. 2015 Apr;17().
doi: 10.1186/s13058-015-0514-2.

Multigene prognostic tests in breast cancer: past, present, future

Balázs Győrffy  Christos Hatzis  Tara Sanft  Erin Hofstatter  Bilge Aktas  Lajos Pusztai  
  • PMID: 25848861
  •     31 References
  •     80 citations


There is growing consensus that multigene prognostic tests provide useful complementary information to tumor size and grade in estrogen receptor (ER)-positive breast cancers. The tests primarily rely on quantification of ER and proliferation-related genes and combine these into multivariate prediction models. Since ER-negative cancers tend to have higher proliferation rates, the prognostic value of current multigene tests in these cancers is limited. First-generation prognostic signatures (Oncotype DX, MammaPrint, Genomic Grade Index) are substantially more accurate to predict recurrence within the first 5 years than in later years. This has become a limitation with the availability of effective extended adjuvant endocrine therapies. Newer tests (Prosigna, EndoPredict, Breast Cancer Index) appear to possess better prognostic value for late recurrences while also remaining predictive of early relapse. Some clinical prediction problems are more difficult to solve than others: there are no clinically useful prognostic signatures for ER-negative cancers, and drug-specific treatment response predictors also remain elusive. Emerging areas of research involve the development of immune gene signatures that carry modest but significant prognostic value independent of proliferation and ER status and represent candidate predictive markers for immune-targeted therapies. Overall metrics of tumor heterogeneity and genome integrity (for example, homologue recombination deficiency score) are emerging as potential new predictive markers for platinum agents. The recent expansion of high-throughput technology platforms including low-cost sequencing of circulating and tumor-derived DNA and RNA and rapid reliable quantification of microRNA offers new opportunities to build extended prediction models across multiplatform data.

Prediction of the Oncotype DX recurrence score: use of pathology-generated equations derived by linear regression analysis.
Molly E Klein, David J Dabbs, +4 authors, Rohit Bhargava.
Mod Pathol, 2013 Mar 19; 26(5). PMID: 23503643    Free PMC article.
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer.
V Abkevich, K M Timms, +17 authors, J S Lanchbury.
Br J Cancer, 2012 Oct 11; 107(10). PMID: 23047548    Free PMC article.
Highly Cited.
The 70-gene prognosis-signature predicts disease outcome in breast cancer patients with 1-3 positive lymph nodes in an independent validation study.
Stella Mook, Marjanka K Schmidt, +10 authors, TRANSBIG Consortium.
Breast Cancer Res Treat, 2008 Jul 29; 116(2). PMID: 18661261
Comparison of PAM50 risk of recurrence score with oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy.
Mitch Dowsett, Ivana Sestak, +7 authors, Jack Cuzick.
J Clin Oncol, 2013 Jul 03; 31(22). PMID: 23816962
Highly Cited.
Lack of sufficiently strong informative features limits the potential of gene expression analysis as predictive tool for many clinical classification problems.
Kenneth R Hess, Caimiao Wei, +3 authors, Lajos Pusztai.
BMC Bioinformatics, 2011 Dec 03; 12. PMID: 22132775    Free PMC article.
A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors.
Martin Filipits, Margaretha Rudas, +25 authors, EP Investigators.
Clin Cancer Res, 2011 Aug 03; 17(18). PMID: 21807638
Highly Cited.
Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer.
Jack Cuzick, Mitch Dowsett, +10 authors, John F Forbes.
J Clin Oncol, 2011 Oct 13; 29(32). PMID: 21990413
Highly Cited.
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Therese Sorlie, Robert Tibshirani, +13 authors, David Botstein.
Proc Natl Acad Sci U S A, 2003 Jun 28; 100(14). PMID: 12829800    Free PMC article.
Highly Cited.
Improvement of the clinical applicability of the Genomic Grade Index through a qRT-PCR test performed on frozen and formalin-fixed paraffin-embedded tissues.
Jérôme Toussaint, Anieta M Sieuwerts, +8 authors, Christos Sotiriou.
