. 2015 Feb; 42(2):216-226.
doi: 10.1016/j.immuni.2015.01.020.

Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair

Dietmar M W Zaiss 1 William C Gause 2 Lisa C Osborne 3 David Artis 4 
  • PMID: 25692699
  •     116 References
  •     192 citations


Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms, allergens, and infectious agents, and play critical roles in resistance and tolerance associated with infection, wound healing, tissue repair, and tumor development. Emerging data suggest that in addition to characteristic type 2-associated cytokines, the epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of type 2-mediated resistance and tolerance. Notably, numerous studies demonstrate that in addition to the established role of epithelial- and mesenchymal-derived AREG, multiple leukocyte populations including mast cells, basophils, group 2 innate lymphoid cells (ILC2s), and a subset of tissue-resident regulatory CD4(+) T cells can express AREG. In this review, we discuss recent advances in our understanding of the AREG-EGF receptor pathway and its involvement in infection and inflammation and propose a model for the function of this pathway in the context of resistance and tissue tolerance.

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Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
Dietmar M W Zaiss, Jorg van Loosdregt, +7 authors, Alice J A M Sijts.
Immunity, 2013 Jan 22; 38(2). PMID: 23333074    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Protective immune mechanisms in helminth infection.
Robert M Anthony, Laura I Rutitzky, +2 authors, William C Gause.
Nat Rev Immunol, 2007 Nov 17; 7(12). PMID: 18007680    Free PMC article.
Highly Cited. Review.
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.
John G Albeck, Gordon B Mills, Joan S Brugge.
Mol Cell, 2012 Dec 12; 49(2). PMID: 23219535    Free PMC article.
Highly Cited.
Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.
Q Hamid, M Boguniewicz, D Y Leung.
J Clin Invest, 1994 Aug 01; 94(2). PMID: 8040343    Free PMC article.
Highly Cited.
Angiogenic factors and inflammation in steroid-refractory acute graft-vs-host disease.
Shernan G Holtan, Mukta Arora.
Transl Res, 2015 Jun 29; 167(1). PMID: 26117290    Free PMC article.
Mutual Interaction of Basophils and T Cells in Chronic Inflammatory Diseases.
Marika Sarfati, Keiko Wakahara, Laurence Chapuy, Guy Delespesse.
Front Immunol, 2015 Aug 19; 6. PMID: 26284078    Free PMC article.
A Distinct Function of Regulatory T Cells in Tissue Protection.
Nicholas Arpaia, Jesse A Green, +5 authors, Alexander Y Rudensky.
Cell, 2015 Sep 01; 162(5). PMID: 26317471    Free PMC article.
Highly Cited.
Interferon-γ constrains cytokine production of group 2 innate lymphoid cells.
Fujimi Kudo, Masashi Ikutani, +8 authors, Satoshi Takaki.
Immunology, 2015 Oct 02; 147(1). PMID: 26425820    Free PMC article.
Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.
Kazuyo Moro, Hiroki Kabata, +7 authors, Shigeo Koyasu.
Nat Immunol, 2015 Nov 26; 17(1). PMID: 26595888
Highly Cited.
T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R.
Michelle Goritzka, Catherine Pereira, +2 authors, Cecilia Johansson.
Sci Rep, 2015 Dec 22; 5. PMID: 26688048    Free PMC article.
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Maya R Karta, David H Broide, Taylor A Doherty.
Curr Allergy Asthma Rep, 2016 Jan 10; 16(1). PMID: 26746844    Free PMC article.
CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm.
Kiyoshi Hirahara, Toshinori Nakayama.
Int Immunol, 2016 Feb 14; 28(4). PMID: 26874355    Free PMC article.
Highly Cited. Review.
Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.
Colleen M Lau, Simone A Nish, +3 authors, Boris Reizis.
J Exp Med, 2016 Feb 24; 213(3). PMID: 26903243    Free PMC article.
Nasal administration of interleukin-33 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma surrogate.
Shan Shan, Yan Li, +7 authors, Sun Ying.
Immunology, 2016 Apr 02; 148(1). PMID: 27035894    Free PMC article.
Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function.
Katharine Carney, Yu-Mei Ruby Chang, +11 authors, Oliver A Garden.
J Allergy Clin Immunol, 2016 Apr 05; 137(6). PMID: 27040371    Free PMC article.
New insights into basophil heterogeneity.
Landon K Oetjen, Mario Noti, Brian S Kim.
Semin Immunopathol, 2016 May 15; 38(5). PMID: 27178409    Free PMC article.
Possible mechanisms of host resistance to Haemonchus contortus infection in sheep breeds native to the Canary Islands.
Zhengyu Guo, Jorge Francisco González, +6 authors, Robert W Li.
Sci Rep, 2016 May 21; 6. PMID: 27197554    Free PMC article.
Bone Marrow CD11c+ Cell-Derived Amphiregulin Promotes Pulmonary Fibrosis.
Lin Ding, Tianju Liu, +5 authors, Sem H Phan.
J Immunol, 2016 May 22; 197(1). PMID: 27206766    Free PMC article.
Dendritic cells in lung immunopathology.
Peter C Cook, Andrew S MacDonald.
Semin Immunopathol, 2016 Jun 04; 38(4). PMID: 27256370    Free PMC article.
Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients.
Larry Lam, Lydia Chin, +7 authors, Milan Fiala.
FASEB J, 2016 Jul 03; 30(10). PMID: 27368295    Free PMC article.
Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors.
Shernan G Holtan, Nandita Khera, +31 authors, Joseph Pidala.
Blood, 2016 Sep 15; 128(19). PMID: 27625357    Free PMC article.
Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females.
