Journal Article
. 2015 Feb;3().
doi: 10.1186/2193-1801-3-727.

Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women

Kristin Anderson 1 Patricia A Thompson 2 Betsy C Wertheim 2 Lorena Martin 3 Ian K Komenaka 4 Melissa Bondy 5 Adrian Daneri-Navarro 6 Maria Mercedes Meza-Montenegro 7 Luis Enrique Gutierrez-Millan 8 Abenaa Brewster 9 Lisa Madlensky 10 Malaika Tobias 1 Loki Natarajan 10 María Elena Martínez 10 
Affiliations
  • PMID: 25713754
  •     52 References
  •     4 citations

Abstract

Familial breast and ovarian cancer prevalence was assessed among 1150 women of Mexican descent enrolled in a case-only, binational breast cancer study. Logistic regression was conducted to compare odds of triple negative breast cancer (TNBC) to non-TNBC according to family history of breast and breast or ovarian cancer among 914 of these women. Prevalence of breast cancer family history in a first- and first- or second-degree relative was 13.1% and 24.1%, respectively; that for breast or ovarian cancer in a first-degree relative was 14.9%. After adjustment for age and country of residence, women with a first-degree relative with breast cancer were more likely to be diagnosed with TNBC than non-TNBC (OR=1.98; 95% CI, 1.26-3.11). The odds of TNBC compared to non-TNBC were 1.93 (95% CI, 1.26-2.97) for women with a first-degree relative with breast or ovarian cancer. There were non-significant stronger associations between family history and TNBC among women diagnosed at age <50 compared to ≥50 years for breast cancer in a first-degree relative (P-interaction = 0.14) and a first- or second-degree relative (P-interaction = 0.07). Findings suggest that familial breast cancers are associated with triple negative subtype, possibly related to BRCA mutations in Hispanic/Latina women, which are strongly associated with TNBC. Family history is an important tool to identify Hispanic/Latina women who may be at increased risk of TNBC, and could benefit from prevention and early detection strategies.

Keywords: Family history; Hispanic; Risk factor heterogeneity; Triple negative breast cancer.

Reproductive factors and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women.
Masaaki Kawai, Yoichiro Kakugawa, +3 authors, Yuko Minami.
Cancer Sci, 2012 Jul 06; 103(10). PMID: 22762156    Free PMC article.
Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network.
Jeffrey N Weitzel, Jessica Clague, +16 authors, Garrett P Larson.
J Clin Oncol, 2012 Dec 13; 31(2). PMID: 23233716    Free PMC article.
Breast cancer risk factors according to joint estrogen receptor and progesterone receptor status.
Jennifer A Rusiecki, Theodore R Holford, Shelia H Zahm, Tongzhang Zheng.
Cancer Detect Prev, 2005 Sep 28; 29(5). PMID: 16185815
Reproductive factors, heterogeneity, and breast tumor subtypes in women of mexican descent.
Maria Elena Martinez, Betsy C Wertheim, +8 authors, Patricia A Thompson.
Cancer Epidemiol Biomarkers Prev, 2013 Aug 21; 22(10). PMID: 23950213    Free PMC article.
Evaluation of the family history collection process and the accuracy of cancer reporting among a series of women with endometrial cancer.
Jennifer Ivanovich, Sheri Babb, +4 authors, Alison Whelan.
Clin Cancer Res, 2002 Jun 13; 8(6). PMID: 12060627
Adjuvant trastuzumab in HER2-positive breast cancer.
Dennis Slamon, Wolfgang Eiermann, +21 authors, Breast Cancer International Research Group.
N Engl J Med, 2011 Oct 14; 365(14). PMID: 21991949    Free PMC article.
Highly Cited.
Risk of breast cancer classified by joint estrogen receptor and progesterone receptor status among women 20-44 years of age.
Julie A Britton, Marilie D Gammon, +8 authors, Louise A Brinton.
Am J Epidemiol, 2002 Sep 13; 156(6). PMID: 12225998
Differences in estrogen receptor subtype according to family history of breast cancer among Hispanic, but not non-Hispanic White women.
