Review
. 2015 Aug; 14(8):561-84.
doi: 10.1038/nrd4591.

Combination cancer immunotherapy and new immunomodulatory targets

Kathleen M Mahoney 1 Paul D Rennert 2 Gordon J Freeman 3 
Affiliations
  • PMID: 26228759
  •     233 References
  •     463 citations

Abstract

Targeting immune checkpoints such as programmed cell death protein 1 (PD1), programmed cell death 1 ligand 1 (PDL1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has achieved noteworthy benefit in multiple cancers by blocking immunoinhibitory signals and enabling patients to produce an effective antitumour response. Inhibitors of CTLA4, PD1 or PDL1 administered as single agents have resulted in durable tumour regression in some patients, and combinations of PD1 and CTLA4 inhibitors may enhance antitumour benefit. Numerous additional immunomodulatory pathways as well as inhibitory factors expressed or secreted by myeloid and stromal cells in the tumour microenvironment are potential targets for synergizing with immune checkpoint blockade. Given the breadth of potential targets in the immune system, critical questions to address include which combinations should move forward in development and which patients will benefit from these treatments. This Review discusses the leading drug targets that are expressed on tumour cells and in the tumour microenvironment that allow enhancement of the antitumour immune response.

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Plasma protein beta-2-glycoprotein 1 mediates interaction between the anti-tumor monoclonal antibody 3G4 and anionic phospholipids on endothelial cells.
Troy A Luster, Jin He, +4 authors, Philip E Thorpe.
J Biol Chem, 2006 Aug 15; 281(40). PMID: 16905548
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
Xiaozhou Fan, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2014 Apr 02; 211(4). PMID: 24687957    Free PMC article.
Highly Cited.
CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells.
Zhi-Zhang Yang, Anne J Novak, +2 authors, Stephen M Ansell.
Blood, 2007 Jul 07; 110(7). PMID: 17615291    Free PMC article.
B7-H3 and B7-H4 expression in non-small-cell lung cancer.
Yuping Sun, Yunshan Wang, +4 authors, Xiongbiao Wang.
Lung Cancer, 2006 Jun 20; 53(2). PMID: 16782226
Highly Cited.
B7-H5 costimulates human T cells via CD28H.
Yuwen Zhu, Sheng Yao, +13 authors, Lieping Chen.
Nat Commun, 2013 Jun 21; 4. PMID: 23784006    Free PMC article.
A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors.
Amita Patnaik, Patricia M LoRusso, +13 authors, Colin D Weekes.
Cancer Chemother Pharmacol, 2014 Mar 19; 73(5). PMID: 24633809
Myeloid suppressor cell depletion augments antitumor activity in lung cancer.
Minu K Srivastava, Li Zhu, +9 authors, Sherven Sharma.
PLoS One, 2012 Jul 21; 7(7). PMID: 22815789    Free PMC article.
Highly Cited.
Ipilimumab in patients with melanoma and autoimmune disease.
Chrisann Kyi, Richard D Carvajal, Jedd D Wolchok, Michael A Postow.
J Immunother Cancer, 2014 Oct 29; 2(1). PMID: 25349698    Free PMC article.
Historical review: Cytokines as therapeutics and targets of therapeutics.
Jan Vilcek, Marc Feldmann.
Trends Pharmacol Sci, 2004 Apr 06; 25(4). PMID: 15063084
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma.
Omid Hamid, Caroline Robert, +23 authors, Antoni Ribas.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724846    Free PMC article.
Highly Cited.
Nivolumab in previously untreated melanoma without BRAF mutation.
Caroline Robert, Georgina V Long, +25 authors, Paolo A Ascierto.
N Engl J Med, 2014 Nov 18; 372(4). PMID: 25399552
Highly Cited.
Cancer classification using the Immunoscore: a worldwide task force.
Jérôme Galon, Franck Pagès, +61 authors, Bernard A Fox.
J Transl Med, 2012 Oct 05; 10. PMID: 23034130    Free PMC article.
Highly Cited. Review.
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
Ilona Kryczek, Linhua Zou, +12 authors, Weiping Zou.
J Exp Med, 2006 Apr 12; 203(4). PMID: 16606666    Free PMC article.
Highly Cited.
Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.
Camilla Jandus, Kayluz Frias Boligan, +11 authors, Stephan von Gunten.
J Clin Invest, 2014 Feb 27; 124(4). PMID: 24569453    Free PMC article.
Highly Cited.
Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production.
Julia A Brown, David M Dorfman, +5 authors, Gordon J Freeman.
J Immunol, 2003 Jan 23; 170(3). PMID: 12538684
Highly Cited.
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma.
Caroline Robert, Luc Thomas, +21 authors, Jedd D Wolchok.
N Engl J Med, 2011 Jun 07; 364(26). PMID: 21639810
Highly Cited.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.
Adam J Adler, Anthony T Vella.
Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23482891    Free PMC article.
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Lieping Chen, Dallas B Flies.
Nat Rev Immunol, 2013 Mar 09; 13(4). PMID: 23470321    Free PMC article.
Highly Cited. Review.
Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain.
Min Shi, Margaretha G M Roemer, +6 authors, Scott J Rodig.
Am J Surg Pathol, 2014 Jul 16; 38(12). PMID: 25025450    Free PMC article.
Targeting CD137 enhances the efficacy of cetuximab.
Holbrook E Kohrt, A Dimitrios Colevas, +20 authors, Ronald Levy.
J Clin Invest, 2014 May 20; 124(6). PMID: 24837434    Free PMC article.
Highly Cited.
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Y Latchman, C R Wood, +18 authors, G J Freeman.
Nat Immunol, 2001 Feb 27; 2(3). PMID: 11224527
Highly Cited.
Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer.
Nicolas A Giraldo, Etienne Becht, +17 authors, Catherine Sautès-Fridman.
Clin Cancer Res, 2015 Feb 18; 21(13). PMID: 25688160
Highly Cited.
Hematological malignancies escape from NK cell innate immune surveillance: mechanisms and therapeutic implications.
Laure Farnault, Carole Sanchez, +2 authors, Régis T Costello.
Clin Dev Immunol, 2012 Aug 18; 2012. PMID: 22899948    Free PMC article.
Review.
Towards next generation adenosine A(2A) receptor antagonists.
G Yuan, G B Jones.
Curr Med Chem, 2014 Sep 02; 21(34). PMID: 25174927
Review.
T cells: neuropilin 1 - distinguishing TReg cell subsets.
Maria Papatriantafyllou.
Nat Rev Immunol, 2012 Sep 29; 12(11). PMID: 23018290
Primary hypothyroidism associated with interleukin-2 and interferon alpha-2 therapy of melanoma and renal carcinoma.
S Scalzo, A Gengaro, +7 authors, E E Holdener.
Eur J Cancer, 1990 Jan 01; 26(11-12). PMID: 2149997
BRAF inhibition improves tumor recognition by the immune system: Potential implications for combinatorial therapies against melanoma involving adoptive T-cell transfer.
Marco Donia, Paolo Fagone, +5 authors, Inge Marie Svane.
Oncoimmunology, 2012 Dec 25; 1(9). PMID: 23264894    Free PMC article.
The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA-E through mostly shared but partly distinct sets of HLA-E residues.
Haruka Wada, Naoki Matsumoto, +2 authors, Kazuo Yamamoto.
Eur J Immunol, 2004 Feb 19; 34(1). PMID: 14971033
Pembrolizumab versus Ipilimumab in Advanced Melanoma.
Caroline Robert, Jacob Schachter, +20 authors, KEYNOTE-006 investigators.
N Engl J Med, 2015 Apr 22; 372(26). PMID: 25891173
Highly Cited.
Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas.
Xingxing Zang, Peggy S Sullivan, +10 authors, James P Allison.
Mod Pathol, 2010 May 25; 23(8). PMID: 20495537    Free PMC article.
Correlation between NK function and response to trastuzumab in metastatic breast cancer patients.
Alessandra Beano, Elena Signorino, +7 authors, Lina Matera.
J Transl Med, 2008 May 20; 6. PMID: 18485193    Free PMC article.
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
G J Freeman, A J Long, +16 authors, T Honjo.
J Exp Med, 2000 Oct 04; 192(7). PMID: 11015443    Free PMC article.
Highly Cited.
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.
KiBem Kim, Andrew D Skora, +8 authors, Shibin Zhou.
Proc Natl Acad Sci U S A, 2014 Jul 30; 111(32). PMID: 25071169    Free PMC article.
Highly Cited.
NKG2D ligands as therapeutic targets.
Paul Spear, Ming-Ru Wu, Marie-Louise Sentman, Charles L Sentman.
Cancer Immun, 2013 Jul 09; 13. PMID: 23833565    Free PMC article.
Highly Cited. Review.
First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity.
Chrystelle Brignone, Maya Gutierrez, +9 authors, Frédéric Triebel.
J Transl Med, 2010 Jul 27; 8. PMID: 20653948    Free PMC article.
Neuropilins: a new target for cancer therapy.
Camille Grandclement, Christophe Borg.
Cancers (Basel), 2011 Jan 01; 3(2). PMID: 24212788    Free PMC article.
Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade.
Zachary A Cooper, Vikram R Juneja, +12 authors, Jennifer A Wargo.
Cancer Immunol Res, 2014 Jun 07; 2(7). PMID: 24903021    Free PMC article.
Highly Cited.
PD-1 and its ligands in tolerance and immunity.
Mary E Keir, Manish J Butte, Gordon J Freeman, Arlene H Sharpe.
Annu Rev Immunol, 2008 Jan 05; 26. PMID: 18173375
Highly Cited. Review.
Improved survival with vemurafenib in melanoma with BRAF V600E mutation.
Paul B Chapman, Axel Hauschild, +26 authors, BRIM-3 Study Group.
N Engl J Med, 2011 Jun 07; 364(26). PMID: 21639808    Free PMC article.
Highly Cited.
OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.
Yannick Bulliard, Rose Jolicoeur, +3 authors, Jennifer L Brogdon.
Immunol Cell Biol, 2014 Apr 16; 92(6). PMID: 24732076
Highly Cited.
Alpha 1 antichymotrypsin is aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma.
Yang Wang, Helen Jiang, +10 authors, Youwen Zhou.
Pigment Cell Melanoma Res, 2010 May 07; 23(4). PMID: 20444200
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.
Christine Feig, James O Jones, +12 authors, Douglas T Fearon.
Proc Natl Acad Sci U S A, 2013 Nov 28; 110(50). PMID: 24277834    Free PMC article.
Highly Cited.
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.
Robert J Johnston, Laetitia Comps-Agrar, +9 authors, Jane L Grogan.
Cancer Cell, 2014 Dec 04; 26(6). PMID: 25465800
Highly Cited.
Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Stephen M Hatfield, Jorgen Kjaergaard, +15 authors, Michail V Sitkovsky.
Sci Transl Med, 2015 Mar 06; 7(277). PMID: 25739764    Free PMC article.
Highly Cited.
Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade.
Simon J Dovedi, Amy L Adlard, +11 authors, Tim M Illidge.
Cancer Res, 2014 Oct 03; 74(19). PMID: 25274032
Highly Cited.
Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein.
Murali Janakiram, Jordan M Chinai, +11 authors, Xingxing Zang.
Clin Cancer Res, 2015 Jan 01; 21(10). PMID: 25549724    Free PMC article.
Hepatotoxicity with combination of vemurafenib and ipilimumab.
Antoni Ribas, F Stephen Hodi, +2 authors, Jedd Wolchok.
N Engl J Med, 2013 Apr 05; 368(14). PMID: 23550685
Highly Cited.
T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.
Rosemarie H DeKruyff, Xia Bu, +9 authors, José M Casasnovas.
J Immunol, 2010 Jan 20; 184(4). PMID: 20083673    Free PMC article.
Highly Cited.
Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.
N M Valiante, G Trinchieri.
J Exp Med, 1993 Oct 01; 178(4). PMID: 8376943    Free PMC article.
Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity.
Christine Pasero, Daniel Olive.
Immunol Lett, 2013 Feb 27; 151(1-2). PMID: 23439006
Review.
From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer.
Helen Angell, Jérôme Galon.
Curr Opin Immunol, 2013 Apr 13; 25(2). PMID: 23579076
Highly Cited. Review.
Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells.
Liza B John, Christel Devaud, +7 authors, Phillip K Darcy.
Clin Cancer Res, 2013 Jul 23; 19(20). PMID: 23873688
Highly Cited.
VISTA Regulates the Development of Protective Antitumor Immunity.
Isabelle Le Mercier, Wenna Chen, +5 authors, Li Wang.
Cancer Res, 2014 Apr 03; 74(7). PMID: 24691994    Free PMC article.
Highly Cited.
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.
Chen Zhu, Ana C Anderson, +6 authors, Vijay K Kuchroo.
Nat Immunol, 2005 Nov 16; 6(12). PMID: 16286920
Highly Cited.
Clinical significance of the B7-H4 coregulatory molecule as a novel prognostic marker in gastric cancer.
Takaaki Arigami, Yoshikazu Uenosono, +3 authors, Shoji Natsugoe.
World J Surg, 2011 Jul 13; 35(9). PMID: 21748517
Targeting hypoxia in cancer therapy.
William R Wilson, Michael P Hay.
Nat Rev Cancer, 2011 May 25; 11(6). PMID: 21606941
Highly Cited. Review.
Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies.
Shravan Madireddi, So-Young Eun, +7 authors, Michael Croft.
J Exp Med, 2014 Jun 25; 211(7). PMID: 24958847    Free PMC article.
Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy.
Atul Bedi, Xiaofei Chang, +9 authors, Rajani Ravi.
Mol Cancer Ther, 2012 Aug 29; 11(11). PMID: 22927667    Free PMC article.
B7-H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma.
Lu-jun Chen, Jing Sun, +6 authors, Xue-guang Zhang.
Cancer Immunol Immunother, 2011 Apr 27; 60(7). PMID: 21519829
Neuropilin 1: function and therapeutic potential in cancer.
Belal Chaudhary, Yazan S Khaled, Basil J Ammori, Eyad Elkord.
Cancer Immunol Immunother, 2013 Nov 23; 63(2). PMID: 24263240
Review.
A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission.
Norbert Vey, Jean-Henri Bourhis, +9 authors, Daniel Olive.
Blood, 2012 Sep 25; 120(22). PMID: 23002117
Highly Cited.
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.
Gordon J Freeman, Jose M Casasnovas, Dale T Umetsu, Rosemarie H DeKruyff.
Immunol Rev, 2010 Jun 12; 235(1). PMID: 20536563    Free PMC article.
Highly Cited. Review.
Siglecs and immune regulation.
Shiv Pillai, Ilka Arun Netravali, Annaiah Cariappa, Hamid Mattoo.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224769    Free PMC article.
Highly Cited. Review.
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Norihiko Watanabe, Maya Gavrieli, +11 authors, Kenneth M Murphy.
Nat Immunol, 2003 Jun 11; 4(7). PMID: 12796776
Highly Cited.
Galectin expression profiling identifies galectin-1 and Galectin-9Δ5 as prognostic factors in stage I/II non-small cell lung cancer.
Iris A Schulkens, Roy Heusschen, +4 authors, Victor L Thijssen.
PLoS One, 2014 Sep 27; 9(9). PMID: 25259711    Free PMC article.
2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells.
Sebastian Stark, Carsten Watzl.
Int Immunol, 2006 Jan 18; 18(2). PMID: 16410313
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.
Julie Brahmer, Karen L Reckamp, +22 authors, David R Spigel.
N Engl J Med, 2015 Jun 02; 373(2). PMID: 26028407    Free PMC article.
Highly Cited.
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.
Matthew M Gubin, Xiuli Zhang, +24 authors, Robert D Schreiber.
Nature, 2014 Nov 28; 515(7528). PMID: 25428507    Free PMC article.
Highly Cited.
Pembrolizumab for the treatment of non-small-cell lung cancer.
Edward B Garon, Naiyer A Rizvi, +25 authors, KEYNOTE-001 Investigators.
N Engl J Med, 2015 Apr 22; 372(21). PMID: 25891174
Highly Cited.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.
Peter Attia, Giao Q Phan, +14 authors, Steven A Rosenberg.
J Clin Oncol, 2005 Aug 10; 23(25). PMID: 16087944    Free PMC article.
Highly Cited.
Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective.
Dung T Le, Elizabeth M Jaffee.
Cancer Res, 2012 Jul 05; 72(14). PMID: 22761338    Free PMC article.
Highly Cited. Review.
Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients.
P Salven, A Orpana, L Teerenhovi, H Joensuu.
Blood, 2000 Nov 23; 96(12). PMID: 11090051
Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.
Diane Tseng, Jens-Peter Volkmer, +8 authors, Irving L Weissman.
Proc Natl Acad Sci U S A, 2013 May 22; 110(27). PMID: 23690610    Free PMC article.
Highly Cited.
Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells.
Magis Mandapathil, Benedict Hilldorfer, +7 authors, Theresa L Whiteside.
J Biol Chem, 2009 Oct 28; 285(10). PMID: 19858205    Free PMC article.
Highly Cited.
Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis.
Chang-Ping Wu, Jing-Ting Jiang, +6 authors, Xue-Guang Zhang.
World J Gastroenterol, 2006 Feb 21; 12(3). PMID: 16489649    Free PMC article.
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.
Hyun-Tak Jin, Ana C Anderson, +6 authors, Rafi Ahmed.
Proc Natl Acad Sci U S A, 2010 Aug 04; 107(33). PMID: 20679213    Free PMC article.
Highly Cited.
CD155/PVR plays a key role in cell motility during tumor cell invasion and migration.
