Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair

Dietmar M W Zaiss ¹, William C Gause ², Lisa C Osborne ³, David Artis ⁴

Affiliations

¹ Ashworth Laboratories, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3FL, UK. Electronic address: dietmar.zaiss@ed.ac.uk.
² Department of Medicine, Center for Immunity and Inflammation, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ 07101, USA. Electronic address: gausewc@njms.rutgers.edu.
³ Jill Roberts Institute for Research in IBD, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.
⁴ Jill Roberts Institute for Research in IBD, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA. Electronic address: dartis@med.cornell.edu.

PMID: 25692699
116 References
192 citations

Abstract

Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms, allergens, and infectious agents, and play critical roles in resistance and tolerance associated with infection, wound healing, tissue repair, and tumor development. Emerging data suggest that in addition to characteristic type 2-associated cytokines, the epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of type 2-mediated resistance and tolerance. Notably, numerous studies demonstrate that in addition to the established role of epithelial- and mesenchymal-derived AREG, multiple leukocyte populations including mast cells, basophils, group 2 innate lymphoid cells (ILC2s), and a subset of tissue-resident regulatory CD4(+) T cells can express AREG. In this review, we discuss recent advances in our understanding of the AREG-EGF receptor pathway and its involvement in infection and inflammation and propose a model for the function of this pathway in the context of resistance and tissue tolerance.

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References
Amphiregulin production by human eosinophils. Kenji Matsumoto, Shuhei Fukuda, Yuri Nakamura, Hirohisa Saito. Int Arch Allergy Immunol, 2009 Jun 12; 149 Suppl 1. PMID: 19494503
Epidermal EGFR controls cutaneous host defense and prevents inflammation. Beate M Lichtenberger, Peter A Gerber, +15 authors, Maria Sibilia. less Sci Transl Med, 2013 Aug 24; 5(199). PMID: 23966300 Highly Cited.
Modulation of the receptor binding affinity of amphiregulin by modification of its carboxyl terminal tail. R Adam, D R Drummond, +4 authors, D E Davies. less Biochim Biophys Acta, 1995 Apr 06; 1266(1). PMID: 7718625
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J Marshall. Cell, 1995 Jan 27; 80(2). PMID: 7834738 Highly Cited. Review.
Allergic host defences. Noah W Palm, Rachel K Rosenstein, Ruslan Medzhitov. Nature, 2012 Apr 28; 484(7395). PMID: 22538607 Free PMC article. Highly Cited.
Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis. Yang Zhou, Jae-Young Lee, +8 authors, Chun Geun Lee. less J Biol Chem, 2012 Oct 23; 287(50). PMID: 23086930 Free PMC article.
Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression. Chantal Meulenbroeks, Huib van Weelden, +6 authors, Dietmar M W Zaiss. less J Invest Dermatol, 2014 Aug 05; 135(1). PMID: 25089660
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. Tao Zheng, Wei Liu, +6 authors, Jack A Elias. less J Immunol, 2007 Dec 22; 180(1). PMID: 18097054
Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. Monica G Chiaramonte, Margaret Mentink-Kane, +8 authors, Thomas A Wynn. less J Exp Med, 2003 Mar 19; 197(6). PMID: 12642601 Free PMC article.
Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation. L Schuger, G R Johnson, +2 authors, K Gilbride, G D Plowman, R Mandel. less Development, 1996 Jun 01; 122(6). PMID: 8674415
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. Maryam Salimi, Jillian L Barlow, +9 authors, Graham S Ogg. less J Exp Med, 2013 Dec 11; 210(13). PMID: 24323357 Free PMC article. Highly Cited.
Human keratinocytes' response to injury upregulates CCL20 and other genes linking innate and adaptive immunity. Milène Kennedy-Crispin, Erika Billick, +7 authors, James G Krueger. less J Invest Dermatol, 2011 Sep 02; 132(1). PMID: 21881590 Free PMC article.
Mast cells are essential intermediaries in regulatory T-cell tolerance. Li-Fan Lu, Evan F Lind, +10 authors, Randolph J Noelle. less Nature, 2006 Aug 22; 442(7106). PMID: 16921386 Highly Cited.
Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice. Naoki Kajiwara, Keisuke Oboki, +5 authors, Susumu Nakae. less Allergol Int, 2010 Apr 24; 59(2). PMID: 20414053
Regulation of amphiregulin mRNA by TGF-beta in the human lung adenocarcinoma cell line A549. K L Bennett, G D Plowman, +2 authors, S D Buckley, J Skonier, A F Purchio. less Growth Factors, 1992 Jan 01; 7(3). PMID: 1457126
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Jose E Heredia, Lata Mukundan, +5 authors, Ajay Chawla. less Cell, 2013 Apr 16; 153(2). PMID: 23582327 Free PMC article. Highly Cited.
IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. Jan-Eric Turner, Peter J Morrison, +6 authors, Brigitta Stockinger. less J Exp Med, 2013 Nov 20; 210(13). PMID: 24249111 Free PMC article. Highly Cited.
Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation. Jennifer L Macdonald-Obermann, Linda J Pike. J Biol Chem, 2014 Aug 03; 289(38). PMID: 25086039 Free PMC article.
Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts. Shen-Wu Wang, Chad K Oh, +6 authors, Zhengbin Yao. less J Allergy Clin Immunol, 2005 Feb 08; 115(2). PMID: 15696083
Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. Michiyo Yamada, Yasushi Ichikawa, +7 authors, Hiroshi Shimada. less Clin Cancer Res, 2008 Apr 17; 14(8). PMID: 18413824
Muc5ac: a critical component mediating the rejection of enteric nematodes. Sumaira Z Hasnain, Christopher M Evans, +8 authors, David J Thornton. less J Exp Med, 2011 Apr 20; 208(5). PMID: 21502330 Free PMC article. Highly Cited.
Distinct effects of EGFR ligands on human mammary epithelial cell differentiation. Chandrani Mukhopadhyay, Xiangshan Zhao, +2 authors, Dulce Maroni, Vimla Band, Mayumi Naramura. less PLoS One, 2013 Oct 15; 8(10). PMID: 24124521 Free PMC article.