Lisa M Hines, Betsy Risendal, +3 authors, Tim Byers.
Cancer Epidemiol Biomarkers Prev, 2008 Oct 10; 17(10). PMID: 18843012    Free PMC article.
The diverse distribution of risk factors between breast cancer subtypes of ER, PR and HER2: a 10-year retrospective multi-center study in China.
Qingkun Song, Rong Huang, +10 authors, Youlin Qiao.
PLoS One, 2013 Aug 27; 8(8). PMID: 23977244    Free PMC article.
Molecular portraits of human breast tumours.
C M Perou, T Sørlie, +15 authors, D Botstein.
Nature, 2000 Aug 30; 406(6797). PMID: 10963602
Highly Cited.
American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.
Karen H Lu, Marie E Wood, +15 authors, American Society of Clinical Oncology.
J Clin Oncol, 2014 Feb 05; 32(8). PMID: 24493721    Free PMC article.
Population-based estimates of the relation between breast cancer risk, tumor subtype, and family history.
Megan L Welsh, Diana S M Buist, +3 authors, Christopher I Li.
Breast Cancer Res Treat, 2008 Apr 26; 114(3). PMID: 18437558    Free PMC article.
Significant clinical impact of recurrent BRCA1 and BRCA2 mutations in Mexico.
Cynthia Villarreal-Garza, Rosa María Alvarez-Gómez, +10 authors, Jeffrey N Weitzel.
Cancer, 2014 Sep 23; 121(3). PMID: 25236687    Free PMC article.
What can we learn about disease etiology from case-case analyses? Lessons from breast cancer.
María Elena Martínez, Giovanna I Cruz, +2 authors, Patricia A Thompson.
Cancer Epidemiol Biomarkers Prev, 2010 Sep 28; 19(11). PMID: 20870734    Free PMC article.
Review.
Reproductive risk factors and breast cancer subtypes: a review of the literature.
Kristin N Anderson, Richard B Schwab, Maria Elena Martinez.
Breast Cancer Res Treat, 2014 Jan 31; 144(1). PMID: 24477977    Free PMC article.
Highly Cited. Review.
Coherence and completeness of population-based family cancer reports.
Louise Wideroff, Anne O Garceau, +7 authors, Barry I Graubard.
Cancer Epidemiol Biomarkers Prev, 2010 Feb 18; 19(3). PMID: 20160272    Free PMC article.
Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease.
Collaborative Group on Hormonal Factors in Breast Cancer.
Lancet, 2001 Nov 14; 358(9291). PMID: 11705483
Highly Cited. Review.
Family history and breast cancer hormone receptor status in a Spanish cohort.
Xuejuan Jiang, Jose Esteban Castelao, +13 authors, Manuela Gago-Dominguez.
PLoS One, 2012 Jan 13; 7(1). PMID: 22238615    Free PMC article.
Hormone-related factors and risk of breast cancer in relation to estrogen receptor and progesterone receptor status.
W Y Huang, B Newman, +3 authors, P G Moorman.
Am J Epidemiol, 2001 Feb 07; 151(7). PMID: 10752798
Reproductive and hormonal factors, family history, and breast cancer according to the hormonal receptor status.
Valentina Rosato, Cristina Bosetti, +6 authors, Carlo La Vecchia.
Eur J Cancer Prev, 2013 Jul 03; 23(5). PMID: 23817433
If we build it ... will they come?--establishing a cancer genetics services clinic for an underserved predominantly Latina cohort.
Charité Ricker, Veronica Lagos, +9 authors, Jeffrey Weitzel.
J Genet Couns, 2006 Nov 16; 15(6). PMID: 17106633
Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25.
Laura Fejerman, Nasim Ahmadiyeh, +24 authors, Elad Ziv.
Nat Commun, 2014 Oct 21; 5. PMID: 25327703    Free PMC article.
Highly Cited.
Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history.
Harvey J Murff, David R Spigel, Sapna Syngal.
JAMA, 2004 Sep 24; 292(12). PMID: 15383520
Highly Cited. Review.
Breast cancer risk factors defined by estrogen and progesterone receptor status: the multiethnic cohort study.