BMC Genomics, 2009 Sep 12; 10. PMID: 19744330    Free PMC article.
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
Lyndsay Harris, Herbert Fritsche, +7 authors, American Society of Clinical Oncology.
J Clin Oncol, 2007 Oct 24; 25(33). PMID: 17954709
Highly Cited. Review.
Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer.
Rachel C Jankowitz, Kristine Cooper, +5 authors, Adam Brufsky.
Breast Cancer Res, 2011 Oct 18; 13(5). PMID: 21999244    Free PMC article.
Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer.
Cornelia Liedtke, Chafika Mazouni, +10 authors, Lajos Pusztai.
J Clin Oncol, 2008 Feb 06; 26(8). PMID: 18250347
Highly Cited.
First generation prognostic gene signatures for breast cancer predict both survival and chemotherapy sensitivity and identify overlapping patient populations.
Takayuki Iwamoto, Ju-Seog Lee, +7 authors, Lajos Pusztai.
Breast Cancer Res Treat, 2011 Aug 13; 130(1). PMID: 21833625
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.
Christos Hatzis, Lajos Pusztai, +27 authors, W Fraser Symmans.
JAMA, 2011 May 12; 305(18). PMID: 21558518    Free PMC article.
Highly Cited.
Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents.
Nicolai J Birkbak, Zhigang C Wang, +13 authors, Andrea L Richardson.
Cancer Discov, 2012 May 12; 2(4). PMID: 22576213    Free PMC article.
Highly Cited.
EndoPredict improves the prognostic classification derived from common clinical guidelines in ER-positive, HER2-negative early breast cancer.
P Dubsky, M Filipits, +17 authors, Austrian Breast and Colorectal Cancer Study Group (ABCSG).
Ann Oncol, 2012 Oct 05; 24(3). PMID: 23035151    Free PMC article.
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population.
Dennis C Sgroi, Ivana Sestak, +9 authors, Mitch Dowsett.
Lancet Oncol, 2013 Sep 17; 14(11). PMID: 24035531    Free PMC article.
Highly Cited.
Agreement in risk prediction between the 21-gene recurrence score assay (Oncotype DX®) and the PAM50 breast cancer intrinsic Classifier™ in early-stage estrogen receptor-positive breast cancer.
Catherine M Kelly, Philip S Bernard, +7 authors, Lajos Pusztai.
Oncologist, 2012 Mar 16; 17(4). PMID: 22418568    Free PMC article.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer.
Xiao-Jun Ma, Ranelle Salunga, +8 authors, Dennis Sgroi.
Clin Cancer Res, 2008 May 03; 14(9). PMID: 18451222
A prospective evaluation of a breast cancer prognosis signature in the observational RASTER study.
C A Drukker, J M Bueno-de-Mesquita, +10 authors, S C Linn.
Int J Cancer, 2013 Feb 02; 133(4). PMID: 23371464    Free PMC article.
Gene-expression signatures in breast cancer.
Christos Sotiriou, Lajos Pusztai.
N Engl J Med, 2009 Feb 21; 360(8). PMID: 19228622
Highly Cited. Review.
The EndoPredict Gene-Expression Assay in Clinical Practice - Performance and Impact on Clinical Decisions.
Berit Maria Müller, Elke Keil, +16 authors, Carsten Denkert.
PLoS One, 2013 Jul 05; 8(6). PMID: 23826382    Free PMC article.
The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer.
Michael Knauer, Stella Mook, +7 authors, Laura J van 't Veer.
Breast Cancer Res Treat, 2010 Mar 06; 120(3). PMID: 20204499
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis.
Christos Sotiriou, Pratyaksha Wirapati, +17 authors, Mauro Delorenzi.
J Natl Cancer Inst, 2006 Feb 16; 98(4). PMID: 16478745
Highly Cited.
Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98.
Sherene Loi, Nicolas Sirtaine, +13 authors, Christos Sotiriou.
J Clin Oncol, 2013 Jan 24; 31(7). PMID: 23341518
Highly Cited.
A gene-expression signature as a predictor of survival in breast cancer.
