Journal Article
. 2015 Jul; 33(25):2772-9.
doi: 10.1200/JCO.2015.60.8133.

Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial

Otto Metzger Filho 1 Anita Giobbie-Hurder 2 Elizabeth Mallon 2 Barry Gusterson 2 Giuseppe Viale 2 Eric P Winer 2 Beat Thürlimann 2 Richard D Gelber 2 Marco Colleoni 2 Bent Ejlertsen 2 Marc Debled 2 Karen N Price 2 Meredith M Regan 2 Alan S Coates 2 Aron Goldhirsch 2 
Affiliations
  • PMID: 26215945
  •     43 References
  •     44 citations

Abstract

Purpose: To evaluate the relative effectiveness of letrozole compared with tamoxifen for patients with invasive ductal or lobular carcinoma.

Patients And Methods: Patients diagnosed with early-stage invasive ductal carcinoma (IDC) or classic invasive lobular carcinoma (ILC) who were randomly assigned onto the Breast International Group (BIG) 1-98 trial and who had centrally reviewed pathology data were included (N = 2,923). HER2-negative IDC and ILC were additionally classified as hormone receptor-positive with high (luminal B [LB] -like) or low (luminal A [LA] -like) proliferative activity by Ki-67 labeling index. Survival analyses were performed with weighted Cox models that used inverse probability of censoring weighted modeling.

Results: The median follow-up time was 8.1 years. In multivariable models for disease-free survival (DFS), significant interactions between treatment and histology (ILC or IDC; P = .006) and treatment and subgroup (LB like or LA like; P = .01) were observed. In the ILC subset, there was a 66% reduction in the hazard of a DFS event with letrozole for LB (hazard ratio [HR], 0.34; 95% CI, 0.21 to 0.55) and a 50% reduction for LA subtypes (HR, 0.50; 95% CI, 0.32 to 0.78). In the IDC subset, there was a significant 35% reduction in the hazard of a DFS event with letrozole for the LB subtype (HR, 0.65; 95% CI, 0.53 to 0.79), but no difference between treatments was noted for IDC and the LA subtype (HR, 0.95; 95% CI, 0.76 to 1.20).

Conclusion: The magnitude of benefit of adjuvant letrozole is greater for patients diagnosed with lobular carcinoma versus ductal carcinoma.

Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011.
A Goldhirsch, W C Wood, +4 authors, Panel members.
Ann Oncol, 2011 Jun 29; 22(8). PMID: 21709140    Free PMC article.
Highly Cited.
Invasive lobular carcinoma of the breast: response to hormonal therapy and outcomes.
Emad A Rakha, Maysa E El-Sayed, +9 authors, Ian O Ellis.
Eur J Cancer, 2007 Nov 24; 44(1). PMID: 18035533
Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up.
Meredith M Regan, Patrick Neven, +14 authors, International Breast Cancer Study Group (IBCSG).
Lancet Oncol, 2011 Oct 25; 12(12). PMID: 22018631    Free PMC article.
Highly Cited.
Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer.
Meredith M Regan, Karen N Price, +3 authors, International Breast Cancer Study Group and BIG 1-98 Collaborative Group.
Breast Cancer Res, 2011 Jun 04; 13(3). PMID: 21635709    Free PMC article.
Review.
Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group.
Mitch Dowsett, Torsten O Nielsen, +19 authors, International Ki-67 in Breast Cancer Working Group.
J Natl Cancer Inst, 2011 Oct 01; 103(22). PMID: 21960707    Free PMC article.
Highly Cited.
Invasive lobular breast cancer: subtypes and outcome.
Monica Iorfida, Eugenio Maiorano, +11 authors, Giuseppe Viale.
Breast Cancer Res Treat, 2012 Mar 09; 133(2). PMID: 22399188
Aromatase inhibition in obese women: how much is enough?
Jennifer A Ligibel, Eric P Winer.
J Clin Oncol, 2012 Jul 18; 30(24). PMID: 22802318
Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer.
Esther H Lips, Rita A Mukhtar, +13 authors, I-SPY TRIAL Investigators.
Breast Cancer Res Treat, 2012 Sep 11; 136(1). PMID: 22961065    Free PMC article.
Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the breast international group 1-98 trial.
Marianne Ewertz, Kathryn P Gray, +14 authors, Henning T Mouridsen.
J Clin Oncol, 2012 Oct 10; 30(32). PMID: 23045588    Free PMC article.
Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer.
Aleix Prat, Maggie Chon U Cheang, +8 authors, Charles M Perou.
J Clin Oncol, 2012 Dec 13; 31(2). PMID: 23233704    Free PMC article.
Highly Cited.
Influence of semi-quantitative oestrogen receptor expression on adjuvant endocrine therapy efficacy in ductal and lobular breast cancer - a TEAM study analysis.
Willemien van de Water, Duveken B Y Fontein, +12 authors, Cornelis J H van de Velde.
Eur J Cancer, 2012 Sep 08; 49(2). PMID: 22954666
Genomic grade adds prognostic value in invasive lobular carcinoma.
O Metzger-Filho, S Michiels, +19 authors, C Sotiriou.
Ann Oncol, 2012 Oct 03; 24(2). PMID: 23028037
Clinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas.
Y Delpech, C Coutant, +7 authors, L Pusztai.
Br J Cancer, 2013 Jan 10; 108(2). PMID: 23299541    Free PMC article.
Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013.
A Goldhirsch, E P Winer, +5 authors, Panel members.
Ann Oncol, 2013 Aug 07; 24(9). PMID: 23917950    Free PMC article.
Highly Cited.
Patterns of Recurrence and outcome according to breast cancer subtypes in lymph node-negative disease: results from international breast cancer study group trials VIII and IX.
Otto Metzger-Filho, Zhuoxin Sun, +8 authors, Fatima Cardoso.
J Clin Oncol, 2013 Jul 31; 31(25). PMID: 23897954    Free PMC article.
Highly Cited.
Differential expression of estrogen receptor α, β1, and β2 in lobular and ductal breast cancer.
Bo Huang, Yoko Omoto, +6 authors, Jan-Åke Gustafsson.
Proc Natl Acad Sci U S A, 2014 Jan 23; 111(5). PMID: 24449868    Free PMC article.
Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response.
Matthew J Sikora, Kristine L Cooper, +7 authors, Steffi Oesterreich.
Cancer Res, 2014 Jan 16; 74(5). PMID: 24425047    Free PMC article.
Molecular portraits of human breast tumours.
C M Perou, T Sørlie, +15 authors, D Botstein.
Nature, 2000 Aug 30; 406(6797). PMID: 10963602
Highly Cited.
A prospective trial of preoperative chemotherapy in resectable breast cancer: predictors of breast-conservation therapy feasibility.
Lisa A Newman, Aman U Buzdar, +5 authors, Kelly K Hunt.
Ann Surg Oncol, 2002 Mar 30; 9(3). PMID: 11923128
Trends in incidence rates of invasive lobular and ductal breast carcinoma.
Christopher I Li, Benjamin O Anderson, Janet R Daling, Roger E Moe.
JAMA, 2003 Mar 15; 289(11). PMID: 12636465
Different responses to preoperative chemotherapy for invasive lobular and invasive ductal breast carcinoma.
V F Cocquyt, P N Blondeel, +7 authors, S J P Van Belle.
Eur J Surg Oncol, 2003 Apr 25; 29(4). PMID: 12711290
The poor responsiveness of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be explained by their biological profile.
M-C Mathieu, R Rouzier, +6 authors, M Spielmann.
Eur J Cancer, 2004 Jan 30; 40(3). PMID: 14746851
Invasive lobular carcinoma classic type: response to primary chemotherapy and survival outcomes.
Massimo Cristofanilli, Ana Gonzalez-Angulo, +9 authors, Gabriel N Hortobagyi.
J Clin Oncol, 2004 Dec 31; 23(1). PMID: 15625359
American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004.
Eric P Winer, Clifford Hudis, +19 authors, Mark R Somerfield.
J Clin Oncol, 2004 Nov 17; 23(3). PMID: 15545664
Highly Cited. Review.
Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial.
Raimund Jakesz, Walter Jonat, +12 authors, ABCSG and the GABG.
