. 2015 Mar; 212(4):435-45.
doi: 10.1084/jem.20150295.

The interaction of anticancer therapies with tumor-associated macrophages

Alberto Mantovani 1 Paola Allavena 1 
  • PMID: 25753580
  •     100 References
  •     245 citations


Macrophages are essential components of the inflammatory microenvironment of tumors. Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs, antiangiogenic agents, and immunotherapy, including checkpoint blockade, all profoundly influence or depend on the function of tumor-associated macrophages (TAMs). Chemotherapy and radiotherapy can have dual influences on TAMs in that a misdirected macrophage-orchestrated tissue repair response can result in chemoresistance, but in other circumstances, TAMs are essential for effective therapy. A better understanding of the interaction of anticancer therapies with innate immunity, and TAMs in particular, may pave the way to better patient selection and innovative combinations of conventional approaches with immunotherapy.

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Grazia Carbotti, Gaia Barisione, +6 authors, Silvano Ferrini.
Oncotarget, 2015 Dec 15; 6(41). PMID: 26657115    Free PMC article.
Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.
Anders Olsson, Jessica Nakhlé, +9 authors, Tomas Leanderson.
J Immunother Cancer, 2015 Dec 18; 3. PMID: 26673090    Free PMC article.
Biological interactions of carbon-based nanomaterials: From coronation to degradation.
Kunal Bhattacharya, Sourav P Mukherjee, +6 authors, Bengt Fadeel.
Nanomedicine, 2015 Dec 29; 12(2). PMID: 26707820    Free PMC article.
Glypican-3 is a prognostic factor and an immunotherapeutic target in hepatocellular carcinoma.
Yukihiro Haruyama, Hiroaki Kataoka.
World J Gastroenterol, 2016 Jan 13; 22(1). PMID: 26755876    Free PMC article.
Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis.
Keyue Shen, Samantha Luk, +3 authors, Biju Parekkadan.
Sci Rep, 2016 Feb 20; 6. PMID: 26893143    Free PMC article.
Tumor-associated macrophages in gastric cancer: more than bystanders in tumor microenvironment.
Armando Rojas, Fernando Delgado-López, Ileana Gonzalez.
Gastric Cancer, 2016 Feb 20; 20(1). PMID: 26894296
A20 inhibits the motility of HCC cells induced by TNF-α.
Xianteng Wang, Chao Ma, +5 authors, Yongyu Shi.
Oncotarget, 2016 Feb 26; 7(12). PMID: 26909601    Free PMC article.
Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas.
Nahir Cortes-Santiago, Mohammad B Hossain, +8 authors, Candelaria Gomez-Manzano.
Oncotarget, 2016 Feb 26; 7(13). PMID: 26910374    Free PMC article.
Ontogeny of Tumor-associated Macrophages and Its Implication in Cancer Regulation.
Ruth A Franklin, Ming O Li.
Trends Cancer, 2016 Mar 08; 2(1). PMID: 26949745    Free PMC article.
Tumor-associated macrophages and anti-tumor therapies: complex links.
Cristina Belgiovine, Maurizio D'Incalci, Paola Allavena, Roberta Frapolli.
Cell Mol Life Sci, 2016 Mar 10; 73(13). PMID: 26956893
Vaccines for established cancer: overcoming the challenges posed by immune evasion.
Sjoerd H van der Burg, Ramon Arens, +2 authors, Cornelis J M Melief.
Nat Rev Cancer, 2016 Mar 12; 16(4). PMID: 26965076
Highly Cited. Review.
From kinetics and cellular cooperations to cancer immunotherapies.
Alain Trautmann.
Oncotarget, 2016 Mar 26; 7(28). PMID: 27014912    Free PMC article.
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Teresa E Peterson, Nathaniel D Kirkpatrick, +20 authors, Rakesh K Jain.
Proc Natl Acad Sci U S A, 2016 Apr 05; 113(16). PMID: 27044097    Free PMC article.
Highly Cited.
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.
Jonas Kloepper, Lars Riedemann, +24 authors, Rakesh K Jain.
Proc Natl Acad Sci U S A, 2016 Apr 05; 113(16). PMID: 27044098    Free PMC article.
Highly Cited.
Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma.
Shin Foong Ngiow, Katrina M Meeth, +4 authors, Mark J Smyth.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141346    Free PMC article.
Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma.
Giovanni Francesco Castino, Nina Cortese, +14 authors, Federica Marchesi.
Oncoimmunology, 2016 May 04; 5(4). PMID: 27141376    Free PMC article.
Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods.
Lucia Cavigli, Francesca Tatini, +6 authors, Roberto Pini.
J Vis Exp, 2016 May 12; (111). PMID: 27167995    Free PMC article.
Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment.
Manuela Liguori, Chiara Buracchi, +7 authors, Paola Allavena.
Oncotarget, 2016 May 19; 7(27). PMID: 27191500    Free PMC article.
Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases.
Nora Rippaus, David Taggart, +4 authors, Mihaela Lorger.
Oncotarget, 2016 May 21; 7(27). PMID: 27203741    Free PMC article.
Indomethacin sensitizes resistant transformed cells to macrophage cytotoxicity.
Hana Totary-Jain, Ronit Vogt Sionov, Ruth Gallily.
Immunol Lett, 2016 May 24; 176. PMID: 27210423    Free PMC article.
Inverse role of distinct subsets and distribution of macrophage in lung cancer prognosis: a meta-analysis.
Pin Wu, Dang Wu, +5 authors, Ying Chai.
Oncotarget, 2016 Oct 27; 7(26). PMID: 27248173    Free PMC article.
Impaired lymphatic function accelerates cancer growth.
Eli Sihn Samdal Steinskog, Solfrid Johanne Sagstad, +6 authors, Hans Petter Eikesdal.
Oncotarget, 2016 Jun 23; 7(29). PMID: 27329584    Free PMC article.
Positive effect of HPV status on prognostic value of blood lymphocyte-to-monocyte ratio in advanced cervical carcinoma.
Si-Wei Li, Wenxin Yuan, +4 authors, Li-Hua Xu.
Cancer Cell Int, 2016 Jul 07; 16. PMID: 27382361    Free PMC article.
CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas.
Katherine A Murphy, Thomas S Griffith.
Cancers (Basel), 2016 Jul 30; 8(8). PMID: 27472363    Free PMC article.
Cell-cycle-controlled radiation therapy was effective for treating a murine malignant melanoma cell line in vitro and in vivo.
Keisuke Otani, Yoko Naito, +5 authors, Masaru Ishii.
Sci Rep, 2016 Aug 03; 6. PMID: 27480052    Free PMC article.
Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation.
Ana T Pinto, Marta L Pinto, +10 authors, Sónia Rocha.
PLoS One, 2016 Aug 12; 11(8). PMID: 27513864    Free PMC article.
Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages.
Chiara Raggi, Margherita Correnti, +16 authors, Pietro Invernizzi.
J Hepatol, 2016 Sep 07; 66(1). PMID: 27593106    Free PMC article.
Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy.
Masahiro Azuma, Yohei Takeda, +5 authors, Tsukasa Seya.