Kevin E Sloan, Brenda K Eustace, +8 authors, Daniel G Jay.
BMC Cancer, 2004 Oct 09; 4. PMID: 15471548    Free PMC article.
A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors.
Hatem H Soliman, Erica Jackson, +9 authors, Scott Antonia.
Oncotarget, 2014 Oct 21; 5(18). PMID: 25327557    Free PMC article.
Highly Cited.
Tumor immunosurveillance in human cancers.
Bernhard Mlecnik, Gabriela Bindea, Franck Pagès, Jérôme Galon.
Cancer Metastasis Rev, 2011 Jan 21; 30(1). PMID: 21249426    Free PMC article.
Review.
Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial.
F Stephen Hodi, Sandra Lee, +7 authors, John M Kirkwood.
JAMA, 2014 Nov 05; 312(17). PMID: 25369488    Free PMC article.
Highly Cited.
A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma.
Chrystelle Brignone, Bernard Escudier, +2 authors, Frédéric Triebel.
Clin Cancer Res, 2009 Sep 17; 15(19). PMID: 19755389
Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer.
Martin Loos, Dennis M Hedderich, +5 authors, Helmut Friess.
BMC Cancer, 2009 Dec 29; 9. PMID: 20035626    Free PMC article.
Immune responses in 4-1BB (CD137)-deficient mice.
Byoung S Kwon, Jose C Hurtado, +7 authors, Dass S Vinay.
J Immunol, 2002 May 23; 168(11). PMID: 12023342
VEGF as a mediator of tumor-associated immunodeficiency.
J E Ohm, D P Carbone.
Immunol Res, 2001 Jul 11; 23(2-3). PMID: 11444391
Review.
Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma.
Brian I Rini, Mark Stein, +7 authors, Michael Gordon.
Cancer, 2010 Oct 06; 117(4). PMID: 20922784
HLA-binding properties of tumor neoepitopes in humans.
Edward F Fritsch, Mohini Rajasagi, +3 authors, Catherine J Wu.
Cancer Immunol Res, 2014 Jun 05; 2(6). PMID: 24894089    Free PMC article.
Highly Cited. Review.
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.
Janis M Taube, Alison Klein, +7 authors, Robert A Anders.
Clin Cancer Res, 2014 Apr 10; 20(19). PMID: 24714771    Free PMC article.
Highly Cited.
Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.
Natalia Martin-Orozco, Yufeng Li, +5 authors, Laszlo Radvanyi.
Cancer Res, 2010 Nov 26; 70(23). PMID: 21098714    Free PMC article.
Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment.
Alfred Zippelius, Jens Schreiner, Petra Herzig, Philipp Müller.
Cancer Immunol Res, 2015 Jan 28; 3(3). PMID: 25623164
BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activation.
Thang Nguyen, Xikui K Liu, Yongliang Zhang, Chen Dong.
J Immunol, 2006 Jun 06; 176(12). PMID: 16751379    Free PMC article.
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Junzo Hamanishi, Masaki Mandai, +9 authors, Shingo Fujii.
Proc Natl Acad Sci U S A, 2007 Mar 16; 104(9). PMID: 17360651    Free PMC article.
Highly Cited.
B7-H4 overexpression in ovarian tumors.
Barbara Tringler, Wenhui Liu, +7 authors, Kenneth R Shroyer.
Gynecol Oncol, 2005 Nov 01; 100(1). PMID: 16256178
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
J J McIntire, S E Umetsu, +6 authors, R H DeKruyff.
Nat Immunol, 2001 Nov 29; 2(12). PMID: 11725301
Highly Cited.
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Janis M Taube, Robert A Anders, +8 authors, Lieping Chen.
Sci Transl Med, 2012 Mar 31; 4(127). PMID: 22461641    Free PMC article.
Highly Cited.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
Highly Cited.
MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy.
James Finke, Jennifer Ko, +3 authors, Peter Cohen.
Int Immunopharmacol, 2011 Feb 15; 11(7). PMID: 21315783    Free PMC article.
Highly Cited.
B7-h4 expression in human melanoma: its association with patients' survival and antitumor immune response.
Dagmar Quandt, Eckhard Fiedler, +2 authors, Barbara Seliger.
Clin Cancer Res, 2011 Mar 08; 17(10). PMID: 21378130
Systemic Agonistic Anti-CD40 Treatment of Tumor-Bearing Mice Modulates Hepatic Myeloid-Suppressive Cells and Causes Immune-Mediated Liver Damage.
José Medina-Echeverz, Chi Ma, +5 authors, Tim F Greten.
Cancer Immunol Res, 2015 Feb 01; 3(5). PMID: 25637366    Free PMC article.
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.
A A Hurwitz, B A Foster, +5 authors, J P Allison.
Cancer Res, 2000 May 16; 60(9). PMID: 10811122
Highly Cited.
CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator.
Guifang Cai, Anukanth Anumanthan, +3 authors, Gordon J Freeman.
Nat Immunol, 2008 Jan 15; 9(2). PMID: 18193050
Highly Cited.
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs.
Lei Lu, Xiaobing Xu, +3 authors, Xuan Wang.
J Transl Med, 2014 Feb 08; 12. PMID: 24502656    Free PMC article.
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Haidong Dong, Scott E Strome, +10 authors, Lieping Chen.
Nat Med, 2002 Jul 02; 8(8). PMID: 12091876
Highly Cited.
Immunologic correlates of the abscopal effect in a patient with melanoma.
Michael A Postow, Margaret K Callahan, +18 authors, Jedd D Wolchok.
N Engl J Med, 2012 Mar 09; 366(10). PMID: 22397654    Free PMC article.
Highly Cited.
Mechanisms of costimulation.
Arlene H Sharpe.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426211    Free PMC article.
Highly Cited. Review.
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.
Julie Vincent, Grégoire Mignot, +7 authors, François Ghiringhelli.
Cancer Res, 2010 Apr 15; 70(8). PMID: 20388795
Highly Cited.
Vitiligo in patients with metastatic melanoma: a good prognostic sign.
J J Nordlund, J M Kirkwood, +3 authors, A B Lerner.
J Am Acad Dermatol, 1983 Nov 01; 9(5). PMID: 6643767
Highly Cited.
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.
M K Jenkins, R H Schwartz.
J Exp Med, 1987 Feb 01; 165(2). PMID: 3029267    Free PMC article.
Highly Cited.
Inhibition of interleukin-2-induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2-associated side effects.
J W Mier, G Vachino, +6 authors, M B Atkins.
Blood, 1990 Nov 15; 76(10). PMID: 2242421
12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy?
Jane L Messina, David A Fenstermacher, +7 authors, James J Mulé.
Sci Rep, 2012 Oct 26; 2. PMID: 23097687    Free PMC article.
Highly Cited.
Therapeutic vaccines for cancer: an overview of clinical trials.
Ignacio Melero, Gustav Gaudernack, +8 authors, Håkan Mellstedt.
Nat Rev Clin Oncol, 2014 Jul 09; 11(9). PMID: 25001465
Highly Cited. Review.
B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival.
Amy E Krambeck, R Houston Thompson, +7 authors, Eugene D Kwon.
Proc Natl Acad Sci U S A, 2006 Jun 27; 103(27). PMID: 16798883    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Role of LAG-3 in regulatory T cells.
Ching-Tai Huang, Creg J Workman, +11 authors, Dario A A Vignali.
Immunity, 2004 Oct 16; 21(4). PMID: 15485628
Highly Cited.
Immunosurveillance and therapy of multiple myeloma are CD226 dependent.
Camille Guillerey, Lucas Ferrari de Andrade, +12 authors, Ludovic Martinet.
J Clin Invest, 2015 Apr 22; 125(5). PMID: 25893601    Free PMC article.
T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination.
Taylor H Schreiber, Dietlinde Wolf, +2 authors, Eckhard R Podack.
J Immunol, 2012 Sep 08; 189(7). PMID: 22956587    Free PMC article.
Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model.
Raffaella Iannone, Lucio Miele, +2 authors, Silvana Morello.
Am J Cancer Res, 2014 Mar 25; 4(2). PMID: 24660106    Free PMC article.
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human.
Claudia Bossen, Karine Ingold, +6 authors, Pascal Schneider.
J Biol Chem, 2006 Mar 21; 281(20). PMID: 16547002
Highly Cited.
Immunobiology of TNFSF15 and TNFRSF25.
Taylor H Schreiber, Eckhard R Podack.
Immunol Res, 2013 Nov 19; 57(1-3). PMID: 24242819
Review.
The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.
Jason P Twohig, Morgan Marsden, +6 authors, Eddie C Y Wang.
FASEB J, 2012 May 18; 26(8). PMID: 22593543    Free PMC article.
Prognostic significance of hypopigmentation in malignant melanoma.
J C Bystryn, D Rigel, R J Friedman, A Kopf.
Arch Dermatol, 1987 Aug 01; 123(8). PMID: 3631983
TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer.
Neil E Bhola, Justin M Balko, +6 authors, Carlos L Arteaga.
J Clin Invest, 2013 Feb 09; 123(3). PMID: 23391723    Free PMC article.
Highly Cited.
Prerequisites for the antitumor vaccine-like effect of chemotherapy and radiotherapy.
Dalil Hannani, Antonella Sistigu, +3 authors, Laurence Zitvogel.
Cancer J, 2011 Sep 29; 17(5). PMID: 21952286
Review.
OX40 is a potent immune-stimulating target in late-stage cancer patients.
Brendan D Curti, Magdalena Kovacsovics-Bankowski, +20 authors, Andrew D Weinberg.
Cancer Res, 2013 Nov 02; 73(24). PMID: 24177180    Free PMC article.
Highly Cited.
Pharma Success in Product Development—Does Biotechnology Change the Paradigm in Product Development and Attrition.
Ronald P Evens.
AAPS J, 2015 Oct 18; 18(1). PMID: 26475480    Free PMC article.
Combination cancer immunotherapies tailored to the tumour microenvironment.
Mark J Smyth, Shin Foong Ngiow, Antoni Ribas, Michele W L Teng.
Nat Rev Clin Oncol, 2015 Nov 26; 13(3). PMID: 26598942
Highly Cited. Review.
The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism.
Hua Yang, Craig M Brackett, +9 authors, Hans E Grossniklaus.
Oncotarget, 2015 Dec 15; 7(3). PMID: 26655090    Free PMC article.
Current progress in immunotherapy for pancreatic cancer.
Kelly Foley, Victoria Kim, Elizabeth Jaffee, Lei Zheng.
Cancer Lett, 2016 Jan 03; 381(1). PMID: 26723878    Free PMC article.
Highly Cited. Review.
Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
Michael C Cavalier, Mohd Imran Ansari, +12 authors, David J Weber.
J Med Chem, 2016 Jan 05; 59(2). PMID: 26727270    Free PMC article.
Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18.
Silvia Carvalho, Francesca Levi-Schaffer, Michael Sela, Yosef Yarden.
Br J Pharmacol, 2016 Feb 03; 173(9). PMID: 26833433    Free PMC article.
Review.
Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation.
A D Garg, E Romano, N Rufo, P Agostinis.
Cell Death Differ, 2016 Feb 20; 23(6). PMID: 26891691    Free PMC article.
Review.
Significance of Programmed Death Ligand 1 (PD-L1) Immunohistochemical Expression in Colorectal Cancer.
Lisha Wang, Fei Ren, +7 authors, Liang Cheng.
Mol Diagn Ther, 2016 Feb 20; 20(2). PMID: 26891728
Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression.
Ying Zhang, Hildegund C J Ertl.
Front Immunol, 2016 Feb 24; 7. PMID: 26904023    Free PMC article.
Review.
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer.
R B Birge, S Boeltz, +13 authors, M Herrmann.
Cell Death Differ, 2016 Feb 27; 23(6). PMID: 26915293    Free PMC article.
Highly Cited. Review.
Hepatocellular carcinoma cell sensitivity to Vγ9Vδ2 T lymphocyte-mediated killing is increased by zoledronate.
Shiori Sugai, Toshiaki Yoshikawa, +8 authors, Tetsuya Nakatsura.
Int J Oncol, 2016 Mar 05; 48(5). PMID: 26936487    Free PMC article.
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.
Weiping Zou, Jedd D Wolchok, Lieping Chen.
Sci Transl Med, 2016 Mar 05; 8(328). PMID: 26936508    Free PMC article.
Highly Cited. Review.
Combining BRAF inhibitor and anti PD-L1 antibody dramatically improves tumor regression and anti tumor immunity in an immunocompetent murine model of anaplastic thyroid cancer.
Eran Brauner, Viswanath Gunda, +6 authors, Sareh Parangi.
Oncotarget, 2016 Mar 05; 7(13). PMID: 26943572    Free PMC article.
Prognostic value of perioperative leukocyte count in resectable gastric cancer.
Xiao-Feng Chen, Jing Qian, +14 authors, Yong-Qian Shu.
World J Gastroenterol, 2016 Mar 15; 22(9). PMID: 26973420    Free PMC article.
Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination.
Tammy Oth, Joris Vanderlocht, +2 authors, Wilfred T V Germeraad.
Mediators Inflamm, 2016 Mar 17; 2016. PMID: 26980946    Free PMC article.
Review.
Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects.
Yelei Guo, Yao Wang, Weidong Han.
J Immunol Res, 2016 Mar 22; 2016. PMID: 26998495    Free PMC article.
Review.
Randomized Phase 2 Trial of the Oncolytic Virus Pelareorep (Reolysin) in Upfront Treatment of Metastatic Pancreatic Adenocarcinoma.
Anne M Noonan, Matthew R Farren, +17 authors, Tanios S Bekaii-Saab.
Mol Ther, 2016 Apr 05; 24(6). PMID: 27039845    Free PMC article.
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies.
Christian H K Lehmann, Lukas Heger, +4 authors, Diana Dudziak.
Vaccines (Basel), 2016 Apr 05; 4(2). PMID: 27043640    Free PMC article.
Review.
Prognostic role of high B7-H4 expression in patients with solid tumors: a meta-analysis.
Xing Song, Yingjie Shao, +4 authors, Jingting Jiang.
Oncotarget, 2016 Apr 09; 7(47). PMID: 27058425    Free PMC article.
Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction.
Paul C McDonald, Shawn C Chafe, Shoukat Dedhar.
Front Cell Dev Biol, 2016 Apr 12; 4. PMID: 27066484    Free PMC article.
Review.
Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
Krzysztof M Zak, Przemyslaw Grudnik, +5 authors, Tad A Holak.
Oncotarget, 2016 Apr 16; 7(21). PMID: 27083005    Free PMC article.
Highly Cited.
Durable antitumor responses to CD47 blockade require adaptive immune stimulation.
Jonathan T Sockolosky, Michael Dougan, +5 authors, K Christopher Garcia.
Proc Natl Acad Sci U S A, 2016 Apr 20; 113(19). PMID: 27091975    Free PMC article.
Highly Cited.
Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion.
Bram G Sengers, Sean McGinty, +6 authors, Armin Sepp.
MAbs, 2016 Apr 21; 8(5). PMID: 27097222    Free PMC article.
Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.
Karla D Passalacqua, Marie-Eve Charbonneau, +7 authors, Christiane E Wobus.
Antimicrob Agents Chemother, 2016 May 04; 60(7). PMID: 27139470    Free PMC article.
Myeloid cells in the tumor microenvironment: Role of adenosine.
Silvana Morello, Aldo Pinto, Corrado Blandizzi, Luca Antonioli.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141365    Free PMC article.
Review.
Cancer immunotherapy: the beginning of the end of cancer?
Sofia Farkona, Eleftherios P Diamandis, Ivan M Blasutig.
BMC Med, 2016 May 07; 14. PMID: 27151159    Free PMC article.
Highly Cited. Review.
Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer.
Mikio Kajihara, Kazuki Takakura, +6 authors, Shigeo Koido.
World J Gastroenterol, 2016 May 18; 22(18). PMID: 27182156    Free PMC article.
Review.
Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity.
Hidetoshi Nakagawa, Jessica M Sido, +3 authors, Hye-Jung Kim.
Proc Natl Acad Sci U S A, 2016 May 18; 113(22). PMID: 27185917    Free PMC article.
Emerging nanotechnologies for cancer immunotherapy.
Sourabh Shukla, Nicole F Steinmetz.
Exp Biol Med (Maywood), 2016 May 18; 241(10). PMID: 27190253    Free PMC article.
Review.
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Ana C Anderson, Nicole Joller, Vijay K Kuchroo.
Immunity, 2016 May 19; 44(5). PMID: 27192565    Free PMC article.
Highly Cited. Review.
Introduction to a review series on advances in cell-based immune therapeutics in hematology.
Catherine M Bollard, Freda K Stevenson.
Blood, 2016 May 22; 127(26). PMID: 27207803    Free PMC article.
Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types.
Giosuè Scognamiglio, Anna De Chiara, +8 authors, Gerardo Botti.
Int J Mol Sci, 2016 May 24; 17(5). PMID: 27213372    Free PMC article.
Dendritic-Tumor Fusion Cell-Based Cancer Vaccines.
Shigeo Koido.
Int J Mol Sci, 2016 May 31; 17(6). PMID: 27240347    Free PMC article.
Review.
FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).
Masaru Katoh.
Int J Mol Med, 2016 Jun 02; 38(1). PMID: 27245147    Free PMC article.
Highly Cited. Review.
A second chance for telomerase reverse transcriptase in anticancer immunotherapy.
Maurizio Zanetti.
Nat Rev Clin Oncol, 2016 Nov 03; 14(2). PMID: 27245281
Review.
Checkpoint inhibitors and other novel immunotherapies for advanced renal cell carcinoma.
