Congress
. 2014 Dec; 10(10):3090-100.
doi: 10.4161/hv.29767.

CIMT 2014: Next waves in cancer immunotherapy--report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany

Mustafa Diken 1 Sebastian Boegel  Christian Grunwitz  Lena M Kranz  Kerstin Reuter  Niels van de Roemer  Fulvia Vascotto  Mathias Vormehr  Sebastian Kreiter  
Affiliations
  • PMID: 25483671
  •     106 References

No abstract available

Keywords: CIMT; Cancer immunotherapy; cellular therapy; combination; immunomonitoring; tumor microenvironment; tumor vaccination.

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Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets.
Bruno Salaun, Takuya Yamamoto, +14 authors, Pedro Romero.
J Transl Med, 2011 Apr 22; 9. PMID: 21507256    Free PMC article.
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
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Proc Natl Acad Sci U S A, 2010 Feb 18; 107(9). PMID: 20160101    Free PMC article.
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NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11.
Claus Lundegaard, Kasper Lamberth, +3 authors, Morten Nielsen.
Nucleic Acids Res, 2008 May 09; 36(Web Server issue). PMID: 18463140    Free PMC article.
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Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells.
Silke Holtkamp, Sebastian Kreiter, +5 authors, Ugur Sahin.
Blood, 2006 Aug 31; 108(13). PMID: 16940422
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Magdalena Paolino, Axel Choidas, +21 authors, Josef M Penninger.
Nature, 2014 Feb 21; 507(7493). PMID: 24553136    Free PMC article.
Highly Cited.
Utilizing TH9 cells as a novel therapeutic strategy for malignancies.
Yong Lu, Qing Yi.
Oncoimmunology, 2013 Jun 27; 2(3). PMID: 23802062    Free PMC article.
NetCTLpan: pan-specific MHC class I pathway epitope predictions.
Thomas Stranzl, Mette Voldby Larsen, Claus Lundegaard, Morten Nielsen.
Immunogenetics, 2010 Apr 10; 62(6). PMID: 20379710    Free PMC article.
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Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Robert Besch, Hendrik Poeck, +8 authors, Gunther Hartmann.
J Clin Invest, 2009 Jul 22; 119(8). PMID: 19620789    Free PMC article.
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Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
Daniel Schramek, Andreas Leibbrandt, +13 authors, Josef M Penninger.
Nature, 2010 Oct 01; 468(7320). PMID: 20881962    Free PMC article.
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Galaxy LIMS for next-generation sequencing.
Jelle Scholtalbers, Jasmin Rößler, +4 authors, Ugur Sahin.
Bioinformatics, 2013 Mar 13; 29(9). PMID: 23479349
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells.
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J Exp Med, 2006 Jun 28; 203(7). PMID: 16801397    Free PMC article.
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Kasper W Jørgensen, Michael Rasmussen, Søren Buus, Morten Nielsen.
Immunology, 2013 Aug 10; 141(1). PMID: 23927693    Free PMC article.
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Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain.
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J Immunol, 2003 Dec 23; 172(1). PMID: 14688315
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N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127    Free PMC article.
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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Martin Schlee, Andreas Roth, +18 authors, Gunther Hartmann.
Immunity, 2009 Jul 07; 31(1). PMID: 19576794    Free PMC article.
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Mutated tumor alleles are expressed according to their DNA frequency.
John C Castle, Martin Loewer, +8 authors, Ugur Sahin.
Sci Rep, 2014 Apr 23; 4. PMID: 24752137    Free PMC article.
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy.
Ronald J Buckanovich, Andrea Facciabene, +7 authors, George Coukos.
Nat Med, 2007 Dec 25; 14(1). PMID: 18157142
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Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo.
A N Kuhn, M Diken, +7 authors, U Sahin.
Gene Ther, 2010 Apr 23; 17(8). PMID: 20410931
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.
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Proc Natl Acad Sci U S A, 2010 Feb 06; 107(7). PMID: 20133621    Free PMC article.
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Regulation of cancer cell migration and bone metastasis by RANKL.
D Holstead Jones, Tomoki Nakashima, +15 authors, Josef M Penninger.
