Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

Joseph A Sparano ¹, Robert J Gray , Della F Makower , Kathleen I Pritchard , Kathy S Albain , Daniel F Hayes , Charles E Geyer , Elizabeth C Dees , Edith A Perez , John A Olson , JoAnne Zujewski , Tracy Lively , Sunil S Badve , Thomas J Saphner , Lynne I Wagner , Timothy J Whelan , Matthew J Ellis , Soonmyung Paik , William C Wood , Peter Ravdin , Maccon M Keane , Henry L Gomez Moreno , Pavan S Reddy , Timothy F Goggins , Ingrid A Mayer , Adam M Brufsky , Deborah L Toppmeyer , Virginia G Kaklamani , James N Atkins , Jeffrey L Berenberg , George W Sledge

Affiliations

¹ From the Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (J.A.S., D.F.M.); Dana-Farber Cancer Institute, Boston (R.J.G.); Sunnybrook Research Institute, Toronto (K.I.P.) and Juravinski Cancer Center, Hamilton, ON (T.J.W.) - both in Canada; Loyola University Medical Center, Maywood (K.S.A.), and Northwestern University, Chicago (L.I.W., V.G.K.) - both in Illinois; University of Michigan, Ann Arbor (D.F.H.); Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond (C.E.G.); University of North Carolina, Chapel Hill (E.C.D.), Duke University Medical Center, Durham (J.A.O.), Wake Forest University Health Service, Winston-Salem (L.I.W.), and Southeast Clinical Oncology Research Consortium, Goldsboro (J.N.A.) - all in North Carolina; Mayo Clinic, Jacksonville, FL (E.A.P.); University of Maryland School of Medicine, Baltimore (J.A.O.), and National Institutes of Health, Bethesda (J.Z., T.L.) - both in Maryland; Indiana University School of Medicine (S.S.B.) and Indiana University Hospital (G.W.S.) - both in Indianapolis; Vince Lombardi Cancer Clinic, Two Rivers (T.J.S.), and Fox Valley Hematology and Oncology, Appleton (T.F.G.) - both in Wisconsin; Baylor College of Medicine, Houston (M.J.E.), and University of Texas, San Antonio (P.R.) - both in Texas; Washington University, St. Louis (M.J.E.); Allegheny General Hospital (S.P.) and University of Pittsburgh (A.M.B.) - both in Pittsburgh; the Department of Medical Oncology and Breast Center, Yonsei University College of Medicine, Seoul, South Korea (S.P.); Emory University, Atlanta (W.C.W.); Irish Clinical Oncology Research Group, Dublin (M.M.K.); Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru (H.L.G.M.); Cancer Center of Kansas, Wichita (P.S.R.); Vanderbilt University, Nashville (I.A.M.); Rutgers Cancer Institute of New Jersey, New Brunswick (D.L.T.); University of Hawaii Cancer Center, Honolulu (J.L.B.); and Stanford University, Stanford, CA (G.W.S.)

PMID: 26412349
37 References
322 citations

Abstract

Background: Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker.

Methods: We performed a prospective trial involving women with hormone-receptor-positive, human epidermal growth factor receptor type 2 (HER2)-negative, axillary node-negative breast cancer with tumors of 1.1 to 5.0 cm in the greatest dimension (or 0.6 to 1.0 cm in the greatest dimension and intermediate or high tumor grade) who met established guidelines for the consideration of adjuvant chemotherapy on the basis of clinicopathologic features. A reverse-transcriptase-polymerase-chain-reaction assay of 21 genes was performed on the paraffin-embedded tumor tissue, and the results were used to calculate a score indicating the risk of breast-cancer recurrence; patients were assigned to receive endocrine therapy without chemotherapy if they had a recurrence score of 0 to 10, indicating a very low risk of recurrence (on a scale of 0 to 100, with higher scores indicating a greater risk of recurrence).

Results: Of the 10,253 eligible women enrolled, 1626 women (15.9%) who had a recurrence score of 0 to 10 were assigned to receive endocrine therapy alone without chemotherapy. At 5 years, in this patient population, the rate of invasive disease-free survival was 93.8% (95% confidence interval [CI], 92.4 to 94.9), the rate of freedom from recurrence of breast cancer at a distant site was 99.3% (95% CI, 98.7 to 99.6), the rate of freedom from recurrence of breast cancer at a distant or local-regional site was 98.7% (95% CI, 97.9 to 99.2), and the rate of overall survival was 98.0% (95% CI, 97.1 to 98.6).

Conclusions: Among patients with hormone-receptor-positive, HER2-negative, axillary node-negative breast cancer who met established guidelines for the recommendation of adjuvant chemotherapy on the basis of clinicopathologic features, those with tumors that had a favorable gene-expression profile had very low rates of recurrence at 5 years with endocrine therapy alone. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00310180.).

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Outcomes in patients with early-stage breast cancer who underwent a 21-gene expression assay. Carlos H Barcenas, Akshara Raghavendra, +10 authors, Debu Tripathy. less Cancer, 2017 Feb 16; 123(13). PMID: 28199747 Free PMC article.
Epidemiology and survival outcome of breast cancer in a nationwide study. Fu-Chao Liu, Huan-Tang Lin, +3 authors, Huang-Ping Yu. less Oncotarget, 2017 Feb 16; 8(10). PMID: 28199975 Free PMC article.
Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays. David M Hyams, Eric Schuur, +7 authors, Aníbal Nuñez De Pierro. less J Surg Oncol, 2017 Feb 18; 115(6). PMID: 28211064 Free PMC article. Review.
Oncotype DX breast cancer recurrence score can be predicted with a novel nomogram using clinicopathologic data. Amila Orucevic, John L Bell, Alison P McNabb, Robert E Heidel. Breast Cancer Res Treat, 2017 Mar 01; 163(1). PMID: 28243897 Free PMC article.
Correlations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkey. Vahit Özmen, Ajlan Atasoy, +9 authors, Pınar Saip. less J Breast Health, 2016 Jan 01; 12(3). PMID: 28331745 Free PMC article.
21-Gene recurrence score testing among Medicare beneficiaries with breast cancer in 2010-2013. Julie A Lynch, Brygida Berse, Nicole Coomer, John Kautter. Genet Med, 2017 Mar 24; 19(10). PMID: 28333918
Distribution patterns of 21-gene recurrence score in 980 Chinese estrogen receptor-positive, HER2-negative early breast cancer patients. Jiayi Wu, Yan Fang, +11 authors, Kunwei Shen. less Oncotarget, 2017 Apr 14; 8(24). PMID: 28404972 Free PMC article.
Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research. Kathryn A Phillips, Patricia A Deverka, +6 authors, Michael P Douglas. less Genet Med, 2017 Apr 14; 19(10). PMID: 28406488 Free PMC article. Review.