Veronica Wendy Setiawan, Kristine R Monroe, +3 authors, Brian E Henderson.
Am J Epidemiol, 2009 Mar 26; 169(10). PMID: 19318616    Free PMC article.
Progesterone and estrogen receptors and mammary neoplasia in the Iowa Women's Health Study: how many kinds of breast cancer are there?
J D Potter, J R Cerhan, +4 authors, A R Folsom.
Cancer Epidemiol Biomarkers Prev, 1995 Jun 01; 4(4). PMID: 7655325
Differences in risk factors for breast cancer molecular subtypes in a population-based study.
Xiaohong R Yang, Mark E Sherman, +15 authors, Montserrat García-Closas.
Cancer Epidemiol Biomarkers Prev, 2007 Mar 21; 16(3). PMID: 17372238
Highly Cited.
Risk factors for triple-negative breast cancer in women under the age of 45 years.
Jessica M Dolle, Janet R Daling, +4 authors, Kathleen E Malone.
Cancer Epidemiol Biomarkers Prev, 2009 Apr 02; 18(4). PMID: 19336554    Free PMC article.
Familial breast cancer in southern Finland: how prevalent are breast cancer families and can we trust the family history reported by patients?
H Eerola, C Blomqvist, +2 authors, H Nevanlinna.
Eur J Cancer, 2000 Jun 16; 36(9). PMID: 10854948
Family history of cancer: is it an accurate indicator of cancer risk in the immigrant population?
Heather Orom, Michele L Coté, +2 authors, Ann G Schwartz.
Cancer, 2007 Dec 12; 112(2). PMID: 18072272
Risk factors for estrogen receptor-rich and estrogen receptor-poor breast cancers.
A McTiernan, D B Thomas, L K Johnson, D Roseman.
J Natl Cancer Inst, 1986 Oct 01; 77(4). PMID: 3463818
Association of hormone-related characteristics and breast cancer risk by estrogen receptor/progesterone receptor status in the shanghai breast cancer study.
Ping-Ping Bao, Xiao Ou Shu, +8 authors, Wei Zheng.
Am J Epidemiol, 2011 Jul 20; 174(6). PMID: 21768404    Free PMC article.
Evidence for common ancestral origin of a recurring BRCA1 genomic rearrangement identified in high-risk Hispanic families.
Jeffrey N Weitzel, Veronica I Lagos, +8 authors, Tom Scholl.
Cancer Epidemiol Biomarkers Prev, 2007 Jul 25; 16(8). PMID: 17646271
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
Limited family structure and BRCA gene mutation status in single cases of breast cancer.
Jeffrey N Weitzel, Veronica I Lagos, +6 authors, Deborah J MacDonald.
JAMA, 2007 Jun 21; 297(23). PMID: 17579227
Risk factors for breast cancer according to estrogen and progesterone receptor status.
Graham A Colditz, Bernard A Rosner, +2 authors, Susan E Hankinson.
J Natl Cancer Inst, 2004 Feb 05; 96(3). PMID: 14759989
Highly Cited.
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies.
Xiaohong R Yang, Jenny Chang-Claude, +171 authors, Montserrat Garcia-Closas.
J Natl Cancer Inst, 2010 Dec 31; 103(3). PMID: 21191117    Free PMC article.
Highly Cited.
Social-cognitive aspects of underserved Latinas preparing to undergo genetic cancer risk assessment for hereditary breast and ovarian cancer.
Veronica I Lagos, Martin A Perez, +5 authors, Jeffrey N Weitzel.
Psychooncology, 2008 Jul 23; 17(8). PMID: 18646245
Confirmation of family cancer history reported in a population-based survey.
Phuong L Mai, Anne O Garceau, +7 authors, Louise Wideroff.
J Natl Cancer Inst, 2011 May 13; 103(10). PMID: 21562245    Free PMC article.
Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study.
Yinghao Su, Ying Zheng, +6 authors, Xiao Ou Shu.
BMC Cancer, 2011 Jul 14; 11. PMID: 21749714    Free PMC article.
Breast cancer risk factors according to combined estrogen and progesterone receptor status: a case-control analysis.