Olivia J Hall, Nathachit Limjunyawong, +5 authors, Sabra L Klein.
PLoS Pathog, 2016 Sep 16; 12(9). PMID: 27631986    Free PMC article.
EGF receptor ligands: recent advances.
Bhuminder Singh, Graham Carpenter, Robert J Coffey.
F1000Res, 2016 Sep 17; 5. PMID: 27635238    Free PMC article.
Interleukin-33 in health and disease.
Foo Yew Liew, Jean-Philippe Girard, Heth Roderick Turnquist.
Nat Rev Immunol, 2016 Oct 27; 16(11). PMID: 27640624
Highly Cited. Review.
EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium.
Wu-Lin Zuo, Jing Yang, +3 authors, Renat Shaykhiev.
Stem Cells, 2016 Oct 07; 35(3). PMID: 27709733    Free PMC article.
Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.
Anna E Kersh, Maiko Sasaki, +2 authors, Brian P Pollack.
Front Pharmacol, 2016 Oct 13; 7. PMID: 27729860    Free PMC article.
DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.
Aida Habibovic, Milena Hristova, +9 authors, Albert van der Vliet.
JCI Insight, 2016 Nov 05; 1(18). PMID: 27812543    Free PMC article.
An Update on Lymphocyte Subtypes in Asthma and Airway Disease.
Daniel M Moldaver, Mark Larché, Christopher D Rudulier.
Chest, 2016 Nov 08; 151(5). PMID: 27818326    Free PMC article.
Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis.
Robert P Schleimer.
Annu Rev Pathol, 2016 Dec 14; 12. PMID: 27959637    Free PMC article.
Highly Cited. Review.
Type I Interferons in Bacterial Infections: A Balancing Act.
Pavel Kovarik, Virginia Castiglia, Masa Ivin, Florian Ebner.
Front Immunol, 2017 Jan 14; 7. PMID: 28082986    Free PMC article.
Highly Cited. Review.
Divide, Conquer, and Sense: CD8+CD28- T Cells in Perspective.
Fernando A Arosa, André J Esgalhado, Carolina A Padrão, Elsa M Cardoso.
Front Immunol, 2017 Jan 18; 7. PMID: 28096804    Free PMC article.
Recent developments in the role of reactive oxygen species in allergic asthma.
Jingjing Qu, Yuanyuan Li, +2 authors, Chengping Hu.
J Thorac Dis, 2017 Feb 17; 9(1). PMID: 28203435    Free PMC article.
Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease.
Danny W Bruce, Heather E Stefanski, +15 authors, Jonathan S Serody.
J Clin Invest, 2017 Apr 05; 127(5). PMID: 28375154    Free PMC article.
Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease.
Dong Hyuk Seo, Xiumei Che, +8 authors, Jae Hee Cheon.
Sci Rep, 2017 Apr 14; 7(1). PMID: 28404987    Free PMC article.
Immune-Mediated Repair: A Matter of Plasticity.
Paôline Laurent, Valérie Jolivel, +4 authors, Thomas Pradeu.
Front Immunol, 2017 May 10; 8. PMID: 28484454    Free PMC article.
New fronts emerge in the influenza cytokine storm.
Xi-Zhi J Guo, Paul G Thomas.
Semin Immunopathol, 2017 May 31; 39(5). PMID: 28555383    Free PMC article.
Highly Cited. Review.
Heart failure: Macrophages take centre stage in the heart-brain-kidney axis.
Herman H W Silljé, Rudolf A de Boer.
Nat Rev Nephrol, 2017 May 31; 13(7). PMID: 28555651
Heterogeneity and Stability in Foxp3+ Regulatory T Cells.
Booki Min.
J Interferon Cytokine Res, 2017 Jul 12; 37(9). PMID: 28696819    Free PMC article.
The Immune System's Contribution to the Clinical Efficacy of EGFR Antagonist Treatment.
Felicity MacDonald, Dietmar M W Zaiss.
Front Pharmacol, 2017 Oct 04; 8. PMID: 28970798    Free PMC article.
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
Carlos M Minutti, Sebastian Drube, +11 authors, Dietmar M Zaiss.
Immunity, 2017 Oct 19; 47(4). PMID: 29045902    Free PMC article.
Preexisting Type 2 Immune Activation Protects against the Development of Sepsis.
Paulette A Krishack, Kanix Wang, +3 authors, Philip A Verhoef.
Am J Respir Cell Mol Biol, 2017 Nov 02; 57(5). PMID: 29090959    Free PMC article.
Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer.
Anna E Kersh, Spencer Ng, +7 authors, Brian P Pollack.
J Clin Pharmacol, 2017 Nov 15; 58(1). PMID: 29136276    Free PMC article.
Editorial: On the Origin and Function of Human NK-Like CD8+ T Cells: Charting New Territories.
Fernando A Arosa.
Front Immunol, 2017 Dec 01; 8. PMID: 29187857    Free PMC article.
Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma.
Yari Ciribilli, Jürgen Borlak.
Oncotarget, 2017 Dec 20; 8(60). PMID: 29254206    Free PMC article.
Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice.
Kristi J Warren, Todd A Wyatt, +7 authors, Jill A Poole.
Safety (Basel), 2018 Feb 02; 3(1). PMID: 29387711    Free PMC article.
Biomarkers in Graft-Versus-Host Disease: from Prediction and Diagnosis to Insights into Complex Graft/Host Interactions.
Fiona C He, Shernan G Holtan.
Curr Hematol Malig Rep, 2018 Feb 02; 13(1). PMID: 29388008
Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression.
Chang-Ching Wei, Yung-Jen Kung, +8 authors, Lei Wan.
EBioMedicine, 2018 Feb 06; 28. PMID: 29398596    Free PMC article.
Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury.
Michael Koeppen, Jae W Lee, +6 authors, Holger K Eltzschig.
Nat Commun, 2018 Feb 28; 9(1). PMID: 29483579    Free PMC article.
The chemokine receptor CCR1 is identified in mast cell-derived exosomes.
Yuting Liang, Longwei Qiao, +5 authors, Li Li.
Am J Transl Res, 2018 Mar 08; 10(2). PMID: 29511430    Free PMC article.
The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology.
Marta Stolarczyk, Bob J Scholte.
Mediators Inflamm, 2018 Mar 16; 2018. PMID: 29540993    Free PMC article.
Biomarkers of chondrosarcoma.
Wonju Jeong, Ha-Jeong Kim.
J Clin Pathol, 2018 Mar 30; 71(7). PMID: 29593061    Free PMC article.
Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.
Andrea J Sant, Katherine A Richards, Jennifer Nayak.
Curr Opin Immunol, 2018 Apr 06; 53. PMID: 29621639    Free PMC article.
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis.
Barbara C Mindt, Jörg H Fritz, Claudia U Duerr.
Front Immunol, 2018 May 16; 9. PMID: 29760695    Free PMC article.
Highly Cited. Review.
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.
Alba Simats, Teresa García-Berrocoso, +6 authors, Joan Montaner.
Sci Rep, 2018 May 23; 8(1). PMID: 29784938    Free PMC article.
Live Vaccination Generates Both Disease Tolerance and Host Resistance During Chronic Pulmonary Infection With Highly Virulent Francisella tularensis SchuS4.
Alicia M Soucy, Gregory J Hurteau, Dennis W Metzger.
J Infect Dis, 2018 Jun 23; 218(11). PMID: 29931113    Free PMC article.
Production of amphiregulin and recovery from influenza is greater in males than females.
Meghan S Vermillion, Rebecca L Ursin, +12 authors, Sabra L Klein.
Biol Sex Differ, 2018 Jul 18; 9(1). PMID: 30012205    Free PMC article.
Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection.
Sapana Kadel, Susan Kovats.
Front Immunol, 2018 Aug 07; 9. PMID: 30079065    Free PMC article.
Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802.
Shernan G Holtan, Todd E DeFor, +34 authors, Margaret L MacMillan.
Blood Adv, 2018 Aug 09; 2(15). PMID: 30087106    Free PMC article.
Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions.
Siva Karthik Varanasi, Naveen K Rajasagi, Ujjaldeep Jaggi, Barry T Rouse.
Mucosal Immunol, 2018 Aug 09; 11(6). PMID: 30087443    Free PMC article.
Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-β and Contribute to Intestinal Homeostasis.
Feidi Chen, Wenjing Yang, +12 authors, Yingzi Cong.
J Immunol, 2018 Sep 02; 201(8). PMID: 30171165    Free PMC article.
Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis.
Siddharth Krishnan, Ian E Prise, +11 authors, Joanne E Konkel.
Proc Natl Acad Sci U S A, 2018 Oct 04; 115(42). PMID: 30279177    Free PMC article.
Comparative mRNA and miRNA transcriptome analysis of a mouse model of IGFIR-driven lung cancer.
Robert A Jones, Sarah E Franks, Roger A Moorehead.
PLoS One, 2018 Nov 10; 13(11). PMID: 30412601    Free PMC article.
Therapeutic administration of IL-10 and amphiregulin alleviates chronic skeletal muscle inflammation and damage induced by infection.
Richard M Jin, Jordan Warunek, Elizabeth A Wohlfert.
Immunohorizons, 2018 Nov 13; 2(5). PMID: 30417170    Free PMC article.
Sortilin as a new membrane inhibitor of EGFR trafficking for overcoming resistance to EGFR inhibitors in non-small cell lung cancer.
Qianping Li, Weijie Ma, Tianhong Li.
J Thorac Dis, 2018 Nov 16; 10(Suppl 26). PMID: 30430029    Free PMC article.
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
Wen Zhang, Qian Li, +3 authors, Yun-Cai Liu.
J Exp Med, 2018 Nov 23; 215(12). PMID: 30463876    Free PMC article.
Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation.
Esmaeil Mortaz, Saeede Amani, +5 authors, Gert Folkerts.
J Immunol Res, 2018 Dec 05; 2018. PMID: 30510964    Free PMC article.
Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and Matrix Metalloproteinases.
Christopher Platen, Stephan Dreschers, +2 authors, Thorsten W Orlikowsky.
Mediators Inflamm, 2018 Dec 14; 2018. PMID: 30524196    Free PMC article.
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Qixia Xu, Qilai Long, +12 authors, Yu Sun.
Aging Cell, 2019 Sep 08; 18(6). PMID: 31493351    Free PMC article.
Tumour Microenvironment and Immune Evasion in EGFR Addicted NSCLC: Hurdles and Possibilities.
Antonio Santaniello, Fabiana Napolitano, +5 authors, Roberto Bianco.
Cancers (Basel), 2019 Sep 27; 11(10). PMID: 31554160    Free PMC article.
Circulating Tumor Biomarkers in Meningiomas Reveal a Signature of Equilibrium Between Tumor Growth and Immune Modulation.
Erdogan Pekcan Erkan, Thomas Ströbel, +4 authors, Okay Saydam.
Front Oncol, 2019 Oct 28; 9. PMID: 31649887    Free PMC article.
T Regulatory Cells and Priming the Suppressive Tumor Microenvironment.
Christina M Paluskievicz, Xuefang Cao, +3 authors, Jonathan S Bromberg.
Front Immunol, 2019 Nov 05; 10. PMID: 31681327    Free PMC article.