Oncoimmunology, 2016 Sep 14; 5(8). PMID: 27622060    Free PMC article.
Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors.
Lucy Ireland, Almudena Santos, +13 authors, Ainhoa Mielgo.
Cancer Res, 2016 Oct 16; 76(23). PMID: 27742686    Free PMC article.
Highly Cited.
Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma.
Fang-Zhu Ouyang, Rui-Qi Wu, +7 authors, Dong-Ming Kuang.
Nat Commun, 2016 Nov 18; 7. PMID: 27853178    Free PMC article.
Targeting Inflammation in Cancer Prevention and Therapy.
Jelena Todoric, Laura Antonucci, Michael Karin.
Cancer Prev Res (Phila), 2016 Dec 04; 9(12). PMID: 27913448    Free PMC article.
Highly Cited. Review.
VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.
Valentina Comunanza, Davide Corà, +9 authors, Federico Bussolino.
EMBO Mol Med, 2016 Dec 16; 9(2). PMID: 27974353    Free PMC article.
Context-Specific and Immune Cell-Dependent Antitumor Activities of α1-Antitrypsin.
Ofer Guttman, Gabriella S Freixo-Lima, +3 authors, Eli C Lewis.
Front Immunol, 2016 Dec 23; 7. PMID: 28003813    Free PMC article.
CS2164, a novel multi-target inhibitor against tumor angiogenesis, mitosis and chronic inflammation with anti-tumor potency.
You Zhou, Song Shan, +10 authors, Xian-Ping Lu.
Cancer Sci, 2016 Dec 23; 108(3). PMID: 28004478    Free PMC article.
Nanomedicines for dysfunctional macrophage-associated diseases.
Hongliang He, Shobha Ghosh, Hu Yang.
J Control Release, 2017 Jan 07; 247. PMID: 28057522    Free PMC article.
The Prognostic and Clinicopathological Significance of Tumor-Associated Macrophages in Patients with Gastric Cancer: A Meta-Analysis.
Songcheng Yin, Jinyu Huang, +5 authors, Huimian Xu.
PLoS One, 2017 Jan 13; 12(1). PMID: 28081243    Free PMC article.
Determinants of metastatic competency in colorectal cancer.
Daniele V F Tauriello, Alexandre Calon, Enza Lonardo, Eduard Batlle.
Mol Oncol, 2017 Jan 14; 11(1). PMID: 28085225    Free PMC article.
Hypermethylation of IFN-γ in oral cancer tissues.
Songbo Tian, Chunyang Jiang, +6 authors, Dong Ma.
Clin Oral Investig, 2017 Jan 17; 21(8). PMID: 28091876
Tumour-associated macrophages as treatment targets in oncology.
Alberto Mantovani, Federica Marchesi, +2 authors, Paola Allavena.
Nat Rev Clin Oncol, 2017 Jan 25; 14(7). PMID: 28117416    Free PMC article.
Highly Cited. Review.
Differential distribution of tumor-associated macrophages and Treg/Th17 cells in the progression of malignant and benign epithelial ovarian tumors.
Qinyi Zhu, Xiaoli Wu, Xipeng Wang.
Oncol Lett, 2017 Jan 27; 13(1). PMID: 28123537    Free PMC article.
Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade.
Nina Eissler, Yumeng Mao, +5 authors, Per Kogner.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123870    Free PMC article.
Modulation of macrophage antitumor potential by apoptotic lymphoma cells.
Jorine J L P Voss, Catriona A Ford, +7 authors, Christopher D Gregory.
Cell Death Differ, 2017 Feb 06; 24(6). PMID: 28157210    Free PMC article.
Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.
G Weitsman, N J Mitchell, +20 authors, T Ng.
Oncogene, 2017 Feb 07; 36(25). PMID: 28166195    Free PMC article.
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Michael F Cuccarese, J Matthew Dubach, +5 authors, Ralph Weissleder.
Nat Commun, 2017 Feb 09; 8. PMID: 28176769    Free PMC article.
Highly Cited.
The biology of uveal melanoma.
Adriana Amaro, Rosaria Gangemi, +4 authors, Ulrich Pfeffer.
Cancer Metastasis Rev, 2017 Feb 24; 36(1). PMID: 28229253    Free PMC article.
Tumor-associated macrophages: implications in cancer immunotherapy.
Amy J Petty, Yiping Yang.
Immunotherapy, 2017 Feb 25; 9(3). PMID: 28231720    Free PMC article.
Highly Cited. Review.
Modulators of the Balance between M1 and M2 Macrophages during Pregnancy.
Yong-Hong Zhang, Ming He, Yan Wang, Ai-Hua Liao.
Front Immunol, 2017 Feb 25; 8. PMID: 28232836    Free PMC article.
Highly Cited. Review.
The Dr. Jekyll and Mr. Hyde complexity of the macrophage response in disease.
Danielle Y F Twum, Lauren Burkard-Mandel, Scott I Abrams.
J Leukoc Biol, 2017 Mar 21; 102(2). PMID: 28319464    Free PMC article.
Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity.
Xenia Geeraerts, Evangelia Bolli, Sarah-Maria Fendt, Jo A Van Ginderachter.
Front Immunol, 2017 Apr 01; 8. PMID: 28360914    Free PMC article.
Highly Cited. Review.
Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells.
Peiming Zheng, Lei Chen, +5 authors, Lisong Shen.
J Exp Clin Cancer Res, 2017 Apr 15; 36(1). PMID: 28407783    Free PMC article.
Highly Cited.
Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature.
Xixi Zhao, Jingkun Qu, +8 authors, Shuqun Zhang.
Oncotarget, 2017 Apr 22; 8(18). PMID: 28427165    Free PMC article.
Highly Cited. Review.
Progress in tumor-associated macrophage (TAM)-targeted therapeutics.
Chayanon Ngambenjawong, Heather H Gustafson, Suzie H Pun.
Adv Drug Deliv Rev, 2017 Apr 30; 114. PMID: 28449873    Free PMC article.
Highly Cited. Review.
Programming and memory dynamics of innate leukocytes during tissue homeostasis and inflammation.
Christina Lee, Shuo Geng, +2 authors, Liwu Li.
J Leukoc Biol, 2017 May 10; 102(3). PMID: 28476750    Free PMC article.
NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.
Qiuji Wu, Awatef Allouch, +18 authors, Jean-Luc Perfettini.
Cell Death Differ, 2017 Jun 03; 24(9). PMID: 28574504    Free PMC article.
The peripheral monocyte count is associated with the density of tumor-associated macrophages in the tumor microenvironment of colorectal cancer: a retrospective study.
Masatsune Shibutani, Kiyoshi Maeda, +5 authors, Masaichi Ohira.
BMC Cancer, 2017 Jun 07; 17(1). PMID: 28583114    Free PMC article.
Intratumoral infection by CMV may change the tumor environment by directly interacting with tumor-associated macrophages to promote cancer immunity.
Dan A Erkes, Nicole A Wilski, Christopher M Snyder.
Hum Vaccin Immunother, 2017 Jun 13; 13(8). PMID: 28604162    Free PMC article.
Therapeutic effects of CSF1R-blocking antibodies in multiple myeloma.