Marc J van de Vijver, Yudong D He, +18 authors, René Bernards.
N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681
Highly Cited.
Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue.
Lorenza Mittempergher, Jorma J de Ronde, +5 authors, Laura J Van't Veer.
PLoS One, 2011 Feb 25; 6(2). PMID: 21347257    Free PMC article.
Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen.
A Prat, J S Parker, +9 authors, C M Perou.
Ann Oncol, 2012 Apr 26; 23(11). PMID: 22532584    Free PMC article.
Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers.
Giampaolo Bianchini, Yuan Qi, +13 authors, Lajos Pusztai.
J Clin Oncol, 2010 Sep 02; 28(28). PMID: 20805453
Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients.
Brian Z Ring, David R Hout, +6 authors, Robert S Seitz.
BMC Cancer, 2016 Feb 26; 16. PMID: 26908167    Free PMC article.
Application of cancer-associated glycoforms and glycan-binding probes to an in vitro diagnostic multivariate index assay for precise diagnoses of cancer.
Jeong Gu Kang, Jeong-Heon Ko, Yong-Sam Kim.
Proteomics, 2016 Mar 24; 16(24). PMID: 27005968    Free PMC article.
Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids.
Kathrin Halfter, Oliver Hoffmann, +6 authors, Barbara Mayer.
J Transl Med, 2016 May 05; 14(1). PMID: 27142386    Free PMC article.
Intratumor Heterogeneity Affects Gene Expression Profile Test Prognostic Risk Stratification in Early Breast Cancer.
Rekha Gyanchandani, Yan Lin, +10 authors, Adrian V Lee.
Clin Cancer Res, 2016 Nov 03; 22(21). PMID: 27185370    Free PMC article.
Chromatin Regulators as a Guide for Cancer Treatment Choice.
Zachary A Gurard-Levin, Laurence O W Wilson, +9 authors, Geneviève Almouzni.
Mol Cancer Ther, 2016 May 20; 15(7). PMID: 27196757    Free PMC article.
The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancers.
Gajendra Shrestha, Shelley M MacNeil, +3 authors, Andrea H Bild.
Semin Cell Dev Biol, 2016 Jun 25; 58. PMID: 27338857    Free PMC article.
Identification of novel biomarkers associated with poor patient outcomes in invasive breast carcinoma.
Renata A Canevari, Fabio A Marchi, +5 authors, Eduardo M Reis.
Tumour Biol, 2016 Aug 04; 37(10). PMID: 27485113
Breast carcinoma with an Oncotype Dx recurrence score <18: Rate of distant metastases in a large series with clinical follow-up.
Hannah Y Wen, Melissa Krystel-Whittemore, +7 authors, Edi Brogi.
Cancer, 2016 Aug 16; 123(1). PMID: 27526056    Free PMC article.
Towards tumor immunodiagnostics.
Helen Kourea, Vassiliki Kotoula.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563650    Free PMC article.
SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer.
Lauren L Siewertsz van Reesema, Vasilena Zheleva, +17 authors, Amy H Tang.
EBioMedicine, 2016 Aug 30; 11. PMID: 27569656    Free PMC article.
Decoding the usefulness of non-coding RNAs as breast cancer markers.
Maria Amorim, Sofia Salta, Rui Henrique, Carmen Jerónimo.
J Transl Med, 2016 Sep 16; 14. PMID: 27629831    Free PMC article.
Transcriptome Analysis Identifies the Dysregulation of Ultraviolet Target Genes in Human Skin Cancers.
Yao Shen, Arianna L Kim, Rong Du, Liang Liu.
PLoS One, 2016 Sep 20; 11(9). PMID: 27643989    Free PMC article.
Renewed interest in the progesterone receptor in breast cancer.
Elgene Lim, Carlo Palmieri, Wayne D Tilley.
Br J Cancer, 2016 Sep 23; 115(8). PMID: 27657336    Free PMC article.
Colon cancer subtypes: concordance, effect on survival and selection of the most representative preclinical models.
Zsófia Sztupinszki, Balázs Győrffy.
