Pembrolizumab for the treatment of non-small-cell lung cancer

Edward B Garon ¹, Naiyer A Rizvi , Rina Hui , Natasha Leighl , Ani S Balmanoukian , Joseph Paul Eder , Amita Patnaik , Charu Aggarwal , Matthew Gubens , Leora Horn , Enric Carcereny , Myung-Ju Ahn , Enriqueta Felip , Jong-Seok Lee , Matthew D Hellmann , Omid Hamid , Jonathan W Goldman , Jean-Charles Soria , Marisa Dolled-Filhart , Ruth Z Rutledge , Jin Zhang , Jared K Lunceford , Reshma Rangwala , Gregory M Lubiniecki , Charlotte Roach , Kenneth Emancipator , Leena Gandhi , KEYNOTE-001 Investigators

Affiliations

¹ The authors' affiliations are listed in the Appendix.

PMID: 25891174
2361 citations

Abstract

Background: We assessed the efficacy and safety of programmed cell death 1 (PD-1) inhibition with pembrolizumab in patients with advanced non-small-cell lung cancer enrolled in a phase 1 study. We also sought to define and validate an expression level of the PD-1 ligand 1 (PD-L1) that is associated with the likelihood of clinical benefit.

Methods: We assigned 495 patients receiving pembrolizumab (at a dose of either 2 mg or 10 mg per kilogram of body weight every 3 weeks or 10 mg per kilogram every 2 weeks) to either a training group (182 patients) or a validation group (313 patients). We assessed PD-L1 expression in tumor samples using immunohistochemical analysis, with results reported as the percentage of neoplastic cells with staining for membranous PD-L1 (proportion score). Response was assessed every 9 weeks by central review.

Results: Common side effects that were attributed to pembrolizumab were fatigue, pruritus, and decreased appetite, with no clear difference according to dose or schedule. Among all the patients, the objective response rate was 19.4%, and the median duration of response was 12.5 months. The median duration of progression-free survival was 3.7 months, and the median duration of overall survival was 12.0 months. PD-L1 expression in at least 50% of tumor cells was selected as the cutoff from the training group. Among patients with a proportion score of at least 50% in the validation group, the response rate was 45.2%. Among all the patients with a proportion score of at least 50%, median progression-free survival was 6.3 months; median overall survival was not reached.

Conclusions: Pembrolizumab had an acceptable side-effect profile and showed antitumor activity in patients with advanced non-small-cell lung cancer. PD-L1 expression in at least 50% of tumor cells correlated with improved efficacy of pembrolizumab. (Funded by Merck; KEYNOTE-001 ClinicalTrials.gov number, NCT01295827.).

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Risk of pneumonitis in cancer patients treated with immune checkpoint inhibitors: a meta-analysis. Omar Abdel-Rahman, Mona Fouad. Ther Adv Respir Dis, 2016 Mar 06; 10(3). PMID: 26944362 Free PMC article.
PD-L1 Expression and Survival among Patients with Advanced Non-Small Cell Lung Cancer Treated with Chemotherapy. Steffen Filskov Sorensen, Wei Zhou, +7 authors, Henrik Hager. less Transl Oncol, 2016 Mar 08; 9(1). PMID: 26947883 Free PMC article.
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Jonathan E Rosenberg, Jean Hoffman-Censits, +28 authors, Robert Dreicer. less Lancet, 2016 Mar 10; 387(10031). PMID: 26952546 Free PMC article. Highly Cited.
Cellular and molecular biology of small cell lung cancer: an overview. Niki Karachaliou, Sara Pilotto, +3 authors, Rafael Rosell. less Transl Lung Cancer Res, 2016 Mar 10; 5(1). PMID: 26958489 Free PMC article. Review.
Immunotherapy in locally-advanced non-small cell lung cancer: releasing the brakes on consolidation? Abigail T Berman, Charles B Simone. Transl Lung Cancer Res, 2016 Mar 10; 5(1). PMID: 26958509 Free PMC article.
The Use of EGFR Tyrosine Kinase Inhibitors in EGFR Wild-Type Non-Small-Cell Lung Cancer. Thomas E Stinchcombe. Curr Treat Options Oncol, 2016 Mar 11; 17(4). PMID: 26961971 Review.
Vaccines for established cancer: overcoming the challenges posed by immune evasion. Sjoerd H van der Burg, Ramon Arens, +2 authors, Ferry Ossendorp, Thorbald van Hall, Cornelis J M Melief. less Nat Rev Cancer, 2016 Mar 12; 16(4). PMID: 26965076 Highly Cited. Review.
Personalized treatment of advanced non-small-cell lung cancer in routine clinical practice. Robert Pirker, Martin Filipits. Cancer Metastasis Rev, 2016 Mar 14; 35(1). PMID: 26970967 Free PMC article. Review.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok. Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780 Free PMC article. Highly Cited. Review.
Recognizing that the microbiome is part of the human immune system will advance treatment of both cancer and infections. Richard L Gallo, Thomas Hultsch, Lauge Farnaes. J Am Acad Dermatol, 2016 Mar 17; 74(4). PMID: 26979362 Free PMC article.
MicroRNAs provide a novel pathway toward combinatorial immune checkpoint blockade. Duane A Mitchell. Neuro Oncol, 2016 Mar 17; 18(5). PMID: 26980424 Free PMC article.
FDA Approval Summary: Nivolumab for the Treatment of Metastatic Non-Small Cell Lung Cancer With Progression On or After Platinum-Based Chemotherapy. Dickran Kazandjian, Daniel L Suzman, +5 authors, Richard Pazdur. less Oncologist, 2016 Mar 18; 21(5). PMID: 26984449 Free PMC article. Highly Cited.
Combining Epigenetic and Immunotherapy to Combat Cancer. Katherine B Chiappinelli, Cynthia A Zahnow, Nita Ahuja, Stephen B Baylin. Cancer Res, 2016 Mar 19; 76(7). PMID: 26988985 Free PMC article. Highly Cited. Review.
Multispectral Imaging of T and B Cells in Murine Spleen and Tumor. Zipei Feng, Shawn M Jensen, +4 authors, Bernard A Fox. less J Immunol, 2016 Mar 20; 196(9). PMID: 26994219 Free PMC article.
Phase 1 study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced solid tumors. Toshio Shimizu, Takashi Seto, +9 authors, Kazuhiko Nakagawa. less Invest New Drugs, 2016 Mar 24; 34(3). PMID: 27000274 Free PMC article.
Systemic Immunotherapy for the Treatment of Brain Metastases. Justine V Cohen, Harriet M Kluger. Front Oncol, 2016 Mar 26; 6. PMID: 27014624 Free PMC article. Review.
Rational selection of biomarker driven therapies for gynecologic cancers: The more we know, the more we know we don't know. Joyce Liu, Shannon N Westin. Gynecol Oncol, 2016 Mar 27; 141(1). PMID: 27016231 Free PMC article. Review.
FDA Approval Summary: Pembrolizumab for the Treatment of Patients With Metastatic Non-Small Cell Lung Cancer Whose Tumors Express Programmed Death-Ligand 1. Joohee Sul, Gideon M Blumenthal, +3 authors, Richard Pazdur. less Oncologist, 2016 Mar 31; 21(5). PMID: 27026676 Free PMC article. Highly Cited.
Into the Clinic With Nivolumab and Pembrolizumab. Catherine A Shu, Naiyer A Rizvi. Oncologist, 2016 Mar 31; 21(5). PMID: 27026678 Free PMC article.
Targeting persistent androgen receptor signaling in castration-resistant prostate cancer. Laura Graham, Michael T Schweizer. Med Oncol, 2016 Apr 05; 33(5). PMID: 27042852 Review.
The Face of the Next Generation in China. Chen Wang, Jinghong Li, Sinan Wu, Atul Malhotra. Am J Respir Crit Care Med, 2016 Apr 05; 193(10). PMID: 27043074 Free PMC article. Review.
Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor. V R Belum, B Benhuri, +8 authors, M E Lacouture. less Eur J Cancer, 2016 Apr 05; 60. PMID: 27043866 Free PMC article. Highly Cited. Systematic Review.
Clinical significance of PD-L1 and PD-L2 copy number gains in non-small-cell lung cancer. Yusuke Inoue, Katsuhiro Yoshimura, +12 authors, Haruhiko Sugimura. less Oncotarget, 2016 Apr 07; 7(22). PMID: 27050074 Free PMC article.
Clinical outcomes with pemetrexed-based systemic therapies in RET-rearranged lung cancers. A Drilon, I Bergagnini, +13 authors, M G Kris. less Ann Oncol, 2016 Apr 09; 27(7). PMID: 27056998 Free PMC article.
PD-1, PD-L1 and PD-L2 expression in mouse prostate cancer. Shijie Yang, Qiuyang Zhang, +2 authors, Sen Liu, Alun R Wang, Zongbing You. less Am J Clin Exp Urol, 2016 Apr 14; 4(1). PMID: 27069956 Free PMC article.
Epithelial-Mesenchymal Transition and Immune Evasion during Lung Cancer Progression: The Chicken or the Egg? Ila Datar, Kurt A Schalper. Clin Cancer Res, 2016 Apr 15; 22(14). PMID: 27076625 Free PMC article.
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Suzanne L Topalian, Janis M Taube, Robert A Anders, Drew M Pardoll. Nat Rev Cancer, 2016 Apr 16; 16(5). PMID: 27079802 Free PMC article. Highly Cited. Review.
Novel Treatment Strategies for Brain Metastases in Non-small-cell Lung Cancer. Nam Bui, Brian Woodward, Anna Johnson, Hatim Husain. Curr Treat Options Oncol, 2016 Apr 18; 17(5). PMID: 27085533 Review.
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma. Paul T Nghiem, Shailender Bhatia, +28 authors, Martin A Cheever. less N Engl J Med, 2016 Apr 20; 374(26). PMID: 27093365 Free PMC article. Highly Cited.
PD-L1 and Tumor Infiltrating Lymphocytes as Prognostic Markers in Resected NSCLC. Malaka Ameratunga, Khashayar Asadi, +6 authors, Thomas John. less PLoS One, 2016 Apr 23; 11(4). PMID: 27104612 Free PMC article.
Immune Checkpoint Therapies in Prostate Cancer. Sangeeta Goswami, Ana Aparicio, Sumit K Subudhi. Cancer J, 2016 Apr 26; 22(2). PMID: 27111907 Free PMC article. Review.
Systematic evaluation of pembrolizumab dosing in patients with advanced non-small-cell lung cancer. M Chatterjee, D C Turner, +20 authors, Ø Fløtten. less Ann Oncol, 2016 Apr 28; 27(7). PMID: 27117531 Free PMC article.
PD-L1 Expression in Lung Cancer. Hui Yu, Theresa A Boyle, +2 authors, Caicun Zhou, David L Rimm, Fred R Hirsch. less J Thorac Oncol, 2016 Apr 28; 11(7). PMID: 27117833 Free PMC article. Highly Cited. Review.
Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients. Amos Kirilovsky, Florence Marliot, +3 authors, Franck Pagès. less Int Immunol, 2016 Apr 29; 28(8). PMID: 27121213 Free PMC article. Highly Cited. Review.
Pembrolizumab in Patients With Advanced Triple-Negative Breast Cancer: Phase Ib KEYNOTE-012 Study. Rita Nanda, Laura Q M Chow, +9 authors, Laurence Buisseret. less J Clin Oncol, 2016 May 04; 34(21). PMID: 27138582 Free PMC article. Highly Cited.
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination. Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert. less Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885 Highly Cited. Review.
Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma. Megan L Ludwig, Andrew C Birkeland, +3 authors, J Chad Brenner. less Cancer Biol Med, 2016 May 05; 13(1). PMID: 27144065 Free PMC article.
Pembrolizumab in classical Hodgkin's lymphoma. Joseph Maly, Lapo Alinari. Eur J Haematol, 2016 May 06; 97(3). PMID: 27147112 Free PMC article. Review.
The Utility of Exercise Testing in Patients with Lung Cancer. Duc Ha, Peter J Mazzone, +2 authors, Andrew L Ries, Atul Malhotra, Mark Fuster. less J Thorac Oncol, 2016 May 10; 11(9). PMID: 27156441 Free PMC article. Review.
Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer. Janice M Mehnert, Anshuman Panda, +16 authors, Shridar Ganesan. less J Clin Invest, 2016 May 10; 126(6). PMID: 27159395 Free PMC article. Highly Cited.
The presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survival. Thomas K Kilvaer, Erna-Elise Paulsen, +6 authors, Tom Donnem. less Br J Cancer, 2016 May 12; 114(10). PMID: 27167450 Free PMC article.
PD-L1 polymorphism can predict clinical outcomes of non-small cell lung cancer patients treated with first-line paclitaxel-cisplatin chemotherapy. Shin Yup Lee, Deuk Kju Jung, +14 authors, Jae Yong Park. less Sci Rep, 2016 May 18; 6. PMID: 27181838 Free PMC article.
Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab. Benjamin Weide, Alexander Martens, +24 authors, Jedd D Wolchok. less Clin Cancer Res, 2016 Nov 01; 22(22). PMID: 27185375 Free PMC article. Highly Cited.
Nivolumab: A Review in Advanced Nonsquamous Non-Small Cell Lung Cancer. Gillian M Keating. Drugs, 2016 May 18; 76(9). PMID: 27189706 Review.
Expression of PD-1 on CD4+ T cells in peripheral blood associates with poor clinical outcome in non-small cell lung cancer. Hong Zheng, Xin Liu, +7 authors, Chandra P Belani. less Oncotarget, 2016 May 19; 7(35). PMID: 27191652 Free PMC article.
Checkpoint Inhibitors and Other Immune Therapies for Hodgkin and Non-Hodgkin Lymphoma. Eri Matsuki, Anas Younes. Curr Treat Options Oncol, 2016 May 20; 17(6). PMID: 27193488 Free PMC article. Review.
Precision Oncology Medicine: The Clinical Relevance of Patient-Specific Biomarkers Used to Optimize Cancer Treatment. Keith T Schmidt, Cindy H Chau, Douglas K Price, William D Figg. J Clin Pharmacol, 2016 May 21; 56(12). PMID: 27197880 Free PMC article. Review.
Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma. Saad Z Usmani, Brendan M Weiss, +15 authors, Hareth Nahi. less Blood, 2016 May 25; 128(1). PMID: 27216216 Free PMC article. Highly Cited.
Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma. Jakub Krejcik, Tineke Casneuf, +11 authors, A Kate Sasser. less Blood, 2016 May 26; 128(3). PMID: 27222480 Free PMC article. Highly Cited.
EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer: A Retrospective Analysis. Justin F Gainor, Alice T Shaw, +18 authors, Mari Mino-Kenudson. less Clin Cancer Res, 2016 May 27; 22(18). PMID: 27225694 Free PMC article. Highly Cited.
Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection? Lucia Festino, Gerardo Botti, +5 authors, Paolo A Ascierto. less Drugs, 2016 May 28; 76(9). PMID: 27229745 Highly Cited. Review.
Quantitative CD3 PET Imaging Predicts Tumor Growth Response to Anti-CTLA-4 Therapy. Benjamin M Larimer, Eric Wehrenberg-Klee, Alexander Caraballo, Umar Mahmood. J Nucl Med, 2016 May 28; 57(10). PMID: 27230929 Free PMC article.
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy. Weijie Ma, Barbara M Gilligan, Jianda Yuan, Tianhong Li. J Hematol Oncol, 2016 May 29; 9(1). PMID: 27234522 Free PMC article. Highly Cited. Review.
Checkpoint Inhibitors and Their Application in Breast Cancer. Davide Bedognetti, Cristina Maccalli, +2 authors, Barbara Seliger. less Breast Care (Basel), 2016 May 31; 11(2). PMID: 27239172 Free PMC article. Review.
Immunotherapy for head and neck cancer: latest developments and clinical potential. Joshua M Bauml, Roger B Cohen, Charu Aggarwal. Ther Adv Med Oncol, 2016 May 31; 8(3). PMID: 27239235 Free PMC article. Review.
Nintedanib in NSCLC: evidence to date and place in therapy. Giuseppe Bronte, Francesco Passiglia, +7 authors, Antonio Russo. less Ther Adv Med Oncol, 2016 May 31; 8(3). PMID: 27239237 Free PMC article. Review.
Genetic variations in immunomodulatory pathways to predict survival in patients with locoregional gastric cancer. Y Sunakawa, S Cao, +16 authors, H-J Lenz. less Pharmacogenomics J, 2016 Jun 01; 17(6). PMID: 27241062 Free PMC article.
Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+) ;LSL-Trp53(R172H/+) ;Pdx-1-Cre), Its Variants, and Their Application in Immuno-oncology Drug Discovery. Jae W Lee, Chad A Komar, +2 authors, Fee Bengsch, Kathleen Graham, Gregory L Beatty. less Curr Protoc Pharmacol, 2016 Jun 02; 73. PMID: 27248578 Free PMC article.
Metabolic regulation of immune responses: therapeutic opportunities. Nadine Assmann, David K Finlay. J Clin Invest, 2016 Jun 02; 126(6). PMID: 27249676 Free PMC article. Review.
Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma. Georgia J B McCaughan, Michael J Fulham, +5 authors, Vivek A Bhadri. less J Hematol Oncol, 2016 Jun 05; 9(1). PMID: 27259563 Free PMC article.
Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 - April 1, 2016, Tours, France. Guillaume Desoubeaux, Janice M Reichert, +11 authors, Nathalie Heuze-Vourc'h. less MAbs, 2016 Jun 09; 8(6). PMID: 27266390 Free PMC article.
Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial. Sarah B Goldberg, Scott N Gettinger, +18 authors, Harriet M Kluger. less Lancet Oncol, 2016 Jun 09; 17(7). PMID: 27267608 Free PMC article. Highly Cited.
Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma. Naoka Murakami, Thiago J Borges, Michifumi Yamashita, Leonardo V Riella. Clin Kidney J, 2016 Jun 09; 9(3). PMID: 27274826 Free PMC article.
Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside. R Bhome, H A Al Saihati, +5 authors, A H Mirnezami. less New Horiz Transl Med, 2016 Jun 09; 3(1). PMID: 27275004 Free PMC article.
What does the future hold for immunotherapy in cancer? Jarushka Naidoo, Bob T Li, Katja Schindler, David B Page. Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275490 Free PMC article.
TG4010 immunotherapy: a novel weapon against advanced non-small cell lung cancer? Ramon Andrade de Mello. Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275498 Free PMC article.
Clinical Trials in Non-Small Cell Lung Cancer with Biomarker-Driven Treatment Allocation: Ready or Not, Here We Come. Edward B Garon, Phillip A Abarca, +6 authors, Robert M Elashoff. less Crit Rev Oncog, 2015 Jan 01; 20(5-6). PMID: 27279233 Free PMC article. Review.
Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial. David Planchard, Benjamin Besse, +13 authors, Bruce E Johnson. less Lancet Oncol, 2016 Jun 11; 17(7). PMID: 27283860 Free PMC article. Highly Cited.
Stereotactic body radiotherapy for the pancreas: a critical review for the medical oncologist. Samuel K Kim, Cheng-Chia Wu, David P Horowitz. J Gastrointest Oncol, 2016 Jun 11; 7(3). PMID: 27284482 Free PMC article. Review.
Treatment with the nitric oxide synthase inhibitor L-NAME provides a survival advantage in a mouse model of Kras mutation-positive, non-small cell lung cancer. Nicole L K Pershing, Chi-Fu Jeffrey Yang, MengMeng Xu, Christopher M Counter. Oncotarget, 2016 Jun 11; 7(27). PMID: 27285753 Free PMC article.
Expression of PD-L1 in triple-negative breast cancer based on different immunohistochemical antibodies. Woo Young Sun, Yu Kyung Lee, Ja Seung Koo. J Transl Med, 2016 Jun 12; 14(1). PMID: 27286842 Free PMC article.
Immune Checkpoint Inhibitors in Older Adults. Rawad Elias, Joshua Morales, Yasser Rehman, Humera Khurshid. Curr Oncol Rep, 2016 Jun 12; 18(8). PMID: 27287329 Review.
Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for Extensive-Stage SCLC. Edurne Arriola, Matthew Wheater, +13 authors, Christian Ottensmeier. less J Thorac Oncol, 2016 Jun 15; 11(9). PMID: 27296105 Free PMC article.
Lymphocyte-activation gene-3, an important immune checkpoint in cancer. Yayi He, Christopher J Rivard, +5 authors, Fred R Hirsch. less Cancer Sci, 2016 Jun 15; 107(9). PMID: 27297395 Free PMC article. Highly Cited. Review.
Immune Checkpoint Inhibitors: Review and Management of Endocrine Adverse Events. Elisa González-Rodríguez, Delvys Rodríguez-Abreu, Spanish Group for Cancer Immuno-Biotherapy (GETICA). Oncologist, 2016 Jun 17; 21(7). PMID: 27306911 Free PMC article. Highly Cited. Review.
Inflammatory arthritis and sicca syndrome induced by nivolumab and ipilimumab. Laura C Cappelli, Anna Kristina Gutierrez, +10 authors, Clifton O Bingham. less Ann Rheum Dis, 2016 Jun 17; 76(1). PMID: 27307501 Free PMC article. Highly Cited.
Analysis of PD-L1, T-cell infiltrate and HLA expression in chondrosarcoma indicates potential for response to immunotherapy specifically in the dedifferentiated subtype. Marie Kostine, Arjen Hg Cleven, +3 authors, Judith V M G Bovée. less Mod Pathol, 2016 Jun 18; 29(9). PMID: 27312065
Profile of nivolumab in the treatment of metastatic squamous non-small-cell lung cancer. Yvonne Le Ang, Joline Sj Lim, Ross A Soo. Onco Targets Ther, 2016 Jun 18; 9. PMID: 27313464 Free PMC article. Review.
Deficient Mismatch Repair and the Role of Immunotherapy in Metastatic Colorectal Cancer. Dionisia Quiroga, H Kim Lyerly, Michael A Morse. Curr Treat Options Oncol, 2016 Jun 18; 17(8). PMID: 27315067 Review.
Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma. Ken Hatogai, Shigehisa Kitano, +8 authors, Atsushi Ochiai. less Oncotarget, 2016 Jun 21; 7(30). PMID: 27322149 Free PMC article.
Benefit-Risk Summary of Crizotinib for the Treatment of Patients With ROS1 Alteration-Positive, Metastatic Non-Small Cell Lung Cancer. Dickran Kazandjian, Gideon M Blumenthal, +4 authors, Richard Pazdur. less Oncologist, 2016 Jun 23; 21(8). PMID: 27328934 Free PMC article.
Acute rhabdomyolysis with severe polymyositis following ipilimumab-nivolumab treatment in a cancer patient with elevated anti-striated muscle antibody. Mehmet Asim Bilen, Sumit K Subudhi, +3 authors, Padmanee Sharma. less J Immunother Cancer, 2016 Jun 23; 4. PMID: 27330809 Free PMC article.
Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule. Howard L Kaufman, Lisa H Butterfield, +9 authors, Francesco M Marincola. less J Immunother Cancer, 2016 Jun 23; 4. PMID: 27330810 Free PMC article.
Development of a Companion Diagnostic PD-L1 Immunohistochemistry Assay for Pembrolizumab Therapy in Non-Small-cell Lung Cancer. Charlotte Roach, Nancy Zhang, +7 authors, Karina Kulangara. less Appl Immunohistochem Mol Morphol, 2016 Jun 23; 24(6). PMID: 27333219 Free PMC article. Highly Cited.
Integration of multiple "OMIC" biomarkers: A precision medicine strategy for lung cancer. Ana I Robles, Curtis C Harris. Lung Cancer, 2016 Jun 28; 107. PMID: 27344275 Free PMC article.
Immune checkpoint blockade in human cancer therapy: lung cancer and hematologic malignancies. Murali Janakiram, Vipul Pareek, +2 authors, Haiying Cheng, Deepa M Narasimhulu, Xingxing Zang. less Immunotherapy, 2016 Jun 29; 8(7). PMID: 27349980 Free PMC article. Review.
Programmed Death-1 Blockade With Pembrolizumab in Patients With Classical Hodgkin Lymphoma After Brentuximab Vedotin Failure. Philippe Armand, Margaret A Shipp, +8 authors, Craig H Moskowitz. less J Clin Oncol, 2016 Jun 30; 34(31). PMID: 27354476 Free PMC article. Highly Cited.
Nivolumab in Combination With Platinum-Based Doublet Chemotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer. Naiyer A Rizvi, Matthew D Hellmann, +13 authors, Scott Antonia. less J Clin Oncol, 2016 Jun 30; 34(25). PMID: 27354481 Free PMC article. Highly Cited.
The Future of Immunotherapy in the Treatment of Small Cell Lung Cancer. Leora Horn, Martin Reck, David R Spigel. Oncologist, 2016 Jun 30; 21(8). PMID: 27354668 Free PMC article. Review.
PD-L1 Expression in Human Placentas and Gestational Trophoblastic Diseases. Emanuela Veras, Robert J Kurman, Tian-Li Wang, Ie-Ming Shih. Int J Gynecol Pathol, 2016 Jul 01; 36(2). PMID: 27362903 Free PMC article.
Summary and Recommendations from the National Cancer Institute's Clinical Trials Planning Meeting on Novel Therapeutics for Non-Muscle Invasive Bladder Cancer. Seth P Lerner, Dean F Bajorin, +33 authors, Diane Zipursky Quale. less Bladder Cancer, 2016 Jul 05; 2(2). PMID: 27376138 Free PMC article.
Pembrolizumab: first experience with recurrent primary central nervous system (CNS) tumors. Deborah T Blumenthal, Michal Yalon, +6 authors, Felix Bokstein. less J Neurooncol, 2016 Jul 06; 129(3). PMID: 27377654
Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas. Natalie Vandeven, Paul Nghiem. Immunotherapy, 2016 Jul 07; 8(8). PMID: 27381685 Free PMC article. Review.
Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations. Jun Wang, Baocheng Wang, Huili Chu, Yunfeng Yao. Onco Targets Ther, 2016 Jul 07; 9. PMID: 27382309 Free PMC article. Review.
The role of pembrolizumab in the treatment of advanced non-small cell lung cancer. Giuseppe Santabarbara, Paolo Maione, +2 authors, Antonio Rossi, Giovanni Palazzolo, Cesare Gridelli. less Ann Transl Med, 2016 Jul 08; 4(11). PMID: 27386489 Free PMC article. Review.
Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas. Andreas H Scheel, Manfred Dietel, +12 authors, Reinhard Buettner. less Mod Pathol, 2016 Jul 09; 29(10). PMID: 27389313 Highly Cited.
Battling regional (stage III) lung cancer: bumpy road of a cancer survivor in the immunotherapy age. Zhonglin Hao, Paul Biddinger, Carsten Schroeder, Khurram Tariq. BMJ Case Rep, 2016 Jul 09; 2016. PMID: 27389724 Free PMC article.
Pembrolizumab (Keytruda). Gerry Kwok, Thomas C C Yau, +2 authors, Joanne W Chiu, Eric Tse, Yok-Lam Kwong. less Hum Vaccin Immunother, 2016 Jul 12; 12(11). PMID: 27398650 Free PMC article. Review.
Clinician Perspectives on Current Issues in Lung Cancer Drug Development. Saiama N Waqar, Philip D Bonomi, +17 authors, Gideon M Blumenthal. less J Thorac Oncol, 2016 Jul 13; 11(9). PMID: 27401214 Free PMC article. Review.
Clinical and Histologic Features of Lichenoid Mucocutaneous Eruptions Due to Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Immunotherapy. Veronica J Shi, Nemanja Rodic, +5 authors, Jennifer N Choi. less JAMA Dermatol, 2016 Jul 14; 152(10). PMID: 27411054 Free PMC article.
