Journal Article
. 2015 Apr;22(Suppl 1).
doi: 10.3747/co.22.2320.

Optimal systemic therapy for early breast cancer in women: a clinical practice guideline

A Eisen 1 G G Fletcher 2 S Gandhi 1 M Mates 3 O C Freedman 4 S F Dent 5 M E Trudeau 1 members of the Early Breast Cancer Systemic Therapy Consensus Panel  
Affiliations
  • PMID: 25848340
  •     65 References
  •     16 citations

Abstract

The Breast Cancer Disease Site Group of Cancer Care Ontario identified the need for new guidelines for the adjuvant systemic therapy of early-stage breast cancer. The specific question to be addressed was "What is the optimal adjuvant systemic therapy for female patients with early-stage operable breast cancer, when patient and disease factors are considered?" A systematic review was prepared based on literature searches conducted using the medline and embase databases for the period January 2008 to March 5, 2012, and updated to May 12, 2014. Guidelines were located from that search, from the Standards and Guidelines Evidence directory of cancer guidelines, and from the Web sites of major guideline organizations. The literature located was subdivided into the broad categories of chemotherapy, hormonal therapy, and therapy targeted to her2 (human epidermal growth factor receptor 2). Although several of the systemic therapies discussed in this guideline can be considered in the neoadjuvant setting, the review focused on trials with rates of disease-free and overall survival as endpoints and thus excluded several trials that used pathologic complete response as a primary endpoint. Based on the systematic review, the working group drafted recommendations on the use of chemotherapy, hormonal therapy, and targeted therapy; based on their professional experience, they also drafted recommendations on patient and disease characteristics and recurrence risk. The literature review and draft recommendations were circulated to a consensus panel of medical oncologists who had expertise in breast cancer and who represented the regions of Ontario. Items without initial consensus were discussed at an in-person consensus meeting held in Toronto, November 23, 2012. The final recommendations are those for which consensus was reached before or at the meeting. Some of the key evidence was revised after the updated literature search. Evidence reviews for systemic chemotherapy, endocrine therapy, and targeted therapy for her2-positive disease are reported in separate articles in this supplement. The full three-part 1-21 evidence-based series, including complete details of the development and consensus processes, can be found on the Cancer Care Ontario Web site at https://www.cancercare.on.ca/toolbox/qualityguidelines/diseasesite/breast-ebs.

Keywords: Treatment guidelines; adjuvant systemic treatment; chemotherapy; consensus process; early breast cancer; endocrine therapy; her2-targeted therapy.

Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen.
Mitch Dowsett, Jack Cuzick, +16 authors, Richard Peto.
J Clin Oncol, 2009 Dec 02; 28(3). PMID: 19949017
Highly Cited.
Risk of menopause during the first year after breast cancer diagnosis.
P J Goodwin, M Ennis, +2 authors, N Hood.
J Clin Oncol, 1999 Nov 24; 17(8). PMID: 10561298
Adjuvant aromatase inhibitors for early breast cancer after chemotherapy-induced amenorrhoea: caution and suggested guidelines.
Ian E Smith, Mitch Dowsett, +4 authors, Daniel Hayes.
J Clin Oncol, 2006 Jun 01; 24(16). PMID: 16735701
6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomised phase 3 trial.
Xavier Pivot, Gilles Romieu, +18 authors, PHARE trial investigators.
Lancet Oncol, 2013 Jun 15; 14(8). PMID: 23764181
Highly Cited.
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), R Peto, +15 authors, K Pritchard.
Lancet, 2011 Dec 14; 379(9814). PMID: 22152853    Free PMC article.
Highly Cited.
HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial.
Edith A Perez, Monica M Reinholz, +14 authors, Robert B Jenkins.
J Clin Oncol, 2010 Aug 11; 28(28). PMID: 20697084    Free PMC article.
Longer-term assessment of trastuzumab-related cardiac adverse events in the Herceptin Adjuvant (HERA) trial.
Marion Procter, Thomas M Suter, +17 authors, Martine J Piccart-Gebhart.
