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Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Maria Romina Girotti, Filipa Lopes, +25 authors, Natasha Preece, Dan Niculescu-Duvaz, Alfonso Zambon, Lawrence Davies, Steven Whittaker, Grazia Saturno, Amaya Viros, Malin Pedersen, Bart M J M Suijkerbuijk, Delphine Menard, Robert McLeary, Louise Johnson, Laura Fish, Sarah Ejiama, Berta Sanchez-Laorden, Juliane Hohloch, Neil Carragher, Kenneth Macleod, Garry Ashton, Anna A Marusiak, Alberto Fusi, John Brognard, Margaret Frame, Paul Lorigan, Richard Marais, Caroline Springer. less Cancer Cell, 2014 Dec 17; 27(1). PMID: 25500121 Free PMC article. Highly Cited.
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Molecular insights into pediatric brain tumors have the potential to transform therapy. Amar Gajjar, Stefan M Pfister, Michael D Taylor, Richard J Gilbertson. Clin Cancer Res, 2014 Nov 16; 20(22). PMID: 25398846 Free PMC article. Review.
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CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance. Sami Ventelä, Eleonora Sittig, +8 authors, Leni Mannermaa, Juho-Antti Mäkelä, Jarmo Kulmala, Eliisa Löyttyniemi, Leena Strauss, Olli Cárpen, Jorma Toppari, Reidar Grénman, Jukka Westermarck. less Oncotarget, 2014 Dec 05; 6(1). PMID: 25474139 Free PMC article.
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No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients. Maria Romina Girotti, Grazia Saturno, Paul Lorigan, Richard Marais. Mol Oncol, 2014 Sep 03; 8(6). PMID: 25178978 Free PMC article. Review.
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Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition. Patricia A Possik, Judith Müller, +14 authors, Carmen Gerlach, Juliana C N Kenski, Xinyao Huang, Aida Shahrabi, Oscar Krijgsman, Ji-Ying Song, Marjon A Smit, Bram Gerritsen, Cor Lieftink, Kristel Kemper, Magali Michaut, Roderick L Beijersbergen, Lodewyk Wessels, Ton N Schumacher, Daniel S Peeper. less Cell Rep, 2014 Dec 03; 9(4). PMID: 25456132
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Stromal cell-induced miRNA alteration in chronic lymphocytic leukemia: how a minute and unavoidable cell contamination impairs miRNA profiling. J Paggetti, G Berchem, E Moussay. Leukemia, 2013 Feb 15; 27(8). PMID: 23407459
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Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma. Maria R Girotti, Malin Pedersen, +12 authors, Berta Sanchez-Laorden, Amaya Viros, Samra Turajlic, Dan Niculescu-Duvaz, Alfonso Zambon, John Sinclair, Andrew Hayes, Martin Gore, Paul Lorigan, Caroline Springer, James Larkin, Claus Jorgensen, Richard Marais. less Cancer Discov, 2012 Dec 18; 3(2). PMID: 23242808 Free PMC article. Highly Cited.
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MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia. Etienne Moussay, Kai Wang, +8 authors, Ji-Hoon Cho, Kris van Moer, Sandrine Pierson, Jérôme Paggetti, Petr V Nazarov, Valérie Palissot, Leroy E Hood, Guy Berchem, David J Galas. less Proc Natl Acad Sci U S A, 2011 Apr 05; 108(16). PMID: 21460253 Free PMC article.
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BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling. Berta Sanchez-Laorden, Amaya Viros, +12 authors, Maria Romina Girotti, Malin Pedersen, Grazia Saturno, Alfonso Zambon, Dan Niculescu-Duvaz, Samra Turajlic, Andrew Hayes, Martin Gore, James Larkin, Paul Lorigan, Martin Cook, Caroline Springer, Richard Marais. less Sci Signal, 2014 Mar 29; 7(318). PMID: 24667377
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