Maria I Carlo, Martin H Voss, Robert J Motzer.
Nat Rev Urol, 2016 Jun 22; 13(7). PMID: 27324121    Free PMC article.
Review.
Immune checkpoint inhibitor combinations in solid tumors: opportunities and challenges.
Chrisann Kyi, Michael A Postow.
Immunotherapy, 2016 Jun 29; 8(7). PMID: 27349981    Free PMC article.
Highly Cited. Review.
Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy.
Bracha Shraibman, Dganit Melamed Kadosh, Eilon Barnea, Arie Admon.
Mol Cell Proteomics, 2016 Jul 15; 15(9). PMID: 27412690    Free PMC article.
Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication.
Gang An, Chirag Acharya, +7 authors, Kenneth C Anderson.
Blood, 2016 Jul 16; 128(12). PMID: 27418644    Free PMC article.
Highly Cited.
Advances in immunotherapy for melanoma management.
Mohammed Dany, Rose Nganga, +3 authors, Dirk Elston.
Hum Vaccin Immunother, 2016 Jul 28; 12(10). PMID: 27454404    Free PMC article.
Review.
Immuno-oncology combinations: raising the tail of the survival curve.
Samuel J Harris, Jessica Brown, Juanita Lopez, Timothy A Yap.
Cancer Biol Med, 2016 Jul 28; 13(2). PMID: 27458526    Free PMC article.
Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents.
Natalie J Serkova, S Gail Eckhardt.
Front Oncol, 2016 Jul 30; 6. PMID: 27471678    Free PMC article.
Review.
The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.
Nicole E Scharping, Ashley V Menk, +5 authors, Greg M Delgoffe.
Immunity, 2016 Aug 09; 45(2). PMID: 27496732    Free PMC article.
Highly Cited.
Current Progress in Immunotherapy for the Treatment of Biliary Cancers.
James M Pauff, Laura W Goff.
J Gastrointest Cancer, 2016 Aug 20; 47(4). PMID: 27538880
Review.
Autophagy- An emerging target for melanoma therapy.
Abibatou Ndoye, Ashani T Weeraratna.
F1000Res, 2016 Sep 02; 5. PMID: 27583134    Free PMC article.
Review.
Identification of candidate anti-cancer molecular mechanisms of Compound Kushen Injection using functional genomics.
Zhipeng Qu, Jian Cui, +5 authors, David L Adelson.
Oncotarget, 2016 Sep 08; 7(40). PMID: 27602759    Free PMC article.
Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity.
Fernando Souza-Fonseca-Guimaraes, Stephen J Blake, +3 authors, Mark J Smyth.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622048    Free PMC article.
Immunology: Channelling potassium to fight cancer.
K George Chandy, Raymond S Norton.
Nature, 2016 Sep 15; 537(7621). PMID: 27626384
BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression.
Hengrui Zhu, Fee Bengsch, +8 authors, Rugang Zhang.
Cell Rep, 2016 Sep 15; 16(11). PMID: 27626654    Free PMC article.
Highly Cited.
"Threshold-crossing": A Useful Way to Establish the Counterfactual in Clinical Trials?
H-G Eichler, B Bloechl-Daum, +14 authors, F Koenig.
Clin Pharmacol Ther, 2016 Oct 26; 100(6). PMID: 27650716    Free PMC article.
Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination.
Anke Redeker, Ramon Arens.
Front Immunol, 2016 Sep 23; 7. PMID: 27656185    Free PMC article.
Review.
Local delivery of checkpoints antibodies.
Chao Wang, Yanqi Ye, Zhen Gu.
Hum Vaccin Immunother, 2016 Sep 27; 13(1). PMID: 27668759    Free PMC article.
Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer.
Ken Takai, Annie Le, Valerie M Weaver, Zena Werb.
Oncotarget, 2016 Oct 21; 7(50). PMID: 27756881    Free PMC article.
Omics approaches to individual variation: modeling networks and the virtual patient.
Hans Lehrach.
Dialogues Clin Neurosci, 2016 Oct 21; 18(3). PMID: 27757060    Free PMC article.
High-dose irradiation in combination with toll-like receptor 9 agonist CpG oligodeoxynucleotide 7909 downregulates PD-L1 expression via the NF-κB signaling pathway in non-small cell lung cancer cells.
Xue Chen, Qi Zhang, +4 authors, Tiankui Qiao.
Onco Targets Ther, 2016 Nov 02; 9. PMID: 27799798    Free PMC article.
Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies.
Shuguang Tan, Danqing Chen, +9 authors, George F Gao.
Protein Cell, 2016 Nov 07; 7(12). PMID: 27815822    Free PMC article.
Review.
Targeting Immune Regulatory Networks to Counteract Immune Suppression in Cancer.
Chiara Camisaschi, Viviana Vallacchi, +10 authors, Veronica Huber.
Vaccines (Basel), 2016 Nov 10; 4(4). PMID: 27827921    Free PMC article.
Review.
Promoter methylation of the immune checkpoint receptor PD-1 (PDCD1) is an independent prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy.
Diane Goltz, Heidrun Gevensleben, +4 authors, Dimo Dietrich.
Oncoimmunology, 2016 Nov 18; 5(10). PMID: 27853645    Free PMC article.
In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.
Yu-Ling Lin, Nu-Man Tsai, +9 authors, Ru Chih C Huang.
Proc Natl Acad Sci U S A, 2016 Nov 20; 113(48). PMID: 27856749    Free PMC article.
Recent Advances of Light-Mediated Theranostics.
Xiangzhao Ai, Jing Mu, Bengang Xing.
Theranostics, 2016 Nov 24; 6(13). PMID: 27877246    Free PMC article.
Review.
A covalent antagonist for the human adenosine A2A receptor.
Xue Yang, Guo Dong, +4 authors, Ad P IJzerman.
Purinergic Signal, 2016 Dec 05; 13(2). PMID: 27915383    Free PMC article.
Targeting of interleukin (IL)-17A inhibits PDL1 expression in tumor cells and induces anticancer immunity in an estrogen receptor-negative murine model of breast cancer.
Yun-Feng Ma, Chen Chen, +4 authors, Jiru Xu.
Oncotarget, 2016 Dec 10; 8(5). PMID: 27935862    Free PMC article.
Role of Fc-FcγR interactions in the antitumor activity of therapeutic antibodies.
Bryan C Barnhart, Michael Quigley.
Immunol Cell Biol, 2016 Dec 16; 95(4). PMID: 27974746
Review.
Immunomodulatory and Antitumor Effects of a Novel TLR7 Agonist Combined with Lapatinib.
Ningning Gao, Jingjing Zhong, +7 authors, Guangyi Jin.
Sci Rep, 2016 Dec 22; 6. PMID: 28000738    Free PMC article.
Combining vasculature disrupting agent and Toll-like receptor 7/8 agonist for cancer therapy.
Anushree Seth, Hyunseung Lee, +6 authors, Kwan Soo Hong.
Oncotarget, 2016 Dec 31; 8(3). PMID: 28036266    Free PMC article.
Prognostic impact of immune microenvironment in laryngeal and pharyngeal squamous cell carcinoma: Immune cell subtypes, immuno-suppressive pathways and clinicopathologic characteristics.
Georgia Karpathiou, Francois Casteillo, +7 authors, Michel Peoc'h.
Oncotarget, 2016 Dec 31; 8(12). PMID: 28038471    Free PMC article.
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.
Kenji Chamoto, Partha S Chowdhury, +4 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2017 Jan 18; 114(5). PMID: 28096382    Free PMC article.
Highly Cited.
Monocytic myeloid-derived suppressor cells as a potent suppressor of tumor immunity in non-small cell lung cancer.
Katarzyna Pogoda, Maria Pyszniak, Paweł Rybojad, Jacek Tabarkiewicz.
Oncol Lett, 2017 Jan 20; 12(6). PMID: 28101225    Free PMC article.
Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies.
Alberto Ocana, Atanasio Pandiella.
Oncotarget, 2017 Jan 22; 8(13). PMID: 28108739    Free PMC article.
Review.
New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone.
Siwen Hu-Lieskovan, Antoni Ribas.
Cancer J, 2017 Jan 24; 23(1). PMID: 28114250    Free PMC article.
Review.
Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade.
Nina Eissler, Yumeng Mao, +5 authors, Per Kogner.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123870    Free PMC article.
Clinical implication of tumor-associated and immunological parameters in melanoma patients treated with ipilimumab.
V Damuzzo, S Solito, +6 authors, S Mandruzzato.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123888    Free PMC article.
BTLA identifies dysfunctional PD-1-expressing CD4+ T cells in human hepatocellular carcinoma.
Qiyi Zhao, Zhan-Lian Huang, +2 authors, Dong-Ming Kuang.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123898    Free PMC article.
Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis.
Shivan Sivakumar, Ines de Santiago, Leon Chlon, Florian Markowetz.
PLoS Med, 2017 Feb 01; 14(1). PMID: 28141826    Free PMC article.
The Principles of Engineering Immune Cells to Treat Cancer.
Wendell A Lim, Carl H June.
Cell, 2017 Feb 12; 168(4). PMID: 28187291    Free PMC article.
Highly Cited. Review.
Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy.
Qi Zhang, Bo Zhu, Yongsheng Li.
Front Immunol, 2017 Feb 18; 8. PMID: 28210259    Free PMC article.
Review.
Armed Oncolytic Adenovirus-Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors.
Kiyonori Tanoue, Amanda Rosewell Shaw, +5 authors, Masataka Suzuki.
Cancer Res, 2017 Feb 27; 77(8). PMID: 28235763    Free PMC article.
Highly Cited.
Macrophage regulation of B cell proliferation.
Naomi Goldman, Kornelija Valiuskyte, +3 authors, James E Riggs.
Cell Immunol, 2017 Feb 28; 314. PMID: 28238361    Free PMC article.
The Unique Molecular and Cellular Microenvironment of Ovarian Cancer.
Thomas Worzfeld, Elke Pogge von Strandmann, +4 authors, Rolf Müller.
Front Oncol, 2017 Mar 10; 7. PMID: 28275576    Free PMC article.
Highly Cited. Review.
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.
Vikram R Juneja, Kathleen A McGuire, +5 authors, Arlene H Sharpe.
J Exp Med, 2017 Mar 18; 214(4). PMID: 28302645    Free PMC article.
Highly Cited.
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma.
Jennifer D Moy, Jessica M Moskovitz, Robert L Ferris.
Eur J Cancer, 2017 Mar 23; 76. PMID: 28324750    Free PMC article.
Review.
Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers.
Erik S Knudsen, Paris Vail, +9 authors, Agnieszka K Witkiewicz.
Clin Cancer Res, 2017 Mar 30; 23(15). PMID: 28348045    Free PMC article.
Highly Cited.
The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Colleen S Netherby, Michelle N Messmer, +6 authors, Scott I Abrams.
J Immunol, 2017 Mar 31; 198(10). PMID: 28356386    Free PMC article.
Shifting the balance of power? The combination of oncolytic virotherapy and immune checkpoint blockade for glioblastoma treatment.
Sean E Lawler.
Neuro Oncol, 2017 Apr 06; 19(4). PMID: 28379450    Free PMC article.
Resistance to immunotherapy: clouds in a bright sky.
Gérard Milano.
Invest New Drugs, 2017 Apr 13; 35(5). PMID: 28401366
Review.
Breaking the crosstalk of the cellular tumorigenic network: Hypothesis for addressing resistances to targeted therapies in advanced NSCLC.
Stefan Langhammer, Joachim Scheerer.
Oncotarget, 2017 Apr 14; 8(26). PMID: 28402937    Free PMC article.
Review.
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Elizabeth Allen, Arnaud Jabouille, +8 authors, Gabriele Bergers.
Sci Transl Med, 2017 Apr 14; 9(385). PMID: 28404866    Free PMC article.
Highly Cited.
Neem leaf glycoprotein prevents post-surgical sarcoma recurrence in Swiss mice by differentially regulating cytotoxic T and myeloid-derived suppressor cells.
Madhurima Sarkar, Sarbari Ghosh, +6 authors, Rathindranath Baral.
PLoS One, 2017 Apr 18; 12(4). PMID: 28414726    Free PMC article.
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.
Melita Irving, Romain Vuillefroy de Silly, +2 authors, George Coukos.
Front Immunol, 2017 Apr 20; 8. PMID: 28421069    Free PMC article.
Review.
Update on Programmed Death-1 and Programmed Death-Ligand 1 Inhibition in the Treatment of Advanced or Metastatic Non-Small Cell Lung Cancer.
Marco A J Iafolla, Rosalyn A Juergens.
Front Oncol, 2017 Apr 22; 7. PMID: 28428947    Free PMC article.
Review.
Global survey of the immunomodulatory potential of common drugs.
Gregory I Vladimer, Berend Snijder, +13 authors, Giulio Superti-Furga.
Nat Chem Biol, 2017 Apr 25; 13(6). PMID: 28437395    Free PMC article.
Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector.
Quan Liu, Yijun Yang, +8 authors, Xiaoping Chen.
Oncotarget, 2017 Apr 28; 8(15). PMID: 28445973    Free PMC article.
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy.
Sean P Arlauckas, Christopher S Garris, +9 authors, Mikael J Pittet.
Sci Transl Med, 2017 May 12; 9(389). PMID: 28490665    Free PMC article.
Highly Cited.
Immune checkpoints on innate lymphoid cells.
Laura Chiossone, Eric Vivier.
J Exp Med, 2017 May 19; 214(6). PMID: 28515074    Free PMC article.
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.
Hwei-Fang Tsai, Ping-Ning Hsu.
J Biomed Sci, 2017 May 27; 24(1). PMID: 28545567    Free PMC article.
Review.
Quantitative Mass Spectrometry Analysis of PD-L1 Protein Expression, N-glycosylation and Expression Stoichiometry with PD-1 and PD-L2 in Human Melanoma.
Carlos A Morales-Betanzos, Hyoungjoo Lee, +4 authors, Daniel C Liebler.
Mol Cell Proteomics, 2017 May 27; 16(10). PMID: 28546465    Free PMC article.
Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules.
Kai-Bin Li, Na Li, +5 authors, He Tian.
Chem Sci, 2017 Jun 02; 7(10). PMID: 28567244    Free PMC article.
Cellular and molecular targets for the immunotherapy of hepatocellular carcinoma.
Vikrant Rai, Joe Abdo, +3 authors, Devendra K Agrawal.
Mol Cell Biochem, 2017 Jun 09; 437(1-2). PMID: 28593566
Review.
Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses.
Marta Spodzieja, Sławomir Lach, +8 authors, Sylwia Rodziewicz-Motowidło.
PLoS One, 2017 Jun 09; 12(6). PMID: 28594868    Free PMC article.
Highlights lecture EANM 2016: "Embracing molecular imaging and multi-modal imaging: a smart move for nuclear medicine towards personalized medicine".
Eric O Aboagye, Françoise Kraeber-Bodéré.
Eur J Nucl Med Mol Imaging, 2017 Jun 10; 44(9). PMID: 28597119    Free PMC article.
Review.
Pembrolizumab in cervical cancer: latest evidence and clinical usefulness.
Edith Borcoman, Christophe Le Tourneau.
Ther Adv Med Oncol, 2017 Jun 14; 9(6). PMID: 28607581    Free PMC article.
Review.
Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells.
Tihana Tršan, Kristina Vuković, +8 authors, Stipan Jonjić.
Eur J Immunol, 2017 Jun 15; 47(8). PMID: 28612942    Free PMC article.
New insights into the role of EMT in tumor immune escape.
Stéphane Terry, Pierre Savagner, +4 authors, Salem Chouaib.
Mol Oncol, 2017 Jun 15; 11(7). PMID: 28614624    Free PMC article.
Highly Cited. Review.
Immune Checkpoints as a Target for Colorectal Cancer Treatment.
Alessandro Passardi, Matteo Canale, Martina Valgiusti, Paola Ulivi.
Int J Mol Sci, 2017 Jun 22; 18(6). PMID: 28635639    Free PMC article.
Review.
[Prospect and Current Situation of Immune Checkpoint Inhibitors 
in First-line Treatment in Advanced Non-small Cell Lung Cancer Patients].
Haiyang Wang, Xiaoqing Yu, Yun Fan.
Zhongguo Fei Ai Za Zhi, 2017 Jun 24; 20(6). PMID: 28641702    Free PMC article.
Review.
Immunotherapy and Targeted Therapy for Small Cell Lung Cancer: There Is Hope.
Jonathan M Lehman, Mary E Gwin, Pierre P Massion.
Curr Oncol Rep, 2017 Jun 24; 19(7). PMID: 28643173
Review.
Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies.
A G M Mostofa, Md Kamal Hossain, Debasish Basak, Muhammad Shahdaat Bin Sayeed.
Front Pharmacol, 2017 Jul 01; 8. PMID: 28659794    Free PMC article.
Review.
Molecular Dissection of CD8+ T-Cell Dysfunction.
Chao Wang, Meromit Singer, Ana C Anderson.
Trends Immunol, 2017 Jul 01; 38(8). PMID: 28662970    Free PMC article.
Review.
Atezolizumab for the treatment of non-small cell lung cancer.
Fernando C Santini, Charles M Rudin.
Expert Rev Clin Pharmacol, 2017 Jul 18; 10(9). PMID: 28714780    Free PMC article.
Review.
Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment.
Olumide Babajide Gbolahan, Amer M Zeidan, +4 authors, Heiko Konig.
Int J Mol Sci, 2017 Aug 02; 18(8). PMID: 28758974    Free PMC article.
Review.
Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy.