Using the 21-gene assay from core needle biopsies to choose neoadjuvant therapy for breast cancer: A multicenter trial. Harry D Bear, Wen Wan, +8 authors, Amy P Sing. less J Surg Oncol, 2017 Apr 14; 115(8). PMID: 28407247 Free PMC article.
Adjuvant treatment recommendations for patients with ER-positive/HER2-negative early breast cancer by Swiss tumor boards using the 21-gene recurrence score (SAKK 26/10). Bernhard C Pestalozzi, Christoph Tausch, +17 authors, Swiss Group for Clinical Cancer Research (SAKK). less BMC Cancer, 2017 Apr 15; 17(1). PMID: 28407750 Free PMC article.
Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer. Tristan Gallenne, Kenneth N Ross, +6 authors, Daniel S Peeper. less Oncotarget, 2017 Apr 16; 8(13). PMID: 28411283 Free PMC article.
Immunohistochemical Ki67 after short-term hormone therapy identifies low-risk breast cancers as reliably as genomic markers. Takayuki Iwamoto, Toyomasa Katagiri, +12 authors, Junji Matsuoka. less Oncotarget, 2017 Apr 17; 8(16). PMID: 28412725 Free PMC article.
Comparison of standardized uptake value of 18F-FDG-PET-CT with 21-gene recurrence score in estrogen receptor-positive, HER2-negative breast cancer. Sung Gwe Ahn, Jae-Hoon Lee, +8 authors, Seung Il Kim. less PLoS One, 2017 Apr 19; 12(4). PMID: 28419166 Free PMC article.
"Targeted" Chemotherapy for Esophageal Cancer. Joe Abdo, Devendra K Agrawal, Sumeet K Mittal. Front Oncol, 2017 Apr 20; 7. PMID: 28421164 Free PMC article.
Limitations of Personalized Medicine and Gene Assays for Breast Cancer. David Tiberi, Laura Masucci, +5 authors, Philip Wong. less Cureus, 2017 Apr 22; 9(3). PMID: 28428927 Free PMC article.
Current Update of Patient-Derived Xenograft Model for Translational Breast Cancer Research. Tsutomu Kawaguchi, Barbara A Foster, Jessica Young, Kazuaki Takabe. J Mammary Gland Biol Neoplasia, 2017 Apr 30; 22(2). PMID: 28451789 Free PMC article. Review.
Inferring gene regulatory relationships with a high-dimensional robust approach. Yangguang Zang, Qing Zhao, +3 authors, Shuangge Ma. less Genet Epidemiol, 2017 May 04; 41(5). PMID: 28464328 Free PMC article.
An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®. Zsuzsanna Varga, Annette Lebeau, +18 authors, Giuseppe Viale. less Breast Cancer Res, 2017 May 12; 19(1). PMID: 28490348 Free PMC article.
Uptake of a 21-gene expression assay in breast cancer practice: views of academic and community-based oncologists. M A O'Brien, S Dhesy-Thind, +3 authors, E Grunfeld. less Curr Oncol, 2017 May 12; 24(2). PMID: 28490937 Free PMC article.
Neoadjuvant Trials in ER+ Breast Cancer: A Tool for Acceleration of Drug Development and Discovery. Angel L Guerrero-Zotano, Carlos L Arteaga. Cancer Discov, 2017 May 13; 7(6). PMID: 28495849 Free PMC article. Review.
Clinical utility of gene-expression signatures in early stage breast cancer. Maryann Kwa, Andreas Makris, Francisco J Esteva. Nat Rev Clin Oncol, 2017 Jun 01; 14(10). PMID: 28561071 Highly Cited. Review.
Unmet Needs in Clinical Research in Breast Cancer: Where Do We Need to Go? Ann H Partridge, Lisa A Carey. Clin Cancer Res, 2017 Jun 03; 23(11). PMID: 28572255 Free PMC article.
The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis. Gulisa Turashvili, Edi Brogi, +4 authors, Hannah Y Wen. less Breast Cancer Res Treat, 2017 Jun 04; 165(1). PMID: 28577081 Free PMC article.
RAS pathway biomarkers for breast cancer prognosis. Lauren L Siewertsz van Reesema, Michael P Lee, +5 authors, Amy H Tang. less Clin Lab Int, 2017 Jun 06; 40. PMID: 28579913 Free PMC article.
The role of skin ulceration in breast carcinoma staging and outcome. Thaer Khoury, Carmelo Gaudioso, +8 authors, Rebecca Jacobson. less Breast J, 2017 Jun 10; 24(1). PMID: 28597587 Free PMC article.
Clinical use of the Oncotype DX genomic test to guide treatment decisions for patients with invasive breast cancer. Terri P McVeigh, Michael J Kerin. Breast Cancer (Dove Med Press), 2017 Jun 16; 9. PMID: 28615971 Free PMC article. Review.
Neoadjuvant Therapy for Breast Cancer: Established Concepts and Emerging Strategies. Tessa G Steenbruggen, Mette S van Ramshorst, +3 authors, Gabe S Sonke. less Drugs, 2017 Jun 16; 77(12). PMID: 28616845 Review.
Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm. Daniel J McGrail, Curtis Chun-Jen Lin, +11 authors, Shiaw-Yih Lin. less NPJ Syst Biol Appl, 2017 Jun 27; 3. PMID: 28649435 Free PMC article.
Prognostic and functional role of subtype-specific tumor-stroma interaction in breast cancer. Giuseppe Merlino, Patrizia Miodini, +3 authors, Maria Grazia Daidone. less Mol Oncol, 2017 Jul 04; 11(10). PMID: 28672102 Free PMC article.
Oncologists' influence on receipt of adjuvant chemotherapy: does it matter whom you see for treatment of curable breast cancer? Steven J Katz, Sarah T Hawley, +4 authors, Allison W Kurian. less Breast Cancer Res Treat, 2017 Jul 10; 165(3). PMID: 28689364 Free PMC article.
21-Gene recurrence score and locoregional recurrence in lymph node-negative, estrogen receptor-positive breast cancer. Gulisa Turashvili, Joanne F Chou, +5 authors, Hannah Y Wen. less Breast Cancer Res Treat, 2017 Jul 14; 166(1). PMID: 28702894 Free PMC article.
Comparison of Oncotype DX® Recurrence Score® with other risk assessment tools including the Nottingham Prognostic Index in the identification of patients with low-risk invasive breast cancer. Maura Bríd Cotter, Alex Dakin, +5 authors, Cecily M Quinn. less Virchows Arch, 2017 Jul 15; 471(3). PMID: 28707056
Heterogeneous Enhancement Patterns of Tumor-adjacent Parenchyma at MR Imaging Are Associated with Dysregulated Signaling Pathways and Poor Survival in Breast Cancer. Jia Wu, Bailiang Li, +6 authors, Ruijiang Li. less Radiology, 2017 Jul 15; 285(2). PMID: 28708462 Free PMC article.