Lancet, 2005 Aug 09; 366(9484). PMID: 16084253
Highly Cited.
Pathology parameters and adjuvant tamoxifen response in a randomised premenopausal breast cancer trial.
K Jirström, L Rydén, +7 authors, G Landberg.
J Clin Pathol, 2005 Oct 29; 58(11). PMID: 16254100    Free PMC article.
A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer.
Breast International Group (BIG) 1-98 Collaborative Group, Beat Thürlimann, +13 authors, Aron Goldhirsch.
N Engl J Med, 2005 Dec 31; 353(26). PMID: 16382061
Highly Cited.
Response to neoadjuvant chemotherapy in lobular and ductal breast carcinomas: a retrospective study on 860 patients from one institution.
M Tubiana-Hulin, D Stevens, +5 authors, J Rouëssé.
Ann Oncol, 2006 Jun 03; 17(8). PMID: 16740599
Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial.
Birgitte B Rasmussen, Meredith M Regan, +17 authors, BIG 1-98 Collaborative and International Breast Cancer Study Groups.
Lancet Oncol, 2007 Dec 18; 9(1). PMID: 18083065
Predictive value of tumor Ki-67 expression in two randomized trials of adjuvant chemoendocrine therapy for node-negative breast cancer.
Giuseppe Viale, Meredith M Regan, +16 authors, International Breast Cancer Study Group.
J Natl Cancer Inst, 2008 Jan 31; 100(3). PMID: 18230798
High rates of breast conservation for large ductal and lobular invasive carcinomas combining multimodality strategies.
M A Bollet, A Savignoni, +9 authors, A Vincent-Salomon.
Br J Cancer, 2008 Feb 07; 98(4). PMID: 18253121    Free PMC article.
ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer.
Rebecca B Riggins, Jennifer P-J Lan, +9 authors, Robert Clarke.
Cancer Res, 2008 Nov 01; 68(21). PMID: 18974135    Free PMC article.
Prognostic and predictive value of centrally reviewed Ki-67 labeling index in postmenopausal women with endocrine-responsive breast cancer: results from Breast International Group Trial 1-98 comparing adjuvant tamoxifen with letrozole.
Giuseppe Viale, Anita Giobbie-Hurder, +18 authors, Breast International Group Trial 1-98.
J Clin Oncol, 2008 Nov 05; 26(34). PMID: 18981464    Free PMC article.
Highly Cited.
Gene-expression signatures in breast cancer.
Christos Sotiriou, Lajos Pusztai.
N Engl J Med, 2009 Feb 21; 360(8). PMID: 19228622
Highly Cited. Review.
Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.
Maggie C U Cheang, Stephen K Chia, +10 authors, Torsten O Nielsen.
J Natl Cancer Inst, 2009 May 14; 101(10). PMID: 19436038    Free PMC article.
Highly Cited.
Design, conduct, and analyses of Breast International Group (BIG) 1-98: a randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer.
Anita Giobbie-Hurder, Karen N Price, +2 authors, BIG 1-98 Collaborative Group.
Clin Trials, 2009 Jun 17; 6(3). PMID: 19528136    Free PMC article.
Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009.
A Goldhirsch, J N Ingle, +4 authors, Panel members.
Ann Oncol, 2009 Jun 19; 20(8). PMID: 19535820    Free PMC article.
Highly Cited.
Lobular breast carcinoma and its variants.
Emad A Rakha, Ian O Ellis.
Semin Diagn Pathol, 2010 Mar 24; 27(1). PMID: 20306830
Review.
American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
M Elizabeth H Hammond, Daniel F Hayes, +29 authors, Antonio C Wolff.
J Clin Oncol, 2010 Apr 21; 28(16). PMID: 20404251    Free PMC article.
Highly Cited. Systematic Review.
Correcting for discretionary treatment crossover in an analysis of survival in the Breast International Group BIG 1-98 trial by using the inverse probability of censoring weighted method.
Dianne M Finkelstein, David A Schoenfeld.
J Clin Oncol, 2011 Feb 16; 29(9). PMID: 21321297
Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial.
G Viale, M M Regan, +17 authors, BIG 1-98 Collaborative and International Breast Cancer Study Groups.
