Review
. 2015 Feb; 42(2):216-226.
doi: 10.1016/j.immuni.2015.01.020.

Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair

Dietmar M W Zaiss 1 William C Gause 2 Lisa C Osborne 3 David Artis 4 
Affiliations
  • PMID: 25692699
  •     116 References
  •     192 citations

Abstract

Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms, allergens, and infectious agents, and play critical roles in resistance and tolerance associated with infection, wound healing, tissue repair, and tumor development. Emerging data suggest that in addition to characteristic type 2-associated cytokines, the epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of type 2-mediated resistance and tolerance. Notably, numerous studies demonstrate that in addition to the established role of epithelial- and mesenchymal-derived AREG, multiple leukocyte populations including mast cells, basophils, group 2 innate lymphoid cells (ILC2s), and a subset of tissue-resident regulatory CD4(+) T cells can express AREG. In this review, we discuss recent advances in our understanding of the AREG-EGF receptor pathway and its involvement in infection and inflammation and propose a model for the function of this pathway in the context of resistance and tissue tolerance.

Amphiregulin production by human eosinophils.
Kenji Matsumoto, Shuhei Fukuda, Yuri Nakamura, Hirohisa Saito.
Int Arch Allergy Immunol, 2009 Jun 12; 149 Suppl 1. PMID: 19494503
Epidermal EGFR controls cutaneous host defense and prevents inflammation.
Beate M Lichtenberger, Peter A Gerber, +15 authors, Maria Sibilia.
Sci Transl Med, 2013 Aug 24; 5(199). PMID: 23966300
Highly Cited.
Modulation of the receptor binding affinity of amphiregulin by modification of its carboxyl terminal tail.
R Adam, D R Drummond, +4 authors, D E Davies.
Biochim Biophys Acta, 1995 Apr 06; 1266(1). PMID: 7718625
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.
C J Marshall.
Cell, 1995 Jan 27; 80(2). PMID: 7834738
Highly Cited. Review.
Allergic host defences.
Noah W Palm, Rachel K Rosenstein, Ruslan Medzhitov.
Nature, 2012 Apr 28; 484(7395). PMID: 22538607    Free PMC article.
Highly Cited.
Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.
Yang Zhou, Jae-Young Lee, +8 authors, Chun Geun Lee.
J Biol Chem, 2012 Oct 23; 287(50). PMID: 23086930    Free PMC article.
Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression.
Chantal Meulenbroeks, Huib van Weelden, +6 authors, Dietmar M W Zaiss.
J Invest Dermatol, 2014 Aug 05; 135(1). PMID: 25089660
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
Tao Zheng, Wei Liu, +6 authors, Jack A Elias.
J Immunol, 2007 Dec 22; 180(1). PMID: 18097054
Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response.
Monica G Chiaramonte, Margaret Mentink-Kane, +8 authors, Thomas A Wynn.
J Exp Med, 2003 Mar 19; 197(6). PMID: 12642601    Free PMC article.
Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation.
L Schuger, G R Johnson, +2 authors, R Mandel.
Development, 1996 Jun 01; 122(6). PMID: 8674415
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
Maryam Salimi, Jillian L Barlow, +9 authors, Graham S Ogg.
J Exp Med, 2013 Dec 11; 210(13). PMID: 24323357    Free PMC article.
Highly Cited.
Human keratinocytes' response to injury upregulates CCL20 and other genes linking innate and adaptive immunity.
Milène Kennedy-Crispin, Erika Billick, +7 authors, James G Krueger.
J Invest Dermatol, 2011 Sep 02; 132(1). PMID: 21881590    Free PMC article.
Mast cells are essential intermediaries in regulatory T-cell tolerance.
Li-Fan Lu, Evan F Lind, +10 authors, Randolph J Noelle.
Nature, 2006 Aug 22; 442(7106). PMID: 16921386
Highly Cited.
Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice.
Naoki Kajiwara, Keisuke Oboki, +5 authors, Susumu Nakae.
Allergol Int, 2010 Apr 24; 59(2). PMID: 20414053
Regulation of amphiregulin mRNA by TGF-beta in the human lung adenocarcinoma cell line A549.
K L Bennett, G D Plowman, +2 authors, A F Purchio.
Growth Factors, 1992 Jan 01; 7(3). PMID: 1457126
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
Jose E Heredia, Lata Mukundan, +5 authors, Ajay Chawla.
Cell, 2013 Apr 16; 153(2). PMID: 23582327    Free PMC article.
Highly Cited.
IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.
Jan-Eric Turner, Peter J Morrison, +6 authors, Brigitta Stockinger.
J Exp Med, 2013 Nov 20; 210(13). PMID: 24249111    Free PMC article.
Highly Cited.
Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.
Jennifer L Macdonald-Obermann, Linda J Pike.
J Biol Chem, 2014 Aug 03; 289(38). PMID: 25086039    Free PMC article.
Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts.
Shen-Wu Wang, Chad K Oh, +6 authors, Zhengbin Yao.
J Allergy Clin Immunol, 2005 Feb 08; 115(2). PMID: 15696083
Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer.
Michiyo Yamada, Yasushi Ichikawa, +7 authors, Hiroshi Shimada.
Clin Cancer Res, 2008 Apr 17; 14(8). PMID: 18413824
Muc5ac: a critical component mediating the rejection of enteric nematodes.
Sumaira Z Hasnain, Christopher M Evans, +8 authors, David J Thornton.
J Exp Med, 2011 Apr 20; 208(5). PMID: 21502330    Free PMC article.
Highly Cited.
Distinct effects of EGFR ligands on human mammary epithelial cell differentiation.
Chandrani Mukhopadhyay, Xiangshan Zhao, +2 authors, Mayumi Naramura.
PLoS One, 2013 Oct 15; 8(10). PMID: 24124521    Free PMC article.
Inflammatory cells during wound repair: the good, the bad and the ugly.
Paul Martin, S Joseph Leibovich.
Trends Cell Biol, 2005 Oct 06; 15(11). PMID: 16202600
Highly Cited. Review.
Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.
Nandini Krishnamoorthy, Patrick R Burkett, +8 authors, Bruce D Levy.
J Immunol, 2014 Dec 30; 194(3). PMID: 25539814    Free PMC article.
Highly Cited.
Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.
Timothy D Le Cras, Thomas H Acciani, +10 authors, Gurjit K Khurana Hershey.
Am J Physiol Lung Cell Mol Physiol, 2011 Jan 13; 300(3). PMID: 21224214    Free PMC article.
Feedback regulation of EGFR signalling: decision making by early and delayed loops.
Roi Avraham, Yosef Yarden.
Nat Rev Mol Cell Biol, 2011 Jan 22; 12(2). PMID: 21252999
Highly Cited. Review.
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells.
Isobel S Okoye, Stephanie M Coomes, +5 authors, Mark S Wilson.
Immunity, 2014 Jul 19; 41(1). PMID: 25035954    Free PMC article.
Highly Cited.
FcepsilonRI-mediated amphiregulin production by human mast cells increases mucin gene expression in epithelial cells.
Shigeru Okumura, Hironori Sagara, +2 authors, Yoshimichi Okayama.
J Allergy Clin Immunol, 2005 Feb 08; 115(2). PMID: 15696081
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis.
Maria J Perugorria, M Ujue Latasa, +9 authors, Matias A Avila.
Hepatology, 2008 Jul 18; 48(4). PMID: 18634036
IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells.
Steven A Saenz, Mark C Siracusa, +8 authors, David Artis.
J Exp Med, 2013 Aug 21; 210(9). PMID: 23960191    Free PMC article.
Highly Cited.
Amphiregulin promotes the immunosuppressive activity of intrahepatic CD4+ regulatory T cells to impair CD8+ T-cell immunity against hepatitis B virus infection.
Kai Dai, Ling Huang, +2 authors, Zuojiong Gong.
Immunology, 2014 Oct 10; 144(3). PMID: 25298208    Free PMC article.
IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
Emily Hams, Michelle E Armstrong, +11 authors, Padraic G Fallon.
Proc Natl Acad Sci U S A, 2013 Dec 18; 111(1). PMID: 24344271    Free PMC article.
Highly Cited.
Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.
Michele A Grimbaldeston, Susumu Nakae, +2 authors, Stephen J Galli.
Nat Immunol, 2007 Sep 04; 8(10). PMID: 17767162
Highly Cited.
Neutrophils in cystic fibrosis display a distinct gene expression pattern.
Minou Adib-Conquy, Thierry Pedron, +5 authors, Jean-Marc Cavaillon.
Mol Med, 2007 Nov 21; 14(1-2). PMID: 18026571    Free PMC article.
