Journal Article
. 2015 Sep;373(21).
doi: 10.1056/NEJMoa1510764.

Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

Joseph A Sparano 1 Robert J Gray  Della F Makower  Kathleen I Pritchard  Kathy S Albain  Daniel F Hayes  Charles E Geyer  Elizabeth C Dees  Edith A Perez  John A Olson  JoAnne Zujewski  Tracy Lively  Sunil S Badve  Thomas J Saphner  Lynne I Wagner  Timothy J Whelan  Matthew J Ellis  Soonmyung Paik  William C Wood  Peter Ravdin  Maccon M Keane  Henry L Gomez Moreno  Pavan S Reddy  Timothy F Goggins  Ingrid A Mayer  Adam M Brufsky  Deborah L Toppmeyer  Virginia G Kaklamani  James N Atkins  Jeffrey L Berenberg  George W Sledge  
Affiliations
  • PMID: 26412349
  •     37 References
  •     322 citations

Abstract

Background: Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker.

Methods: We performed a prospective trial involving women with hormone-receptor-positive, human epidermal growth factor receptor type 2 (HER2)-negative, axillary node-negative breast cancer with tumors of 1.1 to 5.0 cm in the greatest dimension (or 0.6 to 1.0 cm in the greatest dimension and intermediate or high tumor grade) who met established guidelines for the consideration of adjuvant chemotherapy on the basis of clinicopathologic features. A reverse-transcriptase-polymerase-chain-reaction assay of 21 genes was performed on the paraffin-embedded tumor tissue, and the results were used to calculate a score indicating the risk of breast-cancer recurrence; patients were assigned to receive endocrine therapy without chemotherapy if they had a recurrence score of 0 to 10, indicating a very low risk of recurrence (on a scale of 0 to 100, with higher scores indicating a greater risk of recurrence).

Results: Of the 10,253 eligible women enrolled, 1626 women (15.9%) who had a recurrence score of 0 to 10 were assigned to receive endocrine therapy alone without chemotherapy. At 5 years, in this patient population, the rate of invasive disease-free survival was 93.8% (95% confidence interval [CI], 92.4 to 94.9), the rate of freedom from recurrence of breast cancer at a distant site was 99.3% (95% CI, 98.7 to 99.6), the rate of freedom from recurrence of breast cancer at a distant or local-regional site was 98.7% (95% CI, 97.9 to 99.2), and the rate of overall survival was 98.0% (95% CI, 97.1 to 98.6).

Conclusions: Among patients with hormone-receptor-positive, HER2-negative, axillary node-negative breast cancer who met established guidelines for the recommendation of adjuvant chemotherapy on the basis of clinicopathologic features, those with tumors that had a favorable gene-expression profile had very low rates of recurrence at 5 years with endocrine therapy alone. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00310180.).

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Outcomes in patients with early-stage breast cancer who underwent a 21-gene expression assay.
Carlos H Barcenas, Akshara Raghavendra, +10 authors, Debu Tripathy.
Cancer, 2017 Feb 16; 123(13). PMID: 28199747    Free PMC article.
Epidemiology and survival outcome of breast cancer in a nationwide study.
Fu-Chao Liu, Huan-Tang Lin, +3 authors, Huang-Ping Yu.
Oncotarget, 2017 Feb 16; 8(10). PMID: 28199975    Free PMC article.
Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays.
David M Hyams, Eric Schuur, +7 authors, Aníbal Nuñez De Pierro.
J Surg Oncol, 2017 Feb 18; 115(6). PMID: 28211064    Free PMC article.
Review.
Oncotype DX breast cancer recurrence score can be predicted with a novel nomogram using clinicopathologic data.
Amila Orucevic, John L Bell, Alison P McNabb, Robert E Heidel.
Breast Cancer Res Treat, 2017 Mar 01; 163(1). PMID: 28243897    Free PMC article.
Correlations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkey.
Vahit Özmen, Ajlan Atasoy, +9 authors, Pınar Saip.
J Breast Health, 2016 Jan 01; 12(3). PMID: 28331745    Free PMC article.
21-Gene recurrence score testing among Medicare beneficiaries with breast cancer in 2010-2013.
Julie A Lynch, Brygida Berse, Nicole Coomer, John Kautter.
Genet Med, 2017 Mar 24; 19(10). PMID: 28333918
Distribution patterns of 21-gene recurrence score in 980 Chinese estrogen receptor-positive, HER2-negative early breast cancer patients.
Jiayi Wu, Yan Fang, +11 authors, Kunwei Shen.
Oncotarget, 2017 Apr 14; 8(24). PMID: 28404972    Free PMC article.
Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.
Kathryn A Phillips, Patricia A Deverka, +6 authors, Michael P Douglas.
Genet Med, 2017 Apr 14; 19(10). PMID: 28406488    Free PMC article.
Review.
Using the 21-gene assay from core needle biopsies to choose neoadjuvant therapy for breast cancer: A multicenter trial.
Harry D Bear, Wen Wan, +8 authors, Amy P Sing.
J Surg Oncol, 2017 Apr 14; 115(8). PMID: 28407247    Free PMC article.
Adjuvant treatment recommendations for patients with ER-positive/HER2-negative early breast cancer by Swiss tumor boards using the 21-gene recurrence score (SAKK 26/10).
Bernhard C Pestalozzi, Christoph Tausch, +17 authors, Swiss Group for Clinical Cancer Research (SAKK).
BMC Cancer, 2017 Apr 15; 17(1). PMID: 28407750    Free PMC article.
Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer.
Tristan Gallenne, Kenneth N Ross, +6 authors, Daniel S Peeper.
Oncotarget, 2017 Apr 16; 8(13). PMID: 28411283    Free PMC article.
Immunohistochemical Ki67 after short-term hormone therapy identifies low-risk breast cancers as reliably as genomic markers.