J Clin Oncol, 2010 Jun 10; 28(21). PMID: 20530280
Clinical significance and management of sentinel node micrometastasis in invasive breast cancer.
Sadaf Jafferbhoy, Billy McWilliams.
Clin Breast Cancer, 2012 Oct 09; 12(5). PMID: 23039999
Review.
Adjuvant trastuzumab in HER2-positive breast cancer.
Dennis Slamon, Wolfgang Eiermann, +21 authors, Breast Cancer International Research Group.
N Engl J Med, 2011 Oct 14; 365(14). PMID: 21991949    Free PMC article.
Highly Cited.
St. Gallen 2011: Summary of the Consensus Discussion.
Michael Gnant, Nadia Harbeck, Christoph Thomssen.
Breast Care (Basel), 2011 Jun 03; 6(2). PMID: 21633630    Free PMC article.
Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
Viviana Galimberti, Bernard F Cole, +25 authors, International Breast Cancer Study Group Trial 23-01 investigators.
Lancet Oncol, 2013 Mar 16; 14(4). PMID: 23491275    Free PMC article.
Highly Cited.
Adjuvant capecitabine, docetaxel, cyclophosphamide, and epirubicin for early breast cancer: final analysis of the randomized FinXX trial.
Heikki Joensuu, Pirkko-Liisa Kellokumpu-Lehtinen, +17 authors, Henrik Lindman.
J Clin Oncol, 2011 Nov 23; 30(1). PMID: 22105826
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), C Davies, +11 authors, R Peto.
Lancet, 2011 Aug 02; 378(9793). PMID: 21802721    Free PMC article.
Highly Cited.
Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.
Antonio C Wolff, M Elizabeth H Hammond, +19 authors, College of American Pathologists.
Arch Pathol Lab Med, 2013 Oct 09; 138(2). PMID: 24099077    Free PMC article.
Highly Cited.
Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study.
Mitch Dowsett, Jack Cuzick, +11 authors, Steven Shak.
J Clin Oncol, 2010 Mar 10; 28(11). PMID: 20212256
Highly Cited.
An investigation into the performance of the Adjuvant! Online prognostic programme in early breast cancer for a cohort of patients in the United Kingdom.
H E Campbell, M A Taylor, A L Harris, A M Gray.
Br J Cancer, 2009 Sep 03; 101(7). PMID: 19724274    Free PMC article.
Adjuvant docetaxel for node-positive breast cancer.
Miguel Martin, Tadeusz Pienkowski, +30 authors, Breast Cancer International Research Group 001 Investigators.
N Engl J Med, 2005 Jun 03; 352(22). PMID: 15930421
Highly Cited.
Very high quantitative tumor HER2 content and outcome in early breast cancer.
H Joensuu, J Sperinde, +12 authors, M Bates.
Ann Oncol, 2011 Feb 03; 22(9). PMID: 21285132
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer.
Edward H Romond, Edith A Perez, +22 authors, Norman Wolmark.
N Engl J Med, 2005 Oct 21; 353(16). PMID: 16236738
Highly Cited.
Delayed adjuvant tamoxifen: ten-year results of a collaborative randomized controlled trial in early breast cancer (TAM-02 trial)
T Delozier, O Switsers, +9 authors, J Macé-Lesech.
Ann Oncol, 2000 Jul 25; 11(5). PMID: 10907942
Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011.
A Goldhirsch, W C Wood, +4 authors, Panel members.
Ann Oncol, 2011 Jun 29; 22(8). PMID: 21709140    Free PMC article.
Highly Cited.
Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31.
Edith A Perez, Edward H Romond, +7 authors, Norman Wolmark.
J Clin Oncol, 2011 Jul 20; 29(25). PMID: 21768458    Free PMC article.
Highly Cited.
Protein expression, survival and docetaxel benefit in node-positive breast cancer treated with adjuvant chemotherapy in the FNCLCC-PACS 01 randomized trial.
Jocelyne Jacquemier, Jean-Marie Boher, +12 authors, François Bertucci.
