Journal Article
. 2015 Mar;114(3).
doi: 10.1016/j.radonc.2015.02.015.

CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma

Thibaud P Coroller 1 Patrick Grossmann 2 Ying Hou 3 Emmanuel Rios Velazquez 3 Ralph T H Leijenaar 4 Gretchen Hermann 3 Philippe Lambin 4 Benjamin Haibe-Kains 5 Raymond H Mak 3 Hugo J W L Aerts 6 
Affiliations
  • PMID: 25746350
  •     35 References
  •     207 citations

Abstract

Background And Purpose: Radiomics provides opportunities to quantify the tumor phenotype non-invasively by applying a large number of quantitative imaging features. This study evaluates computed-tomography (CT) radiomic features for their capability to predict distant metastasis (DM) for lung adenocarcinoma patients.

Material And Methods: We included two datasets: 98 patients for discovery and 84 for validation. The phenotype of the primary tumor was quantified on pre-treatment CT-scans using 635 radiomic features. Univariate and multivariate analysis was performed to evaluate radiomics performance using the concordance index (CI).

Results: Thirty-five radiomic features were found to be prognostic (CI>0.60, FDR<5%) for DM and twelve for survival. It is noteworthy that tumor volume was only moderately prognostic for DM (CI=0.55, p-value=2.77×10(-5)) in the discovery cohort. A radiomic-signature had strong power for predicting DM in the independent validation dataset (CI=0.61, p-value=1.79×10(-17)). Adding this radiomic-signature to a clinical model resulted in a significant improvement of predicting DM in the validation dataset (p-value=1.56×10(-11)).

Conclusions: Although only basic metrics are routinely quantified, this study shows that radiomic features capturing detailed information of the tumor phenotype can be used as a prognostic biomarker for clinically-relevant factors such as DM. Moreover, the radiomic-signature provided additional information to clinical data.

Keywords: Biomarkers; Distant metastasis; Lung adenocarcinoma; NSCLC; Quantitative imaging; Radiomics.

Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival.
Balaji Ganeshan, Elleny Panayiotou, +2 authors, Ken Miles.
Eur Radiol, 2011 Nov 17; 22(4). PMID: 22086561
Highly Cited.
Texture analysis of advanced non-small cell lung cancer (NSCLC) on contrast-enhanced computed tomography: prediction of the response to the first-line chemotherapy.
Marco Ravanelli, Davide Farina, +4 authors, Roberto Maroldi.
Eur Radiol, 2013 Jul 10; 23(12). PMID: 23835926
survcomp: an R/Bioconductor package for performance assessment and comparison of survival models.
Markus S Schröder, Aedín C Culhane, John Quackenbush, Benjamin Haibe-Kains.
Bioinformatics, 2011 Sep 10; 27(22). PMID: 21903630    Free PMC article.
Highly Cited.
Non-small cell lung cancer: histopathologic correlates for texture parameters at CT.
Balaji Ganeshan, Vicky Goh, +3 authors, Kenneth A Miles.
Radiology, 2012 Nov 22; 266(1). PMID: 23169792
Highly Cited.
CERR: a computational environment for radiotherapy research.
Joseph O Deasy, Angel I Blanco, Vanessa H Clark.
Med Phys, 2003 May 30; 30(5). PMID: 12773007
Highly Cited.
Reproducibility and Prognosis of Quantitative Features Extracted from CT Images.
Yoganand Balagurunathan, Yuhua Gu, +8 authors, Robert J Gillies.
Transl Oncol, 2014 Apr 29; 7(1). PMID: 24772210    Free PMC article.
Highly Cited.
Evaluating the yield of medical tests.
F E Harrell, R M Califf, +2 authors, R A Rosati.
JAMA, 1982 May 14; 247(18). PMID: 7069920
Highly Cited.
Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: a prospective validation.
Hugo J W L Aerts, Johan Bussink, +6 authors, Dirk De Ruysscher.
Lung Cancer, 2011 Jul 26; 75(1). PMID: 21782272
Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach.
Hugo J W L Aerts, Emmanuel Rios Velazquez, +15 authors, Philippe Lambin.
Nat Commun, 2014 Jun 04; 5. PMID: 24892406    Free PMC article.
Highly Cited.
Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410.
Walter J Curran, Rebecca Paulus, +10 authors, James D Cox.
J Natl Cancer Inst, 2011 Sep 10; 103(19). PMID: 21903745    Free PMC article.
Highly Cited.
Tumor volume is a prognostic factor in non-small-cell lung cancer treated with chemoradiotherapy.
Brian M Alexander, Megan Othus, Hale B Caglar, Aaron M Allen.
Int J Radiat Oncol Biol Phys, 2010 Jul 08; 79(5). PMID: 20605346
Radiomics: extracting more information from medical images using advanced feature analysis.
Philippe Lambin, Emmanuel Rios-Velazquez, +8 authors, Hugo J W L Aerts.
Eur J Cancer, 2012 Jan 20; 48(4). PMID: 22257792    Free PMC article.
Highly Cited. Review.
Assessment of tumor heterogeneity: an emerging imaging tool for clinical practice?
Fergus Davnall, Connie S P Yip, +7 authors, Vicky Goh.
Insights Imaging, 2012 Oct 25; 3(6). PMID: 23093486    Free PMC article.
Highly Cited.
Measurements of heterogeneity in gliomas on computed tomography relationship to tumour grade.
Karoline Skogen, Balaji Ganeshan, +2 authors, Ken Miles.
J Neurooncol, 2012 Dec 12; 111(2). PMID: 23224678
The 7th lung cancer TNM classification and staging system: Review of the changes and implications.
Saeed Mirsadraee, Dilip Oswal, +2 authors, Edwin van Beek.
World J Radiol, 2012 May 17; 4(4). PMID: 22590666    Free PMC article.
Highly Cited.
Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability.
Ralph T H Leijenaar, Sara Carvalho, +9 authors, Philippe Lambin.
Acta Oncol, 2013 Sep 21; 52(7). PMID: 24047337    Free PMC article.
Highly Cited.
Bioconductor: open software development for computational biology and bioinformatics.
Robert C Gentleman, Vincent J Carey, +22 authors, Jianhua Zhang.
Genome Biol, 2004 Oct 06; 5(10). PMID: 15461798    Free PMC article.
Highly Cited.
Computerized texture analysis of persistent part-solid ground-glass nodules: differentiation of preinvasive lesions from invasive pulmonary adenocarcinomas.
Hee-Dong Chae, Chang Min Park, +3 authors, Jin Mo Goo.
Radiology, 2014 Aug 08; 273(1). PMID: 25102296
Highly Cited.
Toxicity and response criteria of the Eastern Cooperative Oncology Group.
M M Oken, R H Creech, +4 authors, P P Carbone.
Am J Clin Oncol, 1982 Dec 01; 5(6). PMID: 7165009
Highly Cited.
Combined PET/CT image characteristics for radiotherapy tumor response in lung cancer.
Manushka Vaidya, Kimberly M Creach, +3 authors, Issam El Naqa.
Radiother Oncol, 2011 Nov 22; 102(2). PMID: 22098794
Predicting outcomes in radiation oncology--multifactorial decision support systems.
Philippe Lambin, Ruud G P M van Stiphout, +11 authors, Andre Dekker.
Nat Rev Clin Oncol, 2012 Nov 21; 10(1). PMID: 23165123    Free PMC article.
Highly Cited. Review.
Radiomics: the process and the challenges.
Virendra Kumar, Yuhua Gu, +13 authors, Robert J Gillies.
Magn Reson Imaging, 2012 Aug 18; 30(9). PMID: 22898692    Free PMC article.
Highly Cited. Review.
Texture analysis of non-small cell lung cancer on unenhanced computed tomography: initial evidence for a relationship with tumour glucose metabolism and stage.
Balaji Ganeshan, Sandra Abaleke, +2 authors, Kenneth A Miles.
Cancer Imaging, 2010 Jul 08; 10. PMID: 20605762    Free PMC article.
Highly Cited.
Robust Radiomics feature quantification using semiautomatic volumetric segmentation.
Chintan Parmar, Emmanuel Rios Velazquez, +9 authors, Hugo J W L Aerts.
PLoS One, 2014 Jul 16; 9(7). PMID: 25025374    Free PMC article.
Highly Cited.
mRMRe: an R package for parallelized mRMR ensemble feature selection.
Nicolas De Jay, Simon Papillon-Cavanagh, +3 authors, Benjamin Haibe-Kains.
Bioinformatics, 2013 Jul 05; 29(18). PMID: 23825369
Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023.
Karen Kelly, Kari Chansky, +6 authors, David R Gandara.
J Clin Oncol, 2008 Apr 02; 26(15). PMID: 18378568
Highly Cited.
Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial.
Kathy S Albain, R Suzanne Swann, +15 authors, James D Cox.
Lancet, 2009 Jul 28; 374(9687). PMID: 19632716    Free PMC article.
Highly Cited.
The complex relationship between lung tumor volume and survival in patients with non-small cell lung cancer treated by definitive radiotherapy: a prospective, observational prognostic factor study of the Trans-Tasman Radiation Oncology Group (TROG 99.05).
David L Ball, Richard J Fisher, +8 authors, Bev E McClure.
Radiother Oncol, 2013 Jan 22; 106(3). PMID: 23333017
Cancer statistics, 2014.
Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal.
CA Cancer J Clin, 2014 Jan 09; 64(1). PMID: 24399786
Highly Cited.
Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer.
W van Elmpt, M Das, +8 authors, D De Ruysscher.
Radiother Oncol, 2013 Sep 21; 109(1). PMID: 24044795    Free PMC article.
Computerized characterization of lung nodule subtlety using thoracic CT images.
Xin He, Berkman Sahiner, +2 authors, Nicholas Petrick.
Phys Med Biol, 2014 Feb 04; 59(4). PMID: 24487773
Influence of tumor volume on survival in patients irradiated for non-small-cell lung cancer.
Durmus Etiz, Lawrence B Marks, +4 authors, Pehr A Lind.
Int J Radiat Oncol Biol Phys, 2002 Jul 04; 53(4). PMID: 12095548
Prognostic value and reproducibility of pretreatment CT texture features in stage III non-small cell lung cancer.
David V Fried, Susan L Tucker, +4 authors, Laurence E Court.
Int J Radiat Oncol Biol Phys, 2014 Sep 16; 90(4). PMID: 25220716    Free PMC article.
Highly Cited.
A semiautomatic CT-based ensemble segmentation of lung tumors: comparison with oncologists' delineations and with the surgical specimen.
Emmanuel Rios Velazquez, Hugo J W L Aerts, +6 authors, Philippe Lambin.
Radiother Oncol, 2012 Nov 20; 105(2). PMID: 23157978    Free PMC article.
Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non-small-cell lung cancer: the Hoosier Oncology Group and U.S. Oncology.
Nasser Hanna, Marcus Neubauer, +19 authors, US Oncology.
J Clin Oncol, 2008 Nov 13; 26(35). PMID: 19001323
Highly Cited.
Validation of functional imaging as a biomarker for radiation treatment response.
C Jentsch, B Beuthien-Baumann, E G C Troost, G Shakirin.
Br J Radiol, 2015 Jun 18; 88(1051). PMID: 26083533    Free PMC article.
Review.
The effect of SUV discretization in quantitative FDG-PET Radiomics: the need for standardized methodology in tumor texture analysis.
Ralph T H Leijenaar, Georgi Nalbantov, +6 authors, Philippe Lambin.
Sci Rep, 2015 Aug 06; 5. PMID: 26242464    Free PMC article.
Highly Cited.
Machine Learning methods for Quantitative Radiomic Biomarkers.
Chintan Parmar, Patrick Grossmann, +2 authors, Hugo J W L Aerts.
Sci Rep, 2015 Aug 19; 5. PMID: 26278466    Free PMC article.
Highly Cited.
Radiomics: Images Are More than Pictures, They Are Data.
Robert J Gillies, Paul E Kinahan, Hedvig Hricak.
Radiology, 2015 Nov 19; 278(2). PMID: 26579733    Free PMC article.
Highly Cited.
Can radiomics features be reproducibly measured from CBCT images for patients with non-small cell lung cancer?
Xenia Fave, Dennis Mackin, +9 authors, Laurence Court.
Med Phys, 2015 Dec 04; 42(12). PMID: 26632036    Free PMC article.
Variability of Image Features Computed from Conventional and Respiratory-Gated PET/CT Images of Lung Cancer.
Jasmine A Oliver, Mikalai Budzevich, +3 authors, Eduardo G Moros.
Transl Oncol, 2015 Dec 23; 8(6). PMID: 26692535    Free PMC article.
Radiomic Machine-Learning Classifiers for Prognostic Biomarkers of Head and Neck Cancer.
Chintan Parmar, Patrick Grossmann, +3 authors, Hugo J W L Aerts.
Front Oncol, 2015 Dec 24; 5. PMID: 26697407    Free PMC article.
Highly Cited.
Respiration-Averaged CT for Attenuation Correction of PET Images - Impact on PET Texture Features in Non-Small Cell Lung Cancer Patients.
Nai-Ming Cheng, Yu-Hua Dean Fang, +2 authors, Tzu-Chen Yen.
PLoS One, 2016 Mar 02; 11(3). PMID: 26930211    Free PMC article.
Technical Note: FreeCT_wFBP: A robust, efficient, open-source implementation of weighted filtered backprojection for helical, fan-beam CT.
John Hoffman, Stefano Young, Frédéric Noo, Michael McNitt-Gray.
Med Phys, 2016 Mar 05; 43(3). PMID: 26936725    Free PMC article.
Reproducibility of radiomics for deciphering tumor phenotype with imaging.
Binsheng Zhao, Yongqiang Tan, +4 authors, Lawrence H Schwartz.
Sci Rep, 2016 Mar 25; 6. PMID: 27009765    Free PMC article.
Highly Cited.
Radiomic Features Are Associated With EGFR Mutation Status in Lung Adenocarcinomas.
Ying Liu, Jongphil Kim, +5 authors, Robert J Gillies.
Clin Lung Cancer, 2016 Mar 28; 17(5). PMID: 27017476    Free PMC article.
Highly Cited.
Early-Stage Non-Small Cell Lung Cancer: Quantitative Imaging Characteristics of (18)F Fluorodeoxyglucose PET/CT Allow Prediction of Distant Metastasis.
Jia Wu, Todd Aguilera, +5 authors, Ruijiang Li.
Radiology, 2016 Apr 06; 281(1). PMID: 27046074    Free PMC article.
Highly Cited.
Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology.
Weimiao Wu, Chintan Parmar, +5 authors, Hugo J W L Aerts.
Front Oncol, 2016 Apr 12; 6. PMID: 27064691    Free PMC article.
Highly Cited.
Radiomic phenotype features predict pathological response in non-small cell lung cancer.
Thibaud P Coroller, Vishesh Agrawal, +5 authors, Hugo J W L Aerts.
Radiother Oncol, 2016 Apr 18; 119(3). PMID: 27085484    Free PMC article.
Highly Cited.
The development and validation of a CT-based radiomics signature for the preoperative discrimination of stage I-II and stage III-IV colorectal cancer.
Cuishan Liang, Yanqi Huang, +6 authors, Zaiyi Liu.
Oncotarget, 2016 Apr 28; 7(21). PMID: 27120787    Free PMC article.
Robust Intratumor Partitioning to Identify High-Risk Subregions in Lung Cancer: A Pilot Study.
Jia Wu, Michael F Gensheimer, +5 authors, Ruijiang Li.
Int J Radiat Oncol Biol Phys, 2016 May 24; 95(5). PMID: 27212196    Free PMC article.
Applications and limitations of radiomics.
Stephen S F Yip, Hugo J W L Aerts.
Phys Med Biol, 2016 Jun 09; 61(13). PMID: 27269645    Free PMC article.
Highly Cited. Review.
Vision 20/20: Molecular-guided surgical oncology based upon tumor metabolism or immunologic phenotype: Technological pathways for point of care imaging and intervention.
Brian W Pogue, Keith D Paulsen, +5 authors, Joachim Feldwisch.
Med Phys, 2016 Jun 10; 43(6). PMID: 27277060    Free PMC article.
Combining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms.
Jennifer B Permuth, Jung Choi, +19 authors, Florida Pancreas Collaborative.
Oncotarget, 2016 Sep 03; 7(52). PMID: 27589689    Free PMC article.
Defining a Radiomic Response Phenotype: A Pilot Study using targeted therapy in NSCLC.
Hugo J W L Aerts, Patrick Grossmann, +4 authors, Binsheng Zhao.
Sci Rep, 2016 Sep 21; 6. PMID: 27645803    Free PMC article.
Highly Cited.
Magnetic Resonance Imaging-Based Radiomic Profiles Predict Patient Prognosis in Newly Diagnosed Glioblastoma Before Therapy.
Sean D McGarry, Sarah L Hurrell, +5 authors, Peter S LaViolette.
Tomography, 2016 Oct 25; 2(3). PMID: 27774518    Free PMC article.
Lung cancer screening: not all nodules are created equal.
Gaurav Shukla, Noelle L Williams, +2 authors, Wenyin Shi.
J Thorac Dis, 2016 Nov 22; 8(10). PMID: 27867602    Free PMC article.
