 Nov 02; 11(1). PMID: 31666118    Free PMC article.
Safety and Efficacy of Therapeutic Cancer Vaccines Alone or in Combination With Immune Checkpoint Inhibitors in Cancer Treatment.
Jing Zhao, Ye Chen, Zhen-Yu Ding, Ji-Yan Liu.
Front Pharmacol, 2019 Nov 05; 10. PMID: 31680963    Free PMC article.
Endogenous T cells prevent tumor immune escape following adoptive T cell therapy.
Scott R Walsh, Boris Simovic, +7 authors, Yonghong Wan.
J Clin Invest, 2019 Nov 05; 129(12). PMID: 31682239    Free PMC article.
Significant response to anti-PD-1 based immunotherapy plus lenvatinib for recurrent intrahepatic cholangiocarcinoma with bone metastasis: A case report and literature review.
Wei-Xun Chen, Gan-Xun Li, +3 authors, Ze-Yang Ding.
Medicine (Baltimore), 2019 Nov 09; 98(45). PMID: 31702638    Free PMC article.
Immune checkpoint inhibitor-associated gastrointestinal and hepatic adverse events and their management.
Uday N Shivaji, Louisa Jeffery, +5 authors, Marietta Iacucci.
Therap Adv Gastroenterol, 2019 Nov 15; 12. PMID: 31723355    Free PMC article.
Immune Checkpoint Inhibition in Hodgkin Lymphoma.
Ryan H Moy, Anas Younes.
Hemasphere, 2018 Feb 16; 2(1). PMID: 31723749    Free PMC article.
DeepHLApan: A Deep Learning Approach for Neoantigen Prediction Considering Both HLA-Peptide Binding and Immunogenicity.
Jingcheng Wu, Wenzhe Wang, +7 authors, Shuqing Chen.
Front Immunol, 2019 Nov 19; 10. PMID: 31736974    Free PMC article.
The Predictive Value of Tumor Mutation Burden on Efficacy of Immune Checkpoint Inhibitors in Cancers: A Systematic Review and Meta-Analysis.
Yongfeng Wu, Jinming Xu, +4 authors, Jian Hu.
Front Oncol, 2019 Nov 22; 9. PMID: 31750249    Free PMC article.
Systematic Review.
Tumor mutational burden in lung cancer: a systematic literature review.
Connor Willis, Michelle Fiander, +6 authors, David D Stenehjem.
Oncotarget, 2019 Nov 26; 10(61). PMID: 31762941    Free PMC article.
Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction.
Shixiang Wang, Zaoke He, +2 authors, Xue-Song Liu.
Elife, 2019 Nov 27; 8. PMID: 31767055    Free PMC article.
Lack of detectable neoantigen depletion signals in the untreated cancer genome.
Jimmy Van den Eynden, Alejandro Jiménez-Sánchez, Martin L Miller, Erik Larsson.
Nat Genet, 2019 Nov 27; 51(12). PMID: 31768072    Free PMC article.
Prostate Cancer Screening and Management in Solid Organ Transplant Candidates and Recipients.
Ezequiel Becher, Alex Wang, Herbert Lepor.
Rev Urol, 2019 Nov 27; 21(2-3). PMID: 31768135    Free PMC article.
Machine Learning for Cancer Immunotherapies Based on Epitope Recognition by T Cell Receptors.
Anja Mösch, Silke Raffegerst, +2 authors, Dmitrij Frishman.
Front Genet, 2019 Dec 05; 10. PMID: 31798635    Free PMC article.
Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor.
Xianguang Bai, Ming Yi, +2 authors, Kongming Wu.
Onco Targets Ther, 2019 Dec 07; 12. PMID: 31807028    Free PMC article.
Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response.
Elaine R Mardis.
Genome Med, 2019 Nov 22; 11(1). PMID: 31747945    Free PMC article.
Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic Implications.
Matthew J Ryan, Rohit Bose.
Front Oncol, 2019 Dec 12; 9. PMID: 31824860    Free PMC article.
Survival correlation of immune response in human cancers.
Yuexin Liu.
Oncotarget, 2019 Dec 17; 10(64). PMID: 31839882    Free PMC article.
Neoantigen Fitness Model Predicts Lower Immune Recognition of Cutaneous Squamous Cell Carcinomas Than Actinic Keratoses.
Elizabeth S Borden, Paul Kang, +4 authors, Karen Taraszka Hastings.
Front Immunol, 2019 Dec 19; 10. PMID: 31849976    Free PMC article.
Genetic instability as a driver for immune surveillance.
Guim Aguadé-Gorgorió, Ricard Solé.
J Immunother Cancer, 2019 Dec 13; 7(1). PMID: 31829285    Free PMC article.