Takayuki Iwamoto, Toyomasa Katagiri, +12 authors, Junji Matsuoka.
Oncotarget, 2017 Apr 17; 8(16). PMID: 28412725    Free PMC article.
Comparison of standardized uptake value of 18F-FDG-PET-CT with 21-gene recurrence score in estrogen receptor-positive, HER2-negative breast cancer.
Sung Gwe Ahn, Jae-Hoon Lee, +8 authors, Seung Il Kim.
PLoS One, 2017 Apr 19; 12(4). PMID: 28419166    Free PMC article.
"Targeted" Chemotherapy for Esophageal Cancer.
Joe Abdo, Devendra K Agrawal, Sumeet K Mittal.
Front Oncol, 2017 Apr 20; 7. PMID: 28421164    Free PMC article.
Limitations of Personalized Medicine and Gene Assays for Breast Cancer.
David Tiberi, Laura Masucci, +5 authors, Philip Wong.
Cureus, 2017 Apr 22; 9(3). PMID: 28428927    Free PMC article.
Current Update of Patient-Derived Xenograft Model for Translational Breast Cancer Research.
Tsutomu Kawaguchi, Barbara A Foster, Jessica Young, Kazuaki Takabe.
J Mammary Gland Biol Neoplasia, 2017 Apr 30; 22(2). PMID: 28451789    Free PMC article.
Review.
Inferring gene regulatory relationships with a high-dimensional robust approach.
Yangguang Zang, Qing Zhao, +3 authors, Shuangge Ma.
Genet Epidemiol, 2017 May 04; 41(5). PMID: 28464328    Free PMC article.
An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®.
Zsuzsanna Varga, Annette Lebeau, +18 authors, Giuseppe Viale.
Breast Cancer Res, 2017 May 12; 19(1). PMID: 28490348    Free PMC article.
Uptake of a 21-gene expression assay in breast cancer practice: views of academic and community-based oncologists.
M A O'Brien, S Dhesy-Thind, +3 authors, E Grunfeld.
Curr Oncol, 2017 May 12; 24(2). PMID: 28490937    Free PMC article.
Neoadjuvant Trials in ER+ Breast Cancer: A Tool for Acceleration of Drug Development and Discovery.
Angel L Guerrero-Zotano, Carlos L Arteaga.
Cancer Discov, 2017 May 13; 7(6). PMID: 28495849    Free PMC article.
Review.
Clinical utility of gene-expression signatures in early stage breast cancer.
Maryann Kwa, Andreas Makris, Francisco J Esteva.
Nat Rev Clin Oncol, 2017 Jun 01; 14(10). PMID: 28561071
Highly Cited. Review.
Unmet Needs in Clinical Research in Breast Cancer: Where Do We Need to Go?
Ann H Partridge, Lisa A Carey.
Clin Cancer Res, 2017 Jun 03; 23(11). PMID: 28572255    Free PMC article.
The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis.
Gulisa Turashvili, Edi Brogi, +4 authors, Hannah Y Wen.
Breast Cancer Res Treat, 2017 Jun 04; 165(1). PMID: 28577081    Free PMC article.
RAS pathway biomarkers for breast cancer prognosis.
Lauren L Siewertsz van Reesema, Michael P Lee, +5 authors, Amy H Tang.
Clin Lab Int, 2017 Jun 06; 40. PMID: 28579913    Free PMC article.
The role of skin ulceration in breast carcinoma staging and outcome.
Thaer Khoury, Carmelo Gaudioso, +8 authors, Rebecca Jacobson.
Breast J, 2017 Jun 10; 24(1). PMID: 28597587    Free PMC article.
Clinical use of the Oncotype DX genomic test to guide treatment decisions for patients with invasive breast cancer.
Terri P McVeigh, Michael J Kerin.
Breast Cancer (Dove Med Press), 2017 Jun 16; 9. PMID: 28615971    Free PMC article.
Review.
Neoadjuvant Therapy for Breast Cancer: Established Concepts and Emerging Strategies.
Tessa G Steenbruggen, Mette S van Ramshorst, +3 authors, Gabe S Sonke.
Drugs, 2017 Jun 16; 77(12). PMID: 28616845
Review.
Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm.
Daniel J McGrail, Curtis Chun-Jen Lin, +11 authors, Shiaw-Yih Lin.
NPJ Syst Biol Appl, 2017 Jun 27; 3. PMID: 28649435    Free PMC article.
Prognostic and functional role of subtype-specific tumor-stroma interaction in breast cancer.
Giuseppe Merlino, Patrizia Miodini, +3 authors, Maria Grazia Daidone.
Mol Oncol, 2017 Jul 04; 11(10). PMID: 28672102    Free PMC article.
Oncologists' influence on receipt of adjuvant chemotherapy: does it matter whom you see for treatment of curable breast cancer?
Steven J Katz, Sarah T Hawley, +4 authors, Allison W Kurian.
Breast Cancer Res Treat, 2017 Jul 10; 165(3). PMID: 28689364    Free PMC article.
21-Gene recurrence score and locoregional recurrence in lymph node-negative, estrogen receptor-positive breast cancer.
Gulisa Turashvili, Joanne F Chou, +5 authors, Hannah Y Wen.
Breast Cancer Res Treat, 2017 Jul 14; 166(1). PMID: 28702894    Free PMC article.
Comparison of Oncotype DX® Recurrence Score® with other risk assessment tools including the Nottingham Prognostic Index in the identification of patients with low-risk invasive breast cancer.
Maura Bríd Cotter, Alex Dakin, +5 authors, Cecily M Quinn.
Virchows Arch, 2017 Jul 15; 471(3). PMID: 28707056
Heterogeneous Enhancement Patterns of Tumor-adjacent Parenchyma at MR Imaging Are Associated with Dysregulated Signaling Pathways and Poor Survival in Breast Cancer.
Jia Wu, Bailiang Li, +6 authors, Ruijiang Li.