An Exploratory Study to Detect Ménière's Disease in Conventional MRI Scans Using Radiomics.
E L van den Burg, M van Hoof, +4 authors, R van de Berg.
Front Neurol, 2016 Nov 23; 7. PMID: 27872606    Free PMC article.
Pathologic stratification of operable lung adenocarcinoma using radiomics features extracted from dual energy CT images.
Jung Min Bae, Ji Yun Jeong, +7 authors, Young Mog Shim.
Oncotarget, 2016 Nov 24; 8(1). PMID: 27880938    Free PMC article.
Radiomic-Based Pathological Response Prediction from Primary Tumors and Lymph Nodes in NSCLC.
Thibaud P Coroller, Vishesh Agrawal, +4 authors, Hugo J W L Aerts.
J Thorac Oncol, 2016 Dec 03; 12(3). PMID: 27903462    Free PMC article.
Texture analysis of intermediate-advanced hepatocellular carcinoma: prognosis and patients' selection of transcatheter arterial chemoembolization and sorafenib.
Sirui Fu, Shuting Chen, +4 authors, Ligong Lu.
Oncotarget, 2016 Dec 03; 8(23). PMID: 27911268    Free PMC article.
Non-small cell lung cancer: quantitative phenotypic analysis of CT images as a potential marker of prognosis.
Jiangdian Song, Zaiyi Liu, +5 authors, Jie Tian.
Sci Rep, 2016 Dec 07; 6. PMID: 27922113    Free PMC article.
Quantitative radiomics studies for tissue characterization: a review of technology and methodological procedures.
Ruben T H M Larue, Gilles Defraene, +2 authors, Wouter van Elmpt.
Br J Radiol, 2016 Dec 13; 90(1070). PMID: 27936886    Free PMC article.
Highly Cited. Review.
Radiomics: a new application from established techniques.
Vishwa Parekh, Michael A Jacobs.
Expert Rev Precis Med Drug Dev, 2017 Jan 04; 1(2). PMID: 28042608    Free PMC article.
Highly Cited.
Associations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRT.
Elizabeth Huynh, Thibaud P Coroller, +7 authors, Hugo J W L Aerts.
PLoS One, 2017 Jan 04; 12(1). PMID: 28046060    Free PMC article.
Intrinsic dependencies of CT radiomic features on voxel size and number of gray levels.
Muhammad Shafiq-Ul-Hassan, Geoffrey G Zhang, +10 authors, Eduardo Gerardo Moros.
Med Phys, 2017 Jan 24; 44(3). PMID: 28112418    Free PMC article.
Highly Cited.
CT texture analysis: a potential tool for prediction of survival in patients with metastatic clear cell carcinoma treated with sunitinib.
Masoom A Haider, Alireza Vosough, +3 authors, Georg A Bjarnason.
Cancer Imaging, 2017 Jan 25; 17(1). PMID: 28114978    Free PMC article.
Associations between Tumor Vascularity, Vascular Endothelial Growth Factor Expression and PET/MRI Radiomic Signatures in Primary Clear-Cell-Renal-Cell-Carcinoma: Proof-of-Concept Study.
Qingbo Yin, Sheng-Che Hung, +9 authors, Dinggang Shen.
Sci Rep, 2017 Mar 04; 7. PMID: 28256615    Free PMC article.
Potential Application of Radiomics for Differentiating Solitary Pulmonary Nodules.
Kaikai Wei, Huifang Su, +6 authors, Zhenfeng Zhang.
OMICS J Radiol, 2016 Jan 01; 5(2). PMID: 28261535    Free PMC article.
Radiomics of pulmonary nodules and lung cancer.
Ryan Wilson, Anand Devaraj.
Transl Lung Cancer Res, 2017 Mar 24; 6(1). PMID: 28331828    Free PMC article.
Review.
Delta-radiomics features for the prediction of patient outcomes in non-small cell lung cancer.
Xenia Fave, Lifei Zhang, +9 authors, Laurence Court.
Sci Rep, 2017 Apr 05; 7(1). PMID: 28373718    Free PMC article.
Highly Cited.
Grading of Gliomas by Using Radiomic Features on Multiple Magnetic Resonance Imaging (MRI) Sequences.
Jiang-Bo Qin, Zhenyu Liu, +6 authors, Jie Tian.
Med Sci Monit, 2017 May 10; 23. PMID: 28478462    Free PMC article.
Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer.
Emmanuel Rios Velazquez, Chintan Parmar, +10 authors, Hugo J W L Aerts.
Cancer Res, 2017 Jun 02; 77(14). PMID: 28566328    Free PMC article.
Highly Cited.
Application of the 3D slicer chest imaging platform segmentation algorithm for large lung nodule delineation.
Stephen S F Yip, Chintan Parmar, +4 authors, Hugo J W L Aerts.
PLoS One, 2017 Jun 09; 12(6). PMID: 28594880    Free PMC article.
Associations between radiologist-defined semantic and automatically computed radiomic features in non-small cell lung cancer.
Stephen S F Yip, Ying Liu, +6 authors, Hugo J W L Aerts.
Sci Rep, 2017 Jun 16; 7(1). PMID: 28615677    Free PMC article.
CT texture features are associated with overall survival in pancreatic ductal adenocarcinoma - a quantitative analysis.
Armin Eilaghi, Sameer Baig, +5 authors, Masoom A Haider.
BMC Med Imaging, 2017 Jun 21; 17(1). PMID: 28629416    Free PMC article.
Highly Cited.
Matched computed tomography segmentation and demographic data for oropharyngeal cancer radiomics challenges.
MICCAI/M.D. Anderson Cancer Center Head and Neck Quantitative Imaging Working Group.
Sci Data, 2017 Jul 05; 4. PMID: 28675381    Free PMC article.
"Radio-oncomics" : The potential of radiomics in radiation oncology.
Jan Caspar Peeken, Fridtjof Nüsslin, Stephanie E Combs.
Strahlenther Onkol, 2017 Jul 09; 193(10). PMID: 28687979
Review.
Investigating the Robustness Neighborhood Gray Tone Difference Matrix and Gray Level Co-occurrence Matrix Radiomic Features on Clinical Computed Tomography Systems Using Anthropomorphic Phantoms: Evidence From a Multivendor Study.
Usman Mahmood, Aditya P Apte, +2 authors, Amita Shukla-Dave.
J Comput Assist Tomogr, 2017 Jul 15; 41(6). PMID: 28708732    Free PMC article.
Defining the biological basis of radiomic phenotypes in lung cancer.
Patrick Grossmann, Olya Stringfield, +8 authors, Hugo Jwl Aerts.
Elife, 2017 Jul 22; 6. PMID: 28731408    Free PMC article.
Highly Cited.
Prognostic value and molecular correlates of a CT image-based quantitative pleural contact index in early stage NSCLC.
Juheon Lee, Yi Cui, +7 authors, Ruijiang Li.
Eur Radiol, 2017 Aug 09; 28(2). PMID: 28786009    Free PMC article.
Clinical applications of textural analysis in non-small cell lung cancer.
Iain Phillips, Mazhar Ajaz, +7 authors, Philip Evans.
Br J Radiol, 2017 Sep 05; 91(1081). PMID: 28869399    Free PMC article.
Systematic Review.
A Deep Learning-Based Radiomics Model for Prediction of Survival in Glioblastoma Multiforme.
Jiangwei Lao, Yinsheng Chen, +4 authors, Guangtao Zhai.
Sci Rep, 2017 Sep 06; 7(1). PMID: 28871110    Free PMC article.
Highly Cited.
Reproducibility of F18-FDG PET radiomic features for different cervical tumor segmentation methods, gray-level discretization, and reconstruction algorithms.
Baderaldeen A Altazi, Geoffrey G Zhang, +5 authors, Eduardo G Moros.
J Appl Clin Med Phys, 2017 Sep 12; 18(6). PMID: 28891217    Free PMC article.
Development and clinical application of radiomics in lung cancer.
Bojiang Chen, Rui Zhang, +2 authors, Weimin Li.
Radiat Oncol, 2017 Sep 17; 12(1). PMID: 28915902    Free PMC article.
Review.
2D and 3D CT Radiomics Features Prognostic Performance Comparison in Non-Small Cell Lung Cancer.
Chen Shen, Zhenyu Liu, +9 authors, Jie Tian.
Transl Oncol, 2017 Sep 21; 10(6). PMID: 28930698    Free PMC article.
Harmonizing the pixel size in retrospective computed tomography radiomics studies.
Dennis Mackin, Xenia Fave, +4 authors, Laurence Court.
PLoS One, 2017 Sep 22; 12(9). PMID: 28934225    Free PMC article.
Highly Cited.
Prediction of disease-free survival by the PET/CT radiomic signature in non-small cell lung cancer patients undergoing surgery.