Nature, 2006 Mar 31; 440(7084). PMID: 16572175
Highly Cited.
γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia.
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Leukemia, 2013 Jan 02; 27(6). PMID: 23277330
Highly Cited.
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
D M Anderson, E Maraskovsky, +7 authors, L Galibert.
Nature, 1997 Nov 21; 390(6656). PMID: 9367155
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Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect.
Mariola Fotin-Mleczek, Kai Zanzinger, +4 authors, Karl-Josef Kallen.
J Gene Med, 2012 Jan 21; 14(6). PMID: 22262664
The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions.
Christopher J Chan, Ludovic Martinet, +7 authors, Mark J Smyth.
Nat Immunol, 2014 Mar 25; 15(5). PMID: 24658051
Highly Cited.
Turning tumors into vaccines: co-opting the innate immune system.
Jasper G van den Boorn, Gunther Hartmann.
Immunity, 2013 Jul 31; 39(1). PMID: 23890061
Review.
Molecular control of bone remodeling and osteoporosis.
Y Y Kong, J M Penninger.
Exp Gerontol, 2000 Dec 21; 35(8). PMID: 11121682
Review.
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
Jan C Dudda, Bruno Salaun, +16 authors, Pedro Romero.
Immunity, 2013 Apr 23; 38(4). PMID: 23601686    Free PMC article.
Highly Cited.
Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity.
Sebastian Kreiter, Abderraouf Selmi, +5 authors, Ugur Sahin.
Cancer Res, 2010 Nov 04; 70(22). PMID: 21045153
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells.
Stefanie Loeser, Karin Loser, +6 authors, Josef M Penninger.
J Exp Med, 2007 Apr 04; 204(4). PMID: 17403934    Free PMC article.
Targeting natural killer cells and natural killer T cells in cancer.
Eric Vivier, Sophie Ugolini, +2 authors, Laurent Brossay.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437937    Free PMC article.
Highly Cited. Review.
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma.
John C Castle, Martin Loewer, +11 authors, Ugur Sahin.
BMC Genomics, 2014 Mar 14; 15. PMID: 24621249    Free PMC article.
Highly Cited.
Tuning the threshold of natural killer cell responses.
Emilie Narni-Mancinelli, Sophie Ugolini, Eric Vivier.
Curr Opin Immunol, 2012 Dec 29; 25(1). PMID: 23270590
Review.
Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals.
Sebastian Kreiter, Abderraouf Selmi, +6 authors, Ugur Sahin.
J Immunol, 2007 Dec 22; 180(1). PMID: 18097032
γ9 and δ2CDR3 domains regulate functional avidity of T cells harboring γ9δ2TCRs.
Cordula Gründer, Suzanne van Dorp, +9 authors, Jürgen Kuball.
Blood, 2012 Sep 29; 120(26). PMID: 23018643
Adoptive immunotherapy for cancer: harnessing the T cell response.
Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939    Free PMC article.
Highly Cited. Review.
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.
Stephan A Grupp, Michael Kalos, +10 authors, Carl H June.
N Engl J Med, 2013 Mar 27; 368(16). PMID: 23527958    Free PMC article.
Highly Cited.
Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols.
Helene Filbert, Sebastian Attig, +8 authors, Cedrik M Britten.
Cancer Immunol Immunother, 2012 Nov 10; 62(4). PMID: 23138872    Free PMC article.
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
J E Fata, Y Y Kong, +10 authors, J M Penninger.
Cell, 2000 Oct 29; 103(1). PMID: 11051546
Highly Cited.
Redirecting αβ T cells against cancer cells by transfer of a broadly tumor-reactive γδT-cell receptor.
Victoria Marcu-Malina, Sabine Heijhuurs, +6 authors, Jürgen Kuball.
Blood, 2011 May 14; 118(1). PMID: 21566093
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers.
Yong Lu, Bangxing Hong, +5 authors, Qing Yi.
Proc Natl Acad Sci U S A, 2014 Jan 29; 111(6). PMID: 24469818    Free PMC article.
A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols.
Sebastian Attig, Leah Price, +10 authors, CRI-CIC Assay Working Group.
J Transl Med, 2011 Jul 13; 9. PMID: 21745365    Free PMC article.
