Journal Article
. 2015 Mar;114(3).
doi: 10.1016/j.radonc.2015.02.015.

CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma

Thibaud P Coroller 1 Patrick Grossmann 2 Ying Hou 3 Emmanuel Rios Velazquez 3 Ralph T H Leijenaar 4 Gretchen Hermann 3 Philippe Lambin 4 Benjamin Haibe-Kains 5 Raymond H Mak 3 Hugo J W L Aerts 6 
  • PMID: 25746350
  •     35 References
  •     207 citations


Background And Purpose: Radiomics provides opportunities to quantify the tumor phenotype non-invasively by applying a large number of quantitative imaging features. This study evaluates computed-tomography (CT) radiomic features for their capability to predict distant metastasis (DM) for lung adenocarcinoma patients.

Material And Methods: We included two datasets: 98 patients for discovery and 84 for validation. The phenotype of the primary tumor was quantified on pre-treatment CT-scans using 635 radiomic features. Univariate and multivariate analysis was performed to evaluate radiomics performance using the concordance index (CI).

Results: Thirty-five radiomic features were found to be prognostic (CI>0.60, FDR<5%) for DM and twelve for survival. It is noteworthy that tumor volume was only moderately prognostic for DM (CI=0.55, p-value=2.77×10(-5)) in the discovery cohort. A radiomic-signature had strong power for predicting DM in the independent validation dataset (CI=0.61, p-value=1.79×10(-17)). Adding this radiomic-signature to a clinical model resulted in a significant improvement of predicting DM in the validation dataset (p-value=1.56×10(-11)).

Conclusions: Although only basic metrics are routinely quantified, this study shows that radiomic features capturing detailed information of the tumor phenotype can be used as a prognostic biomarker for clinically-relevant factors such as DM. Moreover, the radiomic-signature provided additional information to clinical data.

Keywords: Biomarkers; Distant metastasis; Lung adenocarcinoma; NSCLC; Quantitative imaging; Radiomics.

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J Med Imaging (Bellingham), 2017 Dec 30; 5(1). PMID: 29285518    Free PMC article.
Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL.
Adam Olshen, Denise Wolf, +10 authors, Catherine C Park.
J Med Imaging (Bellingham), 2018 Jan 04; 5(1). PMID: 29296631    Free PMC article.
Towards precision medicine: from quantitative imaging to radiomics.
U Rajendra Acharya, Yuki Hagiwara, +2 authors, Kwan Hoong Ng.
J Zhejiang Univ Sci B, 2018 Jan 09; 19(1). PMID: 29308604    Free PMC article.
Can CT-based radiomics signature predict KRAS/NRAS/BRAF mutations in colorectal cancer?
Lei Yang, Di Dong, +7 authors, Jie Tian.
Eur Radiol, 2018 Jan 18; 28(5). PMID: 29335867
Highly Cited.
Effect of tube current on computed tomography radiomic features.
Dennis Mackin, Rachel Ger, +8 authors, Laurence Court.
Sci Rep, 2018 Feb 07; 8(1). PMID: 29403060    Free PMC article.
Pre-treatment magnetic resonance-based texture features as potential imaging biomarkers for predicting event free survival in anal cancer treated by chemoradiotherapy.
Arnaud Hocquelet, Thibaut Auriac, +7 authors, Véronique Vendrely.
Eur Radiol, 2018 Feb 07; 28(7). PMID: 29404766
Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study.
Ralph Th Leijenaar, Marta Bogowicz, +14 authors, Philippe Lambin.
Br J Radiol, 2018 Feb 17; 91(1086). PMID: 29451412    Free PMC article.
18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC) - A prospective externally validated study.
Sara Carvalho, Ralph T H Leijenaar, +6 authors, Philippe Lambin.
PLoS One, 2018 Mar 02; 13(3). PMID: 29494598    Free PMC article.
The crucial role of multiomic approach in cancer research and clinically relevant outcomes.
Miaolong Lu, Xianquan Zhan.
EPMA J, 2018 Mar 09; 9(1). PMID: 29515689    Free PMC article.
Highly Cited. Review.
Data Analysis Strategies in Medical Imaging.
Chintan Parmar, Joseph D Barry, +2 authors, Hugo J W L Aerts.
Clin Cancer Res, 2018 Mar 28; 24(15). PMID: 29581134    Free PMC article.
Identification of high-risk plaque features in intracranial atherosclerosis: initial experience using a radiomic approach.
Zhang Shi, Chengcheng Zhu, +10 authors, Qi Liu.
Eur Radiol, 2018 Apr 11; 28(9). PMID: 29633002    Free PMC article.
Artificial intelligence in radiology.
Ahmed Hosny, Chintan Parmar, +2 authors, Hugo J W L Aerts.
Nat Rev Cancer, 2018 May 20; 18(8). PMID: 29777175    Free PMC article.
Highly Cited. Review.
The predictive value of CT-based radiomics in differentiating indolent from invasive lung adenocarcinoma in patients with pulmonary nodules.
Yunlang She, Lei Zhang, +9 authors, Chang Chen.
Eur Radiol, 2018 Jun 06; 28(12). PMID: 29869172
Radiomics for Response and Outcome Assessment for Non-Small Cell Lung Cancer.