Identification and Classification of Differentially Expressed Genes and Network Meta-Analysis Reveals Potential Molecular Signatures Associated With Tuberculosis.
Aftab Alam, Nikhat Imam, +5 authors, Romana Ishrat.
Front Genet, 2019 Nov 22; 10. PMID: 31749827    Free PMC article.
ILC2s: New Actors in Tumor Immunity.
Giuseppe Ercolano, Maryline Falquet, +2 authors, Camilla Jandus.
Front Immunol, 2019 Dec 19; 10. PMID: 31849977    Free PMC article.
Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease.
G Goel, A J M Daveson, +8 authors, R P Anderson.
Clin Exp Immunol, 2019 Sep 11; 199(1). PMID: 31505020    Free PMC article.
Proximal Tubule-Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis.
Eirini Kefaloyianni, Manikanda Raja Keerthi Raja, +4 authors, Andreas Herrlich.
J Am Soc Nephrol, 2019 Nov 05; 30(12). PMID: 31676723    Free PMC article.
Amphiregulin in intestinal acute graft-versus-host disease: a possible diagnostic and prognostic aid.
Khalid Amin, Usman Yaqoob, +13 authors, Shernan G Holtan.
Mod Pathol, 2018 Nov 15; 32(4). PMID: 30425334    Free PMC article.
ILC2 the Rescue?
R Stokes Peebles.
Am J Respir Crit Care Med, 2019 Sep 19; 201(1). PMID: 31532222    Free PMC article.
The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment.
Laura Ducimetière, Marijne Vermeer, Sonia Tugues.
Front Immunol, 2020 Jan 11; 10. PMID: 31921156    Free PMC article.
Trained Innate Immunity and Its Implications for Mucosal Immunity and Inflammation.
George Hajishengallis, Xiaofei Li, Ioannis Mitroulis, Triantafyllos Chavakis.
Adv Exp Med Biol, 2019 Nov 17; 1197. PMID: 31732931    Free PMC article.
Growth Factor Engineering Strategies for Regenerative Medicine Applications.
Xiaochen Ren, Moyuan Zhao, +2 authors, Ziad Julier.
Front Bioeng Biotechnol, 2020 Feb 11; 7. PMID: 32039177    Free PMC article.
Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling.
Seung Won Kim, Soochan Kim, +2 authors, Young Sook Park.
Sci Rep, 2020 Feb 12; 10(1). PMID: 32042047    Free PMC article.
Amphiregulin contributes to airway remodeling in chronic allograft dysfunction after lung transplantation.
Jamie L Todd, Fran L Kelly, +6 authors, Scott M Palmer.
Am J Transplant, 2019 Oct 31; 20(3). PMID: 31665560    Free PMC article.
Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation.
Dimitrios Kouroupis, Annie C Bowles, +5 authors, Diego Correa.
Sci Rep, 2019 Jul 28; 9(1). PMID: 31350444    Free PMC article.
ILC2s in infectious diseases and organ-specific fibrosis.
Markus Kindermann, Lisa Knipfer, Imke Atreya, Stefan Wirtz.
Semin Immunopathol, 2018 Apr 07; 40(4). PMID: 29623414
Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity.
Xi-Zhi J Guo, Pradyot Dash, +10 authors, Paul G Thomas.
Immunity, 2018 Sep 02; 49(3). PMID: 30170813    Free PMC article.
Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.
Ankit Mahendra, Xingyu Yang, +13 authors, Navin Varadarajan.
Arthritis Rheumatol, 2018 Nov 09; 71(4). PMID: 30407753    Free PMC article.
Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils.
Paulette A Krishack, Tyler J Louviere, +6 authors, Philip A Verhoef.
JCI Insight, 2019 Feb 06; 4(6). PMID: 30721149    Free PMC article.
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.
Shawn P Kubli, Christian Bassi, +30 authors, Chiara Gorrini.
Proc Natl Acad Sci U S A, 2019 Feb 09; 116(9). PMID: 30733286    Free PMC article.
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
Toufic Mayassi, Kristin Ladell, +24 authors, Bana Jabri.
Cell, 2019 Feb 12; 176(5). PMID: 30739797    Free PMC article.
A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.
Carlos M Minutti, Rucha V Modak, +14 authors, Dietmar M Zaiss.
Immunity, 2019 Feb 17; 50(3). PMID: 30770250    Free PMC article.
Highly Cited.
Immune- and non-immune-mediated roles of regulatory T-cells during wound healing.
Dietmar M Zaiss, Carlos M Minutti, Johanna A Knipper.
Immunology, 2019 Mar 14; 157(3). PMID: 30866049    Free PMC article.
The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin.
Kiyoshi Hirahara, Ami Aoki, +3 authors, Toshinori Nakayama.
Semin Immunopathol, 2019 Apr 11; 41(3). PMID: 30968186
The balance of power: innate lymphoid cells in tissue inflammation and repair.
Jim G Castellanos, Randy S Longman.
J Clin Invest, 2019 Jun 11; 129(7). PMID: 31180335    Free PMC article.
Innate immune cell-epithelial crosstalk during wound repair.
Jennifer C Brazil, Miguel Quiros, Asma Nusrat, Charles A Parkos.
J Clin Invest, 2019 Jul 23; 129(8). PMID: 31329162    Free PMC article.
Highly Cited. Review.
Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG.
Yaojia X Yaojia Cheng, Qiuping Lu, +5 authors, Chen Liu.
Int J Mol Med, 2020 Mar 04; 45(4). PMID: 32124941    Free PMC article.
Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development.
Lucas F Loffredo, Mackenzie E Coden, +9 authors, Sergejs Berdnikovs.