Breast Cancer Res, 2011 Nov 03; 13(6). PMID: 22044691    Free PMC article.
Sequential adjuvant epirubicin-based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 Trial.
Henri Roché, Pierre Fumoleau, +17 authors, Bernard Asselain.
J Clin Oncol, 2006 Nov 23; 24(36). PMID: 17116941
Highly Cited.
Mortality, leukemic risk, and cardiovascular toxicity of adjuvant anthracycline and taxane chemotherapy in breast cancer: a meta-analysis.
Fausto Petrelli, Karen Borgonovo, +2 authors, Sandro Barni.
Breast Cancer Res Treat, 2012 Jun 13; 135(2). PMID: 22689092
Review.
Evaluation of trastuzumab without chemotherapy as a post-operative adjuvant therapy in HER2-positive elderly breast cancer patients: randomized controlled trial [RESPECT (N-SAS BC07)].
Masataka Sawaki, Nahomi Tokudome, +9 authors, Yasuo Ohashi.
Jpn J Clin Oncol, 2011 Mar 01; 41(5). PMID: 21355003
C-MYC alterations and association with patient outcome in early-stage HER2-positive breast cancer from the north central cancer treatment group N9831 adjuvant trastuzumab trial.
Edith A Perez, Robert B Jenkins, +20 authors, Monica M Reinholz.
J Clin Oncol, 2011 Jan 20; 29(6). PMID: 21245420    Free PMC article.
The practice guidelines development cycle: a conceptual tool for practice guidelines development and implementation.
G P Browman, M N Levine, +4 authors, A Laupacis.
J Clin Oncol, 1995 Feb 01; 13(2). PMID: 7844612
Highly Cited.
Docetaxel With Cyclophosphamide Is Associated With an Overall Survival Benefit Compared With Doxorubicin and Cyclophosphamide: 7-Year Follow-Up of US Oncology Research Trial 9735.
Stephen Jones, Frankie Ann Holmes, +17 authors, Michael A Savin.
J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204201
Highly Cited.
Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial.
Judith Hugh, John Hanson, +11 authors, Charles Vogel.
J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204205    Free PMC article.
Highly Cited.
Disease-free survival according to degree of HER2 amplification for patients treated with adjuvant chemotherapy with or without 1 year of trastuzumab: the HERA Trial.
Mitch Dowsett, Marion Procter, +11 authors, Brian Leyland-Jones.
J Clin Oncol, 2009 Apr 15; 27(18). PMID: 19364966    Free PMC article.
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
Effect of screening and adjuvant therapy on mortality from breast cancer.
Donald A Berry, Kathleen A Cronin, +8 authors, Cancer Intervention and Surveillance Modeling Network (CISNET) Collaborators.
N Engl J Med, 2005 Oct 28; 353(17). PMID: 16251534
Highly Cited.
Adjuvant chemotherapy in older women with early-stage breast cancer.
Hyman B Muss, Donald A Berry, +23 authors, CALGB Investigators.
N Engl J Med, 2009 May 15; 360(20). PMID: 19439741    Free PMC article.
Highly Cited.
Population-based validation of the prognostic model ADJUVANT! for early breast cancer.
Ivo A Olivotto, Chris D Bajdik, +6 authors, Karen A Gelmon.
J Clin Oncol, 2005 Apr 20; 23(12). PMID: 15837986
Highly Cited.
Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial.
Christina Davies, Hongchao Pan, +36 authors, Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group.
Lancet, 2012 Dec 12; 381(9869). PMID: 23219286    Free PMC article.
Highly Cited.
American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
M Elizabeth H Hammond, Daniel F Hayes, +2 authors, Sarah Temin.
J Oncol Pract, 2010 Nov 03; 6(4). PMID: 21037871    Free PMC article.
Highly Cited.
Predictability of adjuvant trastuzumab benefit in N9831 patients using the ASCO/CAP HER2-positivity criteria.
Edith A Perez, Amylou C Dueck, +9 authors, Beiyun Chen.