Sci Rep, 2016 Nov 17; 6. PMID: 27849044    Free PMC article.
Predictors of Chemosensitivity in Triple Negative Breast Cancer: An Integrated Genomic Analysis.
Tingting Jiang, Weiwei Shi, +8 authors, Christos Hatzis.
PLoS Med, 2016 Dec 14; 13(12). PMID: 27959926    Free PMC article.
A pilot study on plasma levels of micro-RNAs involved in angiogenesis and vascular maturation in patients with breast cancer.
Emmanuel Kontomanolis, Achilleas Mitrakas, +4 authors, Michael I Koukourakis.
Med Oncol, 2017 Jan 07; 34(2). PMID: 28058628
Low utility of Oncotype DX® in the clinic.
Luisel J Ricks-Santi, John Tyson McDonald.
Cancer Med, 2017 Feb 02; 6(3). PMID: 28145091    Free PMC article.
Neoadjuvant therapy for treatment of breast cancer: the way forward, or simply a convenient option for patients?
Abhishek Chatterjee, John K Erban.
Gland Surg, 2017 Feb 18; 6(1). PMID: 28210563    Free PMC article.
Detecting gene signature activation in breast cancer in an absolute, single-patient manner.
E R Paquet, R Lesurf, +2 authors, M T Hallett.
Breast Cancer Res, 2017 Mar 23; 19(1). PMID: 28327201    Free PMC article.
Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy.
Sacha Gnjatic, Vincenzo Bronte, +13 authors, Lisa H Butterfield.
J Immunother Cancer, 2017 May 19; 5. PMID: 28515944    Free PMC article.
Highly Cited. Review.
Improving accuracy of RNA-based diagnosis and prognosis of oral cancer by using noninvasive methods.
Guy R Adami, Jessica L Tang, Michael R Markiewicz.
Oral Oncol, 2017 Jun 01; 69. PMID: 28559022    Free PMC article.
RAS pathway biomarkers for breast cancer prognosis.
Lauren L Siewertsz van Reesema, Michael P Lee, +5 authors, Amy H Tang.
Clin Lab Int, 2017 Jun 06; 40. PMID: 28579913    Free PMC article.
21-Gene recurrence score and locoregional recurrence in lymph node-negative, estrogen receptor-positive breast cancer.
Gulisa Turashvili, Joanne F Chou, +5 authors, Hannah Y Wen.
Breast Cancer Res Treat, 2017 Jul 14; 166(1). PMID: 28702894    Free PMC article.
Heterogeneous Enhancement Patterns of Tumor-adjacent Parenchyma at MR Imaging Are Associated with Dysregulated Signaling Pathways and Poor Survival in Breast Cancer.
Jia Wu, Bailiang Li, +6 authors, Ruijiang Li.
Radiology, 2017 Jul 15; 285(2). PMID: 28708462    Free PMC article.
Genomic approaches to accelerate cancer interception.
Jennifer Beane, Joshua D Campbell, +2 authors, Avrum Spira.
Lancet Oncol, 2017 Aug 02; 18(8). PMID: 28759388    Free PMC article.
E-cadherin expression phenotypes associated with molecular subtypes in invasive non-lobular breast cancer: evidence from a retrospective study and meta-analysis.
Jiang-Bo Liu, Chen-Yi Feng, +4 authors, Xiao-Shan Feng.
World J Surg Oncol, 2017 Aug 03; 15(1). PMID: 28764784    Free PMC article.
MammaPrint versus EndoPredict: Poor correlation in disease recurrence risk classification of hormone receptor positive breast cancer.
Andreas Bösl, Andreas Spitzmüller, +3 authors, Felix Offner.
PLoS One, 2017 Aug 30; 12(8). PMID: 28850621    Free PMC article.
Functional proteomics outlines the complexity of breast cancer molecular subtypes.
Angelo Gámez-Pozo, Lucía Trilla-Fuertes, +18 authors, Juan Ángel Fresno Vara.
Sci Rep, 2017 Sep 01; 7(1). PMID: 28855612    Free PMC article.
TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-κB Signaling.
Hidetaka Kawabata, Kotaro Azuma, +7 authors, Satoshi Inoue.
Int J Mol Sci, 2017 Sep 09; 18(9). PMID: 28885545    Free PMC article.
Comparison of risk classification between EndoPredict and MammaPrint in ER-positive/HER2-negative primary invasive breast cancer.
Alberto Peláez-García, Laura Yébenes, +9 authors, David Hardisson.
PLoS One, 2017 Sep 09; 12(9). PMID: 28886093    Free PMC article.
Copy Number Profiling of MammaPrint™ Genes Reveals Association with the Prognosis of Breast Cancer Patients.
Areej Fatima, Fomaz Tariq, +2 authors, Farhan Haq.
J Breast Cancer, 2017 Oct 04; 20(3). PMID: 28970850    Free PMC article.
DUSP4 is associated with increased resistance against anti-HER2 therapy in breast cancer.
Otília Menyhart, Jan Budczies, +4 authors, Balázs Győrffy.
Oncotarget, 2017 Nov 05; 8(44). PMID: 29100381    Free PMC article.
The Era of Multigene Panels Comes? The Clinical Utility of Oncotype DX and MammaPrint.
Ling Xin, Yin-Hua Liu, Tracey A Martin, Wen G Jiang.
World J Oncol, 2017 Nov 18; 8(2). PMID: 29147432    Free PMC article.
Molecular Genomic Testing for Breast Cancer: Utility for Surgeons.
Oluwadamilola M Fayanju, Ko Un Park, Anthony Lucci.
Ann Surg Oncol, 2017 Nov 22; 25(2). PMID: 29159748    Free PMC article.
MRI texture analysis in differentiating luminal A and luminal B breast cancer molecular subtypes - a feasibility study.
Kirsi Holli-Helenius, Annukka Salminen, +4 authors, Riitta Parkkola.
BMC Med Imaging, 2017 Dec 30; 17(1). PMID: 29284425    Free PMC article.
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer.
Satbir Singh Thakur, Haocheng Li, +5 authors, Hua Yang.
PLoS One, 2018 Jan 06; 13(1). PMID: 29304138    Free PMC article.
Breast carcinoma with 21-gene recurrence score lower than 18: rate of locoregional recurrence in a large series with clinical follow-up.
Gulisa Turashvili, Edi Brogi, +4 authors, Hannah Y Wen.
BMC Cancer, 2018 Jan 07; 18(1). PMID: 29304773    Free PMC article.
Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway.
Mengwei Li, Yanzhen Han, +6 authors, Hanmei Xu.
Cell Death Dis, 2018 Jan 26; 9(2). PMID: 29367600    Free PMC article.
MicroRNA expression in benign breast tissue and risk of subsequent invasive breast cancer.
Thomas Rohan, Kenny Ye, +3 authors, Olivier Loudig.
PLoS One, 2018 Feb 13; 13(2). PMID: 29432432    Free PMC article.
Association of miR-548c-5p, miR-7-5p, miR-210-3p, miR-128-3p with recurrence in systemically untreated breast cancer.
Ines Block, Mark Burton, +7 authors, Torben A Kruse.
Oncotarget, 2018 Mar 07; 9(10). PMID: 29507672    Free PMC article.
Molecular prediction of adjuvant cisplatin efficacy in Non-Small Cell Lung Cancer (NSCLC)-validation in two independent cohorts.
Ida Kappel Buhl, Eric Santoni-Rugiu, +8 authors, Jens Benn Sørensen.
PLoS One, 2018 Mar 23; 13(3). PMID: 29566065    Free PMC article.
Methylation-to-Expression Feature Models of Breast Cancer Accurately Predict Overall Survival, Distant-Recurrence Free Survival, and Pathologic Complete Response in Multiple Cohorts.
Jeffrey A Thompson, Brock C Christensen, Carmen J Marsit.
Sci Rep, 2018 Mar 28; 8(1). PMID: 29581450    Free PMC article.