Liting Shi, Yaoyao He, +4 authors, Yi Rong.
Technol Cancer Res Treat, 2018 Jun 27; 17. PMID: 29940810    Free PMC article.
Voxel size and gray level normalization of CT radiomic features in lung cancer.
Muhammad Shafiq-Ul-Hassan, Kujtim Latifi, +3 authors, Eduardo Moros.
Sci Rep, 2018 Jul 14; 8(1). PMID: 30002441    Free PMC article.
Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis.
Shih-Ying Huang, Benjamin L Franc, +11 authors, Youngho Seo.
NPJ Breast Cancer, 2018 Aug 23; 4. PMID: 30131973    Free PMC article.
Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings.
Gregory Penzias, Asha Singanamalli, +13 authors, Anant Madabhushi.
PLoS One, 2018 Sep 01; 13(8). PMID: 30169514    Free PMC article.
Texture features and pharmacokinetic parameters in differentiating benign and malignant breast lesions by dynamic contrast enhanced magnetic resonance imaging.
Qingliang Niu, Xiaomei Jiang, +4 authors, Xuexi Zhang.
Oncol Lett, 2018 Sep 15; 16(4). PMID: 30214595    Free PMC article.
Radiomics signature of computed tomography imaging for prediction of survival and chemotherapeutic benefits in gastric cancer.
Yuming Jiang, Chuanli Chen, +10 authors, Guoxin Li.
EBioMedicine, 2018 Sep 19; 36. PMID: 30224313    Free PMC article.
A radiogenomic dataset of non-small cell lung cancer.
Shaimaa Bakr, Olivier Gevaert, +14 authors, Sandy Napel.
Sci Data, 2018 Oct 17; 5. PMID: 30325352    Free PMC article.
Peritumoral radiomics features predict distant metastasis in locally advanced NSCLC.
Tai H Dou, Thibaud P Coroller, +2 authors, Hugo J W L Aerts.
PLoS One, 2018 Nov 06; 13(11). PMID: 30388114    Free PMC article.
Radiomics and liquid biopsy in oncology: the holons of systems medicine.
Emanuele Neri, Marzia Del Re, +4 authors, Romano Danesi.
Insights Imaging, 2018 Nov 16; 9(6). PMID: 30430428    Free PMC article.
Feasibility of CT radiomics to predict treatment response of individual liver metastases in esophagogastric cancer patients.
Remy Klaassen, Ruben T H M Larue, +4 authors, Hanneke W M van Laarhoven.
PLoS One, 2018 Nov 16; 13(11). PMID: 30440002    Free PMC article.
A radiomic approach for adaptive radiotherapy in non-small cell lung cancer patients.
Sara Ramella, Michele Fiore, +10 authors, Paolo Soda.
PLoS One, 2018 Nov 22; 13(11). PMID: 30462705    Free PMC article.
Unsupervised machine learning of radiomic features for predicting treatment response and overall survival of early stage non-small cell lung cancer patients treated with stereotactic body radiation therapy.
Hongming Li, Maya Galperin-Aizenberg, +2 authors, Yong Fan.
Radiother Oncol, 2018 Nov 27; 129(2). PMID: 30473058    Free PMC article.
Comparison of prediction models with radiological semantic features and radiomics in lung cancer diagnosis of the pulmonary nodules: a case-control study.
Wei Wu, Larry A Pierce, +8 authors, Paul E Kinahan.
Eur Radiol, 2019 May 23; 29(11). PMID: 31115618    Free PMC article.
Towards clinical application of image mining: a systematic review on artificial intelligence and radiomics.
Martina Sollini, Lidija Antunovic, Arturo Chiti, Margarita Kirienko.
Eur J Nucl Med Mol Imaging, 2019 Jun 20; 46(13). PMID: 31214791    Free PMC article.
Systematic Review.
AI-based applications in hybrid imaging: how to build smart and truly multi-parametric decision models for radiomics.
Isabella Castiglioni, Francesca Gallivanone, +5 authors, Marco Salvatore.
Eur J Nucl Med Mol Imaging, 2019 Jul 12; 46(13). PMID: 31292700
Radiomics and Texture Analysis in Laryngeal Cancer. Looking for New Frontiers in Precision Medicine through Imaging Analysis.
Carlos Miguel Chiesa-Estomba, Oier Echaniz, +3 authors, Manuel Graña.
Cancers (Basel), 2019 Sep 25; 11(10). PMID: 31547210    Free PMC article.
Radiomics-based predictive risk score: A scoring system for preoperatively predicting risk of lymph node metastasis in patients with resectable non-small cell lung cancer.
Lan He, Yanqi Huang, +3 authors, Zaiyi Liu.
Chin J Cancer Res, 2019 Oct 01; 31(4). PMID: 31564807    Free PMC article.
A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy.
Georgios Kaissis, Sebastian Ziegelmayer, +10 authors, Rickmer Braren.
PLoS One, 2019 Oct 03; 14(10). PMID: 31577805    Free PMC article.
A machine learning based delta-radiomics process for early prediction of treatment response of pancreatic cancer.
Haidy Nasief, Cheng Zheng, +4 authors, X Allen Li.
NPJ Precis Oncol, 2019 Oct 12; 3. PMID: 31602401    Free PMC article.
Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.
Olivier Morin, William C Chen, +22 authors, David R Raleigh.
Neurooncol Adv, 2019 Oct 15; 1(1). PMID: 31608329    Free PMC article.
Technical Note: Proof of concept for radiomics-based quality assurance for computed tomography.
Luciano R F Branco, Rachel B Ger, +3 authors, Rick R Layman.
J Appl Clin Med Phys, 2019 Oct 15; 20(11). PMID: 31609076    Free PMC article.
CT radiomic features for predicting resectability of oesophageal squamous cell carcinoma as given by feature analysis: a case control study.
Jing Ou, Rui Li, +11 authors, Jiani Hu.
Cancer Imaging, 2019 Oct 18; 19(1). PMID: 31619297    Free PMC article.
Distributed radiomics as a signature validation study using the Personal Health Train infrastructure.
Zhenwei Shi, Ivan Zhovannik, +9 authors, Leonard Wee.
Sci Data, 2019 Oct 24; 6(1). PMID: 31641134    Free PMC article.
Radiomics features on radiotherapy treatment planning CT can predict patient survival in locally advanced rectal cancer patients.
Jiazhou Wang, Lijun Shen, +6 authors, Zhen Zhang.
Sci Rep, 2019 Oct 28; 9(1). PMID: 31653909    Free PMC article.
Technical Note: Ontology-guided radiomics analysis workflow (O-RAW).
Zhenwei Shi, Alberto Traverso, +2 authors, Leonard Wee.
Med Phys, 2019 Oct 04; 46(12). PMID: 31580484    Free PMC article.
Establishment of a new non-invasive imaging prediction model for liver metastasis in colon cancer.
Yu Li, Aydin Eresen, +7 authors, Zhuoli Zhang.
Am J Cancer Res, 2019 Dec 10; 9(11). PMID: 31815048    Free PMC article.
Radiomics in stratification of pancreatic cystic lesions: Machine learning in action.
Vipin Dalal, Joseph Carmicheal, +3 authors, Surinder K Batra.
Cancer Lett, 2019 Oct 21; 469. PMID: 31629933    Free PMC article.
The effects of volume of interest delineation on MRI-based radiomics analysis: evaluation with two disease groups.
Xiao Zhang, Liming Zhong, +6 authors, Qianjin Feng.
Cancer Imaging, 2019 Dec 23; 19(1). PMID: 31864421    Free PMC article.
Quantitative MRI Biomarkers of Stereotactic Radiotherapy Outcome in Brain Metastasis.
Elham Karami, Hany Soliman, +9 authors, Ali Sadeghi-Naini.
Sci Rep, 2019 Dec 29; 9(1). PMID: 31882597    Free PMC article.
Application of radiomics signature captured from pretreatment thoracic CT to predict brain metastases in stage III/IV ALK-positive non-small cell lung cancer patients.
Xinyan Xu, Lyu Huang, +5 authors, Min Fan.
J Thorac Dis, 2020 Jan 07; 11(11). PMID: 31903240    Free PMC article.
CT-based radiomics for prediction of histologic subtype and metastatic disease in primary malignant lung neoplasms.
José Raniery Ferreira-Junior, Marcel Koenigkam-Santos, +6 authors, Paulo Mazzoncini de Azevedo-Marques.
Int J Comput Assist Radiol Surg, 2019 Nov 14; 15(1). PMID: 31722085
Impact of contouring variability on oncological PET radiomics features in the lung.
F Yang, G Simpson, +3 authors, L Wang.
Sci Rep, 2020 Jan 17; 10(1). PMID: 31941949    Free PMC article.
Improving Treatment Response Prediction for Chemoradiation Therapy of Pancreatic Cancer Using a Combination of Delta-Radiomics and the Clinical Biomarker CA19-9.
Haidy Nasief, William Hall, +4 authors, X Allen Li.
Front Oncol, 2020 Jan 24; 9. PMID: 31970088    Free PMC article.
Artificial intelligence, machine learning, computer-aided diagnosis, and radiomics: advances in imaging towards to precision medicine.
Marcel Koenigkam Santos, José Raniery Ferreira Júnior, +3 authors, Paulo Mazzoncini de Azevedo Marques.
Radiol Bras, 2020 Feb 13; 52(6). PMID: 32047333    Free PMC article.
Prediction of Radiation Pneumonitis With Dose Distribution: A Convolutional Neural Network (CNN) Based Model.
Bin Liang, Yuan Tian, +6 authors, Jianrong Dai.
Front Oncol, 2020 Feb 23; 9. PMID: 32076596    Free PMC article.
Prediction of Treatment Response to Neoadjuvant Chemotherapy for Breast Cancer via Early Changes in Tumor Heterogeneity Captured by DCE-MRI Registration.
Nariman Jahani, Eric Cohen, +6 authors, Despina Kontos.
Sci Rep, 2019 Aug 23; 9(1). PMID: 31431633    Free PMC article.
Objective risk stratification of prostate cancer using machine learning and radiomics applied to multiparametric magnetic resonance images.
Bino Varghese, Frank Chen, +8 authors, Gaurav Pandey.
Sci Rep, 2019 Feb 09; 9(1). PMID: 30733585    Free PMC article.