Radiology, 2017 Jul 15; 285(2). PMID: 28708462    Free PMC article.
Learning from big data: are we undertreating older women with high-risk breast cancer?
Joseph A Sparano, Hyman Muss.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721380    Free PMC article.
Breast-cancer-specific mortality in patients treated based on the 21-gene assay: a SEER population-based study.
Valentina I Petkov, Dave P Miller, +21 authors, Steven Shak.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721379    Free PMC article.
Highly Cited.
Bioscore: A Staging System for Breast Cancer Patients that Reflects the Prognostic Significance of Underlying Tumor Biology.
Elizabeth A Mittendorf, Mariana Chavez-MacGregor, +5 authors, Kelly K Hunt.
Ann Surg Oncol, 2017 Jul 21; 24(12). PMID: 28726077    Free PMC article.
Initial Treatment of Patients with Primary Breast Cancer: Evidence, Controversies, Consensus: Spectrum of Opinion of German Specialists at the 15th International St. Gallen Breast Cancer Conference (Vienna 2017).
Michael Untch, Jens Huober, +18 authors, Cornelia Liedtke.
Geburtshilfe Frauenheilkd, 2017 Aug 05; 77(6). PMID: 28769126    Free PMC article.
CKAP2 (cytoskeleton-associated protein2) is a new prognostic marker in HER2-negative luminal type breast cancer.
Sung Hoon Sim, Chang-Dae Bae, +16 authors, Jungsil Ro.
PLoS One, 2017 Aug 05; 12(8). PMID: 28771517    Free PMC article.
How to Achieve Optimal Care in Early Breast Cancer with 'Less' or 'More' Treatment.
Giuseppe Curigliano.
Breast Care (Basel), 2017 Aug 09; 12(3). PMID: 28785179    Free PMC article.
Extended Adjuvant Endocrine Therapy in Hormone Receptor-Positive Early Breast Cancer.
Dara B Bracken-Clarke, Mairi W Lucas, Michaela J Higgins.
Breast Care (Basel), 2017 Aug 09; 12(3). PMID: 28785180    Free PMC article.
Review.
What Factors Influence Women's Perceptions of their Systemic Recurrence Risk after Breast Cancer Treatment?
Kamaria L Lee, Nancy K Janz, +6 authors, Sarah T Hawley.
Med Decis Making, 2017 Aug 18; 38(1). PMID: 28814131    Free PMC article.
Adjusting for covariates in evaluating markers for selecting treatment, with application to guiding chemotherapy for treating estrogen-receptor-positive, node-positive breast cancer.
Holly Janes, Marshall D Brown, +2 authors, William E Barlow.
Contemp Clin Trials, 2017 Aug 19; 63. PMID: 28818434    Free PMC article.
De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017.
G Curigliano, H J Burstein, +52 authors, B Xu.
Ann Oncol, 2017 Aug 26; 28(8). PMID: 28838210    Free PMC article.
Highly Cited.
Implementation and Feasibility of Electronic Patient-Reported Outcome (ePRO) Data Entry in the PRAEGNANT Real-Time Advanced and Metastatic Breast Cancer Registry.
Markus Wallwiener, Felix Heindl, +28 authors, Paul Gass.
Geburtshilfe Frauenheilkd, 2017 Aug 29; 77(8). PMID: 28845051    Free PMC article.
Multiplexed analysis of fixed tissue RNA using Ligation in situ Hybridization.
Joel J Credle, Christopher Y Itoh, +11 authors, H Benjamin Larman.
Nucleic Acids Res, 2017 Sep 01; 45(14). PMID: 28854731    Free PMC article.
Validation of the 18-gene classifier as a prognostic biomarker of distant metastasis in breast cancer.
Skye Hung-Chun Cheng, Tzu-Ting Huang, +6 authors, Ben-Long Yu.
PLoS One, 2017 Sep 09; 12(9). PMID: 28886126    Free PMC article.
The genetic landscape of programmed death ligand-1 (PD-L1) alterations in head and neck cancer.
Thomas E Heineman, Adam Widman, Edward C Kuan, Maie St John.
Laryngoscope Investig Otolaryngol, 2017 Sep 13; 2(3). PMID: 28894827    Free PMC article.
Clinical outcomes in ER+ HER2 -node-positive breast cancer patients who were treated according to the Recurrence Score results: evidence from a large prospectively designed registry.
Salomon M Stemmer, Mariana Steiner, +13 authors, Noa Ben-Baruch.
NPJ Breast Cancer, 2017 Sep 14; 3. PMID: 28900632    Free PMC article.
Clinical outcomes in patients with node-negative breast cancer treated based on the recurrence score results: evidence from a large prospectively designed registry.
Salomon M Stemmer, Mariana Steiner, +21 authors, Nicky Liebermann.
NPJ Breast Cancer, 2017 Sep 14; 3. PMID: 28900633    Free PMC article.
Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer.
Chiranjeevi Padala, Mohini Aiyengar Tupurani, +13 authors, Surekha Rani Hanumanth.
PLoS One, 2017 Sep 30; 12(9). PMID: 28961241    Free PMC article.
PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients.
Nicholas P Tobin, Arian Lundberg, +13 authors, TEX Trialists Group.
Clin Cancer Res, 2017 Oct 04; 23(23). PMID: 28972041    Free PMC article.
Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts.
Arian Lundberg, Linda S Lindström, +8 authors, Nicholas P Tobin.
Clin Cancer Res, 2017 Oct 04; 23(24). PMID: 28972043    Free PMC article.
Characterisation of the immune-related transcriptome in resected biliary tract cancers.
Michele Ghidini, Luciano Cascione, +17 authors, Chiara Braconi.
Eur J Cancer, 2017 Oct 11; 86. PMID: 28988016    Free PMC article.
Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study.
Katherine Lawler, Efterpi Papouli, +16 authors, Arnie Purushotham.