Immunotherapy for acute myeloid leukemia: from allogeneic stem cell transplant to novel therapeutics.
David A Knorr, Aaron D Goldberg, Eytan M Stein, Martin S Tallman.
Leuk Lymphoma, 2019 Jul 25; 60(14). PMID: 31335250    Free PMC article.
Comprehensive Outline of Whole Exome Sequencing Data Analysis Tools Available in Clinical Oncology.
Áron Bartha, Balázs Győrffy.
Cancers (Basel), 2019 Nov 07; 11(11). PMID: 31690036    Free PMC article.
Tumor Mutational Burden and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.
Jong Yeob Kim, Andreas Kronbichler, +5 authors, Gabriele Gamerith.
Cancers (Basel), 2019 Nov 17; 11(11). PMID: 31731749    Free PMC article.
Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer.
Natalie I Vokes, David Liu, +19 authors, Mark M Awad.
JCO Precis Oncol, 2019 Dec 14; 3. PMID: 31832578    Free PMC article.
The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies.
Kroopa Joshi, Benjamin M Chain, Karl S Peggs, Sergio A Quezada.
Cold Spring Harb Perspect Med, 2017 Jun 21; 8(1). PMID: 28630228    Free PMC article.
Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4.
Jitske van den Bulk, Els M E Verdegaal, +12 authors, Noel F C C de Miranda.
Genome Med, 2020 Jan 01; 11(1). PMID: 31888734    Free PMC article.
Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors.
Wenyan Zhong, Jeremy S Myers, +11 authors, Paul A Rejto.
BMC Genomics, 2020 Jan 04; 21(1). PMID: 31898484    Free PMC article.
Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies.
Shetal A Patel, Andy J Minn.
Immunity, 2018 Mar 22; 48(3). PMID: 29562193    Free PMC article.
Highly Cited. Review.
Innovation in Oncology Drug Development.
Matthew Huber, Brian Huber.
J Oncol, 2020 Jan 09; 2019. PMID: 31911803    Free PMC article.
Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display.
Stina L Wickström, Tanja Lövgren, +14 authors, Rolf Kiessling.
Front Immunol, 2020 Jan 11; 10. PMID: 31921104    Free PMC article.
Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Rα Complexes Enhances Tumor Control.
Emilio Sanseviero, Erin M O'Brien, +16 authors, Erica L Stone.
Cancer Immunol Res, 2019 Jun 27; 7(8). PMID: 31239316    Free PMC article.
Molecular profiling for precision cancer therapies.
Eoghan R Malone, Marc Oliva, +2 authors, Lillian L Siu.
Genome Med, 2020 Jan 16; 12(1). PMID: 31937368    Free PMC article.
An Exon Signature to Estimate the Tumor Mutational Burden of Right-sided Colon Cancer Patients.
Wenbing Guo, Yelin Fu, +7 authors, Zheng Guo.
J Cancer, 2020 Jan 18; 11(4). PMID: 31949492    Free PMC article.
Tumor Mutational Burden as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors: A Review of Current Evidence.
Samuel J Klempner, David Fabrizio, +8 authors, Prasanth Reddy.
Oncologist, 2019 Oct 04; 25(1). PMID: 31578273    Free PMC article.
Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next-Generation Sequencing-Based Multiplex Gene Panel Assay.
Pham Nguyen Quy, Masashi Kanai, +16 authors, Manabu Muto.
Oncologist, 2019 Jun 13; 24(12). PMID: 31186376    Free PMC article.
pMHC Structural Comparisons as a Pivotal Element to Detect and Validate T-Cell Targets for Vaccine Development and Immunotherapy-A New Methodological Proposal.
Priscila Vianna, Marcus F A Mendes, +4 authors, Gustavo F Vieira.
Cells, 2019 Nov 27; 8(12). PMID: 31766602    Free PMC article.
Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma.
Deepak Perumal, Naoko Imai, +14 authors, Samir Parekh.
Clin Cancer Res, 2019 Dec 21; 26(2). PMID: 31857430    Free PMC article.
Rationale of Immunotherapy in Hepatocellular Carcinoma and Its Potential Biomarkers.
David Tai, Su Pin Choo, Valerie Chew.
Cancers (Basel), 2019 Dec 11; 11(12). PMID: 31816940    Free PMC article.
Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer.
Jenna H Newman, C Brent Chesson, +45 authors, Andrew Zloza.
Proc Natl Acad Sci U S A, 2020 Jan 01; 117(2). PMID: 31888983    Free PMC article.
Biomarkers Predictive of Survival and Response to Immune Checkpoint Inhibitors in Melanoma.