The complexity of tumor shape, spiculatedness, correlates with tumor radiomic shape features.
Elaine Johanna Limkin, Sylvain Reuzé, +6 authors, Charlotte Robert.
Sci Rep, 2019 Mar 15; 9(1). PMID: 30867443    Free PMC article.
Revealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness.
Dmitry Cherezov, Dmitry Goldgof, +4 authors, Adrien Depeursinge.
Sci Rep, 2019 Mar 16; 9(1). PMID: 30872600    Free PMC article.
The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective.
Robert H Press, Hui-Kuo G Shu, +23 authors, John M Buatti.
Int J Radiat Oncol Biol Phys, 2018 Jul 04; 102(4). PMID: 29966725    Free PMC article.
Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study.
Ahmed Hosny, Chintan Parmar, +7 authors, Hugo J W L Aerts.
PLoS Med, 2018 Dec 01; 15(11). PMID: 30500819    Free PMC article.
Highly Cited.
Perinodular and Intranodular Radiomic Features on Lung CT Images Distinguish Adenocarcinomas from Granulomas.
Niha Beig, Mohammadhadi Khorrami, +16 authors, Anant Madabhushi.
Radiology, 2018 Dec 19; 290(3). PMID: 30561278    Free PMC article.
Highly Cited.
Therapeutic decision based on molecular detection of resistance mechanism in an ALK-rearranged lung cancer patient: a case report.
Elisa De Carlo, Monica Schiappacassi, +8 authors, Alessandra Bearz.
Onco Targets Ther, 2018 Dec 24; 11. PMID: 30573982    Free PMC article.
Radiomic signature of 18F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits.
Yuming Jiang, Qingyu Yuan, +13 authors, Guoxin Li.
Theranostics, 2019 Jan 08; 8(21). PMID: 30613271    Free PMC article.
Radiomics Analysis of PET and CT Components of PET/CT Imaging Integrated with Clinical Parameters: Application to Prognosis for Nasopharyngeal Carcinoma.
Wenbing Lv, Qingyu Yuan, +5 authors, Lijun Lu.
Mol Imaging Biol, 2019 Jan 24; 21(5). PMID: 30671740
IDH mutation-specific radiomic signature in lower-grade gliomas.
Xing Liu, Yiming Li, +9 authors, Yinyan Wang.
Aging (Albany NY), 2019 Jan 31; 11(2). PMID: 30696801    Free PMC article.
NCTN Assessment on Current Applications of Radiomics in Oncology.
Ke Nie, Hania Al-Hallaq, +15 authors, Issam El Naqa.
Int J Radiat Oncol Biol Phys, 2019 Feb 04; 104(2). PMID: 30711529    Free PMC article.
Artificial intelligence in cancer imaging: Clinical challenges and applications.
Wenya Linda Bi, Ahmed Hosny, +16 authors, Hugo J W L Aerts.
CA Cancer J Clin, 2019 Feb 06; 69(2). PMID: 30720861    Free PMC article.
Highly Cited. Review.
RaCaT: An open source and easy to use radiomics calculator tool.
Elisabeth Pfaehler, Alex Zwanenburg, Johan R de Jong, Ronald Boellaard.
PLoS One, 2019 Feb 21; 14(2). PMID: 30785937    Free PMC article.
Deep learning in head & neck cancer outcome prediction.
André Diamant, Avishek Chatterjee, +2 authors, Jan Seuntjens.
Sci Rep, 2019 Feb 28; 9(1). PMID: 30809047    Free PMC article.
MRI-based Radiomics nomogram to detect primary rectal cancer with synchronous liver metastases.
Zhenyu Shu, Songhua Fang, +5 authors, Xiangyang Gong.
Sci Rep, 2019 Mar 06; 9(1). PMID: 30833648    Free PMC article.
The Applications of Radiomics in Precision Diagnosis and Treatment of Oncology: Opportunities and Challenges.
Zhenyu Liu, Shuo Wang, +8 authors, Jie Tian.
Theranostics, 2019 Mar 15; 9(5). PMID: 30867832    Free PMC article.
Highly Cited. Review.
Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging.
Yiwen Xu, Ahmed Hosny, +5 authors, Hugo J W L Aerts.
Clin Cancer Res, 2019 Apr 24; 25(11). PMID: 31010833    Free PMC article.
Highly Cited.
Longitudinal radiomics of cone-beam CT images from non-small cell lung cancer patients: Evaluation of the added prognostic value for overall survival and locoregional recurrence.
Janna E van Timmeren, Wouter van Elmpt, +11 authors, Philippe Lambin.
Radiother Oncol, 2019 Apr 25; 136. PMID: 31015133    Free PMC article.
Nf1 loss promotes Kras-driven lung adenocarcinoma and results in Psat1-mediated glutamate dependence.
Xiaojing Wang, Shengping Min, +10 authors, Yuqing Chen.
EMBO Mol Med, 2019 May 01; 11(6). PMID: 31036704    Free PMC article.
Radiomic feature stability across 4D respiratory phases and its impact on lung tumor prognosis prediction.
Qian Du, Michael Baine, +9 authors, Dandan Zheng.
PLoS One, 2019 May 08; 14(5). PMID: 31063500    Free PMC article.