Rajeev Shrimali, Shamim Ahmad, +7 authors, Samir N Khleif.
J Immunother Cancer, 2017 Aug 16; 5(1). PMID: 28807056    Free PMC article.
CEACAM1 as a multi-purpose target for cancer immunotherapy.
Matthew Dankner, Scott D Gray-Owen, +2 authors, Nicole Beauchemin.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811966    Free PMC article.
Review.
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.
Marian L Burr, Christina E Sparbier, +21 authors, Mark A Dawson.
Nature, 2017 Aug 17; 549(7670). PMID: 28813417    Free PMC article.
Highly Cited.
mTOR co-targeting strategies for head and neck cancer therapy.
Zhiyong Wang, Juan Callejas Valera, +2 authors, J Silvio Gutkind.
Cancer Metastasis Rev, 2017 Aug 20; 36(3). PMID: 28822012    Free PMC article.
Review.
A Dynamic Metabolic Flux Analysis of Myeloid-Derived Suppressor Cells Confirms Immunosuppression-Related Metabolic Plasticity.
Guillaume Goffaux, Iness Hammami, Mario Jolicoeur.
Sci Rep, 2017 Aug 31; 7(1). PMID: 28852166    Free PMC article.
Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.
Andrew M Donson, John Apps, +19 authors, Advancing Treatment for Pediatric Craniopharyngioma Consortium.
J Neuropathol Exp Neurol, 2017 Sep 02; 76(9). PMID: 28859336    Free PMC article.
Tumour radiosensitivity is associated with immune activation in solid tumours.
Tobin Strom, Louis B Harrison, +11 authors, Javier F Torres-Roca.
Eur J Cancer, 2017 Sep 02; 84. PMID: 28863385    Free PMC article.
PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome.
Hashem O Alsaab, Samaresh Sau, +4 authors, Arun K Iyer.
Front Pharmacol, 2017 Sep 08; 8. PMID: 28878676    Free PMC article.
Highly Cited. Review.
Identification of a HLA-A*0201-restricted immunogenic epitope from the universal tumor antigen DEPDC1.
Anna Tosi, Silvia Dalla Santa, +6 authors, Antonio Rosato.
Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28919988    Free PMC article.
Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.
Pearl Bakhru, Meng-Lei Zhu, +14 authors, Maureen A Su.
JCI Insight, 2017 Sep 22; 2(18). PMID: 28931755    Free PMC article.
Nanomaterials for cancer immunotherapy.
Wantong Song, Sara N Musetti, Leaf Huang.
Biomaterials, 2017 Sep 30; 148. PMID: 28961532    Free PMC article.
Review.
Integrated analysis profiles of long non-coding RNAs reveal potential biomarkers of drug resistance in lung cancer.
Wenhua Xue, Lifeng Li, +10 authors, Jie Zhao.
Oncotarget, 2017 Oct 04; 8(38). PMID: 28968955    Free PMC article.
miR-217 inhibits laryngeal cancer metastasis by repressing AEG-1 and PD-L1 expression.
Susheng Miao, Xionghui Mao, +11 authors, Ji Sun.
Oncotarget, 2017 Oct 06; 8(37). PMID: 28977933    Free PMC article.
Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies.
Mengnan He, Yan Chai, +6 authors, George F Gao.
Oncotarget, 2017 Oct 06; 8(40). PMID: 28978021    Free PMC article.
Tumor-targeted costimulation by using bi-specific aptamers.
Fernando Pastor.
Cancer Cell Microenviron, 2016 Jun 06; 3. PMID: 28989946    Free PMC article.
How many diseases is triple negative breast cancer: the protagonism of the immune microenvironment.
Diana P Saraiva, M Guadalupe Cabral, António Jacinto, Sofia Braga.
ESMO Open, 2017 Oct 12; 2(4). PMID: 29018573    Free PMC article.
Review.
Apigenin in cancer therapy: anti-cancer effects and mechanisms of action.
Xiaohui Yan, Miao Qi, +2 authors, Huanjie Shao.
Cell Biosci, 2017 Oct 17; 7. PMID: 29034071    Free PMC article.
Review.
Genomic insights into head and neck cancer.
Tim N Beck, Erica A Golemis.
Cancers Head Neck, 2016 Jan 01; 1. PMID: 29034103    Free PMC article.
Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy.
Lior Nissim, Ming-Ru Wu, +7 authors, Timothy K Lu.
Cell, 2017 Oct 24; 171(5). PMID: 29056342    Free PMC article.
Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
Lukasz Skalniak, Krzysztof M Zak, +12 authors, Tad A Holak.
Oncotarget, 2017 Oct 27; 8(42). PMID: 29069777    Free PMC article.
Chemo-Immunotherapy Using Lentinan for the Treatment of Gastric Cancer with Liver Metastases.
Kenji Ina, Ryuichi Furuta, +3 authors, Masahiko Yoneda.
Med Sci (Basel), 2016 Apr 07; 4(2). PMID: 29083372    Free PMC article.
CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.
Jiehui Deng, Eric S Wang, +44 authors, Kwok-Kin Wong.
Cancer Discov, 2017 Nov 05; 8(2). PMID: 29101163    Free PMC article.
Highly Cited.
CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy.
Anna Wasiuk, James Testa, +9 authors, Li-Zhen He.
J Immunol, 2017 Nov 08; 199(12). PMID: 29109120    Free PMC article.
Strategies for Bispecific Single Chain Antibody in Cancer Immunotherapy.
Shu-Juan Zhou, Jia Wei, +3 authors, Bao-Rui Liu.
J Cancer, 2017 Nov 21; 8(18). PMID: 29151956    Free PMC article.
Review.
Evaluation of two high-throughput proteomic technologies for plasma biomarker discovery in immunotherapy-treated melanoma patients.
Su Yin Lim, Jenny H Lee, +9 authors, Helen Rizos.
Biomark Res, 2017 Nov 21; 5. PMID: 29152306    Free PMC article.
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Jinfang Zhang, Xia Bu, +15 authors, Wenyi Wei.
Nature, 2017 Nov 22; 553(7686). PMID: 29160310    Free PMC article.
Highly Cited.
Future cancer research priorities in the USA: a Lancet Oncology Commission.
Elizabeth M Jaffee, Chi Van Dang, +51 authors, Alfred Yung.
Lancet Oncol, 2017 Dec 07; 18(11). PMID: 29208398    Free PMC article.
Review.
Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications.
Mariona Cabo, Rienk Offringa, +3 authors, Lorenzo Galluzzi.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209572    Free PMC article.
Review.
Molecular Biomarkers of Primary and Acquired Resistance to T-Cell-Mediated Immunotherapy in Cancer: Landscape, Clinical Implications, and Future Directions.
Young Kwang Chae, Michael S Oh, Francis J Giles.
Oncologist, 2017 Dec 16; 23(4). PMID: 29242279    Free PMC article.
Review.
Therapy for Cancer: Strategy of Combining Anti-Angiogenic and Target Therapies.
Valentina Comunanza, Federico Bussolino.
Front Cell Dev Biol, 2017 Dec 23; 5. PMID: 29270405    Free PMC article.
Review.
The dawn of vaccines for cancer prevention.
Olivera J Finn.
Nat Rev Immunol, 2017 Dec 28; 18(3). PMID: 29279613
Highly Cited. Review.
Inhibition of PI4K IIIα radiosensitizes in human tumor xenograft and immune-competent syngeneic murine tumor model.
Younghee Park, Ji Min Park, +2 authors, In Ah Kim.
Oncotarget, 2018 Jan 05; 8(66). PMID: 29299156    Free PMC article.
Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy.
Neus Martinez-Bosch, Judith Vinaixa, Pilar Navarro.
Cancers (Basel), 2018 Jan 06; 10(1). PMID: 29301364    Free PMC article.
Highly Cited. Review.
High macrophage PD-L1 expression not responsible for T cell suppression.
Naomi Goldman, Yelizavet D Lomakova, +4 authors, James E Riggs.
Cell Immunol, 2018 Jan 07; 324. PMID: 29305065    Free PMC article.
New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness.
Isabel Corraliza-Gorjón, Beatriz Somovilla-Crespo, +2 authors, Leonor Kremer.
Front Immunol, 2018 Jan 10; 8. PMID: 29312320    Free PMC article.
Review.
Engineering nanoparticles to overcome barriers to immunotherapy.
Randall Toy, Krishnendu Roy.
Bioeng Transl Med, 2016 Jun 20; 1(1). PMID: 29313006    Free PMC article.
Review.
Mechanisms of resistance to immune checkpoint inhibitors.
Russell W Jenkins, David A Barbie, Keith T Flaherty.
Br J Cancer, 2018 Jan 11; 118(1). PMID: 29319049    Free PMC article.
Highly Cited. Review.
Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas.
Qianxing Mo, Fotis Nikolos, +6 authors, Keith Syson Chan.
J Natl Cancer Inst, 2018 Jan 18; 110(5). PMID: 29342309    Free PMC article.
PD-1/PD-L1 Axis in Lung Cancer.
Fernando C Santini, Matthew D Hellmann.
Cancer J, 2018 Jan 24; 24(1). PMID: 29360723    Free PMC article.
Review.
Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T.
Dok Hyun Yoon, Mark J Osborn, Jakub Tolar, Chong Jai Kim.
Int J Mol Sci, 2018 Jan 25; 19(2). PMID: 29364163    Free PMC article.
Highly Cited. Review.
[Cancer patients in operative intensive care medicine].
T Annecke, A Hohn, B Böll, M Kochanek.
Anaesthesist, 2018 Jan 26; 67(2). PMID: 29368008    Free PMC article.
Review.
ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance.
Joseph R Podojil, Iris Hecht, +6 authors, Stephen D Miller.
J Immunol, 2018 Feb 13; 200(6). PMID: 29431690    Free PMC article.
Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung.
Takuya Ueda, Keiju Aokage, +13 authors, Genichiro Ishii.
J Cancer Res Clin Oncol, 2018 Feb 13; 144(5). PMID: 29435735
Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection.
Scott Balsitis, Volodymyr Gali, +16 authors, Daniel J Tenney.
PLoS One, 2018 Feb 15; 13(2). PMID: 29444087    Free PMC article.
Importance of immune monitoring approaches and the use of immune checkpoints for the treatment of diffuse intrinsic pontine glioma: From bench to clinic and vice versa (Review).
Jorge Augusto Borin Scutti.
Int J Oncol, 2018 Feb 28; 52(4). PMID: 29484440    Free PMC article.
Review.
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.
Franz L Ricklefs, Quazim Alayo, +26 authors, E Antonio Chiocca.
Sci Adv, 2018 Mar 14; 4(3). PMID: 29532035    Free PMC article.
Highly Cited.
Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein.
Michael D Oberst, Catherine Augé, +19 authors, Scott A Hammond.
Mol Cancer Ther, 2018 Mar 17; 17(5). PMID: 29545330    Free PMC article.
Kinase inhibitors: the road ahead.
Fleur M Ferguson, Nathanael S Gray.
Nat Rev Drug Discov, 2018 Mar 17; 17(5). PMID: 29545548
Highly Cited. Review.
Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts.
Linda Ziani, Salem Chouaib, Jerome Thiery.
Front Immunol, 2018 Mar 17; 9. PMID: 29545811    Free PMC article.
Highly Cited. Review.
Efficacy of PD-1/PD-L1 inhibitors against pretreated advanced cancer: a systematic review and meta-analysis.
Hao Hu, Qian Zhu, +3 authors, Chang Ying Guo.
Oncotarget, 2018 Mar 17; 9(14). PMID: 29545941    Free PMC article.
Immunotherapy in pancreatic adenocarcinoma-overcoming barriers to response.
Ari Rosenberg, Devalingam Mahalingam.
J Gastrointest Oncol, 2018 Mar 23; 9(1). PMID: 29564181    Free PMC article.
Review.
Immunotherapy combination strategies (non-chemotherapy) in non-small cell lung cancer.
Sandrine Niyongere, Andreas Saltos, Jhanelle E Gray.
J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593889    Free PMC article.
Review.
Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells.
Jonathan Powell, Filipa Mota, +23 authors, David L Selwood.
J Med Chem, 2018 Apr 13; 61(9). PMID: 29648813    Free PMC article.
TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.
Heng-Jia Liu, Patrick H Lizotte, +8 authors, Elizabeth P Henske.
JCI Insight, 2018 Apr 20; 3(8). PMID: 29669930    Free PMC article.
Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
Victoria Klepsch, Natascha Hermann-Kleiter, +12 authors, Gottfried Baier.
Nat Commun, 2018 Apr 20; 9(1). PMID: 29670099    Free PMC article.
A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy.
Yu Mi, Christof C Smith, +5 authors, Andrew Z Wang.
Adv Mater, 2018 Apr 25; 30(25). PMID: 29691900    Free PMC article.
Noninvasive PET Imaging of T cells.
Weijun Wei, Dawei Jiang, +2 authors, Weibo Cai.
Trends Cancer, 2018 May 02; 4(5). PMID: 29709260    Free PMC article.
Review.
Novel Effector Phenotype of Tim-3+ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients.
Zhuqing Liu, Elizabeth L McMichael, +6 authors, Robert L Ferris.
Clin Cancer Res, 2018 May 02; 24(18). PMID: 29712685    Free PMC article.
VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma.
Ming Zhang, Hua-Jin Pang, +4 authors, Xiao-Feng He.
BMC Cancer, 2018 May 04; 18(1). PMID: 29720116    Free PMC article.
A Convergence-Based Framework for Cancer Drug Resistance.
David J Konieczkowski, Cory M Johannessen, Levi A Garraway.
Cancer Cell, 2018 May 16; 33(5). PMID: 29763622    Free PMC article.
Highly Cited. Review.
STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.
Jung-Mao Hsu, Weiya Xia, +14 authors, Mien-Chie Hung.
Nat Commun, 2018 May 17; 9(1). PMID: 29765039    Free PMC article.
Highly Cited.
A case of drug-induced Graves' Orbitopathy after combination therapy with Tremelimumab and Durvalumab.
E Sabini, A Sframeli, M Marinò.
J Endocrinol Invest, 2018 May 29; 41(7). PMID: 29804271
Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?
Marc Hilmi, Laurent Bartholin, Cindy Neuzillet.
World J Gastroenterol, 2018 Jun 02; 24(20). PMID: 29853732    Free PMC article.
Highly Cited. Review.
Diagnostic value of peripheral blood immune profiling in colorectal cancer.
Joungbum Choi, Hyung Gun Maeng, +12 authors, Jong Kyun Lee.
Ann Surg Treat Res, 2018 Jun 02; 94(6). PMID: 29854709    Free PMC article.
Tumor immunotherapy: New aspects of natural killer cells.
Yangxi Li, Rui Sun.
Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861604    Free PMC article.
Is there a room for immune checkpoint inhibitors in early stage non-small cell lung cancer?
Elisa Gobbini, Matteo Giaj Levra.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951294    Free PMC article.
Review.
Endocrine, Sexual Function, and Infertility Side Effects of Immune Checkpoint Inhibitor Therapy for Genitourinary Cancers.
Akshay Sood, Daniel Cole, +5 authors, Shaheen Alanee.
Curr Urol Rep, 2018 Jul 05; 19(9). PMID: 29971696
Review.
Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity.
Jiu-Cheng Zhang, Wei-Dong Chen, +6 authors, Hua Zhu.
Acta Pharmacol Sin, 2018 Jul 12; 39(11). PMID: 29991709    Free PMC article.
Review.
Massive parallel screening of phage libraries for the generation of repertoires of human immunomodulatory monoclonal antibodies.
Emanuele Sasso, Chiara D'Avino, +9 authors, Claudia De Lorenzo.
MAbs, 2018 Jul 12; 10(7). PMID: 29995563    Free PMC article.
Tumor microenvironment participates in metastasis of pancreatic cancer.
Bo Ren, Ming Cui, +4 authors, Yupei Zhao.
Mol Cancer, 2018 Aug 01; 17(1). PMID: 30060755    Free PMC article.
Highly Cited. Review.
Emerging strategies for combination checkpoint modulators in cancer immunotherapy.
Aleksandra Popovic, Elizabeth M Jaffee, Neeha Zaidi.
J Clin Invest, 2018 Aug 02; 128(8). PMID: 30067248    Free PMC article.
Highly Cited. Review.
DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.
Varun Sasidharan Nair, Salman M Toor, +2 authors, Eyad Elkord.
Clin Epigenetics, 2018 Aug 08; 10(1). PMID: 30081950    Free PMC article.
Checkpoint blockade-based immunotherapy in the context of tumor microenvironment: Opportunities and challenges.
Jingjing Duan, Yu Wang, Shunchang Jiao.
Cancer Med, 2018 Aug 09; 7(9). PMID: 30088347    Free PMC article.
Review.
The HU177 Collagen Epitope Controls Melanoma Cell Migration and Experimental Metastasis by a CDK5/YAP-Dependent Mechanism.
Jennifer M Caron, XiangHua Han, +2 authors, Peter C Brooks.
Am J Pathol, 2018 Aug 18; 188(10). PMID: 30118657    Free PMC article.
CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers.
Chiara Tuccilli, Enke Baldini, +13 authors, Salvatore Ulisse.
Int J Endocrinol, 2018 Aug 21; 2018. PMID: 30123257    Free PMC article.
The Role of Toll-Like Receptor in Inflammation and Tumor Immunity.
Xiaohong Cen, Shuwen Liu, Kui Cheng.
Front Pharmacol, 2018 Aug 22; 9. PMID: 30127747    Free PMC article.
Highly Cited. Review.
Interaction of PVR/PVRL2 with TIGIT/DNAM-1 as a novel immune checkpoint axis and therapeutic target in cancer.