Clinicopathologic Factors Related to the Histological Tumor Grade of Breast Cancer in Western China: An Epidemiological Multicenter Study of 8619 Female Patients.
Ke Zheng, Jin-Xiang Tan, +21 authors, Guo-Sheng Ren.
Transl Oncol, 2018 Jul 10; 11(4). PMID: 29982100    Free PMC article.
Copy number profiling of Oncotype DX genes reveals association with survival of breast cancer patients.
Washaakh Ahmed, Muhammad Faraz Arshad Malik, Muhammad Saeed, Farhan Haq.
Mol Biol Rep, 2018 Sep 19; 45(6). PMID: 30225582
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers.
André Filipe Vieira, Fernando Schmitt.
Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119    Free PMC article.
BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer.
Mi Jeong Kwon, Sae Byul Lee, +8 authors, Young Kee Shin.
PLoS One, 2018 Nov 22; 13(11). PMID: 30462685    Free PMC article.
Clinical Molecular Marker Testing Data Capture to Promote Precision Medicine Research Within the Cancer Research Network.
Andrea N Burnett-Hartman, Natalia Udaltsova, +13 authors, Christine Y Lu.
JCO Clin Cancer Inform, 2019 Sep 06; 3. PMID: 31487201    Free PMC article.
Droplet digital polymerase chain reaction offers an improvisation over conventional immunohistochemistry and fluorescent in situ hybridization for ascertaining Her2 status of breast cancer.
Moushumi Suryavanshi, Jiten Jaipuria, +8 authors, Bhudev C Das.
South Asian J Cancer, 2019 Dec 07; 8(4). PMID: 31807475    Free PMC article.
Imaging Phenotypes of Breast Cancer Heterogeneity in Preoperative Breast Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) Scans Predict 10-Year Recurrence.
Rhea D Chitalia, Jennifer Rowland, +7 authors, Despina Kontos.
Clin Cancer Res, 2019 Nov 17; 26(4). PMID: 31732521    Free PMC article.
Use and Impact of the 21-Gene Recurrence Score in Relation to the Clinical Risk of Developing Metastases in Early Breast Cancer Patients in the Netherlands.
Kay Schreuder, Anne Kuijer, +2 authors, Sabine Siesling.
Public Health Genomics, 2019 Jan 17; 21(1-2). PMID: 30650410    Free PMC article.
A biological function based biomarker panel optimization process.
Min Young Lee, Taek-Kyun Kim, Kathie-Anne Walters, Kai Wang.
Sci Rep, 2019 May 16; 9(1). PMID: 31089177    Free PMC article.
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Sisi Wang, Tiffany M Scharadin, +5 authors, Paul T Henderson.
Chem Res Toxicol, 2018 Nov 02; 31(12). PMID: 30381944    Free PMC article.
Molecular approaches to the diagnosis and monitoring of production diseases in pigs.
Timothy A Giles, Aouatif Belkhiri, Paul A Barrow, Neil Foster.
Res Vet Sci, 2017 May 24; 114. PMID: 28535467    Free PMC article.
Highly robust model of transcription regulator activity predicts breast cancer overall survival.
Chuanpeng Dong, Jiannan Liu, +6 authors, Yunlong Liu.
BMC Med Genomics, 2020 Apr 04; 13(Suppl 5). PMID: 32241272    Free PMC article.
MiR-891a-5p as a prognostic marker and therapeutic target for hormone receptor-positive breast cancer.
Zhiqiang Zhang, Lu Xu, +7 authors, Xiujuan Qu.
J Cancer, 2020 Apr 25; 11(13). PMID: 32328182    Free PMC article.
Uncovering the prognostic gene signatures for the improvement of risk stratification in cancers by using deep learning algorithm coupled with wavelet transform.
Yiru Zhao, Yifan Zhou, +5 authors, Zhining Wen.
BMC Bioinformatics, 2020 May 21; 21(1). PMID: 32429941    Free PMC article.
Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer.
Gagan Gupta, Caroline Dasom Lee, +10 authors, Amy H Tang.
Ann Breast Cancer Ther, 2020 Jun 17; 4(1). PMID: 32542231    Free PMC article.