Q Wang, Y Lu, +8 authors, Q Yi.
Leukemia, 2017 Jun 20; 32(1). PMID: 28626216    Free PMC article.
Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage-Mediated Lung Cancer in Mice.
Fei Xu, Wenqiang Cui, +9 authors, Jingcheng Dong.
Evid Based Complement Alternat Med, 2017 Jun 21; 2017. PMID: 28630636    Free PMC article.
Bioactivities of ethanol extract from the Antarctic freshwater microalga, Chloromonas sp.
Sung-Suk Suh, Eun Jin Yang, +4 authors, Sanghee Kim.
Int J Med Sci, 2017 Jun 24; 14(6). PMID: 28638272    Free PMC article.
Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models.
Cristina Belgiovine, Ezia Bello, +10 authors, Maurizio D'Incalci.
Br J Cancer, 2017 Jul 07; 117(5). PMID: 28683469    Free PMC article.
Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration.
Khalid Sossey-Alaoui, Elzbieta Pluskota, +6 authors, Edward F Plow.
Cancer Res, 2017 Jul 09; 77(18). PMID: 28687620    Free PMC article.
Chemotherapy and tumor microenvironment of pancreatic cancer.
Qiaofei Liu, Quan Liao, Yupei Zhao.
Cancer Cell Int, 2017 Jul 12; 17. PMID: 28694739    Free PMC article.
Liposomal prednisolone phosphate potentiates the antitumor activity of liposomal 5-fluorouracil in C26 murine colon carcinoma in vivo.
Laura Patras, Bianca Sylvester, +12 authors, Marcela Achim.
Cancer Biol Ther, 2017 Jul 12; 18(8). PMID: 28696813    Free PMC article.
AXL-associated tumor inflammation as a poor prognostic signature in chemotherapy-treated triple-negative breast cancer patients.
Giulia Bottai, Carlotta Raschioni, +16 authors, Libero Santarpia.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721387    Free PMC article.
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival.
Konrad Buscher, Erik Ehinger, +7 authors, Klaus Ley.
Nat Commun, 2017 Jul 25; 8. PMID: 28737175    Free PMC article.
Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies.
Géraldine Genard, Stéphane Lucas, Carine Michiels.
Front Immunol, 2017 Aug 05; 8. PMID: 28769933    Free PMC article.
Highly Cited. Review.
Antitumor Macrophage Response to Bacillus pumilus Ribonuclease (Binase).
Anna Makeeva, Julian Rodriguez-Montesinos, +4 authors, Olga N Ilinskaya.
Mediators Inflamm, 2017 Aug 15; 2017. PMID: 28804220    Free PMC article.
Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.
Dipongkor Saha, Robert L Martuza, Samuel D Rabkin.
Cancer Cell, 2017 Aug 16; 32(2). PMID: 28810147    Free PMC article.
Highly Cited.
Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer.
Minna Tervahartiala, Pekka Taimen, +4 authors, Peter J Boström.
Sci Rep, 2017 Oct 06; 7(1). PMID: 28978923    Free PMC article.
Targeting tumor-associated macrophages by anti-tumor Chinese materia medica.
Wei-Ling Pu, Li-Kang Sun, +7 authors, Margaret Gebauer.
Chin J Integr Med, 2017 Oct 11; 23(10). PMID: 28988387
IκB-kinase-ε in the tumor microenvironment is essential for the progression of gastric cancer.
Biao Geng, Chen Zhang, +12 authors, Qiang You.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088866    Free PMC article.
Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles.
Marta Machado-Pereira, Tiago Santos, +2 authors, Raquel Ferreira.
Mediators Inflamm, 2017 Nov 16; 2017. PMID: 29138531    Free PMC article.
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability.
Zhengjun Gao, Yiyuan Li, +13 authors, Jin Jin.
Nat Commun, 2017 Nov 29; 8(1). PMID: 29180626    Free PMC article.
Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.
Michael D Hadjidaniel, Sakunthala Muthugounder, +13 authors, Shahab Asgharzadeh.
Oncotarget, 2017 Dec 07; 8(53). PMID: 29207662    Free PMC article.
Tumor-associated macrophages and response to 5-fluorouracil adjuvant therapy in stage III colorectal cancer.
Alberto Malesci, Paolo Bianchi, +13 authors, Luigi Laghi.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209561    Free PMC article.
Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis.
Ward Celus, Giusy Di Conza, +4 authors, Massimiliano Mazzone.
Cell Rep, 2017 Dec 07; 21(10). PMID: 29212030    Free PMC article.
Immune microenvironment of experimental rat C6 gliomas resembles human glioblastomas.
Anna Gieryng, Dominika Pszczolkowska, +5 authors, Bozena Kaminska.
Sci Rep, 2017 Dec 16; 7(1). PMID: 29242629    Free PMC article.
Therapy for Cancer: Strategy of Combining Anti-Angiogenic and Target Therapies.
Valentina Comunanza, Federico Bussolino.
Front Cell Dev Biol, 2017 Dec 23; 5. PMID: 29270405    Free PMC article.
M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma.
Magdalena Jarosz-Biej, Natalia Kamińska, +7 authors, Stanisław Szala.
PLoS One, 2018 Jan 11; 13(1). PMID: 29320562    Free PMC article.
Highly Cited.
Contribution of Adipose Tissue to Development of Cancer.
Alyssa J Cozzo, Ashley M Fuller, Liza Makowski.
Compr Physiol, 2018 Jan 23; 8(1). PMID: 29357128    Free PMC article.
Highly Cited. Review.
Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment.
Grace Mahlbacher, Louis T Curtis, John Lowengrub, Hermann B Frieboes.
J Immunother Cancer, 2018 Feb 01; 6(1). PMID: 29382395    Free PMC article.
The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.
Irene Soncin, Jianpeng Sheng, +7 authors, Christiane Ruedl.
Nat Commun, 2018 Feb 10; 9(1). PMID: 29422500    Free PMC article.
Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners.
Paola Cappello, Claudia Curcio, +3 authors, Francesco Novelli.
Cancers (Basel), 2018 Feb 22; 10(2). PMID: 29462900    Free PMC article.
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype.
Degao Chen, Jing Xie, +14 authors, Bo Huang.
Nat Commun, 2018 Mar 02; 9(1). PMID: 29491374    Free PMC article.
Highly Cited.
Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.
Emanuele Giurisato, Qiuping Xu, +10 authors, Cathy Tournier.
Proc Natl Acad Sci U S A, 2018 Mar 07; 115(12). PMID: 29507229    Free PMC article.
Exploitation of Apoptotic Regulation in Cancer.
David S Ucker, Jerrold S Levine.
Front Immunol, 2018 Mar 15; 9. PMID: 29535707    Free PMC article.
The heterogenic tumor microenvironment of hepatocellular carcinoma and prognostic analysis based on tumor neo-vessels, macrophages and α-SMA.
Min Fang, Jingping Yuan, +6 authors, Ming Chen.
Oncol Lett, 2018 Mar 20; 15(4). PMID: 29552120    Free PMC article.
Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches.
Jelle J F Sleeboom, Hossein Eslami Amirabadi, +2 authors, Jaap M J den Toonder.