Mechanisms of immune evasion and current status of checkpoint inhibitors in non-small cell lung cancer. Angel Qin, David G Coffey, Edus H Warren, Nithya Ramnath. Cancer Med, 2016 Jul 16; 5(9). PMID: 27416962 Free PMC article. Review.
Early evidence of anti-PD-1 activity in enzalutamide-resistant prostate cancer. Julie N Graff, Joshi J Alumkal, +8 authors, Tomasz M Beer. less Oncotarget, 2016 Jul 19; 7(33). PMID: 27429197 Free PMC article. Highly Cited.
Metastatic melanoma and immunotherapy. Benjamin Herzberg, David E Fisher. Clin Immunol, 2016 Jul 20; 172. PMID: 27430520 Free PMC article. Review.
Targeted therapies and immunotherapy in non-small-cell lung cancer. D Cortinovis, M Abbate, +2 authors, P Bidoli, S Capici, S Canova. less Ecancermedicalscience, 2016 Jul 20; 10. PMID: 27433281 Free PMC article. Review.
Tumor infiltrating lymphocytes and PD-L1 expression in brain metastases of small cell lung cancer (SCLC). Anna Sophie Berghoff, Gerda Ricken, +6 authors, Matthias Preusser. less J Neurooncol, 2016 Oct 21; 130(1). PMID: 27436101
Cancer immunotherapy trials: leading a paradigm shift in drug development. Leisha A Emens, Lisa H Butterfield, +2 authors, Howard L Kaufman. less J Immunother Cancer, 2016 Jul 21; 4. PMID: 27437105 Free PMC article.
Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma. Lik Hang Lee, Marcela S Cavalcanti, +12 authors, Jinru Shia. less Mod Pathol, 2016 Oct 28; 29(11). PMID: 27443512 Free PMC article. Highly Cited.
Proteomic-Based Approaches for the Study of Cytokines in Lung Cancer. Ángela Marrugal, Laura Ojeda, +2 authors, Luis Paz-Ares, Sonia Molina-Pinelo, Irene Ferrer. less Dis Markers, 2016 Jul 23; 2016. PMID: 27445423 Free PMC article. Review.
PD-L1 expression is associated with advanced non-small cell lung cancer. Zhiquan Chen, Jiandong Mei, +6 authors, Liu Zhang. less Oncol Lett, 2016 Jul 23; 12(2). PMID: 27446371 Free PMC article.
Expression of PD-1, PD-L1 and PD-L2 is associated with differentiation status and histological type of endometrial cancer. Zhongfu Mo, Jing Liu, +7 authors, Zongbing You. less Oncol Lett, 2016 Jul 23; 12(2). PMID: 27446374 Free PMC article.
High-Resolution PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers. Michael Hettich, Friederike Braun, +2 authors, Gabriele Niedermann. less Theranostics, 2016 Jul 23; 6(10). PMID: 27446497 Free PMC article. Highly Cited.
PD-1 blockade enhances the vaccination-induced immune response in glioma. Joseph P Antonios, Horacio Soto, +9 authors, Robert M Prins. less JCI Insight, 2016 Jul 28; 1(10). PMID: 27453950 Free PMC article. Highly Cited.
Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma. Pratistha Koirala, Michael E Roth, +8 authors, Richard Gorlick. less Sci Rep, 2016 Jul 28; 6. PMID: 27456063 Free PMC article. Highly Cited.
Chemotherapy remains an essential element of personalized care for persons with lung cancers. M D Hellmann, B T Li, J E Chaft, M G Kris. Ann Oncol, 2016 Jul 28; 27(10). PMID: 27456296 Free PMC article. Review.
Programmed cell death ligand-1 (PD-L1) expression by immunohistochemistry: could it be predictive and/or prognostic in non-small cell lung cancer? Mari Mino-Kenudson. Cancer Biol Med, 2016 Jul 28; 13(2). PMID: 27458525 Free PMC article.
Immuno-oncology combinations: raising the tail of the survival curve. Samuel J Harris, Jessica Brown, Juanita Lopez, Timothy A Yap. Cancer Biol Med, 2016 Jul 28; 13(2). PMID: 27458526 Free PMC article.
An update on clinical oncology for the non-oncologist. Rafael Aliosha Kaliks. Einstein (Sao Paulo), 2016 Jul 28; 14(2). PMID: 27462901 Free PMC article. Review.
Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion. Eunseon Ahn, Ben Youngblood, +3 authors, Rafi Ahmed. less J Virol, 2016 Jul 29; 90(19). PMID: 27466420 Free PMC article.
PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations. Andreas H Scheel, Sascha Ansén, +14 authors, Jürgen Wolf. less Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467949 Free PMC article.
Molecular Imaging of Immunotherapy Targets in Cancer. Emily B Ehlerding, Christopher G England, Douglas G McNeel, Weibo Cai. J Nucl Med, 2016 Jul 30; 57(10). PMID: 27469363 Free PMC article. Review.
Reliable Entity Subtyping in Non-small Cell Lung Cancer by Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry on Formalin-fixed Paraffin-embedded Tissue Specimens. Mark Kriegsmann, Rita Casadonte, +7 authors, Wilko Weichert. less Mol Cell Proteomics, 2016 Jul 31; 15(10). PMID: 27473201 Free PMC article.
The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer. Vassiliki Papadimitrakopoulou, J Jack Lee, +25 authors, Roy S Herbst. less J Clin Oncol, 2016 Aug 03; 34(30). PMID: 27480147 Free PMC article. Highly Cited.
Immune Checkpoint Blockade: A New Era for Non-Small Cell Lung Cancer. Raffaele Califano, Keith Kerr, +4 authors, Antonio Rossi. less Curr Oncol Rep, 2016 Aug 04; 18(9). PMID: 27484062 Review.
Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy. Benedetto Farsaci, Renee N Donahue, +9 authors, Jeffrey Schlom. less Cancer Immunol Res, 2016 Aug 04; 4(9). PMID: 27485137 Free PMC article.
Treatment outcome of PD-1 immune checkpoint inhibitor in Asian metastatic melanoma patients: correlative analysis with PD-L1 immunohistochemistry. Jinhyun Cho, Soomin Ahn, +4 authors, Jeeyun Lee. less Invest New Drugs, 2016 Aug 06; 34(6). PMID: 27491654
[Pathology of lung cancer]. D Theegarten, T Hager. Radiologe, 2016 Aug 09; 56(9). PMID: 27495784 Review.
Dramatic response to anti-PD-1 therapy in a patient of squamous cell carcinoma of thymus with multiple lung metastases. Yan Yang, Liren Ding, Pingli Wang. J Thorac Dis, 2016 Aug 09; 8(7). PMID: 27499991 Free PMC article.
[Predictive PD-L1 immunohistochemistry for non-small cell lung cancer : Current state of the art and experiences of the first German harmonization study]. A H Scheel, M Dietel, +12 authors, R Büttner. less Pathologe, 2016 Oct 28; 37(6). PMID: 27510417 Review.
Regulatory circuits of T cell function in cancer. Daniel E Speiser, Ping-Chih Ho, Grégory Verdeil. Nat Rev Immunol, 2016 Aug 17; 16(10). PMID: 27526640 Highly Cited. Review.
It's TIME for a biomarker-driven approach to cancer immunotherapy. Leisha A Emens. J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532018 Free PMC article.
PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction? Claud Grigg, Naiyer A Rizvi. J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532023 Free PMC article. Highly Cited. Review.
Clinical outcomes in metastatic uveal melanoma treated with PD-1 and PD-L1 antibodies. Alain P Algazi, Katy K Tsai, +13 authors, Ryan J Sullivan. less Cancer, 2016 Oct 21; 122(21). PMID: 27533448 Free PMC article. Highly Cited.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer. Benjamin Herzberg, Meghan J Campo, Justin F Gainor. Oncologist, 2016 Aug 19; 22(1). PMID: 27534574 Free PMC article. Review.
PD-1 Inhibitor-Related Pneumonitis in Advanced Cancer Patients: Radiographic Patterns and Clinical Course. Mizuki Nishino, Nikhil H Ramaiya, +7 authors, F Stephen Hodi. less Clin Cancer Res, 2016 Aug 19; 22(24). PMID: 27535979 Free PMC article. Highly Cited.
New targeted treatments for non-small-cell lung cancer - role of nivolumab. Giulia Zago, Mirte Muller, Michel van den Heuvel, Paul Baas. Biologics, 2016 Aug 19; 10. PMID: 27536062 Free PMC article. Review.
A Quantitative Comparison of Antibodies to Programmed Cell Death 1 Ligand 1. Patricia Gaule, James W Smithy, +7 authors, David L Rimm. less JAMA Oncol, 2016 Aug 20; 3(2). PMID: 27541827 Free PMC article. Highly Cited.
HHLA2, a New Immune Checkpoint Member of the B7 Family, Is Widely Expressed in Human Lung Cancer and Associated with EGFR Mutational Status. Haiying Cheng, Murali Janakiram, +7 authors, Xingxing Zang. less Clin Cancer Res, 2016 Aug 25; 23(3). PMID: 27553831 Free PMC article.
Utilization of ancillary studies in the cytologic diagnosis of respiratory lesions: The papanicolaou society of cytopathology consensus recommendations for respiratory cytology. Lester J Layfield, Sinchita Roy-Chowdhuri, +9 authors, Paul A VanderLaan. less Diagn Cytopathol, 2016 Aug 27; 44(12). PMID: 27561242 Free PMC article.
PD-L1 expression in basaloid squamous cell lung carcinoma: Relationship to PD-1+ and CD8+ tumor-infiltrating T cells and outcome. Marius Ilie, Alexander T Falk, +12 authors, Paul Hofman. less Mod Pathol, 2016 Aug 27; 29(12). PMID: 27562497
Adding checkpoint inhibitors to tyrosine kinase inhibitors targeting EGFR/ALK in non-small cell lung cancer: a new therapeutic strategy. Samer Tabchi, Hampig Raphael Kourie, Joseph Kattan. Invest New Drugs, 2016 Aug 27; 34(6). PMID: 27562868
DNA damage, tumor mutational load and their impact on immune responses against cancer. Michalis Liontos, Ioannis Anastasiou, Aristotelis Bamias, Meletios-Athanasios Dimopoulos. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563651 Free PMC article. Review.
The European Organization for Research and Treatment of Cancer perspective on designing clinical trials with immune therapeutics. Jessica Menis, Saskia Litière, Konstantinos Tryfonidis, Vassilis Golfinopoulos. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563654 Free PMC article. Review.
Immunotherapy in non-small cell lung cancer: the clinical impact of immune response and targeting. Giannis Mountzios, Helena Linardou, Paris Kosmidis. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563655 Free PMC article. Review.
Toxicity management of immunotherapy for patients with metastatic melanoma. Helena Linardou, Helen Gogas. Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563659 Free PMC article. Review.
Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer. Kazuhiko Shien, Vassiliki A Papadimitrakopoulou, Ignacio I Wistuba. Lung Cancer, 2016 Aug 28; 99. PMID: 27565919 Free PMC article. Review.
Incidence of Thyroid-Related Adverse Events in Melanoma Patients Treated With Pembrolizumab. Jeroen de Filette, Yanina Jansen, +4 authors, Bert Bravenboer. less J Clin Endocrinol Metab, 2016 Nov 05; 101(11). PMID: 27571185 Free PMC article. Highly Cited.
Crizotinib resistance: implications for therapeutic strategies. I Dagogo-Jack, A T Shaw. Ann Oncol, 2016 Aug 31; 27 Suppl 3. PMID: 27573756 Free PMC article. Review.
Immune checkpoint inhibitors: the new frontier in non-small-cell lung cancer treatment. Hazem El-Osta, Kamran Shahid, Glenn M Mills, Prakash Peddi. Onco Targets Ther, 2016 Aug 31; 9. PMID: 27574451 Free PMC article. Review.
Investigation of PD-L1 Biomarker Testing Methods for PD-1 Axis Inhibition in Non-squamous Non-small Cell Lung Cancer. Brandon S Sheffield, Regan Fulton, +15 authors, Diana N Ionescu. less J Histochem Cytochem, 2016 Sep 04; 64(10). PMID: 27591097 Free PMC article.
The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Richard Beatson, Virginia Tajadura-Ortega, +9 authors, Joy M Burchell. less Nat Immunol, 2016 Oct 21; 17(11). PMID: 27595232 Free PMC article. Highly Cited.
Monitoring of the Immune Dysfunction in Cancer Patients. Saskia J A M Santegoets, Marij J P Welters, Sjoerd H van der Burg. Vaccines (Basel), 2016 Sep 07; 4(3). PMID: 27598210 Free PMC article. Review.
Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA. Jeffrey C Thompson, Stephanie S Yee, +19 authors, Erica L Carpenter. less Clin Cancer Res, 2016 Sep 08; 22(23). PMID: 27601595 Free PMC article. Highly Cited.
Rapid bone repair in a patient with lung cancer metastases to the spine using a novel herbal medicine: A case report. Rong Pu, Qianhong Zhao, +5 authors, Xianyong Li. less Oncol Lett, 2016 Sep 08; 12(3). PMID: 27602132 Free PMC article.
[Immunotherapeutic studies of head and neck tumors : Highlights of the 2016 ASCO Annual Meeting]. C-J Busch, S Laban, R Knecht, T K Hoffmann. HNO, 2016 Sep 09; 64(10). PMID: 27604282 Review.
Immunotherapy in human colorectal cancer: Challenges and prospective. Xuan Sun, Jian Suo, Jun Yan. World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605872 Free PMC article. Review.
Advances in lung cancer with a focus on ATS 2016 updates. Jinghong Li, Mark M Fuster. J Thorac Dis, 2016 Sep 09; 8(Suppl 7). PMID: 27606096 Free PMC article.
Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy. Rikke B Holmgaard, Alexandra Brachfeld, +7 authors, Taha Merghoub. less Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622016 Free PMC article.
PD-L1 expression as a predictive biomarker for cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma. Chang-Long Chen, Qiu-Zhong Pan, +12 authors, Jian-Chuan Xia. less Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622026 Free PMC article.
Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop. Roch Houot, Philippe Gaulard, +18 authors, Daniel Olive. less Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622041 Free PMC article.
Carcinogenesis of renal cell carcinoma reflected in HLA ligands: A novel approach for synergistic peptide vaccination design. Martin G Klatt, Daniel J Kowalewski, +5 authors, Stefan Stevanović. less Oncoimmunology, 2016 Sep 14; 5(8). PMID: 27622074 Free PMC article.
[Immunotherapy for HNSCC : Quo vadis?]. J Döscher, C-J Busch, P J Schuler, S Laban. HNO, 2016 Sep 15; 64(10). PMID: 27624904 Review.
Update in Lung Cancer 2015. Avrum Spira, Balazs Halmos, Charles A Powell. Am J Respir Crit Care Med, 2016 Sep 16; 194(6). PMID: 27628077 Free PMC article.
Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients. Akihito Kawazoe, Takeshi Kuwata, +7 authors, Atsushi Ochiai. less Gastric Cancer, 2016 Sep 16; 20(3). PMID: 27629881 Highly Cited.
PD-L1 Expression by Two Complementary Diagnostic Assays and mRNA In Situ Hybridization in Small Cell Lung Cancer. Hui Yu, Cory Batenchuk, +23 authors, Fred R Hirsch. less J Thorac Oncol, 2016 Oct 25; 12(1). PMID: 27639678 Free PMC article.
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy. Jarushka Naidoo, Xuan Wang, +26 authors, Matthew D Hellmann. less J Clin Oncol, 2016 Sep 21; 35(7). PMID: 27646942 Free PMC article. Highly Cited.
Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort. Laura Q M Chow, Robert Haddad, +19 authors, Tanguy Y Seiwert. less J Clin Oncol, 2016 Sep 21; 34(32). PMID: 27646946 Free PMC article. Highly Cited.
Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors. Yu Mei, Wenya Linda Bi, +11 authors, Ian F Dunn. less Oncotarget, 2016 Sep 23; 7(47). PMID: 27655724 Free PMC article.
Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients. Archana Anantharaman, Terence Friedlander, +14 authors, Pamela L Paris. less BMC Cancer, 2016 Sep 24; 16(1). PMID: 27658492 Free PMC article.
Safety and efficacy of pembrolizumab in a patient with advanced melanoma on haemodialysis. Rubens Chang, Keisuke Shirai. BMJ Case Rep, 2016 Sep 24; 2016. PMID: 27659911 Free PMC article.
Systemic inflammation is associated with the density of immune cells in the tumor microenvironment of gastric cancer. Yeonjoo Choi, Jin Won Kim, +7 authors, Hyung-Ho Kim. less Gastric Cancer, 2016 Sep 26; 20(4). PMID: 27665104
The efficacy and safety of anti-PD-1/PD-L1 antibodies for treatment of advanced or refractory cancers: a meta-analysis. Tengfei Zhang, Jing Xie, +13 authors, Yi Zhang. less Oncotarget, 2016 Sep 30; 7(45). PMID: 27683031 Free PMC article.
Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix. Damian T Rieke, Sebastian Ochsenreither, +4 authors, Ulrich Keilholz. less Oncotarget, 2016 Sep 30; 7(46). PMID: 27683114 Free PMC article.
Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies. Charli Dominguez, Kwong-Yok Tsang, Claudia Palena. Cell Death Dis, 2016 Sep 30; 7(9). PMID: 27685624 Free PMC article.
Trends and advances in tumor immunology and lung cancer immunotherapy. Mohanad Aldarouish, Cailian Wang. J Exp Clin Cancer Res, 2016 Oct 01; 35(1). PMID: 27686848 Free PMC article. Review.
Catching up with solid tumor oncology: what is the evidence for a prognostic role of programmed cell death-ligand 1/programmed cell death-1 expression in B-cell lymphomas? Fabienne McClanahan, Thomas G Sharp, John G Gribben. Haematologica, 2016 Oct 04; 101(10). PMID: 27694502 Free PMC article. Review.
NCCN Guidelines Insights: Bladder Cancer, Version 2.2016. Peter E Clark, Philippe E Spiess, +33 authors, Courtney Smith. less J Natl Compr Canc Netw, 2016 Oct 05; 14(10). PMID: 27697976 Free PMC article.
Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes. Patrick H Lizotte, Elena V Ivanova, +23 authors, Kwok-Kin Wong. less JCI Insight, 2016 Oct 05; 1(14). PMID: 27699239 Free PMC article. Highly Cited.
Spotlight on pembrolizumab in non-small cell lung cancer: the evidence to date. Pankit Vachhani, Hongbin Chen. Onco Targets Ther, 2016 Oct 08; 9. PMID: 27713639 Free PMC article. Review.
Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody. Tadanobu Nagaya, Yuko Nakamura, +5 authors, Hisataka Kobayashi. less Oncotarget, 2016 Oct 08; 8(5). PMID: 27716622 Free PMC article.
Development of a programmed cell death ligand-1 immunohistochemical assay validated for analysis of non-small cell lung cancer and head and neck squamous cell carcinoma. Marlon C Rebelatto, Anita Midha, +8 authors, Jill Walker. less Diagn Pathol, 2016 Oct 09; 11(1). PMID: 27717372 Free PMC article. Highly Cited.
Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis. Xi Zhang, Yuge Ran, +2 authors, Kunjie Wang, Yuanxue Zhu, Jinghua Li. less Drug Des Devel Ther, 2016 Oct 13; 10. PMID: 27729774 Free PMC article.
Programmed death-ligand 1 expression in gastric adenocarcinoma is a poor prognostic factor in a high CD8+ tumor infiltrating lymphocytes group. Hyeyoon Chang, Woon Yong Jung, +5 authors, Baek-Hui Kim. less Oncotarget, 2016 Oct 16; 7(49). PMID: 27741514 Free PMC article.
Squamous cell carcinoma associated with chronic graft versus host disease-like/lichen planus-like lesion of the oral cavity in a patient managed for metastatic melanoma with a PD-1 inhibitor pembrolizumab. Adepitan A Owosho, Joseph Randazzo, +4 authors, SaeHee K Yom. less Oral Oncol, 2016 Oct 17; 63. PMID: 27743938 Free PMC article.
Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study. Corey J Langer, Shirish M Gadgeel, +17 authors, KEYNOTE-021 investigators. less Lancet Oncol, 2016 Oct 18; 17(11). PMID: 27745820 Free PMC article. Highly Cited.
Biomarkers for immune therapy in colorectal cancer: mismatch-repair deficiency and others. Manojkumar Bupathi, Christina Wu. J Gastrointest Oncol, 2016 Oct 18; 7(5). PMID: 27747085 Free PMC article. Review.
The promise of PD-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. PD-L1. Zhaohui Jin, Harry H Yoon. J Gastrointest Oncol, 2016 Oct 18; 7(5). PMID: 27747091 Free PMC article. Review.
Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data. Gustavo Dix Junqueira Pinto, Luciano de Souza Viana, Cristovam Scapulatempo Neto, Sérgio Vicente Serrano. J Immunol Res, 2016 Oct 18; 2016. PMID: 27747247 Free PMC article.
A phase I trial of panobinostat (LBH589) in patients with metastatic melanoma. Nageatte Ibrahim, Elizabeth I Buchbinder, +7 authors, F Stephen Hodi. less Cancer Med, 2016 Oct 18; 5(11). PMID: 27748045 Free PMC article.
Trial Watch: Immunotherapy plus radiation therapy for oncological indications. Erika Vacchelli, Norma Bloy, +13 authors, Lorenzo Galluzzi. less Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757313 Free PMC article. Review.
[Progress in Immunotherapy for Squamous Non-small Cell Lung Cancer]. Shouzheng Wang, Junling Li. Zhongguo Fei Ai Za Zhi, 2016 Oct 21; 19(10). PMID: 27760599 Free PMC article. Review.
Correlation between anti-PD-L1 tumor concentrations and tumor-specific and nonspecific biomarkers in a melanoma mouse model. Ana M Contreras-Sandoval, María Merino, +3 authors, María J Garrido. less Oncotarget, 2016 Oct 21; 7(47). PMID: 27764774 Free PMC article.
From 2000 to 2016: Which Second-Line Treatment in Advanced Non-Small Cell Lung Cancer? Ettore D'Argento, Sabrina Rossi, +4 authors, Carlo Barone. less Curr Treat Options Oncol, 2016 Oct 22; 17(12). PMID: 27766545 Review.
Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report. Taofeek K Owonikoko, Mukesh Kumar, +10 authors, Suresh S Ramalingam. less Cancer Immunol Immunother, 2016 Oct 25; 66(1). PMID: 27771741 Free PMC article.
Multiplatform-based molecular subtypes of non-small-cell lung cancer. F Chen, Y Zhang, +9 authors, C J Creighton. less Oncogene, 2016 Oct 25; 36(10). PMID: 27775076 Free PMC article.
Safety and efficacy of anti-PD-1 in patients with baseline cardiac, renal, or hepatic dysfunction. Bridgette A Kanz, Megan H Pollack, +8 authors, Douglas B Johnson. less J Immunother Cancer, 2016 Oct 26; 4. PMID: 27777770 Free PMC article.
Soluble programmed death-ligand 1 (sPDL1) and neutrophil-to-lymphocyte ratio (NLR) predicts survival in advanced biliary tract cancer patients treated with palliative chemotherapy. Hyerim Ha, Ah-Rong Nam, +8 authors, Do-Youn Oh. less Oncotarget, 2016 Oct 27; 7(47). PMID: 27780932 Free PMC article.
Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy. Ju Yeon Lee, Hyun Tae Lee, +11 authors, Yong-Seok Heo. less Nat Commun, 2016 Nov 01; 7. PMID: 27796306 Free PMC article. Highly Cited.
Lung Cancer Subtypes Generate Unique Immune Responses. Stephanie E Busch, Mark L Hanke, +3 authors, A McGarry Houghton. less J Immunol, 2016 Nov 02; 197(11). PMID: 27799309 Free PMC article.
Checkpoint inhibitors in lung cancer: latest developments and clinical potential. Gustavo Schvartsman, Renata Ferrarotto, Erminia Massarelli. Ther Adv Med Oncol, 2016 Nov 02; 8(6). PMID: 27800034 Free PMC article. Review.
Recent advances in understanding antitumor immunity. Rodrigo Ramella Munhoz, Michael Andrew Postow. F1000Res, 2016 Nov 03; 5. PMID: 27803807 Free PMC article. Review.
PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Aaron Goodman, Sandip P Patel, Razelle Kurzrock. Nat Rev Clin Oncol, 2016 Nov 03; 14(4). PMID: 27805626 Highly Cited. Review.
Cross-talk between microbiota and immune fitness to steer and control response to anti PD-1/PDL-1 treatment. Andrea Botticelli, Ilaria Zizzari, +6 authors, Paolo Marchetti. less Oncotarget, 2016 Nov 03; 8(5). PMID: 27806346 Free PMC article. Review.
Programmed Death-Ligand 1 Expression, Microsatellite Instability, Epstein-Barr Virus, and Human Papillomavirus in Nasopharyngeal Carcinomas of Patients from the Philippines. Ann Margaret V Chang, Simion I Chiosea, +2 authors, Alexey Altman, Hester A Pagdanganan, Changqing Ma. less Head Neck Pathol, 2016 Nov 04; 11(2). PMID: 27807760 Free PMC article.
Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies. Shuguang Tan, Danqing Chen, +9 authors, George F Gao. less Protein Cell, 2016 Nov 07; 7(12). PMID: 27815822 Free PMC article. Review.
Impact of clinical parameters and systemic inflammatory status on epidermal growth factor receptor-mutant non-small cell lung cancer patients readministration with epidermal growth factor receptor tyrosine kinase inhibitors. Yu-Mu Chen, Chien-Hao Lai, +15 authors, Meng-Chih Lin. less BMC Cancer, 2016 Nov 09; 16(1). PMID: 27821111 Free PMC article.
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors. Wei Xue, Victoria A Brentville, +4 authors, Lindy G Durrant. less Oncotarget, 2016 Nov 09; 7(50). PMID: 27825115 Free PMC article.
Pembrolizumab as first-line treatment for non-small cell lung cancer-a game changer? Wolfram C M Dempke, Klaus Fenchel. Transl Lung Cancer Res, 2016 Nov 09; 5(5). PMID: 27826536 Free PMC article.
Development of Papulopustular Rosacea during Nivolumab Therapy for Metastatic Cancer. Emilie Bousquet, Allison Zarbo, +4 authors, Vincent Sibaud. less Acta Derm Venereol, 2016 Nov 09; 97(4). PMID: 27826614 Free PMC article.
Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity. Tony T Jiang, Tijana Martinov, +4 authors, Sing Sing Way. less Cell Rep, 2016 Nov 10; 17(7). PMID: 27829150 Free PMC article.
Targeted therapies for the treatment of non-small-cell lung cancer: Monoclonal antibodies and biological inhibitors. Ana P S Silva, Priscila V Coelho, Maristella Anazetti, Patricia U Simioni. Hum Vaccin Immunother, 2016 Nov 11; 13(4). PMID: 27831000 Free PMC article. Review.
Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer. Jamaal A Rehman, Gang Han, +6 authors, David L Rimm. less Mod Pathol, 2016 Nov 12; 30(3). PMID: 27834350 Free PMC article. Highly Cited.
Gene-expression profiling to predict responsiveness to immunotherapy. N B Jamieson, A V Maker. Cancer Gene Ther, 2016 Nov 12; 24(3). PMID: 27834354 Free PMC article. Review.
Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy. Maarten Swart, Inge Verbrugge, Joost B Beltman. Front Oncol, 2016 Nov 17; 6. PMID: 27847783 Free PMC article. Highly Cited. Review.
Toxicity profile of approved anti-PD-1 monoclonal antibodies in solid tumors: a systematic review and meta-analysis of randomized clinical trials. Ricardo Costa, Benedito A Carneiro, +6 authors, Francis J Giles. less Oncotarget, 2016 Nov 17; 8(5). PMID: 27852042 Free PMC article. Systematic Review.
Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma. Kent W Mouw, James M Cleary, +16 authors, Alan D D'Andrea. less Clin Cancer Res, 2016 Nov 18; 23(12). PMID: 27852700 Free PMC article.
Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapy. Yayan T Sundara, Marie Kostine, +3 authors, Anne-Marie Cleton-Jansen. less Cancer Immunol Immunother, 2016 Nov 18; 66(1). PMID: 27853827 Free PMC article.
Using Model-Based "Learn and Confirm" to Reveal the Pharmacokinetics-Pharmacodynamics Relationship of Pembrolizumab in the KEYNOTE-001 Trial. J Elassaiss-Schaap, S Rossenu, +4 authors, D P de Alwis. less CPT Pharmacometrics Syst Pharmacol, 2016 Nov 20; 6(1). PMID: 27863143 Free PMC article.
Programmed Death-Ligand 1 Expression and Response to the Anti-Programmed Death 1 Antibody Pembrolizumab in Melanoma. Adil I Daud, Jedd D Wolchok, +21 authors, Omid Hamid. less J Clin Oncol, 2016 Nov 20; 34(34). PMID: 27863197 Free PMC article. Highly Cited.
Resistance to anticancer immunity in cancer patients: potential strategies to reverse resistance. B Bonavida, S Chouaib. Ann Oncol, 2016 Nov 20; 28(3). PMID: 27864216 Free PMC article. Review.
Immunotherapy and lung cancer: from therapeutic cancer vaccination to novel approaches. Valentina Mazza, Federico Cappuzzo. J Thorac Dis, 2016 Nov 22; 8(10). PMID: 27867624 Free PMC article.
Next generation predictive biomarkers for immune checkpoint inhibition. Yulian Khagi, Razelle Kurzrock, Sandip Pravin Patel. Cancer Metastasis Rev, 2016 Nov 23; 36(1). PMID: 27873079 Free PMC article. Review.
Glucocorticoids did not reverse type 1 diabetes mellitus secondary to pembrolizumab in a patient with metastatic melanoma. Jasna Aleksova, Peter K H Lau, Georgia Soldatos, Grant McArthur. BMJ Case Rep, 2016 Nov 25; 2016. PMID: 27881588 Free PMC article.
Advances in Cancer Immunotherapy in Solid Tumors. Smitha Menon, Sarah Shin, Grace Dy. Cancers (Basel), 2016 Nov 26; 8(12). PMID: 27886124 Free PMC article. Highly Cited. Review.
Validation of biomarkers to predict response to immunotherapy in cancer: Volume II - clinical validation and regulatory considerations. Kevin K Dobbin, Alessandra Cesano, +10 authors, Magdalena Thurin. less J Immunother Cancer, 2016 Nov 29; 4. PMID: 27891226 Free PMC article. Review.
Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). Paul W Sperduto, T Jonathan Yang, +24 authors, Minesh P Mehta. less JAMA Oncol, 2016 Nov 29; 3(6). PMID: 27892978 Free PMC article. Highly Cited.
Validation of biomarkers to predict response to immunotherapy in cancer: Volume I - pre-analytical and analytical validation. Giuseppe V Masucci, Alessandra Cesano, +10 authors, Magdalena Thurin. less J Immunother Cancer, 2016 Nov 30; 4. PMID: 27895917 Free PMC article. Highly Cited. Review.
Population Pharmacokinetic/Pharmacodynamic Modeling of Tumor Size Dynamics in Pembrolizumab-Treated Advanced Melanoma. M S Chatterjee, J Elassaiss-Schaap, +9 authors, D P de Alwis. less CPT Pharmacometrics Syst Pharmacol, 2016 Nov 30; 6(1). PMID: 27896938 Free PMC article.
Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification. Stefan Gröschel, Martin Bommer, +20 authors, Stefan Fröhling. less Cold Spring Harb Mol Case Stud, 2016 Dec 03; 2(6). PMID: 27900363 Free PMC article.
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations. Daniel Sanghoon Shin, Jesse M Zaretsky, +24 authors, Antoni Ribas. less Cancer Discov, 2016 Dec 03; 7(2). PMID: 27903500 Free PMC article. Highly Cited.
What does PD-L1 positive or negative mean? Antoni Ribas, Siwen Hu-Lieskovan. J Exp Med, 2016 Dec 03; 213(13). PMID: 27903604 Free PMC article. Highly Cited. Review.
Robust detection of immune transcripts in FFPE samples using targeted RNA sequencing. Benjamin E Paluch, Sean T Glenn, +14 authors, Carl D Morrison. less Oncotarget, 2016 Dec 03; 8(2). PMID: 27911273 Free PMC article.
Lung Cancer Biomarkers. Pamela Villalobos, Ignacio I Wistuba. Hematol Oncol Clin North Am, 2016 Dec 04; 31(1). PMID: 27912828 Free PMC article. Review.
Pharmacological and immunological targeting of tumor mesenchymalization. Justin M David, Charli Dominguez, Claudia Palena. Pharmacol Ther, 2016 Dec 06; 170. PMID: 27916651 Free PMC article. Review.
First- and Second-Line Targeted Systemic Therapy in Hepatocellular Carcinoma-An Update on Patient Selection and Response Evaluation. Johann von Felden, Kornelius Schulze, +2 authors, Ines Gil-Ibanez, Tobias Werner, Henning Wege. less Diagnostics (Basel), 2016 Dec 06; 6(4). PMID: 27916795 Free PMC article. Review.
Randomized Phase 2 Trial of Pharmacodynamic Separation of Pemetrexed and Intercalated Erlotinib Versus Pemetrexed Alone for Advanced Nonsquamous, Non-small-cell Lung Cancer. Tianhong Li, Bilal Piperdi, +14 authors, Roman Perez-Soler. less Clin Lung Cancer, 2016 Dec 07; 18(1). PMID: 27919627 Free PMC article.
Regulation of PD-L1 expression in a high-grade invasive human oral squamous cell carcinoma microenvironment. Mariko Hirai, Hiroko Kitahara, +4 authors, Shuichi Kawashiri. less Int J Oncol, 2016 Dec 07; 50(1). PMID: 27922697 Free PMC article.
Predictive biomarkers for checkpoint inhibitor-based immunotherapy. Geoffrey T Gibney, Louis M Weiner, Michael B Atkins. Lancet Oncol, 2016 Dec 08; 17(12). PMID: 27924752 Free PMC article. Highly Cited. Review.
A randomized Phase II trial of the tumor vascular disrupting agent CA4P (fosbretabulin tromethamine) with carboplatin, paclitaxel, and bevacizumab in advanced nonsquamous non-small-cell lung cancer. Edward B Garon, Jeffrey D Neidhart, +3 authors, Fairooz Kabbinavar. less Onco Targets Ther, 2016 Dec 13; 9. PMID: 27942221 Free PMC article.
Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy. Sadakatsu Ikeda, Aaron M Goodman, +6 authors, Razelle Kurzrock. less NPJ Genom Med, 2016 Dec 13; 1. PMID: 27942391 Free PMC article.
Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade. Tavi Nathanson, Arun Ahuja, +8 authors, Jeff Hammerbacher. less Cancer Immunol Res, 2016 Dec 14; 5(1). PMID: 27956380 Free PMC article.
Immunotherapy in the Precision Medicine Era: Melanoma and Beyond. Mack Y Su, David E Fisher. PLoS Med, 2016 Dec 14; 13(12). PMID: 27959922 Free PMC article.
Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study. Stephen J Luen, Roberto Salgado, +8 authors, Sherene Loi. less Lancet Oncol, 2016 Dec 15; 18(1). PMID: 27964843 Free PMC article. Highly Cited.
Innate immune signaling and regulation in cancer immunotherapy. Leticia Corrales, Vyara Matson, +2 authors, Blake Flood, Stefani Spranger, Thomas F Gajewski. less Cell Res, 2016 Dec 17; 27(1). PMID: 27981969 Free PMC article. Highly Cited. Review.
The addition of anti-angiogenic tyrosine kinase inhibitors to chemotherapy for patients with advanced non-small-cell lung cancers: A meta-analysis of randomized trials. Bob T Li, Tristan A Barnes, +9 authors, Nick Pavlakis. less Lung Cancer, 2016 Dec 19; 102. PMID: 27987583 Free PMC article.
Pembrolizumab induced bulbar myopathy and respiratory failure with necrotizing myositis of the diaphragm. C L Haddox, N Shenoy, +5 authors, M P Goetz. less Ann Oncol, 2016 Dec 21; 28(3). PMID: 27993808 Free PMC article.
Immune Checkpoint Blockade in Hepatocellular Carcinoma: 2017 Update. M Kudo. Liver Cancer, 2016 Dec 21; 6(1). PMID: 27995082 Free PMC article.
Immuno-Oncology: The Third Paradigm in Early Drug Development. Juan Martin-Liberal, Cinta Hierro, Maria Ochoa de Olza, Jordi Rodon. Target Oncol, 2016 Dec 21; 12(2). PMID: 27995439
Antibody-mediated thyroid dysfunction during T-cell checkpoint blockade in patients with non-small-cell lung cancer. J C Osorio, A Ni, +11 authors, M D Hellmann. less Ann Oncol, 2016 Dec 22; 28(3). PMID: 27998967 Free PMC article. Highly Cited.
Immunotherapy of Malignant Tumors in the Brain: How Different from Other Sites? Valérie Dutoit, Denis Migliorini, Pierre-Yves Dietrich, Paul R Walker. Front Oncol, 2016 Dec 23; 6. PMID: 28003994 Free PMC article. Review.
Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine. Masayuki Nagahashi, Toshifumi Wakai, +25 authors, Stephen Lyle. less Genome Med, 2016 Dec 23; 8(1). PMID: 28007036 Free PMC article.
Clinical Impact of Frequent Surveillance Imaging in the First Year Following Chemoradiation for Locally Advanced Non-small-cell Lung Cancer. Quoc-Anh Ho, Nima K Harandi, Megan E Daly. Clin Lung Cancer, 2016 Dec 23; 18(4). PMID: 28007410 Free PMC article.
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation. Kankana Bardhan, Theodora Anagnostou, Vassiliki A Boussiotis. Front Immunol, 2016 Dec 27; 7. PMID: 28018338 Free PMC article. Highly Cited. Review.
Immune-related response assessment during PD-1 inhibitor therapy in advanced non-small-cell lung cancer patients. Mizuki Nishino, Nikhil H Ramaiya, +5 authors, Mark M Awad. less J Immunother Cancer, 2016 Dec 27; 4. PMID: 28018599 Free PMC article.
Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer. Valsamo Anagnostou, Kellie N Smith, +26 authors, Victor E Velculescu. less Cancer Discov, 2016 Dec 30; 7(3). PMID: 28031159 Free PMC article. Highly Cited.
Systemic therapy of brain metastases: non-small cell lung cancer, breast cancer, and melanoma. Marc C Chamberlain, Christina S Baik, +2 authors, Laura Q M Chow. less Neuro Oncol, 2016 Dec 30; 19(1). PMID: 28031389 Free PMC article. Review.
Potential role of immunotherapy in advanced non-small-cell lung cancer. Ramon Andrade de Mello, Ana Flávia Veloso, +2 authors, Paulo Esrom Catarina, Sara Nadine, Georgios Antoniou. less Onco Targets Ther, 2016 Dec 30; 10. PMID: 28031719 Free PMC article. Review.
Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol. Xiao-Yi Tang, Yao Sun, +5 authors, Hu Chen. less BMJ Open, 2017 Jan 01; 6(12). PMID: 28039295 Free PMC article.
Independent prognostic role of PD-L1expression in patients with esophageal squamous cell carcinoma. Dongxian Jiang, Qi Song, +9 authors, Yingyong Hou. less Oncotarget, 2017 Jan 01; 8(5). PMID: 28039448 Free PMC article.
Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity. W Joost Lesterhuis, Anthony Bosco, +3 authors, Richard A Lake. less Nat Rev Drug Discov, 2017 Jan 07; 16(4). PMID: 28057932 Highly Cited. Review.
Programmed death-ligand 1 expression in rectal cancer. G Jomrich, G R Silberhumer, +2 authors, B Marian, A Beer, L Müllauer. less Eur Surg, 2017 Jan 07; 48(6). PMID: 28058043 Free PMC article.
PD-L1 testing, fit for routine evaluation? From a pathologist's point of view. Georg Hutarew. Memo, 2017 Jan 07; 9(4). PMID: 28058063 Free PMC article. Review.
Heterogeneous expression of PD-L1 in pulmonary squamous cell carcinoma and adenocarcinoma: implications for assessment by small biopsy. Thomas J Gniadek, Qing Kay Li, +3 authors, Edward Gabrielson. less Mod Pathol, 2017 Jan 07; 30(4). PMID: 28059094
The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment. Shona A Hendry, Rae H Farnsworth, +3 authors, Stephen B Fox. less Front Immunol, 2017 Jan 10; 7. PMID: 28066431 Free PMC article. Highly Cited. Review.
PD-L1 expression in lung cancer. Chad Tang, Joe Y Chang. J Thorac Dis, 2017 Jan 10; 8(11). PMID: 28066581 Free PMC article.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy. Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger. Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373 Free PMC article. Highly Cited. Review.
Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape. Takuro Noguchi, Jeffrey P Ward, +8 authors, Robert D Schreiber. less Cancer Immunol Res, 2017 Jan 12; 5(2). PMID: 28073774 Free PMC article. Highly Cited.
Perioperative chemotherapy in upper tract urothelial carcinoma: a comprehensive review. Atiqullah Aziz, Jakub Dobruch, +11 authors, Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology. less World J Urol, 2017 Jan 12; 35(9). PMID: 28074261 Review.
COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells. Victor Prima, Lyudmila N Kaliberova, +2 authors, Sergey Kaliberov, David T Curiel, Sergei Kusmartsev. less Proc Natl Acad Sci U S A, 2017 Jan 18; 114(5). PMID: 28096371 Free PMC article. Highly Cited.
SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells. Tom L Stephen, Kyle K Payne, +11 authors, Jose R Conejo-Garcia. less Immunity, 2017 Jan 19; 46(1). PMID: 28099864 Free PMC article. Highly Cited.
Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira Mellman. Nature, 2017 Jan 20; 541(7637). PMID: 28102259 Highly Cited. Review.
Correlation between Classic Driver Oncogene Mutations in EGFR, ALK, or ROS1 and 22C3-PD-L1 ≥50% Expression in Lung Adenocarcinoma. Deepa Rangachari, Paul A VanderLaan, +4 authors, Daniel B Costa. less J Thorac Oncol, 2017 Jan 21; 12(5). PMID: 28104537 Free PMC article. Highly Cited.
Cancer immunotherapy - immune checkpoint blockade and associated endocrinopathies. David J Byun, Jedd D Wolchok, Lynne M Rosenberg, Monica Girotra. Nat Rev Endocrinol, 2017 Jan 21; 13(4). PMID: 28106152 Free PMC article. Highly Cited. Review.
New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone. Siwen Hu-Lieskovan, Antoni Ribas. Cancer J, 2017 Jan 24; 23(1). PMID: 28114250 Free PMC article. Review.
Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma. Joseph P Antonios, Horacio Soto, +12 authors, Robert M Prins. less Neuro Oncol, 2017 Jan 25; 19(6). PMID: 28115578 Free PMC article. Highly Cited.
Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis. Hui Zhang, Ryu Watanabe, +5 authors, Cornelia M Weyand. less Proc Natl Acad Sci U S A, 2017 Jan 25; 114(6). PMID: 28115719 Free PMC article. Highly Cited.
Accuracy of transbronchial biopsy as a rebiopsy method for patients with relapse of advanced non-small-cell lung cancer after systemic chemotherapy. Hidenobu Ishii, Koichi Azuma, +5 authors, Tomoaki Hoshino. less BMJ Open Respir Res, 2017 Jan 27; 4(1). PMID: 28123750 Free PMC article.
Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy. Henoch S Hong, Sven D Koch, +9 authors, James M Billingsley. less Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123889 Free PMC article.
Immune contexture and histological response after neoadjuvant chemotherapy predict clinical outcome of lung cancer patients. Romain Remark, Audrey Lupo, +8 authors, Diane Damotte. less Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123901 Free PMC article.
Organizing pneumonia following treatment with pembrolizumab for metastatic malignant melanoma - A case report. R Kuint, M Lotem, +5 authors, Z G Fridlender. less Respir Med Case Rep, 2017 Jan 28; 20. PMID: 28127529 Free PMC article.
PD-L1 Expression in Pancreatic Cancer. Lei Zheng. J Natl Cancer Inst, 2017 Jan 31; 109(6). PMID: 28131993 Free PMC article.
Medication-associated gastrointestinal tract injury. Michael Vieth, Elizabeth Montgomery. Virchows Arch, 2017 Jan 31; 470(3). PMID: 28133700 Review.
Immune Modulation by Androgen Deprivation and Radiation Therapy: Implications for Prostate Cancer Immunotherapy. Jennifer L Kalina, David S Neilson, +4 authors, Julian J Lum. less Cancers (Basel), 2017 Jan 31; 9(2). PMID: 28134800 Free PMC article. Review.
PD-L1 protein expression assessed by immunohistochemistry is neither prognostic nor predictive of benefit from adjuvant chemotherapy in resected non-small cell lung cancer. M-S Tsao, G Le Teuff, +11 authors, E Brambilla. less Ann Oncol, 2017 Feb 01; 28(4). PMID: 28137741 Free PMC article. Highly Cited.
The development of dendritic cell vaccine-based immunotherapies for glioblastoma. David A Reardon, Duane A Mitchell. Semin Immunopathol, 2017 Feb 01; 39(2). PMID: 28138787 Review.
The significance of programmed cell death ligand 1 expression in resected lung adenocarcinoma. Shafei Wu, Xiaohua Shi, +5 authors, Xuan Zeng. less Oncotarget, 2017 Feb 02; 8(10). PMID: 28145884 Free PMC article.
Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis. Elma Kadić, Raymond J Moniz, +2 authors, Ying Huo, An Chi, Ilona Kariv. less BMC Immunol, 2017 Feb 06; 18(1). PMID: 28148223 Free PMC article.
Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?-current evidence and future perspectives. Grainne M O'Kane, Natasha B Leighl. Transl Lung Cancer Res, 2017 Feb 06; 5(6). PMID: 28149757 Free PMC article. Review.
Metastatic lymphoepithelioma-like carcinoma of the lung treated with nivolumab: a case report and focused review of literature. Chul Kim, Arun Rajan, Pedro A DeBrito, Giuseppe Giaccone. Transl Lung Cancer Res, 2017 Feb 06; 5(6). PMID: 28149767 Free PMC article.
Going into BATTLE: umbrella and basket clinical trials to accelerate the study of biomarker-based therapies. Sawsan Rashdan, David E Gerber. Ann Transl Med, 2017 Feb 06; 4(24). PMID: 28149890 Free PMC article.
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy. Takeru Asano, Yusuke Meguri, +17 authors, Ken-Ichi Matsuoka. less Blood, 2017 Feb 06; 129(15). PMID: 28151427 Free PMC article. Highly Cited.
Immune Checkpoint Blockade and Hematopoietic Stem Cell Transplant. Reid W Merryman, Philippe Armand. Curr Hematol Malig Rep, 2017 Feb 06; 12(1). PMID: 28155012 Review.
An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Shuguang Tan, Hao Zhang, +13 authors, Jinghua Yan. less Nat Commun, 2017 Feb 07; 8. PMID: 28165004 Free PMC article. Highly Cited.
PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression. Shiping Jiao, Weiya Xia, +15 authors, Mien-Chie Hung. less Clin Cancer Res, 2017 Feb 09; 23(14). PMID: 28167507 Free PMC article. Highly Cited.
Next steps in immuno-oncology: enhancing antitumor effects through appropriate patient selection and rationally designed combination strategies. A K S Salama, S J Moschos. Ann Oncol, 2017 Feb 09; 28(1). PMID: 28177433 Free PMC article. Review.
DNA vaccines for prostate cancer. Christopher D Zahm, Viswa Teja Colluru, Douglas G McNeel. Pharmacol Ther, 2017 Feb 12; 174. PMID: 28185916 Free PMC article. Review.
Applications of Immunogenomics to Cancer. X Shirley Liu, Elaine R Mardis. Cell, 2017 Feb 12; 168(4). PMID: 28187283 Free PMC article. Highly Cited. Review.
Renal complications of immune checkpoint blockade. Naoka Murakami, Shveta Motwani, Leonardo V Riella. Curr Probl Cancer, 2017 Feb 13; 41(2). PMID: 28189263 Free PMC article. Review.
CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Shu Su, Zhengyun Zou, +12 authors, Baorui Liu. less Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197365 Free PMC article.
Development of Cancer Vaccines Targeting Brachyury, a Transcription Factor Associated with Tumor Epithelial-Mesenchymal Transition. Duane H Hamilton, Justin M David, Charli Dominguez, Claudia Palena. Cells Tissues Organs, 2017 Feb 20; 203(2). PMID: 28214895 Free PMC article. Review.
Economic burden of patients affected by non-small cell lung cancer (NSCLC): the LIFE study. Maria Rita Migliorino, Antonio Santo, +13 authors, Filippo de Marinis. less J Cancer Res Clin Oncol, 2017 Feb 20; 143(5). PMID: 28215027
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice. Janet Lau, Jeanne Cheung, +17 authors, Maike Schmidt. less Nat Commun, 2017 Feb 22; 8. PMID: 28220772 Free PMC article. Highly Cited.
PD-L1 Studies Across Tumor Types, Its Differential Expression and Predictive Value in Patients Treated with Immune Checkpoint Inhibitors. Harriet M Kluger, Christopher R Zito, +9 authors, Lucia B Jilaveanu. less Clin Cancer Res, 2017 Feb 23; 23(15). PMID: 28223273 Free PMC article.
[Progress of PD-1/PD-L1 Inhibitors in Non-small Cell Lung Cancer]. Zhansheng Jiang, Zhanyu Pan, Xiubao Ren. Zhongguo Fei Ai Za Zhi, 2017 Feb 24; 20(2). PMID: 28228226 Free PMC article. Review.
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer. Andreas D Hartkopf, Florin-Andrei Taran, +4 authors, Sara Y Brucker. less Breast Care (Basel), 2017 Feb 24; 11(6). PMID: 28228704 Free PMC article. Review.
Current Diagnosis and Management of Immune Related Adverse Events (irAEs) Induced by Immune Checkpoint Inhibitor Therapy. Vivek Kumar, Neha Chaudhary, +3 authors, Abhinav B Chandra. less Front Pharmacol, 2017 Feb 24; 8. PMID: 28228726 Free PMC article. Highly Cited. Review.
Targeting neoantigens to augment antitumour immunity. Mark Yarchoan, Burles A Johnson, +2 authors, Eric R Lutz, Daniel A Laheru, Elizabeth M Jaffee. less Nat Rev Cancer, 2017 Feb 25; 17(4). PMID: 28233802 Free PMC article. Highly Cited. Review.
Thrombocytopenia in patients with melanoma receiving immune checkpoint inhibitor therapy. Eileen Shiuan, Kathryn E Beckermann, +11 authors, Douglas Johnson. less J Immunother Cancer, 2017 Feb 28; 5. PMID: 28239462 Free PMC article.
Combination immunotherapy: a road map. Patrick A Ott, F Stephen Hodi, +2 authors, Howard L Kaufman, Jon M Wigginton, Jedd D Wolchok. less J Immunother Cancer, 2017 Feb 28; 5. PMID: 28239469 Free PMC article. Highly Cited. Review.
Targeting the programmed death-1 pathway in lymphoid neoplasms. Chi Young Ok, Ken H Young. Cancer Treat Rev, 2017 Mar 01; 54. PMID: 28242522 Free PMC article. Review.
Survival Gains from First-Line Systemic Therapy in Metastatic Non-Small Cell Lung Cancer in the U.S., 1990-2015: Progress and Opportunities. Joshua A Roth, Bernardo H L Goulart, +2 authors, Arliene Ravelo, Holli Kolkey, Scott D Ramsey. less Oncologist, 2017 Mar 01; 22(3). PMID: 28242792 Free PMC article.
Second-Line Treatment of NSCLC-The Pan-ErbB Inhibitor Afatinib in Times of Shifting Paradigms. Jens Köhler. Front Med (Lausanne), 2017 Mar 01; 4. PMID: 28243590 Free PMC article. Review.
A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma. Andrew C Birkeland, Paul L Swiecicki, J Chad Brenner, Andrew G Shuman. Expert Rev Precis Med Drug Dev, 2016 Jan 01; 1(4). PMID: 28251187 Free PMC article.
Gene signature driving invasive mucinous adenocarcinoma of the lung. Minzhe Guo, Koichi Tomoshige, +11 authors, Yutaka Maeda. less EMBO Mol Med, 2017 Mar 04; 9(4). PMID: 28255028 Free PMC article.
Emerging challenges of advanced squamous cell lung cancer. Yi-Chen Zhang, Qing Zhou, Yi-Long Wu. ESMO Open, 2017 Mar 04; 1(6). PMID: 28255454 Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors. Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim. Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545 Free PMC article. Review.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma. Liliana E Lucca, David A Hafler. Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258696 Free PMC article. Review.
Update on targeted therapies for advanced non-small cell lung cancer: nivolumab in context. Alexander D Le, Saeed K Alzghari, Gary W Jean, Ninh M La-Beck. Ther Clin Risk Manag, 2017 Mar 07; 13. PMID: 28260909 Free PMC article. Review.
Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma. Naoya Yamazaki, Yoshio Kiyohara, +11 authors, Hideaki Tahara. less Cancer Sci, 2017 Mar 08; 108(5). PMID: 28266140 Free PMC article.
iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics. Lesley Seymour, Jan Bogaerts, +16 authors, RECIST working group. less Lancet Oncol, 2017 Mar 09; 18(3). PMID: 28271869 Free PMC article. Highly Cited. Review.
PD-1, PD-L1 Protein Expression in Non-Small Cell Lung Cancer and Their Relationship with Tumor-Infiltrating Lymphocytes. Yayi He, Leslie Rozeboom, +5 authors, Fred R Hirsch. less Med Sci Monit, 2017 Mar 10; 23. PMID: 28275222 Free PMC article.
A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer. David L Rimm, Gang Han, +17 authors, Ignacio I Wistuba. less JAMA Oncol, 2017 Mar 10; 3(8). PMID: 28278348 Free PMC article. Highly Cited.
Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy. Motonobu Saito, Hiroyuki Suzuki, +2 authors, Koji Kono, Seiichi Takenoshita, Takashi Kohno. less Surg Today, 2017 Mar 11; 48(1). PMID: 28280984 Review.
Successes and failures: what did we learn from recent first-line treatment immunotherapy trials in non-small cell lung cancer? Jordi Remon, Benjamin Besse, Jean-Charles Soria. BMC Med, 2017 Mar 14; 15(1). PMID: 28285592 Free PMC article. Review.
The high price of anticancer drugs: origins, implications, barriers, solutions. Vinay Prasad, Kevin De Jesús, Sham Mailankody. Nat Rev Clin Oncol, 2017 Mar 16; 14(6). PMID: 28290490 Highly Cited. Review.
Pembrolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives. Ashwin Somasundaram, Timothy F Burns. Lung Cancer (Auckl), 2017 Mar 16; 8. PMID: 28293123 Free PMC article. Review.
TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action. Wenwen Du, Min Yang, +5 authors, Binfeng Lu. less Int J Mol Sci, 2017 Mar 17; 18(3). PMID: 28300768 Free PMC article. Review.