J Natl Cancer Inst, 2011 Dec 06; 104(2). PMID: 22138096    Free PMC article.
Weekly paclitaxel in the adjuvant treatment of breast cancer.
Joseph A Sparano, Molin Wang, +7 authors, Nancy E Davidson.
N Engl J Med, 2008 Apr 19; 358(16). PMID: 18420499    Free PMC article.
Highly Cited.
Adjuvant chemotherapy followed by goserelin versus either modality alone for premenopausal lymph node-negative breast cancer: a randomized trial.
International Breast Cancer Study Group (IBCSG), Monica Castiglione-Gertsch, +7 authors, Richard D Gelber.
J Natl Cancer Inst, 2003 Dec 18; 95(24). PMID: 14679153
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
M Elizabeth H Hammond, Daniel F Hayes, +29 authors, Antonio C Wolff.
Arch Pathol Lab Med, 2010 Jun 09; 134(6). PMID: 20524868    Free PMC article.
Highly Cited.
Adjuvant ovarian suppression in premenopausal breast cancer.
Prudence A Francis, Meredith M Regan, +28 authors, International Breast Cancer Study Group.
N Engl J Med, 2014 Dec 17; 372(5). PMID: 25495490    Free PMC article.
Highly Cited.
Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer.
Susan E Minton, Pamela N Munster.
Cancer Control, 2003 Jan 07; 9(6). PMID: 12514564
Review.
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version).
M Elizabeth H Hammond, Daniel F Hayes, +31 authors, College of American Pathologists.
Arch Pathol Lab Med, 2010 Jul 01; 134(7). PMID: 20586616
Highly Cited. Systematic Review.
Late tamoxifen in patients previously operated for breast cancer without postoperative tamoxifen: 5-year results of a single institution randomised study.
Andrea Veronesi, Gianmaria Miolo, +4 authors, Davide Lombardi.
BMC Cancer, 2010 May 18; 10. PMID: 20470379    Free PMC article.
Breast cancer management in low resource countries (LRCs): consensus statement from the Breast Health Global Initiative.
Nagi S El Saghir, Clement A Adebamowo, +14 authors, Eduardo Cazap.
Breast, 2011 Mar 12; 20 Suppl 2. PMID: 21392996
The role of lymphovascular invasion as a prognostic factor in patients with lymph node-positive operable invasive breast cancer.
Young Ju Song, Sun Hyoung Shin, +3 authors, Young Jong Jegal.
J Breast Cancer, 2011 Oct 28; 14(3). PMID: 22031801    Free PMC article.
Effect of the anti-oestrogen tamoxifen on plasma levels of luteinizing hormone, follicle-stimulating hormone, prolactin, oestradiol and progesterone in normal pre-menopausal women.
G V Groom, K Griffiths.
J Endocrinol, 1976 Sep 01; 70(3). PMID: 978103
Cyclophosphamide, epirubicin, and Fluorouracil versus dose-dense epirubicin and cyclophosphamide followed by Paclitaxel versus Doxorubicin and cyclophosphamide followed by Paclitaxel in node-positive or high-risk node-negative breast cancer.
Margot Burnell, Mark N Levine, +11 authors, Lois E Shepherd.
J Clin Oncol, 2009 Nov 11; 28(1). PMID: 19901117    Free PMC article.
Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27.
Priya Rastogi, Stewart J Anderson, +15 authors, Norman Wolmark.
J Clin Oncol, 2008 Feb 09; 26(5). PMID: 18258986
Highly Cited.
Breast cancer management in middle-resource countries (MRCs): consensus statement from the Breast Health Global Initiative.
Cheng-Har Yip, Eduardo Cazap, +17 authors, Hussein M Khaled.
Breast, 2011 Mar 11; 20 Suppl 2. PMID: 21388811
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.
Kathy S Albain, William E Barlow, +20 authors, Breast Cancer Intergroup of North America.
Lancet Oncol, 2009 Dec 17; 11(1). PMID: 20005174    Free PMC article.
Highly Cited.
Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.