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Mark C Siracusa, Steven A Saenz, +14 authors, David Artis.
Nature, 2011 Aug 16; 477(7363). PMID: 21841801    Free PMC article.
Highly Cited.
IL-13 signaling via IL-13Rα2 triggers TGF-β1-dependent allograft fibrosis.
Stefan M Brunner, Gabriela Schiechl, +5 authors, Stefan Fichtner-Feigl.
Transplant Res, 2013 Oct 23; 2(1). PMID: 24143891    Free PMC article.
New paradigms in type 2 immunity.
Bali Pulendran, David Artis.
Science, 2012 Jul 28; 337(6093). PMID: 22837519    Free PMC article.
Highly Cited. Review.
Amphiregulin.
Carmen Berasain, Matías A Avila.
Semin Cell Dev Biol, 2014 Jan 28; 28. PMID: 24463227
Highly Cited. Review.
A2B adenosine receptor induces protective antihelminth type 2 immune responses.
Nirav Patel, Wenhui Wu, +7 authors, William C Gause.
Cell Host Microbe, 2014 Mar 19; 15(3). PMID: 24629340
Encoding and decoding cellular information through signaling dynamics.
Jeremy E Purvis, Galit Lahav.
Cell, 2013 Mar 05; 152(5). PMID: 23452846    Free PMC article.
Highly Cited. Review.
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection.
P'ng Loke, Iain Gallagher, +5 authors, Judith E Allen.
J Immunol, 2007 Sep 06; 179(6). PMID: 17785830
Highly Cited.
Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin.
Jinyi Shao, Sean B Lee, +2 authors, Hongmiao Sheng.
Cancer Res, 2003 Sep 23; 63(17). PMID: 14500348
ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics.
Carlos L Arteaga, Jeffrey A Engelman.
Cancer Cell, 2014 Mar 22; 25(3). PMID: 24651011    Free PMC article.
Highly Cited. Review.
Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells.
S Li, G D Plowman, S D Buckley, G D Shipley.
J Cell Physiol, 1992 Oct 01; 153(1). PMID: 1522124
Oscillatory control of factors determining multipotency and fate in mouse neural progenitors.
Itaru Imayoshi, Akihiro Isomura, +6 authors, Ryoichiro Kageyama.
Science, 2013 Nov 02; 342(6163). PMID: 24179156
Highly Cited.
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection.
De'Broski R Herbert, Jun-Qi Yang, +10 authors, Fred D Finkelman.
J Exp Med, 2009 Dec 10; 206(13). PMID: 19995957    Free PMC article.
Highly Cited.
The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.
Yilin Qi, Darwin J Operario, Steve N Georas, Tim R Mosmann.
PLoS One, 2012 Jun 22; 7(6). PMID: 22720031    Free PMC article.
Amphiregulin is not essential for induction of contact hypersensitivity.
Akiko Yagami, Naoki Kajiwara, +7 authors, Susumu Nakae.
Allergol Int, 2010 Jun 23; 59(3). PMID: 20567134
Disease tolerance as a defense strategy.
Ruslan Medzhitov, David S Schneider, Miguel P Soares.
Science, 2012 Mar 01; 335(6071). PMID: 22363001    Free PMC article.
Highly Cited. Review.
Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis.
Bernice Y Kwong, Scott J Roberts, +9 authors, Michael Girardi.
J Invest Dermatol, 2009 Nov 20; 130(6). PMID: 19924136    Free PMC article.
Amphiregulin: an early trigger of liver regeneration in mice.
Carmen Berasain, Elena R García-Trevijano, +4 authors, Matías A Avila.
Gastroenterology, 2005 Feb 03; 128(2). PMID: 15685553
The route to pathologies in chronic inflammatory diseases characterized by T helper type 2 immune cells.
K Jovanovic, M Siebeck, R Gropp.
Clin Exp Immunol, 2014 Jul 02; 178(2). PMID: 24981014    Free PMC article.
Review.
Foxp3+ regulatory T cells maintain immune homeostasis in the skin.
Jan C Dudda, Nikole Perdue, Eva Bachtanian, Daniel J Campbell.
J Exp Med, 2008 Jun 25; 205(7). PMID: 18573908    Free PMC article.
The alarmin IL-33 promotes regulatory T-cell function in the intestine.
Chris Schiering, Thomas Krausgruber, +13 authors, Fiona Powrie.
Nature, 2014 Jul 22; 513(7519). PMID: 25043027    Free PMC article.
Highly Cited.
Role of tissue protection in lethal respiratory viral-bacterial coinfection.
Amanda M Jamieson, Lesley Pasman, +4 authors, Ruslan Medzhitov.
Science, 2013 Apr 27; 340(6137). PMID: 23618765    Free PMC article.
Highly Cited.
Cancer immunotherapy via dendritic cells.
Karolina Palucka, Jacques Banchereau.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871    Free PMC article.
Highly Cited. Review.
Differential roles of macrophages in diverse phases of skin repair.
Tina Lucas, Ari Waisman, +5 authors, Sabine A Eming.
J Immunol, 2010 Feb 24; 184(7). PMID: 20176743
Highly Cited.
IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer.
R S Herbst, E S Kim, P M Harari.
Expert Opin Biol Ther, 2001 Dec 01; 1(4). PMID: 11727507
Review.
EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate.
Kathryn A Stern, Trenton L Place, Nancy L Lill.
Biochem J, 2007 Nov 30; 410(3). PMID: 18045238    Free PMC article.
Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR.
B Boris Vargaftig, Monique Singer.
Am J Physiol Lung Cell Mol Physiol, 2003 Jun 10; 285(4). PMID: 12794006
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts.
A Desmoulière, A Geinoz, F Gabbiani, G Gabbiani.
J Cell Biol, 1993 Jul 01; 122(1). PMID: 8314838    Free PMC article.
Highly Cited.
Amphiregulin, a TH2 cytokine enhancing resistance to nematodes.
Dietmar M Zaiss, Li Yang, +3 authors, Tim R Mosmann.
Science, 2006 Dec 16; 314(5806). PMID: 17170297
ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion.
Nathalie Bles, Larissa Di Pietrantonio, Jean-Marie Boeynaems, Didier Communi.
Blood, 2010 Jul 24; 116(17). PMID: 20651071
Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue.
Lejla Pasic, T S Karin Eisinger-Mathason, +4 authors, Deborah A Lannigan.
Genes Dev, 2011 Aug 11; 25(15). PMID: 21828273    Free PMC article.
A special population of regulatory T cells potentiates muscle repair.
Dalia Burzyn, Wilson Kuswanto, +8 authors, Diane Mathis.
Cell, 2013 Dec 10; 155(6). PMID: 24315098    Free PMC article.
Highly Cited.
Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3.
Kjetil Ask, Philippe Bonniaud, +6 authors, Martin Kolb.
Int J Biochem Cell Biol, 2007 Oct 13; 40(3). PMID: 17931953    Free PMC article.
Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.
Nirav Patel, Timothy Kreider, Joseph F Urban, William C Gause.
Int J Parasitol, 2008 Sep 23; 39(1). PMID: 18804113    Free PMC article.
Review.
Susceptibility and immunity to helminth parasites.
Rick M Maizels, James P Hewitson, Katherine A Smith.
Curr Opin Immunol, 2012 Jul 17; 24(4). PMID: 22795966    Free PMC article.
Highly Cited. Review.
EGFR antagonists in cancer treatment.
Fortunato Ciardiello, Giampaolo Tortora.
N Engl J Med, 2008 Mar 14; 358(11). PMID: 18337605
Highly Cited. Review.
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent.
Mallika Kaviratne, Matthias Hesse, +6 authors, Thomas A Wynn.
J Immunol, 2004 Sep 10; 173(6). PMID: 15356151
Highly Cited.
Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.
Devin T Worster, Tobias Schmelzle, +5 authors, John G Albeck.
Sci Signal, 2012 Mar 08; 5(214). PMID: 22394561    Free PMC article.
Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis.
Na Liu, Jian-Kan Guo, +7 authors, Shougang Zhuang.
J Am Soc Nephrol, 2012 Mar 01; 23(5). PMID: 22362908    Free PMC article.
Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy.
Francesca Mascia, Gary Lam, +4 authors, Stuart H Yuspa.
Sci Transl Med, 2013 Aug 24; 5(199). PMID: 23966299    Free PMC article.
Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases.
David S Schneider, Janelle S Ayres.
Nat Rev Immunol, 2008 Oct 18; 8(11). PMID: 18927577    Free PMC article.
Highly Cited. Review.
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.
Stefan Fichtner-Feigl, Warren Strober, +2 authors, Atsushi Kitani.
Nat Med, 2005 Dec 06; 12(1). PMID: 16327802
Highly Cited.