Retrospective Molecular Epidemiology Study of PD-L1 Expression in Patients with EGFR-Mutant Non-small Cell Lung Cancer. Jong Ho Cho, Wei Zhou, +7 authors, Jhingook Kim. less Cancer Res Treat, 2017 Mar 18; 50(1). PMID: 28301925 Free PMC article.
Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. Liliana E Lucca, David A Hafler. J Clin Invest, 2017 Mar 21; 127(4). PMID: 28319049 Free PMC article.
Pembrolizumab for Platinum- and Cetuximab-Refractory Head and Neck Cancer: Results From a Single-Arm, Phase II Study. Joshua Bauml, Tanguy Y Seiwert, +15 authors, Robert Haddad. less J Clin Oncol, 2017 Mar 23; 35(14). PMID: 28328302 Free PMC article. Highly Cited.
Utility of PD-L1 immunohistochemistry assays for predicting PD-1/PD-L1 inhibitor response. Laurence P Diggs, Eddy C Hsueh. Biomark Res, 2017 Mar 24; 5. PMID: 28331612 Free PMC article. Highly Cited. Review.
Systematic evaluation of immune regulation and modulation. David F Stroncek, Lisa H Butterfield, +12 authors, Barbara Seliger. less J Immunother Cancer, 2017 Mar 24; 5. PMID: 28331613 Free PMC article. Review.
Development of CAR T cells designed to improve antitumor efficacy and safety. Janneke E Jaspers, Renier J Brentjens. Pharmacol Ther, 2017 Mar 28; 178. PMID: 28342824 Free PMC article. Review.
Systematic literature review of efficacy, safety and tolerability outcomes of chemotherapy regimens in patients with metastatic Merkel cell carcinoma. Paul Nghiem, Howard L Kaufman, +3 authors, Jürgen C Becker. less Future Oncol, 2017 Mar 30; 13(14). PMID: 28350180 Free PMC article. Systematic Review.
Clinical Determinants of Durable Clinical Benefit of Pembrolizumab in Veterans With Advanced Non-Small-Cell Lung Cancer. Angel Qin, Lindsay Street, +4 authors, Nithya Ramnath. less Clin Lung Cancer, 2017 Apr 04; 18(5). PMID: 28366756 Free PMC article.
Delayed pseudoprogression of lung adenocarcinoma accompanied with interstitial lung disease during chemotherapy after nivolumab treatment. Toru Kumagai, Madoka Kimura, +3 authors, Fumio Imamura. less Thorac Cancer, 2017 Apr 04; 8(3). PMID: 28371397 Free PMC article.
Avelumab for patients with previously treated metastatic or recurrent non-small-cell lung cancer (JAVELIN Solid Tumor): dose-expansion cohort of a multicentre, open-label, phase 1b trial. James L Gulley, Arun Rajan, +11 authors, Karen Kelly. less Lancet Oncol, 2017 Apr 05; 18(5). PMID: 28373005 Free PMC article. Highly Cited.
Current Treatment Algorithms for Patients with Metastatic Non-Small Cell, Non-Squamous Lung Cancer. Barbara Melosky. Front Oncol, 2017 Apr 05; 7. PMID: 28373963 Free PMC article. Review.
Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment. James L Gulley, Ravi A Madan, +4 authors, Charles G Drake. less J Natl Cancer Inst, 2017 Apr 05; 109(4). PMID: 28376158 Free PMC article. Highly Cited. Review.
Cancer immunotherapies targeting the PD-1 signaling pathway. Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo. J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884 Free PMC article. Highly Cited. Review.
A novel bispecific c-MET/PD-1 antibody with therapeutic potential in solid cancer. Zu-Jun Sun, Yi Wu, +4 authors, Min Yu. less Oncotarget, 2017 Apr 14; 8(17). PMID: 28404966 Free PMC article.
PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells. Xinru Wei, Yunxin Lai, +17 authors, Peng Li. less Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405515 Free PMC article.
Treatment Paradigms for Advanced Non-Small Cell Lung Cancer at Academic Medical Centers: Involvement in Clinical Trial Endpoint Design. Charu Aggarwal, Hossein Borghaei. Oncologist, 2017 Apr 15; 22(6). PMID: 28408617 Free PMC article. Review.
Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers. Katrijn Broos, Marleen Keyaerts, +7 authors, Nick Devoogdt. less Oncotarget, 2017 Apr 15; 8(26). PMID: 28410210 Free PMC article.
Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC. Paul C Tumeh, Matthew D Hellmann, +31 authors, Adil Daud. less Cancer Immunol Res, 2017 Apr 16; 5(5). PMID: 28411193 Free PMC article. Highly Cited.
Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL. Wei Ding, Betsy R LaPlant, +32 authors, Stephen M Ansell. less Blood, 2017 Apr 21; 129(26). PMID: 28424162 Free PMC article. Highly Cited.
Update on Programmed Death-1 and Programmed Death-Ligand 1 Inhibition in the Treatment of Advanced or Metastatic Non-Small Cell Lung Cancer. Marco A J Iafolla, Rosalyn A Juergens. Front Oncol, 2017 Apr 22; 7. PMID: 28428947 Free PMC article. Review.
The next generation of immunotherapy: keeping lung cancer in check. Ashwin Somasundaram, Timothy F Burns. J Hematol Oncol, 2017 Apr 25; 10(1). PMID: 28434399 Free PMC article. Review.
Immunotherapy with single agent nivolumab for advanced leiomyosarcoma of the uterus: Results of a phase 2 study. Eytan Ben-Ami, Constance M Barysauskas, +15 authors, Suzanne George. less Cancer, 2017 Apr 26; 123(17). PMID: 28440953 Free PMC article. Highly Cited.
Cellular Expression of PD-L1 in the Peripheral Blood of Lung Cancer Patients is Associated with Worse Survival. Daniel J Boffa, Ryon P Graf, +14 authors, Jorge Nieva. less Cancer Epidemiol Biomarkers Prev, 2017 Apr 28; 26(7). PMID: 28446544 Free PMC article.
Anti-PD-1/PD-L1 antibody versus conventional chemotherapy for previously-treated, advanced non-small-cell lung cancer: a meta-analysis of randomized controlled trials. Yongxun Zhuansun, Fengting Huang, +3 authors, Yumo Du, Lin Lin, Rui Chen, Jianguo Li. less J Thorac Dis, 2017 Apr 30; 9(3). PMID: 28449473 Free PMC article.
Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal. P A Ott, S A Piha-Paul, +13 authors, J Bennouna. less Ann Oncol, 2017 Apr 30; 28(5). PMID: 28453692 Free PMC article. Highly Cited.
Emerging therapies for breast cancer. Xichun Hu, Wei Huang, Minhao Fan. J Hematol Oncol, 2017 Apr 30; 10(1). PMID: 28454587 Free PMC article. Review.
Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy. Hengfeng Yuan, Wen Jiang, +9 authors, Betty Y S Kim. less Nat Nanotechnol, 2017 May 02; 12(8). PMID: 28459470
PD-L1 expression and its relationship with oncogenic drivers in non-small cell lung cancer (NSCLC). Liyan Jiang, Xinying Su, +18 authors, Yi Gu. less Oncotarget, 2017 May 04; 8(16). PMID: 28460468 Free PMC article.
Outcomes targeting the PD-1/PD-L1 axis in conjunction with stereotactic radiation for patients with non-small cell lung cancer brain metastases. Kamran A Ahmed, Sungjune Kim, +12 authors, Bradford A Perez. less J Neurooncol, 2017 May 04; 133(2). PMID: 28466250
CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease. Ruchi Srivastava, Arif A Khan, +5 authors, Lbachir BenMohamed. less J Virol, 2017 May 05; 91(14). PMID: 28468883 Free PMC article.
Phase I Trial of Intratumoral Injection of CCL21 Gene-Modified Dendritic Cells in Lung Cancer Elicits Tumor-Specific Immune Responses and CD8+ T-cell Infiltration. Jay M Lee, Mi-Heon Lee, +23 authors, Steven M Dubinett. less Clin Cancer Res, 2017 May 05; 23(16). PMID: 28468947 Free PMC article.
Real-Time Reverse-Transcription Quantitative Polymerase Chain Reaction Assay Is a Feasible Method for the Relative Quantification of Heregulin Expression in Non-Small Cell Lung Cancer Tissue. Jessica Kristof, Kellen Sakrison, +6 authors, Wenqin Feng. less Biomark Insights, 2017 May 05; 12. PMID: 28469400 Free PMC article.
Impact of Age on Outcomes with Immunotherapy for Patients with Melanoma. Allison S Betof, Ryan D Nipp, +7 authors, Ryan J Sullivan. less Oncologist, 2017 May 10; 22(8). PMID: 28476944 Free PMC article.
The KEY to the end of chemotherapy in non-small cell lung cancer? Yiqing Huang, Ross A Soo. Ann Transl Med, 2017 May 10; 5(7). PMID: 28480202 Free PMC article.
Pembrolizumab-induced pneumonitis. Vincent Leroy, Carole Templier, +4 authors, Lidwine Wemeau-Stervinou. less ERJ Open Res, 2017 May 10; 3(2). PMID: 28480216 Free PMC article.
Checkpoint inhibitors in hematological malignancies. Chi Young Ok, Ken H Young. J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851 Free PMC article. Highly Cited. Review.
Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade. Esra A Akbay, Shohei Koyama, +21 authors, Kwok-Kin Wong. less J Thorac Oncol, 2017 May 10; 12(8). PMID: 28483607 Free PMC article. Highly Cited.
Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer. Kentaro Inamura. Cancers (Basel), 2017 May 10; 9(5). PMID: 28486396 Free PMC article. Review.
Major Tumor Suppressor and Oncogenic Non-Coding RNAs: Clinical Relevance in Lung Cancer. Kentaro Inamura. Cells, 2017 May 10; 6(2). PMID: 28486418 Free PMC article. Review.
The Potential of Cellular- and Viral-Based Immunotherapies for Malignant Glioma-Dendritic Cell Vaccines, Adoptive Cell Transfer, and Oncolytic Viruses. Russell Maxwell, Andrew S Luksik, Tomas Garzon-Muvdi, Michael Lim. Curr Neurol Neurosci Rep, 2017 May 11; 17(6). PMID: 28488122 Review.
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sean P Arlauckas, Christopher S Garris, +9 authors, Mikael J Pittet. less Sci Transl Med, 2017 May 12; 9(389). PMID: 28490665 Free PMC article. Highly Cited.
Improving molecular testing and personalized medicine in non-small-cell lung cancer in Ontario. C Lim, H S Sekhon, +14 authors, N B Leighl. less Curr Oncol, 2017 May 12; 24(2). PMID: 28490924 Free PMC article.
Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer. Prabhsimranjot Singh, Sudhamshi Toom, Yiwu Huang. J Hematol Oncol, 2017 May 13; 10(1). PMID: 28494772 Free PMC article. Review.
Immune checkpoint blockade: the role of PD-1-PD-L axis in lymphoid malignancies. Cristina Ilcus, Cristina Bagacean, +5 authors, Mihnea Zdrenghea. less Onco Targets Ther, 2017 May 13; 10. PMID: 28496333 Free PMC article. Review.
Nivolumab for patients with recurrent glioblastoma progressing on bevacizumab: a retrospective case series. Marc C Chamberlain, Bryan T Kim. J Neurooncol, 2017 May 14; 133(3). PMID: 28500559
Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy. Hélène Roussel, Eléonore De Guillebon, +18 authors, Eric Tartour. less Oncoimmunology, 2017 May 17; 6(4). PMID: 28507793 Free PMC article.
Evaluation of dosing strategy for pembrolizumab for oncology indications. Tomoko Freshwater, Anna Kondic, +4 authors, Julie A Stone. less J Immunother Cancer, 2017 May 19; 5. PMID: 28515943 Free PMC article. Highly Cited.
Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy. Sacha Gnjatic, Vincenzo Bronte, +13 authors, Lisa H Butterfield. less J Immunother Cancer, 2017 May 19; 5. PMID: 28515944 Free PMC article. Highly Cited. Review.
PD-1 targeted Immunotherapy as first-line therapy for advanced non-small-cell lung cancer patients. Arik Bernard Schulze, Lars Henning Schmidt. J Thorac Dis, 2017 May 20; 9(4). PMID: 28523184 Free PMC article.
Immunogenomics: using genomics to personalize cancer immunotherapy. Rance C Siniard, Shuko Harada. Virchows Arch, 2017 May 22; 471(2). PMID: 28528510 Review.
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer. Salma K Jabbour, Abigail T Berman, Charles B Simone. Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529894 Free PMC article. Review.
Clinical experiences of combining immunotherapy and radiation therapy in non-small cell lung cancer: lessons from melanoma. Anusha Kalbasi, Ramesh Rengan. Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529899 Free PMC article. Review.
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer. Neil K Taunk, Andreas Rimner, +3 authors, Jamie Chaft. less Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529900 Free PMC article. Review.
Current state of immunotherapy for non-small cell lung cancer. Jyoti Malhotra, Salma K Jabbour, Joseph Aisner. Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529902 Free PMC article. Highly Cited. Review.
Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer. Allison M Campbell, Roy H Decker. Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529904 Free PMC article. Review.
[Detection of Serum Peptides in Patients with Lung Squamous Cell Carcinoma by MALDI-TOF-MS and Analysis of Their Correlation with Chemotherapy Efficacy]. Guanhua Zhao, Bin Xu, +8 authors, Xiaoqing Liu. less Zhongguo Fei Ai Za Zhi, 2017 May 24; 20(5). PMID: 28532539 Free PMC article.
Immune Checkpoint Inhibitor Therapy: What Line of Therapy and How to Choose? Chethan Ramamurthy, James L Godwin, Hossein Borghaei. Curr Treat Options Oncol, 2017 May 24; 18(6). PMID: 28534248 Review.
Immune signature of metastatic breast cancer: Identifying predictive markers of immunotherapy response. Ji-Yeon Kim, Eunjin Lee, +5 authors, Yeon Hee Park. less Oncotarget, 2017 May 26; 8(29). PMID: 28537889 Free PMC article.
Immune Checkpoint Inhibitor-Induced Colitis: Diagnosis and Management. Caroline Prieux-Klotz, Marie Dior, +6 authors, Romain Coriat. less Target Oncol, 2017 May 26; 12(3). PMID: 28540478
New developments in the treatment of advanced squamous cell lung cancer: focus on afatinib. Vera Hirsh. Onco Targets Ther, 2017 May 27; 10. PMID: 28546756 Free PMC article. Review.
Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial. Narek Shaverdian, Aaron E Lisberg, +5 authors, Percy Lee. less Lancet Oncol, 2017 May 30; 18(7). PMID: 28551359 Free PMC article. Highly Cited.
Paradigm shift of therapeutic management of brain metastases in EGFR-mutant non-small cell lung cancer in the era of targeted therapy. Akimasa Sekine, Hiroaki Satoh. Med Oncol, 2017 May 31; 34(7). PMID: 28555261 Review.
Positive Expression of Programmed Death Ligand 1 in Peritumoral Liver Tissue is Associated with Poor Survival after Curative Resection of Hepatocellular Carcinoma. Xiaomeng Dai, Jun Xue, +8 authors, Tao Zhang. less Transl Oncol, 2017 May 31; 10(4). PMID: 28558264 Free PMC article.
Time dependent pharmacokinetics of pembrolizumab in patients with solid tumor and its correlation with best overall response. Hongshan Li, Jingyu Yu, +15 authors, Yaning Wang. less J Pharmacokinet Pharmacodyn, 2017 Jun 03; 44(5). PMID: 28573468
Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity. Ryu Watanabe, Tsuyoshi Shirai, +9 authors, Cornelia M Weyand. less J Clin Invest, 2017 Jun 13; 127(7). PMID: 28604383 Free PMC article.
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. J Feng, H Yang, +7 authors, Z Wu. less Oncogene, 2017 Jun 13; 36(42). PMID: 28604752 Highly Cited.
Pembrolizumab in cervical cancer: latest evidence and clinical usefulness. Edith Borcoman, Christophe Le Tourneau. Ther Adv Med Oncol, 2017 Jun 14; 9(6). PMID: 28607581 Free PMC article. Review.
Phase II Trial of Atezolizumab As First-Line or Subsequent Therapy for Patients With Programmed Death-Ligand 1-Selected Advanced Non-Small-Cell Lung Cancer (BIRCH). Solange Peters, Scott Gettinger, +25 authors, Enriqueta Felip. less J Clin Oncol, 2017 Jun 14; 35(24). PMID: 28609226 Free PMC article. Highly Cited.
Autoimmune Diabetes and Thyroiditis Complicating Treatment with Nivolumab. Li Li, Awais Masood, +2 authors, Shahla Bari, Sahzene Yavuz, Alan B Grosbach. less Case Rep Oncol, 2017 Jun 15; 10(1). PMID: 28611636 Free PMC article.
New insights into the role of EMT in tumor immune escape. Stéphane Terry, Pierre Savagner, +4 authors, Salem Chouaib. less Mol Oncol, 2017 Jun 15; 11(7). PMID: 28614624 Free PMC article. Highly Cited. Review.
Predictive value of PD-L1 based on mRNA level in the treatment of stage IV melanoma with ipilimumab. C Brüggemann, M C Kirchberger, +14 authors, L Heinzerling. less J Cancer Res Clin Oncol, 2017 Jun 16; 143(10). PMID: 28616701
Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Masao Omata, Ann-Lii Cheng, +18 authors, Shiv Kumar Sarin. less Hepatol Int, 2017 Jun 18; 11(4). PMID: 28620797 Free PMC article. Highly Cited. Review.
Programmed death-ligand 1 (PD-L1) is expressed in a significant number of the uterine cervical carcinomas. Opal L Reddy, Peter I Shintaku, Neda A Moatamed. Diagn Pathol, 2017 Jun 19; 12(1). PMID: 28623908 Free PMC article.
Targeting the PD-1/PD-L1 Immune Checkpoint in EGFR-Mutated or ALK-Translocated Non-Small-Cell Lung Cancer. Olivier Bylicki, Nicolas Paleiron, +6 authors, Christos Chouaid. less Target Oncol, 2017 Jun 19; 12(5). PMID: 28624922 Review.
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer. Anusha-Preethi Ganesan, James Clarke, +14 authors, Christian H Ottensmeier. less Nat Immunol, 2017 Jun 20; 18(8). PMID: 28628092 Free PMC article. Highly Cited.
Tumor cells PD-L1 expression as a favorable prognosis factor in nasopharyngeal carcinoma patients with pre-existing intratumor-infiltrating lymphocytes. Qian Zhu, Mu-Yan Cai, +7 authors, Jian-Chuan Xia. less Oncoimmunology, 2017 Jun 24; 6(5). PMID: 28638740 Free PMC article.
Development of an automated size-based filtration system for isolation of circulating tumor cells in lung cancer patients. Satomi Yagi, Yasuhiro Koh, +11 authors, Nobuyuki Yamamoto. less PLoS One, 2017 Jun 24; 12(6). PMID: 28640869 Free PMC article.
[Prospect and Current Situation of Immune Checkpoint Inhibitors  in First-line Treatment in Advanced Non-small Cell Lung Cancer Patients]. Haiyang Wang, Xiaoqing Yu, Yun Fan. Zhongguo Fei Ai Za Zhi, 2017 Jun 24; 20(6). PMID: 28641702 Free PMC article. Review.
Immunotherapy and Targeted Therapy for Small Cell Lung Cancer: There Is Hope. Jonathan M Lehman, Mary E Gwin, Pierre P Massion. Curr Oncol Rep, 2017 Jun 24; 19(7). PMID: 28643173 Review.
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade. Mark Ayers, Jared Lunceford, +12 authors, Terrill K McClanahan. less J Clin Invest, 2017 Jun 27; 127(8). PMID: 28650338 Free PMC article. Highly Cited.
Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy. Yuanzeng Min, Kyle C Roche, +12 authors, Andrew Z Wang. less Nat Nanotechnol, 2017 Jun 27; 12(9). PMID: 28650437 Free PMC article. Highly Cited.
Immune-Related Adverse Events as a Biomarker in Non-Melanoma Patients Treated with Programmed Cell Death 1 Inhibitors. Julia Judd, Matthew Zibelman, +10 authors, Daniel M Geynisman. less Oncologist, 2017 Jun 28; 22(10). PMID: 28652280 Free PMC article.
Clinical features, diagnostic challenges, and management strategies in checkpoint inhibitor-related pneumonitis. Sarah Chuzi, Fabio Tavora, +4 authors, Francis J Giles. less Cancer Manag Res, 2017 Jun 28; 9. PMID: 28652812 Free PMC article. Review.
Monitoring immune-checkpoint blockade: response evaluation and biomarker development. Mizuki Nishino, Nikhil H Ramaiya, Hiroto Hatabu, F Stephen Hodi. Nat Rev Clin Oncol, 2017 Jun 28; 14(11). PMID: 28653677 Free PMC article. Highly Cited. Review.
Bmi-1 overexpression as an efficient prognostic marker in patients with nonsmall cell lung cancer. Xiaojun Zhang, Tian Tian, +2 authors, Wei Sun, Changting Liu, Xiangqun Fang. less Medicine (Baltimore), 2017 Jun 29; 96(26). PMID: 28658153 Free PMC article. Review.
PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability. Hans Brunnström, Anna Johansson, +6 authors, Patrick Micke. less Mod Pathol, 2017 Jul 01; 30(10). PMID: 28664936 Highly Cited.
Tumor Response Dynamics of Advanced Non-small Cell Lung Cancer Patients Treated with PD-1 Inhibitors: Imaging Markers for Treatment Outcome. Mizuki Nishino, Suzanne E Dahlberg, +5 authors, Mark M Awad. less Clin Cancer Res, 2017 Jul 07; 23(19). PMID: 28679767 Free PMC article.
Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression. Julian P Layer, Marie T Kronmüller, +13 authors, Michael Hölzel. less Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680756 Free PMC article.
Patient Reported Outcomes (PROs) as Part of Value-Based Care Can Shape Therapy Guidelines: Impact on Emerging Targeted Agents and Immunotherapy Protocols in Resource-Limited Regions. Frank E Mott. Oncol Ther, 2017 Jul 07; 5(1). PMID: 28680956 Free PMC article.
Pharmacotherapy of Glioblastoma: Established Treatments and Emerging Concepts. Enrico Franceschi, Santino Minichillo, Alba A Brandes. CNS Drugs, 2017 Jul 07; 31(8). PMID: 28681349 Review.
[Radiotherapy enhances the effect of PD-1 checkpoint inhibitors]. René Baumann, Jürgen Dunst. Strahlenther Onkol, 2017 Jul 13; 193(9). PMID: 28698902
Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis. Hyosun Cho, Hyojeung Kang, Hwan Hee Lee, Chang Wook Kim. Int J Mol Sci, 2017 Jul 14; 18(7). PMID: 28703774 Free PMC article. Review.
Development of an intervention to support patients and clinicians with advanced lung cancer when considering systematic anticancer therapy: protocol for the PACT study. Despina Anagnostou, Stephanie Sivell, +5 authors, Annmarie Nelson. less BMJ Open, 2017 Jul 15; 7(7). PMID: 28706092 Free PMC article.
Novel immunotherapy clinical trials in malignant pleural mesothelioma. Zachary E Tano, Navin K Chintala, Xiaoyu Li, Prasad S Adusumilli. Ann Transl Med, 2017 Jul 15; 5(11). PMID: 28706913 Free PMC article.
Cancer Immunotherapies: Are They as Effective in the Elderly? Kate Poropatich, Joel Fontanarosa, +2 authors, Sandeep Samant, Jeffrey A Sosman, Bin Zhang. less Drugs Aging, 2017 Jul 15; 34(8). PMID: 28707274 Review.
Immunotherapy for malignant pleural mesothelioma: current status and future directions. Jordan Dozier, Hua Zheng, Prasad S Adusumilli. Transl Lung Cancer Res, 2017 Jul 18; 6(3). PMID: 28713676 Free PMC article. Review.
Predictive biomarkers of immunotherapy for non-small cell lung cancer: results from an Experts Panel Meeting of the Italian Association of Thoracic Oncology. Cesare Gridelli, Andrea Ardizzoni, +5 authors, Filippo De Marinis. less Transl Lung Cancer Res, 2017 Jul 18; 6(3). PMID: 28713682 Free PMC article. Review.
Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination. Laura E Johnson, Brian M Olson, Douglas G McNeel. J Immunother Cancer, 2017 Jul 19; 5(1). PMID: 28716080 Free PMC article.
Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab. Hyun Tae Lee, Ju Yeon Lee, +6 authors, Yong-Seok Heo. less Sci Rep, 2017 Jul 19; 7(1). PMID: 28717238 Free PMC article.
Comparison of Different Antibody Clones for Immunohistochemistry Detection of Programmed Cell Death Ligand 1 (PD-L1) on Non-Small Cell Lung Carcinoma. Edwin R Parra, Pamela Villalobos, Barbara Mino, Jaime Rodriguez-Canales. Appl Immunohistochem Mol Morphol, 2017 Jul 19; 26(2). PMID: 28719380 Free PMC article.
Immune Surveillance Plays a Role in Locally Aggressive Giant Cell Lesions of Bone. Ahmad Al-Sukaini, Francis J Hornicek, +3 authors, Joseph H Schwab. less Clin Orthop Relat Res, 2017 Jul 21; 475(12). PMID: 28725958 Free PMC article.
Biologic therapy in esophageal and gastric malignancies: current therapies and future directions. Pamela Samson, A Craig Lockhart. J Gastrointest Oncol, 2017 Jul 25; 8(3). PMID: 28736629 Free PMC article. Review.
The immune contexture in cancer prognosis and treatment. Wolf H Fridman, Laurence Zitvogel, Catherine Sautès-Fridman, Guido Kroemer. Nat Rev Clin Oncol, 2017 Jul 26; 14(12). PMID: 28741618 Highly Cited. Review.
PD-1 and PD-L1 as emerging therapeutic targets in gastric cancer: current evidence. Phu N Tran, Sarmen Sarkissian, Joseph Chao, Samuel J Klempner. Gastrointest Cancer, 2017 Aug 02; 7. PMID: 28757801 Free PMC article.
Neopterin as a biomarker of immune response in cancer patients. Bohuslav Melichar, Martina Spisarová, +3 authors, Hana Študentová. less Ann Transl Med, 2017 Aug 02; 5(13). PMID: 28758106 Free PMC article. Review.
New PD-L1 inhibitors in non-small cell lung cancer - impact of atezolizumab. Nagashree Seetharamu, Isabel R Preeshagul, Kevin M Sullivan. Lung Cancer (Auckl), 2017 Aug 02; 8. PMID: 28761384 Free PMC article. Review.
Peritumoural ground-glass opacity associated with tumour pseudoprogression in a patient with non-small cell lung cancer treated with nivolumab. Ryoji Kato, Hidetoshi Hayashi, +3 authors, Kazuhiko Nakagawa. less ESMO Open, 2017 Aug 02; 2(1). PMID: 28761729 Free PMC article.
Tumour-infiltrating lymphocytes are correlated with higher expression levels of PD-1 and PD-L1 in early breast cancer. Atsuko Kitano, Makiko Ono, +11 authors, Kenji Tamura. less ESMO Open, 2017 Aug 02; 2(2). PMID: 28761741 Free PMC article.
Emerging role of nivolumab in the management of patients with non-small-cell lung cancer: current data and future perspectives. Emily Feld, Leora Horn. Onco Targets Ther, 2017 Aug 05; 10. PMID: 28769573 Free PMC article. Review.
Mismatch Repair Deficiency as a Predictive Biomarker for Immunotherapy Efficacy. Giulia Viale, Dario Trapani, Giuseppe Curigliano. Biomed Res Int, 2017 Aug 05; 2017. PMID: 28770222 Free PMC article. Review.
PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy. Junyu Long, Jianzhen Lin, +7 authors, Haitao Zhao. less J Hematol Oncol, 2017 Aug 05; 10(1). PMID: 28774337 Free PMC article. Review.
Pan-urologic cancer genomic subtypes that transcend tissue of origin. Fengju Chen, Yiqun Zhang, +7 authors, Chad J Creighton. less Nat Commun, 2017 Aug 05; 8(1). PMID: 28775315 Free PMC article.
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research. Shona Hendry, Roberto Salgado, +97 authors, Stephen B Fox. less Adv Anat Pathol, 2017 Aug 05; 24(5). PMID: 28777142 Free PMC article. Highly Cited. Review.
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors. Shona Hendry, Roberto Salgado, +97 authors, Stephen B Fox. less Adv Anat Pathol, 2017 Aug 05; 24(6). PMID: 28777143 Free PMC article. Highly Cited. Review.
Expression of programmed death ligand-1 predicts poor outcome in nasopharyngeal carcinoma. Ying-Fei Li, Jian-Wu Ding, +6 authors, Long Huang. less Mol Clin Oncol, 2017 Aug 07; 7(3). PMID: 28781814 Free PMC article.
Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma. Russell Maxwell, Christopher M Jackson, Michael Lim. Curr Treat Options Oncol, 2017 Aug 09; 18(8). PMID: 28785997 Review.
Lung cancer as a cardiotoxic state: a review. David Pérez-Callejo, María Torrente, +2 authors, Mariano Provencio. less Med Oncol, 2017 Aug 11; 34(9). PMID: 28795306 Review.
Use of the 22C3 anti-PD-L1 antibody to determine PD-L1 expression in multiple automated immunohistochemistry platforms. Marius Ilie, Shirin Khambata-Ford, +4 authors, Paul Hofman. less PLoS One, 2017 Aug 11; 12(8). PMID: 28797130 Free PMC article.
Immunotherapy in Breast Cancer: the Emerging Role of PD-1 and PD-L1. François Bertucci, Anthony Gonçalves. Curr Oncol Rep, 2017 Aug 12; 19(10). PMID: 28799073 Review.
Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3. Yong-Chen Lu, Linda L Parker, +14 authors, Steven A Rosenberg. less J Clin Oncol, 2017 Aug 16; 35(29). PMID: 28809608 Free PMC article. Highly Cited.
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Riccardo Mezzadra, Chong Sun, +16 authors, Ton N M Schumacher. less Nature, 2017 Aug 17; 549(7670). PMID: 28813410 Free PMC article. Highly Cited.
Clinical characteristics of patient selection and imaging predictors of outcome in solid tumors treated with checkpoint-inhibitors. Sabrina Rossi, Luca Toschi, +3 authors, Egesta Lopci. less Eur J Nucl Med Mol Imaging, 2017 Aug 18; 44(13). PMID: 28815334 Review.
Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies. Aaron Simpson, Wilfride Petnga, +2 authors, Thomas Bogenrieder. less Target Oncol, 2017 Aug 18; 12(5). PMID: 28815409 Free PMC article. Review.
Pembrolizumab in the treatment of metastatic non-small cell lung cancer: a review of current evidence. Karim Rihawi, Francesco Gelsomino, +4 authors, Andrea Ardizzoni. less Ther Adv Respir Dis, 2017 Aug 19; 11(9). PMID: 28818019 Free PMC article. Review.
The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade. Howard Y Li, Maria McSharry, +8 authors, Raphael A Nemenoff. less Cancer Immunol Res, 2017 Aug 19; 5(9). PMID: 28819064 Free PMC article.
89Zr-labeled nivolumab for imaging of T-cell infiltration in a humanized murine model of lung cancer. Christopher G England, Dawei Jiang, +7 authors, Weibo Cai. less Eur J Nucl Med Mol Imaging, 2017 Aug 20; 45(1). PMID: 28821924 Free PMC article.
Oncolytic reovirus sensitizes multiple myeloma cells to anti-PD-L1 therapy. K R Kelly, C M Espitia, +6 authors, S T Nawrocki. less Leukemia, 2017 Aug 24; 32(1). PMID: 28832023 Free PMC article.
Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers. Aaron M Goodman, Shumei Kato, +6 authors, Razelle Kurzrock. less Mol Cancer Ther, 2017 Aug 25; 16(11). PMID: 28835386 Free PMC article. Highly Cited.
Phase II study of olaratumab with paclitaxel/carboplatin (P/C) or P/C alone in previously untreated advanced NSCLC. David E Gerber, Paul Swanson, +9 authors, Maria Q Baggstrom. less Lung Cancer, 2017 Aug 26; 111. PMID: 28838379 Free PMC article.
Antigen-Presenting Intratumoral B Cells Affect CD4+ TIL Phenotypes in Non-Small Cell Lung Cancer Patients. Tullia C Bruno, Peggy J Ebner, +11 authors, Jill E Slansky. less Cancer Immunol Res, 2017 Aug 30; 5(10). PMID: 28848053 Free PMC article.
Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells. Rachel M Gibbons Johnson, Haidong Dong. Front Immunol, 2017 Aug 30; 8. PMID: 28848559 Free PMC article. Review.
The promise of immunotherapy in head and neck squamous cell carcinoma: combinatorial immunotherapy approaches. Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri. ESMO Open, 2017 Aug 30; 1(6). PMID: 28848660 Free PMC article. Review.
Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors. Carmelo Tibaldi, Alice Lunghi, Editta Baldini. World J Clin Oncol, 2017 Aug 30; 8(4). PMID: 28848698 Free PMC article. Review.
Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings. Ai Uchida, Maho Watanabe, +5 authors, Hitoshi Nakashima. less CEN Case Rep, 2017 Aug 30; 6(2). PMID: 28849361 Free PMC article.
PD-L1 expression in lung cancer and its correlation with driver mutations: a meta-analysis. Minghui Zhang, Guoliang Li, +5 authors, Yan Wang. less Sci Rep, 2017 Sep 02; 7(1). PMID: 28860576 Free PMC article. Highly Cited.
Economic Considerations in the Use of Novel Targeted Therapies for Lung Cancer: Review of Current Literature. Hamzeh Albaba, Charles Lim, Natasha B Leighl. Pharmacoeconomics, 2017 Sep 02; 35(12). PMID: 28861770 Review.
Glioblastoma targeted therapy: updated approaches from recent biological insights. M Touat, A Idbaih, M Sanson, K L Ligon. Ann Oncol, 2017 Sep 03; 28(7). PMID: 28863449 Free PMC article. Highly Cited. Review.
Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity. Valsamo Anagnostou, Mark Yarchoan, +6 authors, Patrick M Forde. less Clin Cancer Res, 2017 Sep 03; 23(17). PMID: 28864724 Free PMC article.
The Challenge for Development of Valuable Immuno-oncology Biomarkers. Janice M Mehnert, Arta M Monjazeb, +3 authors, Lyndsay N Harris. less Clin Cancer Res, 2017 Sep 03; 23(17). PMID: 28864725 Free PMC article.
Immuno-oncology Clinical Trial Design: Limitations, Challenges, and Opportunities. Christina S Baik, Eric H Rubin, +5 authors, Laura Q M Chow. less Clin Cancer Res, 2017 Sep 03; 23(17). PMID: 28864727 Free PMC article.
Immune checkpoint inhibitors in cancer therapy. Eika S Webb, Peng Liu, +3 authors, Yao-He Wang. less J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656 Free PMC article.
Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis. G Chen, B Zhang, +5 authors, H Xu, Y Sun, Y Shi, Y Luo, H Jia, F Wang. less Oncogene, 2017 Sep 05; 36(50). PMID: 28869605
Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy. Weiqiang Zhou, Shanchun Guo, +2 authors, Mingli Liu, Matthew E Burow, Guangdi Wang. less Curr Med Chem, 2017 Sep 07; 26(17). PMID: 28875842 Free PMC article. Review.
The Successful Treatment of Pulmonary Pleomorphic Carcinoma with Pembrolizumab: A Case Report. Yoko Matsumoto, Tamaki Miura, Hajime Horiuchi, Kazuhiro Usui. Case Rep Oncol, 2017 Sep 08; 10(2). PMID: 28878661 Free PMC article.
PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome. Hashem O Alsaab, Samaresh Sau, +4 authors, Arun K Iyer. less Front Pharmacol, 2017 Sep 08; 8. PMID: 28878676 Free PMC article. Highly Cited. Review.
Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells. Xiao-Ming Jiang, Yu-Lian Xu, +4 authors, Jin-Jian Lu. less Acta Pharmacol Sin, 2017 Sep 08; 38(11). PMID: 28880013 Free PMC article.
PD-L1: a novel prognostic biomarker in head and neck squamous cell carcinoma. Tim Müller, Martin Braun, +9 authors, Peter Brossart. less Oncotarget, 2017 Sep 09; 8(32). PMID: 28881780 Free PMC article.
Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN. Andrea Cavazzoni, Silvia La Monica, +15 authors, Elisa Giovannetti. less Oncotarget, 2017 Sep 09; 8(32). PMID: 28881794 Free PMC article.
Adverse prognostic value of PD-L1 expression in primary resected pulmonary squamous cell carcinomas and paired mediastinal lymph node metastases. Manuel D Keller, Christina Neppl, +4 authors, Sabina Berezowska. less Mod Pathol, 2017 Sep 09; 31(1). PMID: 28884747
Safety of checkpoint inhibitors for cancer treatment: strategies for patient monitoring and management of immune-mediated adverse events. Marianne Davies, Emily A Duffield. Immunotargets Ther, 2017 Sep 13; 6. PMID: 28894725 Free PMC article. Review.
The genetic landscape of programmed death ligand-1 (PD-L1) alterations in head and neck cancer. Thomas E Heineman, Adam Widman, Edward C Kuan, Maie St John. Laryngoscope Investig Otolaryngol, 2017 Sep 13; 2(3). PMID: 28894827 Free PMC article.
MafB silencing in macrophages does not influence the initiation and growth of lung cancer induced by urethane. Takako Nemoto, Yoko Shibata, +15 authors, Isao Kubota. less EXCLI J, 2017 Sep 14; 16. PMID: 28900373 Free PMC article.
Genomic Analysis of Tumor Microenvironment Immune Types across 14 Solid Cancer Types: Immunotherapeutic Implications. Yu-Pei Chen, Yu Zhang, +9 authors, Jun Ma. less Theranostics, 2017 Sep 16; 7(14). PMID: 28912897 Free PMC article. Highly Cited.
Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer. Ana C Gregório, Manuela Lacerda, +3 authors, João Nuno Moreira. less Pathol Oncol Res, 2017 Sep 16; 24(4). PMID: 28913723 Review.
Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies. Qing-Ge Zhu, Shi-Ming Zhang, +2 authors, Xiao-Xiao Ding, Bing He, Hu-Qin Zhang. less Oncotarget, 2017 Sep 17; 8(34). PMID: 28915704 Free PMC article. Review.
The efficacy of anti-PD-1/PD-L1 therapy and its comparison with EGFR-TKIs for advanced non-small-cell lung cancer. Zhixin Sheng, Xu Zhu, Yanhua Sun, Yanxia Zhang. Oncotarget, 2017 Sep 17; 8(34). PMID: 28915714 Free PMC article. Review.
Programmed death-ligand 1 (PD-L1) expression in tumour cell and tumour infiltrating lymphocytes of HER2-positive breast cancer and its prognostic value. Ahrong Kim, So Jeong Lee, +7 authors, Kyung Un Choi. less Sci Rep, 2017 Sep 17; 7(1). PMID: 28916815 Free PMC article.
Profile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy. Sulsal Haque, Mahender Yellu, Jaskirat Randhawa, Nooshin Hashemi-Sadraei. Drug Des Devel Ther, 2017 Sep 19; 11. PMID: 28919706 Free PMC article. Review.
Relationship of tumor PD-L1 (CD274) expression with lower mortality in lung high-grade neuroendocrine tumor. Kentaro Inamura, Yusuke Yokouchi, +5 authors, Yuichi Ishikawa. less Cancer Med, 2017 Sep 20; 6(10). PMID: 28925087 Free PMC article.
Predictors of responses to immune checkpoint blockade in advanced melanoma. N Jacquelot, M P Roberti, +47 authors, L Zitvogel. less Nat Commun, 2017 Sep 21; 8(1). PMID: 28928380 Free PMC article. Highly Cited.
Emerging Therapies for Stage III Non-Small Cell Lung Cancer: Stereotactic Body Radiation Therapy and Immunotherapy. Sameera S Kumar, Kristin A Higgins, Ronald C McGarry. Front Oncol, 2017 Sep 21; 7. PMID: 28929083 Free PMC article. Review.
Unique distribution of programmed death ligand 1 (PD-L1) expression in East Asian non-small cell lung cancer. Yunjian Pan, Difan Zheng, +11 authors, Haiquan Chen. less J Thorac Dis, 2017 Sep 22; 9(8). PMID: 28932565 Free PMC article.
Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non-Small Cell Lung Cancer. Nicholas M Mark, Julia Kargl, +7 authors, A McGarry Houghton. less Am J Respir Crit Care Med, 2017 Sep 22; 197(3). PMID: 28934595 Free PMC article.
Significance of evaluating tumor-infiltrating lymphocytes (TILs) and programmed cell death-ligand 1 (PD-L1) expression in breast cancer. Sasagu Kurozumi, Takaaki Fujii, +4 authors, Hiroyuki Kuwano. less Med Mol Morphol, 2017 Sep 25; 50(4). PMID: 28936553 Review.
PD-1/PD-L1 antibodies efficacy and safety versus docetaxel monotherapy in advanced NSCLC patients after first-line treatment option: systems assessment. Qiang Su, Zhigang Sun, +2 authors, Chenguang Zhang, Yanli Hou, Bangwei Cao. less Oncotarget, 2017 Sep 25; 8(35). PMID: 28938671 Free PMC article.
Effectiveness and safety of PD-1/PD-L1 inhibitors in the treatment of solid tumors: a systematic review and meta-analysis. Xiaohui Wang, Zhengqiang Bao, +7 authors, Songmin Ying. less Oncotarget, 2017 Sep 25; 8(35). PMID: 28938692 Free PMC article. Review.
Beyond the Percentages of PD-L1-Positive Tumor Cells: Induced Versus Constitutive PD-L1 Expression in Primary and Metastatic Head and Neck Squamous Cell Carcinoma. Theresa Scognamiglio, Yao-Tseng Chen. Head Neck Pathol, 2017 Sep 28; 12(2). PMID: 28948509 Free PMC article.
Predicting response and toxicity to immune checkpoint inhibitors using routinely available blood and clinical markers. Ashley M Hopkins, Andrew Rowland, +5 authors, Michael J Sorich. less Br J Cancer, 2017 Sep 28; 117(7). PMID: 28950287 Free PMC article. Highly Cited. Review.
Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: A systematic analysis of the literature. Rathi N Pillai, Madhusmita Behera, +6 authors, Suresh S Ramalingam. less Cancer, 2017 Sep 30; 124(2). PMID: 28960263 Free PMC article. Highly Cited. Systematic Review.
Secreted protein acidic and rich in cysteine (SPARC) induces cell migration and epithelial mesenchymal transition through WNK1/snail in non-small cell lung cancer. Jen-Yu Hung, Meng-Chi Yen, +6 authors, Po-Lin Kuo. less Oncotarget, 2017 Oct 04; 8(38). PMID: 28969021 Free PMC article.
Immunohistochemical assays incorporating SP142 and 22C3 monoclonal antibodies for detection of PD-L1 expression in NSCLC patients with known status of EGFR and ALK genes. Paweł Krawczyk, Bożena Jarosz, +8 authors, Janusz Milanowski. less Oncotarget, 2017 Oct 04; 8(38). PMID: 28969070 Free PMC article.
Hypermutated Circulating Tumor DNA: Correlation with Response to Checkpoint Inhibitor-Based Immunotherapy. Yulian Khagi, Aaron M Goodman, +5 authors, Razelle Kurzrock. less Clin Cancer Res, 2017 Oct 04; 23(19). PMID: 28972084 Free PMC article. Highly Cited.
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis. Romualdo Barroso-Sousa, William T Barry, +4 authors, Sara M Tolaney. less JAMA Oncol, 2017 Oct 04; 4(2). PMID: 28973656 Free PMC article. Highly Cited. Systematic Review.
Novel Therapies in Platinum-refractory Metastatic Germ Cell Tumor: A Case Report with a Focus on a PD-1 Inhibitor. Kah Poh Loh, Chunkit Fung. Rare Tumors, 2017 Oct 05; 9(2). PMID: 28975019 Free PMC article.
Radiomics: the bridge between medical imaging and personalized medicine. Philippe Lambin, Ralph T H Leijenaar, +17 authors, Sean Walsh. less Nat Rev Clin Oncol, 2017 Oct 05; 14(12). PMID: 28975929 Highly Cited. Review.
Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. Tao Shen, Zhengming Chen, Zhizhuang Joe Zhao, Jie Wu. Oncotarget, 2017 Oct 06; 8(37). PMID: 28977839 Free PMC article.
Differentiated tumor immune microenvironment of Epstein-Barr virus-associated and negative gastric cancer: implication in prognosis and immunotherapy. Jing Ma, Jianhui Li, +7 authors, Kaichun Wu. less Oncotarget, 2017 Oct 06; 8(40). PMID: 28978018 Free PMC article.
Increased PD-L1 expression in erlotinib-resistant NSCLC cells with MET gene amplification is reversed upon MET-TKI treatment. Christina Demuth, Morten Nørgaard Andersen, +2 authors, Boe Sandahl Sørensen. less Oncotarget, 2017 Oct 06; 8(40). PMID: 28978110 Free PMC article.
The diverse functions of the PD1 inhibitory pathway. Arlene H Sharpe, Kristen E Pauken. Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585 Highly Cited. Review.
Cholangiocarcinoma - evolving concepts and therapeutic strategies. Sumera Rizvi, Shahid A Khan, +2 authors, Gregory J Gores. less Nat Rev Clin Oncol, 2017 Oct 11; 15(2). PMID: 28994423 Free PMC article. Highly Cited. Review.
Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge", Napoli, November 30th 2016. Paolo A Ascierto, Bruno Daniele, +5 authors, Sandro Pignata. less J Transl Med, 2017 Oct 13; 15(1). PMID: 29020960 Free PMC article.
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Scott Gettinger, Jungmin Choi, +23 authors, Katerina Politi. less Cancer Discov, 2017 Oct 14; 7(12). PMID: 29025772 Free PMC article. Highly Cited.
Pneumonitis and pneumonitis-related death in cancer patients treated with programmed cell death-1 inhibitors: a systematic review and meta-analysis. Peng-Fei Cui, Jun-Xun Ma, +3 authors, Yi Hu. less Ther Clin Risk Manag, 2017 Oct 14; 13. PMID: 29026313 Free PMC article.
Safety and efficacy profile of pembrolizumab in solid cancer: pooled reanalysis based on randomized controlled trials. Manni Wang, Xuelei Ma, Linghong Guo, Fan Xia. Drug Des Devel Ther, 2017 Oct 17; 11. PMID: 29033546 Free PMC article. Review.
Genomic insights into head and neck cancer. Tim N Beck, Erica A Golemis. Cancers Head Neck, 2016 Jan 01; 1. PMID: 29034103 Free PMC article.
Expression of PD-1 and PD-L1 in poorly differentiated neuroendocrine carcinomas of the digestive system: a potential target for anti-PD-1/PD-L1 therapy. Jordan A Roberts, Raul S Gonzalez, +2 authors, Satya Das, Jordan Berlin, Chanjuan Shi. less Hum Pathol, 2017 Oct 19; 70. PMID: 29037958 Free PMC article.
Clinicopathological and prognostic significance of programmed death ligand-1 expression in breast cancer: a meta-analysis. Hye Min Kim, Jinae Lee, Ja Seung Koo. BMC Cancer, 2017 Oct 19; 17(1). PMID: 29041905 Free PMC article.
Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers. Chan-Young Ock, Jun-Eul Hwang, +12 authors, Ju-Seog Lee. less Nat Commun, 2017 Oct 21; 8(1). PMID: 29051489 Free PMC article.
PD-L1 as a biomarker in NSCLC: challenges and future directions. Matthen Mathew, Rachael A Safyan, Catherine A Shu. Ann Transl Med, 2017 Oct 24; 5(18). PMID: 29057235 Free PMC article.
Identification and Validation of a PD-L1 Binding Peptide for Determination of PDL1 Expression in Tumors. Charles Caldwell, Cory E Johnson, +3 authors, Raghuraman Kannan. less Sci Rep, 2017 Oct 24; 7(1). PMID: 29057919 Free PMC article.
[A Reflection of the New Wave of Immunotherapy on the Clinical Study of  Chinese Lung Cancer Immunotherapy]. Jingjing Liu, Shuang Zhang, Shuang Li, Ying Cheng. Zhongguo Fei Ai Za Zhi, 2017 Oct 25; 20(10). PMID: 29061217 Free PMC article. Review.
Combined immunotherapy with anti-PDL-1/PD-1 and anti-CD4 antibodies cures syngeneic disseminated neuroblastoma. Valentina Rigo, Laura Emionite, +6 authors, Michela Croce. less Sci Rep, 2017 Oct 27; 7(1). PMID: 29070883 Free PMC article.
Radiomics to predict immunotherapy-induced pneumonitis: proof of concept. Rivka R Colen, Takeo Fujii, +16 authors, Aung Naing. less Invest New Drugs, 2017 Oct 28; 36(4). PMID: 29075985 Free PMC article.
Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine. Junwei Li, Madison A Baird, +7 authors, Xiaohu Gao. less Nat Biomed Eng, 2017 Oct 31; 1. PMID: 29082104 Free PMC article.
EGFR TKI as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer. Xueli Nan, Chao Xie, Xueyan Yu, Jie Liu. Oncotarget, 2017 Nov 02; 8(43). PMID: 29088904 Free PMC article. Review.
Comparative effectiveness and safety of nab-paclitaxel plus carboplatin vs gemcitabine plus carboplatin in first-line treatment of advanced squamous cell non-small cell lung cancer in a US community oncology setting. Raja Mudad, Manish B Patel, +2 authors, Lincy S Lal. less Lung Cancer (Auckl), 2017 Nov 02; 8. PMID: 29089791 Free PMC article.
Altered miR-223 Expression in Sputum for Diagnosis of Non-Small Cell Lung Cancer. Abouzar Bagheri, Hamid Reza Khorram Khorshid, +6 authors, Mahmood Tavallaie. less Avicenna J Med Biotechnol, 2017 Nov 02; 9(4). PMID: 29090068 Free PMC article.
Immune-Related Adverse Events Associated with Anti-PD-1/PD-L1 Treatment for Malignancies: A Meta-Analysis. Peng-Fei Wang, Yang Chen, +5 authors, Chang-Xiang Yan. less Front Pharmacol, 2017 Nov 03; 8. PMID: 29093678 Free PMC article. Highly Cited.
Pembrolizumab for treatment of advanced gastric and gastroesophageal junction adenocarcinoma. Smita S Joshi, Steven B Maron, Daniel V Catenacci. Future Oncol, 2017 Nov 03; 14(5). PMID: 29094609 Free PMC article. Review.
Correlating programmed death ligand 1 (PD-L1) expression, mismatch repair deficiency, and outcomes across tumor types: implications for immunotherapy. Seung Tae Kim, Samuel J Klempner, +6 authors, Jeeyun Lee. less Oncotarget, 2017 Nov 05; 8(44). PMID: 29100397 Free PMC article.
Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives. Lidia M Yshii, Reinhard Hohlfeld, Roland S Liblau. Nat Rev Neurol, 2017 Nov 07; 13(12). PMID: 29104289 Review.
Live Cell Labeling with Terpyridine Derivative Proligands to Measure Cytotoxicity Mediated by Immune Cells. Yuki Sakai, Satoshi Mizuta, +5 authors, Yoshimasa Tanaka. less ChemMedChem, 2017 Nov 08; 12(23). PMID: 29110403 Free PMC article.
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer. Mari Mino-Kenudson. Transl Lung Cancer Res, 2017 Nov 09; 6(5). PMID: 29114473 Free PMC article. Review.
Saudi lung cancer management guidelines 2017. AR Jazieh on Behalf of Saudi Lung Cancer Guidelines Association, Saudi Lung Cancer Guidelines Members, Abdul Rahman Jazieh, +26 authors, Marie Datario. less Ann Thorac Med, 2017 Nov 10; 12(4). PMID: 29118855 Free PMC article.
PD-L1 Testing in Guiding Patient Selection for PD-1/PD-L1 Inhibitor Therapy in Lung Cancer. Katerina Ancevski Hunter, Mark A Socinski, Liza C Villaruz. Mol Diagn Ther, 2017 Nov 10; 22(1). PMID: 29119407 Free PMC article. Review.
Combining DNA damaging therapeutics with immunotherapy: more haste, less speed. Jessica S Brown, Raghav Sundar, Juanita Lopez. Br J Cancer, 2017 Nov 11; 118(3). PMID: 29123260 Free PMC article. Highly Cited. Review.
Evaluating the cost-effectiveness of afatinib after platinum-based therapy for the treatment of squamous non-small-cell lung cancer in France. Maud Pignata, Christos Chouaid, +4 authors, Stéphane Roze. less Clinicoecon Outcomes Res, 2017 Nov 11; 9. PMID: 29123418 Free PMC article.
Incidence of immune checkpoint inhibitor-related colitis in solid tumor patients: A systematic review and meta-analysis. Daniel Y Wang, Fei Ye, Shilin Zhao, Douglas B Johnson. Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123955 Free PMC article.
Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade. Haoran Zha, Xiao Han, +5 authors, Bo Zhu. less Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123963 Free PMC article.
Immunotherapy "Shock" with vitiligo due to nivolumab administration as third line therapy in lung adenocarcinoma. Paul Zarogoulidis, Haidong Huang, +11 authors, Wolfgang Hohenforst-Schmidt. less Respir Med Case Rep, 2017 Nov 11; 22. PMID: 29124007 Free PMC article.
Non-small cell lung cancer clinical trials requiring biopsies with biomarker-specific results for enrollment provide unique challenges. Marshall L Spiegel, Jonathan W Goldman, +24 authors, Edward B Garon. less Cancer, 2017 Nov 11; 123(24). PMID: 29125624 Free PMC article. Review.
Prognostic significance of PD-L1 expression and tumor infiltrating lymphocyte in surgically resectable non-small cell lung cancer. Gen Lin, Xirong Fan, +9 authors, Chao Li. less Oncotarget, 2017 Nov 16; 8(48). PMID: 29137398 Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer. R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs. Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554 Free PMC article. Review.
Immune checkpoint inhibitor colitis: the flip side of the wonder drugs. Naziheh Assarzadegan, Elizabeth Montgomery, Robert A Anders. Virchows Arch, 2017 Nov 17; 472(1). PMID: 29143108 Review.
Cure in Advanced Renal Cell Cancer: Is It an Achievable Goal? Dhanusha Sabanathan, John J Park, +3 authors, Howard Gurney. less Oncologist, 2017 Nov 18; 22(12). PMID: 29146617 Free PMC article.
Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. Minan Wang, Li-Chin Yao, +14 authors, James G Keck. less FASEB J, 2017 Nov 18; 32(3). PMID: 29146734 Free PMC article. Highly Cited.
Host immune response index in gastric cancer identified by comprehensive analyses of tumor immunity. Charny Park, Junhun Cho, +15 authors, Kyoung-Mee Kim. less Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147610 Free PMC article.
Trial Watch: Adoptively transferred cells for anticancer immunotherapy. Carole Fournier, François Martin, +3 authors, Lionel Apetoh. less Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147628 Free PMC article. Review.
Trial watch: Immune checkpoint blockers for cancer therapy. Claire Vanpouille-Box, Claire Lhuillier, +10 authors, Lorenzo Galluzzi. less Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147629 Free PMC article. Highly Cited. Review.