Antonio C Wolff, M Elizabeth H Hammond, +19 authors, College of American Pathologists.
J Clin Oncol, 2013 Oct 09; 31(31). PMID: 24101045
Highly Cited.
Progress of clinical oncology guidelines development using the Practice Guidelines Development Cycle: the role of practitioner feedback.
G P Browman, T E Newman, +8 authors, D H Cowan.
J Clin Oncol, 1998 Mar 21; 16(3). PMID: 9508211
Prognostic factors affecting the natural history of node-negative breast cancer.
Maureen E Trudeau, Kathleen I Pritchard, +8 authors, H Lavina Lickley.
Breast Cancer Res Treat, 2005 Jan 25; 89(1). PMID: 15666195
Phase III comparison of tamoxifen versus tamoxifen plus ovarian function suppression in premenopausal women with node-negative, hormone receptor-positive breast cancer (E-3193, INT-0142): a trial of the Eastern Cooperative Oncology Group.
Amye J Tevaarwerk, Molin Wang, +9 authors, Nicholas J Robert.
J Clin Oncol, 2014 Oct 29; 32(35). PMID: 25349302    Free PMC article.
Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial.
Heikki Joensuu, Petri Bono, +17 authors, Pirkko-Liisa Kellokumpu-Lehtinen.
J Clin Oncol, 2009 Nov 04; 27(34). PMID: 19884557
Highly Cited.
FOXP3 expression in cancer cells and anthracyclines efficacy in patients with primary breast cancer treated with adjuvant chemotherapy in the phase III UNICANCER-PACS 01 trial.
S Ladoire, G Mignot, +15 authors, F Ghiringhelli.
Ann Oncol, 2012 Mar 21; 23(10). PMID: 22431701
Selection of adjuvant chemotherapy for treatment of node-positive breast cancer.
Maureen Trudeau, Flay Charbonneau, +7 authors, Shailendra Verma.
Lancet Oncol, 2005 Nov 01; 6(11). PMID: 16257797
Review.
Extended benefit from sequential administration of docetaxel after standard fluorouracil, epirubicin, and cyclophosphamide regimen for node-positive breast cancer: the 8-year follow-up results of the UNICANCER-PACS01 trial.
Bruno Coudert, Bernard Asselain, +18 authors, UNICANCER Breast Group.
Oncologist, 2012 May 23; 17(7). PMID: 22610153    Free PMC article.
American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
M Elizabeth H Hammond, Daniel F Hayes, +29 authors, Antonio C Wolff.
J Clin Oncol, 2010 Apr 21; 28(16). PMID: 20404251    Free PMC article.
Highly Cited. Systematic Review.
Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
E Senkus, S Kyriakides, +5 authors, ESMO Guidelines Working Group.
Ann Oncol, 2013 Aug 24; 24 Suppl 6. PMID: 23970019
Highly Cited.
Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial.
Edith A Perez, Vera J Suman, +12 authors, Richard J Rodeheffer.
J Clin Oncol, 2008 Feb 06; 26(8). PMID: 18250349    Free PMC article.
Highly Cited.
BCIRG 001 molecular analysis: prognostic factors in node-positive breast cancer patients receiving adjuvant chemotherapy.
Charles Dumontet, Maryla Krajewska, +5 authors, John C Reed.
Clin Cancer Res, 2010 Jun 26; 16(15). PMID: 20576719
Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial.
M Untch, R D Gelber, +26 authors, HERA Study Team.
Ann Oncol, 2008 Feb 26; 19(6). PMID: 18296421
Prolactin-induced protein as a potential therapy response marker of adjuvant chemotherapy in breast cancer patients.
Karolina Jablonska, Jedrzej Grzegrzolka, +10 authors, Piotr Dziegiel.
Am J Cancer Res, 2016 Jun 14; 6(5). PMID: 27293986    Free PMC article.
Prospective Evaluation of the Impact of the 21-Gene Recurrence Score Assay on Adjuvant Treatment Decisions for Women with Node-Positive Breast Cancer in Ontario, Canada.