Design and fabrication of heterogeneous lung nodule phantoms for assessing the accuracy and variability of measured texture radiomics features in CT.
Ehsan Samei, Jocelyn Hoye, +2 authors, Daniele Marin.
J Med Imaging (Bellingham), 2019 Jul 03; 6(2). PMID: 31263737    Free PMC article.
Segmentation and Classification in Digital Pathology for Glioma Research: Challenges and Deep Learning Approaches.
Tahsin Kurc, Spyridon Bakas, +21 authors, Keyvan Farahani.
Front Neurosci, 2020 Mar 11; 14. PMID: 32153349    Free PMC article.
Multiparametric radiomics methods for breast cancer tissue characterization using radiological imaging.
Vishwa S Parekh, Michael A Jacobs.
Breast Cancer Res Treat, 2020 Feb 06; 180(2). PMID: 32020435    Free PMC article.
Cardiac magnetic resonance radiomics: basic principles and clinical perspectives.
Zahra Raisi-Estabragh, Cristian Izquierdo, +5 authors, Steffen E Petersen.
Eur Heart J Cardiovasc Imaging, 2020 Mar 07; 21(4). PMID: 32142107    Free PMC article.
Systematic analysis of bias and variability of morphologic features for lung lesions in computed tomography.
Jocelyn Hoye, Justin Solomon, +2 authors, Ehsan Samei.
J Med Imaging (Bellingham), 2019 Apr 05; 6(1). PMID: 30944842    Free PMC article.
Radiomics signature: a biomarker for the preoperative discrimination of lung invasive adenocarcinoma manifesting as a ground-glass nodule.
Li Fan, MengJie Fang, +6 authors, ShiYuan Liu.
Eur Radiol, 2018 Jul 04; 29(2). PMID: 29967956
Predicting the grade of hepatocellular carcinoma based on non-contrast-enhanced MRI radiomics signature.
Minghui Wu, Hongna Tan, +7 authors, Dapeng Shi.
Eur Radiol, 2018 Nov 09; 29(6). PMID: 30406313
Preoperative radiomic signature based on multiparametric magnetic resonance imaging for noninvasive evaluation of biological characteristics in rectal cancer.
Xiaochun Meng, Wei Xia, +12 authors, Xin Gao.
Eur Radiol, 2018 Nov 11; 29(6). PMID: 30413959
Adaptive statistical iterative reconstruction (ASIR) affects CT radiomics quantification in primary colorectal cancer.
Davide Prezzi, Katarzyna Owczarczyk, +4 authors, Vicky Goh.
Eur Radiol, 2019 Mar 20; 29(10). PMID: 30887205    Free PMC article.
Cone-beam CT radiomics features might improve the prediction of lung toxicity after SBRT in stage I NSCLC patients.
Qingjin Qin, Anhui Shi, +7 authors, Ligang Xing.
Thorac Cancer, 2020 Feb 16; 11(4). PMID: 32061061    Free PMC article.
Radiomics robustness assessment and classification evaluation: A two-stage method demonstrated on multivendor FFDM.
Kayla Robinson, Hui Li, +2 authors, Maryellen Giger.
Med Phys, 2019 Feb 26; 46(5). PMID: 30802972    Free PMC article.
A radiomics approach based on support vector machine using MR images for preoperative lymph node status evaluation in intrahepatic cholangiocarcinoma.
Lei Xu, Pengfei Yang, +9 authors, Tianye Niu.
Theranostics, 2019 Aug 15; 9(18). PMID: 31410221    Free PMC article.
Predicting locally advanced rectal cancer response to neoadjuvant therapy with 18F-FDG PET and MRI radiomics features.
V Giannini, S Mazzetti, +11 authors, D Regge.
Eur J Nucl Med Mol Imaging, 2019 Jan 15; 46(4). PMID: 30637502
Integrative Radiogenomics Approach for Risk Assessment of Post-Operative Metastasis in Pathological T1 Renal Cell Carcinoma: A Pilot Retrospective Cohort Study.
Hye Won Lee, Hwan-Ho Cho, +9 authors, Hyunjin Park.
Cancers (Basel), 2020 Apr 08; 12(4). PMID: 32252440    Free PMC article.
Radiomics Analysis of MRI for Predicting Molecular Subtypes of Breast Cancer in Young Women.
Qinmei Li, James Dormer, +3 authors, Baowei Fei.
Proc SPIE Int Soc Opt Eng, 2019 Feb 01; 10950. PMID: 32528211    Free PMC article.
Multisite evaluation of radiomic feature reproducibility and discriminability for identifying peripheral zone prostate tumors on MRI.
Prathyush Chirra, Patrick Leo, +6 authors, Satish E Viswanath.
J Med Imaging (Bellingham), 2019 Jul 02; 6(2). PMID: 31259199    Free PMC article.
Radiomics Prediction of EGFR Status in Lung Cancer-Our Experience in Using Multiple Feature Extractors and The Cancer Imaging Archive Data.
Lin Lu, Shawn H Sun, +4 authors, Binsheng Zhao.
Tomography, 2020 Jun 18; 6(2). PMID: 32548300    Free PMC article.
Diagnosis of triple negative breast cancer based on radiomics signatures extracted from preoperative contrast-enhanced chest computed tomography.