Ann Oncol, 2011 Feb 22; 22(10). PMID: 21335417    Free PMC article.
Invasive ductal carcinoma and invasive lobular carcinoma of breast differ in response following neoadjuvant therapy with epidoxorubicin and docetaxel + G-CSF.
Catharina Wenzel, Rupert Bartsch, +8 authors, Guenther G Steger.
Breast Cancer Res Treat, 2006 Oct 25; 104(1). PMID: 17061042
Analyses adjusting for selective crossover show improved overall survival with adjuvant letrozole compared with tamoxifen in the BIG 1-98 study.
Marco Colleoni, Anita Giobbie-Hurder, +14 authors, Aron Goldhirsch.
J Clin Oncol, 2011 Feb 16; 29(9). PMID: 21321298    Free PMC article.
Differences between invasive lobular and invasive ductal carcinoma of the breast: results and therapeutic implications.
Romualdo Barroso-Sousa, Otto Metzger-Filho.
Ther Adv Med Oncol, 2016 Aug 03; 8(4). PMID: 27482285    Free PMC article.
Review.
WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines.
Matthew J Sikora, Britta M Jacobsen, +5 authors, Steffi Oesterreich.
Breast Cancer Res, 2016 Sep 22; 18(1). PMID: 27650553    Free PMC article.
De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017.
G Curigliano, H J Burstein, +52 authors, B Xu.
Ann Oncol, 2017 Aug 26; 28(8). PMID: 28838210    Free PMC article.
Highly Cited.
Invasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinoma.
Zheling Chen, Jiao Yang, +9 authors, Jin Yang.
PLoS One, 2017 Sep 02; 12(9). PMID: 28863134    Free PMC article.
Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities.
Hillary Stires, Mary M Heckler, +10 authors, Rebecca B Riggins.
Mol Cell Endocrinol, 2017 Sep 25; 471. PMID: 28935545    Free PMC article.
Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism.
Tian Du, Li Zhu, +6 authors, Steffi Oesterreich.
Sci Rep, 2018 May 10; 8(1). PMID: 29739984    Free PMC article.
Association of Somatic Driver Alterations With Prognosis in Postmenopausal, Hormone Receptor-Positive, HER2-Negative Early Breast Cancer: A Secondary Analysis of the BIG 1-98 Randomized Clinical Trial.
Stephen J Luen, Rebecca Asher, +13 authors, Sherene Loi.
JAMA Oncol, 2018 Jun 15; 4(10). PMID: 29902286    Free PMC article.
Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors.
Alison M Nagle, Kevin M Levine, +9 authors, Adrian V Lee.
Clin Cancer Res, 2018 Jun 27; 24(20). PMID: 29941485    Free PMC article.
Breast Cancers of Special Histologic Subtypes Are Biologically Diverse.
Audree B Tadros, Hannah Y Wen, Monica Morrow.
Ann Surg Oncol, 2018 Aug 11; 25(11). PMID: 30094484    Free PMC article.
Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.
Tian Du, Matthew J Sikora, +5 authors, Steffi Oesterreich.
Breast Cancer Res, 2018 Sep 06; 20(1). PMID: 30180878    Free PMC article.
Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
Yeji An, Jessica R Adams, +19 authors, Sean E Egan.
Cell Rep, 2018 Oct 18; 25(3). PMID: 30332649    Free PMC article.
Lobular breast carcinoma metastatic to the endometrium in a patient under tamoxifen therapy: A case report.
Mariangela Gomez, Kerry Whitting, Rana Naous.
SAGE Open Med Case Rep, 2020 Feb 29; 8. PMID: 32110411    Free PMC article.
Adjuvant chemotherapy could not bring survival benefit to HR-positive, HER2-negative, pT1b-c/N0-1/M0 invasive lobular carcinoma of the breast: a propensity score matching study based on SEER database.
Guangfu Hu, Guangxia Hu, +8 authors, Cheng Xu.
BMC Cancer, 2020 Feb 23; 20(1). PMID: 32085753    Free PMC article.
Prognostic Impact of Menopausal Hormone Therapy in Breast Cancer Differs According to Tumor Characteristics and Treatment.
Christopher Godina, Erik Ottander, +3 authors, Helena Jernström.