Heparan sulfate: a ubiquitous glycosaminoglycan with multiple roles in immunity.
David Anak Simon Davis, Christopher R Parish.
Front Immunol, 2014 Jan 07; 4. PMID: 24391644    Free PMC article.
Efficient Treg depletion induces T-cell infiltration and rejection of large tumors.
Xingrui Li, Efterpi Kostareli, +2 authors, Günter J Hämmerling.
Eur J Immunol, 2010 Nov 13; 40(12). PMID: 21072887
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor.
S Traverse, N Gomez, +2 authors, P Cohen.
Biochem J, 1992 Dec 01; 288 ( Pt 2). PMID: 1334404    Free PMC article.
Highly Cited.
The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types.
C Christian Johansson, Arne Yndestad, +3 authors, Kjetil Taskén.
Endocrinology, 2004 Jul 31; 145(11). PMID: 15284208
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response.
M G Chiaramonte, D D Donaldson, A W Cheever, T A Wynn.
J Clin Invest, 1999 Sep 24; 104(6). PMID: 10491413    Free PMC article.
Highly Cited.
Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells.
H Kimura, D Schubert.
J Cell Biol, 1992 Feb 01; 116(3). PMID: 1530950    Free PMC article.
Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor.
G R Johnson, L Wong.
J Biol Chem, 1994 Oct 28; 269(43). PMID: 7929459
Emerging perspectives in epidermal growth factor receptor targeting in head and neck cancer.
Seungwon Kim, Jennifer R Grandis, +2 authors, Alfio Ferlito.
Head Neck, 2008 Apr 03; 30(5). PMID: 18383530
Review.
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.
William C Gause, Thomas A Wynn, Judith E Allen.
Nat Rev Immunol, 2013 Jul 06; 13(8). PMID: 23827958    Free PMC article.
Highly Cited. Review.
Cutaneous manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.
M Halabi-Tawil, F M Ruemmele, +7 authors, C Bodemer.
Br J Dermatol, 2008 Sep 18; 160(3). PMID: 18795917
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).
C G Lee, R J Homer, +9 authors, J A Elias.
J Exp Med, 2001 Sep 19; 194(6). PMID: 11560996    Free PMC article.
Highly Cited.
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses.
R P Sutmuller, L M van Duivenvoorde, +6 authors, C J Melief.
J Exp Med, 2001 Sep 19; 194(6). PMID: 11560997    Free PMC article.
Highly Cited.
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.
Ki Young Chung, Jinru Shia, +11 authors, Leonard B Saltz.
J Clin Oncol, 2005 Jan 29; 23(9). PMID: 15677699
Highly Cited.
Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion.
Laura J Cliffe, Neil E Humphreys, +3 authors, Richard K Grencis.
Science, 2005 Jun 04; 308(5727). PMID: 15933199
Highly Cited.
The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection.
Laura J Cliffe, Richard K Grencis.
Adv Parasitol, 2004 Oct 27; 57. PMID: 15504540
Review.
Oscillatory dynamics of the extracellular signal-regulated kinase pathway.
Harish Shankaran, H Steven Wiley.
Curr Opin Genet Dev, 2010 Sep 03; 20(6). PMID: 20810275
Review.
Differential effects of amphiregulin and TGF-alpha on the morphology of MDCK cells.
Eunkyung Chung, Ramona Graves-Deal, Jeffrey L Franklin, Robert J Coffey.
Exp Cell Res, 2005 Jun 28; 309(1). PMID: 15979068
Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.
Hirotaka Suga, Robert C Rennert, +6 authors, Geoffrey C Gurtner.
Stem Cells, 2014 Jan 22; 32(5). PMID: 24446236    Free PMC article.
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
N C Luetteke, T H Qiu, +4 authors, D C Lee.
Development, 1999 May 20; 126(12). PMID: 10331984
Highly Cited.
Efficient colonic mucosal wound repair requires Trem2 signaling.
Hiroshi Seno, Hiroyuki Miyoshi, +3 authors, Thaddeus S Stappenbeck.
Proc Natl Acad Sci U S A, 2008 Dec 26; 106(1). PMID: 19109436    Free PMC article.
Mast cell mediators in tolerance.
Victor C de Vries, Randolph J Noelle.
Curr Opin Immunol, 2010 Oct 05; 22(5). PMID: 20884193    Free PMC article.
Review.
Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1.
D A Vardy, C Kari, +4 authors, U Rodeck.
J Cell Physiol, 1995 May 01; 163(2). PMID: 7706370
Binding specificities and affinities of egf domains for ErbB receptors.
J T Jones, R W Akita, M X Sliwkowski.
FEBS Lett, 1999 Apr 24; 447(2-3). PMID: 10214951
Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells.
Dennis B Leveson-Gower, Emanuela I Sega, +5 authors, Robert S Negrin.
Blood, 2013 Sep 14; 122(22). PMID: 24030387    Free PMC article.
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study.
Barbara Burtness, Meredith A Goldwasser, +3 authors, Eastern Cooperative Oncology Group.
J Clin Oncol, 2005 Nov 30; 23(34). PMID: 16314626
Highly Cited.
Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.
M Shoyab, V L McDonald, J G Bradley, G J Todaro.
Proc Natl Acad Sci U S A, 1988 Sep 01; 85(17). PMID: 3413110    Free PMC article.
Highly Cited.
Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.
Judith E Allen, Thomas A Wynn.
PLoS Pathog, 2011 May 19; 7(5). PMID: 21589896    Free PMC article.
Highly Cited.
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.
Ya-Jen Chang, Hye Young Kim, +5 authors, Dale T Umetsu.
Nat Immunol, 2011 May 31; 12(7). PMID: 21623379    Free PMC article.
Highly Cited.
A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.
P W Cook, P A Mattox, +5 authors, G D Shipley.
Mol Cell Biol, 1991 May 01; 11(5). PMID: 2017164    Free PMC article.
Dendritic cells, inflammation, and breast cancer.
Karolina Palucka, Lisa M Coussens, Joyce O'Shaughnessy.
Cancer J, 2013 Nov 26; 19(6). PMID: 24270350    Free PMC article.
Review.
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis.
Tamar McHedlidze, Maximilian Waldner, +8 authors, Stefan Wirtz.
Immunity, 2013 Aug 21; 39(2). PMID: 23954132    Free PMC article.
Highly Cited.
Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens.
Nora Branzk, Aleksandra Lubojemska, +4 authors, Venizelos Papayannopoulos.
Nat Immunol, 2014 Sep 15; 15(11). PMID: 25217981    Free PMC article.
Highly Cited.
Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells.
Karin D Rodland, Nikki Bollinger, +4 authors, H Steven Wiley.
J Biol Chem, 2008 Sep 11; 283(46). PMID: 18782770    Free PMC article.
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.
Fei Chen, Zhugong Liu, +7 authors, William C Gause.
Nat Med, 2012 Jan 17; 18(2). PMID: 22245779    Free PMC article.
Highly Cited.
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Laurel A Monticelli, Gregory F Sonnenberg, +15 authors, David Artis.
Nat Immunol, 2011 Sep 29; 12(11). PMID: 21946417    Free PMC article.
Highly Cited.
Human basophils express amphiregulin in response to T cell-derived IL-3.
Yilin Qi, Darwin J Operario, +4 authors, Tim R Mosmann.
J Allergy Clin Immunol, 2010 Nov 03; 126(6). PMID: 21036386    Free PMC article.
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
Dietmar M W Zaiss, Jorg van Loosdregt, +7 authors, Alice J A M Sijts.
Immunity, 2013 Jan 22; 38(2). PMID: 23333074    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Protective immune mechanisms in helminth infection.
Robert M Anthony, Laura I Rutitzky, +2 authors, William C Gause.
Nat Rev Immunol, 2007 Nov 17; 7(12). PMID: 18007680    Free PMC article.
Highly Cited. Review.
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.
John G Albeck, Gordon B Mills, Joan S Brugge.
Mol Cell, 2012 Dec 12; 49(2). PMID: 23219535    Free PMC article.
Highly Cited.
Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.
Q Hamid, M Boguniewicz, D Y Leung.
J Clin Invest, 1994 Aug 01; 94(2). PMID: 8040343    Free PMC article.
Highly Cited.
Angiogenic factors and inflammation in steroid-refractory acute graft-vs-host disease.
Shernan G Holtan, Mukta Arora.
Transl Res, 2015 Jun 29; 167(1). PMID: 26117290    Free PMC article.
Review.
Mutual Interaction of Basophils and T Cells in Chronic Inflammatory Diseases.
Marika Sarfati, Keiko Wakahara, Laurence Chapuy, Guy Delespesse.