Dis Model Mech, 2018 Mar 21; 11(3). PMID: 29555848    Free PMC article.
Functional macrophages and gastrointestinal disorders.
Yue-Hong Liu, Yue Ding, +3 authors, Jing-Dong Xu.
World J Gastroenterol, 2018 Mar 24; 24(11). PMID: 29568199    Free PMC article.
Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
Mitra Modares Gilani, Zohreh Kazemi, +3 authors, Soureh Sheikham.
Asian Pac J Cancer Prev, 2018 Apr 26; 19(4). PMID: 29693335    Free PMC article.
Preclinical Development of a Bispecific Antibody that Safely and Effectively Targets CD19 and CD47 for the Treatment of B-Cell Lymphoma and Leukemia.
Vanessa Buatois, Zoë Johnson, +28 authors, Walter G Ferlin.
Mol Cancer Ther, 2018 May 11; 17(8). PMID: 29743205    Free PMC article.
Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis.
Lanfei Feng, Snezana Vujicic, +5 authors, Jerrold S Levine.
J Biol Chem, 2018 May 18; 293(26). PMID: 29769319    Free PMC article.
Myeloid-restricted ablation of Shp2 restrains melanoma growth by amplifying the reciprocal promotion of CXCL9 and IFN-γ production in tumor microenvironment.
P Xiao, Y Guo, +4 authors, Y Ke.
Oncogene, 2018 May 26; 37(37). PMID: 29795405
CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression.
Carlotta Raschioni, Giulia Bottai, +8 authors, Luca Di Tommaso.
Dis Markers, 2018 Jun 01; 2018. PMID: 29849822    Free PMC article.
Surface-Modified Macrophages Facilitate Tracking of Breast Cancer-Immune Interactions.
Bishnu P Joshi, Joseph Hardie, Michael A Mingroni, Michelle E Farkas.
ACS Chem Biol, 2018 Jun 02; 13(8). PMID: 29856604    Free PMC article.
Tumor-associated macrophages in human breast cancer produce new monocyte attracting and pro-angiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy.
Tengfei Liu, Irina Larionova, +13 authors, Julia Kzhyshkowska.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872578    Free PMC article.
Pharmacological inactivation of the PI3K p110δ prevents breast tumour progression by targeting cancer cells and macrophages.
Evangelia Goulielmaki, Miriam Bermudez-Brito, +6 authors, Evangelia A Papakonstanti.
Cell Death Dis, 2018 Jun 09; 9(6). PMID: 29880805    Free PMC article.
Transcriptional Regulation of Macrophages Polarization by MicroRNAs.
Heng Li, Ting Jiang, +2 authors, Guo-Jun Zhao.
Front Immunol, 2018 Jun 13; 9. PMID: 29892301    Free PMC article.
Highly Cited. Review.
Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples.
Kevin B Givechian, Kamil Wnuk, +5 authors, Patrick Soon-Shiong.
NPJ Genom Med, 2018 Jun 22; 3. PMID: 29928512    Free PMC article.
Preclinical evaluation of an innovative anti-TAM approach based on zoledronate-loaded erythrocytes.
Raffaella Sabatino, Serafina Battistelli, Mauro Magnani, Luigia Rossi.
Drug Deliv Transl Res, 2018 Jul 18; 8(5). PMID: 30014237
Assessment of CD52 expression in "double-hit" and "double-expressor" lymphomas: Implications for clinical trial eligibility.
Jeffrey W Craig, Michael J Mina, +4 authors, Olga Pozdnyakova.
PLoS One, 2018 Jul 19; 13(7). PMID: 30020951    Free PMC article.
Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors.
Yang Yang, Yu-Chen Ye, +5 authors, Hong-Yan Qin.
Cell Death Dis, 2018 Jul 20; 9(8). PMID: 30022048    Free PMC article.
Highly Cited.
Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice.
Jin-Tao Liu, Sheng-Xi Wu, Hua Zhang, Fang Kuang.
Neurotherapeutics, 2018 Aug 17; 15(4). PMID: 30112701    Free PMC article.
Macrophages of distinct origins contribute to tumor development in the lung.
Pierre-Louis Loyher, Pauline Hamon, +11 authors, Alexandre Boissonnas.
J Exp Med, 2018 Sep 12; 215(10). PMID: 30201786    Free PMC article.
Highly Cited.

;. PMID: 30345161
Highly Cited.
Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.
Hui-Ming Chen, William van der Touw, +16 authors, Shu-Hsia Chen.
J Clin Invest, 2018 Oct 24; 128(12). PMID: 30352428    Free PMC article.
Theoretical Studies on the Engagement of Interleukin 18 in the Immuno-Inflammatory Processes Underlying Atherosclerosis.
Dorota Formanowicz, Kaja Gutowska, Piotr Formanowicz.
Int J Mol Sci, 2018 Nov 08; 19(11). PMID: 30400655    Free PMC article.
From Friend to Enemy: Dissecting the Functional Alteration of Immunoregulatory Components during Pancreatic Tumorigenesis.
Hui-Ching Wang, Wen-Chun Hung, Li-Tzong Chen, Mei-Ren Pan.
Int J Mol Sci, 2018 Nov 16; 19(11). PMID: 30428588    Free PMC article.
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.
Anders Etzerodt, Kyriaki Tsalkitzi, +9 authors, Toby Lawrence.
J Exp Med, 2019 Aug 04; 216(10). PMID: 31375534    Free PMC article.
Highly Cited.
In vivo effects of mutant RHOA on tumor formation in an orthotopic inoculation model.
Takashi Nishizawa, Kiyotaka Nakano, +7 authors, Masami Suzuki.
Oncol Rep, 2019 Sep 06; 42(5). PMID: 31485674    Free PMC article.
Inhibition of EZH2 methyltransferase decreases immunoediting of mesothelioma cells by autologous macrophages through a PD-1-dependent mechanism.
Malik Hamaidia, Hélène Gazon, +4 authors, Luc Willems.
JCI Insight, 2019 Sep 20; 4(18). PMID: 31534051    Free PMC article.
Blockade of PD-L1 Enhances Cancer Immunotherapy by Regulating Dendritic Cell Maturation and Macrophage Polarization.
Nai-Yun Sun, Yu-Li Chen, +8 authors, Wen-Fang Cheng.
Cancers (Basel), 2019 Sep 25; 11(9). PMID: 31546897    Free PMC article.
Neuroendocrine Regulation of Tumor-Associated Immune Cells.
Claudia B Colon-Echevarria, Rocio Lamboy-Caraballo, Alexandra N Aquino-Acevedo, Guillermo N Armaiz-Pena.
Front Oncol, 2019 Nov 19; 9. PMID: 31737559    Free PMC article.
Beneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors.
Kerstin Kapp, Barbara Volz, +3 authors, Manuel Schmidt.
Oncoimmunology, 2019 Nov 20; 8(12). PMID: 31741757    Free PMC article.
Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth.
Meng Cao, Huaijiang Yan, +10 authors, Peng Cao.
J Immunother Cancer, 2019 Nov 30; 7(1). PMID: 31775862    Free PMC article.
Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment.