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.
David L Porter, Bruce L Levine, +2 authors, Carl H June.
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Highly Cited.
Improved survival with ipilimumab in patients with metastatic melanoma.
F Stephen Hodi, Steven J O'Day, +26 authors, Walter J Urba.
N Engl J Med, 2010 Jun 08; 363(8). PMID: 20525992    Free PMC article.
Highly Cited.
Mitigating the toxic effects of anticancer immunotherapy.
Tara C Gangadhar, Robert H Vonderheide.
Nat Rev Clin Oncol, 2014 Jan 22; 11(2). PMID: 24445516
Highly Cited. Review.
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.
David L Lacey, William J Boyle, +5 authors, Roger Dansey.
Nat Rev Drug Discov, 2012 May 01; 11(5). PMID: 22543469
Highly Cited. Review.
Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion.
Yared Hailemichael, Zhimin Dai, +17 authors, Willem W Overwijk.
Nat Med, 2013 Mar 05; 19(4). PMID: 23455713    Free PMC article.
Highly Cited.
Effective tumor immunotherapy: start the engine, release the brakes, step on the gas pedal,...and get ready to face autoimmunity.
Iñigo Tirapu, Guillermo Mazzolini, +4 authors, Ignacio Melero.
Arch Immunol Ther Exp (Warsz), 2002 Mar 28; 50(1). PMID: 11916305
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Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.
Jacques E Rossouw, Garnet L Anderson, +10 authors, Writing Group for the Women's Health Initiative Investigators.
JAMA, 2002 Jul 19; 288(3). PMID: 12117397
Highly Cited.
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Jorg J A Calis, Matt Maybeno, +5 authors, Bjoern Peters.
PLoS Comput Biol, 2013 Nov 10; 9(10). PMID: 24204222    Free PMC article.
Highly Cited.
Unifying immunology with informatics and multiscale biology.
Brian A Kidd, Lauren A Peters, Eric E Schadt, Joel T Dudley.
Nat Immunol, 2014 Jan 23; 15(2). PMID: 24448569    Free PMC article.
Highly Cited. Review.
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
Eva Gonzalez-Suarez, Allison P Jacob, +6 authors, William C Dougall.
Nature, 2010 Oct 01; 468(7320). PMID: 20881963
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Cancer Res, 2012 Feb 18; 72(7). PMID: 22337996
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Michael A Curran, Myoungjoo Kim, +2 authors, James P Allison.
PLoS One, 2011 May 12; 6(4). PMID: 21559358    Free PMC article.
Highly Cited.
Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform.
Biserka Mulac-Jericevic, John P Lydon, Francesco J DeMayo, Orla M Conneely.
Proc Natl Acad Sci U S A, 2003 Aug 05; 100(17). PMID: 12897242    Free PMC article.
Highly Cited.
Identification of CDCA1-derived long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients.
Yusuke Tomita, Akira Yuno, +15 authors, Yasuharu Nishimura.
Int J Cancer, 2014 Apr 16; 134(2). PMID: 24734272
RANK is essential for osteoclast and lymph node development.
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PLoS One, 2007 Aug 30; 2(8). PMID: 17726526    Free PMC article.
Highly Cited.
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Michael C Milone, Jonathan D Fish, +11 authors, Carl H June.
Mol Ther, 2009 Apr 23; 17(8). PMID: 19384291    Free PMC article.
Highly Cited.
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Immunogenetics, 2013 Aug 01; 65(10). PMID: 23900783    Free PMC article.
Highly Cited.
Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity.
Mariola Fotin-Mleczek, Katharina M Duchardt, +4 authors, Karl-Josef Kallen.
J Immunother, 2010 Dec 15; 34(1). PMID: 21150709
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Reiko Hanada, Andreas Leibbrandt, +19 authors, Josef M Penninger.
Nature, 2009 Nov 27; 462(7272). PMID: 19940926
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Eur J Immunol, 2012 Jun 09; 42(6). PMID: 22678897
Th9 cells promote antitumor immune responses in vivo.
Yong Lu, Sungyoul Hong, +10 authors, Qing Yi.
J Clin Invest, 2012 Oct 16; 122(11). PMID: 23064366    Free PMC article.