Front Immunol, 2015 Aug 19; 6. PMID: 26284078    Free PMC article.
Review.
A Distinct Function of Regulatory T Cells in Tissue Protection.
Nicholas Arpaia, Jesse A Green, +5 authors, Alexander Y Rudensky.
Cell, 2015 Sep 01; 162(5). PMID: 26317471    Free PMC article.
Highly Cited.
Interferon-γ constrains cytokine production of group 2 innate lymphoid cells.
Fujimi Kudo, Masashi Ikutani, +8 authors, Satoshi Takaki.
Immunology, 2015 Oct 02; 147(1). PMID: 26425820    Free PMC article.
Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.
Kazuyo Moro, Hiroki Kabata, +7 authors, Shigeo Koyasu.
Nat Immunol, 2015 Nov 26; 17(1). PMID: 26595888
Highly Cited.
T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R.
Michelle Goritzka, Catherine Pereira, +2 authors, Cecilia Johansson.
Sci Rep, 2015 Dec 22; 5. PMID: 26688048    Free PMC article.
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Maya R Karta, David H Broide, Taylor A Doherty.
Curr Allergy Asthma Rep, 2016 Jan 10; 16(1). PMID: 26746844    Free PMC article.
Review.
CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm.
Kiyoshi Hirahara, Toshinori Nakayama.
Int Immunol, 2016 Feb 14; 28(4). PMID: 26874355    Free PMC article.
Highly Cited. Review.
Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.
Colleen M Lau, Simone A Nish, +3 authors, Boris Reizis.
J Exp Med, 2016 Feb 24; 213(3). PMID: 26903243    Free PMC article.
Nasal administration of interleukin-33 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma surrogate.
Shan Shan, Yan Li, +7 authors, Sun Ying.
Immunology, 2016 Apr 02; 148(1). PMID: 27035894    Free PMC article.
Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function.
Katharine Carney, Yu-Mei Ruby Chang, +11 authors, Oliver A Garden.
J Allergy Clin Immunol, 2016 Apr 05; 137(6). PMID: 27040371    Free PMC article.
New insights into basophil heterogeneity.
Landon K Oetjen, Mario Noti, Brian S Kim.
Semin Immunopathol, 2016 May 15; 38(5). PMID: 27178409    Free PMC article.
Review.
Possible mechanisms of host resistance to Haemonchus contortus infection in sheep breeds native to the Canary Islands.
Zhengyu Guo, Jorge Francisco González, +6 authors, Robert W Li.
Sci Rep, 2016 May 21; 6. PMID: 27197554    Free PMC article.
Bone Marrow CD11c+ Cell-Derived Amphiregulin Promotes Pulmonary Fibrosis.
Lin Ding, Tianju Liu, +5 authors, Sem H Phan.
J Immunol, 2016 May 22; 197(1). PMID: 27206766    Free PMC article.
Dendritic cells in lung immunopathology.
Peter C Cook, Andrew S MacDonald.
Semin Immunopathol, 2016 Jun 04; 38(4). PMID: 27256370    Free PMC article.
Review.
Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients.
Larry Lam, Lydia Chin, +7 authors, Milan Fiala.
FASEB J, 2016 Jul 03; 30(10). PMID: 27368295    Free PMC article.
Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors.
Shernan G Holtan, Nandita Khera, +31 authors, Joseph Pidala.
Blood, 2016 Sep 15; 128(19). PMID: 27625357    Free PMC article.
Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females.
Olivia J Hall, Nathachit Limjunyawong, +5 authors, Sabra L Klein.
PLoS Pathog, 2016 Sep 16; 12(9). PMID: 27631986    Free PMC article.
EGF receptor ligands: recent advances.
Bhuminder Singh, Graham Carpenter, Robert J Coffey.
F1000Res, 2016 Sep 17; 5. PMID: 27635238    Free PMC article.
Review.
Interleukin-33 in health and disease.
Foo Yew Liew, Jean-Philippe Girard, Heth Roderick Turnquist.
Nat Rev Immunol, 2016 Oct 27; 16(11). PMID: 27640624
Highly Cited. Review.
EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium.
Wu-Lin Zuo, Jing Yang, +3 authors, Renat Shaykhiev.
Stem Cells, 2016 Oct 07; 35(3). PMID: 27709733    Free PMC article.
Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.
Anna E Kersh, Maiko Sasaki, +2 authors, Brian P Pollack.
Front Pharmacol, 2016 Oct 13; 7. PMID: 27729860    Free PMC article.
Review.
DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.
Aida Habibovic, Milena Hristova, +9 authors, Albert van der Vliet.
JCI Insight, 2016 Nov 05; 1(18). PMID: 27812543    Free PMC article.
An Update on Lymphocyte Subtypes in Asthma and Airway Disease.
Daniel M Moldaver, Mark Larché, Christopher D Rudulier.
Chest, 2016 Nov 08; 151(5). PMID: 27818326    Free PMC article.
Review.
Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis.
Robert P Schleimer.
Annu Rev Pathol, 2016 Dec 14; 12. PMID: 27959637    Free PMC article.
Highly Cited. Review.
Type I Interferons in Bacterial Infections: A Balancing Act.
Pavel Kovarik, Virginia Castiglia, Masa Ivin, Florian Ebner.
Front Immunol, 2017 Jan 14; 7. PMID: 28082986    Free PMC article.
Highly Cited. Review.
Divide, Conquer, and Sense: CD8+CD28- T Cells in Perspective.
Fernando A Arosa, André J Esgalhado, Carolina A Padrão, Elsa M Cardoso.
Front Immunol, 2017 Jan 18; 7. PMID: 28096804    Free PMC article.
Recent developments in the role of reactive oxygen species in allergic asthma.
Jingjing Qu, Yuanyuan Li, +2 authors, Chengping Hu.
J Thorac Dis, 2017 Feb 17; 9(1). PMID: 28203435    Free PMC article.
Review.
Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease.
Danny W Bruce, Heather E Stefanski, +15 authors, Jonathan S Serody.
J Clin Invest, 2017 Apr 05; 127(5). PMID: 28375154    Free PMC article.
Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease.
Dong Hyuk Seo, Xiumei Che, +8 authors, Jae Hee Cheon.
Sci Rep, 2017 Apr 14; 7(1). PMID: 28404987    Free PMC article.
Immune-Mediated Repair: A Matter of Plasticity.
Paôline Laurent, Valérie Jolivel, +4 authors, Thomas Pradeu.
Front Immunol, 2017 May 10; 8. PMID: 28484454    Free PMC article.
Review.
New fronts emerge in the influenza cytokine storm.
Xi-Zhi J Guo, Paul G Thomas.
Semin Immunopathol, 2017 May 31; 39(5). PMID: 28555383    Free PMC article.
Highly Cited. Review.
Heart failure: Macrophages take centre stage in the heart-brain-kidney axis.
Herman H W Silljé, Rudolf A de Boer.
Nat Rev Nephrol, 2017 May 31; 13(7). PMID: 28555651
Heterogeneity and Stability in Foxp3+ Regulatory T Cells.
Booki Min.
J Interferon Cytokine Res, 2017 Jul 12; 37(9). PMID: 28696819    Free PMC article.
Review.
The Immune System's Contribution to the Clinical Efficacy of EGFR Antagonist Treatment.
Felicity MacDonald, Dietmar M W Zaiss.
Front Pharmacol, 2017 Oct 04; 8. PMID: 28970798    Free PMC article.
Review.
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
Carlos M Minutti, Sebastian Drube, +11 authors, Dietmar M Zaiss.
Immunity, 2017 Oct 19; 47(4). PMID: 29045902    Free PMC article.
Preexisting Type 2 Immune Activation Protects against the Development of Sepsis.
Paulette A Krishack, Kanix Wang, +3 authors, Philip A Verhoef.
Am J Respir Cell Mol Biol, 2017 Nov 02; 57(5). PMID: 29090959    Free PMC article.
Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer.
Anna E Kersh, Spencer Ng, +7 authors, Brian P Pollack.
J Clin Pharmacol, 2017 Nov 15; 58(1). PMID: 29136276    Free PMC article.
Review.
Editorial: On the Origin and Function of Human NK-Like CD8+ T Cells: Charting New Territories.
Fernando A Arosa.
Front Immunol, 2017 Dec 01; 8. PMID: 29187857    Free PMC article.
Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma.
Yari Ciribilli, Jürgen Borlak.
Oncotarget, 2017 Dec 20; 8(60). PMID: 29254206    Free PMC article.
Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice.
Kristi J Warren, Todd A Wyatt, +7 authors, Jill A Poole.
Safety (Basel), 2018 Feb 02; 3(1). PMID: 29387711    Free PMC article.