Sci Rep, 2020 Mar 12; 10(1). PMID: 32157178    Free PMC article.
Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response.
Wei Mu, Jan Provaznik, Thilo Hackert, Margot Zöller.
Cells, 2020 Feb 06; 9(2). PMID: 32013145    Free PMC article.
Emerging Roles of Interleukin-33-responsive Kidney Group 2 Innate Lymphoid Cells in Acute Kidney Injury.
Wei-Yu Chen, Lung-Chih Li, +2 authors, Hong-Tai Tzeng.
Int J Mol Sci, 2020 Feb 28; 21(4). PMID: 32102434    Free PMC article.
Unravelling the networks dictating host resistance versus tolerance during pulmonary infections.
Isabelle Meunier, Eva Kaufmann, Jeffrey Downey, Maziar Divangahi.
Cell Tissue Res, 2017 Feb 09; 367(3). PMID: 28168323    Free PMC article.
Immune Cell-Epithelial/Mesenchymal Interaction Contributing to Allergic Airway Inflammation Associated Pathology.
Kiyoshi Hirahara, Kenta Shinoda, +5 authors, Toshinori Nakayama.
Front Immunol, 2019 Apr 12; 10. PMID: 30972065    Free PMC article.
The Role of T Cells in Herpes Stromal Keratitis.
Naveen K Rajasagi, Barry T Rouse.
Front Immunol, 2019 Apr 04; 10. PMID: 30941142    Free PMC article.
Deciphering the Roles of Innate Lymphoid Cells in Cancer.
Melanie Bruchard, Francois Ghiringhelli.
Front Immunol, 2019 Apr 27; 10. PMID: 31024531    Free PMC article.
Highly Cited. Review.
IL-33 Mediated Inflammation in Chronic Respiratory Diseases-Understanding the Role of the Member of IL-1 Superfamily.
Agata Gabryelska, Piotr Kuna, +2 authors, Michał Panek.
Front Immunol, 2019 May 07; 10. PMID: 31057533    Free PMC article.
An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease.
Liang Shao, Shan Pan, +9 authors, Albert K W Lie.
Front Immunol, 2019 Jun 28; 10. PMID: 31244831    Free PMC article.
Reparative T lymphocytes in organ injury.
Franco R D'Alessio, Johanna T Kurzhagen, Hamid Rabb.
J Clin Invest, 2019 Jul 02; 129(7). PMID: 31259743    Free PMC article.
Metabolites released from apoptotic cells act as tissue messengers.
Christopher B Medina, Parul Mehrotra, +9 authors, Kodi S Ravichandran.
Nature, 2020 Apr 03; 580(7801). PMID: 32238926    Free PMC article.
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.
Dongsheng Shang, Danlin Sun, +5 authors, Zhigang Tu.
Aging Cell, 2020 Apr 24; 19(5). PMID: 32323422    Free PMC article.
Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.
Ian C Boothby, Jarish N Cohen, Michael D Rosenblum.
Sci Immunol, 2020 May 03; 5(47). PMID: 32358172    Free PMC article.
Early-Life Respiratory Syncytial Virus Infection, Trained Immunity and Subsequent Pulmonary Diseases.
Carrie-Anne Malinczak, Nicholas W Lukacs, Wendy Fonseca.
Viruses, 2020 May 08; 12(5). PMID: 32375305    Free PMC article.
Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma.
Yu-Wen Huang, Chih-Yang Lin, +9 authors, Chih-Hsin Tang.
Aging (Albany NY), 2020 May 20; 12(10). PMID: 32428872    Free PMC article.
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
Alma Zernecke, Holger Winkels, +16 authors, Klaus Ley.
Circ Res, 2020 Jul 17; 127(3). PMID: 32673538    Free PMC article.
Ambiguous roles and potential therapeutic strategies of innate lymphoid cells in different types of tumor.
Shijie Wang, Pin Wu, Yongyuan Chen, Ying Chai.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724393    Free PMC article.
Molecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis.
Harry D Dawson, Celine Chen, +6 authors, Joseph F Urban.
Sci Rep, 2020 Aug 01; 10(1). PMID: 32732949    Free PMC article.
The Heterogeneity, Origins, and Impact of Migratory iILC2 Cells in Anti-helminth Immunity.
Mindy M Miller, R Lee Reinhardt.
Front Immunol, 2020 Aug 15; 11. PMID: 32793230    Free PMC article.
The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing.
Kavya L Singampalli, Swathi Balaji, +6 authors, Sundeep G Keswani.
Front Cell Dev Biol, 2020 Aug 28; 8. PMID: 32850791    Free PMC article.
Tissue regulatory T cells.
Prudence PokWai Lui, Inchul Cho, Niwa Ali.
Immunology, 2020 May 29; 161(1). PMID: 32463116    Free PMC article.
IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner.
E C Halvorsen, S E Franks, +7 authors, K L Bennewith.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713780    Free PMC article.
The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia.
Brandon N VanderVeen, E Angela Murphy, James A Carson.
Front Physiol, 2020 Sep 29; 11. PMID: 32982782    Free PMC article.
LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation.
Muchaala Yeboah, Charys Papagregoriou, +18 authors, Ali Roghanian.
JCI Insight, 2020 Sep 02; 5(18). PMID: 32870822    Free PMC article.
Is There a Role for Basophils in Cancer?
Giancarlo Marone, John T Schroeder, +6 authors, Gilda Varricchi.
Front Immunol, 2020 Oct 06; 11. PMID: 33013885    Free PMC article.
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Linh T Bui, Nichelle I Winters, +19 authors, Human Cell Atlas Lung Biological Network.
bioRxiv, 2020 Oct 28;. PMID: 33106805    Free PMC article.