Highly Cited.
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.
Laure Gineau, Céline Cognet, +17 authors, Emmanuelle Jouanguy.
J Clin Invest, 2012 Feb 23; 122(3). PMID: 22354167    Free PMC article.
Highly Cited.
A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission.
Norbert Vey, Jean-Henri Bourhis, +9 authors, Daniel Olive.
Blood, 2012 Sep 25; 120(22). PMID: 23002117
Highly Cited.
Long peptide-based cancer immunotherapy targeting tumor antigen-specific CD4+ and CD8+ T cells.
Yusuke Tomita, Yasuharu Nishimura.
Oncoimmunology, 2013 Dec 12; 2(9). PMID: 24327937    Free PMC article.
NetTepi: an integrated method for the prediction of T cell epitopes.
Thomas Trolle, Morten Nielsen.
Immunogenetics, 2014 May 28; 66(7-8). PMID: 24863339
Cancer immunotherapy comes of age.
Ira Mellman, George Coukos, Glenn Dranoff.
Nature, 2011 Dec 24; 480(7378). PMID: 22193102    Free PMC article.
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Eur J Immunol, 1999 Dec 22; 30(1). PMID: 10602021
Tumor vaccination using messenger RNA: prospects of a future therapy.
Sebastian Kreiter, Mustafa Diken, +2 authors, Ugur Sahin.
Curr Opin Immunol, 2011 Apr 19; 23(3). PMID: 21497074
Review.
Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects.
R T Mitsuyasu, P A Anton, +10 authors, K M Hege.
Blood, 2000 Jul 27; 96(3). PMID: 10910888
Highly Cited.
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
Gregory T Motz, Stephen P Santoro, +7 authors, George Coukos.
Nat Med, 2014 May 06; 20(6). PMID: 24793239    Free PMC article.
Highly Cited.
Innate lymphoid cells--a proposal for uniform nomenclature.
Hergen Spits, David Artis, +9 authors, Eric Vivier.
Nat Rev Immunol, 2013 Jan 26; 13(2). PMID: 23348417
Highly Cited. Review.
Role of RANKL and RANK in bone loss and arthritis.
D Holstead Jones, Y-Y Kong, J M Penninger.
Ann Rheum Dis, 2002 Oct 16; 61 Suppl 2. PMID: 12379618    Free PMC article.
Review.
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.
Myung-Shin Jeon, Alex Atfield, +16 authors, Josef M Penninger.
Immunity, 2004 Aug 17; 21(2). PMID: 15308098
Highly Cited.
HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity.
Sinu Paul, Daniela Weiskopf, +3 authors, Alessandro Sette.
J Immunol, 2013 Nov 06; 191(12). PMID: 24190657    Free PMC article.
Highly Cited.
The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage.
Morten Nielsen, Claus Lundegaard, Ole Lund, Can Keşmir.
Immunogenetics, 2005 Mar 04; 57(1-2). PMID: 15744535
Highly Cited.
Breakthrough of the year 2013. Cancer immunotherapy.
Jennifer Couzin-Frankel.
Science, 2013 Dec 21; 342(6165). PMID: 24357284
Highly Cited.
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells.
John Scholler, Troy L Brady, +13 authors, Carl H June.
Sci Transl Med, 2012 May 04; 4(132). PMID: 22553251    Free PMC article.
Highly Cited.
T cell assays and MIATA: the essential minimum for maximum impact.
C M Britten, S Janetzki, +20 authors, M M Davis.
Immunity, 2012 Jul 31; 37(1). PMID: 22840835
Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155).
Anja Fuchs, Marina Cella, +2 authors, Marco Colonna.
J Immunol, 2004 Mar 23; 172(7). PMID: 15034010
Highly Cited.
Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies.
Holbrook E Kohrt, Ariane Thielens, +14 authors, Pascale André.
Blood, 2013 Dec 12; 123(5). PMID: 24326534    Free PMC article.
Highly Cited.
Discovery and preclinical validation of drug indications using compendia of public gene expression data.
Marina Sirota, Joel T Dudley, +5 authors, Atul J Butte.
Sci Transl Med, 2011 Aug 19; 3(96). PMID: 21849665    Free PMC article.