Prognostic relevance of programmed cell death ligand 1 expression in glioblastoma. Kyu Sang Lee, Kyoungyul Lee, +6 authors, Gheeyoung Choe. less J Neurooncol, 2017 Nov 18; 136(3). PMID: 29147863
The role of weekly nanoparticle albumin bound paclitaxel monotherapy as second line or later treatment for advanced NSCLC in China. Puyuan Xing, Yixiang Zhu, +3 authors, Ling Shan, Sipeng Chen, Xuezhi Hao, Junling Li. less Oncotarget, 2017 Nov 21; 8(50). PMID: 29152093 Free PMC article.
2015 Review of Newly Approved Oncologic Therapies. Patrick Medina, Monique Giordana. J Adv Pract Oncol, 2016 Apr 01; 7(3). PMID: 29152387 Free PMC article. Review.
Immunotherapy and the Treatment of Non-Small Cell Lung Cancer. Suzanne Walker. J Adv Pract Oncol, 2016 Apr 01; 7(3). PMID: 29152394 Free PMC article. Review.
Safety in treatment of hepatocellular carcinoma with immune checkpoint inhibitors as compared to melanoma and non-small cell lung cancer. Zachary J Brown, Bernd Heinrich, +2 authors, Seth M Steinberg, Su Jong Yu, Tim F Greten. less J Immunother Cancer, 2017 Nov 22; 5(1). PMID: 29157287 Free PMC article.
PD-L1 is a Prognostic Biomarker in Resected NSCLC Patients with Moderate/high Smoking History and Elevated Serum SCCA Level. Lianjing Cao, Xinyue Wang, +5 authors, Richeng Jiang. less J Cancer, 2017 Nov 22; 8(16). PMID: 29158797 Free PMC article.
Incidence of immune-related adverse events and its association with treatment outcomes: the MD Anderson Cancer Center experience. Takeo Fujii, Rivka R Colen, +19 authors, Aung Naing. less Invest New Drugs, 2017 Nov 22; 36(4). PMID: 29159766 Free PMC article.
PD-L1 expression and CD8+ tumor-infiltrating lymphocytes are associated with ALK rearrangement and clinicopathological features in inflammatory myofibroblastic tumors. Yoon Jin Cha, Hyo Sup Shim. Oncotarget, 2017 Nov 23; 8(52). PMID: 29163763 Free PMC article.
PD-L1 expression heterogeneity in non-small cell lung cancer: evaluation of small biopsies reliability. Enrico Munari, Giuseppe Zamboni, +15 authors, Giuseppe Bogina. less Oncotarget, 2017 Nov 23; 8(52). PMID: 29163815 Free PMC article.
Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab. Fei Zhang, Xiaoqiang Qi, +9 authors, Ying Zheng. less Oncotarget, 2017 Nov 23; 8(52). PMID: 29163822 Free PMC article.
Prognostic value of PD-L1 expression in combination with CD8+ TILs density in patients with surgically resected non-small cell lung cancer. Hui Yang, Jinpeng Shi, +11 authors, Caicun Zhou. less Cancer Med, 2017 Nov 24; 7(1). PMID: 29168339 Free PMC article.
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. Hiro Sato, Atsuko Niimi, +14 authors, Atsushi Shibata. less Nat Commun, 2017 Nov 25; 8(1). PMID: 29170499 Free PMC article. Highly Cited.
Evolution of early phase clinical trials in oncology. Nam Q Bui, Shivaani Kummar. J Mol Med (Berl), 2017 Nov 28; 96(1). PMID: 29177698 Review.
Optimizing peptide epitope-based autoantibody detection in cancer patients. Maize Wang, Shirley H Lomeli, +3 authors, Gang Zeng. less Am J Clin Exp Immunol, 2017 Nov 29; 6(5). PMID: 29181273 Free PMC article.
CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells. Meagan R Rollins, Rachel M Gibbons Johnson. J Immunol Res, 2017 Nov 29; 2017. PMID: 29181416 Free PMC article.
Programmed cell death ligand 1 protein levels predicted survival of non-small cell lung cancer. Shaohua Cui, Xinying Su, +9 authors, Liyan Jiang. less J Cancer, 2017 Dec 01; 8(19). PMID: 29187883 Free PMC article.
Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. Wei Wu, Franziska Haderk, Trever G Bivona. Cancers (Basel), 2017 Dec 01; 9(12). PMID: 29189709 Free PMC article. Review.
Enhancement of the anti-tumor activity of FGFR1 inhibition in squamous cell lung cancer by targeting downstream signaling involved in glucose metabolism. Claudia Fumarola, Daniele Cretella, +14 authors, Andrea Ardizzoni. less Oncotarget, 2017 Dec 02; 8(54). PMID: 29190880 Free PMC article.
Implications of the tumor immune microenvironment for staging and therapeutics. Janis M Taube, Jérôme Galon, +8 authors, Ashley Cimino-Mathews. less Mod Pathol, 2017 Dec 02; 31(2). PMID: 29192647 Free PMC article. Highly Cited. Review.
Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer. Michael J Topper, Michelle Vaz, +15 authors, Stephen B Baylin. less Cell, 2017 Dec 02; 171(6). PMID: 29195073 Free PMC article. Highly Cited.
Spatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non-Small Cell Lung Cancer. Franz Villarroel-Espindola, Xiaoqing Yu, +9 authors, Kurt A Schalper. less Clin Cancer Res, 2017 Dec 06; 24(7). PMID: 29203588 Free PMC article.
QuPath: Open source software for digital pathology image analysis. Peter Bankhead, Maurice B Loughrey, +10 authors, Peter W Hamilton. less Sci Rep, 2017 Dec 06; 7(1). PMID: 29203879 Free PMC article. Highly Cited.
A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. Fei Tang, Peng Zhang, +10 authors, Pan Zheng. less Elife, 2017 Dec 06; 6. PMID: 29206103 Free PMC article.
Recurrent glioma clinical trial, CheckMate-143: the game is not over yet. Anna C Filley, Mario Henriquez, Mahua Dey. Oncotarget, 2017 Dec 07; 8(53). PMID: 29207684 Free PMC article. Highly Cited. Review.
Multiplex three-dimensional optical mapping of tumor immune microenvironment. Steve Seung-Young Lee, Vytautas P Bindokas, Stephen J Kron. Sci Rep, 2017 Dec 07; 7(1). PMID: 29208908 Free PMC article.
Immune checkpoint inhibitors for advanced non-small cell lung cancer: emerging sequencing for new treatment targets. Pedro Nazareth Aguiar, Ramon Andrade De Mello, +4 authors, Gilberto de Lima Lopes. less ESMO Open, 2017 Dec 07; 2(3). PMID: 29209522 Free PMC article. Review.
Pembrolizumab as second-line therapy in non-small cell lung cancer in northern Norway: budget impact and expected gain-a model-based analysis. Jan Norum, Margareth Aarag Antonsen, +4 authors, Nina Helbekkmo. less ESMO Open, 2017 Dec 07; 2(3). PMID: 29209527 Free PMC article.
Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics. Abhishek D Garg, Sanket More, +6 authors, Lorenzo Galluzzi. less Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209573 Free PMC article. Highly Cited. Review.
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors. Yingyan Yu. Front Med, 2017 Dec 07; 12(2). PMID: 29209918
Radiotherapy: the key to immunotherapy ignition? Elaine Luterstein, Narek Shaverdian, Percy Lee. Oncotarget, 2017 Dec 08; 8(55). PMID: 29212146 Free PMC article.
Quantitative Biomarkers for Prediction of Epidermal Growth Factor Receptor Mutation in Non-Small Cell Lung Cancer. Liwen Zhang, Bojiang Chen, +6 authors, Jie Tian. less Transl Oncol, 2017 Dec 08; 11(1). PMID: 29216508 Free PMC article.
Moving more potent and less toxic options to the frontline in the management of advanced lung cancer. Xiuning Le, Deepa Rangachari, Daniel B Costa. J Thorac Dis, 2017 Dec 10; 9(9). PMID: 29221246 Free PMC article.
Non-small cell lung cancer treatment (r)evolution: ten years of advances and more to come. Luca Toschi, Sabrina Rossi, Giovanna Finocchiaro, Armando Santoro. Ecancermedicalscience, 2017 Dec 12; 11. PMID: 29225694 Free PMC article. Review.
Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer. Xinxin Zhu, Jinghe Lang. Oncotarget, 2017 Dec 13; 8(57). PMID: 29228642 Free PMC article. Highly Cited. Review.
Changes in programmed death-ligand 1 expression during cisplatin treatment in patients with head and neck squamous cell carcinoma. Chan-Young Ock, Sehui Kim, +12 authors, Dae Seog Heo. less Oncotarget, 2017 Dec 13; 8(58). PMID: 29228662 Free PMC article.
PD-L1 immunohistochemical assays for assessment of therapeutic strategies involving immune checkpoint inhibitors in non-small cell lung cancer: a comparative study. Hyojin Kim, Hyun Jung Kwon, +2 authors, Soo Young Park, Eunhyang Park, Jin-Haeng Chung. less Oncotarget, 2017 Dec 13; 8(58). PMID: 29228707 Free PMC article.
Investigational PD-1 inhibitors in HL and NHL and biomarkers for predictors of response and outcome. Andres Chang, Danielle Schlafer, Christopher R Flowers, Pamela B Allen. Expert Opin Investig Drugs, 2017 Dec 13; 27(1). PMID: 29228840 Free PMC article. Review.
The Role of Checkpoint Inhibition in Non-Small Cell Lung Cancer. Jonathan Lu, Robert A Ramirez. Ochsner J, 2017 Dec 13; 17(4). PMID: 29230122 Free PMC article. Review.
Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract. Michael Dougan. Front Immunol, 2017 Dec 13; 8. PMID: 29230210 Free PMC article. Highly Cited. Review.
Feasibility and Safety of Intrathoracic Biopsy and Repeat Biopsy for Evaluation of Programmed Cell Death Ligand-1 Expression for Immunotherapy in Non-Small Cell Lung Cancer. Emily B Tsai, Kelsey Pomykala, +11 authors, Robert Suh. less Radiology, 2017 Dec 13; 287(1). PMID: 29232184 Free PMC article.
Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. Mark Lawler, Deborah Alsina, +19 authors, Bowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative. less Gut, 2017 Dec 14; 67(1). PMID: 29233930 Free PMC article. Review.
Molecular Biomarkers of Primary and Acquired Resistance to T-Cell-Mediated Immunotherapy in Cancer: Landscape, Clinical Implications, and Future Directions. Young Kwang Chae, Michael S Oh, Francis J Giles. Oncologist, 2017 Dec 16; 23(4). PMID: 29242279 Free PMC article. Review.
Challenges and future of biomarker tests in the era of precision oncology: Can we rely on immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to select the optimal patients for matched therapy? Young Kwang Chae, Ayush Arya, +9 authors, Francis Giles. less Oncotarget, 2017 Dec 17; 8(59). PMID: 29246028 Free PMC article. Review.
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA. Matthew A Coelho, Sophie de Carné Trécesson, +11 authors, Julian Downward. less Immunity, 2017 Dec 17; 47(6). PMID: 29246442 Free PMC article. Highly Cited.
The Most Recent Oncologic Emergency: What Emergency Physicians Need to Know About the Potential Complications of Immune Checkpoint Inhibitors. Duncan Simmons, Eddy Lang. Cureus, 2017 Dec 19; 9(10). PMID: 29250474 Free PMC article. Review.
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response? Zijun Y Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H Young. Front Immunol, 2017 Dec 20; 8. PMID: 29255458 Free PMC article. Highly Cited. Review.
A pilot study of an autologous tumor-derived autophagosome vaccine with docetaxel in patients with stage IV non-small cell lung cancer. Rachel E Sanborn, Helen J Ross, +12 authors, Bernard A Fox. less J Immunother Cancer, 2017 Dec 21; 5(1). PMID: 29258618 Free PMC article.
Understanding preanalytical variables and their effects on clinical biomarkers of oncology and immunotherapy. Lokesh Agrawal, Kelly B Engel, Sarah R Greytak, Helen M Moore. Semin Cancer Biol, 2017 Dec 21; 52(Pt 2). PMID: 29258857 Free PMC article. Review.
Predictive clinical parameters for the response of nivolumab in pretreated advanced non-small-cell lung cancer. Yuko Oya, Tatsuya Yoshida, +7 authors, Yasushi Yatabe. less Oncotarget, 2017 Dec 22; 8(61). PMID: 29262550 Free PMC article.
A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity. Hongwei Tian, Gang Shi, +12 authors, Hongxin Deng. less Signal Transduct Target Ther, 2017 Dec 22; 1. PMID: 29263903 Free PMC article.
Clinical and Molecular Characteristics Associated With Survival Among Patients Treated With Checkpoint Inhibitors for Advanced Non-Small Cell Lung Carcinoma: A Systematic Review and Meta-analysis. Chee Khoon Lee, Johnathan Man, +7 authors, James Chih-Hsin Yang. less JAMA Oncol, 2017 Dec 23; 4(2). PMID: 29270615 Free PMC article. Highly Cited. Systematic Review.
The Positive Relationship Between γH2AX and PD-L1 Expression in Lung Squamous Cell Carcinoma. Atsushi Osoegawa, Hitomi Hiraishi, +6 authors, Kenji Sugio. less In Vivo, 2017 Dec 25; 32(1). PMID: 29275316 Free PMC article.
Live, Learn, Pass It on: A Patient Advocacy Engagement Project on the Lived Experience of Lung Cancer Survivors. Sydney M Dy, Ellen M Janssen, Andrea Ferris, John Fp Bridges. J Patient Exp, 2017 Dec 26; 4(4). PMID: 29276762 Free PMC article.
How Checkpoint Inhibitors Are Changing the Treatment Paradigm in Solid Tumors: What Advanced Practitioners in Oncology Need to Know. Marianne Davies. J Adv Pract Oncol, 2016 Jul 01; 7(5). PMID: 29282426 Free PMC article. Review.
Biomarkers/Molecular Targets, Immunotherapy, and Treatments for Non-Small Cell Lung Cancer. Elizabeth S Waxman, Frank V Fossella. J Adv Pract Oncol, 2016 Jul 01; 7(5). PMID: 29282427 Free PMC article. Review.
Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma. Bert H O'Neil, John M Wallmark, +14 authors, Sae-Won Han. less PLoS One, 2017 Dec 29; 12(12). PMID: 29284010 Free PMC article. Highly Cited.
Pembrolizumab in Asia-Pacific patients with advanced head and neck squamous cell carcinoma: Analyses from KEYNOTE-012. Makoto Tahara, Kei Muro, +6 authors, Yung-Jue Bang. less Cancer Sci, 2017 Dec 29; 109(3). PMID: 29284202 Free PMC article.
Classifying Non-Small Cell Lung Cancer by Status of Programmed Cell Death Ligand 1 and Tumor-Infiltrating Lymphocytes on Tumor Cells. Shaohua Cui, Lili Dong, +2 authors, Jialin Qian, Lin Ye, Liyan Jiang. less J Cancer, 2018 Jan 02; 9(1). PMID: 29290777 Free PMC article.
Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy. Xiang Yan, Li Wang, +11 authors, Bingliang Fang. less Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296537 Free PMC article.
Evaluation of rare but severe immune related adverse effects in PD-1 and PD-L1 inhibitors in non-small cell lung cancer: a meta-analysis. Yang-Bo Hu, Qun Zhang, +6 authors, written on behalf of the AME Academic Lung Cancer Cooperation Group. less Transl Lung Cancer Res, 2018 Jan 05; 6(Suppl 1). PMID: 29299404 Free PMC article.
Epidermal growth factor tyrosine kinase inhibitor therapy inferior to second-line chemotherapy in EGFR wild-type non-small cell lung cancer patients: results of French nationwide observational study. Aaron Lisberg, Edward B Garon. Transl Lung Cancer Res, 2018 Jan 05; 6(Suppl 1). PMID: 29299407 Free PMC article.
Avelumab: another active immune checkpoint inhibitor in non-small cell lung cancer. Hao Xie, Alex A Adjei. Transl Lung Cancer Res, 2018 Jan 05; 6(Suppl 1). PMID: 29299408 Free PMC article.
Reproducibility of PD-L1 assessment in non-small cell lung cancer-know your limits but never stop trying to exceed them. Marius Ilie, Paul Hofman. Transl Lung Cancer Res, 2018 Jan 05; 6(Suppl 1). PMID: 29299411 Free PMC article.
Pembrolizumab in advanced pretreated small cell lung cancer patients with PD-L1 expression: data from the KEYNOTE-028 trial: a reason for hope? Alejandro Navarro, Enriqueta Felip. Transl Lung Cancer Res, 2018 Jan 05; 6(Suppl 1). PMID: 29299418 Free PMC article.
Immunotherapy for Non-small-cell Lung Cancer: Current Status and Future Obstacles. Ju Hwan Cho. Immune Netw, 2018 Jan 06; 17(6). PMID: 29302251 Free PMC article. Review.
PD-1 related transcriptome profile and clinical outcome in diffuse gliomas. Shuai Liu, Zheng Wang, +5 authors, Tao Jiang. less Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308304 Free PMC article.
Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: Rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy. Emily Z Keung, Jen-Wei Tsai, +10 authors, Christina L Roland. less Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308306 Free PMC article.
Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies. Marie Kostine, Inge H Briaire-de Bruijn, +9 authors, Judith V M G Bovée. less Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308311 Free PMC article.
Risk of gastrointestinal toxicities with PD-1 inhibitors in cancer patients: A meta-analysis of randomized clinical trials. Wei Wei, Zhibin Luo. Medicine (Baltimore), 2018 Jan 10; 96(48). PMID: 29310385 Free PMC article.
Optimal pembrolizumab dosing for non-small cell lung cancer: further studies still needed. Hai-Yan Tu, Qi Zhang, Yi-Long Wu. J Thorac Dis, 2018 Jan 10; 9(12). PMID: 29312666 Free PMC article.
Characteristics of Real-World Metastatic Non-Small Cell Lung Cancer Patients Treated with Nivolumab and Pembrolizumab During the Year Following Approval. Sean Khozin, Amy P Abernethy, +11 authors, Richard Pazdur. less Oncologist, 2018 Jan 11; 23(3). PMID: 29317551 Free PMC article.
Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non-Small Cell Lung Cancer. Laura Mezquita, Edouard Auclin, +19 authors, Benjamin Besse. less JAMA Oncol, 2018 Jan 13; 4(3). PMID: 29327044 Free PMC article. Highly Cited.
Tumor Immunology and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer. Chi Young Jung, Scott J Antonia. Tuberc Respir Dis (Seoul), 2018 Jan 15; 81(1). PMID: 29332322 Free PMC article. Review.
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression. Heng Lin, Shuang Wei, +16 authors, Weiping Zou. less J Clin Invest, 2018 Jan 18; 128(2). PMID: 29337305 Free PMC article. Highly Cited.
Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression. Dewan Md Sakib Hossain, Sarah Javaid, +8 authors, Alissa Chackerian. less J Clin Invest, 2018 Jan 18; 128(2). PMID: 29337311 Free PMC article.
Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing. Hira Rizvi, Francisco Sanchez-Vega, +29 authors, Matthew D Hellmann. less J Clin Oncol, 2018 Jan 18; 36(7). PMID: 29337640 Free PMC article. Highly Cited.
CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy. Gwendolyn J McGinnis, Jacob Raber. Immunotherapy, 2018 Jan 18; 9(11). PMID: 29338610 Free PMC article. Review.
Clinical significance of YAP1 activation in head and neck squamous cell carcinoma. Young-Gyu Eun, Dongjin Lee, +5 authors, Ju-Seog Lee. less Oncotarget, 2018 Jan 18; 8(67). PMID: 29340043 Free PMC article.
AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer. Hong Zhu, Lin-Lin Chang, +8 authors, Bo Yang. less Theranostics, 2018 Jan 19; 8(3). PMID: 29344298 Free PMC article.
TPF induction chemotherapy increases PD-L1 expression in tumour cells and immune cells in head and neck squamous cell carcinoma. Charlotte Leduc, Julien Adam, +15 authors, Sophie Postel-Vinay. less ESMO Open, 2018 Jan 19; 3(1). PMID: 29344407 Free PMC article.
Checkpoint Inhibitors, Palliative Care, or Hospice. Mellar P Davis, Rajiv Panikkar. Curr Oncol Rep, 2018 Jan 20; 20(1). PMID: 29349518 Review.
Hypermutated Tumors and Immune Checkpoint Inhibition. Kristen K Ciombor, Richard M Goldberg. Drugs, 2018 Jan 20; 78(2). PMID: 29350327 Review.
The differences in the assessments of side effects at an oncology outpatient clinic. A Bayraktar-Ekincioglu, E Kucuk. Int J Clin Pharm, 2018 Jan 22; 40(2). PMID: 29353396
Do we have biomarkers to predict response to neoadjuvant and adjuvant chemotherapy and immunotherapy in bladder cancer? Felix Wezel, Stefan Vallo, Florian Roghmann, Young Academic Urologist Urothelial Carcinoma Group of the European Association of Urology. Transl Androl Urol, 2018 Jan 23; 6(6). PMID: 29354494 Free PMC article. Review.
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations. Jun Gong, Alexander Chehrazi-Raffle, Srikanth Reddi, Ravi Salgia. J Immunother Cancer, 2018 Jan 24; 6(1). PMID: 29357948 Free PMC article. Highly Cited. Review.
PD-1/PD-L1 Axis in Lung Cancer. Fernando C Santini, Matthew D Hellmann. Cancer J, 2018 Jan 24; 24(1). PMID: 29360723 Free PMC article. Review.
Mechanisms of Resistance to PD-1 and PD-L1 Blockade. Theodore S Nowicki, Siwen Hu-Lieskovan, Antoni Ribas. Cancer J, 2018 Jan 24; 24(1). PMID: 29360728 Free PMC article. Highly Cited. Review.
Colorectal Cancers: An Update on Their Molecular Pathology. Kentaro Inamura. Cancers (Basel), 2018 Jan 25; 10(1). PMID: 29361689 Free PMC article. Highly Cited. Review.
The biology and management of non-small cell lung cancer. Roy S Herbst, Daniel Morgensztern, Chris Boshoff. Nature, 2018 Jan 25; 553(7689). PMID: 29364287 Highly Cited. Review.
Predictive and prognostic clinical and pathological factors of nivolumab efficacy in non-small-cell lung cancer patients. J Garde-Noguera, P Martin-Martorell, +16 authors, O Juan-Vidal. less Clin Transl Oncol, 2018 Jan 26; 20(8). PMID: 29368144
The ascent of immune checkpoint inhibitors: is the understudy ready for a leading role? Amy L Cummings, Edward B Garon. Cancer Biol Med, 2018 Jan 27; 14(4). PMID: 29372100 Free PMC article.
Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1-Negative Human Lung Cancers. Haiying Cheng, Alain Borczuk, +6 authors, Xingxing Zang. less Clin Cancer Res, 2018 Jan 28; 24(8). PMID: 29374053 Free PMC article.
Treatment-Related Adverse Events Predict Improved Clinical Outcome in NSCLC Patients on KEYNOTE-001 at a Single Center. Aaron Lisberg, D Andrew Tucker, +23 authors, Edward B Garon. less Cancer Immunol Res, 2018 Feb 01; 6(3). PMID: 29382669 Free PMC article.
Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients. Niki Karachaliou, Maria Gonzalez-Cao, +15 authors, Rafael Rosell. less Ther Adv Med Oncol, 2018 Feb 01; 10. PMID: 29383037 Free PMC article. Highly Cited.
Diverse cutaneous adverse eruptions caused by anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies: clinical features and management. John Shen, Jason Chang, +3 authors, Rajan P Kulkarni. less Ther Adv Med Oncol, 2018 Feb 01; 10. PMID: 29383039 Free PMC article.
Role of immune-checkpoint inhibitors in lung cancer. Prantesh Jain, Chhavi Jain, Vamsidhar Velcheti. Ther Adv Respir Dis, 2018 Feb 02; 12. PMID: 29385894 Free PMC article. Review.
Activity of pembrolizumab in relapsed/refractory NK/T-cell lymphoma. Xin Li, Yasong Cheng, +15 authors, Ken H Young. less J Hematol Oncol, 2018 Feb 02; 11(1). PMID: 29386072 Free PMC article. Highly Cited.
Development of an Immune-Pathology Informed Radiomics Model for Non-Small Cell Lung Cancer. Chad Tang, Brian Hobbs, +13 authors, Eugene J Koay. less Sci Rep, 2018 Feb 02; 8(1). PMID: 29386574 Free PMC article.
The role of tumor-infiltrating lymphocytes (TILs) as a predictive biomarker of response to anti-PD1 therapy in patients with metastatic non-small cell lung cancer or metastatic melanoma. Anton Uryvaev, Maria Passhak, +2 authors, Dov Hershkovits, Edmond Sabo, Gil Bar-Sela. less Med Oncol, 2018 Feb 02; 35(3). PMID: 29388007
Neurological Adverse Events Associated with Immune Checkpoint Inhibitors: Diagnosis and Management. Christophoros Astaras, Rita de Micheli, +2 authors, Bianca Moura, Thomas Hundsberger, Andreas F Hottinger. less Curr Neurol Neurosci Rep, 2018 Feb 03; 18(1). PMID: 29392441 Review.
PD-1 (PDCD1) Promoter Methylation Is a Prognostic Factor in Patients With Diffuse Lower-Grade Gliomas Harboring Isocitrate Dehydrogenase (IDH) Mutations. Lea Kristin Röver, Heidrun Gevensleben, +4 authors, Dimo Dietrich. less EBioMedicine, 2018 Feb 06; 28. PMID: 29396294 Free PMC article.
Dendritic cell vaccine induces antigen-specific CD8+ T cells that are metabolically distinct from those of peptide vaccine and is well-combined with PD-1 checkpoint blockade. Koji Nagaoka, Akihiro Hosoi, +3 authors, Kazuhiro Kakimi. less Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399391 Free PMC article.
Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines. Edmund K Moon, Liang-Chuan S Wang, +4 authors, Steven M Albelda. less Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399394 Free PMC article.
Immune Checkpoint Inhibitors in Advanced-Stage Non-small Cell Lung Cancer. Seher Nazlı Kazaz, İlhan Öztop. Turk Thorac J, 2018 Feb 07; 18(4). PMID: 29404172 Free PMC article. Review.
Evaluation of PD-L1 expression on vortex-isolated circulating tumor cells in metastatic lung cancer. Manjima Dhar, Jessica Wong, +8 authors, Rajan P Kulkarni. less Sci Rep, 2018 Feb 09; 8(1). PMID: 29416054 Free PMC article.
Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma. Izak Faiena, Amy L Cummings, +3 authors, Alexandra Drakaki. less Drug Des Devel Ther, 2018 Feb 09; 12. PMID: 29416316 Free PMC article. Review.
Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer. Olivier Belzile, Xianming Huang, +4 authors, Bruce D Freimark. less Immunotargets Ther, 2018 Feb 09; 7. PMID: 29417044 Free PMC article. Review.
PD-L1 diagnostic tests: a systematic literature review of scoring algorithms and test-validation metrics. Margarita Udall, Maria Rizzo, +4 authors, Eric Faulkner. less Diagn Pathol, 2018 Feb 11; 13(1). PMID: 29426340 Free PMC article. Highly Cited. Systematic Review.
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Immune checkpoint inhibitors, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors). G Redelman-Sidi, O Michielin, +4 authors, O Manuel. less Clin Microbiol Infect, 2018 Feb 11; 24 Suppl 2. PMID: 29427804 Free PMC article. Review.