Biomarkers in Graft-Versus-Host Disease: from Prediction and Diagnosis to Insights into Complex Graft/Host Interactions.
Fiona C He, Shernan G Holtan.
Curr Hematol Malig Rep, 2018 Feb 02; 13(1). PMID: 29388008
Review.
Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression.
Chang-Ching Wei, Yung-Jen Kung, +8 authors, Lei Wan.
EBioMedicine, 2018 Feb 06; 28. PMID: 29398596    Free PMC article.
Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury.
Michael Koeppen, Jae W Lee, +6 authors, Holger K Eltzschig.
Nat Commun, 2018 Feb 28; 9(1). PMID: 29483579    Free PMC article.
The chemokine receptor CCR1 is identified in mast cell-derived exosomes.
Yuting Liang, Longwei Qiao, +5 authors, Li Li.
Am J Transl Res, 2018 Mar 08; 10(2). PMID: 29511430    Free PMC article.
The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology.
Marta Stolarczyk, Bob J Scholte.
Mediators Inflamm, 2018 Mar 16; 2018. PMID: 29540993    Free PMC article.
Review.
Biomarkers of chondrosarcoma.
Wonju Jeong, Ha-Jeong Kim.
J Clin Pathol, 2018 Mar 30; 71(7). PMID: 29593061    Free PMC article.
Review.
Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.
Andrea J Sant, Katherine A Richards, Jennifer Nayak.
Curr Opin Immunol, 2018 Apr 06; 53. PMID: 29621639    Free PMC article.
Review.
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis.
Barbara C Mindt, Jörg H Fritz, Claudia U Duerr.
Front Immunol, 2018 May 16; 9. PMID: 29760695    Free PMC article.
Highly Cited. Review.
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.
Alba Simats, Teresa García-Berrocoso, +6 authors, Joan Montaner.
Sci Rep, 2018 May 23; 8(1). PMID: 29784938    Free PMC article.
Live Vaccination Generates Both Disease Tolerance and Host Resistance During Chronic Pulmonary Infection With Highly Virulent Francisella tularensis SchuS4.
Alicia M Soucy, Gregory J Hurteau, Dennis W Metzger.
J Infect Dis, 2018 Jun 23; 218(11). PMID: 29931113    Free PMC article.
Production of amphiregulin and recovery from influenza is greater in males than females.
Meghan S Vermillion, Rebecca L Ursin, +12 authors, Sabra L Klein.
Biol Sex Differ, 2018 Jul 18; 9(1). PMID: 30012205    Free PMC article.
Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection.
Sapana Kadel, Susan Kovats.
Front Immunol, 2018 Aug 07; 9. PMID: 30079065    Free PMC article.
Review.
Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802.
Shernan G Holtan, Todd E DeFor, +34 authors, Margaret L MacMillan.
Blood Adv, 2018 Aug 09; 2(15). PMID: 30087106    Free PMC article.
Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions.
Siva Karthik Varanasi, Naveen K Rajasagi, Ujjaldeep Jaggi, Barry T Rouse.
Mucosal Immunol, 2018 Aug 09; 11(6). PMID: 30087443    Free PMC article.
Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-β and Contribute to Intestinal Homeostasis.
Feidi Chen, Wenjing Yang, +12 authors, Yingzi Cong.
J Immunol, 2018 Sep 02; 201(8). PMID: 30171165    Free PMC article.
Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis.
Siddharth Krishnan, Ian E Prise, +11 authors, Joanne E Konkel.
Proc Natl Acad Sci U S A, 2018 Oct 04; 115(42). PMID: 30279177    Free PMC article.
Comparative mRNA and miRNA transcriptome analysis of a mouse model of IGFIR-driven lung cancer.
Robert A Jones, Sarah E Franks, Roger A Moorehead.
PLoS One, 2018 Nov 10; 13(11). PMID: 30412601    Free PMC article.
Therapeutic administration of IL-10 and amphiregulin alleviates chronic skeletal muscle inflammation and damage induced by infection.
Richard M Jin, Jordan Warunek, Elizabeth A Wohlfert.
Immunohorizons, 2018 Nov 13; 2(5). PMID: 30417170    Free PMC article.
Sortilin as a new membrane inhibitor of EGFR trafficking for overcoming resistance to EGFR inhibitors in non-small cell lung cancer.
Qianping Li, Weijie Ma, Tianhong Li.
J Thorac Dis, 2018 Nov 16; 10(Suppl 26). PMID: 30430029    Free PMC article.
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
Wen Zhang, Qian Li, +3 authors, Yun-Cai Liu.
J Exp Med, 2018 Nov 23; 215(12). PMID: 30463876    Free PMC article.
Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation.
Esmaeil Mortaz, Saeede Amani, +5 authors, Gert Folkerts.
J Immunol Res, 2018 Dec 05; 2018. PMID: 30510964    Free PMC article.
Review.
Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and Matrix Metalloproteinases.
Christopher Platen, Stephan Dreschers, +2 authors, Thorsten W Orlikowsky.
Mediators Inflamm, 2018 Dec 14; 2018. PMID: 30524196    Free PMC article.
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Qixia Xu, Qilai Long, +12 authors, Yu Sun.
Aging Cell, 2019 Sep 08; 18(6). PMID: 31493351    Free PMC article.
Tumour Microenvironment and Immune Evasion in EGFR Addicted NSCLC: Hurdles and Possibilities.
Antonio Santaniello, Fabiana Napolitano, +5 authors, Roberto Bianco.
Cancers (Basel), 2019 Sep 27; 11(10). PMID: 31554160    Free PMC article.
Review.
Circulating Tumor Biomarkers in Meningiomas Reveal a Signature of Equilibrium Between Tumor Growth and Immune Modulation.
Erdogan Pekcan Erkan, Thomas Ströbel, +4 authors, Okay Saydam.
Front Oncol, 2019 Oct 28; 9. PMID: 31649887    Free PMC article.
T Regulatory Cells and Priming the Suppressive Tumor Microenvironment.
Christina M Paluskievicz, Xuefang Cao, +3 authors, Jonathan S Bromberg.
Front Immunol, 2019 Nov 05; 10. PMID: 31681327    Free PMC article.
Review.
Identification and Classification of Differentially Expressed Genes and Network Meta-Analysis Reveals Potential Molecular Signatures Associated With Tuberculosis.
Aftab Alam, Nikhat Imam, +5 authors, Romana Ishrat.
Front Genet, 2019 Nov 22; 10. PMID: 31749827    Free PMC article.
ILC2s: New Actors in Tumor Immunity.
Giuseppe Ercolano, Maryline Falquet, +2 authors, Camilla Jandus.
Front Immunol, 2019 Dec 19; 10. PMID: 31849977    Free PMC article.
Review.
Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease.
G Goel, A J M Daveson, +8 authors, R P Anderson.
Clin Exp Immunol, 2019 Sep 11; 199(1). PMID: 31505020    Free PMC article.
Proximal Tubule-Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis.
Eirini Kefaloyianni, Manikanda Raja Keerthi Raja, +4 authors, Andreas Herrlich.
J Am Soc Nephrol, 2019 Nov 05; 30(12). PMID: 31676723    Free PMC article.
Amphiregulin in intestinal acute graft-versus-host disease: a possible diagnostic and prognostic aid.
Khalid Amin, Usman Yaqoob, +13 authors, Shernan G Holtan.
Mod Pathol, 2018 Nov 15; 32(4). PMID: 30425334    Free PMC article.
ILC2 the Rescue?
R Stokes Peebles.
Am J Respir Crit Care Med, 2019 Sep 19; 201(1). PMID: 31532222    Free PMC article.
The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment.
Laura Ducimetière, Marijne Vermeer, Sonia Tugues.
Front Immunol, 2020 Jan 11; 10. PMID: 31921156    Free PMC article.
Review.
Trained Innate Immunity and Its Implications for Mucosal Immunity and Inflammation.
George Hajishengallis, Xiaofei Li, Ioannis Mitroulis, Triantafyllos Chavakis.
Adv Exp Med Biol, 2019 Nov 17; 1197. PMID: 31732931    Free PMC article.
Review.
Growth Factor Engineering Strategies for Regenerative Medicine Applications.
Xiaochen Ren, Moyuan Zhao, +2 authors, Ziad Julier.
Front Bioeng Biotechnol, 2020 Feb 11; 7. PMID: 32039177    Free PMC article.
Review.
Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling.
Seung Won Kim, Soochan Kim, +2 authors, Young Sook Park.
Sci Rep, 2020 Feb 12; 10(1). PMID: 32042047    Free PMC article.
Amphiregulin contributes to airway remodeling in chronic allograft dysfunction after lung transplantation.