Inflammatory cells during wound repair: the good, the bad and the ugly. Paul Martin, S Joseph Leibovich. Trends Cell Biol, 2005 Oct 06; 15(11). PMID: 16202600 Highly Cited. Review.
Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. Nandini Krishnamoorthy, Patrick R Burkett, +8 authors, Bruce D Levy. less J Immunol, 2014 Dec 30; 194(3). PMID: 25539814 Free PMC article. Highly Cited.
Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Timothy D Le Cras, Thomas H Acciani, +10 authors, Gurjit K Khurana Hershey. less Am J Physiol Lung Cell Mol Physiol, 2011 Jan 13; 300(3). PMID: 21224214 Free PMC article.
Feedback regulation of EGFR signalling: decision making by early and delayed loops. Roi Avraham, Yosef Yarden. Nat Rev Mol Cell Biol, 2011 Jan 22; 12(2). PMID: 21252999 Highly Cited. Review.
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells. Isobel S Okoye, Stephanie M Coomes, +5 authors, Mark S Wilson. less Immunity, 2014 Jul 19; 41(1). PMID: 25035954 Free PMC article. Highly Cited.
FcepsilonRI-mediated amphiregulin production by human mast cells increases mucin gene expression in epithelial cells. Shigeru Okumura, Hironori Sagara, +2 authors, Takeshi Fukuda, Hirohisa Saito, Yoshimichi Okayama. less J Allergy Clin Immunol, 2005 Feb 08; 115(2). PMID: 15696081
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. Maria J Perugorria, M Ujue Latasa, +9 authors, Matias A Avila. less Hepatology, 2008 Jul 18; 48(4). PMID: 18634036
IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. Steven A Saenz, Mark C Siracusa, +8 authors, David Artis. less J Exp Med, 2013 Aug 21; 210(9). PMID: 23960191 Free PMC article. Highly Cited.
Amphiregulin promotes the immunosuppressive activity of intrahepatic CD4+ regulatory T cells to impair CD8+ T-cell immunity against hepatitis B virus infection. Kai Dai, Ling Huang, +2 authors, Jing Chen, Lihua Yang, Zuojiong Gong. less Immunology, 2014 Oct 10; 144(3). PMID: 25298208 Free PMC article.
IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Emily Hams, Michelle E Armstrong, +11 authors, Padraic G Fallon. less Proc Natl Acad Sci U S A, 2013 Dec 18; 111(1). PMID: 24344271 Free PMC article. Highly Cited.
Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Michele A Grimbaldeston, Susumu Nakae, +2 authors, Janet Kalesnikoff, Mindy Tsai, Stephen J Galli. less Nat Immunol, 2007 Sep 04; 8(10). PMID: 17767162 Highly Cited.
Neutrophils in cystic fibrosis display a distinct gene expression pattern. Minou Adib-Conquy, Thierry Pedron, +5 authors, Jean-Marc Cavaillon. less Mol Med, 2007 Nov 21; 14(1-2). PMID: 18026571 Free PMC article.
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Mark C Siracusa, Steven A Saenz, +14 authors, David Artis. less Nature, 2011 Aug 16; 477(7363). PMID: 21841801 Free PMC article. Highly Cited.
IL-13 signaling via IL-13Rα2 triggers TGF-β1-dependent allograft fibrosis. Stefan M Brunner, Gabriela Schiechl, +5 authors, Stefan Fichtner-Feigl. less Transplant Res, 2013 Oct 23; 2(1). PMID: 24143891 Free PMC article.
New paradigms in type 2 immunity. Bali Pulendran, David Artis. Science, 2012 Jul 28; 337(6093). PMID: 22837519 Free PMC article. Highly Cited. Review.
Amphiregulin. Carmen Berasain, Matías A Avila. Semin Cell Dev Biol, 2014 Jan 28; 28. PMID: 24463227 Highly Cited. Review.
A2B adenosine receptor induces protective antihelminth type 2 immune responses. Nirav Patel, Wenhui Wu, +7 authors, William C Gause. less Cell Host Microbe, 2014 Mar 19; 15(3). PMID: 24629340
Encoding and decoding cellular information through signaling dynamics. Jeremy E Purvis, Galit Lahav. Cell, 2013 Mar 05; 152(5). PMID: 23452846 Free PMC article. Highly Cited. Review.
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. P'ng Loke, Iain Gallagher, +5 authors, Judith E Allen. less J Immunol, 2007 Sep 06; 179(6). PMID: 17785830 Highly Cited.
Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin. Jinyi Shao, Sean B Lee, +2 authors, Huiping Guo, B Mark Evers, Hongmiao Sheng. less Cancer Res, 2003 Sep 23; 63(17). PMID: 14500348
ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. Carlos L Arteaga, Jeffrey A Engelman. Cancer Cell, 2014 Mar 22; 25(3). PMID: 24651011 Free PMC article. Highly Cited. Review.
Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells. S Li, G D Plowman, S D Buckley, G D Shipley. J Cell Physiol, 1992 Oct 01; 153(1). PMID: 1522124
Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Itaru Imayoshi, Akihiro Isomura, +6 authors, Ryoichiro Kageyama. less Science, 2013 Nov 02; 342(6163). PMID: 24179156 Highly Cited.
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. De'Broski R Herbert, Jun-Qi Yang, +10 authors, Fred D Finkelman. less J Exp Med, 2009 Dec 10; 206(13). PMID: 19995957 Free PMC article. Highly Cited.
The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin. Yilin Qi, Darwin J Operario, Steve N Georas, Tim R Mosmann. PLoS One, 2012 Jun 22; 7(6). PMID: 22720031 Free PMC article.
Amphiregulin is not essential for induction of contact hypersensitivity. Akiko Yagami, Naoki Kajiwara, +7 authors, Susumu Nakae. less Allergol Int, 2010 Jun 23; 59(3). PMID: 20567134
Disease tolerance as a defense strategy. Ruslan Medzhitov, David S Schneider, Miguel P Soares. Science, 2012 Mar 01; 335(6071). PMID: 22363001 Free PMC article. Highly Cited. Review.
Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis. Bernice Y Kwong, Scott J Roberts, +9 authors, Michael Girardi. less J Invest Dermatol, 2009 Nov 20; 130(6). PMID: 19924136 Free PMC article.
Amphiregulin: an early trigger of liver regeneration in mice. Carmen Berasain, Elena R García-Trevijano, +4 authors, Matías A Avila. less Gastroenterology, 2005 Feb 03; 128(2). PMID: 15685553
The route to pathologies in chronic inflammatory diseases characterized by T helper type 2 immune cells. K Jovanovic, M Siebeck, R Gropp. Clin Exp Immunol, 2014 Jul 02; 178(2). PMID: 24981014 Free PMC article. Review.
Foxp3+ regulatory T cells maintain immune homeostasis in the skin. Jan C Dudda, Nikole Perdue, Eva Bachtanian, Daniel J Campbell. J Exp Med, 2008 Jun 25; 205(7). PMID: 18573908 Free PMC article.
The alarmin IL-33 promotes regulatory T-cell function in the intestine. Chris Schiering, Thomas Krausgruber, +13 authors, Fiona Powrie. less Nature, 2014 Jul 22; 513(7519). PMID: 25043027 Free PMC article. Highly Cited.
Role of tissue protection in lethal respiratory viral-bacterial coinfection. Amanda M Jamieson, Lesley Pasman, +4 authors, Ruslan Medzhitov. less Science, 2013 Apr 27; 340(6137). PMID: 23618765 Free PMC article. Highly Cited.
Cancer immunotherapy via dendritic cells. Karolina Palucka, Jacques Banchereau. Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871 Free PMC article. Highly Cited. Review.
Differential roles of macrophages in diverse phases of skin repair. Tina Lucas, Ari Waisman, +5 authors, Sabine A Eming. less J Immunol, 2010 Feb 24; 184(7). PMID: 20176743 Highly Cited.
IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer. R S Herbst, E S Kim, P M Harari. Expert Opin Biol Ther, 2001 Dec 01; 1(4). PMID: 11727507 Review.
EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate. Kathryn A Stern, Trenton L Place, Nancy L Lill. Biochem J, 2007 Nov 30; 410(3). PMID: 18045238 Free PMC article.
Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. B Boris Vargaftig, Monique Singer. Am J Physiol Lung Cell Mol Physiol, 2003 Jun 10; 285(4). PMID: 12794006
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. A Desmoulière, A Geinoz, F Gabbiani, G Gabbiani. J Cell Biol, 1993 Jul 01; 122(1). PMID: 8314838 Free PMC article. Highly Cited.
Amphiregulin, a TH2 cytokine enhancing resistance to nematodes. Dietmar M Zaiss, Li Yang, +3 authors, Tim R Mosmann. less Science, 2006 Dec 16; 314(5806). PMID: 17170297
ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion. Nathalie Bles, Larissa Di Pietrantonio, Jean-Marie Boeynaems, Didier Communi. Blood, 2010 Jul 24; 116(17). PMID: 20651071
Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue. Lejla Pasic, T S Karin Eisinger-Mathason, +4 authors, Deborah A Lannigan. less Genes Dev, 2011 Aug 11; 25(15). PMID: 21828273 Free PMC article.
A special population of regulatory T cells potentiates muscle repair. Dalia Burzyn, Wilson Kuswanto, +8 authors, Diane Mathis. less Cell, 2013 Dec 10; 155(6). PMID: 24315098 Free PMC article. Highly Cited.
Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. Kjetil Ask, Philippe Bonniaud, +6 authors, Martin Kolb. less Int J Biochem Cell Biol, 2007 Oct 13; 40(3). PMID: 17931953 Free PMC article.
Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites. Nirav Patel, Timothy Kreider, Joseph F Urban, William C Gause. Int J Parasitol, 2008 Sep 23; 39(1). PMID: 18804113 Free PMC article. Review.
Susceptibility and immunity to helminth parasites. Rick M Maizels, James P Hewitson, Katherine A Smith. Curr Opin Immunol, 2012 Jul 17; 24(4). PMID: 22795966 Free PMC article. Highly Cited. Review.
EGFR antagonists in cancer treatment. Fortunato Ciardiello, Giampaolo Tortora. N Engl J Med, 2008 Mar 14; 358(11). PMID: 18337605 Highly Cited. Review.
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. Mallika Kaviratne, Matthias Hesse, +6 authors, Thomas A Wynn. less J Immunol, 2004 Sep 10; 173(6). PMID: 15356151 Highly Cited.
Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Devin T Worster, Tobias Schmelzle, +5 authors, John G Albeck. less Sci Signal, 2012 Mar 08; 5(214). PMID: 22394561 Free PMC article.
Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis. Na Liu, Jian-Kan Guo, +7 authors, Shougang Zhuang. less J Am Soc Nephrol, 2012 Mar 01; 23(5). PMID: 22362908 Free PMC article.
Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy. Francesca Mascia, Gary Lam, +4 authors, Stuart H Yuspa. less Sci Transl Med, 2013 Aug 24; 5(199). PMID: 23966299 Free PMC article.
Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. David S Schneider, Janelle S Ayres. Nat Rev Immunol, 2008 Oct 18; 8(11). PMID: 18927577 Free PMC article. Highly Cited. Review.
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Stefan Fichtner-Feigl, Warren Strober, +2 authors, Koji Kawakami, Raj K Puri, Atsushi Kitani. less Nat Med, 2005 Dec 06; 12(1). PMID: 16327802 Highly Cited.
Heparan sulfate: a ubiquitous glycosaminoglycan with multiple roles in immunity. David Anak Simon Davis, Christopher R Parish. Front Immunol, 2014 Jan 07; 4. PMID: 24391644 Free PMC article.