Qingliang Feng, Qiang Hu, +2 authors, Ziyi Yin.
BMC Cancer, 2020 Jun 24; 20(1). PMID: 32571245    Free PMC article.
Using CT texture analysis to differentiate between peripheral lung cancer and pulmonary inflammatory pseudotumor.
Chenlu Liu, Changsheng Ma, +4 authors, Yong Yin.
BMC Med Imaging, 2020 Jul 08; 20(1). PMID: 32631330    Free PMC article.
Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy.
Stuart L Polk, Jung W Choi, +10 authors, Daniel Jeong.
World J Gastroenterol, 2020 Jul 14; 26(24). PMID: 32655269    Free PMC article.
Current Landscape of Breast Cancer Imaging and Potential Quantitative Imaging Markers of Response in ER-Positive Breast Cancers Treated with Neoadjuvant Therapy.
Ella F Jones, Deep K Hathi, +6 authors, Nola M Hylton.
Cancers (Basel), 2020 Jun 13; 12(6). PMID: 32527022    Free PMC article.
Radiomics: from qualitative to quantitative imaging.
William Rogers, Sithin Thulasi Seetha, +14 authors, Philippe Lambin.
Br J Radiol, 2020 Feb 27; 93(1108). PMID: 32101448    Free PMC article.
Radiomics of Coronary Artery Calcium in the Framingham Heart Study.
Parastou Eslami, Chintan Parmar, +13 authors, Udo Hoffmann.
Radiol Cardiothorac Imaging, 2020 Jul 28; 2(1). PMID: 32715301    Free PMC article.
Overview of radiomics in breast cancer diagnosis and prognostication.
Alberto Stefano Tagliafico, Michele Piana, +3 authors, Nehmat Houssami.
Breast, 2019 Nov 19; 49. PMID: 31739125    Free PMC article.
Radiomics as a personalized medicine tool in lung cancer: Separating the hope from the hype.
Isabella Fornacon-Wood, Corinne Faivre-Finn, James P B O'Connor, Gareth J Price.
Lung Cancer, 2020 Jun 21; 146. PMID: 32563015    Free PMC article.
Overall Survival Prediction in Glioblastoma With Radiomic Features Using Machine Learning.
Ujjwal Baid, Swapnil U Rane, +4 authors, Abhishek Mahajan.
Front Comput Neurosci, 2020 Aug 28; 14. PMID: 32848682    Free PMC article.
Survival prediction for oral tongue cancer patients via probabilistic genetic algorithm optimized neural network models.
Xiaoying Pan, Ting Zhang, +3 authors, X Sharon Qi.
Br J Radiol, 2020 Jun 11; 93(1112). PMID: 32520585    Free PMC article.
Clinical value of texture analysis in differentiation of urothelial carcinoma based on multiphase computed tomography images.
Zihua Wang, Yufang He, +4 authors, Lei Mo.
Medicine (Baltimore), 2020 May 03; 99(18). PMID: 32358396    Free PMC article.
Radiomics Nomogram for Prediction of Peritoneal Metastasis in Patients With Gastric Cancer.
Weicai Huang, Kangneng Zhou, +13 authors, Guoxin Li.
Front Oncol, 2020 Sep 26; 10. PMID: 32974149    Free PMC article.
The Feasibility Study of Megavoltage Computed Tomographic (MVCT) Image for Texture Feature Analysis.
Jiabing Gu, Jian Zhu, +4 authors, Yong Yin.
Front Oncol, 2018 Dec 21; 8. PMID: 30568918    Free PMC article.
Radiomics - the value of the numbers in present and future radiology.
Mateusz Patyk, Jurand Silicki, +3 authors, Urszula Zaleska-Dorobisz.
Pol J Radiol, 2019 Jan 11; 83. PMID: 30627231    Free PMC article.
Optimal respiratory-gated [18F]FDG PET/CT significantly impacts the quantification of metabolic parameters and their correlation with overall survival in patients with pancreatic ductal adenocarcinoma.
Esther M M Smeets, Dominique S Withaar, +5 authors, Erik H J G Aarntzen.
EJNMMI Res, 2019 Mar 15; 9(1). PMID: 30868318    Free PMC article.
Application of computed tomography-based radiomics signature analysis in the prediction of the response of small cell lung cancer patients to first-line chemotherapy.
Haifeng Wei, Fengchang Yang, +7 authors, Ximing Wang.
Exp Ther Med, 2019 Apr 17; 17(5). PMID: 30988745    Free PMC article.
Reproducibility and non-redundancy of radiomic features extracted from arterial phase CT scans in hepatocellular carcinoma patients: impact of tumor segmentation variability.
Qingtao Qiu, Jinghao Duan, +6 authors, Yong Yin.
Quant Imaging Med Surg, 2019 Apr 30; 9(3). PMID: 31032192    Free PMC article.
Radiomics Signature on Computed Tomography Imaging: Association With Lymph Node Metastasis in Patients With Gastric Cancer.
Yuming Jiang, Wei Wang, +12 authors, Guoxin Li.
Front Oncol, 2019 May 21; 9. PMID: 31106158    Free PMC article.
An image-based deep learning framework for individualizing radiotherapy dose.
