Journal Article
. 2015 May; 27(5):290-6.
doi: 10.1179/1973947815Y.0000000015.

Is adjuvant chemotherapy omissible in women with T1-2 stage, node-positive, luminal A type breast cancer?

Hee Yong Kwak  Byung Joo Chae  Yong Hwa Eom  Young Ran Hong  Jae Beom Seo  Ja Seong Bae  Sang Seol Jung  Byung Joo Song  
  • PMID: 25974160
  •     5 citations

Abstract

Purpose: The aim of this study was to evaluate whether hormonal breast cancer therapy without systemic chemotherapy is feasible in adjuvant settings in luminal A breast cancer.

Methods: A database of 879 patients who underwent breast cancer surgery enrolled between January 2003 and December 2011 was reviewed. Patients with luminal A cancers were selected and grouped into those who received adjuvant hormonal therapy with (group C+) or without (group C - ) adjuvant systemic therapy.

Results: In a multivariable analysis, axillary lymph node (ALN) metastasis was the only independent factor that revealed significantly different between the two groups in disease-free survival (DFS). The 5-year cumulative DFS was 82.3 versus 76.2% (P = 0.700) and overall survival (OS) was 83.9 versus 100% (P = 0.483) for C+ versus C -  breast cancer, respectively.

Conclusion: In our study, adjuvant chemotherapy in luminal A, T1-2N+ cancer showed no significant difference for DFS. We believe that the role of adjuvant chemotherapy for these women with hormonal therapy might have little benefit.

Keywords: Breast,; Carcinoma,; Chemotherapy,; Survival.

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