Breast Cancer Res, 2017 Oct 17; 19(1). PMID: 29029636    Free PMC article.
An integrated multigene expression panel to predict long-term survival after curative hepatectomy in patients with hepatocellular carcinoma.
Mitsuro Kanda, Kenta Murotani, +10 authors, Yasuhiro Kodera.
Oncotarget, 2017 Oct 21; 8(41). PMID: 29050343    Free PMC article.
Use of 21-gene recurrence score assay to individualize adjuvant chemotherapy recommendations in ER+/HER2- node positive breast cancer-A National Cancer Database study.
Prema P Peethambaram, Tanya L Hoskin, +3 authors, Judy C Boughey.
NPJ Breast Cancer, 2017 Oct 27; 3. PMID: 29067357    Free PMC article.
Association of 70-Gene Signature Assay Findings With Physicians' Treatment Guidance for Patients With Early Breast Cancer Classified as Intermediate Risk by the 21-Gene Assay.
Michaela Tsai, Shelly Lo, +11 authors, Hatem Soliman.
JAMA Oncol, 2017 Oct 28; 4(1). PMID: 29075751    Free PMC article.
Gene Expression Profiling in Breast Cancer and Its Effect on Therapy Selection in Early-Stage Breast Cancer.
E Nilüfer Güler.
Eur J Breast Health, 2017 Oct 31; 13(4). PMID: 29082373    Free PMC article.
Review.
Clinical utility of multigene profiling assays in early-stage breast cancer.
M C Chang, L H Souter, +6 authors, Molecular Oncology Advisory Committee.
Curr Oncol, 2017 Nov 02; 24(5). PMID: 29089811    Free PMC article.
Assessing the Clinical Benefit of Systemic Adjuvant Therapies for Early Breast Cancer.
Volker Möbus, Susanne Hell, Marcus Schmidt.
Geburtshilfe Frauenheilkd, 2017 Nov 03; 77(10). PMID: 29093601    Free PMC article.
Chemosensitivity to doxorubicin of ER-positive/HER2-negative breast cancers with high 21-gene recurrence score: A study based on in vitro chemoresponse assay.
Sung Gwe Ahn, Soong June Bae, +4 authors, Joon Jeong.
PLoS One, 2017 Nov 09; 12(11). PMID: 29117208    Free PMC article.
Discordance between oncotype DX recurrence score and RSPC for predicting residual risk of recurrence in ER-positive breast cancer.
Andrew Dodson, David Okonji, +6 authors, Mitch Dowsett.
Breast Cancer Res Treat, 2017 Nov 13; 168(1). PMID: 29128896    Free PMC article.
First Prospective Multicenter Italian Study on the Impact of the 21-Gene Recurrence Score in Adjuvant Clinical Decisions for Patients with ER Positive/HER2 Negative Breast Cancer.
Maria Vittoria Dieci, Valentina Guarneri, +15 authors, PierFranco Conte.
Oncologist, 2017 Nov 15; 23(3). PMID: 29133514    Free PMC article.
Prognostic value of PAM50 and risk of recurrence score in patients with early-stage breast cancer with long-term follow-up.
Hege O Ohnstad, Elin Borgen, +11 authors, Bjørn Naume.
Breast Cancer Res, 2017 Nov 16; 19(1). PMID: 29137653    Free PMC article.
A metastasis biomarker (MetaSite Breast™ Score) is associated with distant recurrence in hormone receptor-positive, HER2-negative early-stage breast cancer.
Joseph A Sparano, Robert Gray, +13 authors, Joan Jones.
NPJ Breast Cancer, 2017 Nov 16; 3. PMID: 29138761    Free PMC article.
The Era of Multigene Panels Comes? The Clinical Utility of Oncotype DX and MammaPrint.
Ling Xin, Yin-Hua Liu, Tracey A Martin, Wen G Jiang.
World J Oncol, 2017 Nov 18; 8(2). PMID: 29147432    Free PMC article.
Review.
Molecular Genomic Testing for Breast Cancer: Utility for Surgeons.
Oluwadamilola M Fayanju, Ko Un Park, Anthony Lucci.
Ann Surg Oncol, 2017 Nov 22; 25(2). PMID: 29159748    Free PMC article.
Review.
Overexpression of suppressive microRNAs, miR-30a and miR-200c are associated with improved survival of breast cancer patients.
Tsutomu Kawaguchi, Li Yan, +5 authors, Kazuaki Takabe.
Sci Rep, 2017 Nov 23; 7(1). PMID: 29162923    Free PMC article.
Diffusion-weighted MRI characteristics associated with prognostic pathological factors and recurrence risk in invasive ER+/HER2- breast cancers.
Nita Amornsiripanitch, Vicky T Nguyen, +4 authors, Savannah C Partridge.
J Magn Reson Imaging, 2017 Nov 28; 48(1). PMID: 29178616    Free PMC article.
Large-scale DNA organization is a prognostic marker of breast cancer survival.
Martial Guillaud, Qian Ye, +5 authors, Mira Keyes.
Med Oncol, 2017 Dec 08; 35(1). PMID: 29214466
Validation Study of the American Joint Committee on Cancer Eighth Edition Prognostic Stage Compared With the Anatomic Stage in Breast Cancer.
Anna Weiss, Mariana Chavez-MacGregor, +6 authors, Elizabeth A Mittendorf.
JAMA Oncol, 2017 Dec 10; 4(2). PMID: 29222540    Free PMC article.
Recent Trends in Chemotherapy Use and Oncologists' Treatment Recommendations for Early-Stage Breast Cancer.
Allison W Kurian, Irina Bondarenko, +7 authors, Steven J Katz.
J Natl Cancer Inst, 2017 Dec 14; 110(5). PMID: 29237009    Free PMC article.
Biomarkers in breast cancer: A consensus statement by the Spanish Society of Medical Oncology and the Spanish Society of Pathology.