Margarita Kirienko, Luca Cozzi, +6 authors, Martina Sollini.
Eur J Nucl Med Mol Imaging, 2017 Sep 26; 45(2). PMID: 28944403
Radiomics: the bridge between medical imaging and personalized medicine.
Philippe Lambin, Ralph T H Leijenaar, +17 authors, Sean Walsh.
Nat Rev Clin Oncol, 2017 Oct 05; 14(12). PMID: 28975929
Highly Cited. Review.
Quantitative Image Feature Engine (QIFE): an Open-Source, Modular Engine for 3D Quantitative Feature Extraction from Volumetric Medical Images.
Sebastian Echegaray, Shaimaa Bakr, Daniel L Rubin, Sandy Napel.
J Digit Imaging, 2017 Oct 11; 31(4). PMID: 28993897    Free PMC article.
Review.
A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling.
Stefan Leger, Alex Zwanenburg, +22 authors, Christian Richter.
Sci Rep, 2017 Oct 19; 7(1). PMID: 29038455    Free PMC article.
An Assessment of Imaging Informatics for Precision Medicine in Cancer.
C Chennubhotla, L P Clarke, +9 authors, A Sharma.
Yearb Med Inform, 2017 Oct 25; 26(1). PMID: 29063549    Free PMC article.
Review.
Interobserver variability in tumor contouring affects the use of radiomics to predict mutational status.
Qiao Huang, Lin Lu, +6 authors, Binsheng Zhao.
J Med Imaging (Bellingham), 2017 Nov 04; 5(1). PMID: 29098170    Free PMC article.
Radiographic prediction of meningioma grade by semantic and radiomic features.
Thibaud P Coroller, Wenya Linda Bi, +16 authors, Hugo J W L Aerts.
PLoS One, 2017 Nov 18; 12(11). PMID: 29145421    Free PMC article.
Pulmonary quantitative CT imaging in focal and diffuse disease: current research and clinical applications.
Mario Silva, Gianluca Milanese, +2 authors, Nicola Sverzellati.
Br J Radiol, 2017 Nov 28; 91(1083). PMID: 29172671    Free PMC article.
Review.
Quantitative Biomarkers for Prediction of Epidermal Growth Factor Receptor Mutation in Non-Small Cell Lung Cancer.
Liwen Zhang, Bojiang Chen, +6 authors, Jie Tian.
Transl Oncol, 2017 Dec 08; 11(1). PMID: 29216508    Free PMC article.
Radiomics in precision medicine for lung cancer.
Julie Constanzo, Lise Wei, Huan-Hsin Tseng, Issam El Naqa.
Transl Lung Cancer Res, 2017 Dec 09; 6(6). PMID: 29218267    Free PMC article.
Review.
Anatomic, functional and molecular imaging in lung cancer precision radiation therapy: treatment response assessment and radiation therapy personalization.
Michael MacManus, Sarah Everitt, +3 authors, Feng-Ming Spring Kong.
Transl Lung Cancer Res, 2017 Dec 09; 6(6). PMID: 29218270    Free PMC article.
Review.
Fractal-based radiomic approach to predict complete pathological response after chemo-radiotherapy in rectal cancer.
Davide Cusumano, Nicola Dinapoli, +12 authors, Vincenzo Valentini.
Radiol Med, 2017 Dec 13; 123(4). PMID: 29230678
Predicting survival time of lung cancer patients using radiomic analysis.
Ahmad Chaddad, Christian Desrosiers, Matthew Toews, Bassam Abdulkarim.
Oncotarget, 2017 Dec 22; 8(61). PMID: 29262648    Free PMC article.
Radiomic analysis in contrast-enhanced CT: predict treatment response to chemoradiotherapy in esophageal carcinoma.
Zhen Hou, Wei Ren, +4 authors, Suiren Wan.
Oncotarget, 2017 Dec 22; 8(61). PMID: 29262652    Free PMC article.
Accounting for reconstruction kernel-induced variability in CT radiomic features using noise power spectra.
Muhammad Shafiq-Ul-Hassan, Geoffrey G Zhang, +4 authors, Eduardo G Moros.
J Med Imaging (Bellingham), 2017 Dec 30; 5(1). PMID: 29285518    Free PMC article.
Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL.
Adam Olshen, Denise Wolf, +10 authors, Catherine C Park.
J Med Imaging (Bellingham), 2018 Jan 04; 5(1). PMID: 29296631    Free PMC article.
Towards precision medicine: from quantitative imaging to radiomics.
U Rajendra Acharya, Yuki Hagiwara, +2 authors, Kwan Hoong Ng.
J Zhejiang Univ Sci B, 2018 Jan 09; 19(1). PMID: 29308604    Free PMC article.
Review.
Can CT-based radiomics signature predict KRAS/NRAS/BRAF mutations in colorectal cancer?
Lei Yang, Di Dong, +7 authors, Jie Tian.
Eur Radiol, 2018 Jan 18; 28(5). PMID: 29335867
Highly Cited.
Effect of tube current on computed tomography radiomic features.
Dennis Mackin, Rachel Ger, +8 authors, Laurence Court.
Sci Rep, 2018 Feb 07; 8(1). PMID: 29403060    Free PMC article.
Pre-treatment magnetic resonance-based texture features as potential imaging biomarkers for predicting event free survival in anal cancer treated by chemoradiotherapy.
Arnaud Hocquelet, Thibaut Auriac, +7 authors, Véronique Vendrely.
Eur Radiol, 2018 Feb 07; 28(7). PMID: 29404766
Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study.
Ralph Th Leijenaar, Marta Bogowicz, +14 authors, Philippe Lambin.
Br J Radiol, 2018 Feb 17; 91(1086). PMID: 29451412    Free PMC article.
18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC) - A prospective externally validated study.
Sara Carvalho, Ralph T H Leijenaar, +6 authors, Philippe Lambin.
PLoS One, 2018 Mar 02; 13(3). PMID: 29494598    Free PMC article.
The crucial role of multiomic approach in cancer research and clinically relevant outcomes.
Miaolong Lu, Xianquan Zhan.
EPMA J, 2018 Mar 09; 9(1). PMID: 29515689    Free PMC article.
Highly Cited. Review.
Data Analysis Strategies in Medical Imaging.
Chintan Parmar, Joseph D Barry, +2 authors, Hugo J W L Aerts.
Clin Cancer Res, 2018 Mar 28; 24(15). PMID: 29581134    Free PMC article.
Review.
Identification of high-risk plaque features in intracranial atherosclerosis: initial experience using a radiomic approach.
Zhang Shi, Chengcheng Zhu, +10 authors, Qi Liu.
Eur Radiol, 2018 Apr 11; 28(9). PMID: 29633002    Free PMC article.
Artificial intelligence in radiology.
Ahmed Hosny, Chintan Parmar, +2 authors, Hugo J W L Aerts.
Nat Rev Cancer, 2018 May 20; 18(8). PMID: 29777175    Free PMC article.
Highly Cited. Review.
The predictive value of CT-based radiomics in differentiating indolent from invasive lung adenocarcinoma in patients with pulmonary nodules.
Yunlang She, Lei Zhang, +9 authors, Chang Chen.
Eur Radiol, 2018 Jun 06; 28(12). PMID: 29869172
Radiomics for Response and Outcome Assessment for Non-Small Cell Lung Cancer.
Liting Shi, Yaoyao He, +4 authors, Yi Rong.
Technol Cancer Res Treat, 2018 Jun 27; 17. PMID: 29940810    Free PMC article.
Review.
Voxel size and gray level normalization of CT radiomic features in lung cancer.
Muhammad Shafiq-Ul-Hassan, Kujtim Latifi, +3 authors, Eduardo Moros.
Sci Rep, 2018 Jul 14; 8(1). PMID: 30002441    Free PMC article.
Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis.
Shih-Ying Huang, Benjamin L Franc, +11 authors, Youngho Seo.
NPJ Breast Cancer, 2018 Aug 23; 4. PMID: 30131973    Free PMC article.
Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings.
Gregory Penzias, Asha Singanamalli, +13 authors, Anant Madabhushi.
PLoS One, 2018 Sep 01; 13(8). PMID: 30169514    Free PMC article.
Texture features and pharmacokinetic parameters in differentiating benign and malignant breast lesions by dynamic contrast enhanced magnetic resonance imaging.
Qingliang Niu, Xiaomei Jiang, +4 authors, Xuexi Zhang.
Oncol Lett, 2018 Sep 15; 16(4). PMID: 30214595    Free PMC article.
Radiomics signature of computed tomography imaging for prediction of survival and chemotherapeutic benefits in gastric cancer.
Yuming Jiang, Chuanli Chen, +10 authors, Guoxin Li.
EBioMedicine, 2018 Sep 19; 36. PMID: 30224313    Free PMC article.