Learning from big data: are we undertreating older women with high-risk breast cancer? Joseph A Sparano, Hyman Muss. NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721380 Free PMC article.
Breast-cancer-specific mortality in patients treated based on the 21-gene assay: a SEER population-based study. Valentina I Petkov, Dave P Miller, +21 authors, Steven Shak. less NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721379 Free PMC article. Highly Cited.
Bioscore: A Staging System for Breast Cancer Patients that Reflects the Prognostic Significance of Underlying Tumor Biology. Elizabeth A Mittendorf, Mariana Chavez-MacGregor, +5 authors, Kelly K Hunt. less Ann Surg Oncol, 2017 Jul 21; 24(12). PMID: 28726077 Free PMC article.
Initial Treatment of Patients with Primary Breast Cancer: Evidence, Controversies, Consensus: Spectrum of Opinion of German Specialists at the 15th International St. Gallen Breast Cancer Conference (Vienna 2017). Michael Untch, Jens Huober, +18 authors, Cornelia Liedtke. less Geburtshilfe Frauenheilkd, 2017 Aug 05; 77(6). PMID: 28769126 Free PMC article.
CKAP2 (cytoskeleton-associated protein2) is a new prognostic marker in HER2-negative luminal type breast cancer. Sung Hoon Sim, Chang-Dae Bae, +16 authors, Jungsil Ro. less PLoS One, 2017 Aug 05; 12(8). PMID: 28771517 Free PMC article.
How to Achieve Optimal Care in Early Breast Cancer with 'Less' or 'More' Treatment. Giuseppe Curigliano. Breast Care (Basel), 2017 Aug 09; 12(3). PMID: 28785179 Free PMC article.
Extended Adjuvant Endocrine Therapy in Hormone Receptor-Positive Early Breast Cancer. Dara B Bracken-Clarke, Mairi W Lucas, Michaela J Higgins. Breast Care (Basel), 2017 Aug 09; 12(3). PMID: 28785180 Free PMC article. Review.
What Factors Influence Women's Perceptions of their Systemic Recurrence Risk after Breast Cancer Treatment? Kamaria L Lee, Nancy K Janz, +6 authors, Sarah T Hawley. less Med Decis Making, 2017 Aug 18; 38(1). PMID: 28814131 Free PMC article.
Adjusting for covariates in evaluating markers for selecting treatment, with application to guiding chemotherapy for treating estrogen-receptor-positive, node-positive breast cancer. Holly Janes, Marshall D Brown, +2 authors, Michael R Crager, Dave P Miller, William E Barlow. less Contemp Clin Trials, 2017 Aug 19; 63. PMID: 28818434 Free PMC article.
De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017. G Curigliano, H J Burstein, +52 authors, B Xu. less Ann Oncol, 2017 Aug 26; 28(8). PMID: 28838210 Free PMC article. Highly Cited.
Implementation and Feasibility of Electronic Patient-Reported Outcome (ePRO) Data Entry in the PRAEGNANT Real-Time Advanced and Metastatic Breast Cancer Registry. Markus Wallwiener, Felix Heindl, +28 authors, Paul Gass. less Geburtshilfe Frauenheilkd, 2017 Aug 29; 77(8). PMID: 28845051 Free PMC article.
Multiplexed analysis of fixed tissue RNA using Ligation in situ Hybridization. Joel J Credle, Christopher Y Itoh, +11 authors, H Benjamin Larman. less Nucleic Acids Res, 2017 Sep 01; 45(14). PMID: 28854731 Free PMC article.
Validation of the 18-gene classifier as a prognostic biomarker of distant metastasis in breast cancer. Skye Hung-Chun Cheng, Tzu-Ting Huang, +6 authors, Ben-Long Yu. less PLoS One, 2017 Sep 09; 12(9). PMID: 28886126 Free PMC article.
The genetic landscape of programmed death ligand-1 (PD-L1) alterations in head and neck cancer. Thomas E Heineman, Adam Widman, Edward C Kuan, Maie St John. Laryngoscope Investig Otolaryngol, 2017 Sep 13; 2(3). PMID: 28894827 Free PMC article.
Clinical outcomes in ER+ HER2 -node-positive breast cancer patients who were treated according to the Recurrence Score results: evidence from a large prospectively designed registry. Salomon M Stemmer, Mariana Steiner, +13 authors, Noa Ben-Baruch. less NPJ Breast Cancer, 2017 Sep 14; 3. PMID: 28900632 Free PMC article.
Clinical outcomes in patients with node-negative breast cancer treated based on the recurrence score results: evidence from a large prospectively designed registry. Salomon M Stemmer, Mariana Steiner, +21 authors, Nicky Liebermann. less NPJ Breast Cancer, 2017 Sep 14; 3. PMID: 28900633 Free PMC article.
Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer. Chiranjeevi Padala, Mohini Aiyengar Tupurani, +13 authors, Surekha Rani Hanumanth. less PLoS One, 2017 Sep 30; 12(9). PMID: 28961241 Free PMC article.
PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients. Nicholas P Tobin, Arian Lundberg, +13 authors, TEX Trialists Group. less Clin Cancer Res, 2017 Oct 04; 23(23). PMID: 28972041 Free PMC article.
Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts. Arian Lundberg, Linda S Lindström, +8 authors, Nicholas P Tobin. less Clin Cancer Res, 2017 Oct 04; 23(24). PMID: 28972043 Free PMC article.
Characterisation of the immune-related transcriptome in resected biliary tract cancers. Michele Ghidini, Luciano Cascione, +17 authors, Chiara Braconi. less Eur J Cancer, 2017 Oct 11; 86. PMID: 28988016 Free PMC article.
Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study. Katherine Lawler, Efterpi Papouli, +16 authors, Arnie Purushotham. less Breast Cancer Res, 2017 Oct 17; 19(1). PMID: 29029636 Free PMC article.
An integrated multigene expression panel to predict long-term survival after curative hepatectomy in patients with hepatocellular carcinoma. Mitsuro Kanda, Kenta Murotani, +10 authors, Yasuhiro Kodera. less Oncotarget, 2017 Oct 21; 8(41). PMID: 29050343 Free PMC article.
Use of 21-gene recurrence score assay to individualize adjuvant chemotherapy recommendations in ER+/HER2- node positive breast cancer-A National Cancer Database study. Prema P Peethambaram, Tanya L Hoskin, +3 authors, Judy C Boughey. less NPJ Breast Cancer, 2017 Oct 27; 3. PMID: 29067357 Free PMC article.