The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation.
Yuichi Akama, Naoko Satoh-Takayama, +5 authors, Motomu Shimaoka.
Diagnostics (Basel), 2020 Oct 16; 10(10). PMID: 33053762    Free PMC article.
Abundance of Non-Polarized Lung Macrophages with Poor Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).
Kentaro Akata, Kei Yamasaki, +8 authors, Stephan F van Eeden.
Biomedicines, 2020 Oct 15; 8(10). PMID: 33050042    Free PMC article.
The transition of M-CSF-derived human macrophages to a growth-promoting phenotype.
Kajal Hamidzadeh, Ashton T Belew, Najib M El-Sayed, David M Mosser.
Blood Adv, 2020 Nov 10; 4(21). PMID: 33166408    Free PMC article.
Neural Regulation of Interactions Between Group 2 Innate Lymphoid Cells and Pulmonary Immune Cells.
Weiwei Chen, Qiang Shu, Jie Fan.
Front Immunol, 2020 Nov 17; 11. PMID: 33193374    Free PMC article.
Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma.
Mahmood Yaseen Hachim, Noha Mousaad Elemam, +9 authors, Rifat Hamoudi.
Front Med (Lausanne), 2020 Nov 17; 7. PMID: 33195308    Free PMC article.
Whole Transcriptome Analysis of Myeloid Dendritic Cells Reveals Distinct Genetic Regulation in Patients with Allergies.
Kijeong Lee, Mi-Ryung Han, +2 authors, Tae Hoon Kim.
Int J Mol Sci, 2020 Nov 20; 21(22). PMID: 33207814    Free PMC article.
The Evaluation of AREG, MMP-2, CHI3L1, GFAP, and OPN Serum Combined Value in Astrocytic Glioma Patients' Diagnosis and Prognosis.
Rūta Urbanavičiūtė, Kęstutis Skauminas, Daina Skiriutė.
Brain Sci, 2020 Nov 25; 10(11). PMID: 33227903    Free PMC article.
Group 2 Innate Lymphoid Cells: A Double-Edged Sword in Cancer?
Enrico Maggi, Irene Veneziani, +2 authors, Francesco Annunziato.
Cancers (Basel), 2020 Nov 26; 12(11). PMID: 33233582    Free PMC article.
Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica.
Chunsheng Yang, Yang Yang, +4 authors, Guoqiang Chang.
Int J Mol Med, 2019 Jan 11; 43(3). PMID: 30628649    Free PMC article.
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Erminia Mariani, Gina Lisignoli, Rosa Maria Borzì, Lia Pulsatelli.
Int J Mol Sci, 2019 Feb 06; 20(3). PMID: 30717232    Free PMC article.
Highly Cited. Review.
Type 2 Innate Lymphoid Cells in Liver and Gut: From Current Knowledge to Future Perspectives.
Aaron Ochel, Gisa Tiegs, Katrin Neumann.
Int J Mol Sci, 2019 Apr 20; 20(8). PMID: 30999584    Free PMC article.
Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit.
Rama Shankar, Mara L Leimanis, +9 authors, Surender Rajasekaran.
EBioMedicine, 2020 Nov 29; 62. PMID: 33248372    Free PMC article.
Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis.
Samantha M Golomb, Ian H Guldner, +7 authors, Siyuan Zhang.
Cell Rep, 2020 Dec 03; 33(9). PMID: 33264626    Free PMC article.
Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice.
Shanshan Tang, Mingfeng Zhang, +7 authors, Defu Zeng.
Proc Natl Acad Sci U S A, 2020 Nov 25; 117(49). PMID: 33229527    Free PMC article.
Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn.
Dan Yan, Fei Yu, +8 authors, Chunyi Shao.
Invest Ophthalmol Vis Sci, 2020 Dec 17; 61(14). PMID: 33326018    Free PMC article.
Function of innate lymphoid cells in the immune-related disorders.
Tanja Dzopalić, Biljana Božić-Nedeljković, Vladimir Jurišić.
Hum Cell, 2019 May 13; 32(3). PMID: 31079327
Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection.
Allen F Ryan, Chanond A Nasamran, +4 authors, Arwa Kurabi.
Front Genet, 2020 May 01; 11. PMID: 32351546    Free PMC article.
In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals.
Seung Seob Son, Soohyun Hwang, +7 authors, Eun Young Lee.
Sci Rep, 2021 Jan 28; 11(1). PMID: 33500443    Free PMC article.
Amphiregulin Regulates Melanocytic Senescence.
Michaela Pommer, Silke Kuphal, Anja K Bosserhoff.
Cells, 2021 Feb 11; 10(2). PMID: 33562468    Free PMC article.
Macrophages in Lung Injury, Repair, and Fibrosis.
Peiyong Cheng, Shuangyan Li, Huaiyong Chen.
Cells, 2021 Mar 07; 10(2). PMID: 33670759    Free PMC article.
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Caspar Schiffers, Cheryl van de Wetering, +8 authors, Albert van der Vliet.
JCI Insight, 2020 Dec 11; 6(2). PMID: 33301419    Free PMC article.
Untangling Local Pro-Inflammatory, Reparative, and Regulatory Damage-Associated Molecular-Patterns (DAMPs) Pathways to Improve Transplant Outcomes.
Gaelen K Dwyer, Hēth R Turnquist.
Front Immunol, 2021 Mar 13; 12. PMID: 33708206    Free PMC article.
Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort.
Isabel Drake, George Hindy, +4 authors, Marju Orho-Melander.
Sci Rep, 2021 Mar 26; 11(1). PMID: 33762603    Free PMC article.
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy.
Vincenzo Salemme, Giorgia Centonze, +2 authors, Laura Conti.