Differences in Gene Expression Profile of Primary Tumors in Metastatic and Non-Metastatic Papillary Thyroid Carcinoma-Do They Exist?
Sylwia Szpak-Ulczok, Aleksandra Pfeifer, +16 authors, Jolanta Krajewska.
Int J Mol Sci, 2020 Jul 03; 21(13). PMID: 32610693    Free PMC article.
Neoadjuvant endocrine therapy in locally advanced estrogen or progesterone receptor-positive breast cancer: determining the optimal endocrine agent and treatment duration in postmenopausal women-a literature review and proposed guidelines.
Lauren I Madigan, Phuong Dinh, J Dinny Graham.
Breast Cancer Res, 2020 Jul 22; 22(1). PMID: 32690069    Free PMC article.
Risk stratification in luminal-type breast cancer: Comparison of Ki-67 with EndoPredict test results.
Aurelia Noske, Sophie-Isabelle Anders, +6 authors, Evelyn Klein.
Breast, 2019 Dec 02; 49. PMID: 31786414    Free PMC article.
The healthcare value of the Magee Decision Algorithm™: use of Magee Equations™ and mitosis score to safely forgo molecular testing in breast cancer.
Rohit Bhargava, Beth Z Clark, +2 authors, David J Dabbs.
Mod Pathol, 2020 Mar 24; 33(8). PMID: 32203092    Free PMC article.
Currently favored sampling practices for tumor sequencing can produce optimal results in the clinical setting.
Lőrinc S Pongor, Gyöngyi Munkácsy, +2 authors, Balázs Győrffy.
Sci Rep, 2020 Sep 03; 10(1). PMID: 32873813    Free PMC article.
Examination of the Biomark assay as an alternative to Oncotype DX for defining chemotherapy benefit.
Jinkyoung Kim, Aeree Kim, Chungyeul Kim.
Oncol Lett, 2019 Jan 25; 17(2). PMID: 30675242    Free PMC article.
Tumor location of the central and nipple portion is associated with impaired survival for women with breast cancer.
Fei Ji, Wei-Kai Xiao, +10 authors, Kun Wang.
Cancer Manag Res, 2019 May 02; 11. PMID: 31040717    Free PMC article.
Clinical analysis of 21-gene recurrence score test in hormone receptor-positive early-stage breast cancer.
Lizhe Zhu, Nan Ma, +5 authors, Yu Ren.
Oncol Lett, 2019 Jun 13; 17(6). PMID: 31186766    Free PMC article.
Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer.
Mi Jeong Kwon, Jeong Eon Lee, +12 authors, Young Kee Shin.
Front Oncol, 2019 Aug 14; 9. PMID: 31404265    Free PMC article.
miRNA Expression Profiles in Luminal A Breast Cancer-Implications in Biology, Prognosis, and Prediction of Response to Hormonal Treatment.
Erik Kudela, Marek Samec, +8 authors, Kamil Biringer.
Int J Mol Sci, 2020 Oct 22; 21(20). PMID: 33080858    Free PMC article.
Comparison of breast cancer prognostic tests CanAssist Breast and Oncotype DX.
Aditya K Sengupta, Aparna Gunda, +4 authors, Manjiri M Bakre.
Cancer Med, 2020 Oct 08; 9(21). PMID: 33027559    Free PMC article.
Population-based screening for cancer: hope and hype.
Yiwey Shieh, Martin Eklund, +3 authors, Laura J Esserman.
Nat Rev Clin Oncol, 2016 Apr 14; 13(9). PMID: 27071351    Free PMC article.
Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective consecutive study.
Salvatore Pece, Davide Disalvatore, +8 authors, Pier Paolo Di Fiore.
EBioMedicine, 2019 Mar 09; 42. PMID: 30846393    Free PMC article.
Prediction of chemotherapy benefit by EndoPredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone.
Ivana Sestak, Miguel Martín, +12 authors, Michael Gnant.
Breast Cancer Res Treat, 2019 May 02; 176(2). PMID: 31041683    Free PMC article.
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