Hauke Stamm, Jasmin Wellbrock, Walter Fiedler.
Mamm Genome, 2018 Aug 23; 29(11-12). PMID: 30132062
Review.
3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade.
Amir R Aref, Marco Campisi, +20 authors, Russell W Jenkins.
Lab Chip, 2018 Sep 06; 18(20). PMID: 30183789    Free PMC article.
Immuno-Oncology: Emerging Targets and Combination Therapies.
Henry T Marshall, Mustafa B A Djamgoz.
Front Oncol, 2018 Sep 08; 8. PMID: 30191140    Free PMC article.
Highly Cited. Review.
Cytokine-induced killer cell/dendritic cell-cytokine-induced killer cell immunotherapy for the postoperative treatment of gastric cancer: A systematic review and meta-analysis.
Xiang Wang, Song Tang, +5 authors, Yumin Li.
Medicine (Baltimore), 2018 Sep 12; 97(36). PMID: 30200148    Free PMC article.
Systematic Review.
The Molecular Imaging of Natural Killer Cells.
Mariya Shapovalova, Sean R Pyper, Branden S Moriarity, Aaron M LeBeau.
Mol Imaging, 2018 Sep 12; 17. PMID: 30203710    Free PMC article.
Review.
Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors.
Mario M Soldevilla, Helena Villanueva, +6 authors, Fernando Pastor.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221041    Free PMC article.
Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans.
Sina Fellermeier-Kopf, Friederike Gieseke, +3 authors, Roland E Kontermann.
Oncoimmunology, 2018 Sep 20; 7(9). PMID: 30228940    Free PMC article.
PEG-L-CHOP treatment is safe and effective in adult extranodal NK/T-cell lymphoma with a low rate of clinical hypersensitivity.
Wen Zheng, Yuhuan Gao, +14 authors, Jun Zhu.
BMC Cancer, 2018 Sep 23; 18(1). PMID: 30241515    Free PMC article.
Cancer Immunotherapy in Diffuse Large B-Cell Lymphoma.
Jun Zhang, L Jeffrey Medeiros, Ken H Young.
Front Oncol, 2018 Sep 27; 8. PMID: 30250823    Free PMC article.
Review.
Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy.
Jinfang Zhang, Fabin Dang, Junming Ren, Wenyi Wei.
Trends Biochem Sci, 2018 Oct 06; 43(12). PMID: 30287140    Free PMC article.
Review.
Combination with SGT-53 overcomes tumor resistance to a checkpoint inhibitor.
Sang-Soo Kim, Joe B Harford, +2 authors, Esther H Chang.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288347    Free PMC article.
Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences.
Xinyu Yan, Shouyue Zhang, +3 authors, Heng Xu.
Front Pharmacol, 2018 Oct 09; 9. PMID: 30294272    Free PMC article.
Review.
Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade.
Jun Gong, Andrew Hendifar, +5 authors, Ravi Salgia.
Clin Transl Med, 2018 Oct 09; 7(1). PMID: 30294755    Free PMC article.
Review.
Oncolytic Viruses Partner With T-Cell Therapy for Solid Tumor Treatment.
Amanda Rosewell Shaw, Masataka Suzuki.
Front Immunol, 2018 Oct 10; 9. PMID: 30298067    Free PMC article.
Review.
Durvalumab in NSCLC: latest evidence and clinical potential.
Nerea Muñoz-Unceta, Isabel Burgueño, Elizabeth Jiménez, Luis Paz-Ares.
Ther Adv Med Oncol, 2018 Oct 23; 10. PMID: 30344651    Free PMC article.
Review.
Predictive biomarkers for tumor immune checkpoint blockade.
Mengting Tong, Jing Wang, +4 authors, Hongliang Zhang.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349382    Free PMC article.
Review.
[Mode of action, new targets and potential biomarkers in modern immunotherapy].
J Bedke, V Stühler, T Todenhöfer, A Stenzl.
Urologe A, 2018 Oct 24; 57(11). PMID: 30350128
Review.
Metabolic reprogramming by Dichloroacetic acid potentiates photodynamic therapy of human breast adenocarcinoma MCF-7 cells.
Zeiyad Alkarakooly, Qudes A Al-Anbaky, Krishnaswamy Kannan, Nawab Ali.
PLoS One, 2018 Oct 24; 13(10). PMID: 30352078    Free PMC article.
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma.
Alessandra Lopes, Kevin Vanvarenberg, +5 authors, Gaëlle Vandermeulen.
Sci Rep, 2018 Oct 26; 8(1). PMID: 30356111    Free PMC article.
Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again.
Samantha L Bucktrout, Jeffrey A Bluestone, Fred Ramsdell.
Genome Med, 2018 Nov 01; 10(1). PMID: 30376867    Free PMC article.
Review.
Cancer immunotherapy using PolyPurine Reverse Hoogsteen hairpins targeting the PD-1/PD-L1 pathway in human tumor cells.
Miriam Marlene Medina Enríquez, Alex J Félix, Carlos J Ciudad, Véronique Noé.
PLoS One, 2018 Nov 07; 13(11). PMID: 30399174    Free PMC article.
Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives.
Jessica Marinello, Maria Delcuratolo, Giovanni Capranico.
Int J Mol Sci, 2018 Nov 09; 19(11). PMID: 30404148    Free PMC article.
Review.
MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells.
Babita Agrawal, Nancy Gupta, Jeffrey D Konowalchuk.
Front Immunol, 2018 Nov 09; 9. PMID: 30405607    Free PMC article.
Review.
Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents.
Yong Zhang, Yufen Zhao, +18 authors, Robert M Borzilleri.
ACS Med Chem Lett, 2018 Nov 16; 9(11). PMID: 30429955    Free PMC article.
Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium.
Luca Falzone, Salvatore Salomone, Massimo Libra.
Front Pharmacol, 2018 Nov 30; 9. PMID: 30483135    Free PMC article.
Highly Cited. Review.
Trial watch: Peptide-based vaccines in anticancer therapy.
Lucillia Bezu, Oliver Kepp, +6 authors, Lorenzo Galluzzi.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524907    Free PMC article.
Highly Cited. Review.
Integrating clinical, molecular, proteomic and histopathological data within the tissue context: tissunomics.
Santiago Ramón Y Cajal, Stefan Hümmer, +5 authors, Javier Hernandez-Losa.
Histopathology, 2019 Jan 23; 75(1). PMID: 30667539    Free PMC article.
Review.
A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma.
Sang-Soo Kim, Joe B Harford, +3 authors, Esther H Chang.
Int J Cancer, 2019 Jun 27; 145(9). PMID: 31241175    Free PMC article.
ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity.
Mario Martínez Soldevilla, Helena Villanueva, +10 authors, Fernando Pastor.
Mol Ther, 2019 Aug 14; 27(11). PMID: 31405808    Free PMC article.
Molecular Modeling Studies on the Binding Mode of the PD-1/PD-L1 Complex Inhibitors.
Suliman Almahmoud, Haizhen A Zhong.
Int J Mol Sci, 2019 Sep 25; 20(18). PMID: 31546905    Free PMC article.
Targeting tumor-resident mast cells for effective anti-melanoma immune responses.
Susanne Kaesler, Florian Wölbing, +15 authors, Tilo Biedermann.
JCI Insight, 2019 Oct 04; 4(19). PMID: 31578309    Free PMC article.
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Youg Raj Thaker, Monika Raab, Klaus Strebhardt, Christopher E Rudd.
Nat Commun, 2019 Oct 24; 10(1). PMID: 31641113    Free PMC article.
pTuneos: prioritizing tumor neoantigens from next-generation sequencing data.
Chi Zhou, Zhiting Wei, +8 authors, Qi Liu.
Genome Med, 2019 Nov 02; 11(1). PMID: 31666118    Free PMC article.
A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer.
Xi Li, Rouzheng Wang, +25 authors, Tao Dong.
Front Oncol, 2019 Nov 12; 9. PMID: 31709176    Free PMC article.
EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma.
Gang Xiao, Li-Lian Jin, +8 authors, Limin Zheng.
J Immunother Cancer, 2019 Nov 16; 7(1). PMID: 31727135    Free PMC article.
Mitochondria-Targeting Immunogenic Cell Death Inducer Improves the Adoptive T-Cell Therapy Against Solid Tumor.
Qingzhi Jiang, Chi Zhang, +5 authors, Chunmeng Shi.
Front Oncol, 2019 Nov 30; 9. PMID: 31781498    Free PMC article.
Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance.
Dayana B Rivadeneira, Kristin DePeaux, +9 authors, Greg M Delgoffe.
Immunity, 2019 Sep 01; 51(3). PMID: 31471106    Free PMC article.
4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth.
Subhankar Panda, Nirmalya Pradhan, +6 authors, Debasis Manna.
Sci Rep, 2019 Dec 06; 9(1). PMID: 31804586    Free PMC article.
Gut microbiome and CAR-T therapy.
Muhammad Bilal Abid, Nirav N Shah, Theresa C Maatman, Parameswaran N Hari.
Exp Hematol Oncol, 2019 Dec 13; 8. PMID: 31827982    Free PMC article.
Review.
Checkpoint Genes at the Cancer Side of the Immunological Synapse in Bladder Cancer.
Paula Dobosz, Przemysław A Stempor, +6 authors, Raya Leibowitz-Amit.
Transl Oncol, 2019 Dec 24; 13(2). PMID: 31869744    Free PMC article.
Tumour immune cell infiltration and survival after platinum-based chemotherapy in high-grade serous ovarian cancer subtypes: A gene expression-based computational study.
Rong Liu, Rong Hu, +2 authors, Hong-Hao Zhou.
EBioMedicine, 2020 Jan 09; 51. PMID: 31911269    Free PMC article.
Basis of PD1/PD-L1 Therapies.
Barbara Seliger.
J Clin Med, 2019 Dec 11; 8(12). PMID: 31817953    Free PMC article.
Review.
Immunosuppressive Tumor Microenvironment Status and Histological Grading of Endometrial Carcinoma.
Julie Antomarchi, Damien Ambrosetti, +6 authors, Heidy Schmid-Antomarchi.
Cancer Microenviron, 2019 May 28; 12(2-3). PMID: 31134527    Free PMC article.
Genomic Signatures of Immune Activation Predict Outcome in Advanced Stages of Ovarian Cancer and Basal-Like Breast Tumors.
Ana Alcaraz-Sanabria, Mariona Baliu-Piqué, +9 authors, Alberto Ocana.
Front Oncol, 2020 Jan 31; 9. PMID: 31998644    Free PMC article.
Beyond PD-L1 Markers for Lung Cancer Immunotherapy.
Kamila Wojas-Krawczyk, Ewa Kalinka, +2 authors, Janusz Milanowski.
Int J Mol Sci, 2019 Apr 21; 20(8). PMID: 31003463    Free PMC article.
Review.
The Novel Combination of Nitroxoline and PD-1 Blockade, Exerts a Potent Antitumor Effect in a Mouse Model of Prostate Cancer.
Naijin Xu, Linglong Huang, +9 authors, Peng Huang.
Int J Biol Sci, 2019 Jun 12; 15(5). PMID: 31182913    Free PMC article.
Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment.
Shanshan Deng, Michael J Clowers, +2 authors, Seyed Javad Moghaddam.
Front Oncol, 2020 Feb 11; 9. PMID: 32039025    Free PMC article.
Review.
Helper Innate Lymphoid Cells in Human Tumors: A Double-Edged Sword?
Nicola Tumino, Paola Vacca, +5 authors, Lorenzo Moretta.
Front Immunol, 2020 Feb 18; 10. PMID: 32063901    Free PMC article.
Review.
Single injection of IL-12 coacervate as an effective therapy against B16-F10 melanoma in mice.
Mintai P Hwang, Ronald J Fecek, +2 authors, Yadong Wang.
J Control Release, 2019 Dec 24; 318. PMID: 31866503    Free PMC article.
Immunotherapy for the Treatment of Breast Cancer: Emerging New Data.
Lida A Mina, Shannon Lim, Shakeela W Bahadur, Abdul T Firoz.
Breast Cancer (Dove Med Press), 2020 Feb 27; 11. PMID: 32099454    Free PMC article.
Review.
Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells.
Matthew B Dong, Guangchuan Wang, +17 authors, Sidi Chen.
Cell, 2019 Aug 24; 178(5). PMID: 31442407    Free PMC article.
Identification and characterization of an alternative cancer-derived PD-L1 splice variant.
Nadia B Hassounah, Venkat S Malladi, +10 authors, Esra A Akbay.
Cancer Immunol Immunother, 2018 Dec 20; 68(3). PMID: 30564890    Free PMC article.
Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment.
Esperanza R Matarredona, Angel M Pastor.
Cells, 2020 Jan 08; 9(1). PMID: 31906023    Free PMC article.
Review.
Theragnostic potentials of core/shell mesoporous silica nanostructures.
Aswathy Ravindran Girija, Sivakumar Balasubramanian.
Nanotheranostics, 2019 Jan 22; 3(1). PMID: 30662821    Free PMC article.
Review.
Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy.
Zaigang Zhou, Baoli Zhang, +4 authors, Jinhui Wu.
Proc Natl Acad Sci U S A, 2019 May 31; 116(24). PMID: 31142648    Free PMC article.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han.
J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595    Free PMC article.
Highly Cited. Review.
Extracellular vesicles: important collaborators in cancer progression.
Shinya Sato, Alissa M Weaver.
Essays Biochem, 2018 Apr 19; 62(2). PMID: 29666212    Free PMC article.
Review.
T-cell trafficking plays an essential role in tumor immunity.
Daniel J Aires, Masaru Yoshida, +10 authors, Thomas S Kupper.
Lab Invest, 2018 Oct 26; 99(1). PMID: 30353131    Free PMC article.
An update: emerging drugs to treat squamous cell carcinomas of the head and neck.
Yoon Se Lee, Daniel E Johnson, Jennifer R Grandis.
Expert Opin Emerg Drugs, 2018 Nov 01; 23(4). PMID: 30376740    Free PMC article.
Review.
Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.
M V Bais.
J Dent Res, 2019 Jan 08; 98(3). PMID: 30615537    Free PMC article.
Tumor-Targeted Chemoimmunotherapy with Immune-Checkpoint Blockade for Enhanced Anti-Melanoma Efficacy.
Man Li, Yuting Yang, +8 authors, Qin He.
AAPS J, 2019 Jan 13; 21(2). PMID: 30635795
Engineering Nanoparticles for Targeted Remodeling of the Tumor Microenvironment to Improve Cancer Immunotherapy.
Shan Gao, Dongjuan Yang, +6 authors, Kai Shi.
Theranostics, 2019 Jan 22; 9(1). PMID: 30662558    Free PMC article.
Highly Cited. Review.
The relationship between autophagy and the immune system and its applications for tumor immunotherapy.
Guan-Min Jiang, Yuan Tan, +7 authors, Hong Shan.
Mol Cancer, 2019 Jan 27; 18(1). PMID: 30678689    Free PMC article.
Highly Cited. Review.
Cold Tumors: A Therapeutic Challenge for Immunotherapy.
Paola Bonaventura, Tala Shekarian, +5 authors, Stéphane Depil.
Front Immunol, 2019 Feb 26; 10. PMID: 30800125    Free PMC article.
Highly Cited. Review.
Lymphopenia in Cancer Patients and its Effects on Response to Immunotherapy: an opportunity for combination with Cytokines?
Christine Ménétrier-Caux, Isabelle Ray-Coquard, Jean-Yves Blay, Christophe Caux.
J Immunother Cancer, 2019 Mar 30; 7(1). PMID: 30922400    Free PMC article.
Highly Cited. Review.
Feline XLF accumulates at DNA damage sites in a Ku-dependent manner.
Manabu Koike, Yasutomo Yutoku, Aki Koike.
FEBS Open Bio, 2019 May 23; 9(6). PMID: 31115163    Free PMC article.
A novel model of controlling PD-L1 expression in ALK+ anaplastic large cell lymphoma revealed by CRISPR screening.
Jing-Ping Zhang, Zhihui Song, +10 authors, Yibin Yang.
Blood, 2019 Jun 04; 134(2). PMID: 31151983    Free PMC article.
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
Li-Chuan Chan, Chia-Wei Li, +26 authors, Mien-Chie Hung.
J Clin Invest, 2019 Jul 16; 129(8). PMID: 31305264    Free PMC article.
Highly Cited.
Upregulation of PD-1 follows tumour development in the AOM/DSS model of inflammation-induced colorectal cancer in mice.
Mohammad Yassin, Zuzanna Sadowska, +4 authors, Anders Elm Pedersen.
Immunology, 2019 Aug 21; 158(1). PMID: 31429085    Free PMC article.
Unleashing Natural Killer Cells in the Tumor Microenvironment-The Next Generation of Immunotherapy?
Aviad Ben-Shmuel, Guy Biber, Mira Barda-Saad.
Front Immunol, 2020 Mar 11; 11. PMID: 32153582    Free PMC article.
Review.
Association of MSH2 Expression With Tumor Mutational Burden and the Immune Microenvironment in Lung Adenocarcinoma.
Mingming Jia, Linli Yao, Qin Yang, Tian Chi.
Front Oncol, 2020 Mar 11; 10. PMID: 32154170    Free PMC article.
Resistance Mechanisms and Barriers to Successful Immunotherapy for Treating Glioblastoma.
Jason Adhikaree, Julia Moreno-Vicente, +2 authors, Poulam M Patel.
Cells, 2020 Jan 25; 9(2). PMID: 31973059    Free PMC article.
Review.
FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity.