R Colomer, I Aranda-López, +7 authors, J Palacios-Calvo.
Clin Transl Oncol, 2017 Dec 24; 20(7). PMID: 29273958    Free PMC article.
Review.
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer.
Satbir Singh Thakur, Haocheng Li, +5 authors, Hua Yang.
PLoS One, 2018 Jan 06; 13(1). PMID: 29304138    Free PMC article.
Breast carcinoma with 21-gene recurrence score lower than 18: rate of locoregional recurrence in a large series with clinical follow-up.
Gulisa Turashvili, Edi Brogi, +4 authors, Hannah Y Wen.
BMC Cancer, 2018 Jan 07; 18(1). PMID: 29304773    Free PMC article.
Luminal-like HER2-negative stage IA breast cancer: a multicenter retrospective study on long-term outcome with propensity score analysis.
Carmine De Angelis, Massimo Di Maio, +12 authors, Grazia Arpino.
Oncotarget, 2018 Jan 20; 8(68). PMID: 29348868    Free PMC article.
Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment.
Corey Speers, Lori J Pierce.
Int J Breast Cancer, 2018 Jan 20; 2017. PMID: 29348942    Free PMC article.
Review.
Prospective Evaluation of the Impact of the 21-Gene Recurrence Score Assay on Adjuvant Treatment Decisions for Women with Node-Positive Breast Cancer in Ontario, Canada.
Sofia Torres, Maureen Trudeau, +7 authors, Andrea Eisen.
Oncologist, 2018 Jan 27; 23(7). PMID: 29371476    Free PMC article.
The new TNM-based staging of breast cancer.
Gábor Cserni, Ewa Chmielik, Bálint Cserni, Tibor Tot.
Virchows Arch, 2018 Jan 31; 472(5). PMID: 29380126
Highly Cited. Review.
Breast Cancer in Low- and Middle-Income Countries: Why We Need Pathology Capability to Solve This Challenge.
Yehoda M Martei, Lydia E Pace, Jane E Brock, Lawrence N Shulman.
Clin Lab Med, 2018 Feb 08; 38(1). PMID: 29412880    Free PMC article.
Review.
Luminal A Breast Cancer and Molecular Assays: A Review.
Jennifer J Gao, Sandra M Swain.
Oncologist, 2018 Feb 24; 23(5). PMID: 29472313    Free PMC article.
Review.
Spotlight on the utility of the Oncotype DX® breast cancer assay.
Zhen Rong Siow, Richard H De Boer, Geoffrey J Lindeman, G Bruce Mann.
Int J Womens Health, 2018 Mar 06; 10. PMID: 29503586    Free PMC article.
Review.
The 21-Gene Recurrence Score in Male Breast Cancer.
Gulisa Turashvili, Monica Gonzalez-Loperena, +4 authors, Hannah Y Wen.
Ann Surg Oncol, 2018 Mar 10; 25(6). PMID: 29520654    Free PMC article.
Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer.
Sung Gwe Ahn, Yoon Jin Cha, +3 authors, Joon Jeong.
BMC Cancer, 2018 Mar 27; 18(1). PMID: 29573739    Free PMC article.
Update Breast Cancer 2018 (Part 1) - Primary Breast Cancer and Biomarkers.
Florin-Andrei Taran, Andreas Schneeweiss, +19 authors, Florian Schütz.
Geburtshilfe Frauenheilkd, 2018 Mar 27; 78(3). PMID: 29576629    Free PMC article.
Understanding Biomarkers in Early-Stage Invasive Breast Cancer: Tools From the ASCO Clinical Guideline.
Kelley D Mayden.
J Adv Pract Oncol, 2016 Sep 01; 7(6). PMID: 29588871    Free PMC article.
Review.
Cost-Effectiveness Analyses of the 21-Gene Assay in Breast Cancer: Systematic Review and Critical Appraisal.
Shi-Yi Wang, Weixiong Dang, +3 authors, Cary P Gross.
J Clin Oncol, 2018 Apr 17; 36(16). PMID: 29659329    Free PMC article.
Systematic Review.
Practice patterns and outcomes for patients with node-negative hormone receptor-positive breast cancer and intermediate 21-gene Recurrence Scores.
Jonathan Chen, Xian Wu, +2 authors, Himanshu Nagar.
Breast Cancer Res, 2018 Apr 18; 20(1). PMID: 29661221    Free PMC article.
A novel dual-marker expression panel for easy and accurate risk stratification of patients with gastric cancer.
Mitsuro Kanda, Kenta Murotani, +11 authors, Yasuhiro Kodera.
Cancer Med, 2018 May 08; 7(6). PMID: 29733517    Free PMC article.
Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes.
Arthur Winer, Sylvia Adams, Paolo Mignatti.
Molecular cancer therapeutics, 2018 May 08; 17(6). PMID: 29735645    Free PMC article.
Highly Cited. Review.
Contralateral parenchymal enhancement on dynamic contrast-enhanced MRI reproduces as a biomarker of survival in ER-positive/HER2-negative breast cancer patients.
Bas H M van der Velden, Elizabeth J Sutton, +3 authors, Kenneth G A Gilhuijs.
Eur Radiol, 2018 May 08; 28(11). PMID: 29736850    Free PMC article.
Anthracycline Use for Early Stage Breast Cancer in the Modern Era: a Review.
Sakshi Jasra, Jesus Anampa.
Curr Treat Options Oncol, 2018 May 13; 19(6). PMID: 29752560
Review.
Combined pathologic-genomic algorithm for early-stage breast cancer improves cost-effective use of the 21-gene recurrence score assay.
M M Gage, W C Mylander, +9 authors, R S Jackson.
Ann Oncol, 2018 May 23; 29(5). PMID: 29788166    Free PMC article.
Prognostic gene expression assays in breast cancer: are two better than one?
Joseph A Sparano.
NPJ Breast Cancer, 2018 May 31; 4. PMID: 29845110    Free PMC article.
Quantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer.
Jon Whitney, German Corredor, +6 authors, Anant Madabhushi.
BMC Cancer, 2018 Jun 01; 18(1). PMID: 29848291    Free PMC article.
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge.
N Engl J Med, 2018 Jun 05; 379(2). PMID: 29860917    Free PMC article.
Highly Cited.
A nomogram to predict adjuvant chemotherapy recommendation in breast cancer patients with intermediate recurrence score.
Feilin Qu, Xiaosong Chen, +10 authors, Kunwei Shen.
Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861607    Free PMC article.
Clinical application and utility of genomic assays in early-stage breast cancer: key lessons learned to date.
S K L Chia.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910655    Free PMC article.
Review.
Integrating Radiosensitivity and Immune Gene Signatures for Predicting Benefit of Radiotherapy in Breast Cancer.
Yi Cui, Bailiang Li, +2 authors, Ruijiang Li.
Clin Cancer Res, 2018 Jun 21; 24(19). PMID: 29921729    Free PMC article.
Lymph Node Status in Breast Cancer Does Not Predict Tumor Biology.
Danielle M Bello, Christy Russell, +2 authors, Monica Morrow.
Ann Surg Oncol, 2018 Jul 04; 25(10). PMID: 29968028    Free PMC article.
Should age impact breast cancer management in young women? Fine tuning of treatment guidelines.
Matteo B Suter, Olivia Pagani.
Ther Adv Med Oncol, 2018 Jul 07; 10. PMID: 29977348    Free PMC article.
Review.
Personalizing Radiation Treatment Delivery in the Management of Breast Cancer.
Kamran A Ahmed, G Daniel Grass, +7 authors, Roberto Diaz.
Int J Breast Cancer, 2018 Jul 10; 2018. PMID: 29984003    Free PMC article.
Review.
Using Probability for Pathological Complete Response (pCR) as a Decision Support Marker for Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer Patients - a Survey Among Physicians.
Paul Gass, Michael Untch, +18 authors, Naiba Nabieva.
Geburtshilfe Frauenheilkd, 2018 Jul 31; 78(7). PMID: 30057427    Free PMC article.
Breast Cancers of Special Histologic Subtypes Are Biologically Diverse.
Audree B Tadros, Hannah Y Wen, Monica Morrow.
Ann Surg Oncol, 2018 Aug 11; 25(11). PMID: 30094484    Free PMC article.
Overview of Breast Cancer Therapy.
Tracy-Ann Moo, Rachel Sanford, Chau Dang, Monica Morrow.
PET Clin, 2018 Aug 14; 13(3). PMID: 30100074    Free PMC article.
Review.
Adjuvant Anthracyclines in Breast Cancer: What Is Their Role?
Ami N Shah, William J Gradishar.
Oncologist, 2018 Aug 19; 23(10). PMID: 30120159    Free PMC article.
Review.
A response prediction model for taxane, cisplatin, and 5-fluorouracil chemotherapy in hypopharyngeal carcinoma.
Qi Zhong, Jugao Fang, +10 authors, Yingduan Cheng.
Sci Rep, 2018 Aug 25; 8(1). PMID: 30139993    Free PMC article.
Clinical relevance of the 21-gene Recurrence Score® assay in treatment decisions for patients with node-positive breast cancer in the genomic era.
Eleftherios P Mamounas, Christy A Russell, +2 authors, Kathy S Albain.
NPJ Breast Cancer, 2018 Aug 30; 4. PMID: 30155517    Free PMC article.
Review.
Genomic Testing in the Management of Early-Stage Breast Cancer.
Sima Ehsani, Kari Braun Wisinski.
J Clin Outcomes Manag, 2017 May 01; 24(5). PMID: 30158821    Free PMC article.
RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer-From Cell Line Models to Liquid Biopsies.
Marvin C J Lim, Anne-Marie Baird, +5 authors, Stephen P Finn.
Diagnostics (Basel), 2018 Sep 12; 8(3). PMID: 30200254    Free PMC article.
Review.
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers.
André Filipe Vieira, Fernando Schmitt.
Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119    Free PMC article.
Review.
[Association of circulating tumor cell status with benefit of radiotherapy and survival in early-stage breast cancer].
Marciana Nona Duma.
Strahlenther Onkol, 2018 Sep 22; 194(11). PMID: 30238419
Highlights of the 2015 San Antonio Breast Cancer Symposium.
Mark Keaton, Debu Tripathy, Joyce O'Shaughnessy, Shou-Ching Tang.
Genes Dis, 2016 Mar 25; 3(2). PMID: 30258880    Free PMC article.
Review.
An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA project.
Giacomo Pelizzari, Grazia Arpino, +8 authors, Fabio Puglisi.
BMC Cancer, 2018 Sep 29; 18(1). PMID: 30261866    Free PMC article.
Distribution and Clinical Utility of the 21-gene Recurrence Score in Pure Mucinous Breast Cancer Patients: a case-control study.
Wei Wang, Xiaosong Chen, +12 authors, Kunwei Shen.
J Cancer, 2018 Oct 03; 9(18). PMID: 30271480    Free PMC article.
Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer.
Yesim Gökmen-Polar, Jason D True, +5 authors, Sunil S Badve.
PLoS One, 2018 Oct 03; 13(10). PMID: 30278072    Free PMC article.
Increased derived neutrophil-to-lymphocyte ratio and Breast Imaging-Reporting and Data System classification predict poor survival in patients with non-distant metastatic HER2+ breast cancer treated with neoadjuvant chemotherapy.
Yuyong Li, Yi Shao, Lishan Bai, Xingwei Zhou.
Cancer Manag Res, 2018 Oct 06; 10. PMID: 30288115    Free PMC article.
Novel MicroRNA-Based Risk Score Identified by Integrated Analyses to Predict Metastasis and Poor Prognosis in Breast Cancer.