Yoshiro Itatani, Kenji Kawada, Yoshiharu Sakai.
Int J Mol Sci, 2019 Nov 24; 20(23). PMID: 31756952    Free PMC article.
Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages In vitro and In vivo.
Hongbin Wang, Binghong Chen, +2 authors, Xiaobo Li.
Int J Biol Sci, 2020 Jan 02; 16(1). PMID: 31892854    Free PMC article.
YKL-39 as a Potential New Target for Anti-Angiogenic Therapy in Cancer.
Julia Kzhyshkowska, Irina Larionova, Tengfei Liu.
Front Immunol, 2020 Feb 11; 10. PMID: 32038607    Free PMC article.
Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice.
Sharmilla Devi Jayasingam, Marimuthu Citartan, +3 authors, Ewe Seng Ch'ng.
Front Oncol, 2020 Feb 11; 9. PMID: 32039007    Free PMC article.
Differences of the immune cell landscape between normal and tumor tissue in human prostate.
E Zhang, F Dai, +4 authors, Y Qiao.
Clin Transl Oncol, 2019 May 12; 22(3). PMID: 31077088
Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses.
Clément Anfray, Aldo Ummarino, Fernando Torres Andón, Paola Allavena.
Cells, 2019 Dec 28; 9(1). PMID: 31878087    Free PMC article.
Ferroptosis in Cancer Cell Biology.
Christina M Bebber, Fabienne Müller, +2 authors, Silvia von Karstedt.
Cancers (Basel), 2020 Jan 16; 12(1). PMID: 31936571    Free PMC article.
Distinct Role of CD11b+Ly6G-Ly6C- Myeloid-Derived Cells on the Progression of the Primary Tumor and Therapy-Associated Recurrent Brain Tumor.
Sheng-Yan Wu, Chi-Shiun Chiang.
Cells, 2019 Dec 28; 9(1). PMID: 31878276    Free PMC article.
CD68, CD163, and matrix metalloproteinase 9 (MMP-9) co-localization in breast tumor microenvironment predicts survival differently in ER-positive and -negative cancers.
Vasiliki Pelekanou, Franz Villarroel-Espindola, +2 authors, David L Rimm.
Breast Cancer Res, 2018 Dec 19; 20(1). PMID: 30558648    Free PMC article.
Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages.
Sean P Arlauckas, Seth B Garren, +4 authors, Ralph Weissleder.
Theranostics, 2019 Jan 08; 8(21). PMID: 30613266    Free PMC article.
Highly Cited.
Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I : C) promote melanoma regression.
Jiaojiao Zhao, Zhengkui Zhang, +5 authors, Yayi Hou.
Theranostics, 2019 Jan 08; 8(22). PMID: 30613299    Free PMC article.
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Tumor Microenvironment Modulates Immunological Outcomes of Myeloid Cells with mTORC1 Disruption.
Chuanlin Ding, Xiaomin Sun, +3 authors, Jun Yan.
J Immunol, 2019 Jan 23; 202(5). PMID: 30665937    Free PMC article.
Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity.
Kun He, Shengguo Jia, +2 authors, Lisa X Xu.
Cell Death Dis, 2019 Mar 06; 10(3). PMID: 30833570    Free PMC article.
Immune targets in the tumor microenvironment treated by radiotherapy.
Omer M Ozpiskin, Lu Zhang, Jian Jian Li.
Theranostics, 2019 Mar 15; 9(5). PMID: 30867826    Free PMC article.
Highly Cited. Review.
Harnessing the innate immune system and local immunological microenvironment to treat colorectal cancer.
Jakob Nikolas Kather, Niels Halama.
Br J Cancer, 2019 Apr 03; 120(9). PMID: 30936499    Free PMC article.
Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity.
Javier Mora, Christina Mertens, +3 authors, Michaela Jung.
Cells, 2019 May 15; 8(5). PMID: 31083487    Free PMC article.
Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib.
Yang Yang, Mayu Sun, +10 authors, Hui Wang.
J Immunother Cancer, 2020 Mar 18; 8(1). PMID: 32179631    Free PMC article.
Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies.
Yun Liu, Jianfeng Guo, Leaf Huang.
Theranostics, 2020 Mar 21; 10(7). PMID: 32194857    Free PMC article.
Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype.
David Eisel, Krishna Das, +3 authors, Stefan B Eichmüller.
Front Immunol, 2019 Mar 12; 10. PMID: 30853959    Free PMC article.
Contribution of Macrophages and T Cells in Skeletal Metastasis.
Veronica Mendoza-Reinoso, Laurie K McCauley, Pierrick G J Fournier.
Cancers (Basel), 2020 Apr 25; 12(4). PMID: 32326073    Free PMC article.
The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ.
Yeo Song Lee, Su Jeong Song, +3 authors, Yong Beom Cho.
Exp Mol Med, 2020 May 24; 52(5). PMID: 32444799    Free PMC article.
The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer.
Marek Nowak, Magdalena Klink.
Cells, 2020 May 28; 9(5). PMID: 32456078    Free PMC article.
Purification and Characterization of a New CRISP-Related Protein from Scapharca broughtonii and Its Immunomodulatory Activity.
Wanying Liu, Sixue Bi, +7 authors, Rongmin Yu.
Mar Drugs, 2020 Jun 10; 18(6). PMID: 32512803    Free PMC article.
M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.
Eva M Garrido-Martin, Toby W P Mellows, +13 authors, Tilman Sanchez-Elsner.
J Immunother Cancer, 2020 Jul 24; 8(2). PMID: 32699181    Free PMC article.
The expanding landscape of inflammatory cells affecting cancer therapy.
Ralph Weissleder, Mikael J Pittet.
Nat Biomed Eng, 2020 Mar 24; 4(5). PMID: 32203281    Free PMC article.
Interactions between Cisplatin and Quercetin at Physiological and Hyperthermic Conditions on Cancer Cells In Vitro and In Vivo.
Nada Oršolić, Dyana Odeh, +2 authors, Darko Kučan.
Molecules, 2020 Jul 28; 25(14). PMID: 32709143    Free PMC article.
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Si Mi, Yan Qu, +3 authors, Yufeng Cheng.
Onco Targets Ther, 2020 Aug 18; 13. PMID: 32801779    Free PMC article.
Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer.
Victoria Stary, Brigitte Wolf, +8 authors, Michael Bergmann.
J Immunother Cancer, 2020 Aug 21; 8(2). PMID: 32817359    Free PMC article.
Tumor-associated macrophages: Role in the pathological process of tumorigenesis and prospective therapeutic use (Review).
Olga V Zhukova, Tatiana F Kovaleva, +2 authors, Irina V Mukhina.
Biomed Rep, 2020 Sep 17; 13(5). PMID: 32934819    Free PMC article.
Study on metastasis inhibition of Kejinyan decoction on lung cancer by affecting tumor microenvironment.
Meijuan Chen, Cheng Hu, +8 authors, Xu Zhang.
Cancer Cell Int, 2020 Sep 19; 20. PMID: 32943999    Free PMC article.
Aromatic secondary amine-functionalized fluorescent NO probes: improved detection sensitivity for NO and potential applications in cancer immunotherapy studies.