Front Oncol, 2020 Mar 03; 10. PMID: 32117735    Free PMC article.
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.
Ilirjana Bajrami, Rebecca Marlow, +28 authors, Christopher J Lord.
Cancer Discov, 2018 Apr 04; 8(4). PMID: 29610289    Free PMC article.
Comprehensive Phenotypic Characterization of Human Invasive Lobular Carcinoma Cell Lines in 2D and 3D Cultures.
Nilgun Tasdemir, Emily A Bossart, +7 authors, Steffi Oesterreich.
Cancer Res, 2018 Sep 20; 78(21). PMID: 30228172    Free PMC article.
Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer.
E S Sokol, Y X Feng, +12 authors, R J Hartmaier.
Ann Oncol, 2018 Nov 14; 30(1). PMID: 30423024    Free PMC article.
FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype.
Kevin M Levine, Nolan Priedigkeit, +17 authors, Steffi Oesterreich.
NPJ Breast Cancer, 2019 Jul 03; 5. PMID: 31263748    Free PMC article.
Mixed Invasive Ductal and Lobular Carcinoma of the Breast: Prognosis and the Importance of Histologic Grade.
Otto Metzger-Filho, Arlindo R Ferreira, +7 authors, Nancy U Lin.
Oncologist, 2018 Dec 07; 24(7). PMID: 30518616    Free PMC article.
Efficacy of Single-Agent Chemotherapy for Patients with Advanced Invasive Lobular Carcinoma: A Pooled Analysis from Three Clinical Trials.
José Pérez-Garcia, Javier Cortés, Otto Metzger Filho.
Oncologist, 2018 Dec 24; 24(8). PMID: 30578311    Free PMC article.
Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study.
Jamie R Kutasovic, Amy E McCart Reed, +16 authors, Peter T Simpson.
J Pathol Clin Res, 2018 Sep 25; 5(1). PMID: 30246500    Free PMC article.
Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.
Ugo Testa, Germana Castelli, Elvira Pelosi.
Med Sci (Basel), 2020 Mar 27; 8(1). PMID: 32210163    Free PMC article.
Review.
Overcoming Endocrine Resistance in Breast Cancer.
Ariella B Hanker, Dhivya R Sudhan, Carlos L Arteaga.
Cancer Cell, 2020 Apr 15; 37(4). PMID: 32289273    Free PMC article.
Review.
SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinoma.
Emily A Bossart, Nilgun Tasdemir, +7 authors, Steffi Oesterreich.
Breast Cancer Res Treat, 2019 Feb 25; 175(2). PMID: 30798422    Free PMC article.
Patient treatment and outcome after breast cancer orbital and periorbital metastases: a comprehensive case series including analysis of lobular versus ductal tumor histology.
Martin Blohmer, Li Zhu, +9 authors, Rachel C Jankowitz.
Breast Cancer Res, 2020 Jun 27; 22(1). PMID: 32586354    Free PMC article.
Proteomic and transcriptomic profiling identifies mediators of anchorage-independent growth and roles of inhibitor of differentiation proteins in invasive lobular carcinoma.
Nilgun Tasdemir, Kai Ding, +7 authors, Steffi Oesterreich.
Sci Rep, 2020 Jul 15; 10(1). PMID: 32661241    Free PMC article.
Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.
Jocelyn Luveta, Ruth M Parks, +2 authors, Simon J Johnston.
Oncol Ther, 2020 Jul 24; 8(1). PMID: 32700069    Free PMC article.
Review.
Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.
Sasagu Kurozumi, Mansour Alsaleem, +12 authors, Simon J Johnston.
Breast Cancer Res, 2020 Aug 13; 22(1). PMID: 32782013    Free PMC article.
Differential Regulation and Targeting of Estrogen Receptor α Turnover in Invasive Lobular Breast Carcinoma.
Sreeja Sreekumar, Kevin M Levine, +12 authors, Steffi Oesterreich.
Endocrinology, 2020 Jul 02; 161(9). PMID: 32609836    Free PMC article.
LobSig is a multigene predictor of outcome in invasive lobular carcinoma.
Amy E McCart Reed, Samir Lal, +18 authors, Peter T Simpson.