A radiogenomic dataset of non-small cell lung cancer.
Shaimaa Bakr, Olivier Gevaert, +14 authors, Sandy Napel.
Sci Data, 2018 Oct 17; 5. PMID: 30325352    Free PMC article.
Peritumoral radiomics features predict distant metastasis in locally advanced NSCLC.
Tai H Dou, Thibaud P Coroller, +2 authors, Hugo J W L Aerts.
PLoS One, 2018 Nov 06; 13(11). PMID: 30388114    Free PMC article.
Radiomics and liquid biopsy in oncology: the holons of systems medicine.
Emanuele Neri, Marzia Del Re, +4 authors, Romano Danesi.
Insights Imaging, 2018 Nov 16; 9(6). PMID: 30430428    Free PMC article.
Review.
Feasibility of CT radiomics to predict treatment response of individual liver metastases in esophagogastric cancer patients.
Remy Klaassen, Ruben T H M Larue, +4 authors, Hanneke W M van Laarhoven.
PLoS One, 2018 Nov 16; 13(11). PMID: 30440002    Free PMC article.
A radiomic approach for adaptive radiotherapy in non-small cell lung cancer patients.
Sara Ramella, Michele Fiore, +10 authors, Paolo Soda.
PLoS One, 2018 Nov 22; 13(11). PMID: 30462705    Free PMC article.
Unsupervised machine learning of radiomic features for predicting treatment response and overall survival of early stage non-small cell lung cancer patients treated with stereotactic body radiation therapy.
Hongming Li, Maya Galperin-Aizenberg, +2 authors, Yong Fan.
Radiother Oncol, 2018 Nov 27; 129(2). PMID: 30473058    Free PMC article.
Comparison of prediction models with radiological semantic features and radiomics in lung cancer diagnosis of the pulmonary nodules: a case-control study.
Wei Wu, Larry A Pierce, +8 authors, Paul E Kinahan.
Eur Radiol, 2019 May 23; 29(11). PMID: 31115618    Free PMC article.
Towards clinical application of image mining: a systematic review on artificial intelligence and radiomics.
Martina Sollini, Lidija Antunovic, Arturo Chiti, Margarita Kirienko.
Eur J Nucl Med Mol Imaging, 2019 Jun 20; 46(13). PMID: 31214791    Free PMC article.
Systematic Review.
AI-based applications in hybrid imaging: how to build smart and truly multi-parametric decision models for radiomics.
Isabella Castiglioni, Francesca Gallivanone, +5 authors, Marco Salvatore.
Eur J Nucl Med Mol Imaging, 2019 Jul 12; 46(13). PMID: 31292700
Review.
Radiomics and Texture Analysis in Laryngeal Cancer. Looking for New Frontiers in Precision Medicine through Imaging Analysis.
Carlos Miguel Chiesa-Estomba, Oier Echaniz, +3 authors, Manuel Graña.
Cancers (Basel), 2019 Sep 25; 11(10). PMID: 31547210    Free PMC article.
Review.
Radiomics-based predictive risk score: A scoring system for preoperatively predicting risk of lymph node metastasis in patients with resectable non-small cell lung cancer.
Lan He, Yanqi Huang, +3 authors, Zaiyi Liu.
Chin J Cancer Res, 2019 Oct 01; 31(4). PMID: 31564807    Free PMC article.
A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy.
Georgios Kaissis, Sebastian Ziegelmayer, +10 authors, Rickmer Braren.
PLoS One, 2019 Oct 03; 14(10). PMID: 31577805    Free PMC article.
A machine learning based delta-radiomics process for early prediction of treatment response of pancreatic cancer.
Haidy Nasief, Cheng Zheng, +4 authors, X Allen Li.
NPJ Precis Oncol, 2019 Oct 12; 3. PMID: 31602401    Free PMC article.
Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.
Olivier Morin, William C Chen, +22 authors, David R Raleigh.
Neurooncol Adv, 2019 Oct 15; 1(1). PMID: 31608329    Free PMC article.
Technical Note: Proof of concept for radiomics-based quality assurance for computed tomography.
Luciano R F Branco, Rachel B Ger, +3 authors, Rick R Layman.
J Appl Clin Med Phys, 2019 Oct 15; 20(11). PMID: 31609076    Free PMC article.
CT radiomic features for predicting resectability of oesophageal squamous cell carcinoma as given by feature analysis: a case control study.
Jing Ou, Rui Li, +11 authors, Jiani Hu.
Cancer Imaging, 2019 Oct 18; 19(1). PMID: 31619297    Free PMC article.
Distributed radiomics as a signature validation study using the Personal Health Train infrastructure.
Zhenwei Shi, Ivan Zhovannik, +9 authors, Leonard Wee.
Sci Data, 2019 Oct 24; 6(1). PMID: 31641134    Free PMC article.
Radiomics features on radiotherapy treatment planning CT can predict patient survival in locally advanced rectal cancer patients.
Jiazhou Wang, Lijun Shen, +6 authors, Zhen Zhang.
Sci Rep, 2019 Oct 28; 9(1). PMID: 31653909    Free PMC article.
Technical Note: Ontology-guided radiomics analysis workflow (O-RAW).
Zhenwei Shi, Alberto Traverso, +2 authors, Leonard Wee.
Med Phys, 2019 Oct 04; 46(12). PMID: 31580484    Free PMC article.
Establishment of a new non-invasive imaging prediction model for liver metastasis in colon cancer.
Yu Li, Aydin Eresen, +7 authors, Zhuoli Zhang.
Am J Cancer Res, 2019 Dec 10; 9(11). PMID: 31815048    Free PMC article.
Radiomics in stratification of pancreatic cystic lesions: Machine learning in action.
Vipin Dalal, Joseph Carmicheal, +3 authors, Surinder K Batra.
Cancer Lett, 2019 Oct 21; 469. PMID: 31629933    Free PMC article.
Review.
The effects of volume of interest delineation on MRI-based radiomics analysis: evaluation with two disease groups.
Xiao Zhang, Liming Zhong, +6 authors, Qianjin Feng.
Cancer Imaging, 2019 Dec 23; 19(1). PMID: 31864421    Free PMC article.
Quantitative MRI Biomarkers of Stereotactic Radiotherapy Outcome in Brain Metastasis.
Elham Karami, Hany Soliman, +9 authors, Ali Sadeghi-Naini.
Sci Rep, 2019 Dec 29; 9(1). PMID: 31882597    Free PMC article.
Application of radiomics signature captured from pretreatment thoracic CT to predict brain metastases in stage III/IV ALK-positive non-small cell lung cancer patients.
Xinyan Xu, Lyu Huang, +5 authors, Min Fan.
J Thorac Dis, 2020 Jan 07; 11(11). PMID: 31903240    Free PMC article.
CT-based radiomics for prediction of histologic subtype and metastatic disease in primary malignant lung neoplasms.
José Raniery Ferreira-Junior, Marcel Koenigkam-Santos, +6 authors, Paulo Mazzoncini de Azevedo-Marques.
Int J Comput Assist Radiol Surg, 2019 Nov 14; 15(1). PMID: 31722085
Impact of contouring variability on oncological PET radiomics features in the lung.
F Yang, G Simpson, +3 authors, L Wang.
Sci Rep, 2020 Jan 17; 10(1). PMID: 31941949    Free PMC article.
Improving Treatment Response Prediction for Chemoradiation Therapy of Pancreatic Cancer Using a Combination of Delta-Radiomics and the Clinical Biomarker CA19-9.
Haidy Nasief, William Hall, +4 authors, X Allen Li.
Front Oncol, 2020 Jan 24; 9. PMID: 31970088    Free PMC article.
Artificial intelligence, machine learning, computer-aided diagnosis, and radiomics: advances in imaging towards to precision medicine.
Marcel Koenigkam Santos, José Raniery Ferreira Júnior, +3 authors, Paulo Mazzoncini de Azevedo Marques.
Radiol Bras, 2020 Feb 13; 52(6). PMID: 32047333    Free PMC article.
Review.
Prediction of Radiation Pneumonitis With Dose Distribution: A Convolutional Neural Network (CNN) Based Model.
Bin Liang, Yuan Tian, +6 authors, Jianrong Dai.
Front Oncol, 2020 Feb 23; 9. PMID: 32076596    Free PMC article.
Prediction of Treatment Response to Neoadjuvant Chemotherapy for Breast Cancer via Early Changes in Tumor Heterogeneity Captured by DCE-MRI Registration.
Nariman Jahani, Eric Cohen, +6 authors, Despina Kontos.
Sci Rep, 2019 Aug 23; 9(1). PMID: 31431633    Free PMC article.
Objective risk stratification of prostate cancer using machine learning and radiomics applied to multiparametric magnetic resonance images.