Yingying Huo, Junfeng Miao, +3 authors, Wei Guo.
Chem Sci, 2019 Feb 05; 10(1). PMID: 30713625    Free PMC article.
Macrophages in Colorectal Cancer Liver Metastases.
Nina Cortese, Cristiana Soldani, +4 authors, Matteo Donadon.
Cancers (Basel), 2019 May 10; 11(5). PMID: 31067629    Free PMC article.
Interaction of tumor-associated macrophages and cancer chemotherapy.
Irina Larionova, Nadezhda Cherdyntseva, +3 authors, Julia Kzhyshkowska.
Oncoimmunology, 2019 May 31; 8(7). PMID: 31143517    Free PMC article.
Highly Cited. Review.
G protein-coupled receptor kinase 2 regulating β2-adrenergic receptor signaling in M2-polarized macrophages contributes to hepatocellular carcinoma progression.
Jing-Jing Wu, Yang Yang, +3 authors, Wei Wei.
Onco Targets Ther, 2019 Aug 03; 12. PMID: 31371988    Free PMC article.
Tumor-associated macrophages affect the biological behavior of lung adenocarcinoma A549 cells through the PI3K/AKT signaling pathway.
Shiyang Yuan, Yaling Dong, +4 authors, Junping Xie.
Oncol Lett, 2019 Aug 20; 18(2). PMID: 31423252    Free PMC article.
Association between circulating tumor cells and peripheral blood monocytes in metastatic breast cancer.
Ugo De Giorgi, Michal Mego, +7 authors, James M Reuben.
Ther Adv Med Oncol, 2019 Aug 28; 11. PMID: 31452692    Free PMC article.
Significance of monocyte counts on tumor characteristics and survival outcome of women with endometrial cancer.
Koji Matsuo, Marianne S Hom, +4 authors, Anil K Sood.
Gynecol Oncol, 2015 May 28; 138(2). PMID: 26013698    Free PMC article.
Mechanism of Sanguinarine in Inhibiting Macrophages to Promote Metastasis and Proliferation of Lung Cancer via Modulating the Exosomes in A549 Cells.
Yuanyuan Yu, Yingbin Luo, +7 authors, Yan Li.
Onco Targets Ther, 2020 Sep 29; 13. PMID: 32982290    Free PMC article.
Doxorubicin modulated clock genes and cytokines in macrophages extracted from tumor-bearing mice.
Alexandre Abilio S Teixeira, Luana Amorim Biondo, +6 authors, José Cesar Rosa Neto.
Cancer Biol Ther, 2020 Jan 15; 21(4). PMID: 31931676    Free PMC article.
Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling.
Jiaquan Yu, Erwin Berthier, +7 authors, Ashleigh B Theberge.
Nat Biomed Eng, 2019 Aug 21; 3(10). PMID: 31427781    Free PMC article.
M1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer.
Masanori Oshi, Yoshihisa Tokumaru, +9 authors, Kazuaki Takabe.
Sci Rep, 2020 Oct 08; 10(1). PMID: 33024179    Free PMC article.
SLC2A3 promotes macrophage infiltration by glycolysis reprogramming in gastric cancer.
Xingxing Yao, Zhanke He, +4 authors, Jiaolong Shi.
Cancer Cell Int, 2020 Oct 17; 20. PMID: 33061855    Free PMC article.
Immunogenic Cell Death and Elimination of Immunosuppressive Cells: A Double-Edged Sword of Chemotherapy.
Jean-David Fumet, Emeric Limagne, Marion Thibaudin, Francois Ghiringhelli.
Cancers (Basel), 2020 Sep 20; 12(9). PMID: 32947882    Free PMC article.
Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil®) in C26 Tumor-Bearing Immunocompetent Mice.
Takuma Takayama, Taro Shimizu, +4 authors, Tatsuhiro Ishida.
Pharmaceutics, 2020 Oct 23; 12(10). PMID: 33086690    Free PMC article.
Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages.
Seung Hyeon Kim, Soma Saeidi, +10 authors, Young-Joon Surh.
Neoplasia, 2020 Oct 12; 22(11). PMID: 33039895    Free PMC article.
Targeting Tumor-Associated Macrophages in Anti-Cancer Therapies: Convincing the Traitors to Do the Right Thing.
Cristina Belgiovine, Elisabeth Digifico, +2 authors, Fernando Torres Andón.
J Clin Med, 2020 Oct 15; 9(10). PMID: 33050070    Free PMC article.
Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells.
Qing Zhang, Junwen Zhang, +3 authors, Fusheng Liu.
Cell Biosci, 2020 Nov 03; 10. PMID: 33133514    Free PMC article.
Long noncoding RNA: a dazzling dancer in tumor immune microenvironment.
Yalu Zhang, Qiaofei Liu, Quan Liao.
J Exp Clin Cancer Res, 2020 Nov 06; 39(1). PMID: 33148302    Free PMC article.
Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis.
Matteo Donadon, Guido Torzilli, +16 authors, Federica Marchesi.
J Exp Med, 2020 Aug 14; 217(11). PMID: 32785653    Free PMC article.
In pancreatic cancer, chemotherapy increases antitumor responses to tumor-associated antigens and potentiates DNA vaccination.
Giorgia Mandili, Claudia Curcio, +12 authors, Francesco Novelli.
J Immunother Cancer, 2020 Oct 30; 8(2). PMID: 33115943    Free PMC article.
Sexual Dimorphism in Innate Immunity.
Sébastien Jaillon, Kevin Berthenet, Cecilia Garlanda.
Clin Rev Allergy Immunol, 2017 Oct 01; 56(3). PMID: 28963611
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Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.
Eric M Mastria, Leon Y Cai, +7 authors, Ashutosh Chilkoti.
J Control Release, 2017 Nov 18; 269. PMID: 29146246    Free PMC article.
The predictive value and the correlation of peripheral absolute monocyte count, tumor-associated macrophage and microvessel density in patients with colon cancer.
Zhigui Li, Zhaofen Xu, +4 authors, Xiaoting Wu.
Medicine (Baltimore), 2018 May 26; 97(21). PMID: 29794753    Free PMC article.
Adjuvant Thalidomide and Metronomic Chemotherapy for the Treatment of Canine Malignant Mammary Gland Neoplasms.
Cecilia Bonolo DE Campos, Gleidice Eunice Lavalle, +4 authors, Geovanni Dantas Cassali.
In Vivo, 2018 Oct 24; 32(6). PMID: 30348731    Free PMC article.
Reprogramming Tumor Associated Macrophage Phenotype by a Polysaccharide from Ilex asprella for Sarcoma Immunotherapy.
Qiu Li, Zhihui Hao, +2 authors, Wenwen Zhao.
Int J Mol Sci, 2018 Dec 06; 19(12). PMID: 30513582    Free PMC article.
Tumor-associated macrophages: a short compendium.
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Cell Mol Life Sci, 2019 Feb 13; 76(8). PMID: 30747250
Metformin enhances gefitinib efficacy by interfering with interactions between tumor-associated macrophages and head and neck squamous cell carcinoma cells.