Sofia Torres, Maureen Trudeau, +7 authors, Andrea Eisen.
Oncologist, 2018 Jan 27; 23(7). PMID: 29371476    Free PMC article.
Advances in the systemic treatment of triple-negative breast cancer.
J M Lebert, R Lester, +2 authors, J McCarthy.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910657    Free PMC article.
Highly Cited. Review.
Clinical practice guidelines in breast cancer.
N Kumar Tyagi, S Dhesy-Thind.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910658    Free PMC article.
Review.
Lymph Node Status in Breast Cancer Does Not Predict Tumor Biology.
Danielle M Bello, Christy Russell, +2 authors, Monica Morrow.
Ann Surg Oncol, 2018 Jul 04; 25(10). PMID: 29968028    Free PMC article.
Medical Care Costs for Recurrent versus De Novo Stage IV Cancer by Age at Diagnosis.
Debra P Ritzwoller, Paul A Fishman, +6 authors, Michael J Hassett.
Health Serv Res, 2018 Jul 26; 53(6). PMID: 30043542    Free PMC article.
Herceptin® (trastuzumab) in HER2-positive early breast cancer: a systematic review and cumulative network meta-analysis.
Florence R Wilson, Megan E Coombes, +7 authors, Chris Cameron.
Syst Rev, 2018 Nov 16; 7(1). PMID: 30428932    Free PMC article.
Systematic Review.
Spending for Advanced Cancer Diagnoses: Comparing Recurrent Versus De Novo Stage IV Disease.
Michael J Hassett, Matthew Banegas, +6 authors, Debra P Ritzwoller.
J Oncol Pract, 2019 May 21; 15(7). PMID: 31107629    Free PMC article.
Vertebral bone marrow fat fraction changes in postmenopausal women with breast cancer receiving combined aromatase inhibitor and bisphosphonate therapy.
Michael Dieckmeyer, Stefan Ruschke, +10 authors, Thomas Baum.
BMC Musculoskelet Disord, 2019 Nov 07; 20(1). PMID: 31694630    Free PMC article.
Cost-utility analysis of 21-gene assay for node-positive early breast cancer.
L Masucci, S Torres, +5 authors, W Isaranuwatchai.
Curr Oncol, 2019 Nov 12; 26(5). PMID: 31708649    Free PMC article.
Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer: A Health Technology Assessment.
Ontario Health (Quality).
Ont Health Technol Assess Ser, 2020 Apr 15; 20(10). PMID: 32284770    Free PMC article.
Management of hormone receptor-positive, HER2-negative early breast cancer.
Elaine M Walsh, Karen L Smith, Vered Stearns.
Semin Oncol, 2020 Jun 18; 47(4). PMID: 32546323    Free PMC article.
Review.
Four cycles of docetaxel and cyclophosphamide as adjuvant chemotherapy in node negative breast cancer: A real-world study.
Atul Batra, Malek B Hannouf, Noura Alsafar, Sasha Lupichuk.
Breast, 2020 Aug 31; 54. PMID: 32861882    Free PMC article.
Adjuvant Chemotherapy for Patients with Breast Cancer Based on Clinical and Evolving Oncotype DX Criteria.
Jamal Zekri, Meteb Al-Foheidi, +2 authors, Ayman Rasmy.
Breast Care (Basel), 2021 Jan 16; 15(6). PMID: 33447239    Free PMC article.
The increasing importance of histologic grading in tailoring adjuvant systemic therapy in 30,843 breast cancer patients.
C van Dooijeweert, I O Baas, +3 authors, E van der Wall.
Breast Cancer Res Treat, 2021 Feb 01;. PMID: 33517555
A population-based comparison of treatment patterns, resource utilization, and costs by cancer stage for Ontario patients with hormone receptor-positive/HER2-negative breast cancer.
Christine Brezden-Masley, Kelly E Fathers, +3 authors, Katarzyna J Jerzak.
Breast Cancer Res Treat, 2020 Oct 17; 185(2). PMID: 33064230    Free PMC article.