Front Oncol, 2021 Mar 30; 11. PMID: 33777750    Free PMC article.
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract.
Tim Flerlage, David F Boyd, +2 authors, Stacey Schultz-Cherry.
Nat Rev Microbiol, 2021 Apr 08; 19(7). PMID: 33824495    Free PMC article.
The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration.
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic.
Int J Mol Sci, 2021 Apr 04; 22(5). PMID: 33804369    Free PMC article.
Insights Into Human Intrahepatic NK Cell Function From Single Cell RNA Sequencing Datasets.
Gráinne Jameson, Mark W Robinson.
Front Immunol, 2021 Apr 09; 12. PMID: 33828559    Free PMC article.
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.
Egle Kvedaraite, Laura Hertwig, +22 authors, Karolinska KI/K COVID-19 Study Group.
Proc Natl Acad Sci U S A, 2021 Jan 23; 118(6). PMID: 33479167    Free PMC article.
T resident helper cells promote humoral responses in the lung.
Nivedya Swarnalekha, David Schreiner, +7 authors, Carolyn G King.
Sci Immunol, 2021 Jan 10; 6(55). PMID: 33419790    Free PMC article.
IL-33-mediated Eosinophilia Protects against Acute Lung Injury.
Paulette A Krishack, Maile K Hollinger, +5 authors, Philip A Verhoef.
Am J Respir Cell Mol Biol, 2021 Feb 12; 64(5). PMID: 33571420    Free PMC article.
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Hani Harb, Mehdi Benamar, +30 authors, Talal A Chatila.
Immunity, 2021 Apr 30; 54(6). PMID: 33915108    Free PMC article.
Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury.
Ryota Sakai, Minako Ito, +9 authors, Akihiko Yoshimura.
Cell Mol Immunol, 2020 Sep 13; 18(5). PMID: 32917984    Free PMC article.
Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes.
Joshua R Cox, Sheena M Cruickshank, Amy E Saunders.
Front Immunol, 2021 May 04; 12. PMID: 33936115    Free PMC article.
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions.
Giuseppe Ercolano, Alejandra Gomez-Cadena, +14 authors, Camilla Jandus.
Nat Commun, 2021 May 07; 12(1). PMID: 33953160    Free PMC article.
Role of ILC2 in Viral-Induced Lung Pathogenesis.
Wendy Fonseca, Nicholas W Lukacs, Srikanth Elesela, Carrie-Anne Malinczak.
Front Immunol, 2021 May 07; 12. PMID: 33953732    Free PMC article.
Critical role of interferons in gastrointestinal injury repair.
Constance McElrath, Vanessa Espinosa, +15 authors, Sergei V Kotenko.
Nat Commun, 2021 May 13; 12(1). PMID: 33976143    Free PMC article.
Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.
Liangxing Guo, Zhaokun Mu, +7 authors, Mengyun Li.
Sci Rep, 2021 May 15; 11(1). PMID: 33986327    Free PMC article.
Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing.
Chen Hu, Chenyu Chu, +7 authors, Yi Man.
Sci Adv, 2021 May 28; 7(22). PMID: 34039601    Free PMC article.
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma.
Nicolas Jacquelot, Cyril Seillet, +34 authors, Gabrielle T Belz.
Nat Immunol, 2021 Jun 09; 22(7). PMID: 34099918    Free PMC article.
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Moshit Lindzen, Soma Ghosh, +13 authors, Yosef Yarden.
Oncogene, 2021 May 05; 40(21). PMID: 33941851    Free PMC article.
Sex hormone regulation of innate lymphoid cells.
Eve Blanquart, Sophie Laffont, Jean-Charles Guéry.
Biomed J, 2021 Apr 24; 44(2). PMID: 33888441    Free PMC article.
Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment.
Ran Ran, Haoqing Yang, +3 authors, Ying Zheng.
BMC Oral Health, 2021 Jun 23; 21(1). PMID: 34154572    Free PMC article.
Acute Effects on the Human Peripheral Blood Transcriptome of Decompression Sickness Secondary to Scuba Diving.
Kurt Magri, Ingrid Eftedal, +4 authors, Nikolai Paul Pace.
Front Physiol, 2021 Jun 29; 12. PMID: 34177613    Free PMC article.
Identification of Monocytes Associated with Severe COVID-19 in the PBMCs of Severely Infected patients Through Single-Cell Transcriptome Sequencing.
Yan Zhang, Shuting Wang, +9 authors, Lanjuan Li.
Engineering (Beijing), 2021 Jun 22;. PMID: 34150352    Free PMC article.
The Janus Face of IL-33 Signaling in Tumor Development and Immune Escape.
Mi-Ran Choi, Jeffrey A Sosman, Bin Zhang.
Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34209038    Free PMC article.
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Linh T Bui, Nichelle I Winters, +19 authors, Human Cell Atlas Lung Biological Network.
Nat Commun, 2021 Jul 16; 12(1). PMID: 34262047    Free PMC article.
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Zheng Fu, Joseph W Dean, +6 authors, Liang Zhou.
Nat Commun, 2021 Jul 24; 12(1). PMID: 34294718    Free PMC article.
Nanoencapsulated Doxorubicin Prevents Mucositis Development in Mice.
Cristiane M Pinto, Laila S Horta, +7 authors, Gisele A C Goulart.
Pharmaceutics, 2021 Aug 11; 13(7). PMID: 34371713    Free PMC article.
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy.
Laura A Huppert, Michael D Green, +4 authors, James C Lee.
Cell Mol Immunol, 2021 Aug 22; 19(1). PMID: 34417572    Free PMC article.
Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia.
Alex R Schuurman, Tom DY Reijnders, +9 authors, Tom van der Poll.