Bin Lou, Semihcan Doken, +6 authors, Mohamed E Abazeed.
Lancet Digit Health, 2019 Aug 27; 1(3). PMID: 31448366    Free PMC article.
Image-based simulation and modeling: unlocking small airway function tests?
Alex Bell, Salman Siddiqui.
J Appl Physiol (1985), 2020 Jul 24; 129(3). PMID: 32702265    Free PMC article.
Exploratory Study of a CT Radiomics Model for the Classification of Small Cell Lung Cancer and Non-small-Cell Lung Cancer.
Shihe Liu, Shunli Liu, +6 authors, Qing Fu.
Front Oncol, 2020 Oct 06; 10. PMID: 33014770    Free PMC article.
Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.
Chunhao Wang, Chenyang Liu, +7 authors, Fang-Fang Yin.
Front Oncol, 2020 Oct 06; 10. PMID: 33014811    Free PMC article.
Non-invasive evaluation for benign and malignant subcentimeter pulmonary ground-glass nodules (≤1 cm) based on CT texture analysis.
Xianghua Hu, Weichuan Ye, +10 authors, Jiansong Ji.
Br J Radiol, 2020 Jul 21; 93(1114). PMID: 32686958    Free PMC article.
Novel, non-invasive imaging approach to identify patients with advanced non-small cell lung cancer at risk of hyperprogressive disease with immune checkpoint blockade.
Pranjal Vaidya, Kaustav Bera, +6 authors, Anant Madabhushi.
J Immunother Cancer, 2020 Oct 15; 8(2). PMID: 33051342    Free PMC article.
Radiomic Analysis of MRI Images is Instrumental to the Stratification of Ovarian Cysts.
Roxana-Adelina Lupean, Paul-Andrei Ștefan, +5 authors, Carmen Mihaela Mihu.
J Pers Med, 2020 Sep 18; 10(3). PMID: 32937851    Free PMC article.
XGBoost Improves Classification of MGMT Promoter Methylation Status in IDH1 Wildtype Glioblastoma.
Nguyen Quoc Khanh Le, Duyen Thi Do, +3 authors, Cheng-Yu Chen.
J Pers Med, 2020 Sep 19; 10(3). PMID: 32942564    Free PMC article.
Differentiating Hepatic Epithelioid Angiomyolipoma From Hepatocellular Carcinoma and Focal Nodular Hyperplasia via Radiomics Models.
Wenjie Liang, Jiayuan Shao, +7 authors, Wenbo Xiao.
Front Oncol, 2020 Oct 31; 10. PMID: 33123475    Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
[Research Advances and Obstacles of CT-based Radiomics in Diagnosis and Treatment of Lung Cancer].
Jiawei Li, Xiadong Li, Xueqin Chen, Shenglin Ma.
Zhongguo Fei Ai Za Zhi, 2020 Aug 18; 23(10). PMID: 32798440    Free PMC article.
[A radiomics-based model for differentiation between benign and malignant gastrointestinal stromal tumors].
Wenhua Zhang, Tao Chen, +2 authors, Zhentai Lu.
Nan Fang Yi Ke Da Xue Xue Bao, 2018 Jan 30; 38(1). PMID: 33177032    Free PMC article.
The Current State of Radiomics for Meningiomas: Promises and Challenges.
Hao Gu, Xu Zhang, +2 authors, Tao Xu.
Front Oncol, 2020 Nov 17; 10. PMID: 33194649    Free PMC article.
Youyi Zhang, Jeffrey S Morris, +2 authors, Veerabhadran Baladandayuthapani.
Ann Appl Stat, 2019 Jan 01; 13(3). PMID: 33224404    Free PMC article.
Radiomics Signatures of Cardiovascular Risk Factors in Cardiac MRI: Results From the UK Biobank.
Irem Cetin, Zahra Raisi-Estabragh, +6 authors, Karim Lekadir.
Front Cardiovasc Med, 2020 Nov 27; 7. PMID: 33240940    Free PMC article.
Can Magnetic Resonance Radiomics Analysis Discriminate Parotid Gland Tumors? A Pilot Study.
Michela Gabelloni, Lorenzo Faggioni, +9 authors, Emanuele Neri.
Diagnostics (Basel), 2020 Nov 07; 10(11). PMID: 33153140    Free PMC article.
[Radiomics: Big Data Instead of Biopsies in the Future?]
Kathrin Scheckenbach.
Laryngorhinootologie, 2018 Jun 16; 97(S 01). PMID: 29905355    Free PMC article.
A review on radiomics and the future of theranostics for patient selection in precision medicine.
Simon A Keek, Ralph Th Leijenaar, Arthur Jochems, Henry C Woodruff.
Br J Radiol, 2018 Jun 28; 91(1091). PMID: 29947266    Free PMC article.
Development and validation of a magnetic resonance imaging-based model for the prediction of distant metastasis before initial treatment of nasopharyngeal carcinoma: A retrospective cohort study.
Lu Zhang, Di Dong, +12 authors, Shuixing Zhang.
EBioMedicine, 2019 Jan 16; 40. PMID: 30642750    Free PMC article.
Radiomic analysis of planning computed tomograms for predicting radiation-induced lung injury and outcome in lung cancer patients treated with robotic stereotactic body radiation therapy.