Jamie L Todd, Fran L Kelly, +6 authors, Scott M Palmer.
Am J Transplant, 2019 Oct 31; 20(3). PMID: 31665560    Free PMC article.
Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation.
Dimitrios Kouroupis, Annie C Bowles, +5 authors, Diego Correa.
Sci Rep, 2019 Jul 28; 9(1). PMID: 31350444    Free PMC article.
ILC2s in infectious diseases and organ-specific fibrosis.
Markus Kindermann, Lisa Knipfer, Imke Atreya, Stefan Wirtz.
Semin Immunopathol, 2018 Apr 07; 40(4). PMID: 29623414
Review.
Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity.
Xi-Zhi J Guo, Pradyot Dash, +10 authors, Paul G Thomas.
Immunity, 2018 Sep 02; 49(3). PMID: 30170813    Free PMC article.
Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.
Ankit Mahendra, Xingyu Yang, +13 authors, Navin Varadarajan.
Arthritis Rheumatol, 2018 Nov 09; 71(4). PMID: 30407753    Free PMC article.
Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils.
Paulette A Krishack, Tyler J Louviere, +6 authors, Philip A Verhoef.
JCI Insight, 2019 Feb 06; 4(6). PMID: 30721149    Free PMC article.
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.
Shawn P Kubli, Christian Bassi, +30 authors, Chiara Gorrini.
Proc Natl Acad Sci U S A, 2019 Feb 09; 116(9). PMID: 30733286    Free PMC article.
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
Toufic Mayassi, Kristin Ladell, +24 authors, Bana Jabri.
Cell, 2019 Feb 12; 176(5). PMID: 30739797    Free PMC article.
A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.
Carlos M Minutti, Rucha V Modak, +14 authors, Dietmar M Zaiss.
Immunity, 2019 Feb 17; 50(3). PMID: 30770250    Free PMC article.
Highly Cited.
Immune- and non-immune-mediated roles of regulatory T-cells during wound healing.
Dietmar M Zaiss, Carlos M Minutti, Johanna A Knipper.
Immunology, 2019 Mar 14; 157(3). PMID: 30866049    Free PMC article.
Review.
The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin.
Kiyoshi Hirahara, Ami Aoki, +3 authors, Toshinori Nakayama.
Semin Immunopathol, 2019 Apr 11; 41(3). PMID: 30968186
Review.
The balance of power: innate lymphoid cells in tissue inflammation and repair.
Jim G Castellanos, Randy S Longman.
J Clin Invest, 2019 Jun 11; 129(7). PMID: 31180335    Free PMC article.
Review.
Innate immune cell-epithelial crosstalk during wound repair.
Jennifer C Brazil, Miguel Quiros, Asma Nusrat, Charles A Parkos.
J Clin Invest, 2019 Jul 23; 129(8). PMID: 31329162    Free PMC article.
Highly Cited. Review.
Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG.
Yaojia X Yaojia Cheng, Qiuping Lu, +5 authors, Chen Liu.
Int J Mol Med, 2020 Mar 04; 45(4). PMID: 32124941    Free PMC article.
Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development.
Lucas F Loffredo, Mackenzie E Coden, +9 authors, Sergejs Berdnikovs.
Sci Rep, 2020 Mar 12; 10(1). PMID: 32157178    Free PMC article.
Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response.
Wei Mu, Jan Provaznik, Thilo Hackert, Margot Zöller.
Cells, 2020 Feb 06; 9(2). PMID: 32013145    Free PMC article.
Emerging Roles of Interleukin-33-responsive Kidney Group 2 Innate Lymphoid Cells in Acute Kidney Injury.
Wei-Yu Chen, Lung-Chih Li, +2 authors, Hong-Tai Tzeng.
Int J Mol Sci, 2020 Feb 28; 21(4). PMID: 32102434    Free PMC article.
Review.
Unravelling the networks dictating host resistance versus tolerance during pulmonary infections.
Isabelle Meunier, Eva Kaufmann, Jeffrey Downey, Maziar Divangahi.
Cell Tissue Res, 2017 Feb 09; 367(3). PMID: 28168323    Free PMC article.
Review.
Immune Cell-Epithelial/Mesenchymal Interaction Contributing to Allergic Airway Inflammation Associated Pathology.
Kiyoshi Hirahara, Kenta Shinoda, +5 authors, Toshinori Nakayama.
Front Immunol, 2019 Apr 12; 10. PMID: 30972065    Free PMC article.
Review.
The Role of T Cells in Herpes Stromal Keratitis.
Naveen K Rajasagi, Barry T Rouse.
Front Immunol, 2019 Apr 04; 10. PMID: 30941142    Free PMC article.
Review.
Deciphering the Roles of Innate Lymphoid Cells in Cancer.
Melanie Bruchard, Francois Ghiringhelli.
Front Immunol, 2019 Apr 27; 10. PMID: 31024531    Free PMC article.
Highly Cited. Review.
IL-33 Mediated Inflammation in Chronic Respiratory Diseases-Understanding the Role of the Member of IL-1 Superfamily.
Agata Gabryelska, Piotr Kuna, +2 authors, Michał Panek.
Front Immunol, 2019 May 07; 10. PMID: 31057533    Free PMC article.
Review.
An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease.
Liang Shao, Shan Pan, +9 authors, Albert K W Lie.
Front Immunol, 2019 Jun 28; 10. PMID: 31244831    Free PMC article.
Review.
Reparative T lymphocytes in organ injury.
Franco R D'Alessio, Johanna T Kurzhagen, Hamid Rabb.
J Clin Invest, 2019 Jul 02; 129(7). PMID: 31259743    Free PMC article.
Review.
Metabolites released from apoptotic cells act as tissue messengers.
Christopher B Medina, Parul Mehrotra, +9 authors, Kodi S Ravichandran.
Nature, 2020 Apr 03; 580(7801). PMID: 32238926    Free PMC article.
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.
Dongsheng Shang, Danlin Sun, +5 authors, Zhigang Tu.
Aging Cell, 2020 Apr 24; 19(5). PMID: 32323422    Free PMC article.
Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.
Ian C Boothby, Jarish N Cohen, Michael D Rosenblum.
Sci Immunol, 2020 May 03; 5(47). PMID: 32358172    Free PMC article.
Review.
Early-Life Respiratory Syncytial Virus Infection, Trained Immunity and Subsequent Pulmonary Diseases.
Carrie-Anne Malinczak, Nicholas W Lukacs, Wendy Fonseca.
Viruses, 2020 May 08; 12(5). PMID: 32375305    Free PMC article.
Review.
Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma.
Yu-Wen Huang, Chih-Yang Lin, +9 authors, Chih-Hsin Tang.
Aging (Albany NY), 2020 May 20; 12(10). PMID: 32428872    Free PMC article.
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
Alma Zernecke, Holger Winkels, +16 authors, Klaus Ley.
Circ Res, 2020 Jul 17; 127(3). PMID: 32673538    Free PMC article.
Review.
Ambiguous roles and potential therapeutic strategies of innate lymphoid cells in different types of tumor.
Shijie Wang, Pin Wu, Yongyuan Chen, Ying Chai.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724393    Free PMC article.
Review.
Molecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis.
Harry D Dawson, Celine Chen, +6 authors, Joseph F Urban.
Sci Rep, 2020 Aug 01; 10(1). PMID: 32732949    Free PMC article.
The Heterogeneity, Origins, and Impact of Migratory iILC2 Cells in Anti-helminth Immunity.
Mindy M Miller, R Lee Reinhardt.
Front Immunol, 2020 Aug 15; 11. PMID: 32793230    Free PMC article.
Review.
The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing.
Kavya L Singampalli, Swathi Balaji, +6 authors, Sundeep G Keswani.
Front Cell Dev Biol, 2020 Aug 28; 8. PMID: 32850791    Free PMC article.
Review.
Tissue regulatory T cells.
Prudence PokWai Lui, Inchul Cho, Niwa Ali.
Immunology, 2020 May 29; 161(1). PMID: 32463116    Free PMC article.
Review.
IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner.
E C Halvorsen, S E Franks, +7 authors, K L Bennewith.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713780    Free PMC article.
The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia.
Brandon N VanderVeen, E Angela Murphy, James A Carson.
Front Physiol, 2020 Sep 29; 11. PMID: 32982782    Free PMC article.
Review.
LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation.
Muchaala Yeboah, Charys Papagregoriou, +18 authors, Ali Roghanian.
JCI Insight, 2020 Sep 02; 5(18). PMID: 32870822    Free PMC article.
Is There a Role for Basophils in Cancer?
Giancarlo Marone, John T Schroeder, +6 authors, Gilda Varricchi.
Front Immunol, 2020 Oct 06; 11. PMID: 33013885    Free PMC article.