Emanuelle M Rizk, Angelina M Seffens, +5 authors, Yvonne M Saenger.
Am J Clin Dermatol, 2019 Oct 12; 21(1). PMID: 31602560    Free PMC article.
Identification of a CD8+ T-cell response to a predicted neoantigen in malignant mesothelioma.
Sophie Sneddon, Craig M Rive, +9 authors, Jenette Creaney.
Oncoimmunology, 2020 Feb 01; 9(1). PMID: 32002298    Free PMC article.
Pre-treatment tumor neo-antigen responses in draining lymph nodes are infrequent but predict checkpoint blockade therapy outcome.
Shaokang Ma, Jonathan Chee, +5 authors, Jenette Creaney.
Oncoimmunology, 2020 Feb 01; 9(1). PMID: 32002299    Free PMC article.
Targeted literature review on use of tumor mutational burden status and programmed cell death ligand 1 expression to predict outcomes of checkpoint inhibitor treatment.
Tina Krieger, Isobel Pearson, +2 authors, Paul Robbins.
Diagn Pathol, 2020 Feb 01; 15(1). PMID: 32000815    Free PMC article.
Comprehensive T cell repertoire characterization of non-small cell lung cancer.
Alexandre Reuben, Jiexin Zhang, +55 authors, Jianjun Zhang.
Nat Commun, 2020 Feb 01; 11(1). PMID: 32001676    Free PMC article.
High Somatic Mutation and Neoantigen Burden Do Not Correlate with Decreased Progression-Free Survival in HCC Patients not Undergoing Immunotherapy.
Angela Mauriello, Roberta Zeuli, +6 authors, Luigi Buonaguro.
Cancers (Basel), 2019 Nov 24; 11(12). PMID: 31756926    Free PMC article.
Promising Colorectal Cancer Biomarkers for Precision Prevention and Therapy.
Mimmo Turano, Paolo Delrio, +5 authors, Marina De Rosa.
Cancers (Basel), 2019 Dec 11; 11(12). PMID: 31817090    Free PMC article.
Tumor immune response and immunotherapy in gastric cancer.
Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee.
J Pathol Transl Med, 2019 Nov 02; 54(1). PMID: 31674166    Free PMC article.
Oncogene addiction and tumor mutational burden in non-small-cell lung cancer: Clinical significance and limitations.
Elisabeth Smolle, Katharina Leithner, Horst Olschewski.
Thorac Cancer, 2019 Dec 05; 11(2). PMID: 31799812    Free PMC article.
Gut Microbiome as a Potential Factor for Modulating Resistance to Cancer Immunotherapy.
Lin Shui, Xi Yang, +3 authors, Hong Zhu.
Front Immunol, 2020 Feb 06; 10. PMID: 32010123    Free PMC article.
Neoantigens from the bench to the bedside: new prospective for ovarian cancer immunotherapy.
Chiara Napoletano, Filippo Bellati.
Ann Transl Med, 2020 Feb 06; 7(Suppl 8). PMID: 32016024    Free PMC article.
Mutated RAS: Targeting the "Untargetable" with T Cells.
Praveen D Chatani, James C Yang.
Clin Cancer Res, 2019 Sep 13; 26(3). PMID: 31511296    Free PMC article.
Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade.
Julie E Stein, Evan J Lipson, +12 authors, Janis M Taube.
Clin Cancer Res, 2019 Nov 02; 26(3). PMID: 31672770    Free PMC article.
Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K BRAF-Mutant Melanoma.
Inês Pires da Silva, Kevin Y X Wang, +16 authors, Alexander M Menzies.
Clin Cancer Res, 2019 Jan 12; 25(4). PMID: 30630828    Free PMC article.
Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies.
Hongxing Shen, Eddy Shih-Hsin Yang, +4 authors, Lewis Zhichang Shi.
Genes Dis, 2020 Feb 12; 6(3). PMID: 32042863    Free PMC article.
Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses.
Anthony E Zamora, Jeremy Chase Crawford, +17 authors, Paul G Thomas.
Sci Transl Med, 2019 Jun 28; 11(498). PMID: 31243155    Free PMC article.
Advancing Biomarker Development Through Convergent Engagement: Summary Report of the 2nd International Danube Symposium on Biomarker Development, Molecular Imaging and Applied Diagnostics; March 14-16, 2018; Vienna, Austria.
M S Lim, Thomas Beyer, +25 authors, M Hacker.
Mol Imaging Biol, 2019 May 03; 22(1). PMID: 31049831
Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML.
Fabiana Perna, Samuel H Berman, +6 authors, Michel Sadelain.
Cancer Cell, 2017 Oct 11; 32(4). PMID: 29017060    Free PMC article.
Highly Cited.