Association of 70-Gene Signature Assay Findings With Physicians' Treatment Guidance for Patients With Early Breast Cancer Classified as Intermediate Risk by the 21-Gene Assay. Michaela Tsai, Shelly Lo, +11 authors, Hatem Soliman. less JAMA Oncol, 2017 Oct 28; 4(1). PMID: 29075751 Free PMC article.
Gene Expression Profiling in Breast Cancer and Its Effect on Therapy Selection in Early-Stage Breast Cancer. E Nilüfer Güler. Eur J Breast Health, 2017 Oct 31; 13(4). PMID: 29082373 Free PMC article. Review.
Clinical utility of multigene profiling assays in early-stage breast cancer. M C Chang, L H Souter, +6 authors, Molecular Oncology Advisory Committee. less Curr Oncol, 2017 Nov 02; 24(5). PMID: 29089811 Free PMC article.
Assessing the Clinical Benefit of Systemic Adjuvant Therapies for Early Breast Cancer. Volker Möbus, Susanne Hell, Marcus Schmidt. Geburtshilfe Frauenheilkd, 2017 Nov 03; 77(10). PMID: 29093601 Free PMC article.
Chemosensitivity to doxorubicin of ER-positive/HER2-negative breast cancers with high 21-gene recurrence score: A study based on in vitro chemoresponse assay. Sung Gwe Ahn, Soong June Bae, +4 authors, Joon Jeong. less PLoS One, 2017 Nov 09; 12(11). PMID: 29117208 Free PMC article.
Discordance between oncotype DX recurrence score and RSPC for predicting residual risk of recurrence in ER-positive breast cancer. Andrew Dodson, David Okonji, +6 authors, Mitch Dowsett. less Breast Cancer Res Treat, 2017 Nov 13; 168(1). PMID: 29128896 Free PMC article.
First Prospective Multicenter Italian Study on the Impact of the 21-Gene Recurrence Score in Adjuvant Clinical Decisions for Patients with ER Positive/HER2 Negative Breast Cancer. Maria Vittoria Dieci, Valentina Guarneri, +15 authors, PierFranco Conte. less Oncologist, 2017 Nov 15; 23(3). PMID: 29133514 Free PMC article.
Prognostic value of PAM50 and risk of recurrence score in patients with early-stage breast cancer with long-term follow-up. Hege O Ohnstad, Elin Borgen, +11 authors, Bjørn Naume. less Breast Cancer Res, 2017 Nov 16; 19(1). PMID: 29137653 Free PMC article.
A metastasis biomarker (MetaSite Breast™ Score) is associated with distant recurrence in hormone receptor-positive, HER2-negative early-stage breast cancer. Joseph A Sparano, Robert Gray, +13 authors, Joan Jones. less NPJ Breast Cancer, 2017 Nov 16; 3. PMID: 29138761 Free PMC article.
The Era of Multigene Panels Comes? The Clinical Utility of Oncotype DX and MammaPrint. Ling Xin, Yin-Hua Liu, Tracey A Martin, Wen G Jiang. World J Oncol, 2017 Nov 18; 8(2). PMID: 29147432 Free PMC article. Review.
Molecular Genomic Testing for Breast Cancer: Utility for Surgeons. Oluwadamilola M Fayanju, Ko Un Park, Anthony Lucci. Ann Surg Oncol, 2017 Nov 22; 25(2). PMID: 29159748 Free PMC article. Review.
Overexpression of suppressive microRNAs, miR-30a and miR-200c are associated with improved survival of breast cancer patients. Tsutomu Kawaguchi, Li Yan, +5 authors, Kazuaki Takabe. less Sci Rep, 2017 Nov 23; 7(1). PMID: 29162923 Free PMC article.
Diffusion-weighted MRI characteristics associated with prognostic pathological factors and recurrence risk in invasive ER+/HER2- breast cancers. Nita Amornsiripanitch, Vicky T Nguyen, +4 authors, Savannah C Partridge. less J Magn Reson Imaging, 2017 Nov 28; 48(1). PMID: 29178616 Free PMC article.
Large-scale DNA organization is a prognostic marker of breast cancer survival. Martial Guillaud, Qian Ye, +5 authors, Mira Keyes. less Med Oncol, 2017 Dec 08; 35(1). PMID: 29214466
Validation Study of the American Joint Committee on Cancer Eighth Edition Prognostic Stage Compared With the Anatomic Stage in Breast Cancer. Anna Weiss, Mariana Chavez-MacGregor, +6 authors, Elizabeth A Mittendorf. less JAMA Oncol, 2017 Dec 10; 4(2). PMID: 29222540 Free PMC article.
Recent Trends in Chemotherapy Use and Oncologists' Treatment Recommendations for Early-Stage Breast Cancer. Allison W Kurian, Irina Bondarenko, +7 authors, Steven J Katz. less J Natl Cancer Inst, 2017 Dec 14; 110(5). PMID: 29237009 Free PMC article.
Biomarkers in breast cancer: A consensus statement by the Spanish Society of Medical Oncology and the Spanish Society of Pathology. R Colomer, I Aranda-López, +7 authors, J Palacios-Calvo. less Clin Transl Oncol, 2017 Dec 24; 20(7). PMID: 29273958 Free PMC article. Review.
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer. Satbir Singh Thakur, Haocheng Li, +5 authors, Hua Yang. less PLoS One, 2018 Jan 06; 13(1). PMID: 29304138 Free PMC article.
Breast carcinoma with 21-gene recurrence score lower than 18: rate of locoregional recurrence in a large series with clinical follow-up. Gulisa Turashvili, Edi Brogi, +4 authors, Hannah Y Wen. less BMC Cancer, 2018 Jan 07; 18(1). PMID: 29304773 Free PMC article.
Luminal-like HER2-negative stage IA breast cancer: a multicenter retrospective study on long-term outcome with propensity score analysis. Carmine De Angelis, Massimo Di Maio, +12 authors, Grazia Arpino. less Oncotarget, 2018 Jan 20; 8(68). PMID: 29348868 Free PMC article.
Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment. Corey Speers, Lori J Pierce. Int J Breast Cancer, 2018 Jan 20; 2017. PMID: 29348942 Free PMC article. Review.
Prospective Evaluation of the Impact of the 21-Gene Recurrence Score Assay on Adjuvant Treatment Decisions for Women with Node-Positive Breast Cancer in Ontario, Canada. Sofia Torres, Maureen Trudeau, +7 authors, Andrea Eisen. less Oncologist, 2018 Jan 27; 23(7). PMID: 29371476 Free PMC article.