Wei Wu, Doudou Jing, +5 authors, Zengwu Shao.
Theranostics, 2020 Mar 21; 10(6). PMID: 32194840    Free PMC article.
Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8+ T-cell activation and exhaustion.
José Belizário, Maria Fernanda Destro Rodrigues.
Ther Adv Vaccines Immunother, 2020 Mar 25; 8. PMID: 32206744    Free PMC article.
Review.
Multifunctional phototheranostic nanomedicine for cancer imaging and treatment.
D Gao, X Guo, +7 authors, Z Yang.
Mater Today Bio, 2020 Mar 27; 5. PMID: 32211603    Free PMC article.
Review.
Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy.
Alok Kumar, Kenji Chamoto, Partha S Chowdhury, Tasuku Honjo.
Elife, 2020 Mar 04; 9. PMID: 32122466    Free PMC article.
Promises and pitfalls for recombinant oligoclonal antibodies-based therapeutics in cancer and infectious disease.
Davide Corti, Jeffrey D Kearns.
Curr Opin Immunol, 2016 Mar 21; 40. PMID: 26995095    Free PMC article.
Review.
Combinatorial Approaches With Checkpoint Inhibitors to Enhance Anti-tumor Immunity.
Barbara Seliger.
Front Immunol, 2019 Jun 11; 10. PMID: 31178856    Free PMC article.
Review.
PD-L1 Distribution and Perspective for Cancer Immunotherapy-Blockade, Knockdown, or Inhibition.
Yilun Wu, Weiyu Chen, Zhi Ping Xu, Wenyi Gu.
Front Immunol, 2019 Sep 12; 10. PMID: 31507611    Free PMC article.
Highly Cited. Review.
New Approaches on Cancer Immunotherapy.
Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, Mien-Chie Hung.
Cold Spring Harb Perspect Med, 2019 Oct 17; 10(8). PMID: 31615865    Free PMC article.
Review.
Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health.
Feixiong Cheng, Han Liang, +2 authors, Ruth Nussinov.
Pharmacol Rev, 2018 Dec 14; 71(1). PMID: 30545954    Free PMC article.
Review.
[Cancer patients in operative intensive care medicine].
Thorsten Annecke, Andreas Hohn, Boris Böll, Matthias Kochanek.
Wien Klin Mag, 2018 Jan 01; 21(2). PMID: 32288864    Free PMC article.
Review.
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Brendan T Parr, Richard Pastor, +27 authors, Yichin Liu.
ACS Med Chem Lett, 2020 Apr 16; 11(4). PMID: 32292562    Free PMC article.
Development of oncolytic virotherapy: from genetic modification to combination therapy.
Qiaoshuai Lan, Shuai Xia, +4 authors, Lu Lu.
Front Med, 2020 Mar 09; 14(2). PMID: 32146606    Free PMC article.
Review.
CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models.
Zhuangwei Lv, Ping Zhang, +8 authors, Yanhong Ji.
Oncoimmunology, 2020 May 05; 9(1). PMID: 32363119    Free PMC article.
Adenosine Metabolism: Emerging Concepts for Cancer Therapy.
Detlev Boison, Gennady G Yegutkin.
Cancer Cell, 2019 Dec 11; 36(6). PMID: 31821783    Free PMC article.
Review.
pH-Dependent Grafting of Cancer Cells with Antigenic Epitopes Promotes Selective Antibody-Mediated Cytotoxicity.
Janessa Wehr, Eden L Sikorski, +6 authors, Damien Thévenin.
J Med Chem, 2020 Mar 21; 63(7). PMID: 32196345    Free PMC article.
Soluble CD80 Protein Delays Tumor Growth and Promotes Tumor-Infiltrating Lymphocytes.
Lucas A Horn, Tiha M Long, +2 authors, Suzanne Ostrand-Rosenberg.
Cancer Immunol Res, 2017 Nov 11; 6(1). PMID: 29122838    Free PMC article.
Current Clinical Progress of PD-1/PD-L1 Immunotherapy and Potential Combination Treatment in Non-Small Cell Lung Cancer.
Jia-Xin Li, Ju-Min Huang, +4 authors, Pei-Yu Yan.
Integr Cancer Ther, 2019 Dec 17; 18. PMID: 31838881    Free PMC article.
Review.
Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo.
Gitte Holmen Olofsson, Agnete Witness Praest Jensen, Manja Idorn, Per Thor Straten.
Int J Mol Sci, 2020 May 31; 21(11). PMID: 32471301    Free PMC article.
Review.
Comprehensive Analysis of PD-1 Gene Expression, Immune Characteristics and Prognostic Significance in 1396 Glioma Patients.
Chaojun Liu, Zhen Zhang, +6 authors, Yi Zhang.
Cancer Manag Res, 2020 Jul 02; 12. PMID: 32606935    Free PMC article.
Dissecting the Tumor-Immune Landscape in Chimeric Antigen Receptor T-cell Therapy: Key Challenges and Opportunities for a Systems Immunology Approach.
Gregory M Chen, Andrew Azzam, +3 authors, Kai Tan.
Clin Cancer Res, 2020 Mar 05; 26(14). PMID: 32127393    Free PMC article.
Review.
Recombinant Costimulatory Fusion Proteins as Functional Immunomodulators Enhance Antitumor Activity in Murine B16F10 Melanoma.
Huaman Cai, Wenfang Wang, +4 authors, Rongxiu Li.
Vaccines (Basel), 2020 May 20; 8(2). PMID: 32423130    Free PMC article.
High-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions.
Soumaya Allouch, Ahmed Malki, +3 authors, Ala-Eddin Al Moustafa.
Front Oncol, 2020 Jul 23; 10. PMID: 32695664    Free PMC article.
Review.
Developments in therapy with monoclonal antibodies and related proteins.
H Michael Shepard, Gail Lewis Phillips, Christopher D Thanos, Marc Feldmann.
Clin Med (Lond), 2017 Jun 03; 17(3). PMID: 28572223    Free PMC article.
Review.
Combining Nanomedicine and Immunotherapy.
Yang Shi, Twan Lammers.
Acc Chem Res, 2019 May 24; 52(6). PMID: 31120725    Free PMC article.
Immunotherapies and Combination Strategies for Immuno-Oncology.
Cody Barbari, Tyler Fontaine, +4 authors, Rahul R Deshmukh.
Int J Mol Sci, 2020 Jul 19; 21(14). PMID: 32679922    Free PMC article.
Review.
Checkpoint Inhibitors and Engineered Cells: New Weapons for Natural Killer Cell Arsenal Against Hematological Malignancies.
Massimo Giuliani, Alessandro Poggi.
Cells, 2020 Jul 03; 9(7). PMID: 32610578    Free PMC article.
Review.
Competition NMR for Detection of Hit/Lead Inhibitors of Protein-Protein Interactions.
Bogdan Musielak, Weronika Janczyk, +4 authors, Tad Holak.
Molecules, 2020 Jul 08; 25(13). PMID: 32630327    Free PMC article.
Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model.
Doreen Lau, Fabien Garçon, +6 authors, Ferdia A Gallagher.
Front Immunol, 2020 Aug 15; 11. PMID: 32793206    Free PMC article.
Past, Present, and Future of Anticancer Nanomedicine.
Kyungeun Kim, Dongwoo Khang.
Int J Nanomedicine, 2020 Aug 22; 15. PMID: 32821098    Free PMC article.
Review.
Magnetic Iron Oxide Nanoparticles for Disease Detection and Therapy.
Sheng Tong, Haibao Zhu, Gang Bao.
Mater Today (Kidlington), 2020 Aug 25; 31. PMID: 32831620    Free PMC article.
Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy.
Lisa K Puntigam, Sandra S Jeske, +8 authors, Patrick J Schuler.
Int J Mol Sci, 2020 Jul 28; 21(15). PMID: 32707816    Free PMC article.
A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response.
Hao-Dong Li, Changzheng Lu, +15 authors, Diego H Castrillon.
JCI Insight, 2020 Jul 24; 5(14). PMID: 32699191    Free PMC article.
Novel cucurmosin-based immunotoxin targeting programmed cell death 1-ligand 1 with high potency against human tumor in vitro and in vivo.
Caiyun Zhang, Jiani Xiong, +5 authors, Jieming Xie.
Cancer Sci, 2020 Jun 27; 111(9). PMID: 32589330    Free PMC article.
Liposomal gp100 vaccine combined with CpG ODN sensitizes established B16F10 melanoma tumors to anti PD-1 therapy.
Mona Yazdani, Mahdi Hatamipour, +6 authors, Ali Badiee.
Iran J Basic Med Sci, 2020 Sep 22; 23(8). PMID: 32952954    Free PMC article.
Immunotherapy, Radiotherapy, and Hyperthermia: A Combined Therapeutic Approach in Pancreatic Cancer Treatment.
Javed Mahmood, Hem D Shukla, +6 authors, Zeljko Vujaskovic.
Cancers (Basel), 2018 Nov 30; 10(12). PMID: 30486519    Free PMC article.
Review.
Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases.
Krupa Naran, Trishana Nundalall, Shivan Chetty, Stefan Barth.
Front Microbiol, 2019 Jan 10; 9. PMID: 30622524    Free PMC article.
Review.
Incidence of Ipilimumab-Related Serious Adverse Events in Patients with Advanced Cancer: A Meta-Analysis.
Chang-Ying Guo, Si-Cong Jiang, Yu-Kang Kuang, Hao Hu.
J Cancer, 2019 Jan 22; 10(1). PMID: 30662532    Free PMC article.
The Risks and Benefits of Immune Checkpoint Blockade in Anti-AChR Antibody-Seropositive Non-Small Cell Lung Cancer Patients.
Koichi Saruwatari, Ryo Sato, +8 authors, Takuro Sakagami.
Cancers (Basel), 2019 Jan 27; 11(2). PMID: 30682845    Free PMC article.
Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors.
Renata Boldrini, Maria Debora De Pasquale, +11 authors, Doriana Fruci.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713803    Free PMC article.
VISTA/PD-1H: a potential target for non-small cell lung cancer immunotherapy.
Juan-Manuel Hernandez-Martinez, Edgar Vergara, +2 authors, Oscar Arrieta.
J Thorac Dis, 2019 Feb 13; 10(12). PMID: 30746169    Free PMC article.
Advances in immune checkpoint inhibitors for bone sarcoma therapy.
Pichaya Thanindratarn, Dylan C Dean, +2 authors, Zhenfeng Duan.
J Bone Oncol, 2019 Feb 19; 15. PMID: 30775238    Free PMC article.
Highly Cited. Review.
Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies.
Tiziana Annese, Roberto Tamma, Simona Ruggieri, Domenico Ribatti.
Cancers (Basel), 2019 Mar 21; 11(3). PMID: 30889903    Free PMC article.
Review.
Emerging Nano-/Microapproaches for Cancer Immunotherapy.
Yu Mi, C Tilden Hagan, Benjamin G Vincent, Andrew Z Wang.
Adv Sci (Weinh), 2019 Apr 03; 6(6). PMID: 30937265    Free PMC article.
Review.
Strategies to Improve Cancer Immune Checkpoint Inhibitors Efficacy, Other Than Abscopal Effect: A Systematic Review.
Vito Longo, Oronzo Brunetti, +4 authors, Nicola Silvestris.
Cancers (Basel), 2019 Apr 18; 11(4). PMID: 30991686    Free PMC article.
Review.
Immunophenotype of T Cells Expressing Programmed Death-1 and Cytotoxic T Cell Antigen-4 in Early Lung Cancer: Local vs. Systemic Immune Response.
Iwona Kwiecien, Tomasz Skirecki, +2 authors, Joanna Domagala-Kulawik.
Cancers (Basel), 2019 Apr 24; 11(4). PMID: 31010080    Free PMC article.
Unleashing Tumour-Dendritic Cells to Fight Cancer by Tackling Their Three A's: Abundance, Activation and Antigen-Delivery.
Aleksandar Murgaski, Pauline M R Bardet, +2 authors, Damya Laoui.
Cancers (Basel), 2019 May 17; 11(5). PMID: 31091774    Free PMC article.
Review.
The Role of Cardiac Magnetic Resonance Imaging to Detect Cardiac Toxicity From Cancer Therapeutics.
Aaron Soufer, Lauren A Baldassarre.
Curr Treat Options Cardiovasc Med, 2019 May 20; 21(6). PMID: 31104180
Review.
The Immune Checkpoint Regulator PDL1 is an Independent Prognostic Biomarker for Biochemical Recurrence in Prostate Cancer Patients Following Adjuvant Hormonal Therapy.
Heng Li, Zhize Wang, +11 authors, Zhangqun Ye.
J Cancer, 2019 Jul 11; 10(14). PMID: 31289580    Free PMC article.
DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy.
Elaine Gilmore, Nuala McCabe, Richard D Kennedy, Eileen E Parkes.
J Oncol, 2019 Jul 20; 2019. PMID: 31320901    Free PMC article.
Review.
Big Data Approaches for Modeling Response and Resistance to Cancer Drugs.
Peng Jiang, William R Sellers, X Shirley Liu.
Annu Rev Biomed Data Sci, 2019 Jul 26; 1. PMID: 31342013    Free PMC article.
Exceptional Responder to Immunotherapy: A Rare Case of Post-HSCT DLBCL Relapse Responding to Nivolumab.
Irappa Madabhavi, Sandeep Ks, Malay Sarkar, Mitul Modi.
Int J Hematol Oncol Stem Cell Res, 2019 Aug 03; 13(2). PMID: 31372200    Free PMC article.
DNA Methylation Biomarkers Predict Objective Responses to PD-1/PD-L1 Inhibition Blockade.
Gang Xue, Ze-Jia Cui, +9 authors, Jianghui Xiong.
Front Genet, 2019 Sep 03; 10. PMID: 31475034    Free PMC article.
The evolving immuno-oncology landscape in advanced lung cancer: first-line treatment of non-small cell lung cancer.
Jia Li Low, Robert J Walsh, +2 authors, Ross A Soo.
Ther Adv Med Oncol, 2019 Sep 10; 11. PMID: 31497071    Free PMC article.
Review.
Identifying the Most Effective Hydatid Cyst Fluid Fraction for Anticancer Vaccination of 4T1 Breast Tumor-Bearing Mice.
Shima Daneshpour, Shahla Rostamirad, +3 authors, Hossein Yousofi Darani.
Int J Prev Med, 2019 Sep 14; 10. PMID: 31516684    Free PMC article.
Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis.
Ane Ruiz-de-Angulo, Marc Bilbao-Asensio, +7 authors, Juan C Mareque-Rivas.
iScience, 2020 Sep 13; 23(9). PMID: 32919370    Free PMC article.
Rewiring Mitochondrial Metabolism for CD8+ T Cell Memory Formation and Effective Cancer Immunotherapy.
Wenhui Li, Lianjun Zhang.
Front Immunol, 2020 Sep 29; 11. PMID: 32983095    Free PMC article.
Review.
Charge and Size Dual Switchable Nanocage for Novel Triple-Interlocked Combination Therapy Pattern.
Rui Yang, Zipeng Zhang, +8 authors, Na Zhang.
Adv Sci (Weinh), 2020 Oct 02; 7(18). PMID: 32999836    Free PMC article.
The construction of a lymphoma cell-based, DC-targeted vaccine, and its application in lymphoma prevention and cure.
Tianlin Zhou, Jinrong Peng, +7 authors, Zhiyong Qian.
Bioact Mater, 2020 Oct 03; 6(3). PMID: 33005832    Free PMC article.
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
Francis S Willard, Jonathan D Douros, +15 authors, Kyle W Sloop.
JCI Insight, 2020 Jul 31; 5(17). PMID: 32730231    Free PMC article.
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.
Ivy X Chen, Kathleen Newcomer, +8 authors, Rakesh K Jain.
Proc Natl Acad Sci U S A, 2020 Sep 11; 117(38). PMID: 32907939    Free PMC article.
Mammalian Expression and In Situ Biotinylation of Extracellular Protein Targets for Directed Evolution.
Brian J Grindel, Brian J Engel, +5 authors, Steven W Millward.
ACS Omega, 2020 Oct 13; 5(39). PMID: 33043224    Free PMC article.
Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Magdalena Konieczny, Bogdan Musielak, +10 authors, Jacek Plewka.
J Med Chem, 2020 Sep 17; 63(19). PMID: 32936638    Free PMC article.
Antibody-Drug Conjugates: The Last Decade.
Nicolas Joubert, Alain Beck, Charles Dumontet, Caroline Denevault-Sabourin.
Pharmaceuticals (Basel), 2020 Sep 18; 13(9). PMID: 32937862    Free PMC article.
Review.
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers.
Leonard Kaps, Detlef Schuppan.
Cells, 2020 Sep 10; 9(9). PMID: 32899119    Free PMC article.
Review.
Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics.
Zhiqiang Chen, Yueming Qian, +5 authors, Zheng Jian Li.
MAbs, 2020 Oct 13; 12(1). PMID: 33044887    Free PMC article.
CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC).
Shiyi Liu, Feiyan Wang, +10 authors, Yanxiang Cheng.
Cancer Cell Int, 2020 Oct 30; 20. PMID: 33117084    Free PMC article.
Overexpression of Programmed Death-Ligand 1 Receptor mRNA as an Independent Negative Prognostic Factor for Triple Negative Breast Cancer.
Ibnu Purwanto, Didik Setyo Heriyanto, +4 authors, Sofia Mubarika Haryana.
World J Oncol, 2020 Oct 30; 11(5). PMID: 33117465    Free PMC article.
[Checkpoint inhibitors for cancer therapy].