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Cell Oncol (Dordr), 2019 Apr 20; 42(4). PMID: 31001733
IFI30 expression is an independent unfavourable prognostic factor in glioma.
Xiu Liu, Chunyan Song, +3 authors, Wenbin Li.
J Cell Mol Med, 2020 Sep 25; 24(21). PMID: 32969157    Free PMC article.
Natural Phenolic Acid, Product of the Honey Bee, for the Control of Oxidative Stress, Peritoneal Angiogenesis, and Tumor Growth in Mice.
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Molecules, 2020 Dec 03; 25(23). PMID: 33261130    Free PMC article.
Incorporating Tumor-Associated Macrophages into Engineered Models of Glioma.
Erin A Akins, Manish K Aghi, Sanjay Kumar.
iScience, 2020 Dec 10; 23(12). PMID: 33294780    Free PMC article.
Hypoxia Correlates With Poor Survival and M2 Macrophage Infiltration in Colorectal Cancer.
Lina Qi, Jiani Chen, Yanmei Yang, Wangxiong Hu.
Front Oncol, 2020 Dec 18; 10. PMID: 33330037    Free PMC article.
Organotypic Modeling of the Tumor Landscape.
Maria M Haykal, Clara Nahmias, Christine Varon, Océane C B Martin.
Front Cell Dev Biol, 2020 Dec 18; 8. PMID: 33330508    Free PMC article.
The Acute Effects of 5 Fluorouracil on Skeletal Muscle Resident and Infiltrating Immune Cells in Mice.
Brandon N VanderVeen, Alexander T Sougiannis, +3 authors, E Angela Murphy.
Front Physiol, 2020 Dec 29; 11. PMID: 33364975    Free PMC article.
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages.
Degao Chen, Xiaomei Zhang, Zhongjun Li, Bo Zhu.
Theranostics, 2021 Jan 05; 11(3). PMID: 33391518    Free PMC article.
Tumor microenvironment promotes breast cancer chemoresistance.
Umar Mehraj, Abid Hamid Dar, Nissar A Wani, Manzoor A Mir.
Cancer Chemother Pharmacol, 2021 Jan 10; 87(2). PMID: 33420940
A conserved dendritic-cell regulatory program limits antitumour immunity.
Barbara Maier, Andrew M Leader, +20 authors, Miriam Merad.
Nature, 2020 Apr 10; 580(7802). PMID: 32269339    Free PMC article.
Modulation of Macrophages M1/M2 Polarization Using Carbohydrate-Functionalized Polymeric Nanoparticles.
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Polymers (Basel), 2021 Jan 01; 13(1). PMID: 33379389    Free PMC article.
Tumor-associated myeloid cells: diversity and therapeutic targeting.
Alberto Mantovani, Federica Marchesi, +2 authors, Paola Allavena.
Cell Mol Immunol, 2021 Jan 22; 18(3). PMID: 33473192    Free PMC article.
Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti-tumor immunity.
Laura M Sipe, Mehdi Chaib, +2 authors, Liza Makowski.
Immunol Rev, 2020 Apr 23; 295(1). PMID: 32320071    Free PMC article.
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
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Nat Biomed Eng, 2019 Apr 25; 2(8). PMID: 31015631    Free PMC article.
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Multifaceted activities of transcription factor EB in cancer onset and progression.
Elena Astanina, Federico Bussolino, Gabriella Doronzo.
Mol Oncol, 2020 Dec 01; 15(2). PMID: 33252196    Free PMC article.
ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway.
Dafeng Xu, Yu Wang, +9 authors, Jinfang Zheng.
Cell Death Dis, 2021 Feb 10; 12(2). PMID: 33558466    Free PMC article.
Multicellular 3D Models to Study Tumour-Stroma Interactions.
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Int J Mol Sci, 2021 Feb 11; 22(4). PMID: 33562840    Free PMC article.
The cancer cell secretome drives cooperative manipulation of the tumour microenvironment to accelerate tumourigenesis.
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Fac Rev, 2021 Mar 05; 10. PMID: 33659922    Free PMC article.
The clinical implication of soluble PD-L1 (sPD-L1) in patients with breast cancer and its biological function in regulating the function of T lymphocyte.
Baojuan Han, Lina Dong, +8 authors, Qingyuan Zhang.
Cancer Immunol Immunother, 2021 Mar 11; 70(10). PMID: 33688997    Free PMC article.
Lipid Metabolism in Tumor-Associated Macrophages.
Yuancai Xiang, Hongming Miao.
Adv Exp Med Biol, 2021 Mar 20; 1316. PMID: 33740245
Influence of tumor-infiltrating immune cells on local control rate, distant metastasis, and survival in patients with soft tissue sarcoma.
Maria A Smolle, Laurin Herbsthofer, +16 authors, Joanna Szkandera.
Oncoimmunology, 2021 Mar 26; 10(1). PMID: 33763294    Free PMC article.
Macrophages and microglia: the cerberus of glioblastoma.
Alice Buonfiglioli, Dolores Hambardzumyan.
Acta Neuropathol Commun, 2021 Mar 27; 9(1). PMID: 33766119    Free PMC article.
Tumor Microenvironment in Metastatic Colorectal Cancer: The Arbitrator in Patients' Outcome.
Cristina Galindo-Pumariño, Manuel Collado, Mercedes Herrera, Cristina Peña.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33800796    Free PMC article.
Tumor-Associated Macrophages and Inflammatory Microenvironment in Gastric Cancer: Novel Translational Implications.
Karim Rihawi, Angela Dalia Ricci, +6 authors, Matteo Renzulli.
Int J Mol Sci, 2021 May 01; 22(8). PMID: 33916915    Free PMC article.
In Situ Vaccination as a Strategy to Modulate the Immune Microenvironment of Hepatocellular Carcinoma.
Isabella Lurje, Wiebke Werner, +3 authors, Linda Hammerich.
Front Immunol, 2021 May 25; 12. PMID: 34025657    Free PMC article.
Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells.
Yang Tang, Maoyan Jiang, +7 authors, Xixian Ke.
Mol Med Rep, 2021 Jun 04; 24(2). PMID: 34080032    Free PMC article.
Data Driven Mathematical Model of FOLFIRI Treatment for Colon Cancer.
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Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34071939    Free PMC article.
Iron Released after Cryo-Thermal Therapy Induced M1 Macrophage Polarization, Promoting the Differentiation of CD4+ T Cells into CTLs.
Shicheng Wang, Man Cheng, +3 authors, Ping Liu.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34209797    Free PMC article.
Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes.
Katerina E Miari, Monica L Guzman, Helen Wheadon, Mark T S Williams.
Front Cell Dev Biol, 2021 Jul 13; 9. PMID: 34249942    Free PMC article.
Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment.
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Int J Mol Sci, 2021 Jul 21; 22(13). PMID: 34281293    Free PMC article.
HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.
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Cancer Med, 2021 Jun 22; 10(15). PMID: 34152094    Free PMC article.
Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC-1 tumor-bearing mice with PD-1 blockade by modulating macrophage heterogeneity and the activation of CD8+ T cells in the tumor microenvironment.
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Clin Transl Immunology, 2021 Aug 26; 10(8). PMID: 34429969    Free PMC article.