The new TNM-based staging of breast cancer. Gábor Cserni, Ewa Chmielik, Bálint Cserni, Tibor Tot. Virchows Arch, 2018 Jan 31; 472(5). PMID: 29380126 Highly Cited. Review.
Breast Cancer in Low- and Middle-Income Countries: Why We Need Pathology Capability to Solve This Challenge. Yehoda M Martei, Lydia E Pace, Jane E Brock, Lawrence N Shulman. Clin Lab Med, 2018 Feb 08; 38(1). PMID: 29412880 Free PMC article. Review.
Luminal A Breast Cancer and Molecular Assays: A Review. Jennifer J Gao, Sandra M Swain. Oncologist, 2018 Feb 24; 23(5). PMID: 29472313 Free PMC article. Review.
Spotlight on the utility of the Oncotype DX® breast cancer assay. Zhen Rong Siow, Richard H De Boer, Geoffrey J Lindeman, G Bruce Mann. Int J Womens Health, 2018 Mar 06; 10. PMID: 29503586 Free PMC article. Review.
The 21-Gene Recurrence Score in Male Breast Cancer. Gulisa Turashvili, Monica Gonzalez-Loperena, +4 authors, Hannah Y Wen. less Ann Surg Oncol, 2018 Mar 10; 25(6). PMID: 29520654 Free PMC article.
Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer. Sung Gwe Ahn, Yoon Jin Cha, +3 authors, Joon Jeong. less BMC Cancer, 2018 Mar 27; 18(1). PMID: 29573739 Free PMC article.
Update Breast Cancer 2018 (Part 1) - Primary Breast Cancer and Biomarkers. Florin-Andrei Taran, Andreas Schneeweiss, +19 authors, Florian Schütz. less Geburtshilfe Frauenheilkd, 2018 Mar 27; 78(3). PMID: 29576629 Free PMC article.
Understanding Biomarkers in Early-Stage Invasive Breast Cancer: Tools From the ASCO Clinical Guideline. Kelley D Mayden. J Adv Pract Oncol, 2016 Sep 01; 7(6). PMID: 29588871 Free PMC article. Review.
Cost-Effectiveness Analyses of the 21-Gene Assay in Breast Cancer: Systematic Review and Critical Appraisal. Shi-Yi Wang, Weixiong Dang, +3 authors, Cary P Gross. less J Clin Oncol, 2018 Apr 17; 36(16). PMID: 29659329 Free PMC article. Systematic Review.
Practice patterns and outcomes for patients with node-negative hormone receptor-positive breast cancer and intermediate 21-gene Recurrence Scores. Jonathan Chen, Xian Wu, +2 authors, Paul J Christos, Silvia Formenti, Himanshu Nagar. less Breast Cancer Res, 2018 Apr 18; 20(1). PMID: 29661221 Free PMC article.
A novel dual-marker expression panel for easy and accurate risk stratification of patients with gastric cancer. Mitsuro Kanda, Kenta Murotani, +11 authors, Yasuhiro Kodera. less Cancer Med, 2018 May 08; 7(6). PMID: 29733517 Free PMC article.
Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes. Arthur Winer, Sylvia Adams, Paolo Mignatti. Molecular cancer therapeutics, 2018 May 08; 17(6). PMID: 29735645 Free PMC article. Highly Cited. Review.
Contralateral parenchymal enhancement on dynamic contrast-enhanced MRI reproduces as a biomarker of survival in ER-positive/HER2-negative breast cancer patients. Bas H M van der Velden, Elizabeth J Sutton, +3 authors, Kenneth G A Gilhuijs. less Eur Radiol, 2018 May 08; 28(11). PMID: 29736850 Free PMC article.
Anthracycline Use for Early Stage Breast Cancer in the Modern Era: a Review. Sakshi Jasra, Jesus Anampa. Curr Treat Options Oncol, 2018 May 13; 19(6). PMID: 29752560 Review.
Combined pathologic-genomic algorithm for early-stage breast cancer improves cost-effective use of the 21-gene recurrence score assay. M M Gage, W C Mylander, +9 authors, R S Jackson. less Ann Oncol, 2018 May 23; 29(5). PMID: 29788166 Free PMC article.
Prognostic gene expression assays in breast cancer: are two better than one? Joseph A Sparano. NPJ Breast Cancer, 2018 May 31; 4. PMID: 29845110 Free PMC article.
Quantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer. Jon Whitney, German Corredor, +6 authors, Anant Madabhushi. less BMC Cancer, 2018 Jun 01; 18(1). PMID: 29848291 Free PMC article.
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer. Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge. less N Engl J Med, 2018 Jun 05; 379(2). PMID: 29860917 Free PMC article. Highly Cited.
A nomogram to predict adjuvant chemotherapy recommendation in breast cancer patients with intermediate recurrence score. Feilin Qu, Xiaosong Chen, +10 authors, Kunwei Shen. less Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861607 Free PMC article.
Clinical application and utility of genomic assays in early-stage breast cancer: key lessons learned to date. S K L Chia. Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910655 Free PMC article. Review.
Integrating Radiosensitivity and Immune Gene Signatures for Predicting Benefit of Radiotherapy in Breast Cancer. Yi Cui, Bailiang Li, +2 authors, Erqi L Pollom, Kathleen C Horst, Ruijiang Li. less Clin Cancer Res, 2018 Jun 21; 24(19). PMID: 29921729 Free PMC article.
Lymph Node Status in Breast Cancer Does Not Predict Tumor Biology. Danielle M Bello, Christy Russell, +2 authors, Debbie McCullough, Marni Tierno, Monica Morrow. less Ann Surg Oncol, 2018 Jul 04; 25(10). PMID: 29968028 Free PMC article.
Should age impact breast cancer management in young women? Fine tuning of treatment guidelines. Matteo B Suter, Olivia Pagani. Ther Adv Med Oncol, 2018 Jul 07; 10. PMID: 29977348 Free PMC article. Review.
Personalizing Radiation Treatment Delivery in the Management of Breast Cancer. Kamran A Ahmed, G Daniel Grass, +7 authors, Roberto Diaz. less Int J Breast Cancer, 2018 Jul 10; 2018. PMID: 29984003 Free PMC article. Review.
Using Probability for Pathological Complete Response (pCR) as a Decision Support Marker for Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer Patients - a Survey Among Physicians. Paul Gass, Michael Untch, +18 authors, Naiba Nabieva. less Geburtshilfe Frauenheilkd, 2018 Jul 31; 78(7). PMID: 30057427 Free PMC article.
Breast Cancers of Special Histologic Subtypes Are Biologically Diverse. Audree B Tadros, Hannah Y Wen, Monica Morrow. Ann Surg Oncol, 2018 Aug 11; 25(11). PMID: 30094484 Free PMC article.