Hilke Zander, Susanne Müller-Egert, +3 authors, Jörg Engelbergs.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2020 Oct 02; 63(11). PMID: 33001218    Free PMC article.
Review.
The Resistance Mechanisms of Lung Cancer Immunotherapy.
Fen Wang, Shubin Wang, Qing Zhou.
Front Oncol, 2020 Nov 17; 10. PMID: 33194652    Free PMC article.
Review.
Combinational immunotherapy based on immune checkpoints inhibitors in small cell lung cancer: is this the beginning to reverse the refractory situation?
Haoyue Guo, Yayi He, +7 authors, Caicun Zhou.
J Thorac Dis, 2020 Nov 20; 12(10). PMID: 33209440    Free PMC article.
Review.
KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression.
Xiao Albert Zhou, Jiadong Zhou, +13 authors, Jiadong Wang.
Proc Natl Acad Sci U S A, 2020 Oct 29; 117(45). PMID: 33109719    Free PMC article.
Nanomaterial-Based Tumor Photothermal Immunotherapy.
Peng Xu, Feng Liang.
Int J Nanomedicine, 2020 Nov 28; 15. PMID: 33244232    Free PMC article.
Review.
STAT3 Induces Immunosuppression by Upregulating PD-1/PD-L1 in HNSCC.
L L Bu, G T Yu, +7 authors, Z J Sun.
J Dent Res, 2017 Jun 13; 96(9). PMID: 28605599    Free PMC article.
Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Katarzyna Magiera-Mularz, Lukasz Skalniak, +11 authors, Tad A Holak.
Angew Chem Int Ed Engl, 2017 Sep 08; 56(44). PMID: 28881104    Free PMC article.
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response.
Peng Jiang, Shengqing Gu, +12 authors, X Shirley Liu.
Nat Med, 2018 Aug 22; 24(10). PMID: 30127393    Free PMC article.
Highly Cited.
Comprehensive molecular and immunological characterization of hepatocellular carcinoma.
Shu Shimada, Kaoru Mogushi, +12 authors, Shinji Tanaka.
EBioMedicine, 2019 Jan 02; 40. PMID: 30598371    Free PMC article.
Highly Cited.
Neuropilins in the Context of Tumor Vasculature.
Stephan Niland, Johannes A Eble.
Int J Mol Sci, 2019 Feb 06; 20(3). PMID: 30717262    Free PMC article.
Review.
Co-inhibitory T cell receptor KLRG1: human cancer expression and efficacy of neutralization in murine cancer models.
Steven A Greenberg, Sek Won Kong, Evan Thompson, Stefano V Gulla.
Oncotarget, 2019 Mar 13; 10(14). PMID: 30858925    Free PMC article.
Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.
Hongchuan Liu, Lijing Guo, +12 authors, Jinghua Yan.
MAbs, 2019 Mar 21; 11(4). PMID: 30892132    Free PMC article.
Risk of dermatologic and mucosal adverse events associated with PD-1/PD-L1 inhibitors in cancer patients: A meta-analysis of randomized controlled trials.
Wenwei Yang, Shuquan Li, Qingrui Yang.
Medicine (Baltimore), 2019 May 18; 98(20). PMID: 31096532    Free PMC article.
The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment.
Stephen G Gaffney, Elizabeth B Perry, +3 authors, Jeffrey P Townsend.
Oncotarget, 2019 Jul 31; 10(44). PMID: 31360302    Free PMC article.
Stability enhancement in a mAb and Fab coformulation.
Hongyu Zhang, Paul A Dalby.
Sci Rep, 2020 Dec 05; 10(1). PMID: 33273491    Free PMC article.
Overview of New Treatments with Immunotherapy for Breast Cancer and a Proposal of a Combination Therapy.
Miguel Angel Galván Morales, Raúl Barrera Rodríguez, Julio Raúl Santiago Cruz, Luis M Teran.
Molecules, 2020 Dec 06; 25(23). PMID: 33276556    Free PMC article.
Review.
RNA sequencing: new technologies and applications in cancer research.
Mingye Hong, Shuang Tao, +6 authors, Hua Zhang.
J Hematol Oncol, 2020 Dec 06; 13(1). PMID: 33276803    Free PMC article.
Review.
Genomic investigation of co-targeting tumor immune microenvironment and immune checkpoints in pan-cancer immunotherapy.
Xing Huang, Tianyu Tang, +5 authors, Tingbo Liang.
NPJ Precis Oncol, 2020 Dec 11; 4(1). PMID: 33299118    Free PMC article.
The importance of exosomal PDL1 in tumour immune evasion.
Dhouha Daassi, Kathleen M Mahoney, Gordon J Freeman.
Nat Rev Immunol, 2020 Jan 23; 20(4). PMID: 31965064
Review.
Comparative expression analysis of PD-1, PD-L1, and CD8A in lung adenocarcinoma.
Ke Ma, Yulei Qiao, Hao Wang, Shuai Wang.
Ann Transl Med, 2020 Dec 15; 8(22). PMID: 33313223    Free PMC article.
Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression - Implications for Cancer Therapy.
Silvina Odete Bustos, Fernanda Antunes, Maria Cristina Rangel, Roger Chammas.
Front Oncol, 2020 Dec 17; 10. PMID: 33324568    Free PMC article.
Review.
Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy.
Kazuhide Sato, Noriko Sato, +5 authors, Hisataka Kobayashi.
Sci Transl Med, 2016 Aug 19; 8(352). PMID: 27535621    Free PMC article.
Predictive value of tumor mutation burden (TMB) with targeted next-generation sequencing in immunocheckpoint inhibitors for non-small cell lung cancer (NSCLC).
Xiaoting Ma, Yujian Zhang, Shan Wang, Jing Yu.
J Cancer, 2021 Jan 05; 12(2). PMID: 33391454    Free PMC article.
The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy.
Anastasia Mpakali, Efstratios Stratikos.
Cancers (Basel), 2021 Jan 08; 13(1). PMID: 33406696    Free PMC article.
Review.
Nanoparticles as Smart Carriers for Enhanced Cancer Immunotherapy.
Neelam Thakur, Saloni Thakur, +2 authors, Parames C Sil.
Front Chem, 2021 Jan 08; 8. PMID: 33409265    Free PMC article.
Review.
Understanding and Managing Large B Cell Lymphoma Relapses after Chimeric Antigen Receptor T Cell Therapy.
Michael Byrne, Olalekan O Oluwole, +3 authors, Fredrick L Locke.
Biol Blood Marrow Transplant, 2019 Jul 08; 25(11). PMID: 31279751    Free PMC article.
Review.
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity.
Dan Lu, Liang Liu, +14 authors, Yuxin Yin.
Nat Immunol, 2020 Jan 15; 21(3). PMID: 31932812
Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response.
Adeline Raynaud, Klervi Desrumeaux, +5 authors, Brigitte Kerfelec.
Oncoimmunology, 2021 Jan 19; 10(1). PMID: 33457075    Free PMC article.
Immune checkpoint inhibitor (ICI) combination therapy compared to monotherapy in advanced solid cancer: A systematic review.
Xiaoting Ma, Yujian Zhang, +2 authors, Jing Yu.
J Cancer, 2021 Feb 04; 12(5). PMID: 33531977    Free PMC article.
Discovery of a new inhibitor targeting PD-L1 for cancer immunotherapy.
Fengling Wang, Wenling Ye, +9 authors, Xiaojun Yao.
Neoplasia, 2021 Feb 03; 23(3). PMID: 33529880    Free PMC article.
A gene expression-based immune signature for lung adenocarcinoma prognosis.
Lijuan Wang, Xizhi Luo, +3 authors, Feifei Xiao.
Cancer Immunol Immunother, 2020 May 07; 69(9). PMID: 32372138
Nanoscale metal-organic frameworks for x-ray activated in situ cancer vaccination.
Kaiyuan Ni, Guangxu Lan, +5 authors, Wenbin Lin.
Sci Adv, 2020 Oct 04; 6(40). PMID: 33008911    Free PMC article.
Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion.
Xun Wu, Yi-Shing Lisa Cheng, +5 authors, Fatemeh Momen-Heravi.
J Exp Clin Cancer Res, 2021 Feb 19; 40(1). PMID: 33596979    Free PMC article.
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy.
Tianyu Tang, Xing Huang, +3 authors, Tingbo Liang.
Signal Transduct Target Ther, 2021 Feb 21; 6(1). PMID: 33608497    Free PMC article.
Review.
Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment.
Zhiwu Tan, Mei Sum Chiu, +2 authors, Zhiwei Chen.
Mol Ther Oncolytics, 2021 Feb 23; 20. PMID: 33614918    Free PMC article.
Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1.
Jang-June Park, Emily P Thi, +20 authors, Chris B Moore.
Nat Commun, 2021 Feb 24; 12(1). PMID: 33619272    Free PMC article.
Immune subtyping for pancreatic cancer with implication in clinical outcomes and improving immunotherapy.
Jingkai Liu, Qiaofei Liu, +4 authors, Quan Liao.
Cancer Cell Int, 2021 Feb 28; 21(1). PMID: 33637086    Free PMC article.
HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy.
Marina R Tavares, Klára Hrabánková, +5 authors, Petr Chytil.
Pharmaceutics, 2021 Feb 03; 13(2). PMID: 33525658    Free PMC article.
Remission-Stage Ovarian Cancer Cell Vaccine with Cowpea Mosaic Virus Adjuvant Prevents Tumor Growth.
Courtney T Stump, Gregory Ho, +5 authors, Steven Fiering.
Cancers (Basel), 2021 Feb 11; 13(4). PMID: 33562450    Free PMC article.
Targeting Myeloid-Derived Suppressor Cells in Ovarian Cancer.
Seiji Mabuchi, Tomoyuki Sasano, Naoko Komura.
Cells, 2021 Feb 11; 10(2). PMID: 33562495    Free PMC article.
Review.
IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway.
Longhao Sun, Xuebin Zhang, +9 authors, Wei Zhang.
Cancer Lett, 2020 Dec 15; 500. PMID: 33309859    Free PMC article.
Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study.
Qinchuan Wang, Yuanqing Ye, +6 authors, Xifeng Wu.
Cancer Immunol Immunother, 2020 Sep 11; 70(3). PMID: 32909077    Free PMC article.
Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy.
Rangarirai Makuku, Neda Khalili, +2 authors, Nima Rezaei.
J Immunol Res, 2021 Mar 09; 2021. PMID: 33681388    Free PMC article.
Review.
Clinicopathological and prognostic significance of programmed death ligant-1 expression in gastric cancer: a meta-analysis.
Zhebing Qiu, Yinguo Du.
J Gastrointest Oncol, 2021 Mar 13; 12(1). PMID: 33708429    Free PMC article.
Immune Escape Mediated by Exosomal PD-L1 in Cancer.
Sean E Lawler, Michal O Nowicki, Franz L Ricklefs, E Antonio Chiocca.
Adv Biosyst, 2020 May 10; 4(12). PMID: 32383351    Free PMC article.
Review.
SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation.
Esther Redin, Irati Garmendia, +17 authors, Alfonso Calvo.
J Immunother Cancer, 2021 Mar 05; 9(3). PMID: 33658304    Free PMC article.
Anti-cancer effects of polyphenol-rich sugarcane extract.
Monica D Prakash, Lily Stojanovska, +6 authors, Vasso Apostolopoulos.
PLoS One, 2021 Mar 11; 16(3). PMID: 33690618    Free PMC article.
Novel Immune Stimulant Amplifies Direct Tumoricidal Effect of Cancer Ablation Therapies and Their Systemic Antitumor Immune Efficacy.
Mladen Korbelik, Tomas Hode, Samuel S K Lam, Wei R Chen.
Cells, 2021 Mar 07; 10(3). PMID: 33668932    Free PMC article.
Review.
Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint.
Peiyu Zhu, Jian Zhang, +3 authors, Huibin Zhang.
Mol Divers, 2021 Apr 01; 26(1). PMID: 33786726
The role of exosomes in tumour immunity under radiotherapy: eliciting abscopal effects?
Tianwen Yin, Huixian Xin, Jinming Yu, Feifei Teng.
Biomark Res, 2021 Apr 02; 9(1). PMID: 33789758    Free PMC article.
Review.
Promising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy-a preclinical study using a syngeneic breast cancer model.
Patrycja Guzik, Klaudia Siwowska, +4 authors, Cristina Müller.
Eur J Nucl Med Mol Imaging, 2020 Oct 21; 48(4). PMID: 33078260    Free PMC article.
TTN/OBSCN 'Double-Hit' predicts favourable prognosis, 'immune-hot' subtype and potentially better immunotherapeutic efficacy in colorectal cancer.
Zaoqu Liu, Libo Wang, +6 authors, Xinwei Han.
J Cell Mol Med, 2021 Feb 25; 25(7). PMID: 33624434    Free PMC article.
The safety and efficacy of neoadjuvant programmed death 1 inhibitor therapy with surgical resection in stage IIIA non-small cell lung cancer.
Jiangfeng Wang, Jianqiang Li, +2 authors, Youhua Jiang.
Ann Transl Med, 2021 Apr 15; 9(6). PMID: 33850883    Free PMC article.
Nephrotoxicity of Anti-Angiogenic Therapies.
Margaux Van Wynsberghe, Joanne Flejeo, +4 authors, Carole Henique.
Diagnostics (Basel), 2021 May 01; 11(4). PMID: 33916159    Free PMC article.
Review.
Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic Cancer.
Shivan Sivakumar, Enas Abu-Shah, +13 authors, Michael L Dustin.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33917832    Free PMC article.
Pembrolizumab-induced myasthenia gravis-like disorder, ocular myositis, and hepatitis: a case report.
Chia-Yi Tian, Yang-Hao Ou, Shih-Liang Chang, Chih-Ming Lin.
J Med Case Rep, 2021 May 01; 15(1). PMID: 33926558    Free PMC article.
Impact of PD-1 gene polymorphism and its interaction with tea drinking on susceptibility to tuberculosis.
Jing Wang, Mian Wang, +8 authors, Hengzhong Yi.
Epidemiol Infect, 2021 Jan 14; 149. PMID: 33436123    Free PMC article.
Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model.
Dina Stroopinsky, Jessica Liegel, +21 authors, David Avigan.
Haematologica, 2021 Feb 05; 106(5). PMID: 33538148    Free PMC article.
Intratumoral Foxp3+RORγt+ T cell infiltration determines poor prognosis and immunoevasive contexture in gastric cancer patients.
Yuchao Fei, Yifan Cao, +13 authors, Weijuan Zhang.
Cancer Immunol Immunother, 2021 May 13; 71(1). PMID: 33978826
PD-L1 Blockade During Allergen Sensitization Inhibits the Synthesis of Specific Antibodies and Decreases Mast Cell Activation in a Murine Model of Active Cutaneous Anaphylaxis.
Rafael Bonamichi-Santos, Marcelo Vivolo Aun, +2 authors, Pedro Giavina-Bianchi.
Front Immunol, 2021 May 11; 12. PMID: 33968057    Free PMC article.
Co-Occurring Alteration of NOTCH and DDR Pathways Serves as Novel Predictor to Efficacious Immunotherapy in NSCLC.
Zhimin Zhang, Yanyan Gu, +11 authors, Chuan Chen.
Front Oncol, 2021 May 11; 11. PMID: 33968765    Free PMC article.
Triple-negative breast cancer: A run-through of features, classification and current therapies.
Meghana Manjunath, Bibha Choudhary.
Oncol Lett, 2021 May 15; 22(1). PMID: 33986872    Free PMC article.
Review.
Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients.
Kaifeng Jin, Yifan Cao, +13 authors, Jiejie Xu.
Oncoimmunology, 2021 May 18; 10(1). PMID: 33996266    Free PMC article.
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Julia Koerner, Dennis Horvath, +5 authors, Marcus Groettrup.
Nat Commun, 2021 May 20; 12(1). PMID: 34006895    Free PMC article.
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.
David A Braun, Kelly Street, +32 authors, Catherine J Wu.
Cancer Cell, 2021 Mar 13; 39(5). PMID: 33711273    Free PMC article.
Myeloid-Derived Suppressor Cells as Therapeutic Targets in Uterine Cervical and Endometrial Cancers.
Seiji Mabuchi, Tomoyuki Sasano.
Cells, 2021 May 06; 10(5). PMID: 33946532    Free PMC article.
Review.
A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy.
Yuanyuan Wang, Tingxuan Gu, +9 authors, Mee-Hyun Lee.
Front Immunol, 2021 Jun 01; 12. PMID: 34054817    Free PMC article.
Immunotherapy and Gene Therapy for Oncoviruses Infections: A Review.
Nathália Alves Araújo de Almeida, Camilla Rodrigues de Almeida Ribeiro, Jéssica Vasques Raposo, Vanessa Salete de Paula.
Viruses, 2021 Jun 03; 13(5). PMID: 34063186    Free PMC article.
Review.
Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer.
Alyssa Vito, Stephanie Rathmann, +3 authors, John Valliant.
Int J Mol Sci, 2021 Jun 03; 22(9). PMID: 34063642    Free PMC article.
Association of RYR2 Mutation With Tumor Mutation Burden, Prognosis, and Antitumor Immunity in Patients With Esophageal Adenocarcinoma.
Zaoqu Liu, Long Liu, +6 authors, Xinwei Han.
Front Genet, 2021 Jun 04; 12. PMID: 34079583    Free PMC article.
A brand new era of cancer immunotherapy: breakthroughs and challenges.
Ri-Lan Bai, Nai-Fei Chen, Ling-Yu Li, Jiu-Wei Cui.
Chin Med J (Engl), 2021 May 28; 134(11). PMID: 34039862    Free PMC article.
Review.