K Y Yoo, K Tajima, +4 authors, R Dubrow.
Am J Epidemiol, 1997 Aug 15; 146(4). PMID: 9270409
Family history of breast cancer in first-degree relatives and triple-negative breast cancer risk.
Amanda I Phipps, Diana S M Buist, +4 authors, Christopher I Li.
Breast Cancer Res Treat, 2010 Sep 04; 126(3). PMID: 20814817    Free PMC article.
Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
Nasim Mavaddat, Paul D Pharoah, +8 authors, Antonis C Antoniou.
Breast Cancer Res, 2010 Feb 12; 12(1). PMID: 20146796    Free PMC article.
Association between family history of cancer and breast cancer defined by estrogen and progesterone receptor status.
A M Tutera, T A Sellers, +3 authors, A R Folsom.
Genet Epidemiol, 1996 Jan 01; 13(2). PMID: 8722747
Epidemiology of basal-like breast cancer.
Robert C Millikan, Beth Newman, +13 authors, Charles M Perou.
Breast Cancer Res Treat, 2007 Jun 21; 109(1). PMID: 17578664    Free PMC article.
Highly Cited.
Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroup.
Michelle Cotterchio, Nancy Kreiger, +2 authors, Saira Bahl.
Cancer Epidemiol Biomarkers Prev, 2003 Oct 28; 12(10). PMID: 14578142
Risk factors for breast cancer in young women by oestrogen receptor and progesterone receptor status.
M R E McCredie, G S Dite, +3 authors, J L Hopper.
Br J Cancer, 2003 Oct 30; 89(9). PMID: 14583766    Free PMC article.
Risk factors for hormone receptor-defined breast cancer in postmenopausal women.
Lena U Rosenberg, Kristjana Einarsdóttir, +4 authors, Cecilia Magnusson.
Cancer Epidemiol Biomarkers Prev, 2006 Dec 14; 15(12). PMID: 17164374
A case-control study of breast cancer stratified by estrogen receptor status.
J L Stanford, M Szklo, +4 authors, R N Hoover.
Am J Epidemiol, 1987 Feb 01; 125(2). PMID: 3812427
Family history, and impact on clinical presentation and prognosis, in a population-based breast cancer cohort from the Stockholm County.
Sara Margolin, Hemming Johansson, +2 authors, Tommy Fornander.
Fam Cancer, 2006 Jul 22; 5(4). PMID: 16858627
Pathological and molecular diagnosis of triple-negative breast cancer: a clinical perspective.
F Penault-Llorca, G Viale.
Ann Oncol, 2012 Oct 04; 23 Suppl 6. PMID: 23012297
Review.
Migration history, acculturation, and breast cancer risk in Hispanic women.
Esther M John, Amanda I Phipps, Adam Davis, Jocelyn Koo.
Cancer Epidemiol Biomarkers Prev, 2005 Dec 21; 14(12). PMID: 16365008
Highly Cited.
Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis.
Mariaelena Pierobon, Cara L Frankenfeld.
Breast Cancer Res Treat, 2012 Nov 28; 137(1). PMID: 23179600
Highly Cited. Systematic Review.
Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium.
Emma H Allott, Stephanie M Cohen, +19 authors, Melissa A Troester.
Cancer Epidemiol Biomarkers Prev, 2015 Dec 30; 25(3). PMID: 26711328    Free PMC article.
Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women.
Traci N Bethea, Lynn Rosenberg, +9 authors, Julie R Palmer.
Cancer Epidemiol Biomarkers Prev, 2016 Jan 02; 25(2). PMID: 26721669    Free PMC article.
Germline Mutations in Triple-Negative Breast Cancer.
Eric Hahnen, Jan Hauke, +3 authors, Rita K Schmutzler.
Breast Care (Basel), 2017 Jun 15; 12(1). PMID: 28611536    Free PMC article.
Review.
Triple-negative breast cancer in Peru: 2000 patients and 15 years of experience.
Gabriel De-la-Cruz-Ku, Marianne Luyo, +19 authors, Bryan Valcarcel.
PLoS One, 2020 Aug 25; 15(8). PMID: 32833983    Free PMC article.