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Adjuvant Anthracyclines in Breast Cancer: What Is Their Role? Ami N Shah, William J Gradishar. Oncologist, 2018 Aug 19; 23(10). PMID: 30120159 Free PMC article. Review.
A response prediction model for taxane, cisplatin, and 5-fluorouracil chemotherapy in hypopharyngeal carcinoma. Qi Zhong, Jugao Fang, +10 authors, Yingduan Cheng. less Sci Rep, 2018 Aug 25; 8(1). PMID: 30139993 Free PMC article.
Clinical relevance of the 21-gene Recurrence Score® assay in treatment decisions for patients with node-positive breast cancer in the genomic era. Eleftherios P Mamounas, Christy A Russell, +2 authors, Anna Lau, Michelle P Turner, Kathy S Albain. less NPJ Breast Cancer, 2018 Aug 30; 4. PMID: 30155517 Free PMC article. Review.
Genomic Testing in the Management of Early-Stage Breast Cancer. Sima Ehsani, Kari Braun Wisinski. J Clin Outcomes Manag, 2017 May 01; 24(5). PMID: 30158821 Free PMC article.
RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer-From Cell Line Models to Liquid Biopsies. Marvin C J Lim, Anne-Marie Baird, +5 authors, Stephen P Finn. less Diagnostics (Basel), 2018 Sep 12; 8(3). PMID: 30200254 Free PMC article. Review.
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers. André Filipe Vieira, Fernando Schmitt. Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119 Free PMC article. Review.
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An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA project. Giacomo Pelizzari, Grazia Arpino, +8 authors, Fabio Puglisi. less BMC Cancer, 2018 Sep 29; 18(1). PMID: 30261866 Free PMC article.
Distribution and Clinical Utility of the 21-gene Recurrence Score in Pure Mucinous Breast Cancer Patients: a case-control study. Wei Wang, Xiaosong Chen, +12 authors, Kunwei Shen. less J Cancer, 2018 Oct 03; 9(18). PMID: 30271480 Free PMC article.
Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer. Yesim Gökmen-Polar, Jason D True, +5 authors, Sunil S Badve. less PLoS One, 2018 Oct 03; 13(10). PMID: 30278072 Free PMC article.
Increased derived neutrophil-to-lymphocyte ratio and Breast Imaging-Reporting and Data System classification predict poor survival in patients with non-distant metastatic HER2+ breast cancer treated with neoadjuvant chemotherapy. Yuyong Li, Yi Shao, Lishan Bai, Xingwei Zhou. Cancer Manag Res, 2018 Oct 06; 10. PMID: 30288115 Free PMC article.
Novel MicroRNA-Based Risk Score Identified by Integrated Analyses to Predict Metastasis and Poor Prognosis in Breast Cancer. Tstutomu Kawaguchi, Li Yan, +7 authors, Kazuaki Takabe. less Ann Surg Oncol, 2018 Oct 13; 25(13). PMID: 30311168 Free PMC article.
Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer. Jiwoong Jung, Young Jin Suh, +5 authors, Ki-Tae Hwang. less Cancer Med, 2018 Oct 13; 7(11). PMID: 30311421 Free PMC article.
Controversial issues in radiotherapy after breast-conserving surgery for early breast cancer in older patients: a systematic review. Liuwei Tang, Haruo Matsushita, Keiichi Jingu. J Radiat Res, 2018 Oct 16; 59(6). PMID: 30321392 Free PMC article. Systematic Review.
The Prognostic Impact of Synchronous Ipsilateral Multiple Breast Cancer: Survival Outcomes according to the Eighth American Joint Committee on Cancer Staging and Molecular Subtype. Jinah Chu, Hyunsik Bae, +3 authors, Eun Yoon Cho. less J Pathol Transl Med, 2018 Oct 24; 52(6). PMID: 30347971 Free PMC article.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers. Wenyong Tan, Ming Yang, +2 authors, Hongli Yang, Fangbin Zhou, Weixi Shen. less Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367 Free PMC article. Review.
Combined Performance of Screening and Variable Selection Methods in Ultra-High Dimensional Data in Predicting Time-To-Event Outcomes. Lira Pi, Susan Halabi. Diagn Progn Res, 2018 Nov 06; 2. PMID: 30393771 Free PMC article.
Expression of miRNA-206 and miRNA-145 in breast cancer and correlation with prognosis. Yan Quan, Xianxi Huang, Xiaoxiang Quan. Oncol Lett, 2018 Nov 09; 16(5). PMID: 30405803 Free PMC article.
Prognostic role of derived neutrophil-to-lymphocyte ratio in surgical triple-negative breast cancer. Kuojun Ren, Yachao Yin, +2 authors, Fang He, Yi Shao, Shengying Wang. less Cancer Manag Res, 2018 Nov 15; 10. PMID: 30425580 Free PMC article.
Machine Learning With K-Means Dimensional Reduction for Predicting Survival Outcomes in Patients With Breast Cancer. Melissa Zhao, Yushi Tang, Hyunkyung Kim, Kohei Hasegawa. Cancer Inform, 2018 Nov 21; 17. PMID: 30455569 Free PMC article.
21-Gene assay as predictor of chemotherapy benefit in HER2-negative breast cancer. Charles E Geyer, Gong Tang, +8 authors, Norman Wolmark. less NPJ Breast Cancer, 2018 Nov 21; 4. PMID: 30456299 Free PMC article.
BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer. Mi Jeong Kwon, Sae Byul Lee, +8 authors, Young Kee Shin. less PLoS One, 2018 Nov 22; 13(11). PMID: 30462685 Free PMC article.
Update Breast Cancer 2018 (Part 3) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer. Achim Wöckel, Michael P Lux, +17 authors, Hans-Christian Kolberg. less Geburtshilfe Frauenheilkd, 2018 Dec 01; 78(11). PMID: 30498278 Free PMC article.
The Warwick Experience of the Oncotype DX® Breast Recurrence Score® Assay as a Predictor of Chemotherapy Administration. Mashuk Alam Khan, Laura Henderson, +2 authors, Dayalan Clarke, Simon Harries, Lucie Jones. less Breast Care (Basel), 2018 Dec 01; 13(5). PMID: 30498424 Free PMC article.
Decentralized Learning Framework of Meta-Survival Analysis for Developing Robust Prognostic Signatures. Yi Cui, Bailiang Li, Ruijiang Li. JCO Clin Cancer Inform, 2017 Nov 01; 1. PMID: 30657395 Free PMC article.
Adjuvant Systemic Treatment of Premenopausal Women With Hormone Receptor-Positive Early Breast Cancer: Lights and Shadows. Meredith M Regan, Gini F Fleming, +2 authors, Barbara Walley, Prudence A Francis, Olivia Pagani. less J Clin Oncol, 2019 Feb 28; 37(11). PMID: 30811287 Free PMC article.