Tstutomu Kawaguchi, Li Yan, +7 authors, Kazuaki Takabe.
Ann Surg Oncol, 2018 Oct 13; 25(13). PMID: 30311168    Free PMC article.
Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer.
Jiwoong Jung, Young Jin Suh, +5 authors, Ki-Tae Hwang.
Cancer Med, 2018 Oct 13; 7(11). PMID: 30311421    Free PMC article.
Controversial issues in radiotherapy after breast-conserving surgery for early breast cancer in older patients: a systematic review.
Liuwei Tang, Haruo Matsushita, Keiichi Jingu.
J Radiat Res, 2018 Oct 16; 59(6). PMID: 30321392    Free PMC article.
Systematic Review.
The Prognostic Impact of Synchronous Ipsilateral Multiple Breast Cancer: Survival Outcomes according to the Eighth American Joint Committee on Cancer Staging and Molecular Subtype.
Jinah Chu, Hyunsik Bae, +3 authors, Eun Yoon Cho.
J Pathol Transl Med, 2018 Oct 24; 52(6). PMID: 30347971    Free PMC article.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Review.
Combined Performance of Screening and Variable Selection Methods in Ultra-High Dimensional Data in Predicting Time-To-Event Outcomes.
Lira Pi, Susan Halabi.
Diagn Progn Res, 2018 Nov 06; 2. PMID: 30393771    Free PMC article.
Expression of miRNA-206 and miRNA-145 in breast cancer and correlation with prognosis.
Yan Quan, Xianxi Huang, Xiaoxiang Quan.
Oncol Lett, 2018 Nov 09; 16(5). PMID: 30405803    Free PMC article.
Prognostic role of derived neutrophil-to-lymphocyte ratio in surgical triple-negative breast cancer.
Kuojun Ren, Yachao Yin, +2 authors, Shengying Wang.
Cancer Manag Res, 2018 Nov 15; 10. PMID: 30425580    Free PMC article.
Machine Learning With K-Means Dimensional Reduction for Predicting Survival Outcomes in Patients With Breast Cancer.
Melissa Zhao, Yushi Tang, Hyunkyung Kim, Kohei Hasegawa.
Cancer Inform, 2018 Nov 21; 17. PMID: 30455569    Free PMC article.
21-Gene assay as predictor of chemotherapy benefit in HER2-negative breast cancer.
Charles E Geyer, Gong Tang, +8 authors, Norman Wolmark.
NPJ Breast Cancer, 2018 Nov 21; 4. PMID: 30456299    Free PMC article.
BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer.
Mi Jeong Kwon, Sae Byul Lee, +8 authors, Young Kee Shin.
PLoS One, 2018 Nov 22; 13(11). PMID: 30462685    Free PMC article.
Update Breast Cancer 2018 (Part 3) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer.
Achim Wöckel, Michael P Lux, +17 authors, Hans-Christian Kolberg.
Geburtshilfe Frauenheilkd, 2018 Dec 01; 78(11). PMID: 30498278    Free PMC article.
The Warwick Experience of the Oncotype DX® Breast Recurrence Score® Assay as a Predictor of Chemotherapy Administration.
Mashuk Alam Khan, Laura Henderson, +2 authors, Lucie Jones.
Breast Care (Basel), 2018 Dec 01; 13(5). PMID: 30498424    Free PMC article.
Decentralized Learning Framework of Meta-Survival Analysis for Developing Robust Prognostic Signatures.
Yi Cui, Bailiang Li, Ruijiang Li.
JCO Clin Cancer Inform, 2017 Nov 01; 1. PMID: 30657395    Free PMC article.
Adjuvant Systemic Treatment of Premenopausal Women With Hormone Receptor-Positive Early Breast Cancer: Lights and Shadows.
Meredith M Regan, Gini F Fleming, +2 authors, Olivia Pagani.
J Clin Oncol, 2019 Feb 28; 37(11). PMID: 30811287    Free PMC article.
Impact of 21-Gene Recurrence Score on Chemotherapy Decision in Invasive Ductal Carcinoma of Breast with Nodal Micrometastases.
Wei-Rong Chen, Jia-Peng Deng, +3 authors, San-Gang Wu.
Cancer Res Treat, 2019 Mar 28; 51(4). PMID: 30913871    Free PMC article.
Evaluation of the Incorporation of Recurrence Score into the American Joint Committee on Cancer Eighth Edition Staging System in Patients with T1-2N0M0, Estrogen Receptor-Positive, Human Epidermal Growth Receptor 2-Negative Invasive Breast Cancer: A Population-Based Analysis.
Shuning Ding, Jiayi Wu, +6 authors, Li Zhu.
Oncologist, 2019 Apr 26; 24(11). PMID: 31019021    Free PMC article.
Impact of 21-Gene Breast Cancer Assay on Treatment Decision for Patients with T1-T3, N0-N1, Estrogen Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Breast Cancer: Final Results of the Prospective Multicenter ROXANE Study.
Maria Vittoria Dieci, Valentina Guarneri, +16 authors, Veneto Oncology Network.
Oncologist, 2019 Jun 04; 24(11). PMID: 31152079    Free PMC article.
The effect of Oncotype DX® on adjuvant chemotherapy treatment decisions in early breast cancer.
M A Rabie, A Rankin, A Burger, Mmg Youssef.
Ann R Coll Surg Engl, 2019 Jun 21; 101(8). PMID: 31219316    Free PMC article.
Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer.
Mark P Labrecque, Ilsa M Coleman, +19 authors, Colm Morrissey.
J Clin Invest, 2019 Jul 31; 129(10). PMID: 31361600    Free PMC article.
Diffusion-weighted MRI of estrogen receptor-positive, HER2-negative, node-negative breast cancer: association between intratumoral heterogeneity and recurrence risk.
Jin You Kim, Jin Joo Kim, +8 authors, Robert Grimm.