Bino Varghese, Frank Chen, +8 authors, Gaurav Pandey.
Sci Rep, 2019 Feb 09; 9(1). PMID: 30733585    Free PMC article.
The complexity of tumor shape, spiculatedness, correlates with tumor radiomic shape features.
Elaine Johanna Limkin, Sylvain Reuzé, +6 authors, Charlotte Robert.
Sci Rep, 2019 Mar 15; 9(1). PMID: 30867443    Free PMC article.
Revealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness.
Dmitry Cherezov, Dmitry Goldgof, +4 authors, Adrien Depeursinge.
Sci Rep, 2019 Mar 16; 9(1). PMID: 30872600    Free PMC article.
The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective.
Robert H Press, Hui-Kuo G Shu, +23 authors, John M Buatti.
Int J Radiat Oncol Biol Phys, 2018 Jul 04; 102(4). PMID: 29966725    Free PMC article.
Review.
Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study.
Ahmed Hosny, Chintan Parmar, +7 authors, Hugo J W L Aerts.
PLoS Med, 2018 Dec 01; 15(11). PMID: 30500819    Free PMC article.
Highly Cited.
Perinodular and Intranodular Radiomic Features on Lung CT Images Distinguish Adenocarcinomas from Granulomas.
Niha Beig, Mohammadhadi Khorrami, +16 authors, Anant Madabhushi.
Radiology, 2018 Dec 19; 290(3). PMID: 30561278    Free PMC article.
Highly Cited.
Therapeutic decision based on molecular detection of resistance mechanism in an ALK-rearranged lung cancer patient: a case report.
Elisa De Carlo, Monica Schiappacassi, +8 authors, Alessandra Bearz.
Onco Targets Ther, 2018 Dec 24; 11. PMID: 30573982    Free PMC article.
Radiomic signature of 18F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits.
Yuming Jiang, Qingyu Yuan, +13 authors, Guoxin Li.
Theranostics, 2019 Jan 08; 8(21). PMID: 30613271    Free PMC article.
Radiomics Analysis of PET and CT Components of PET/CT Imaging Integrated with Clinical Parameters: Application to Prognosis for Nasopharyngeal Carcinoma.
Wenbing Lv, Qingyu Yuan, +5 authors, Lijun Lu.
Mol Imaging Biol, 2019 Jan 24; 21(5). PMID: 30671740
IDH mutation-specific radiomic signature in lower-grade gliomas.
Xing Liu, Yiming Li, +9 authors, Yinyan Wang.
Aging (Albany NY), 2019 Jan 31; 11(2). PMID: 30696801    Free PMC article.
NCTN Assessment on Current Applications of Radiomics in Oncology.
Ke Nie, Hania Al-Hallaq, +15 authors, Issam El Naqa.
Int J Radiat Oncol Biol Phys, 2019 Feb 04; 104(2). PMID: 30711529    Free PMC article.
Review.
Artificial intelligence in cancer imaging: Clinical challenges and applications.
Wenya Linda Bi, Ahmed Hosny, +16 authors, Hugo J W L Aerts.
CA Cancer J Clin, 2019 Feb 06; 69(2). PMID: 30720861    Free PMC article.
Highly Cited. Review.
RaCaT: An open source and easy to use radiomics calculator tool.
Elisabeth Pfaehler, Alex Zwanenburg, Johan R de Jong, Ronald Boellaard.
PLoS One, 2019 Feb 21; 14(2). PMID: 30785937    Free PMC article.
Deep learning in head & neck cancer outcome prediction.
André Diamant, Avishek Chatterjee, +2 authors, Jan Seuntjens.
Sci Rep, 2019 Feb 28; 9(1). PMID: 30809047    Free PMC article.
MRI-based Radiomics nomogram to detect primary rectal cancer with synchronous liver metastases.
Zhenyu Shu, Songhua Fang, +5 authors, Xiangyang Gong.
Sci Rep, 2019 Mar 06; 9(1). PMID: 30833648    Free PMC article.
The Applications of Radiomics in Precision Diagnosis and Treatment of Oncology: Opportunities and Challenges.
Zhenyu Liu, Shuo Wang, +8 authors, Jie Tian.
Theranostics, 2019 Mar 15; 9(5). PMID: 30867832    Free PMC article.
Highly Cited. Review.
Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging.
Yiwen Xu, Ahmed Hosny, +5 authors, Hugo J W L Aerts.
Clin Cancer Res, 2019 Apr 24; 25(11). PMID: 31010833    Free PMC article.
Highly Cited.
Longitudinal radiomics of cone-beam CT images from non-small cell lung cancer patients: Evaluation of the added prognostic value for overall survival and locoregional recurrence.
Janna E van Timmeren, Wouter van Elmpt, +11 authors, Philippe Lambin.
Radiother Oncol, 2019 Apr 25; 136. PMID: 31015133    Free PMC article.
Nf1 loss promotes Kras-driven lung adenocarcinoma and results in Psat1-mediated glutamate dependence.
Xiaojing Wang, Shengping Min, +10 authors, Yuqing Chen.
EMBO Mol Med, 2019 May 01; 11(6). PMID: 31036704    Free PMC article.
Radiomic feature stability across 4D respiratory phases and its impact on lung tumor prognosis prediction.
Qian Du, Michael Baine, +9 authors, Dandan Zheng.
PLoS One, 2019 May 08; 14(5). PMID: 31063500    Free PMC article.
Design and fabrication of heterogeneous lung nodule phantoms for assessing the accuracy and variability of measured texture radiomics features in CT.
Ehsan Samei, Jocelyn Hoye, +2 authors, Daniele Marin.
J Med Imaging (Bellingham), 2019 Jul 03; 6(2). PMID: 31263737    Free PMC article.
Segmentation and Classification in Digital Pathology for Glioma Research: Challenges and Deep Learning Approaches.
Tahsin Kurc, Spyridon Bakas, +21 authors, Keyvan Farahani.
Front Neurosci, 2020 Mar 11; 14. PMID: 32153349    Free PMC article.
Multiparametric radiomics methods for breast cancer tissue characterization using radiological imaging.
Vishwa S Parekh, Michael A Jacobs.
Breast Cancer Res Treat, 2020 Feb 06; 180(2). PMID: 32020435    Free PMC article.
Cardiac magnetic resonance radiomics: basic principles and clinical perspectives.
Zahra Raisi-Estabragh, Cristian Izquierdo, +5 authors, Steffen E Petersen.
Eur Heart J Cardiovasc Imaging, 2020 Mar 07; 21(4). PMID: 32142107    Free PMC article.
Systematic analysis of bias and variability of morphologic features for lung lesions in computed tomography.
Jocelyn Hoye, Justin Solomon, +2 authors, Ehsan Samei.
J Med Imaging (Bellingham), 2019 Apr 05; 6(1). PMID: 30944842    Free PMC article.
Radiomics signature: a biomarker for the preoperative discrimination of lung invasive adenocarcinoma manifesting as a ground-glass nodule.
Li Fan, MengJie Fang, +6 authors, ShiYuan Liu.
Eur Radiol, 2018 Jul 04; 29(2). PMID: 29967956
Predicting the grade of hepatocellular carcinoma based on non-contrast-enhanced MRI radiomics signature.
Minghui Wu, Hongna Tan, +7 authors, Dapeng Shi.
Eur Radiol, 2018 Nov 09; 29(6). PMID: 30406313
Preoperative radiomic signature based on multiparametric magnetic resonance imaging for noninvasive evaluation of biological characteristics in rectal cancer.
Xiaochun Meng, Wei Xia, +12 authors, Xin Gao.
Eur Radiol, 2018 Nov 11; 29(6). PMID: 30413959
Adaptive statistical iterative reconstruction (ASIR) affects CT radiomics quantification in primary colorectal cancer.
Davide Prezzi, Katarzyna Owczarczyk, +4 authors, Vicky Goh.
Eur Radiol, 2019 Mar 20; 29(10). PMID: 30887205    Free PMC article.
Cone-beam CT radiomics features might improve the prediction of lung toxicity after SBRT in stage I NSCLC patients.
Qingjin Qin, Anhui Shi, +7 authors, Ligang Xing.
Thorac Cancer, 2020 Feb 16; 11(4). PMID: 32061061    Free PMC article.
Radiomics robustness assessment and classification evaluation: A two-stage method demonstrated on multivendor FFDM.
Kayla Robinson, Hui Li, +2 authors, Maryellen Giger.
Med Phys, 2019 Feb 26; 46(5). PMID: 30802972    Free PMC article.
A radiomics approach based on support vector machine using MR images for preoperative lymph node status evaluation in intrahepatic cholangiocarcinoma.
Lei Xu, Pengfei Yang, +9 authors, Tianye Niu.