Efficient Treg depletion induces T-cell infiltration and rejection of large tumors. Xingrui Li, Efterpi Kostareli, +2 authors, Janine Suffner, Natalio Garbi, Günter J Hämmerling. less Eur J Immunol, 2010 Nov 13; 40(12). PMID: 21072887
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. S Traverse, N Gomez, +2 authors, H Paterson, C Marshall, P Cohen. less Biochem J, 1992 Dec 01; 288 ( Pt 2). PMID: 1334404 Free PMC article. Highly Cited.
The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types. C Christian Johansson, Arne Yndestad, +3 authors, Kjetil Taskén. less Endocrinology, 2004 Jul 31; 145(11). PMID: 15284208
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. M G Chiaramonte, D D Donaldson, A W Cheever, T A Wynn. J Clin Invest, 1999 Sep 24; 104(6). PMID: 10491413 Free PMC article. Highly Cited.
Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells. H Kimura, D Schubert. J Cell Biol, 1992 Feb 01; 116(3). PMID: 1530950 Free PMC article.
Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor. G R Johnson, L Wong. J Biol Chem, 1994 Oct 28; 269(43). PMID: 7929459
Emerging perspectives in epidermal growth factor receptor targeting in head and neck cancer. Seungwon Kim, Jennifer R Grandis, +2 authors, Alessandra Rinaldo, Robert P Takes, Alfio Ferlito. less Head Neck, 2008 Apr 03; 30(5). PMID: 18383530 Review.
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths. William C Gause, Thomas A Wynn, Judith E Allen. Nat Rev Immunol, 2013 Jul 06; 13(8). PMID: 23827958 Free PMC article. Highly Cited. Review.
Cutaneous manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. M Halabi-Tawil, F M Ruemmele, +7 authors, C Bodemer. less Br J Dermatol, 2008 Sep 18; 160(3). PMID: 18795917
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). C G Lee, R J Homer, +9 authors, J A Elias. less J Exp Med, 2001 Sep 19; 194(6). PMID: 11560996 Free PMC article. Highly Cited.
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. R P Sutmuller, L M van Duivenvoorde, +6 authors, C J Melief. less J Exp Med, 2001 Sep 19; 194(6). PMID: 11560997 Free PMC article. Highly Cited.
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. Ki Young Chung, Jinru Shia, +11 authors, Leonard B Saltz. less J Clin Oncol, 2005 Jan 29; 23(9). PMID: 15677699 Highly Cited.
Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Laura J Cliffe, Neil E Humphreys, +3 authors, Richard K Grencis. less Science, 2005 Jun 04; 308(5727). PMID: 15933199 Highly Cited.
The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection. Laura J Cliffe, Richard K Grencis. Adv Parasitol, 2004 Oct 27; 57. PMID: 15504540 Review.
Oscillatory dynamics of the extracellular signal-regulated kinase pathway. Harish Shankaran, H Steven Wiley. Curr Opin Genet Dev, 2010 Sep 03; 20(6). PMID: 20810275 Review.
Differential effects of amphiregulin and TGF-alpha on the morphology of MDCK cells. Eunkyung Chung, Ramona Graves-Deal, Jeffrey L Franklin, Robert J Coffey. Exp Cell Res, 2005 Jun 28; 309(1). PMID: 15979068
Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing. Hirotaka Suga, Robert C Rennert, +6 authors, Geoffrey C Gurtner. less Stem Cells, 2014 Jan 22; 32(5). PMID: 24446236 Free PMC article.
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. N C Luetteke, T H Qiu, +4 authors, D C Lee. less Development, 1999 May 20; 126(12). PMID: 10331984 Highly Cited.
Efficient colonic mucosal wound repair requires Trem2 signaling. Hiroshi Seno, Hiroyuki Miyoshi, +3 authors, Thaddeus S Stappenbeck. less Proc Natl Acad Sci U S A, 2008 Dec 26; 106(1). PMID: 19109436 Free PMC article.
Mast cell mediators in tolerance. Victor C de Vries, Randolph J Noelle. Curr Opin Immunol, 2010 Oct 05; 22(5). PMID: 20884193 Free PMC article. Review.
Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. D A Vardy, C Kari, +4 authors, U Rodeck. less J Cell Physiol, 1995 May 01; 163(2). PMID: 7706370
Binding specificities and affinities of egf domains for ErbB receptors. J T Jones, R W Akita, M X Sliwkowski. FEBS Lett, 1999 Apr 24; 447(2-3). PMID: 10214951
Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells. Dennis B Leveson-Gower, Emanuela I Sega, +5 authors, Robert S Negrin. less Blood, 2013 Sep 14; 122(22). PMID: 24030387 Free PMC article.
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. Barbara Burtness, Meredith A Goldwasser, +3 authors, Eastern Cooperative Oncology Group. less J Clin Oncol, 2005 Nov 30; 23(34). PMID: 16314626 Highly Cited.
Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. M Shoyab, V L McDonald, J G Bradley, G J Todaro. Proc Natl Acad Sci U S A, 1988 Sep 01; 85(17). PMID: 3413110 Free PMC article. Highly Cited.
Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens. Judith E Allen, Thomas A Wynn. PLoS Pathog, 2011 May 19; 7(5). PMID: 21589896 Free PMC article. Highly Cited.
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Ya-Jen Chang, Hye Young Kim, +5 authors, Dale T Umetsu. less Nat Immunol, 2011 May 31; 12(7). PMID: 21623379 Free PMC article. Highly Cited.
A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. P W Cook, P A Mattox, +5 authors, G D Shipley. less Mol Cell Biol, 1991 May 01; 11(5). PMID: 2017164 Free PMC article.
Dendritic cells, inflammation, and breast cancer. Karolina Palucka, Lisa M Coussens, Joyce O'Shaughnessy. Cancer J, 2013 Nov 26; 19(6). PMID: 24270350 Free PMC article. Review.
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Tamar McHedlidze, Maximilian Waldner, +8 authors, Stefan Wirtz. less Immunity, 2013 Aug 21; 39(2). PMID: 23954132 Free PMC article. Highly Cited.
Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nora Branzk, Aleksandra Lubojemska, +4 authors, Venizelos Papayannopoulos. less Nat Immunol, 2014 Sep 15; 15(11). PMID: 25217981 Free PMC article. Highly Cited.
Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells. Karin D Rodland, Nikki Bollinger, +4 authors, H Steven Wiley. less J Biol Chem, 2008 Sep 11; 283(46). PMID: 18782770 Free PMC article.
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Fei Chen, Zhugong Liu, +7 authors, William C Gause. less Nat Med, 2012 Jan 17; 18(2). PMID: 22245779 Free PMC article. Highly Cited.
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Laurel A Monticelli, Gregory F Sonnenberg, +15 authors, David Artis. less Nat Immunol, 2011 Sep 29; 12(11). PMID: 21946417 Free PMC article. Highly Cited.
Human basophils express amphiregulin in response to T cell-derived IL-3. Yilin Qi, Darwin J Operario, +4 authors, Tim R Mosmann. less J Allergy Clin Immunol, 2010 Nov 03; 126(6). PMID: 21036386 Free PMC article.
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Dietmar M W Zaiss, Jorg van Loosdregt, +7 authors, Alice J A M Sijts. less Immunity, 2013 Jan 22; 38(2). PMID: 23333074 Free PMC article. Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
Protective immune mechanisms in helminth infection. Robert M Anthony, Laura I Rutitzky, +2 authors, Joseph F Urban, Miguel J Stadecker, William C Gause. less Nat Rev Immunol, 2007 Nov 17; 7(12). PMID: 18007680 Free PMC article. Highly Cited. Review.
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. John G Albeck, Gordon B Mills, Joan S Brugge. Mol Cell, 2012 Dec 12; 49(2). PMID: 23219535 Free PMC article. Highly Cited.
Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. Q Hamid, M Boguniewicz, D Y Leung. J Clin Invest, 1994 Aug 01; 94(2). PMID: 8040343 Free PMC article. Highly Cited.

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Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease. G Goel, A J M Daveson, +8 authors, R P Anderson. less Clin Exp Immunol, 2019 Sep 11; 199(1). PMID: 31505020 Free PMC article.
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ILC2s in infectious diseases and organ-specific fibrosis. Markus Kindermann, Lisa Knipfer, Imke Atreya, Stefan Wirtz. Semin Immunopathol, 2018 Apr 07; 40(4). PMID: 29623414 Review.
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AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer. Shawn P Kubli, Christian Bassi, +30 authors, Chiara Gorrini. less Proc Natl Acad Sci U S A, 2019 Feb 09; 116(9). PMID: 30733286 Free PMC article.
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Innate immune cell-epithelial crosstalk during wound repair. Jennifer C Brazil, Miguel Quiros, Asma Nusrat, Charles A Parkos. J Clin Invest, 2019 Jul 23; 129(8). PMID: 31329162 Free PMC article. Highly Cited. Review.
Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG. Yaojia X Yaojia Cheng, Qiuping Lu, +5 authors, Chen Liu. less Int J Mol Med, 2020 Mar 04; 45(4). PMID: 32124941 Free PMC article.
Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development. Lucas F Loffredo, Mackenzie E Coden, +9 authors, Sergejs Berdnikovs. less Sci Rep, 2020 Mar 12; 10(1). PMID: 32157178 Free PMC article.
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Emerging Roles of Interleukin-33-responsive Kidney Group 2 Innate Lymphoid Cells in Acute Kidney Injury. Wei-Yu Chen, Lung-Chih Li, +2 authors, Yi-Hsiu Wu, Jenq-Lin Yang, Hong-Tai Tzeng. less Int J Mol Sci, 2020 Feb 28; 21(4). PMID: 32102434 Free PMC article. Review.
Unravelling the networks dictating host resistance versus tolerance during pulmonary infections. Isabelle Meunier, Eva Kaufmann, Jeffrey Downey, Maziar Divangahi. Cell Tissue Res, 2017 Feb 09; 367(3). PMID: 28168323 Free PMC article. Review.
Immune Cell-Epithelial/Mesenchymal Interaction Contributing to Allergic Airway Inflammation Associated Pathology. Kiyoshi Hirahara, Kenta Shinoda, +5 authors, Toshinori Nakayama. less Front Immunol, 2019 Apr 12; 10. PMID: 30972065 Free PMC article. Review.
The Role of T Cells in Herpes Stromal Keratitis. Naveen K Rajasagi, Barry T Rouse. Front Immunol, 2019 Apr 04; 10. PMID: 30941142 Free PMC article. Review.
Deciphering the Roles of Innate Lymphoid Cells in Cancer. Melanie Bruchard, Francois Ghiringhelli. Front Immunol, 2019 Apr 27; 10. PMID: 31024531 Free PMC article. Highly Cited. Review.
IL-33 Mediated Inflammation in Chronic Respiratory Diseases-Understanding the Role of the Member of IL-1 Superfamily. Agata Gabryelska, Piotr Kuna, +2 authors, Adam Antczak, Piotr Białasiewicz, Michał Panek. less Front Immunol, 2019 May 07; 10. PMID: 31057533 Free PMC article. Review.
An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease. Liang Shao, Shan Pan, +9 authors, Albert K W Lie. less Front Immunol, 2019 Jun 28; 10. PMID: 31244831 Free PMC article. Review.
Reparative T lymphocytes in organ injury. Franco R D'Alessio, Johanna T Kurzhagen, Hamid Rabb. J Clin Invest, 2019 Jul 02; 129(7). PMID: 31259743 Free PMC article. Review.
Metabolites released from apoptotic cells act as tissue messengers. Christopher B Medina, Parul Mehrotra, +9 authors, Kodi S Ravichandran. less Nature, 2020 Apr 03; 580(7801). PMID: 32238926 Free PMC article.
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. Dongsheng Shang, Danlin Sun, +5 authors, Zhigang Tu. less Aging Cell, 2020 Apr 24; 19(5). PMID: 32323422 Free PMC article.
Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair. Ian C Boothby, Jarish N Cohen, Michael D Rosenblum. Sci Immunol, 2020 May 03; 5(47). PMID: 32358172 Free PMC article. Review.
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Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma. Yu-Wen Huang, Chih-Yang Lin, +9 authors, Chih-Hsin Tang. less Aging (Albany NY), 2020 May 20; 12(10). PMID: 32428872 Free PMC article.
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The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing. Kavya L Singampalli, Swathi Balaji, +6 authors, Sundeep G Keswani. less Front Cell Dev Biol, 2020 Aug 28; 8. PMID: 32850791 Free PMC article. Review.
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Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity. Linh T Bui, Nichelle I Winters, +19 authors, Human Cell Atlas Lung Biological Network. less bioRxiv, 2020 Oct 28;. PMID: 33106805 Free PMC article.
The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation. Yuichi Akama, Naoko Satoh-Takayama, +5 authors, Motomu Shimaoka. less Diagnostics (Basel), 2020 Oct 16; 10(10). PMID: 33053762 Free PMC article. Review.
Abundance of Non-Polarized Lung Macrophages with Poor Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). Kentaro Akata, Kei Yamasaki, +8 authors, Stephan F van Eeden. less Biomedicines, 2020 Oct 15; 8(10). PMID: 33050042 Free PMC article.
The transition of M-CSF-derived human macrophages to a growth-promoting phenotype. Kajal Hamidzadeh, Ashton T Belew, Najib M El-Sayed, David M Mosser. Blood Adv, 2020 Nov 10; 4(21). PMID: 33166408 Free PMC article.
Neural Regulation of Interactions Between Group 2 Innate Lymphoid Cells and Pulmonary Immune Cells. Weiwei Chen, Qiang Shu, Jie Fan. Front Immunol, 2020 Nov 17; 11. PMID: 33193374 Free PMC article. Review.
Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma. Mahmood Yaseen Hachim, Noha Mousaad Elemam, +9 authors, Rifat Hamoudi. less Front Med (Lausanne), 2020 Nov 17; 7. PMID: 33195308 Free PMC article.
Whole Transcriptome Analysis of Myeloid Dendritic Cells Reveals Distinct Genetic Regulation in Patients with Allergies. Kijeong Lee, Mi-Ryung Han, +2 authors, Ji Woo Yeon, Byoungjae Kim, Tae Hoon Kim. less Int J Mol Sci, 2020 Nov 20; 21(22). PMID: 33207814 Free PMC article.
The Evaluation of AREG, MMP-2, CHI3L1, GFAP, and OPN Serum Combined Value in Astrocytic Glioma Patients' Diagnosis and Prognosis. Rūta Urbanavičiūtė, Kęstutis Skauminas, Daina Skiriutė. Brain Sci, 2020 Nov 25; 10(11). PMID: 33227903 Free PMC article.
Group 2 Innate Lymphoid Cells: A Double-Edged Sword in Cancer? Enrico Maggi, Irene Veneziani, +2 authors, Lorenzo Moretta, Lorenzo Cosmi, Francesco Annunziato. less Cancers (Basel), 2020 Nov 26; 12(11). PMID: 33233582 Free PMC article. Review.
Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica. Chunsheng Yang, Yang Yang, +4 authors, Guoqiang Chang. less Int J Mol Med, 2019 Jan 11; 43(3). PMID: 30628649 Free PMC article.
Biomaterials: Foreign Bodies or Tuners for the Immune Response? Erminia Mariani, Gina Lisignoli, Rosa Maria Borzì, Lia Pulsatelli. Int J Mol Sci, 2019 Feb 06; 20(3). PMID: 30717232 Free PMC article. Highly Cited. Review.
Type 2 Innate Lymphoid Cells in Liver and Gut: From Current Knowledge to Future Perspectives. Aaron Ochel, Gisa Tiegs, Katrin Neumann. Int J Mol Sci, 2019 Apr 20; 20(8). PMID: 30999584 Free PMC article. Review.
Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit. Rama Shankar, Mara L Leimanis, +9 authors, Surender Rajasekaran. less EBioMedicine, 2020 Nov 29; 62. PMID: 33248372 Free PMC article.
Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis. Samantha M Golomb, Ian H Guldner, +7 authors, Siyuan Zhang. less Cell Rep, 2020 Dec 03; 33(9). PMID: 33264626 Free PMC article.
Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice. Shanshan Tang, Mingfeng Zhang, +7 authors, Defu Zeng. less Proc Natl Acad Sci U S A, 2020 Nov 25; 117(49). PMID: 33229527 Free PMC article.
Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn. Dan Yan, Fei Yu, +8 authors, Chunyi Shao. less Invest Ophthalmol Vis Sci, 2020 Dec 17; 61(14). PMID: 33326018 Free PMC article.
Function of innate lymphoid cells in the immune-related disorders. Tanja Dzopalić, Biljana Božić-Nedeljković, Vladimir Jurišić. Hum Cell, 2019 May 13; 32(3). PMID: 31079327 Review.
Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. Allen F Ryan, Chanond A Nasamran, +4 authors, Arwa Kurabi. less Front Genet, 2020 May 01; 11. PMID: 32351546 Free PMC article.
In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals. Seung Seob Son, Soohyun Hwang, +7 authors, Eun Young Lee. less Sci Rep, 2021 Jan 28; 11(1). PMID: 33500443 Free PMC article.
Amphiregulin Regulates Melanocytic Senescence. Michaela Pommer, Silke Kuphal, Anja K Bosserhoff. Cells, 2021 Feb 11; 10(2). PMID: 33562468 Free PMC article.
Macrophages in Lung Injury, Repair, and Fibrosis. Peiyong Cheng, Shuangyan Li, Huaiyong Chen. Cells, 2021 Mar 07; 10(2). PMID: 33670759 Free PMC article. Review.
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease. Caspar Schiffers, Cheryl van de Wetering, +8 authors, Albert van der Vliet. less JCI Insight, 2020 Dec 11; 6(2). PMID: 33301419 Free PMC article.