Targeted drugs for systemic therapy of lung cancer with brain metastases. Ya-Wen Sun, Jian Xu, Jun Zhou, Wen-Juan Liu. Oncotarget, 2018 Feb 13; 9(4). PMID: 29435193 Free PMC article. Review.
Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer. Motonobu Saito, Katsuharu Saito, +6 authors, Akiteru Goto. less Mol Clin Oncol, 2018 Feb 13; 8(2). PMID: 29435295 Free PMC article.
Novel active agents in patients with advanced NSCLC without driver mutations who have progressed after first-line chemotherapy. Christian Manegold, Alex Adjei, +19 authors, Caicun Zhou. less ESMO Open, 2018 Feb 13; 1(6). PMID: 29435365 Free PMC article.
Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients. Ari Vanderwalde, David Spetzler, +2 authors, Nianqing Xiao, Zoran Gatalica, John Marshall. less Cancer Med, 2018 Feb 13; 7(3). PMID: 29436178 Free PMC article. Highly Cited.
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma. Karolina Woroniecka, Pakawat Chongsathidkiet, +19 authors, Peter E Fecci. less Clin Cancer Res, 2018 Feb 14; 24(17). PMID: 29437767 Free PMC article. Highly Cited.
Axitinib in combination with pembrolizumab in patients with advanced renal cell cancer: a non-randomised, open-label, dose-finding, and dose-expansion phase 1b trial. Michael B Atkins, Elizabeth R Plimack, +11 authors, Toni K Choueiri. less Lancet Oncol, 2018 Feb 15; 19(3). PMID: 29439857 Free PMC article. Highly Cited.
Immune Checkpoint Blockade: The New Frontier in Cancer Treatment. Jeffrey M Clarke, Daniel J George, Stacey Lisi, April K S Salama. Target Oncol, 2018 Feb 15; 13(1). PMID: 29441437
Immunohistochemical analysis and prognostic significance of PD-L1, PD-1, and CD8+ tumor-infiltrating lymphocytes in Ewing's sarcoma family of tumors (ESFT). Isidro Machado, Jose Antonio López-Guerrero, +2 authors, Katia Scotlandi, Piero Picci, Antonio Llombart-Bosch. less Virchows Arch, 2018 Feb 16; 472(5). PMID: 29445891
Temozolomide-associated hypermutation in gliomas. Serah Choi, Yao Yu, +3 authors, Joseph F Costello. less Neuro Oncol, 2018 Feb 17; 20(10). PMID: 29452419 Free PMC article. Highly Cited. Review.
Analysis of middle- and long-term efficacy of thoracoscope-assisted segmental resection of the lung on non-small cell lung cancer in the early stage. Ning Ding, Ning Zhou, +2 authors, Qinglin Li, Guangming Ren, Min Zhou. less Oncol Lett, 2018 Feb 20; 15(3). PMID: 29456731 Free PMC article.
Clinical and molecular characteristics of pulmonary sarcomatoid carcinoma. Jae Kyeom Sim, Sang Mi Chung, +10 authors, Sung Yong Lee. less Korean J Intern Med, 2018 Feb 21; 33(4). PMID: 29458244 Free PMC article.
The Significance of MMP-1 in EGFR-TKI-Resistant Lung Adenocarcinoma: Potential for Therapeutic Targeting. Ryoko Saito, Yasuhiro Miki, +6 authors, Hironobu Sasano. less Int J Mol Sci, 2018 Feb 22; 19(2). PMID: 29463039 Free PMC article.
The impact of PD-L1 on survival and value of the immune check point inhibitors in non-small-cell lung cancer; proposal, policies and perspective. Helmy M Guirgis. J Immunother Cancer, 2018 Feb 22; 6(1). PMID: 29463302 Free PMC article.
Implications of KRAS mutations in acquired resistance to treatment in NSCLC. Marzia Del Re, Eleonora Rofi, +6 authors, Romano Danesi. less Oncotarget, 2018 Feb 22; 9(5). PMID: 29464099 Free PMC article. Review.
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Alessandro Prestipino, Alica J Emhardt, +46 authors, Robert Zeiser. less Sci Transl Med, 2018 Feb 23; 10(429). PMID: 29467301 Free PMC article. Highly Cited.
A comparative study of PD-L1 immunohistochemical assays with four reliable antibodies in thymic carcinoma. Tadashi Sakane, Takayuki Murase, +11 authors, Hiroshi Inagaki. less Oncotarget, 2018 Feb 23; 9(6). PMID: 29467945 Free PMC article.
Safety profile of avelumab in patients with advanced solid tumors: A pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials. Karen Kelly, Jeffrey R Infante, +8 authors, James L Gulley. less Cancer, 2018 Feb 23; 124(9). PMID: 29469949 Free PMC article.
Metastatic site as a predictor of nivolumab efficacy in patients with advanced non-small cell lung cancer: A retrospective multicenter trial. Motohiro Tamiya, Akihiro Tamiya, +12 authors, Fumio Imamura. less PLoS One, 2018 Feb 23; 13(2). PMID: 29470536 Free PMC article. Highly Cited.
Sustained Persistence of IL2 Signaling Enhances the Antitumor Effect of Peptide Vaccines through T-cell Expansion and Preventing PD-1 Inhibition. Hussein Sultan, Takumi Kumai, +6 authors, Esteban Celis. less Cancer Immunol Res, 2018 Feb 28; 6(5). PMID: 29483127 Free PMC article.
Unique Immune Gene Expression Patterns in Bronchoalveolar Lavage and Tumor Adjacent Non-Neoplastic Lung Tissue in Non-Small Cell Lung Cancer. Chih-Hsi Scott Kuo, Chien-Ying Liu, +11 authors, Cheng-Ta Yang. less Front Immunol, 2018 Feb 28; 9. PMID: 29483918 Free PMC article.
Anti-PD-1/PD-L1 antibodies versus docetaxel in patients with previously treated non-small-cell lung cancer. Qi Jiang, Mixue Xie, +3 authors, Sufen Yu. less Oncotarget, 2018 Feb 28; 9(7). PMID: 29484143 Free PMC article.
Systemic immune-inflammation index in germ-cell tumours. Michal Chovanec, Zuzana Cierna, +11 authors, Jozef Mardiak. less Br J Cancer, 2018 Feb 28; 118(6). PMID: 29485980 Free PMC article.
Immune checkpoint inhibitor (nivolumab)-associated kidney injury and the importance of recognizing concomitant medications known to cause acute tubulointerstitial nephritis: a case report. Ryo Koda, Hirofumi Watanabe, +5 authors, Ichiei Narita. less BMC Nephrol, 2018 Mar 01; 19(1). PMID: 29486725 Free PMC article.
Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma. Young Kwang Chae, Jonathan F Anker, +3 authors, Jeffrey H Chuang. less Oncotarget, 2018 Mar 01; 9(8). PMID: 29487705 Free PMC article.
Immune Monitoring of Cancer Patients Prior to and During CTLA-4 or PD-1/PD-L1 Inhibitor Treatment. Antje Tunger, Maximilian Kießler, +4 authors, Marc Schmitz. less Biomedicines, 2018 Mar 02; 6(1). PMID: 29494517 Free PMC article. Review.
Tumor Resistance against ALK Targeted Therapy-Where It Comes From and Where It Goes. Geeta Geeta Sharma, Ines Mota, +3 authors, Roberto Chiarle. less Cancers (Basel), 2018 Mar 03; 10(3). PMID: 29495603 Free PMC article. Review.
Combination nivolumab with transcatheter arterial chemoembolization for clinical remission of small cell lung cancer: A case report. Ziwei Guo, Chao Meng, +2 authors, Xing Wei, Chuanhao Tang, Jun Liang. less Thorac Cancer, 2018 Mar 03; 9(5). PMID: 29498219 Free PMC article.
The Rationale and Emerging Use of Neoadjuvant Immune Checkpoint Blockade for Solid Malignancies. Emily Z Keung, Esosa U Ukponmwan, Alexandria P Cogdill, Jennifer A Wargo. Ann Surg Oncol, 2018 Mar 04; 25(7). PMID: 29500764 Free PMC article.
Epigenetic Therapeutics and Their Impact in Immunotherapy of Lung Cancer. Ju Hwan Cho, Filiz Oezkan, +3 authors, Kai He. less Curr Pharmacol Rep, 2018 Mar 06; 3(6). PMID: 29503796 Free PMC article.
Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management. Mark A Samaan, Polychronis Pavlidis, +2 authors, Sophie Papa, Nick Powell, Peter M Irving. less Nat Rev Gastroenterol Hepatol, 2018 Mar 08; 15(4). PMID: 29512649 Review.
The role of programmed death ligand-1 and tumor-infiltrating lymphocytes in breast cancer overexpressing HER2 gene. Yanchun Li, Mateusz Opyrchal, +4 authors, Thaer Khoury. less Breast Cancer Res Treat, 2018 Mar 11; 170(2). PMID: 29524062 Free PMC article.
Physical basis of the 'magnification rule' for standardized Immunohistochemical scoring of HER2 in breast and gastric cancer. Andreas H Scheel, Frédérique Penault-Llorca, +6 authors, Josef Rüschoff. less Diagn Pathol, 2018 Mar 14; 13(1). PMID: 29530054 Free PMC article.
Comprehensive immunohistochemical analysis of PD-L1 shows scarce expression in castration-resistant prostate cancer. Christian D Fankhauser, Peter J Schüffler, +8 authors, Peter J Wild. less Oncotarget, 2018 Mar 15; 9(12). PMID: 29535806 Free PMC article.
New therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles. Takahiro Nakagomi, Taichiro Goto, +8 authors, Masao Omata. less Oncotarget, 2018 Mar 15; 9(12). PMID: 29535832 Free PMC article.
Update on Immunohistochemistry for the Diagnosis of Lung Cancer. Kentaro Inamura. Cancers (Basel), 2018 Mar 15; 10(3). PMID: 29538329 Free PMC article. Review.
Updates on immunotherapy for colorectal cancer. Aparna Kalyan, Sheetal Kircher, +2 authors, Hiral Shah, Mary Mulcahy, Al Benson. less J Gastrointest Oncol, 2018 Mar 23; 9(1). PMID: 29564182 Free PMC article. Highly Cited. Review.
Immunotherapy in colorectal cancer: for the select few or all? Sukeshi Patel Arora, Devalingam Mahalingam. J Gastrointest Oncol, 2018 Mar 23; 9(1). PMID: 29564183 Free PMC article. Review.
Developing rational combinations of immune checkpoint inhibitors and radiation therapy for gastrointestinal cancers. Muhammad Shaalan Beg, Jeffrey Meyer. J Gastrointest Oncol, 2018 Mar 23; 9(1). PMID: 29564188 Free PMC article.
Immunotherapy for Merkel cell carcinoma: a turning point in patient care. Isaac S Chan, Shailender Bhatia, Howard L Kaufman, Evan J Lipson. J Immunother Cancer, 2018 Mar 24; 6(1). PMID: 29566749 Free PMC article. Review.
Correlation of MET gene amplification and TP53 mutation with PD-L1 expression in non-small cell lung cancer. Maher Albitar, Sucha Sudarsanam, +5 authors, Sally Agersborg. less Oncotarget, 2018 Mar 24; 9(17). PMID: 29568386 Free PMC article.
Integrative proteomic and transcriptomic analysis provides evidence for TrkB (NTRK2) as a therapeutic target in combination with tyrosine kinase inhibitors for non-small cell lung cancer. Daniel Richard Gomez, Lauren Averett Byers, +15 authors, John Victor Heymach. less Oncotarget, 2018 Mar 28; 9(18). PMID: 29581842 Free PMC article.
CUP Syndrome-Metastatic Malignancy with Unknown Primary Tumor. Gregor Zaun, Martin Schuler, Ken Herrmann, Andrea Tannapfel. Dtsch Arztebl Int, 2018 Mar 29; 115(10). PMID: 29587959 Free PMC article. Review.
Immunotherapy in surgically resectable non-small cell lung cancer. Dwight Owen, Jamie E Chaft. J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593886 Free PMC article. Review.
Immunotherapy in previously treated non-small cell lung cancer (NSCLC). Ticiana A Leal, Suresh S Ramalingam. J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593888 Free PMC article. Review.
Immunotherapy combination strategies (non-chemotherapy) in non-small cell lung cancer. Sandrine Niyongere, Andreas Saltos, Jhanelle E Gray. J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593889 Free PMC article. Review.
Immune checkpoint inhibitors in small cell lung cancer. Suchita Pakkala, Taofeek K Owonikoko. J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593891 Free PMC article. Review.
Combining radiotherapy and ipilimumab induces clinically relevant radiation-induced abscopal effects in metastatic melanoma patients: A systematic review. Rodolfo Chicas-Sett, Ignacio Morales-Orue, Delvys Rodriguez-Abreu, Pedro Lara-Jimenez. Clin Transl Radiat Oncol, 2018 Mar 30; 9. PMID: 29594244 Free PMC article. Review.
PD-L1 expression and presence of TILs in small intestinal neuroendocrine tumours. Angela Lamarca, Daisuke Nonaka, +10 authors, Juan W Valle. less Oncotarget, 2018 Mar 31; 9(19). PMID: 29599916 Free PMC article.
A pooled analysis of advanced nonsquamous non-small cell lung cancer patients with stable treated brain metastases in two phase II trials receiving bevacizumab and pemetrexed as second-line therapy. Matthew A Gubens, Jody C Chuang, +7 authors, Heather A Wakelee. less J Thorac Dis, 2018 Mar 31; 10(1). PMID: 29600052 Free PMC article.
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. Bin Liu, Yoshiki Arakawa, +10 authors, Susumu Miyamoto. less PLoS One, 2018 Apr 05; 13(4). PMID: 29617441 Free PMC article.
Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma. Hyun-Sung Lee, Hee-Jin Jang, +11 authors, Bryan M Burt. less JCI Insight, 2018 Apr 06; 3(7). PMID: 29618661 Free PMC article.
Sexual Dimorphism of Immune Responses: A New Perspective in Cancer Immunotherapy. Imerio Capone, Paolo Marchetti, +2 authors, Lucia Gabriele. less Front Immunol, 2018 Apr 06; 9. PMID: 29619026 Free PMC article.
Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models. Denise L Crossland, Warren L Denning, +9 authors, John V Heymach. less Oncogene, 2018 Apr 07; 37(27). PMID: 29622795
Clinical assessment of immune-related adverse events. Aaron Sosa, Esther Lopez Cadena, +2 authors, Rafael Rosell. less Ther Adv Med Oncol, 2018 Apr 07; 10. PMID: 29623110 Free PMC article. Review.
Safety and activity of PD-1 blockade-activated DC-CIK cells in patients with advanced solid tumors. Chang-Long Chen, Qiu-Zhong Pan, +17 authors, Jian-Chuan Xia. less Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632736 Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies. Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok. Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946 Free PMC article. Highly Cited. Review.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations. Judith A Seidel, Atsushi Otsuka, Kenji Kabashima. Front Oncol, 2018 Apr 13; 8. PMID: 29644214 Free PMC article. Highly Cited. Review.
Role of PD-1 during effector CD8 T cell differentiation. Eunseon Ahn, Koichi Araki, +7 authors, Rafi Ahmed. less Proc Natl Acad Sci U S A, 2018 Apr 15; 115(18). PMID: 29654146 Free PMC article. Highly Cited.
Neoadjuvant PD-1 Blockade in Resectable Lung Cancer. Patrick M Forde, Jamie E Chaft, +32 authors, Drew M Pardoll. less N Engl J Med, 2018 Apr 17; 378(21). PMID: 29658848 Free PMC article. Highly Cited.
Combination of immunotherapy with chemotherapy and radiotherapy in lung cancer: is this the beginning of the end for cancer? Chiara Lazzari, Niki Karachaliou, +7 authors, Vanesa Gregorc. less Ther Adv Med Oncol, 2018 Apr 18; 10. PMID: 29662546 Free PMC article. Highly Cited. Review.
PD-L1 expression testing in non-small cell lung cancer. Cristina Teixidó, Noelia Vilariño, Roxana Reyes, Noemí Reguart. Ther Adv Med Oncol, 2018 Apr 18; 10. PMID: 29662547 Free PMC article. Highly Cited. Review.
Radiotherapy and checkpoint inhibitors: a winning new combination? Eric C Ko, Silvia C Formenti. Ther Adv Med Oncol, 2018 Apr 18; 10. PMID: 29662550 Free PMC article. Review.
Combination Cancer Immunotherapy in Hepatocellular Carcinoma. Masatoshi Kudo. Liver Cancer, 2018 Apr 18; 7(1). PMID: 29662830 Free PMC article.
Quo Vadis-Do Immunotherapies Have a Role in Glioblastoma? Sylvia C Kurz, Patrick Y Wen. Curr Treat Options Neurol, 2018 Apr 19; 20(5). PMID: 29666934 Review.
Expression of immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death-ligand 1 (PD-L1), in female breast carcinomas. Ari Kassardjian, Peter I Shintaku, Neda A Moatamed. PLoS One, 2018 Apr 20; 13(4). PMID: 29672601 Free PMC article.
A Network Meta-analysis Comparing the Efficacy and Safety of Anti-PD-1 with Anti-PD-L1 in Non-small Cell Lung Cancer. Wei You, Mei Liu, +5 authors, Hao Peng. less J Cancer, 2018 Apr 21; 9(7). PMID: 29675101 Free PMC article.
Elimination of established tumors with nanodisc-based combination chemoimmunotherapy. Rui Kuai, Wenmin Yuan, +5 authors, James J Moon. less Sci Adv, 2018 Apr 21; 4(4). PMID: 29675465 Free PMC article. Highly Cited.
Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma. Dai Kamamoto, Kentaro Ohara, +3 authors, Hikaru Sasaki. less J Neurooncol, 2018 Apr 21; 139(2). PMID: 29675794
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions. Tong Zhang, Xiaomin Song, +20 authors, Kang Li. less Cancer Immunol Immunother, 2018 Apr 25; 67(7). PMID: 29687231 Free PMC article.
Integrative Pharmacology: Advancing Development of Effective Immunotherapies. Mohammad Tabrizi, Daping Zhang, Vaishnavi Ganti, Glareh Azadi. AAPS J, 2018 Apr 29; 20(4). PMID: 29704129 Review.
Immunotherapy after chemoradiotherapy in stage III non-small cell lung cancer: a new standard of care? Anna W Chalmers, Shiven B Patel, Wallace Akerley. J Thorac Dis, 2018 May 01; 10(3). PMID: 29707266 Free PMC article.
Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich. Francesco Iorio, Luz Garcia-Alonso, +4 authors, Julio Saez-Rodriguez. less Sci Rep, 2018 May 02; 8(1). PMID: 29713020 Free PMC article.
PD-L1 testing using the clone 22C3 pharmDx kit for selection of patients with non-small cell lung cancer to receive immune checkpoint inhibitor therapy: are cytology cell blocks a viable option? Vanda F Torous, Deepa Rangachari, +3 authors, Paul A VanderLaan. less J Am Soc Cytopathol, 2018 May 02; 7(3). PMID: 29713584 Free PMC article.
Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II. Howard Y Li, Maria McSharry, +10 authors, Raphael A Nemenoff. less Oncoimmunology, 2018 May 04; 7(5). PMID: 29721380 Free PMC article.
Immunotherapies: Exploiting the Immune System for Cancer Treatment. Jeffrey Koury, Mariana Lucero, +8 authors, Andrew Tran. less J Immunol Res, 2018 May 05; 2018. PMID: 29725606 Free PMC article. Review.
Prognostic impact of programmed cell death ligand 1 (PD-L1) expression and its association with epithelial-mesenchymal transition in extrahepatic cholangiocarcinoma. Takashi Ueno, Takahiro Tsuchikawa, +8 authors, Satoshi Hirano. less Oncotarget, 2018 May 08; 9(28). PMID: 29732001 Free PMC article.
Temozolomide for immunomodulation in the treatment of glioblastoma. Aida Karachi, Farhad Dastmalchi, Duane A Mitchell, Maryam Rahman. Neuro Oncol, 2018 May 08; 20(12). PMID: 29733389 Free PMC article. Review.
Programmed cell death-1 and programmed cell death ligand-1 antibodies-induced dysthyroidism. Jaafar Jaafar, Eugenio Fernandez, Heba Alwan, Jacques Philippe. Endocr Connect, 2018 May 10; 7(5). PMID: 29739808 Free PMC article. Review.
Combination Immunotherapy in Non-small Cell Lung Cancer. Melina E Marmarelis, Charu Aggarwal. Curr Oncol Rep, 2018 May 10; 20(7). PMID: 29740718 Review.
Immunotherapy for pulmonary squamous cell carcinoma and colon carcinoma with pembrolizumab: A case report. Yoshihiro Nozawa, Yuka Oka, Jun Oosugi, Shinichi Takemura. Medicine (Baltimore), 2018 May 10; 97(19). PMID: 29742733 Free PMC article.
Microsatellite Instability Occurs Rarely in Patients with Cholangiocarcinoma: A Retrospective Study from a German Tertiary Care Hospital. Ria Winkelmann, Markus Schneider, +5 authors, Dirk Walter. less Int J Mol Sci, 2018 May 12; 19(5). PMID: 29747443 Free PMC article.
Predicting outcomes in patients with advanced non-small cell lung cancer enrolled in early phase immunotherapy trials. Hossein Maymani, Kenneth Hess, +14 authors, Vivek Subbiah. less Lung Cancer, 2018 May 12; 120. PMID: 29748008 Free PMC article.
Management of gastrointestinal adverse events induced by immune-checkpoint inhibitors. Zheng-Hang Wang, Lin Shen. Chronic Dis Transl Med, 2018 May 15; 4(1). PMID: 29756118 Free PMC article. Review.
Feasibility of re-biopsy and EGFR mutation analysis in patients with non-small cell lung cancer. Tae-Ok Kim, In-Jae Oh, +10 authors, Yoo-Duk Choi. less Thorac Cancer, 2018 May 16; 9(7). PMID: 29761660 Free PMC article.
Clinical characteristics of non-small cell lung cancer harboring mutations in exon 20 of EGFR or HER2. Masayuki Takeda, Kazuko Sakai, +6 authors, Kazuhiko Nakagawa. less Oncotarget, 2018 May 17; 9(30). PMID: 29765525 Free PMC article.
Current landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC). Young Kwang Chae, Ayush Arya, +4 authors, Francis Giles. less J Immunother Cancer, 2018 May 18; 6(1). PMID: 29769148 Free PMC article. Highly Cited. Review.
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma. Ferdinandos Skoulidis, Michael E Goldberg, +66 authors, John V Heymach. less Cancer Discov, 2018 May 19; 8(7). PMID: 29773717 Free PMC article. Highly Cited.
Companion and complementary diagnostics for first-line immune checkpoint inhibitor treatment in non-small cell lung cancer. Jan Trøst Jørgensen, Karsten Bork Nielsen. Transl Lung Cancer Res, 2018 May 22; 7(Suppl 2). PMID: 29780701 Free PMC article.
Constrained Combinatorial Libraries of Gp2 Proteins Enhance Discovery of PD-L1 Binders. Max A Kruziki, Vidur Sarma, Benjamin J Hackel. ACS Comb Sci, 2018 May 26; 20(7). PMID: 29799714 Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer. Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang. less J Mol Biol, 2018 May 26; 430(14). PMID: 29800567 Free PMC article. Review.
Speed of Adoption of Immune Checkpoint Inhibitors of Programmed Cell Death 1 Protein and Comparison of Patient Ages in Clinical Practice vs Pivotal Clinical Trials. Jeremy M O'Connor, Kristen L Fessele, +10 authors, Cary P Gross. less JAMA Oncol, 2018 May 26; 4(8). PMID: 29800974 Free PMC article.
Tumor PD-L1 Expression and Clinical Outcomes in Advanced-stage Non-Small Cell Lung Cancer Patients Treated with Nivolumab or Pembrolizumab: Real-World Data in Taiwan. Shu-Yung Lin, Ching-Yao Yang, +13 authors, Chong-Jen Yu. less J Cancer, 2018 May 29; 9(10). PMID: 29805708 Free PMC article.
Immunohistochemical expression and prognostic value of PD-L1 in Extrapulmonary small cell carcinoma: a single institution experience. Mohammed Salhab, Yazan Migdady, +5 authors, James Liebmann. less J Immunother Cancer, 2018 May 31; 6(1). PMID: 29843803 Free PMC article.
Durvalumab showed long and durable effects after chemoradiotherapy in stage III non-small cell lung cancer: results of the PACIFIC study. Takehiro Uemura, Toyoaki Hida. J Thorac Dis, 2018 Jun 01; 10(Suppl 9). PMID: 29850190 Free PMC article.
CNS cancer immunity cycle and strategies to target this for glioblastoma. Malaka Ameratunga, Niamh Coleman, +2 authors, Liam Welsh, Frank Saran, Juanita Lopez. less Oncotarget, 2018 Jun 02; 9(32). PMID: 29854316 Free PMC article. Review.
Clinicopathological analysis and prognostic significance of programmed cell death-ligand 1 protein and mRNA expression in non-small cell lung cancer. Hyojin Kim, Hyun Jung Kwon, +3 authors, Jin-Haeng Chung. less PLoS One, 2018 Jun 02; 13(6). PMID: 29856861 Free PMC article.
Implementation of immunotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). Anna Tsiara, Michalis Liontos, +3 authors, Meletios-Athanasios Dimopoulos. less Ann Transl Med, 2018 Jun 05; 6(8). PMID: 29862233 Free PMC article. Review.
Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination. Jun Gong, Thang Q Le, +2 authors, Richard Tuli. less J Immunother Cancer, 2018 Jun 06; 6(1). PMID: 29866197 Free PMC article. Review.
Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy. Frederick S Varn, Laura J Tafe, Christopher I Amos, Chao Cheng. Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872556 Free PMC article.
Addressing the challenges of applying precision oncology. Seung Ho Shin, Ann M Bode, Zigang Dong. NPJ Precis Oncol, 2018 Jun 07; 1(1). PMID: 29872710 Free PMC article. Review.
A Phase II Study of Pembrolizumab in EGFR-Mutant, PD-L1+, Tyrosine Kinase Inhibitor Naïve Patients With Advanced NSCLC. A Lisberg, A Cummings, +23 authors, Edward B Garon. less J Thorac Oncol, 2018 Jun 07; 13(8). PMID: 29874546 Free PMC article. Highly Cited.
Proton beam therapy and immunotherapy: an emerging partnership for immune activation in non-small cell lung cancer. Howard J Lee, Jing Zeng, Ramesh Rengan. Transl Lung Cancer Res, 2018 Jun 08; 7(2). PMID: 29876317 Free PMC article. Review.
Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring. Yumi Katsume, Tsuyoshi Isawa, +4 authors, Tatsushi Ootomo. less Intern Med, 2018 Jun 08; 57(21). PMID: 29877257 Free PMC article.
The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature. Akifumi Tabei, Mitsuharu Watanabe, +8 authors, Keiju Hiromura. less Intern Med, 2018 Jun 08; 57(21). PMID: 29877267 Free PMC article. Review.
Intracranial Response to Nivolumab in a Patient with PD-L1-negative Lung Adenocarcinoma. Yoshiro Nakahara, Tomoya Fukui, +12 authors, Katsuhiko Naoki. less Intern Med, 2018 Jun 08; 57(21). PMID: 29877291 Free PMC article.
Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies. Philipp Metzger, Sabrina V Kirchleitner, +5 authors, Peter Duewell. less Sci Rep, 2018 Jun 13; 8(1). PMID: 29892077 Free PMC article.
Immune checkpoint inhibitors in urothelial cancer: recent updates and future outlook. Dharmesh Gopalakrishnan, Vadim S Koshkin, +2 authors, Petros Grivas. less Ther Clin Risk Manag, 2018 Jun 13; 14. PMID: 29892196 Free PMC article. Review.