Poor Prognosis and Therapeutic Responses in LILRB1-Expressing M2 Macrophages-Enriched Gastric Cancer Patients.
Yawei Zhang, Han Wang, +5 authors, Yulong He.
Front Oncol, 2021 Sep 07; 11. PMID: 34485116    Free PMC article.
Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression.
Elena Magrini, Sabrina Di Marco, +17 authors, Cecilia Garlanda.
Nat Cancer, 2021 Sep 11; 2(2). PMID: 34505065    Free PMC article.
Cancer derived exosomes induce macrophages immunosuppressive polarization to promote bladder cancer progression.
Ziming Jiang, Yiming Zhang, +3 authors, Jinjian Yang.
Cell Commun Signal, 2021 Sep 16; 19(1). PMID: 34521440    Free PMC article.
Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor Microenvironment.
Zicong He, Shuixing Zhang.
Front Immunol, 2021 Oct 05; 12. PMID: 34603327    Free PMC article.
Multifunctional silica nanocomposites prime tumoricidal immunity for efficient cancer immunotherapy.
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J Nanobiotechnology, 2021 Oct 20; 19(1). PMID: 34663354    Free PMC article.
Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment.
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Int J Mol Sci, 2021 Oct 24; 22(20). PMID: 34681881    Free PMC article.
Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism.
Lina Abdelghany, Xu Zhang, +4 authors, Tao-Sheng Li.
Med Oncol, 2021 Nov 12; 39(1). PMID: 34761342
Melanoma Immunotherapy and Precision Medicine in the Era of Tumor Micro-Tissue Engineering: Where Are We Now and Where Are We Going?
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Cancers (Basel), 2021 Nov 28; 13(22). PMID: 34830940    Free PMC article.
Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer.
Hyeong Chan Shin, Incheol Seo, +5 authors, Hye Won Lee.
Life (Basel), 2021 Nov 28; 11(11). PMID: 34833118    Free PMC article.
Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.
Olga Trofimova, Ksenija Korotkaja, +4 authors, Anna Zajakina.
Vaccines (Basel), 2021 Nov 28; 9(11). PMID: 34835178    Free PMC article.
Advances in molecular mechanisms of interaction between Mycobacterium tuberculosis and lung cancer: a narrative review.
Kunlong Xiong, Wenwen Sun, Yayi He, Lin Fan.
Transl Lung Cancer Res, 2021 Dec 04; 10(10). PMID: 34858788    Free PMC article.
Carbon Monoxide Regulates Macrophage Differentiation and Polarization toward the M2 Phenotype through Upregulation of Heme Oxygenase 1.
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Cells, 2021 Dec 25; 10(12). PMID: 34943953    Free PMC article.
Interaction of Glia Cells with Glioblastoma and Melanoma Cells under the Influence of Phytocannabinoids.
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Cells, 2022 Jan 12; 11(1). PMID: 35011711    Free PMC article.
Neurofibromin and suppression of tumorigenesis: beyond the GAP.
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Inflammation and Myeloid Cells in Cancer Progression and Metastasis.
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Front Cell Dev Biol, 2022 Feb 08; 9. PMID: 35127700    Free PMC article.
Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway.
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J Exp Clin Cancer Res, 2022 Feb 13; 41(1). PMID: 35148799    Free PMC article.
Tumor-Associated Macrophages: Reasons to Be Cheerful, Reasons to Be Fearful.
Izabela Szulc-Kielbik, Michal Kielbik.
Exp Suppl, 2022 Feb 16; 113. PMID: 35165862
Tumor-Associated Macrophages: Key Players in Triple-Negative Breast Cancer.
Xia Qiu, Tianjiao Zhao, +2 authors, Zhaoming Li.
Front Oncol, 2022 Mar 04; 12. PMID: 35237507    Free PMC article.
TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization.
Lifang Zhao, Hongyan Zhang, +4 authors, Handong Jiang.
Acta Pharm Sin B, 2022 Mar 09; 12(2). PMID: 35256947    Free PMC article.
Qi Ling decreases paclitaxel resistance in the human prostate cancer by reversing tumor-associated macrophages function.
Hongwen Cao, Dan Wang, +2 authors, Lei Chen.
Aging (Albany NY), 2022 Feb 24; 14(4). PMID: 35193986    Free PMC article.
Establishing a Macrophage Phenotypic Switch-Associated Signature-Based Risk Model for Predicting the Prognoses of Lung Adenocarcinoma.
Jun Chen, Chao Zhou, Ying Liu.
Front Oncol, 2022 Mar 15; 11. PMID: 35284334    Free PMC article.
Mitochondrial DNA on Tumor-Associated Macrophages Polarization and Immunity.
Yaxin Guo, Hsiang-I Tsai, Lirong Zhang, Haitao Zhu.
Cancers (Basel), 2022 Mar 26; 14(6). PMID: 35326602    Free PMC article.
UEG Week 2020 Poster Presentations.
United European Gastroenterol J, 2020 Oct 13; 8(8_suppl). PMID: 33043826    Free PMC article.
OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.
Shuai Yang, Jiangang Zhang, +10 authors, Yongsheng Li.
Cancer Immunol Immunother, 2022 Mar 31;. PMID: 35353239
Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy.
Xiaoxue Xie, Yi Feng, +13 authors, Hong Yang.
Bioact Mater, 2022 Apr 08; 16. PMID: 35386322    Free PMC article.
The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma.
Kaiting Wang, Xinyao Qiu, +2 authors, Lei Chen.
Cancer Biol Med, 2021 Oct 01;. PMID: 34591416    Free PMC article.
Reprogramming the tumor microenvironment by genome editing for precision cancer therapy.
Ke Liu, Jia-Jia Cui, +5 authors, Ji-Ye Yin.
Mol Cancer, 2022 Apr 13; 21(1). PMID: 35410257    Free PMC article.
Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle-invasive bladder cancer.
Yijia Xu, Han Zeng, +6 authors, Jiejie Xu.
J Immunother Cancer, 2022 Mar 27; 10(3). PMID: 35338085    Free PMC article.
The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies.
Victoria C Brom, Christof Burger, Dieter C Wirtz, Frank A Schildberg.
Front Immunol, 2022 Apr 15; 13. PMID: 35418973    Free PMC article.
Innate Immunity and Cancer Pathophysiology.
Laura Maiorino, Juliane Daßler-Plenker, Lijuan Sun, Mikala Egeblad.
Annu Rev Pathol, 2021 Nov 18; 17. PMID: 34788549    Free PMC article.
The pro-tumorigenic host response to cancer therapies.
Yuval Shaked.
Nat Rev Cancer, 2019 Oct 28; 19(12). PMID: 31645711
Roles and new Insights of Macrophages in the Tumor Microenvironment of Thyroid Cancer.
Qi Liu, Wei Sun, Hao Zhang.
Front Pharmacol, 2022 Apr 29; 13. PMID: 35479325    Free PMC article.
The role of tumor-associated macrophages in solid malignancies - an overview of current knowledge.
Jozef Muri, Jaroslava Chylikova, +2 authors, Vojtech Kamarad.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2021 Dec 18; 166(2). PMID: 34916674