Untangling Local Pro-Inflammatory, Reparative, and Regulatory Damage-Associated Molecular-Patterns (DAMPs) Pathways to Improve Transplant Outcomes. Gaelen K Dwyer, Hēth R Turnquist. Front Immunol, 2021 Mar 13; 12. PMID: 33708206 Free PMC article. Review.
Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort. Isabel Drake, George Hindy, +4 authors, Marju Orho-Melander. less Sci Rep, 2021 Mar 26; 11(1). PMID: 33762603 Free PMC article.
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy. Vincenzo Salemme, Giorgia Centonze, +2 authors, Federica Cavallo, Paola Defilippi, Laura Conti. less Front Oncol, 2021 Mar 30; 11. PMID: 33777750 Free PMC article. Review.
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract. Tim Flerlage, David F Boyd, +2 authors, Victoria Meliopoulos, Paul G Thomas, Stacey Schultz-Cherry. less Nat Rev Microbiol, 2021 Apr 08; 19(7). PMID: 33824495 Free PMC article. Review.
The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration. Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic. Int J Mol Sci, 2021 Apr 04; 22(5). PMID: 33804369 Free PMC article. Review.
Insights Into Human Intrahepatic NK Cell Function From Single Cell RNA Sequencing Datasets. Gráinne Jameson, Mark W Robinson. Front Immunol, 2021 Apr 09; 12. PMID: 33828559 Free PMC article. Review.
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity. Egle Kvedaraite, Laura Hertwig, +22 authors, Karolinska KI/K COVID-19 Study Group. less Proc Natl Acad Sci U S A, 2021 Jan 23; 118(6). PMID: 33479167 Free PMC article.
T resident helper cells promote humoral responses in the lung. Nivedya Swarnalekha, David Schreiner, +7 authors, Carolyn G King. less Sci Immunol, 2021 Jan 10; 6(55). PMID: 33419790 Free PMC article.
IL-33-mediated Eosinophilia Protects against Acute Lung Injury. Paulette A Krishack, Maile K Hollinger, +5 authors, Philip A Verhoef. less Am J Respir Cell Mol Biol, 2021 Feb 12; 64(5). PMID: 33571420 Free PMC article.
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Hani Harb, Mehdi Benamar, +30 authors, Talal A Chatila. less Immunity, 2021 Apr 30; 54(6). PMID: 33915108 Free PMC article.
Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury. Ryota Sakai, Minako Ito, +9 authors, Akihiko Yoshimura. less Cell Mol Immunol, 2020 Sep 13; 18(5). PMID: 32917984 Free PMC article.
Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes. Joshua R Cox, Sheena M Cruickshank, Amy E Saunders. Front Immunol, 2021 May 04; 12. PMID: 33936115 Free PMC article. Review.
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions. Giuseppe Ercolano, Alejandra Gomez-Cadena, +14 authors, Camilla Jandus. less Nat Commun, 2021 May 07; 12(1). PMID: 33953160 Free PMC article.
Role of ILC2 in Viral-Induced Lung Pathogenesis. Wendy Fonseca, Nicholas W Lukacs, Srikanth Elesela, Carrie-Anne Malinczak. Front Immunol, 2021 May 07; 12. PMID: 33953732 Free PMC article. Review.
Critical role of interferons in gastrointestinal injury repair. Constance McElrath, Vanessa Espinosa, +15 authors, Sergei V Kotenko. less Nat Commun, 2021 May 13; 12(1). PMID: 33976143 Free PMC article.
Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication. Liangxing Guo, Zhaokun Mu, +7 authors, Mengyun Li. less Sci Rep, 2021 May 15; 11(1). PMID: 33986327 Free PMC article.
Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing. Chen Hu, Chenyu Chu, +7 authors, Yi Man. less Sci Adv, 2021 May 28; 7(22). PMID: 34039601 Free PMC article. Review.
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma. Nicolas Jacquelot, Cyril Seillet, +34 authors, Gabrielle T Belz. less Nat Immunol, 2021 Jun 09; 22(7). PMID: 34099918 Free PMC article.
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53. Moshit Lindzen, Soma Ghosh, +13 authors, Yosef Yarden. less Oncogene, 2021 May 05; 40(21). PMID: 33941851 Free PMC article.
Sex hormone regulation of innate lymphoid cells. Eve Blanquart, Sophie Laffont, Jean-Charles Guéry. Biomed J, 2021 Apr 24; 44(2). PMID: 33888441 Free PMC article. Review.
Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment. Ran Ran, Haoqing Yang, +3 authors, Yangyang Cao, Wanhao Yan, Luyuan Jin, Ying Zheng. less BMC Oral Health, 2021 Jun 23; 21(1). PMID: 34154572 Free PMC article.
Acute Effects on the Human Peripheral Blood Transcriptome of Decompression Sickness Secondary to Scuba Diving. Kurt Magri, Ingrid Eftedal, +4 authors, Nikolai Paul Pace. less Front Physiol, 2021 Jun 29; 12. PMID: 34177613 Free PMC article.
Identification of Monocytes Associated with Severe COVID-19 in the PBMCs of Severely Infected patients Through Single-Cell Transcriptome Sequencing. Yan Zhang, Shuting Wang, +9 authors, Lanjuan Li. less Engineering (Beijing), 2021 Jun 22;. PMID: 34150352 Free PMC article.
The Janus Face of IL-33 Signaling in Tumor Development and Immune Escape. Mi-Ran Choi, Jeffrey A Sosman, Bin Zhang. Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34209038 Free PMC article. Review.
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity. Linh T Bui, Nichelle I Winters, +19 authors, Human Cell Atlas Lung Biological Network. less Nat Commun, 2021 Jul 16; 12(1). PMID: 34262047 Free PMC article.
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Zheng Fu, Joseph W Dean, +6 authors, Liang Zhou. less Nat Commun, 2021 Jul 24; 12(1). PMID: 34294718 Free PMC article.
Nanoencapsulated Doxorubicin Prevents Mucositis Development in Mice. Cristiane M Pinto, Laila S Horta, +7 authors, Gisele A C Goulart. less Pharmaceutics, 2021 Aug 11; 13(7). PMID: 34371713 Free PMC article.