Theranostics, 2019 Aug 15; 9(18). PMID: 31410221    Free PMC article.
Predicting locally advanced rectal cancer response to neoadjuvant therapy with 18F-FDG PET and MRI radiomics features.
V Giannini, S Mazzetti, +11 authors, D Regge.
Eur J Nucl Med Mol Imaging, 2019 Jan 15; 46(4). PMID: 30637502
Integrative Radiogenomics Approach for Risk Assessment of Post-Operative Metastasis in Pathological T1 Renal Cell Carcinoma: A Pilot Retrospective Cohort Study.
Hye Won Lee, Hwan-Ho Cho, +9 authors, Hyunjin Park.
Cancers (Basel), 2020 Apr 08; 12(4). PMID: 32252440    Free PMC article.
Radiomics Analysis of MRI for Predicting Molecular Subtypes of Breast Cancer in Young Women.
Qinmei Li, James Dormer, +3 authors, Baowei Fei.
Proc SPIE Int Soc Opt Eng, 2019 Feb 01; 10950. PMID: 32528211    Free PMC article.
Multisite evaluation of radiomic feature reproducibility and discriminability for identifying peripheral zone prostate tumors on MRI.
Prathyush Chirra, Patrick Leo, +6 authors, Satish E Viswanath.
J Med Imaging (Bellingham), 2019 Jul 02; 6(2). PMID: 31259199    Free PMC article.
Radiomics Prediction of EGFR Status in Lung Cancer-Our Experience in Using Multiple Feature Extractors and The Cancer Imaging Archive Data.
Lin Lu, Shawn H Sun, +4 authors, Binsheng Zhao.
Tomography, 2020 Jun 18; 6(2). PMID: 32548300    Free PMC article.
Diagnosis of triple negative breast cancer based on radiomics signatures extracted from preoperative contrast-enhanced chest computed tomography.
Qingliang Feng, Qiang Hu, +2 authors, Ziyi Yin.
BMC Cancer, 2020 Jun 24; 20(1). PMID: 32571245    Free PMC article.
Using CT texture analysis to differentiate between peripheral lung cancer and pulmonary inflammatory pseudotumor.
Chenlu Liu, Changsheng Ma, +4 authors, Yong Yin.
BMC Med Imaging, 2020 Jul 08; 20(1). PMID: 32631330    Free PMC article.
Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy.
Stuart L Polk, Jung W Choi, +10 authors, Daniel Jeong.
World J Gastroenterol, 2020 Jul 14; 26(24). PMID: 32655269    Free PMC article.
Current Landscape of Breast Cancer Imaging and Potential Quantitative Imaging Markers of Response in ER-Positive Breast Cancers Treated with Neoadjuvant Therapy.
Ella F Jones, Deep K Hathi, +6 authors, Nola M Hylton.
Cancers (Basel), 2020 Jun 13; 12(6). PMID: 32527022    Free PMC article.
Review.
Radiomics: from qualitative to quantitative imaging.
William Rogers, Sithin Thulasi Seetha, +14 authors, Philippe Lambin.
Br J Radiol, 2020 Feb 27; 93(1108). PMID: 32101448    Free PMC article.
Review.
Radiomics of Coronary Artery Calcium in the Framingham Heart Study.
Parastou Eslami, Chintan Parmar, +13 authors, Udo Hoffmann.
Radiol Cardiothorac Imaging, 2020 Jul 28; 2(1). PMID: 32715301    Free PMC article.
Overview of radiomics in breast cancer diagnosis and prognostication.
Alberto Stefano Tagliafico, Michele Piana, +3 authors, Nehmat Houssami.
Breast, 2019 Nov 19; 49. PMID: 31739125    Free PMC article.
Review.
Radiomics as a personalized medicine tool in lung cancer: Separating the hope from the hype.
Isabella Fornacon-Wood, Corinne Faivre-Finn, James P B O'Connor, Gareth J Price.
Lung Cancer, 2020 Jun 21; 146. PMID: 32563015    Free PMC article.
Review.
Overall Survival Prediction in Glioblastoma With Radiomic Features Using Machine Learning.
Ujjwal Baid, Swapnil U Rane, +4 authors, Abhishek Mahajan.
Front Comput Neurosci, 2020 Aug 28; 14. PMID: 32848682    Free PMC article.
Survival prediction for oral tongue cancer patients via probabilistic genetic algorithm optimized neural network models.
Xiaoying Pan, Ting Zhang, +3 authors, X Sharon Qi.
Br J Radiol, 2020 Jun 11; 93(1112). PMID: 32520585    Free PMC article.
Clinical value of texture analysis in differentiation of urothelial carcinoma based on multiphase computed tomography images.
Zihua Wang, Yufang He, +4 authors, Lei Mo.
Medicine (Baltimore), 2020 May 03; 99(18). PMID: 32358396    Free PMC article.
Radiomics Nomogram for Prediction of Peritoneal Metastasis in Patients With Gastric Cancer.
Weicai Huang, Kangneng Zhou, +13 authors, Guoxin Li.
Front Oncol, 2020 Sep 26; 10. PMID: 32974149    Free PMC article.
The Feasibility Study of Megavoltage Computed Tomographic (MVCT) Image for Texture Feature Analysis.
Jiabing Gu, Jian Zhu, +4 authors, Yong Yin.
Front Oncol, 2018 Dec 21; 8. PMID: 30568918    Free PMC article.
Radiomics - the value of the numbers in present and future radiology.
Mateusz Patyk, Jurand Silicki, +3 authors, Urszula Zaleska-Dorobisz.
Pol J Radiol, 2019 Jan 11; 83. PMID: 30627231    Free PMC article.
Review.
Optimal respiratory-gated [18F]FDG PET/CT significantly impacts the quantification of metabolic parameters and their correlation with overall survival in patients with pancreatic ductal adenocarcinoma.
Esther M M Smeets, Dominique S Withaar, +5 authors, Erik H J G Aarntzen.
EJNMMI Res, 2019 Mar 15; 9(1). PMID: 30868318    Free PMC article.
Application of computed tomography-based radiomics signature analysis in the prediction of the response of small cell lung cancer patients to first-line chemotherapy.
Haifeng Wei, Fengchang Yang, +7 authors, Ximing Wang.
Exp Ther Med, 2019 Apr 17; 17(5). PMID: 30988745    Free PMC article.
Reproducibility and non-redundancy of radiomic features extracted from arterial phase CT scans in hepatocellular carcinoma patients: impact of tumor segmentation variability.
Qingtao Qiu, Jinghao Duan, +6 authors, Yong Yin.
Quant Imaging Med Surg, 2019 Apr 30; 9(3). PMID: 31032192    Free PMC article.
Radiomics Signature on Computed Tomography Imaging: Association With Lymph Node Metastasis in Patients With Gastric Cancer.
Yuming Jiang, Wei Wang, +12 authors, Guoxin Li.
Front Oncol, 2019 May 21; 9. PMID: 31106158    Free PMC article.
An image-based deep learning framework for individualizing radiotherapy dose.
Bin Lou, Semihcan Doken, +6 authors, Mohamed E Abazeed.
Lancet Digit Health, 2019 Aug 27; 1(3). PMID: 31448366    Free PMC article.
Image-based simulation and modeling: unlocking small airway function tests?
Alex Bell, Salman Siddiqui.
J Appl Physiol (1985), 2020 Jul 24; 129(3). PMID: 32702265    Free PMC article.
Exploratory Study of a CT Radiomics Model for the Classification of Small Cell Lung Cancer and Non-small-Cell Lung Cancer.
Shihe Liu, Shunli Liu, +6 authors, Qing Fu.
Front Oncol, 2020 Oct 06; 10. PMID: 33014770    Free PMC article.
Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.
Chunhao Wang, Chenyang Liu, +7 authors, Fang-Fang Yin.
Front Oncol, 2020 Oct 06; 10. PMID: 33014811    Free PMC article.
Non-invasive evaluation for benign and malignant subcentimeter pulmonary ground-glass nodules (≤1 cm) based on CT texture analysis.
Xianghua Hu, Weichuan Ye, +10 authors, Jiansong Ji.
Br J Radiol, 2020 Jul 21; 93(1114). PMID: 32686958    Free PMC article.
Novel, non-invasive imaging approach to identify patients with advanced non-small cell lung cancer at risk of hyperprogressive disease with immune checkpoint blockade.
Pranjal Vaidya, Kaustav Bera, +6 authors, Anant Madabhushi.
J Immunother Cancer, 2020 Oct 15; 8(2). PMID: 33051342    Free PMC article.
Radiomic Analysis of MRI Images is Instrumental to the Stratification of Ovarian Cysts.
Roxana-Adelina Lupean, Paul-Andrei Ștefan, +5 authors, Carmen Mihaela Mihu.