Tumor molecular profiling of responders and non-responders following pembrolizumab monotherapy in chemotherapy resistant advanced cervical cancer. N Y L Ngoi, V Heong, +9 authors, D S P Tan. less Gynecol Oncol Rep, 2018 Jun 13; 24. PMID: 29892689 Free PMC article.
The concentration of programmed cell death-ligand 1 in the peripheral blood is a useful biomarker for esophageal squamous cell carcinoma. Yasunori Akutsu, Kentaro Murakami, +8 authors, Hisahiro Matsubara. less Esophagus, 2018 Jun 13; 15(2). PMID: 29892935
Development of a radionuclide-labeled monoclonal anti-CD55 antibody with theranostic potential in pleural metastatic lung cancer. So Hee Dho, Soo Yong Kim, +8 authors, Jae Cheong Lim. less Sci Rep, 2018 Jun 14; 8(1). PMID: 29895866 Free PMC article.
PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study. Giulia Bertolini, Luca Bergamaschi, +11 authors, Patrizia Gasparini. less BMC Cancer, 2018 Jun 15; 18(1). PMID: 29898687 Free PMC article.
Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma. Felipe Gálvez-Cancino, Ernesto López, +11 authors, Alvaro Lladser. less Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900048 Free PMC article.
Increase in PD-L1 expression after pre-operative radiotherapy for soft tissue sarcoma. Kirtesh R Patel, Anthony Martinez, +12 authors, Karen D Godette. less Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900051 Free PMC article.
Isolation and molecular analysis of circulating tumor cells from lung cancer patients using a microfluidic chip type cell sorter. Masaru Watanabe, Hirotsugu Kenmotsu, +11 authors, Toshiaki Takahashi. less Cancer Sci, 2018 Jun 15; 109(8). PMID: 29900633 Free PMC article.
Rapidly changing treatment algorithms for metastatic nonsquamous non-small-cell lung cancer. B Melosky. Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910649 Free PMC article. Review.
Current landscape of immunotherapy for the treatment of metastatic non-small-cell lung cancer. A Pabani, C A Butts. Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910652 Free PMC article. Review.
Advances in the systemic treatment of triple-negative breast cancer. J M Lebert, R Lester, +2 authors, E Powell, M Seal, J McCarthy. less Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910657 Free PMC article. Highly Cited. Review.
Predictors of Response to Autologous Dendritic Cell Therapy in Glioblastoma Multiforme. Chia-Ing Jan, Wan-Chen Tsai, +5 authors, Der-Yang Cho. less Front Immunol, 2018 Jun 19; 9. PMID: 29910795 Free PMC article.
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment. Aubhishek Zaman, Trever G Bivona. Ann Transl Med, 2018 Jun 19; 6(9). PMID: 29911108 Free PMC article. Review.
Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma. Chao-Qun Liu, Jing Xu, +7 authors, Limin Zheng. less Br J Cancer, 2018 Jun 21; 119(1). PMID: 29921949 Free PMC article.
Risk of hematologic toxicities with programmed cell death-1 inhibitors in cancer patients: a meta-analysis of current studies. Jiang-Dong Sui, Ying Wang, Yue Wan, Yong-Zhong Wu. Drug Des Devel Ther, 2018 Jun 21; 12. PMID: 29922039 Free PMC article.
Construction of an anti-programmed death-ligand 1 chimeric antigen receptor and determination of its antitumor function with transduced cells. Jiasen Xie, Zishan Zhou, Shunchang Jiao, Xiaokun Li. Oncol Lett, 2018 Jun 22; 16(1). PMID: 29928397 Free PMC article.
Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA). Patrick Danaher, Sarah Warren, +6 authors, Alessandra Cesano. less J Immunother Cancer, 2018 Jun 23; 6(1). PMID: 29929551 Free PMC article. Highly Cited.
Association of Immune-Related Adverse Events with Clinical Benefit in Patients with Advanced Non-Small-Cell Lung Cancer Treated with Nivolumab. Yukihiro Toi, Shunichi Sugawara, +14 authors, Yoshihiro Honda. less Oncologist, 2018 Jun 24; 23(11). PMID: 29934411 Free PMC article. Highly Cited.
PD-L1 Expression On tumor Cells Was Associated With Unfavorable Prognosis In Esophageal Squamous Cell Carcinoma. Qiao Wang, Fan Feng, +7 authors, Hongwei Zhang. less J Cancer, 2018 Jun 26; 9(12). PMID: 29937943 Free PMC article.
PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy. Verena Rolfes, Christian Idel, +8 authors, Barbara Wollenberg. less Oncotarget, 2018 Jun 26; 9(44). PMID: 29937998 Free PMC article.
30 Immunotherapy in advanced NSCLC-from the 'tsunami' of therapeutic knowledge to a clinical practice algorithm: results from an international expert panel meeting of the Italian Association of Thoracic Oncology (AIOT). Filippo de Marinis, Fortunato Ciardiello, +10 authors, Cesare Gridelli. less ESMO Open, 2018 Jun 27; 3(4). PMID: 29942662 Free PMC article. Review.
Changes in programmed death ligand 1 expression in non-small cell lung cancer patients who received anticancer treatments. Shota Omori, Hirotsugu Kenmotsu, +14 authors, Toshiaki Takahashi. less Int J Clin Oncol, 2018 Jun 28; 23(6). PMID: 29948239
Locally-advanced non-small cell lung cancer: shall immunotherapy be a new chance? Andrea Riccardo Filippi, Jacopo Di Muzio, +2 authors, Serena Badellino, Cristina Mantovani, Umberto Ricardi. less J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951297 Free PMC article. Review.
Immunotherapy in the Asiatic population: any differences from Caucasian population? Lunxi Peng, Yi-Long Wu. J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951300 Free PMC article. Review.
Do immune checkpoint inhibitors need new studies methodology? Roberto Ferrara, Sara Pilotto, +7 authors, Emilio Bria. less J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951307 Free PMC article. Review.
Key questions about the checkpoint blockade-are microRNAs an answer? Mihnea Dragomir, Baoqing Chen, Xiao Fu, George A Calin. Cancer Biol Med, 2018 Jun 29; 15(2). PMID: 29951335 Free PMC article.
Efficacy and safety of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma: pooled analyses after long-term follow-up in KEYNOTE-012. Ranee Mehra, Tanguy Y Seiwert, +17 authors, Robert Haddad. less Br J Cancer, 2018 Jun 30; 119(2). PMID: 29955135 Free PMC article. Highly Cited.
Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future. Mark A Perazella, Anushree C Shirali. J Am Soc Nephrol, 2018 Jul 01; 29(8). PMID: 29959196 Free PMC article. Highly Cited. Review.
Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers. Muhammad Umair Mushtaq, Athanasios Papadas, +4 authors, Fotis Asimakopoulos. less J Immunother Cancer, 2018 Jul 05; 6(1). PMID: 29970158 Free PMC article. Review.
A Longitudinal Investigation of Internalized Stigma, Constrained Disclosure, and Quality of Life Across 12 Weeks in Lung Cancer Patients on Active Oncologic Treatment. Timothy J Williamson, Alyssa K Choi, +7 authors, Annette L Stanton. less J Thorac Oncol, 2018 Jul 10; 13(9). PMID: 29981926 Free PMC article.
A clinical analysis of 114 cases of sarcomatoid carcinoma of the lung. Junna Hou, Lihua Xing, Yufen Yuan. Clin Exp Med, 2018 Jul 11; 18(4). PMID: 29987681
Systemically Administered Sindbis Virus in Combination with Immune Checkpoint Blockade Induces Curative Anti-tumor Immunity. Iris Scherwitzl, Alicia Hurtado, +3 authors, Daniel Meruelo. less Mol Ther Oncolytics, 2018 Jul 11; 9. PMID: 29988525 Free PMC article.
Biomarkers for Clinical Benefit of Immune Checkpoint Inhibitor Treatment-A Review From the Melanoma Perspective and Beyond. Kristina Buder-Bakhaya, Jessica C Hassel. Front Immunol, 2018 Jul 14; 9. PMID: 30002656 Free PMC article. Highly Cited. Review.
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC). Julie R Brahmer, Ramaswamy Govindan, +18 authors, Roy S Herbst. less J Immunother Cancer, 2018 Jul 18; 6(1). PMID: 30012210 Free PMC article.
The Potential of In Vivo Imaging for Optimization of Molecular and Cellular Anti-cancer Immunotherapies. Gilbert O Fruhwirth, Manfred Kneilling, +3 authors, Erik H J G Aarntzen. less Mol Imaging Biol, 2018 Jul 22; 20(5). PMID: 30030697 Free PMC article. Review.
New PDL1 inhibitors for non-small cell lung cancer: focus on pembrolizumab. Olivier Bylicki, Nicolas Paleiron, Gaëlle Rousseau-Bussac, Christos Chouaïd. Onco Targets Ther, 2018 Jul 25; 11. PMID: 30038505 Free PMC article. Review.
Real world data of nivolumab for previously treated non-small cell lung cancer patients: a Galician lung cancer group clinical experience. Mª Carmen Areses Manrique, Joaquín Mosquera Martínez, +17 authors, José Luis Fírvida Pérez. less Transl Lung Cancer Res, 2018 Jul 28; 7(3). PMID: 30050778 Free PMC article.
Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic. S P Kang, K Gergich, +4 authors, E H Rubin. less Ann Oncol, 2018 Jul 28; 28(6). PMID: 30052728 Free PMC article.
Emerging strategies for combination checkpoint modulators in cancer immunotherapy. Aleksandra Popovic, Elizabeth M Jaffee, Neeha Zaidi. J Clin Invest, 2018 Aug 02; 128(8). PMID: 30067248 Free PMC article. Highly Cited. Review.
A tertiary care cancer center experience with carboplatin and pemetrexed in combination with pembrolizumab in comparison with carboplatin and pemetrexed alone in non-squamous non-small cell lung cancer. Muhammad Zubair Afzal, Konstantin Dragnev, Keisuke Shirai. J Thorac Dis, 2018 Aug 03; 10(6). PMID: 30069355 Free PMC article.
Randomized phase II study of fulvestrant and erlotinib compared with erlotinib alone in patients with advanced or metastatic non-small cell lung cancer. Edward B Garon, Jill M Siegfried, +21 authors, Richard J Pietras. less Lung Cancer, 2018 Aug 10; 123. PMID: 30089602 Free PMC article.
Requirement for MUC5AC in KRAS-dependent lung carcinogenesis. Alison K Bauer, Misha Umer, +19 authors, Seyed Javad Moghaddam. less JCI Insight, 2018 Aug 10; 3(15). PMID: 30089720 Free PMC article.
Low-dose nivolumab can be effective in non-small cell lung cancer: alternative option for financial toxicity. Shin Hye Yoo, Bhumsuk Keam, +6 authors, Dae Seog Heo. less ESMO Open, 2018 Aug 11; 3(5). PMID: 30094065 Free PMC article.
Phase II study assessing the benefit of cisplatin re-introduction (stop-and-go strategy) in patients with advanced non-squamous non-small cell lung cancer: the IFCT-1102 BUCiL study (a Better Use of Cisplatin in Lung cancer). Jaafar Bennouna, Fabrice Barlesi, +10 authors, Pierre-Jean Souquet. less ESMO Open, 2018 Aug 11; 3(5). PMID: 30094074 Free PMC article.
Immune Checkpoint Inhibitor-related Pneumonitis. Incidence, Risk Factors, and Clinical and Radiographic Features. Rebecca Sternschein, Matthew Moll, Julie Ng, Carolyn D'Ambrosio. Am J Respir Crit Care Med, 2018 Aug 11; 198(7). PMID: 30095979 Free PMC article.
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers. S N Gettinger, J Choi, +19 authors, K A Schalper. less Nat Commun, 2018 Aug 12; 9(1). PMID: 30097571 Free PMC article.
Dendritic cell vaccines for high-grade gliomas. Matthew E Eagles, Farshad Nassiri, +4 authors, Kenneth D Aldape. less Ther Clin Risk Manag, 2018 Aug 14; 14. PMID: 30100728 Free PMC article. Review.
Combining Immune Checkpoint Inhibitors With Conventional Cancer Therapy. Yiyi Yan, Anagha Bangalore Kumar, +4 authors, Haidong Dong. less Front Immunol, 2018 Aug 14; 9. PMID: 30100909 Free PMC article. Highly Cited. Review.
PD-L1 expression comparison between primary and relapsed non-small cell lung carcinoma using whole sections and clone SP263. Enrico Munari, Giuseppe Zamboni, +13 authors, Giuseppe Bogina. less Oncotarget, 2018 Aug 14; 9(54). PMID: 30101000 Free PMC article.
Treatment of Complications from Immune Checkpoint Inhibition in Patients with Lung Cancer. Beatriz Wills, Julie R Brahmer, Jarushka Naidoo. Curr Treat Options Oncol, 2018 Aug 14; 19(9). PMID: 30101402 Free PMC article. Review.
Targeting the Microenvironment in High Grade Serous Ovarian Cancer. Nkechiyere G Nwani, Livia E Sima, Wilberto Nieves-Neira, Daniela Matei. Cancers (Basel), 2018 Aug 15; 10(8). PMID: 30103384 Free PMC article. Review.
Personalized medicine in non-small cell lung cancer: a review from a pharmacogenomics perspective. Wenxiao Jiang, Guiqing Cai, Peter C Hu, Yue Wang. Acta Pharm Sin B, 2018 Aug 16; 8(4). PMID: 30109178 Free PMC article. Review.
Targeting the PD-1/PD-L1 axis for the treatment of non-small-cell lung cancer. D E Meyers, P M Bryan, S Banerji, D G Morris. Curr Oncol, 2018 Aug 17; 25(4). PMID: 30111979 Free PMC article. Review.
Comparative analysis of immune checkpoint inhibitors and chemotherapy in the treatment of advanced non-small cell lung cancer: A meta-analysis of randomized controlled trials. Muhammad Khan, Jie Lin, +5 authors, Yawei Yuan. less Medicine (Baltimore), 2018 Aug 17; 97(33). PMID: 30113497 Free PMC article. Review.
Abscopal effect of radiotherapy combined with immune checkpoint inhibitors. Yang Liu, Yinping Dong, +3 authors, Li Kong, Fang Shi, Hui Zhu, Jinming Yu. less J Hematol Oncol, 2018 Aug 18; 11(1). PMID: 30115069 Free PMC article. Highly Cited. Review.
Effective nivolumab sequential thoracic radiotherapy in elderly patients with advanced squamous cell lung cancer: did radiation therapy play a role? A case report. Grazia Lazzari, Angela Terlizzi, +4 authors, Giovanni Silvano. less Onco Targets Ther, 2018 Aug 21; 11. PMID: 30122953 Free PMC article.
Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease. Julius L Decano, Masanori Aikawa. Front Cardiovasc Med, 2018 Aug 21; 5. PMID: 30123798 Free PMC article. Review.
PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin - case report. Jonathan W Goldman, Basmah Abdalla, +4 authors, Erik L Lum. less BMC Nephrol, 2018 Aug 22; 19(1). PMID: 30126374 Free PMC article.
Design considerations for early-phase clinical trials of immune-oncology agents. Nolan A Wages, Cody Chiuzan, Katherine S Panageas. J Immunother Cancer, 2018 Aug 24; 6(1). PMID: 30134959 Free PMC article.
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance. Young-Jun Park, Da-Sol Kuen, Yeonseok Chung. Exp Mol Med, 2018 Aug 24; 50(8). PMID: 30135516 Free PMC article. Highly Cited. Review.
Epigenetic mechanisms of tumor resistance to immunotherapy. Natalia Arenas-Ramirez, Dilara Sahin, Onur Boyman. Cell Mol Life Sci, 2018 Aug 25; 75(22). PMID: 30140960 Review.
MEK inhibitors for the treatment of NRAS mutant melanoma. Saro Sarkisian, Diwakar Davar. Drug Des Devel Ther, 2018 Aug 30; 12. PMID: 30154648 Free PMC article. Review.
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options. Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül. Front Immunol, 2018 Aug 31; 9. PMID: 30158932 Free PMC article. Review.
Anti-PD-1/PD-L1 Therapy for Non-Small-Cell Lung Cancer: Toward Personalized Medicine and Combination Strategies. Hongshu Sui, Ningxia Ma, +4 authors, Jiali Yang. less J Immunol Res, 2018 Aug 31; 2018. PMID: 30159341 Free PMC article. Highly Cited. Review.
Strategies for Predicting Response to Checkpoint Inhibitors. Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub. Curr Hematol Malig Rep, 2018 Aug 31; 13(5). PMID: 30159703 Free PMC article. Review.
Fatal enteric plexus neuropathy after one dose of ipilimumab plus nivolumab: a case report. Jacob Appelbaum, David Wells, +7 authors, Shailender Bhatia. less J Immunother Cancer, 2018 Sep 02; 6(1). PMID: 30170630 Free PMC article.
[Research Progress of Immunotherapy for Brain Metastases in Patients  with Drive Gene Negative NSCLC]. Shuang Zhang, Jingjing Liu, +2 authors, Changliang Yang, Shuang Li, Ying Cheng. less Zhongguo Fei Ai Za Zhi, 2018 Sep 03; 21(8). PMID: 30172268 Free PMC article. Review.
Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study. Melin J Khandekar, Rakesh Jain. Transl Cancer Res, 2018 Sep 04; 7(Suppl 1). PMID: 30175050 Free PMC article.
Treatment of mycophenolate-resistant immune-related organizing pneumonia with infliximab. Guacimara Ortega Sanchez, Kathleen Jahn, +2 authors, Spasenija Savic, Alfred Zippelius, Heinz Läubli. less J Immunother Cancer, 2018 Sep 05; 6(1). PMID: 30176946 Free PMC article.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints. Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min. less Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160 Free PMC article. Review.
PD-L1 in melanoma: facts and myths. Mario Mandalà, Barbara Merelli, Daniela Massi. Melanoma Manag, 2016 Sep 01; 3(3). PMID: 30190888 Free PMC article. Review.
Immuno-Oncology: Emerging Targets and Combination Therapies. Henry T Marshall, Mustafa B A Djamgoz. Front Oncol, 2018 Sep 08; 8. PMID: 30191140 Free PMC article. Highly Cited. Review.
Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy. Shouheng Lin, Guohua Huang, +23 authors, Peng Li. less MAbs, 2018 Sep 12; 10(8). PMID: 30204048 Free PMC article.
Checkpoint-inhibition in ovarian cancer: rising star or just a dream? Klaus Pietzner, Sara Nasser, +4 authors, Jalid Sehouli. less J Gynecol Oncol, 2018 Sep 13; 29(6). PMID: 30207101 Free PMC article. Review.
A phase I/randomized phase II study of GM.CD40L vaccine in combination with CCL21 in patients with advanced lung adenocarcinoma. Jhanelle E Gray, Alberto Chiappori, +15 authors, Scott J Antonia. less Cancer Immunol Immunother, 2018 Sep 14; 67(12). PMID: 30209589 Free PMC article.
Long-term survival of locally advanced stage III non-small cell lung cancer patients treated with chemoradiotherapy and perspectives for the treatment with immunotherapy. Martina Vrankar, Karmen Stanic. Radiol Oncol, 2018 Sep 14; 52(3). PMID: 30210037 Free PMC article.
New advances in immunotherapy for non-small cell lung cancer. Haifeng Qin, Fang Wang, +4 authors, Hongjun Gao. less Am J Transl Res, 2018 Sep 14; 10(8). PMID: 30210667 Free PMC article. Review.
New strategies in immunotherapy for lung cancer: beyond PD-1/PD-L1. Nicolas Villanueva, Lyudmila Bazhenova. Ther Adv Respir Dis, 2018 Sep 15; 12. PMID: 30215300 Free PMC article. Review.
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia. Marina Wierz, Bassam Janji, +2 authors, Guy Berchem, Etienne Moussay, Jerome Paggetti. less Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221064 Free PMC article.
A novel bispecific antibody for EGFR-directed blockade of the PD-1/PD-L1 immune checkpoint. Iris Koopmans, Djoke Hendriks, +5 authors, Wijnand Helfrich. less Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221065 Free PMC article.
Autochthonous murine models for the study of smoker and never-smoker associated lung cancers. Esra A Akbay, James Kim. Transl Lung Cancer Res, 2018 Sep 19; 7(4). PMID: 30225211 Free PMC article. Review.
Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab. Shiro Kimbara, Yutaka Fujiwara, +7 authors, Yuichiro Ohe. less Cancer Sci, 2018 Sep 20; 109(11). PMID: 30230649 Free PMC article.
Novel Quantitative Imaging for Predicting Response to Therapy: Techniques and Clinical Applications. Kaustav Bera, Vamsidhar Velcheti, Anant Madabhushi. Am Soc Clin Oncol Educ Book, 2018 Sep 21; 38. PMID: 30231314 Free PMC article. Review.
The role of automated cytometry in the new era of cancer immunotherapy. Marco Danova, Martina Torchio, +3 authors, Giuliano Mazzini. less Mol Clin Oncol, 2018 Sep 21; 9(4). PMID: 30233791 Free PMC article. Review.
Immunotherapy for Merkel Cell Carcinoma. Kotaro Nagase, Yutaka Narisawa. Curr Treat Options Oncol, 2018 Sep 22; 19(11). PMID: 30238195 Review.
Pleural or pericardial metastasis: A significant factor affecting efficacy and adverse events in lung cancer patients treated with PD-1/PD-L1 inhibitors. Da Hyun Kang, Chaeuk Chung, +6 authors, Jeong Eun Lee. less Thorac Cancer, 2018 Sep 27; 9(11). PMID: 30253080 Free PMC article.
Response to PD1 inhibition in conventional chondrosarcoma. Michael J Wagner, Robert W Ricciotti, +3 authors, Lee D Cranmer. less J Immunother Cancer, 2018 Sep 27; 6(1). PMID: 30253794 Free PMC article.
Genomic Characterization of Six Virus-Associated Cancers Identifies Changes in the Tumor Immune Microenvironment and Altered Genetic Programs. Frederick S Varn, Evelien Schaafsma, Yue Wang, Chao Cheng. Cancer Res, 2018 Sep 27; 78(22). PMID: 30254145 Free PMC article.
Establishment of a prospective multicenter cohort for advanced non-small cell lung cancer in China (CAPTRA-Lung study). Yan Xu, Li Zhang, +17 authors, Mengzhao Wang. less Thorac Cancer, 2018 Sep 29; 9(12). PMID: 30264504 Free PMC article.
Efficacy of anti-PD-1/PD-L1 antibodies after discontinuation due to adverse events in non-small cell lung cancer patients (HANSHIN 0316). Motoko Tachihara, Shunichi Negoro, +8 authors, Soichiro Yokota. less BMC Cancer, 2018 Oct 05; 18(1). PMID: 30285770 Free PMC article.
The systemic immune-inflammation index is an independent predictor of survival for metastatic colorectal cancer and its association with the lymphocytic response to the tumor. Qian-Kun Xie, Ping Chen, +10 authors, Liang-Ping Xia. less J Transl Med, 2018 Oct 06; 16(1). PMID: 30286769 Free PMC article.
Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy. Jinfang Zhang, Fabin Dang, Junming Ren, Wenyi Wei. Trends Biochem Sci, 2018 Oct 06; 43(12). PMID: 30287140 Free PMC article. Review.
Combination with SGT-53 overcomes tumor resistance to a checkpoint inhibitor. Sang-Soo Kim, Joe B Harford, +2 authors, Manish Moghe, Antonina Rait, Esther H Chang. less Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288347 Free PMC article.
Tobacco smoking and cessation and PD-L1 inhibitors in non-small cell lung cancer (NSCLC): a review of the literature. Jan Norum, Carsten Nieder. ESMO Open, 2018 Oct 12; 3(6). PMID: 30305940 Free PMC article.
Safety of combined PD-1 pathway inhibition and radiation therapy for non-small-cell lung cancer: A multicentric retrospective study from the GFPC. Paul Lesueur, Alexandre Escande, +9 authors, Radj Gervais. less Cancer Med, 2018 Oct 13; 7(11). PMID: 30311424 Free PMC article.
Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients. Marius Ilié, Mélanie Ngo-Mai, +6 authors, Paul Hofman. less J Vis Exp, 2018 Oct 16; (139). PMID: 30320751 Free PMC article.
Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer. Ewelina Grywalska, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński. Onco Targets Ther, 2018 Oct 17; 11. PMID: 30323625 Free PMC article. Review.
Pembrolizumab for the treatment of patients with recurrent locally advanced or metastatic gastric or gastroesophageal junction cancer: an evidence-based review of place in therapy. Rutika Mehta, Anand Shah, Khaldoun Almhanna. Onco Targets Ther, 2018 Oct 17; 11. PMID: 30323626 Free PMC article. Review.
Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer. Bin Shao, Chia-Wei Li, +11 authors, Mien-Chie Hung. less Am J Cancer Res, 2018 Oct 17; 8(9). PMID: 30323975 Free PMC article.
The 8th edition AJCC/UICC TNM staging for p16-positive oropharyngeal carcinoma: is there space for improvement? Shachi Jenny Sharma, Steffen Wagner, +4 authors, Claus Wittekindt. less Eur Arch Otorhinolaryngol, 2018 Oct 18; 275(12). PMID: 30327906
Hyperprogressive disease in patients with non-small cell lung cancer treated with nivolumab: A case series. Masaki Kanazu, Ryuya Edahiro, +7 authors, Masahide Mori. less Thorac Cancer, 2018 Oct 18; 9(12). PMID: 30328672 Free PMC article.
Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into Checkpoint-Responsive Tumors by Reprogramming Tumor-Infiltrating MDSCs. Brian J Christmas, Christine I Rafie, +9 authors, Evanthia T Roussos Torres. less Cancer Immunol Res, 2018 Oct 21; 6(12). PMID: 30341213 Free PMC article.
Somatic mutation profiling of liver and biliary cancer by targeted next generation sequencing. Bo-Lun Zhang, Xu Ji, +18 authors, Hu Tian. less Oncol Lett, 2018 Oct 23; 16(5). PMID: 30344748 Free PMC article.
Predictive biomarkers for tumor immune checkpoint blockade. Mengting Tong, Jing Wang, +4 authors, Hongliang Zhang. less Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349382 Free PMC article. Review.
Characteristics and outcomes of patients with recurrent ovarian cancer undergoing early phase immune checkpoint inhibitor clinical trials. Emily Hinchcliff, David Hong, +5 authors, Amir Jazaeri. less Gynecol Oncol, 2018 Oct 28; 151(3). PMID: 30366646 Free PMC article.
[Predictive value of PD-L1 diagnostics]. H-U Schildhaus. Pathologe, 2018 Oct 28; 39(6). PMID: 30367225 Review.
Generating antitumor immunity by targeted radiation therapy: Role of dose and fractionation. Eric C Ko, Kimberly Thomas Benjamin, Silvia C Formenti. Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370347 Free PMC article. Review.
βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors. Michal Chovanec, Zuzana Cierna, +10 authors, Jozef Mardiak. less BMC Cancer, 2018 Nov 06; 18(1). PMID: 30390643 Free PMC article.
Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities. Mathew Suji Eapen, Philip M Hansbro, +16 authors, Sukhwinder Singh Sohal. less Drugs, 2018 Nov 06; 78(16). PMID: 30392114 Review.
Strategies for first-line immunotherapy in squamous cell lung cancer: are combinations a game changer? Niki Karachaliou, Manuel Fernandez-Bruno, Rafael Rosell. Transl Lung Cancer Res, 2018 Nov 06; 7(Suppl 3). PMID: 30393600 Free PMC article.
Cytology versus histology for programmed death-ligand 1 expression evaluation in the landscape of non-small cell lung cancer patients selection for immunotherapy. Umberto Malapelle, Antonino Iacca

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