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy. Laura A Huppert, Michael D Green, +4 authors, James C Lee. less Cell Mol Immunol, 2021 Aug 22; 19(1). PMID: 34417572 Free PMC article. Review.
Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia. Alex R Schuurman, Tom DY Reijnders, +9 authors, Tom van der Poll. less Elife, 2021 Aug 24; 10. PMID: 34424199 Free PMC article.
Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection. N Bhaskaran, E Schneider, +9 authors, P Pandiyan. less Nat Commun, 2021 Aug 28; 12(1). PMID: 34446704 Free PMC article.
Serum Amphiregulin and Heparin-Binding Epidermal Growth Factor as Biomarkers in Patients with Idiopathic Inflammatory Myopathy. Norio Hanata, Yasuo Nagafuchi, +5 authors, Keishi Fujio. less J Clin Med, 2021 Aug 28; 10(16). PMID: 34442026 Free PMC article.
Interactions between islets and regulatory immune cells in health and type 1 diabetes. Matthew A Budd, Mahdis Monajemi, +3 authors, Megan K Levings. less Diabetologia, 2021 Sep 23; 64(11). PMID: 34550422 Review.
C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived Macrophages. Jacquelyn C Serfecz, Afsoon Saadin, +4 authors, Ricardo A Feldman. less Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34576075 Free PMC article.
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease. Sheila K Pierson, Sushila Shenoy, +22 authors, David C Fajgenbaum. less Blood Adv, 2021 Aug 27; 5(17). PMID: 34438448 Free PMC article.
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells. Florian Klemm, Roeltje R Maas, +11 authors, Johanna A Joyce. less Cell, 2020 May 30; 181(7). PMID: 32470396 Free PMC article.
Interleukin-2 and regulatory T cells in rheumatic diseases. Antonios G A Kolios, George C Tsokos, David Klatzmann. Nat Rev Rheumatol, 2021 Nov 04; 17(12). PMID: 34728817 Review.
Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells. Shang Chen, Haoyan Huang, +10 authors, Zongjin Li. less iScience, 2021 Nov 09; 24(11). PMID: 34746706 Free PMC article.
Tissue-Specific Molecular Markers and Heterogeneity in Type 2 Innate Lymphoid Cells. Enrique Olguín-Martínez, Blanca E Ruiz-Medina, Paula Licona-Limón. Front Immunol, 2021 Nov 12; 12. PMID: 34759931 Free PMC article. Review.
Type 2 immunity in intestinal homeostasis and inflammatory bowel disease. Xinxin Luo, Eduardo J Villablanca. Biochem Soc Trans, 2021 Sep 29; 49(5). PMID: 34581755 Free PMC article. Review.
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice. Ming Zhao, Yingyao Quan, +10 authors, Chu-Xia Deng. less Int J Biol Sci, 2021 Nov 23; 17(15). PMID: 34803491 Free PMC article.
Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin. Salvatore J Coniglio, Jeffrey E Segall. PLoS One, 2021 Nov 30; 16(11). PMID: 34843542 Free PMC article.
Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling. Joel Zindel, Jonas Mittner, +13 authors, Daniel Candinas. less Nat Commun, 2021 Dec 18; 12(1). PMID: 34916513 Free PMC article.
Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease. Satoshi Kubo, Jill M Fritz, +31 authors, Michael J Lenardo. less Nat Immunol, 2021 Dec 24; 23(1). PMID: 34937930
Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge. Christopher M Dustin, Aida Habibovic, +8 authors, Albert van der Vliet. less J Immunol, 2021 Jun 06; 206(12). PMID: 34088769 Free PMC article.
Disease Tolerance during Viral-Bacterial Co-Infections. Tarani Kanta Barman, Dennis W Metzger. Viruses, 2021 Dec 29; 13(12). PMID: 34960631 Free PMC article. Review.
IL-33, an Alarmin of the IL-1 Family Involved in Allergic and Non Allergic Inflammation: Focus on the Mechanisms of Regulation of Its Activity. Corinne Cayrol. Cells, 2022 Jan 12; 11(1). PMID: 35011670 Free PMC article. Review.
Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD. Danny W Bruce, Oleg Kolupaev, +5 authors, Jonathan S Serody. less Blood Adv, 2021 Oct 08; 5(22). PMID: 34619767 Free PMC article.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Avraham Unterman, Tomokazu S Sumida, +46 authors, Charles S Dela Cruz. less Nat Commun, 2022 Jan 23; 13(1). PMID: 35064122 Free PMC article.
Cytokine Elevation in Severe COVID-19 From Longitudinal Proteomics Analysis: Comparison With Sepsis. Takeshi Ebihara, Hisatake Matsumoto, +9 authors, Hiroshi Ogura. less Front Immunol, 2022 Feb 01; 12. PMID: 35095877 Free PMC article.
Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair. Kelly Walton, Kirsti Walker, +19 authors, Brian C Betts. less Am J Transplant, 2021 Oct 21; 22(3). PMID: 34668635 Free PMC article.
Involvement of IL-33 in the Pathophysiology of Systemic Lupus Erythematosus: Review. Julie Sarrand, Muhammad Soyfoo. Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328556 Free PMC article. Review.
The Discovery, Validation, and Function of Hypoxia-Related Gene Biomarkers for Obstructive Sleep Apnea. Xiaofeng Wu, Zhou Pan, +4 authors, Ke Hu. less Front Med (Lausanne), 2022 Apr 05; 9. PMID: 35372438 Free PMC article.
Tissue remodeling by an opportunistic pathogen triggers allergic inflammation. Karen Agaronyan, Lokesh Sharma, +8 authors, Ruslan Medzhitov. less Immunity, 2022 Apr 29; 55(5). PMID: 35483356 Free PMC article.
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity. Jihye Han, Qingqing Wan, +5 authors, Yun-Cai Liu. less J Exp Med, 2022 May 10; 219(6). PMID: 35532553 Free PMC article.

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