J Pers Med, 2020 Sep 18; 10(3). PMID: 32937851    Free PMC article.
XGBoost Improves Classification of MGMT Promoter Methylation Status in IDH1 Wildtype Glioblastoma.
Nguyen Quoc Khanh Le, Duyen Thi Do, +3 authors, Cheng-Yu Chen.
J Pers Med, 2020 Sep 19; 10(3). PMID: 32942564    Free PMC article.
Differentiating Hepatic Epithelioid Angiomyolipoma From Hepatocellular Carcinoma and Focal Nodular Hyperplasia via Radiomics Models.
Wenjie Liang, Jiayuan Shao, +7 authors, Wenbo Xiao.
Front Oncol, 2020 Oct 31; 10. PMID: 33123475    Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
[Research Advances and Obstacles of CT-based Radiomics in Diagnosis and Treatment of Lung Cancer].
Jiawei Li, Xiadong Li, Xueqin Chen, Shenglin Ma.
Zhongguo Fei Ai Za Zhi, 2020 Aug 18; 23(10). PMID: 32798440    Free PMC article.
[A radiomics-based model for differentiation between benign and malignant gastrointestinal stromal tumors].
Wenhua Zhang, Tao Chen, +2 authors, Zhentai Lu.
Nan Fang Yi Ke Da Xue Xue Bao, 2018 Jan 30; 38(1). PMID: 33177032    Free PMC article.
The Current State of Radiomics for Meningiomas: Promises and Challenges.
Hao Gu, Xu Zhang, +2 authors, Tao Xu.
Front Oncol, 2020 Nov 17; 10. PMID: 33194649    Free PMC article.
Review.
RADIO-IBAG: RADIOMICS-BASED INTEGRATIVE BAYESIAN ANALYSIS OF MULTIPLATFORM GENOMIC DATA.
Youyi Zhang, Jeffrey S Morris, +2 authors, Veerabhadran Baladandayuthapani.
Ann Appl Stat, 2019 Jan 01; 13(3). PMID: 33224404    Free PMC article.
Radiomics Signatures of Cardiovascular Risk Factors in Cardiac MRI: Results From the UK Biobank.
Irem Cetin, Zahra Raisi-Estabragh, +6 authors, Karim Lekadir.
Front Cardiovasc Med, 2020 Nov 27; 7. PMID: 33240940    Free PMC article.
Can Magnetic Resonance Radiomics Analysis Discriminate Parotid Gland Tumors? A Pilot Study.
Michela Gabelloni, Lorenzo Faggioni, +9 authors, Emanuele Neri.
Diagnostics (Basel), 2020 Nov 07; 10(11). PMID: 33153140    Free PMC article.
[Radiomics: Big Data Instead of Biopsies in the Future?]
Kathrin Scheckenbach.
Laryngorhinootologie, 2018 Jun 16; 97(S 01). PMID: 29905355    Free PMC article.
Review.
A review on radiomics and the future of theranostics for patient selection in precision medicine.
Simon A Keek, Ralph Th Leijenaar, Arthur Jochems, Henry C Woodruff.
Br J Radiol, 2018 Jun 28; 91(1091). PMID: 29947266    Free PMC article.
Review.
Development and validation of a magnetic resonance imaging-based model for the prediction of distant metastasis before initial treatment of nasopharyngeal carcinoma: A retrospective cohort study.
Lu Zhang, Di Dong, +12 authors, Shuixing Zhang.
EBioMedicine, 2019 Jan 16; 40. PMID: 30642750    Free PMC article.
Radiomic analysis of planning computed tomograms for predicting radiation-induced lung injury and outcome in lung cancer patients treated with robotic stereotactic body radiation therapy.
Khaled Bousabarah, Susanne Temming, +7 authors, Harald Treuer.
Strahlenther Onkol, 2019 Mar 16; 195(9). PMID: 30874846
Prediction early recurrence of hepatocellular carcinoma eligible for curative ablation using a Radiomics nomogram.
Chunwang Yuan, Zhenchang Wang, +10 authors, Jiliang Feng.
Cancer Imaging, 2019 Apr 28; 19(1). PMID: 31027510    Free PMC article.
Prediction of pathologic stage in non-small cell lung cancer using machine learning algorithm based on CT image feature analysis.
Lingming Yu, Guangyu Tao, +4 authors, Qunhui Chen.
BMC Cancer, 2019 May 19; 19(1). PMID: 31101024    Free PMC article.
Radiomics model for distinguishing tuberculosis and lung cancer on computed tomography scans.
E-Nuo Cui, Tao Yu, +6 authors, Xi-Ran Jiang.
World J Clin Cases, 2020 Dec 04; 8(21). PMID: 33269256    Free PMC article.
Repeatability of Cardiac Magnetic Resonance Radiomics: A Multi-Centre Multi-Vendor Test-Retest Study.
Zahra Raisi-Estabragh, Polyxeni Gkontra, +10 authors, Steffen E Petersen.
Front Cardiovasc Med, 2020 Dec 22; 7. PMID: 33344517    Free PMC article.
Identifying Cross-Scale Associations between Radiomic and Pathomic Signatures of Non-Small Cell Lung Cancer Subtypes: Preliminary Results.
Charlems Alvarez-Jimenez, Alvaro A Sandino, +3 authors, Eduardo Romero.
Cancers (Basel), 2020 Dec 11; 12(12). PMID: 33297357    Free PMC article.
Radiomics Feature Activation Maps as a New Tool for Signature Interpretability.
Diem Vuong, Stephanie Tanadini-Lang, +9 authors, Marta Bogowicz.
Front Oncol, 2020 Dec 29; 10. PMID: 33364192    Free PMC article.
Machine Learning Methods for Optimal Radiomics-Based Differentiation Between Recurrence and Inflammation: Application to Nasopharyngeal Carcinoma Post-therapy PET/CT Images.
Dongyang Du, Hui Feng, +8 authors, Lijun Lu.
Mol Imaging Biol, 2019 Jul 25; 22(3). PMID: 31338709
Use of relative CT values to evaluate the invasiveness of pulmonary subsolid nodules in patients with emphysema.
Bo-Wei Zhang, Yu Zhang, Jian-Ding Ye, Jin-Wei Qiang.
Quant Imaging Med Surg, 2021 Jan 05; 11(1). PMID: 33392022    Free PMC article.
A Novel Nomogram Model Based on Cone-Beam CT Radiomics Analysis Technology for Predicting Radiation Pneumonitis in Esophageal Cancer Patients Undergoing Radiotherapy.
Feng Du, Ning Tang, +4 authors, Jianbin Li.
Front Oncol, 2021 Jan 05; 10. PMID: 33392091    Free PMC article.
A Radiomics Signature to Quantitatively Analyze COVID-19-Infected Pulmonary Lesions.
Jiajun Qiu, Shaoliang Peng, +5 authors, Wei Zhang.
Interdiscip Sci, 2021 Jan 08;. PMID: 33411162    Free PMC article.
YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas.
Wei Xu, Mingjiong Zhang, +8 authors, Jianqing Wu.
Cancer Cell Int, 2021 Jan 09; 21(1). PMID: 33413409    Free PMC article.
Automatic recognition and analysis of metal streak artifacts in head and neck computed tomography for radiomics modeling.
Lise Wei, Benjamin Rosen, +4 authors, Issam El Naqa.
Phys Imaging Radiat Oncol, 2019 Jun 06; 10. PMID: 33458268    Free PMC article.
Preoperatively Estimating the Malignant Potential of Mediastinal Lymph Nodes: A Pilot Study Toward Establishing a Robust Radiomics Model Based on Contrast-Enhanced CT Imaging.
Mengshi Dong, Gang Hou, +3 authors, Ke Xu.
Front Oncol, 2021 Jan 26; 10. PMID: 33489871    Free PMC article.
Radiomics in lung cancer for oncologists.
Carolina de la Pinta, Nuria Barrios-Campo, David Sevillano.
J Clin Transl Res, 2021 Feb 02; 6(4). PMID: 33521373    Free PMC article.
Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis.
Yexun Song, Wenfang Tang, Hui Li.
Biosci Rep, 2021 Jan 06; 41(1). PMID: 33398330    Free PMC article.
Radiomics signature on CECT as a predictive factor for invasiveness of lung adenocarcinoma manifesting as subcentimeter ground glass nodules.
Wufei Chen, Ming Li, +9 authors, Hao Wu.
Sci Rep, 2021 Feb 13; 11(1). PMID: 33574448    Free PMC article.
The Impact of Preoperative Radiomics Signature on the Survival of Breast Cancer Patients With Residual Tumors After NAC.
Ling Zhang, Xinhua Jiang, +5 authors, Li Li.
Front Oncol, 2021 Feb 23; 10. PMID: 33614472    Free PMC article.