Review.
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Linh T Bui, Nichelle I Winters, +19 authors, Human Cell Atlas Lung Biological Network.
bioRxiv, 2020 Oct 28;. PMID: 33106805    Free PMC article.
The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation.
Yuichi Akama, Naoko Satoh-Takayama, +5 authors, Motomu Shimaoka.
Diagnostics (Basel), 2020 Oct 16; 10(10). PMID: 33053762    Free PMC article.
Review.
Abundance of Non-Polarized Lung Macrophages with Poor Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).
Kentaro Akata, Kei Yamasaki, +8 authors, Stephan F van Eeden.
Biomedicines, 2020 Oct 15; 8(10). PMID: 33050042    Free PMC article.
The transition of M-CSF-derived human macrophages to a growth-promoting phenotype.
Kajal Hamidzadeh, Ashton T Belew, Najib M El-Sayed, David M Mosser.
Blood Adv, 2020 Nov 10; 4(21). PMID: 33166408    Free PMC article.
Neural Regulation of Interactions Between Group 2 Innate Lymphoid Cells and Pulmonary Immune Cells.
Weiwei Chen, Qiang Shu, Jie Fan.
Front Immunol, 2020 Nov 17; 11. PMID: 33193374    Free PMC article.
Review.
Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma.
Mahmood Yaseen Hachim, Noha Mousaad Elemam, +9 authors, Rifat Hamoudi.
Front Med (Lausanne), 2020 Nov 17; 7. PMID: 33195308    Free PMC article.
Whole Transcriptome Analysis of Myeloid Dendritic Cells Reveals Distinct Genetic Regulation in Patients with Allergies.
Kijeong Lee, Mi-Ryung Han, +2 authors, Tae Hoon Kim.
Int J Mol Sci, 2020 Nov 20; 21(22). PMID: 33207814    Free PMC article.
The Evaluation of AREG, MMP-2, CHI3L1, GFAP, and OPN Serum Combined Value in Astrocytic Glioma Patients' Diagnosis and Prognosis.
Rūta Urbanavičiūtė, Kęstutis Skauminas, Daina Skiriutė.
Brain Sci, 2020 Nov 25; 10(11). PMID: 33227903    Free PMC article.
Group 2 Innate Lymphoid Cells: A Double-Edged Sword in Cancer?
Enrico Maggi, Irene Veneziani, +2 authors, Francesco Annunziato.
Cancers (Basel), 2020 Nov 26; 12(11). PMID: 33233582    Free PMC article.
Review.
Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica.
Chunsheng Yang, Yang Yang, +4 authors, Guoqiang Chang.
Int J Mol Med, 2019 Jan 11; 43(3). PMID: 30628649    Free PMC article.
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Erminia Mariani, Gina Lisignoli, Rosa Maria Borzì, Lia Pulsatelli.
Int J Mol Sci, 2019 Feb 06; 20(3). PMID: 30717232    Free PMC article.
Highly Cited. Review.
Type 2 Innate Lymphoid Cells in Liver and Gut: From Current Knowledge to Future Perspectives.
Aaron Ochel, Gisa Tiegs, Katrin Neumann.
Int J Mol Sci, 2019 Apr 20; 20(8). PMID: 30999584    Free PMC article.
Review.
Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit.
Rama Shankar, Mara L Leimanis, +9 authors, Surender Rajasekaran.
EBioMedicine, 2020 Nov 29; 62. PMID: 33248372    Free PMC article.
Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis.
Samantha M Golomb, Ian H Guldner, +7 authors, Siyuan Zhang.
Cell Rep, 2020 Dec 03; 33(9). PMID: 33264626    Free PMC article.
Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice.
Shanshan Tang, Mingfeng Zhang, +7 authors, Defu Zeng.
Proc Natl Acad Sci U S A, 2020 Nov 25; 117(49). PMID: 33229527    Free PMC article.
Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn.
Dan Yan, Fei Yu, +8 authors, Chunyi Shao.
Invest Ophthalmol Vis Sci, 2020 Dec 17; 61(14). PMID: 33326018    Free PMC article.
Function of innate lymphoid cells in the immune-related disorders.
Tanja Dzopalić, Biljana Božić-Nedeljković, Vladimir Jurišić.
Hum Cell, 2019 May 13; 32(3). PMID: 31079327
Review.
Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection.
Allen F Ryan, Chanond A Nasamran, +4 authors, Arwa Kurabi.
Front Genet, 2020 May 01; 11. PMID: 32351546    Free PMC article.
In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals.
Seung Seob Son, Soohyun Hwang, +7 authors, Eun Young Lee.
Sci Rep, 2021 Jan 28; 11(1). PMID: 33500443    Free PMC article.
Amphiregulin Regulates Melanocytic Senescence.
Michaela Pommer, Silke Kuphal, Anja K Bosserhoff.
Cells, 2021 Feb 11; 10(2). PMID: 33562468    Free PMC article.
Macrophages in Lung Injury, Repair, and Fibrosis.
Peiyong Cheng, Shuangyan Li, Huaiyong Chen.
Cells, 2021 Mar 07; 10(2). PMID: 33670759    Free PMC article.
Review.
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Caspar Schiffers, Cheryl van de Wetering, +8 authors, Albert van der Vliet.
JCI Insight, 2020 Dec 11; 6(2). PMID: 33301419    Free PMC article.
Untangling Local Pro-Inflammatory, Reparative, and Regulatory Damage-Associated Molecular-Patterns (DAMPs) Pathways to Improve Transplant Outcomes.
Gaelen K Dwyer, Hēth R Turnquist.
Front Immunol, 2021 Mar 13; 12. PMID: 33708206    Free PMC article.
Review.
Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort.
Isabel Drake, George Hindy, +4 authors, Marju Orho-Melander.
Sci Rep, 2021 Mar 26; 11(1). PMID: 33762603    Free PMC article.
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy.
Vincenzo Salemme, Giorgia Centonze, +2 authors, Laura Conti.
Front Oncol, 2021 Mar 30; 11. PMID: 33777750    Free PMC article.
Review.
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract.
Tim Flerlage, David F Boyd, +2 authors, Stacey Schultz-Cherry.
Nat Rev Microbiol, 2021 Apr 08; 19(7). PMID: 33824495    Free PMC article.
Review.
The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration.
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic.
Int J Mol Sci, 2021 Apr 04; 22(5). PMID: 33804369    Free PMC article.
Review.
Insights Into Human Intrahepatic NK Cell Function From Single Cell RNA Sequencing Datasets.
Gráinne Jameson, Mark W Robinson.
Front Immunol, 2021 Apr 09; 12. PMID: 33828559    Free PMC article.
Review.
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.
Egle Kvedaraite, Laura Hertwig, +22 authors, Karolinska KI/K COVID-19 Study Group.
Proc Natl Acad Sci U S A, 2021 Jan 23; 118(6). PMID: 33479167    Free PMC article.
T resident helper cells promote humoral responses in the lung.
Nivedya Swarnalekha, David Schreiner, +7 authors, Carolyn G King.
Sci Immunol, 2021 Jan 10; 6(55). PMID: 33419790    Free PMC article.
IL-33-mediated Eosinophilia Protects against Acute Lung Injury.
Paulette A Krishack, Maile K Hollinger, +5 authors, Philip A Verhoef.
Am J Respir Cell Mol Biol, 2021 Feb 12; 64(5). PMID: 33571420    Free PMC article.
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Hani Harb, Mehdi Benamar, +30 authors, Talal A Chatila.
Immunity, 2021 Apr 30; 54(6). PMID: 33915108    Free PMC article.
Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury.
Ryota Sakai, Minako Ito, +9 authors, Akihiko Yoshimura.
Cell Mol Immunol, 2020 Sep 13; 18(5). PMID: 32917984    Free PMC article.
Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes.
Joshua R Cox, Sheena M Cruickshank, Amy E Saunders.
Front Immunol, 2021 May 04; 12. PMID: 33936115    Free PMC article.
Review.
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions.
Giuseppe Ercolano, Alejandra Gomez-Cadena, +14 authors, Camilla Jandus.
Nat Commun, 2021 May 07; 12(1). PMID: 33953160    Free PMC article.
Role of ILC2 in Viral-Induced Lung Pathogenesis.
Wendy Fonseca, Nicholas W Lukacs, Srikanth Elesela, Carrie-Anne Malinczak.
Front Immunol, 2021 May 07; 12. PMID: 33953732    Free PMC article.
Review.
Critical role of interferons in gastrointestinal injury repair.
Constance McElrath, Vanessa Espinosa, +15 authors, Sergei V Kotenko.