Impact of 21-Gene Recurrence Score on Chemotherapy Decision in Invasive Ductal Carcinoma of Breast with Nodal Micrometastases. Wei-Rong Chen, Jia-Peng Deng, +3 authors, Jun Wang, Jia-Yuan Sun, Zhen-Yu He, San-Gang Wu. less Cancer Res Treat, 2019 Mar 28; 51(4). PMID: 30913871 Free PMC article.
Evaluation of the Incorporation of Recurrence Score into the American Joint Committee on Cancer Eighth Edition Staging System in Patients with T1-2N0M0, Estrogen Receptor-Positive, Human Epidermal Growth Receptor 2-Negative Invasive Breast Cancer: A Population-Based Analysis. Shuning Ding, Jiayi Wu, +6 authors, Li Zhu. less Oncologist, 2019 Apr 26; 24(11). PMID: 31019021 Free PMC article.
Impact of 21-Gene Breast Cancer Assay on Treatment Decision for Patients with T1-T3, N0-N1, Estrogen Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Breast Cancer: Final Results of the Prospective Multicenter ROXANE Study. Maria Vittoria Dieci, Valentina Guarneri, +16 authors, Veneto Oncology Network. less Oncologist, 2019 Jun 04; 24(11). PMID: 31152079 Free PMC article.
The effect of Oncotype DX® on adjuvant chemotherapy treatment decisions in early breast cancer. M A Rabie, A Rankin, A Burger, Mmg Youssef. Ann R Coll Surg Engl, 2019 Jun 21; 101(8). PMID: 31219316 Free PMC article.
Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer. Mark P Labrecque, Ilsa M Coleman, +19 authors, Colm Morrissey. less J Clin Invest, 2019 Jul 31; 129(10). PMID: 31361600 Free PMC article.
Diffusion-weighted MRI of estrogen receptor-positive, HER2-negative, node-negative breast cancer: association between intratumoral heterogeneity and recurrence risk. Jin You Kim, Jin Joo Kim, +8 authors, Robert Grimm. less Eur Radiol, 2019 Aug 07; 30(1). PMID: 31385051
Panoptic View of Prognostic Models for Personalized Breast Cancer Management. Geetanjali Saini, Karuna Mittal, +3 authors, Ritu Aneja. less Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500225 Free PMC article. Review.
Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial. Joseph A Sparano, Robert J Gray, +26 authors, George W Sledge. less JAMA Oncol, 2019 Oct 01; 6(3). PMID: 31566680 Free PMC article.
21-Gene recurrence score influences the chemotherapy decision for patients with breast cancer of different luminal subtypes. Wei Wang, Lin Lin, +11 authors, Kunwei Shen. less Oncol Lett, 2019 Oct 04; 18(4). PMID: 31579428 Free PMC article.
Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26-30. Seho Park, Yunan Han, +7 authors, Yikyung Park. less Breast Cancer Res, 2019 Oct 18; 21(1). PMID: 31619259 Free PMC article.
Update Breast Cancer 2019 Part 4 - Diagnostic and Therapeutic Challenges of New, Personalised Therapies for Patients with Early Breast Cancer. Florian Schütz, Peter A Fasching, +16 authors, Volkmar Müller. less Geburtshilfe Frauenheilkd, 2019 Oct 28; 79(10). PMID: 31656318 Free PMC article.
Development and internal validation of a Nomogram for preoperative prediction of surgical treatment effect on cesarean section diverticulum. Yizhi Wang, Qinyi Zhu, +3 authors, Feikai Lin, Li Xie, Jiarui Li, Xipeng Wang. less BMC Womens Health, 2019 Nov 13; 19(1). PMID: 31711470 Free PMC article.
Treatment of Early Breast Cancer Patients: Evidence, Controversies, Consensus: Focusing on Systemic Therapy - German Experts' Opinions for the 16th International St. Gallen Consensus Conference (Vienna 2019). Diana Lüftner, Ingo Bauerfeind, +21 authors, Marc Thill. less Breast Care (Basel), 2019 Dec 05; 14(5). PMID: 31798392 Free PMC article. Review.
Decision of Adjuvant Systemic Treatment in HR+ HER2- Early Invasive Breast Cancer: Which Biomarkers Could Help? Marie Alexandre, Aurélie Maran-Gonzalez, +6 authors, Séverine Guiu. less Cancer Manag Res, 2019 Dec 19; 11. PMID: 31849525 Free PMC article. Review.
The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer. Qiancheng Du, Yanyan Wang, +8 authors, Ying Zhou. less Sci Rep, 2019 Dec 20; 9(1). PMID: 31852926 Free PMC article.
Decentralization of Next-Generation RNA Sequencing-Based MammaPrint® and BluePrint® Kit at University Hospitals Leuven and Curie Institute Paris. Laurence Slembrouck, Lauren Darrigues, +31 authors, Giuseppe Floris. less Transl Oncol, 2019 Sep 13; 12(12). PMID: 31513983 Free PMC article.
RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery. Nathan D Pennock, Sonali Jindal, +10 authors, Zheng Xia. less BMC Med Genomics, 2019 Dec 21; 12(1). PMID: 31856832 Free PMC article.
A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer. Vincent T Wu, Boris Kiriazov, +13 authors, Ronald J Weigel. less Mol Cancer Res, 2019 Oct 18; 18(1). PMID: 31619506 Free PMC article.
Omission of Chemotherapy for the Treatment of Mucinous Breast Cancer: A Nationwide Study from the Korean Breast Cancer Society. Hyung Suk Kim, Jong Uk Lee, +4 authors, Woo Chan Park. less J Breast Cancer, 2020 Jan 04; 22(4). PMID: 31897333 Free PMC article.
Impact of deviation from guideline recommended treatment on breast cancer survival in Asia. Peh Joo Ho, Samuel Guan Wei Ow, +12 authors, Mikael Hartman. less Sci Rep, 2020 Jan 30; 10(1). PMID: 31992769 Free PMC article.
Evaluation of Prognosis in Hormone Receptor-Positive/HER2-Negative and Lymph Node-Negative Breast Cancer With Low Oncotype DX Recurrence Score. Jane Meisel, Chao Zhang, +7 authors, Xiaoxian Li. less Clin Breast Cancer, 2018 Jan 07; 18(5). PMID: 29305309 Free PMC article.
Clinicopathologic analysis of 722 breast cancer patients who met the inclusion criteria of the TAILORx trial. Hong-Yu Xiang, Yin-Hua Liu, +7 authors, Qian Liu. less Chin Med J (Engl), 2019 Dec 07; 132(24). PMID: 31809316 Free PMC article.