Khaled Bousabarah, Susanne Temming, +7 authors, Harald Treuer.
Strahlenther Onkol, 2019 Mar 16; 195(9). PMID: 30874846
Prediction early recurrence of hepatocellular carcinoma eligible for curative ablation using a Radiomics nomogram.
Chunwang Yuan, Zhenchang Wang, +10 authors, Jiliang Feng.
Cancer Imaging, 2019 Apr 28; 19(1). PMID: 31027510    Free PMC article.
Prediction of pathologic stage in non-small cell lung cancer using machine learning algorithm based on CT image feature analysis.
Lingming Yu, Guangyu Tao, +4 authors, Qunhui Chen.
BMC Cancer, 2019 May 19; 19(1). PMID: 31101024    Free PMC article.
Radiomics model for distinguishing tuberculosis and lung cancer on computed tomography scans.
E-Nuo Cui, Tao Yu, +6 authors, Xi-Ran Jiang.
World J Clin Cases, 2020 Dec 04; 8(21). PMID: 33269256    Free PMC article.
Repeatability of Cardiac Magnetic Resonance Radiomics: A Multi-Centre Multi-Vendor Test-Retest Study.
Zahra Raisi-Estabragh, Polyxeni Gkontra, +10 authors, Steffen E Petersen.
Front Cardiovasc Med, 2020 Dec 22; 7. PMID: 33344517    Free PMC article.
Identifying Cross-Scale Associations between Radiomic and Pathomic Signatures of Non-Small Cell Lung Cancer Subtypes: Preliminary Results.
Charlems Alvarez-Jimenez, Alvaro A Sandino, +3 authors, Eduardo Romero.
Cancers (Basel), 2020 Dec 11; 12(12). PMID: 33297357    Free PMC article.
Radiomics Feature Activation Maps as a New Tool for Signature Interpretability.
Diem Vuong, Stephanie Tanadini-Lang, +9 authors, Marta Bogowicz.
Front Oncol, 2020 Dec 29; 10. PMID: 33364192    Free PMC article.
Machine Learning Methods for Optimal Radiomics-Based Differentiation Between Recurrence and Inflammation: Application to Nasopharyngeal Carcinoma Post-therapy PET/CT Images.
Dongyang Du, Hui Feng, +8 authors, Lijun Lu.
Mol Imaging Biol, 2019 Jul 25; 22(3). PMID: 31338709
Use of relative CT values to evaluate the invasiveness of pulmonary subsolid nodules in patients with emphysema.
Bo-Wei Zhang, Yu Zhang, Jian-Ding Ye, Jin-Wei Qiang.
Quant Imaging Med Surg, 2021 Jan 05; 11(1). PMID: 33392022    Free PMC article.
A Novel Nomogram Model Based on Cone-Beam CT Radiomics Analysis Technology for Predicting Radiation Pneumonitis in Esophageal Cancer Patients Undergoing Radiotherapy.
Feng Du, Ning Tang, +4 authors, Jianbin Li.
Front Oncol, 2021 Jan 05; 10. PMID: 33392091    Free PMC article.
A Radiomics Signature to Quantitatively Analyze COVID-19-Infected Pulmonary Lesions.
Jiajun Qiu, Shaoliang Peng, +5 authors, Wei Zhang.
Interdiscip Sci, 2021 Jan 08;. PMID: 33411162    Free PMC article.
YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas.
Wei Xu, Mingjiong Zhang, +8 authors, Jianqing Wu.
Cancer Cell Int, 2021 Jan 09; 21(1). PMID: 33413409    Free PMC article.
Automatic recognition and analysis of metal streak artifacts in head and neck computed tomography for radiomics modeling.
Lise Wei, Benjamin Rosen, +4 authors, Issam El Naqa.
Phys Imaging Radiat Oncol, 2019 Jun 06; 10. PMID: 33458268    Free PMC article.
Preoperatively Estimating the Malignant Potential of Mediastinal Lymph Nodes: A Pilot Study Toward Establishing a Robust Radiomics Model Based on Contrast-Enhanced CT Imaging.
Mengshi Dong, Gang Hou, +3 authors, Ke Xu.
Front Oncol, 2021 Jan 26; 10. PMID: 33489871    Free PMC article.
Radiomics in lung cancer for oncologists.
Carolina de la Pinta, Nuria Barrios-Campo, David Sevillano.
J Clin Transl Res, 2021 Feb 02; 6(4). PMID: 33521373    Free PMC article.
Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis.
Yexun Song, Wenfang Tang, Hui Li.
Biosci Rep, 2021 Jan 06; 41(1). PMID: 33398330    Free PMC article.
Radiomics signature on CECT as a predictive factor for invasiveness of lung adenocarcinoma manifesting as subcentimeter ground glass nodules.
Wufei Chen, Ming Li, +9 authors, Hao Wu.
Sci Rep, 2021 Feb 13; 11(1). PMID: 33574448    Free PMC article.
The Impact of Preoperative Radiomics Signature on the Survival of Breast Cancer Patients With Residual Tumors After NAC.
Ling Zhang, Xinhua Jiang, +5 authors, Li Li.
Front Oncol, 2021 Feb 23; 10. PMID: 33614472    Free PMC article.