Nat Commun, 2021 May 13; 12(1). PMID: 33976143    Free PMC article.
Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.
Liangxing Guo, Zhaokun Mu, +7 authors, Mengyun Li.
Sci Rep, 2021 May 15; 11(1). PMID: 33986327    Free PMC article.
Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing.
Chen Hu, Chenyu Chu, +7 authors, Yi Man.
Sci Adv, 2021 May 28; 7(22). PMID: 34039601    Free PMC article.
Review.
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma.
Nicolas Jacquelot, Cyril Seillet, +34 authors, Gabrielle T Belz.
Nat Immunol, 2021 Jun 09; 22(7). PMID: 34099918    Free PMC article.
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Moshit Lindzen, Soma Ghosh, +13 authors, Yosef Yarden.
Oncogene, 2021 May 05; 40(21). PMID: 33941851    Free PMC article.
Sex hormone regulation of innate lymphoid cells.
Eve Blanquart, Sophie Laffont, Jean-Charles Guéry.
Biomed J, 2021 Apr 24; 44(2). PMID: 33888441    Free PMC article.
Review.
Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment.
Ran Ran, Haoqing Yang, +3 authors, Ying Zheng.
BMC Oral Health, 2021 Jun 23; 21(1). PMID: 34154572    Free PMC article.
Acute Effects on the Human Peripheral Blood Transcriptome of Decompression Sickness Secondary to Scuba Diving.
Kurt Magri, Ingrid Eftedal, +4 authors, Nikolai Paul Pace.
Front Physiol, 2021 Jun 29; 12. PMID: 34177613    Free PMC article.
Identification of Monocytes Associated with Severe COVID-19 in the PBMCs of Severely Infected patients Through Single-Cell Transcriptome Sequencing.
Yan Zhang, Shuting Wang, +9 authors, Lanjuan Li.
Engineering (Beijing), 2021 Jun 22;. PMID: 34150352    Free PMC article.
The Janus Face of IL-33 Signaling in Tumor Development and Immune Escape.
Mi-Ran Choi, Jeffrey A Sosman, Bin Zhang.
Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34209038    Free PMC article.
Review.
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Linh T Bui, Nichelle I Winters, +19 authors, Human Cell Atlas Lung Biological Network.
Nat Commun, 2021 Jul 16; 12(1). PMID: 34262047    Free PMC article.
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Zheng Fu, Joseph W Dean, +6 authors, Liang Zhou.
Nat Commun, 2021 Jul 24; 12(1). PMID: 34294718    Free PMC article.
Nanoencapsulated Doxorubicin Prevents Mucositis Development in Mice.
Cristiane M Pinto, Laila S Horta, +7 authors, Gisele A C Goulart.
Pharmaceutics, 2021 Aug 11; 13(7). PMID: 34371713    Free PMC article.
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy.
Laura A Huppert, Michael D Green, +4 authors, James C Lee.
Cell Mol Immunol, 2021 Aug 22; 19(1). PMID: 34417572    Free PMC article.
Review.
Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia.
Alex R Schuurman, Tom DY Reijnders, +9 authors, Tom van der Poll.
Elife, 2021 Aug 24; 10. PMID: 34424199    Free PMC article.
Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection.
N Bhaskaran, E Schneider, +9 authors, P Pandiyan.
Nat Commun, 2021 Aug 28; 12(1). PMID: 34446704    Free PMC article.
Serum Amphiregulin and Heparin-Binding Epidermal Growth Factor as Biomarkers in Patients with Idiopathic Inflammatory Myopathy.
Norio Hanata, Yasuo Nagafuchi, +5 authors, Keishi Fujio.
J Clin Med, 2021 Aug 28; 10(16). PMID: 34442026    Free PMC article.
Interactions between islets and regulatory immune cells in health and type 1 diabetes.
Matthew A Budd, Mahdis Monajemi, +3 authors, Megan K Levings.
Diabetologia, 2021 Sep 23; 64(11). PMID: 34550422
Review.
C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived Macrophages.
Jacquelyn C Serfecz, Afsoon Saadin, +4 authors, Ricardo A Feldman.
Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34576075    Free PMC article.
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease.
Sheila K Pierson, Sushila Shenoy, +22 authors, David C Fajgenbaum.
Blood Adv, 2021 Aug 27; 5(17). PMID: 34438448    Free PMC article.
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.
Florian Klemm, Roeltje R Maas, +11 authors, Johanna A Joyce.
Cell, 2020 May 30; 181(7). PMID: 32470396    Free PMC article.
Interleukin-2 and regulatory T cells in rheumatic diseases.
Antonios G A Kolios, George C Tsokos, David Klatzmann.
Nat Rev Rheumatol, 2021 Nov 04; 17(12). PMID: 34728817
Review.
Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells.
Shang Chen, Haoyan Huang, +10 authors, Zongjin Li.
iScience, 2021 Nov 09; 24(11). PMID: 34746706    Free PMC article.
Tissue-Specific Molecular Markers and Heterogeneity in Type 2 Innate Lymphoid Cells.
Enrique Olguín-Martínez, Blanca E Ruiz-Medina, Paula Licona-Limón.
Front Immunol, 2021 Nov 12; 12. PMID: 34759931    Free PMC article.
Review.
Type 2 immunity in intestinal homeostasis and inflammatory bowel disease.
Xinxin Luo, Eduardo J Villablanca.
Biochem Soc Trans, 2021 Sep 29; 49(5). PMID: 34581755    Free PMC article.
Review.
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice.
Ming Zhao, Yingyao Quan, +10 authors, Chu-Xia Deng.
Int J Biol Sci, 2021 Nov 23; 17(15). PMID: 34803491    Free PMC article.
Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin.
Salvatore J Coniglio, Jeffrey E Segall.
PLoS One, 2021 Nov 30; 16(11). PMID: 34843542    Free PMC article.
Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling.
Joel Zindel, Jonas Mittner, +13 authors, Daniel Candinas.
Nat Commun, 2021 Dec 18; 12(1). PMID: 34916513    Free PMC article.
Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease.
Satoshi Kubo, Jill M Fritz, +31 authors, Michael J Lenardo.
Nat Immunol, 2021 Dec 24; 23(1). PMID: 34937930
Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.
Christopher M Dustin, Aida Habibovic, +8 authors, Albert van der Vliet.
J Immunol, 2021 Jun 06; 206(12). PMID: 34088769    Free PMC article.
Disease Tolerance during Viral-Bacterial Co-Infections.
Tarani Kanta Barman, Dennis W Metzger.
Viruses, 2021 Dec 29; 13(12). PMID: 34960631    Free PMC article.
Review.
IL-33, an Alarmin of the IL-1 Family Involved in Allergic and Non Allergic Inflammation: Focus on the Mechanisms of Regulation of Its Activity.
Corinne Cayrol.
Cells, 2022 Jan 12; 11(1). PMID: 35011670    Free PMC article.
Review.
Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD.
Danny W Bruce, Oleg Kolupaev, +5 authors, Jonathan S Serody.
Blood Adv, 2021 Oct 08; 5(22). PMID: 34619767    Free PMC article.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
Avraham Unterman, Tomokazu S Sumida, +46 authors, Charles S Dela Cruz.
Nat Commun, 2022 Jan 23; 13(1). PMID: 35064122    Free PMC article.
Cytokine Elevation in Severe COVID-19 From Longitudinal Proteomics Analysis: Comparison With Sepsis.
Takeshi Ebihara, Hisatake Matsumoto, +9 authors, Hiroshi Ogura.
Front Immunol, 2022 Feb 01; 12. PMID: 35095877    Free PMC article.
Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair.
Kelly Walton, Kirsti Walker, +19 authors, Brian C Betts.
Am J Transplant, 2021 Oct 21; 22(3). PMID: 34668635    Free PMC article.
Involvement of IL-33 in the Pathophysiology of Systemic Lupus Erythematosus: Review.
Julie Sarrand, Muhammad Soyfoo.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328556    Free PMC article.
Review.
The Discovery, Validation, and Function of Hypoxia-Related Gene Biomarkers for Obstructive Sleep Apnea.
Xiaofeng Wu, Zhou Pan, +4 authors, Ke Hu.
Front Med (Lausanne), 2022 Apr 05; 9. PMID: 35372438    Free PMC article.
Tissue remodeling by an opportunistic pathogen triggers allergic inflammation.
Karen Agaronyan, Lokesh Sharma, +8 authors, Ruslan Medzhitov.
Immunity, 2022 Apr 29; 55(5). PMID: 35483356    Free PMC article.
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity.
Jihye Han, Qingqing Wan, +5 authors, Yun-Cai Liu.
J Exp Med, 2022 May 10; 219(6). PMID: 35532553    Free PMC article.