Predicting the response to neoadjuvant chemotherapy for breast cancer: wavelet transforming radiomics in MRI. Jiali Zhou, Jinghui Lu, +5 authors, Maosheng Xu. less BMC Cancer, 2020 Feb 07; 20(1). PMID: 32024483 Free PMC article.
Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers. Sherene Loi, Damien Drubay, +19 authors, Stefan Michiels. less J Clin Oncol, 2019 Jan 17; 37(7). PMID: 30650045 Free PMC article. Highly Cited.
Development of an Immune-Related Prognostic Signature in Breast Cancer. Peiling Xie, Yuying Ma, +3 authors, Shibo Yu, Rui An, Jianjun He, Huimin Zhang. less Front Genet, 2020 Feb 13; 10. PMID: 32047513 Free PMC article.
Expected Monetary Impact of Oncotype DX Score-Concordant Systemic Breast Cancer Therapy Based on the TAILORx Trial. Angela Mariotto, Jinani Jayasekerea, +5 authors, Jeanne S Mandelblatt. less J Natl Cancer Inst, 2019 Jun 06; 112(2). PMID: 31165854 Free PMC article.
Comparison of 21-gene assay and St.Gallen International Expert Consensus in the treatment decision for patients with early invasive breast cancers. Ming Luo, Fu Li, +2 authors, Ka Su, Huiming Yuan, Jian Zeng. less Cancer biology & therapy, 2019 Oct 31; 21(2). PMID: 31663437 Free PMC article.
Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer. Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge. less N Engl J Med, 2019 Jun 04; 380(25). PMID: 31157962 Free PMC article. Highly Cited.
Prognostic Impact of the 21-Gene Recurrence Score Assay Among Young Women With Node-Negative and Node-Positive ER-Positive/HER2-Negative Breast Cancer. Philip D Poorvu, Shari I Gelber, +12 authors, Ann H Partridge. less J Clin Oncol, 2019 Dec 07; 38(7). PMID: 31809240 Free PMC article.
Adjuvant chemotherapy could not bring survival benefit to HR-positive, HER2-negative, pT1b-c/N0-1/M0 invasive lobular carcinoma of the breast: a propensity score matching study based on SEER database. Guangfu Hu, Guangxia Hu, +8 authors, Cheng Xu. less BMC Cancer, 2020 Feb 23; 20(1). PMID: 32085753 Free PMC article.
Use and Impact of the 21-Gene Recurrence Score in Relation to the Clinical Risk of Developing Metastases in Early Breast Cancer Patients in the Netherlands. Kay Schreuder, Anne Kuijer, +2 authors, Sanne Bentum, Thijs van Dalen, Sabine Siesling. less Public Health Genomics, 2019 Jan 17; 21(1-2). PMID: 30650410 Free PMC article.
21-Gene Recurrence Score and Adjuvant Chemotherapy Decision for Breast Cancer Patients with Positive Lymph Nodes. Yiwei Tong, Jiayi Wu, +6 authors, Kunwei Shen. less Sci Rep, 2019 Sep 13; 9(1). PMID: 31511599 Free PMC article.
Racial Differences in 21-Gene Recurrence Scores Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer. Andreana N Holowatyj, Michele L Cote, +5 authors, Kristen S Purrington. less J Clin Oncol, 2018 Jan 18; 36(7). PMID: 29341832 Free PMC article.
Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer. Diana C West, Masha Kocherginsky, +20 authors, Suzanne D Conzen. less Clin Cancer Res, 2018 Apr 11; 24(14). PMID: 29636357 Free PMC article.
Simulation Modeling of Cancer Clinical Trials: Application to Omitting Radiotherapy in Low-risk Breast Cancer. Jinani Jayasekera, Yisheng Li, +21 authors, CISNET-BOLD Collaborative Group. less J Natl Cancer Inst, 2018 May 03; 110(12). PMID: 29718314 Free PMC article.
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Effects of Radiotherapy in Early-Stage, Low-Recurrence Risk, Hormone-Sensitive Breast Cancer. Jinani Jayasekera, Clyde B Schechter, +17 authors, CISNET-BOLD Collaborative Group. less J Natl Cancer Inst, 2018 Sep 22; 110(12). PMID: 30239794 Free PMC article.
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Implications for Breast Cancer Restaging Based on the 8th Edition AJCC Staging Manual. Jennifer K Plichta, Yi Ren, +5 authors, E Shelley Hwang. less Ann Surg, 2018 Oct 13; 271(1). PMID: 30312199 Free PMC article.
Challenging the heterogeneity of disease presentation in malignant melanoma-impact on patient treatment. A Marcell Szasz, Johan Malm, +5 authors, György Marko-Varga. less Cell Biol Toxicol, 2018 Oct 26; 35(1). PMID: 30357519 Free PMC article. Review.
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Introduction of a New Staging System of Breast Cancer for Radiologists: An Emphasis on the Prognostic Stage. Jieun Koh, Min Jung Kim. Korean J Radiol, 2019 Jan 11; 20(1). PMID: 30627023 Free PMC article.
Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives. Andy Dahl, Vincent Guillemot, +2 authors, Joel Mefford, Hugues Aschard, Noah Zaitlen. less Genetics, 2019 Jan 30; 211(4). PMID: 30692194 Free PMC article.
A novel six-microRNA-based model to improve prognosis prediction of breast cancer. Jianguo Lai, Hongli Wang, Zihao Pan, Fengxi Su. Aging (Albany NY), 2019 Jan 31; 11(2). PMID: 30696800 Free PMC article.
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Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target. Pei-Yu Chu, Yu-Ling Tai, Tang-Long Shen. Cells, 2019 May 15; 8(5). PMID: 31083325 Free PMC article. Review.
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Oncotype DX: Where Does It Stand in India? Atul Batra, Amol Patel, +6 authors, Priyanka Srivastava. less J Glob Oncol, 2019 Jul 17; 5. PMID: 31310569 Free PMC article.
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Risk stratification of ER-positive breast cancer patients: A multi-institutional validation and outcome study of the Rochester Modified Magee algorithm (RoMMa) and prediction of an Oncotype DX® recurrence score <26. Bradley M Turner, Mary Ann Gimenez-Sanders, +6 authors, David G Hicks. less Cancer Med, 2019 Jun 15; 8(9). PMID: 31199586 Free PMC article.
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21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort. J Bryan Iorgulescu, Rachel A Freedman, +2 authors, Jane E Brock. less JCO Precis Oncol, 2019 Jan 01; 3. PMID: 32457931 Free PMC article.
Do 21-Gene Recurrence Score Influence Chemotherapy Decisions in T1bN0 Breast Cancer Patients? Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen. less Front Oncol, 2020 Jun 02; 10. PMID: 32477946 Free PMC article.
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