NPJ Breast Cancer, 2019 Jul 03; 5. PMID: 31263747    Free PMC article.
Validation of the Prognostic Stage of American Joint Committee on Cancer Eighth Edition Staging Manual in Invasive Lobular Carcinoma Compared to Invasive Ductal Carcinoma and Proposal of a Novel Score System.
Shuning Ding, Yu Zong, +8 authors, Li Zhu.
Front Oncol, 2020 Oct 06; 10. PMID: 33014784    Free PMC article.
Guidance and Standards for Breast Cancer Care in Europe.
Rudy Leon De Wilde, Rajesh Devassy, +3 authors, Cristina Cezar.
J Obstet Gynaecol India, 2020 Oct 13; 70(5). PMID: 33041548    Free PMC article.
Review.
Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4.
Madeleine T Shackleford, Deviyani M Rao, +5 authors, Matthew J Sikora.
Cancers (Basel), 2020 Oct 16; 12(10). PMID: 33053661    Free PMC article.
Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas.
Lindsay A Williams, Katherine A Hoadley, +5 authors, Melissa A Troester.
Cancer Causes Control, 2019 Jan 09; 30(1). PMID: 30617775    Free PMC article.
Lobular Breast Cancer: A Review.
Natalie Wilson, Alastair Ironside, Anna Diana, Olga Oikonomidou.
Front Oncol, 2021 Feb 02; 10. PMID: 33520704    Free PMC article.
Review.
Molecular Subtype May Be More Associated With Prognosis and Chemotherapy Benefit Than Tumor Size in T1N0 Breast Cancer Patients: An Analysis of 2,168 Patients for Possible De-Escalation Treatment.
Siji Zhu, Yafen Li, +3 authors, Xiaosong Chen.
Front Oncol, 2021 Mar 09; 11. PMID: 33680973    Free PMC article.
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1.
George Sflomos, Laura Battista, +10 authors, Cathrin Brisken.
EMBO Mol Med, 2021 Feb 23; 13(3). PMID: 33616307    Free PMC article.
Risk of recurrence among patients with HR-positive, HER2-negative, early breast cancer receiving adjuvant endocrine therapy: A systematic review and meta-analysis.
Elizabeth M Salvo, Abril Oliva Ramirez, +4 authors, Imtiaz A Samjoo.
Breast, 2021 Mar 08; 57. PMID: 33677313    Free PMC article.
Comprehensive Review of Molecular Mechanisms and Clinical Features of Invasive Lobular Cancer.
Nikhil Pramod, Akanksha Nigam, +7 authors, Bhuvaneswari Ramaswamy.
Oncologist, 2021 Mar 01; 26(6). PMID: 33641217    Free PMC article.
Review.
Trends in endocrine therapy prescription and survival in patients with non-metastatic hormone receptor positive breast cancer treated with endocrine therapy: A population based-study.
Ariane Mamguem Kamga, Oumar Billa, +7 authors, Tienhan Sandrine Dabakuyo-Yonli.
Breast, 2021 Jun 27; 59. PMID: 34174766    Free PMC article.
Evidence on Efficacy and Safety of Chinese Medicines Combined Western Medicines Treatment for Breast Cancer With Endocrine Therapy.
Lu Li, Rongyun Wang, +8 authors, Xiaohui Fan.
Front Oncol, 2021 Jul 09; 11. PMID: 34235077    Free PMC article.
Systematic Review.
How Researchers, Clinicians and Patient Advocates Can Accelerate Lobular Breast Cancer Research.
Leigh Pate, Christine Desmedt, +4 authors, Steffi Oesterreich.
Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34206261    Free PMC article.
Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast.
Joseph L Sottnik, Evelyn K Bordeaux, +4 authors, Matthew J Sikora.
Mol Cancer Res, 2021 May 06; 19(8). PMID: 33947745    Free PMC article.
Survival patterns of invasive lobular and invasive ductal breast cancer in a large population-based cohort with two decades of follow up.
C Chamalidou, H Fohlin, +8 authors, Swedish western and south-eastern breast cancer groups.
Breast, 2021 Aug 14; 59. PMID: 34388695    Free PMC article.