Highly Cited.
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.
Michael Kalos, Bruce L Levine, +4 authors, Carl H June.
Sci Transl Med, 2011 Aug 13; 3(95). PMID: 21832238    Free PMC article.
Highly Cited.
Targeted immunotherapy of cancer with CAR T cells: achievements and challenges.
Grazyna Lipowska-Bhalla, David E Gilham, Robert E Hawkins, Dominic G Rothwell.
Cancer Immunol Immunother, 2012 Apr 25; 61(7). PMID: 22527245
Review.
Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin.
Michael A Curran, Theresa L Geiger, +5 authors, James P Allison.
J Exp Med, 2013 Apr 03; 210(4). PMID: 23547098    Free PMC article.
Highly Cited.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
Stefano Vavassori, Anil Kumar, +14 authors, Gennaro De Libero.
Nat Immunol, 2013 Jul 23; 14(9). PMID: 23872678
Highly Cited.
The speed of change: towards a discontinuity theory of immunity?
Thomas Pradeu, Sébastien Jaeger, Eric Vivier.
Nat Rev Immunol, 2013 Sep 03; 13(10). PMID: 23995627
Review.
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Y Y Kong, H Yoshida, +14 authors, J M Penninger.
Nature, 1999 Feb 09; 397(6717). PMID: 9950424
Highly Cited.
HLA typing from RNA-Seq sequence reads.
Sebastian Boegel, Martin Löwer, +7 authors, Ugur Sahin.
Genome Med, 2012 Dec 25; 4(12). PMID: 23259685    Free PMC article.
Highly Cited.
Exosomes as nucleic acid nanocarriers.
Jasper G van den Boorn, Juliane Dassler, +2 authors, Gunther Hartmann.
Adv Drug Deliv Rev, 2012 Jul 04; 65(3). PMID: 22750807
Review.
Peptide and dendritic cell vaccines.
Craig L Slingluff, Victor H Engelhard, Soldano Ferrone.
Clin Cancer Res, 2006 Apr 13; 12(7 Pt 2). PMID: 16609056
Review.
Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity.
Ergun Kocak, Kenneth Lute, +8 authors, Yang Liu.
Cancer Res, 2006 Jul 20; 66(14). PMID: 16849577
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.
Sophie Viaud, Fabiana Saccheri, +30 authors, Laurence Zitvogel.
Science, 2013 Nov 23; 342(6161). PMID: 24264990    Free PMC article.
Highly Cited.
Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer.
S A Quezada, K S Peggs.
Br J Cancer, 2013 Mar 21; 108(8). PMID: 23511566    Free PMC article.
NNAlign: a web-based prediction method allowing non-expert end-user discovery of sequence motifs in quantitative peptide data.
Massimo Andreatta, Claus Schafer-Nielsen, +2 authors, Morten Nielsen.
PLoS One, 2011 Nov 11; 6(11). PMID: 22073191    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Exploiting the mutanome for tumor vaccination.
John C Castle, Sebastian Kreiter, +13 authors, Ugur Sahin.
Cancer Res, 2012 Jan 13; 72(5). PMID: 22237626
Highly Cited.
NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction.
Morten Nielsen, Ole Lund.
BMC Bioinformatics, 2009 Sep 22; 10. PMID: 19765293    Free PMC article.
Highly Cited.
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
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Cancer Discov, 2013 Oct 01; 3(12). PMID: 24078773    Free PMC article.
Highly Cited.
Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor.
Yusuke Tomita, Akira Yuno, +15 authors, Yasuharu Nishimura.
Clin Cancer Res, 2013 May 30; 19(16). PMID: 23714729
Systematic functional regulatory assessment of disease-associated variants.
Konrad J Karczewski, Joel T Dudley, +4 authors, Michael Snyder.
Proc Natl Acad Sci U S A, 2013 May 22; 110(23). PMID: 23690573    Free PMC article.
The development of denosumab for the treatment of diseases of bone loss and cancer-induced bone destruction.
Carsten Goessl, Leonid Katz, +5 authors, Rachel B Wagman.
Ann N Y Acad Sci, 2012 Jul 27; 1263. PMID: 22831177
Review.