Elife, 2021 Aug 24; 10. PMID: 34424199    Free PMC article.
Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection.
N Bhaskaran, E Schneider, +9 authors, P Pandiyan.
Nat Commun, 2021 Aug 28; 12(1). PMID: 34446704    Free PMC article.
Serum Amphiregulin and Heparin-Binding Epidermal Growth Factor as Biomarkers in Patients with Idiopathic Inflammatory Myopathy.
Norio Hanata, Yasuo Nagafuchi, +5 authors, Keishi Fujio.
J Clin Med, 2021 Aug 28; 10(16). PMID: 34442026    Free PMC article.
Interactions between islets and regulatory immune cells in health and type 1 diabetes.
Matthew A Budd, Mahdis Monajemi, +3 authors, Megan K Levings.
Diabetologia, 2021 Sep 23; 64(11). PMID: 34550422
C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived Macrophages.
Jacquelyn C Serfecz, Afsoon Saadin, +4 authors, Ricardo A Feldman.
Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34576075    Free PMC article.
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease.
Sheila K Pierson, Sushila Shenoy, +22 authors, David C Fajgenbaum.
Blood Adv, 2021 Aug 27; 5(17). PMID: 34438448    Free PMC article.
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.
Florian Klemm, Roeltje R Maas, +11 authors, Johanna A Joyce.
Cell, 2020 May 30; 181(7). PMID: 32470396    Free PMC article.
Interleukin-2 and regulatory T cells in rheumatic diseases.
Antonios G A Kolios, George C Tsokos, David Klatzmann.
Nat Rev Rheumatol, 2021 Nov 04; 17(12). PMID: 34728817
Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells.
Shang Chen, Haoyan Huang, +10 authors, Zongjin Li.
iScience, 2021 Nov 09; 24(11). PMID: 34746706    Free PMC article.
Tissue-Specific Molecular Markers and Heterogeneity in Type 2 Innate Lymphoid Cells.
Enrique Olguín-Martínez, Blanca E Ruiz-Medina, Paula Licona-Limón.
Front Immunol, 2021 Nov 12; 12. PMID: 34759931    Free PMC article.
Type 2 immunity in intestinal homeostasis and inflammatory bowel disease.
Xinxin Luo, Eduardo J Villablanca.
Biochem Soc Trans, 2021 Sep 29; 49(5). PMID: 34581755    Free PMC article.
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice.
Ming Zhao, Yingyao Quan, +10 authors, Chu-Xia Deng.
Int J Biol Sci, 2021 Nov 23; 17(15). PMID: 34803491    Free PMC article.
Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin.
Salvatore J Coniglio, Jeffrey E Segall.
PLoS One, 2021 Nov 30; 16(11). PMID: 34843542    Free PMC article.
Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling.
Joel Zindel, Jonas Mittner, +13 authors, Daniel Candinas.
Nat Commun, 2021 Dec 18; 12(1). PMID: 34916513    Free PMC article.
Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease.
Satoshi Kubo, Jill M Fritz, +31 authors, Michael J Lenardo.
Nat Immunol, 2021 Dec 24; 23(1). PMID: 34937930
Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.
Christopher M Dustin, Aida Habibovic, +8 authors, Albert van der Vliet.
J Immunol, 2021 Jun 06; 206(12). PMID: 34088769    Free PMC article.
Disease Tolerance during Viral-Bacterial Co-Infections.
Tarani Kanta Barman, Dennis W Metzger.
Viruses, 2021 Dec 29; 13(12). PMID: 34960631    Free PMC article.
IL-33, an Alarmin of the IL-1 Family Involved in Allergic and Non Allergic Inflammation: Focus on the Mechanisms of Regulation of Its Activity.
Corinne Cayrol.
Cells, 2022 Jan 12; 11(1). PMID: 35011670    Free PMC article.
Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD.
Danny W Bruce, Oleg Kolupaev, +5 authors, Jonathan S Serody.
Blood Adv, 2021 Oct 08; 5(22). PMID: 34619767    Free PMC article.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
Avraham Unterman, Tomokazu S Sumida, +46 authors, Charles S Dela Cruz.
Nat Commun, 2022 Jan 23; 13(1). PMID: 35064122    Free PMC article.
Cytokine Elevation in Severe COVID-19 From Longitudinal Proteomics Analysis: Comparison With Sepsis.
Takeshi Ebihara, Hisatake Matsumoto, +9 authors, Hiroshi Ogura.
Front Immunol, 2022 Feb 01; 12. PMID: 35095877    Free PMC article.
Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair.
Kelly Walton, Kirsti Walker, +19 authors, Brian C Betts.
Am J Transplant, 2021 Oct 21; 22(3). PMID: 34668635    Free PMC article.
Involvement of IL-33 in the Pathophysiology of Systemic Lupus Erythematosus: Review.
Julie Sarrand, Muhammad Soyfoo.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328556    Free PMC article.
The Discovery, Validation, and Function of Hypoxia-Related Gene Biomarkers for Obstructive Sleep Apnea.
Xiaofeng Wu, Zhou Pan, +4 authors, Ke Hu.
Front Med (Lausanne), 2022 Apr 05; 9. PMID: 35372438    Free PMC article.
Tissue remodeling by an opportunistic pathogen triggers allergic inflammation.
Karen Agaronyan, Lokesh Sharma, +8 authors, Ruslan Medzhitov.
Immunity, 2022 Apr 29; 55(5). PMID: 35483356    Free PMC article.
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity.
Jihye Han, Qingqing Wan, +5 authors, Yun-Cai Liu.
J Exp Med, 2022 May 10; 219(6). PMID: 35532553    Free PMC article.