;. PMID: 34098941
Clinical Perspectives to Overcome Acquired Resistance to Anti-Programmed Death-1 and Anti-Programmed Death Ligand-1 Therapy in Non-Small Cell Lung Cancer.
Yong Jun Lee, Jii Bum Lee, Sang-Jun Ha, Hye Ryun Kim.
Mol Cells, 2021 May 19; 44(5). PMID: 34001680    Free PMC article.
Review.
Development and validation of an individualized immune prognostic model in stage I-III lung squamous cell carcinoma.
Qi-Fan Yang, Di Wu, +5 authors, Li Liu.
Sci Rep, 2021 Jun 18; 11(1). PMID: 34135424    Free PMC article.
Traceable metallic antigen release for enhanced cancer immunotherapy.
Fangfang Lv, Yan Jin, +7 authors, Huifang Liu.
J Nanopart Res, 2021 Jun 22; 23(6). PMID: 34149308    Free PMC article.
Inorganic Nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy.
Jie Wang, Lan Fang, +5 authors, Dawei Deng.
Nanomicro Lett, 2019 Sep 09; 11(1). PMID: 34138044    Free PMC article.
Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis.
Mayu Sun, Pengfei Gu, +7 authors, Hui Wang.
J Immunother Cancer, 2021 Jun 13; 9(6). PMID: 34117115    Free PMC article.
Combined OX40 Agonist and PD-1 Inhibitor Immunotherapy Improves the Efficacy of Vascular Targeted Photodynamic Therapy in a Urothelial Tumor Model.
Ricardo G Alvim, Petrina Georgala, +14 authors, Jonathan A Coleman.
Molecules, 2021 Jul 03; 26(12). PMID: 34205347    Free PMC article.
Multidiscipline Immunotherapy-Based Rational Combinations for Robust and Durable Efficacy in Brain Metastases from Renal Cell Carcinoma.
Hye-Won Lee.
Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34208157    Free PMC article.
Review.
The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells.
Zongcai Liu, Fen Ning, +9 authors, Li Liu.
Cancer Commun (Lond), 2021 Jul 09; 41(1). PMID: 34236149    Free PMC article.
Establishment and experimental validation of an immune miRNA signature for assessing prognosis and immune landscape of patients with colorectal cancer.
Zaoqu Liu, Taoyuan Lu, +7 authors, Xinwei Han.
J Cell Mol Med, 2021 Jun 09; 25(14). PMID: 34101338    Free PMC article.
Ubiquitin ligases in cancer: Functions and clinical potentials.
Shanshan Duan, Michele Pagano.
Cell Chem Biol, 2021 May 12; 28(7). PMID: 33974914    Free PMC article.
Review.
Comparisons of Underlying Mechanisms, Clinical Efficacy and Safety Between Anti-PD-1 and Anti-PD-L1 Immunotherapy: The State-of-the-Art Review and Future Perspectives.
Yating Zhao, Liu Liu, Liang Weng.
Front Pharmacol, 2021 Jul 27; 12. PMID: 34305619    Free PMC article.
Review.
Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories.
Shinichi Mizuno, Rui Yamaguchi, +16 authors, Seiya Imoto.
Sci Rep, 2021 Aug 05; 11(1). PMID: 34344966    Free PMC article.
Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies.
Gihoon You, Jonghwa Won, +4 authors, Seung-Woo Lee.
Vaccines (Basel), 2021 Aug 07; 9(7). PMID: 34358141    Free PMC article.
Review.
Identification of active small-molecule modulators targeting the novel immune checkpoint VISTA.
Ting-Ting Li, Jing-Wei Jiang, +5 authors, Jun Liu.
BMC Immunol, 2021 Aug 13; 22(1). PMID: 34380434    Free PMC article.
Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.
Damian Muszak, Ewa Surmiak, +11 authors, Tad A Holak.
J Med Chem, 2021 Jul 28; 64(15). PMID: 34313116    Free PMC article.
Nuclear cardiology in the context of multimodality imaging to detect cardiac toxicity from cancer therapeutics: Established and emerging methods.
Aaron Soufer, Chi Liu, Mariana L Henry, Lauren A Baldassarre.
J Nucl Cardiol, 2019 Mar 15; 27(4). PMID: 30868378
Review.
Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance.
Bashir Lawal, Sung-Hui Tseng, +6 authors, Alexander T H Wu.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439277    Free PMC article.
Identification and Characterization of Alcohol-related Hepatocellular Carcinoma Prognostic Subtypes based on an Integrative N6-methyladenosine methylation Model.
Yue Zhang, Fanhong Zeng, +5 authors, Yi Gao.
Int J Biol Sci, 2021 Sep 14; 17(13). PMID: 34512165    Free PMC article.
Combination immunotherapy of chlorogenic acid liposomes modified with sialic acid and PD-1 blockers effectively enhances the anti-tumor immune response and therapeutic effects.
Xixi Li, Shunyao Zhu, +5 authors, Ting Zhang.
Drug Deliv, 2021 Sep 14; 28(1). PMID: 34515617    Free PMC article.
Magnetic systems for cancer immunotherapy.
Nicole B Day, William C Wixson, C Wyatt Shields.
Acta Pharm Sin B, 2021 Sep 16; 11(8). PMID: 34522583    Free PMC article.
Review.
The best regimens for chemo-naïve incurable non-squamous non-small cell lung cancer with a programmed death-ligand 1, tumor proportion score 1-49%: a network meta-analysis.
Nobuhiko Fukuda, Nobuyuki Horita, +8 authors, Takeshi Kaneko.
Transl Lung Cancer Res, 2021 Sep 30; 10(8). PMID: 34584856    Free PMC article.
Combining Photodynamic Therapy with Immunostimulatory Nanoparticles Elicits Effective Anti-Tumor Immune Responses in Preclinical Murine Models.
Ruben Victor Huis In 't Veld, Candido G Da Silva, +2 authors, Ferry Ossendorp.
Pharmaceutics, 2021 Sep 29; 13(9). PMID: 34575546    Free PMC article.
Overcoming Chemoimmunotherapy-Induced Immunosuppression by Assemblable and Depot Forming Immune Modulating Nanosuspension.
Seung Mo Jin, Sang Nam Lee, +7 authors, Yong Taik Lim.
Adv Sci (Weinh), 2021 Aug 08; 8(19). PMID: 34363349    Free PMC article.
Liquid Biopsy Biomarkers for Immunotherapy in Non-Small Cell Lung Carcinoma: Lessons Learned and the Road Ahead.
Jesus Hita-Millan, Angel Carracedo, Ceres Fernandez-Rozadilla.
J Pers Med, 2021 Oct 24; 11(10). PMID: 34683113    Free PMC article.
Review.
Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer.
Cristina Saiz-Ladera, Mariona Baliu-Piqué, +10 authors, Alberto Ocana.
Front Oncol, 2021 Oct 26; 11. PMID: 34692491    Free PMC article.
Emerging concepts in PD-1 checkpoint biology.
Kristen E Pauken, James A Torchia, +2 authors, Gordon J Freeman.
Semin Immunol, 2021 May 20; 52. PMID: 34006473    Free PMC article.
Review.
KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.
Bo Yu, Fei Luo, +7 authors, Haizhong Feng.
Adv Sci (Weinh), 2021 Aug 16; 8(20). PMID: 34392614    Free PMC article.
Identification of Novel Modalities Through Bibliometric Analysis for Timely Development of Regulatory Guidance: A Case Study of T Cell Immunity.
Ai Fukaya-Shiba, Kouhei Otsuka, +2 authors, Rika Wakao.
Front Med (Lausanne), 2021 Oct 29; 8. PMID: 34708061    Free PMC article.
A nomogram-based immunoprofile predicts clinical outcomes for stage II and III human colorectal cancer.
Lingxiong Wang, Nijia Chang, +7 authors, Shunchang Jiao.
Mol Clin Oncol, 2021 Oct 30; 15(6). PMID: 34712487    Free PMC article.
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Kazuhiro Koikawa, Shin Kibe, +24 authors, Kun Ping Lu.
Cell, 2021 Aug 14; 184(18). PMID: 34388391    Free PMC article.
Exosome CTLA-4 Regulates PTEN/CD44 Signal Pathway in Spleen Deficiency Internal Environment to Promote Invasion and Metastasis of Hepatocellular Carcinoma.
Yongdan Wang, Pan Li, +7 authors, Ling Yu.
Front Pharmacol, 2021 Nov 09; 12. PMID: 34744733    Free PMC article.
Computational Recognition and Clinical Verification of TGF-β-Derived miRNA Signature With Potential Implications in Prognosis and Immunotherapy of Intrahepatic Cholangiocarcinoma.
Zaoqu Liu, Siyuan Weng, +8 authors, Xinwei Han.
Front Oncol, 2021 Nov 12; 11. PMID: 34760703    Free PMC article.
CMTM6, a potential immunotherapy target.
Jie Liang, Shaohua Li, +9 authors, Bei Zhang.
J Cancer Res Clin Oncol, 2021 Nov 17; 148(1). PMID: 34783871
Review.
Neutrophils Extracellular Traps Inhibition Improves PD-1 Blockade Immunotherapy in Colorectal Cancer.
Hongji Zhang, Yu Wang, +12 authors, Allan Tsung.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771497    Free PMC article.
Predicting a Kind of Unusual Multiple-States Dimerization-Modes Transformation in Protein PD-L1 System by Computational Investigation and a Generalized Rate Theory.
Zhong-Xing Zhou, Hong-Xing Zhang, Qing-Chuan Zheng.
Front Chem, 2021 Dec 04; 9. PMID: 34858950    Free PMC article.
Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy.
Wenqing Li, Xinfu Zhang, +12 authors, Yizhou Dong.
Nat Commun, 2021 Dec 16; 12(1). PMID: 34907171    Free PMC article.
Chemokines modulate glycan binding and the immunoregulatory activity of galectins.
Lucía Sanjurjo, Iris A Schulkens, +10 authors, Victor L J L Thijssen.
Commun Biol, 2021 Dec 22; 4(1). PMID: 34931005    Free PMC article.
Combination of CTLA-4 blockade with MUC1 mRNA nanovaccine induces enhanced anti-tumor CTL activity by modulating tumor microenvironment of triple negative breast cancer.
Xuan Lin, Hedan Chen, +9 authors, Lina Liu.
Transl Oncol, 2021 Dec 08; 15(1). PMID: 34875483    Free PMC article.
MAPK Activated Protein Kinase 3 Is a Prognostic-Related Biomarker and Associated With Immune Infiltrates in Glioma.
Jing Ren, Jinmin Sun, +3 authors, Haowei Cao.
Front Oncol, 2021 Dec 24; 11. PMID: 34938665    Free PMC article.
Integrative analysis from multi-center studies identities a consensus machine learning-derived lncRNA signature for stage II/III colorectal cancer.
Zaoqu Liu, ChunGuang Guo, +7 authors, Xinwei Han.
EBioMedicine, 2021 Dec 19; 75. PMID: 34922323    Free PMC article.
Differentially Expressed Genes in Clear Cell Renal Cell Carcinoma as a Potential Marker for Prognostic and Immune Signatures.
Ying Tong, Yiwen Yu, +5 authors, Lin Guo.
Front Oncol, 2022 Jan 04; 11. PMID: 34976818    Free PMC article.
Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses.
Xia Bu, Vikram R Juneja, +12 authors, Gordon J Freeman.
Cancer Immunol Res, 2021 Oct 13; 9(12). PMID: 34635486    Free PMC article.
Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer.
Ward Celus, Ana I Oliveira, +15 authors, Massimiliano Mazzone.
Cancer Immunol Res, 2021 Nov 25; 10(1). PMID: 34815265    Free PMC article.
pH Low Insertion Peptide-Modified Programmed Cell Death-Ligand 1 Potently Suppresses T-Cell Activation Under Acidic Condition.
Ying Sun, Linhan Hu, +11 authors, Guojiang Chen.
Front Immunol, 2022 Jan 11; 12. PMID: 35003115    Free PMC article.
Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells.
Yanyun Du, Qianwen Peng, +18 authors, Chenhui Wang.
Nat Commun, 2022 Jan 13; 13(1). PMID: 35017553    Free PMC article.
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Bryan K Chan, Eileen Seward, +24 authors, Timothy P Heffron.
ACS Med Chem Lett, 2022 Jan 22; 13(1). PMID: 35059127    Free PMC article.
Immunological Classification of Pancreatic Carcinomas to Identify Immune Index and Provide a Strategy for Patient Stratification.
Yi Chen, Didi Chen, +4 authors, Huafang Su.
Front Immunol, 2022 Feb 04; 12. PMID: 35111149    Free PMC article.
Prospects of Immunotherapy for Triple-Negative Breast Cancer.
Dan Qiu, Guijuan Zhang, +9 authors, Min Ma.
Front Oncol, 2022 Feb 04; 11. PMID: 35111680    Free PMC article.
Review.
Effectiveness and safety of combined therapy versus monotherapy based on immune checkpoint inhibitors and/or targeted drugs as salvage treatment for advanced urothelial carcinoma: a systematic review and meta-analysis.
Lichao Wei, Liang Gao, Zili Hu, Chuan Liu.
Transl Cancer Res, 2022 Feb 05; 10(5). PMID: 35116530    Free PMC article.
Proteomics score: a potential biomarker for the prediction of prognosis in non-small cell lung cancer.
Jie Peng, Jing Zhang, Dan Zou, Wuxing Gong.
Transl Cancer Res, 2019 Sep 01; 8(5). PMID: 35116940    Free PMC article.
A Darwinian perspective on tumor immune evasion.
Julieann Puleo, Kornelia Polyak.
Biochim Biophys Acta Rev Cancer, 2021 Dec 22; 1877(1). PMID: 34933050    Free PMC article.
Review.
Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer.
Zaoqu Liu, Long Liu, +8 authors, Xinwei Han.
Nat Commun, 2022 Feb 12; 13(1). PMID: 35145098    Free PMC article.
First-Line Treatment of Advanced Non-Small-Cell Lung Cancer with Immune-Checkpoint Inhibitors: New Combinations and Long-Term Data.
Maxime Bossageon, Aurélie Swalduz, Christos Chouaïd, Olivier Bylicki.
BioDrugs, 2022 Feb 12; 36(2). PMID: 35147894
Review.
A Review of Emerging Biomarkers for Immune Checkpoint Inhibitors in Tumors of the Gastrointestinal Tract.
Xuqiang Liao, Gao Li, Renzhong Cai, Ru Chen.
Med Sci Monit, 2022 Feb 06; 28. PMID: 35121724    Free PMC article.
Review.
Nevi, dysplastic nevi, and melanoma: Molecular and immune mechanisms involving the progression.
Wei-Wen Sung, Chung-Hsing Chang.
Tzu Chi Med J, 2022 Mar 03; 34(1). PMID: 35233349    Free PMC article.
Review.
Nocardia rubra cell-wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells.
Siyang Zhang, Han Wang, +4 authors, Min Wang.
Cancer Med, 2022 Jan 08; 11(5). PMID: 34994088    Free PMC article.
Cardiotoxicity risk factors with immune checkpoint inhibitors.
Zachary L Brumberger, Mary E Branch, +3 authors, Sujethra Vasu.
Cardiooncology, 2022 Mar 13; 8(1). PMID: 35277208    Free PMC article.
Polymeric Systems for Cancer Immunotherapy: A Review.
Thai Minh Duy Le, A-Rum Yoon, Thavasyappan Thambi, Chae-Ok Yun.
Front Immunol, 2022 Mar 12; 13. PMID: 35273607    Free PMC article.
Review.
Cilengitide, an αvβ3-integrin inhibitor, enhances the efficacy of anti-programmed cell death-1 therapy in a murine melanoma model.
Xin Pan, Minxiao Yi, +4 authors, Xianglin Yuan.
Bioengineered, 2022 Feb 11; 13(2). PMID: 35142593    Free PMC article.
Fruquintinib Enhances the Antitumor Immune Responses of Anti-Programmed Death Receptor-1 in Colorectal Cancer.
Qingli Li, Xiaojiao Cheng, +6 authors, Shuiping Tu.
Front Oncol, 2022 Apr 05; 12. PMID: 35371995    Free PMC article.
Anti-CTLA-4 and anti-PD-1 immunotherapies repress tumor progression in preclinical breast and colon model with independent regulatory T cells response.
Tristan Rupp, Laurie Genest, +4 authors, Vincent Castagné.
Transl Oncol, 2022 Mar 28; 20. PMID: 35339889    Free PMC article.
Adaptive antitumor immune response stimulated by bio-nanoparticle based vaccine and checkpoint blockade.
Xuewei Bai, Yanmei Zhou, +11 authors, Jack R Wands.
J Exp Clin Cancer Res, 2022 Apr 09; 41(1). PMID: 35392977    Free PMC article.
T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.
Karin H Simons, Alwin de Jong, +3 authors, Paul H A Quax.
Nat Rev Cardiol, 2019 Feb 17; 16(6). PMID: 30770894
Review.
Current trends of targeted therapy for oral squamous cell carcinoma.
Hongjiao Li, Yao Zhang, Mengmeng Xu, Deqin Yang.
J Cancer Res Clin Oncol, 2022 May 03;. PMID: 35501496
Review.
Insights into breast cancer phenotying through molecular omics approaches and therapy response.
Jose E Belizario, Angela F Loggulo.
Cancer Drug Resist, 2019 Sep 19; 2(3). PMID: 35582587    Free PMC article.
Review.
The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma.
Shi-Yi Wu, Zhao-Yu Xie, +5 authors, Hong-Tao Sun.
BMC Immunol, 2022 Jun 07; 23(1). PMID: 35659256