Eur Radiol, 2019 Aug 07; 30(1). PMID: 31385051
Panoptic View of Prognostic Models for Personalized Breast Cancer Management.
Geetanjali Saini, Karuna Mittal, +3 authors, Ritu Aneja.
Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500225    Free PMC article.
Review.
Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial.
Joseph A Sparano, Robert J Gray, +26 authors, George W Sledge.
JAMA Oncol, 2019 Oct 01; 6(3). PMID: 31566680    Free PMC article.
21-Gene recurrence score influences the chemotherapy decision for patients with breast cancer of different luminal subtypes.
Wei Wang, Lin Lin, +11 authors, Kunwei Shen.
Oncol Lett, 2019 Oct 04; 18(4). PMID: 31579428    Free PMC article.
Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26-30.
Seho Park, Yunan Han, +7 authors, Yikyung Park.
Breast Cancer Res, 2019 Oct 18; 21(1). PMID: 31619259    Free PMC article.
Update Breast Cancer 2019 Part 4 - Diagnostic and Therapeutic Challenges of New, Personalised Therapies for Patients with Early Breast Cancer.
Florian Schütz, Peter A Fasching, +16 authors, Volkmar Müller.
Geburtshilfe Frauenheilkd, 2019 Oct 28; 79(10). PMID: 31656318    Free PMC article.
Development and internal validation of a Nomogram for preoperative prediction of surgical treatment effect on cesarean section diverticulum.
Yizhi Wang, Qinyi Zhu, +3 authors, Xipeng Wang.
BMC Womens Health, 2019 Nov 13; 19(1). PMID: 31711470    Free PMC article.
Treatment of Early Breast Cancer Patients: Evidence, Controversies, Consensus: Focusing on Systemic Therapy - German Experts' Opinions for the 16th International St. Gallen Consensus Conference (Vienna 2019).
Diana Lüftner, Ingo Bauerfeind, +21 authors, Marc Thill.
Breast Care (Basel), 2019 Dec 05; 14(5). PMID: 31798392    Free PMC article.
Review.
Decision of Adjuvant Systemic Treatment in HR+ HER2- Early Invasive Breast Cancer: Which Biomarkers Could Help?
Marie Alexandre, Aurélie Maran-Gonzalez, +6 authors, Séverine Guiu.
Cancer Manag Res, 2019 Dec 19; 11. PMID: 31849525    Free PMC article.
Review.
The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer.
Qiancheng Du, Yanyan Wang, +8 authors, Ying Zhou.
Sci Rep, 2019 Dec 20; 9(1). PMID: 31852926    Free PMC article.
Decentralization of Next-Generation RNA Sequencing-Based MammaPrint® and BluePrint® Kit at University Hospitals Leuven and Curie Institute Paris.
Laurence Slembrouck, Lauren Darrigues, +31 authors, Giuseppe Floris.
Transl Oncol, 2019 Sep 13; 12(12). PMID: 31513983    Free PMC article.
RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery.
Nathan D Pennock, Sonali Jindal, +10 authors, Zheng Xia.
BMC Med Genomics, 2019 Dec 21; 12(1). PMID: 31856832    Free PMC article.
A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer.
Vincent T Wu, Boris Kiriazov, +13 authors, Ronald J Weigel.
Mol Cancer Res, 2019 Oct 18; 18(1). PMID: 31619506    Free PMC article.
Omission of Chemotherapy for the Treatment of Mucinous Breast Cancer: A Nationwide Study from the Korean Breast Cancer Society.
Hyung Suk Kim, Jong Uk Lee, +4 authors, Woo Chan Park.
J Breast Cancer, 2020 Jan 04; 22(4). PMID: 31897333    Free PMC article.
Impact of deviation from guideline recommended treatment on breast cancer survival in Asia.
Peh Joo Ho, Samuel Guan Wei Ow, +12 authors, Mikael Hartman.
Sci Rep, 2020 Jan 30; 10(1). PMID: 31992769    Free PMC article.
Evaluation of Prognosis in Hormone Receptor-Positive/HER2-Negative and Lymph Node-Negative Breast Cancer With Low Oncotype DX Recurrence Score.
Jane Meisel, Chao Zhang, +7 authors, Xiaoxian Li.
Clin Breast Cancer, 2018 Jan 07; 18(5). PMID: 29305309    Free PMC article.
Clinicopathologic analysis of 722 breast cancer patients who met the inclusion criteria of the TAILORx trial.
Hong-Yu Xiang, Yin-Hua Liu, +7 authors, Qian Liu.
Chin Med J (Engl), 2019 Dec 07; 132(24). PMID: 31809316    Free PMC article.
Predicting the response to neoadjuvant chemotherapy for breast cancer: wavelet transforming radiomics in MRI.
Jiali Zhou, Jinghui Lu, +5 authors, Maosheng Xu.
BMC Cancer, 2020 Feb 07; 20(1). PMID: 32024483    Free PMC article.
Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers.
Sherene Loi, Damien Drubay, +19 authors, Stefan Michiels.
J Clin Oncol, 2019 Jan 17; 37(7). PMID: 30650045    Free PMC article.
Highly Cited.
Development of an Immune-Related Prognostic Signature in Breast Cancer.
Peiling Xie, Yuying Ma, +3 authors, Huimin Zhang.
Front Genet, 2020 Feb 13; 10. PMID: 32047513    Free PMC article.
Expected Monetary Impact of Oncotype DX Score-Concordant Systemic Breast Cancer Therapy Based on the TAILORx Trial.
Angela Mariotto, Jinani Jayasekerea, +5 authors, Jeanne S Mandelblatt.
J Natl Cancer Inst, 2019 Jun 06; 112(2). PMID: 31165854    Free PMC article.
Comparison of 21-gene assay and St.Gallen International Expert Consensus in the treatment decision for patients with early invasive breast cancers.
Ming Luo, Fu Li, +2 authors, Jian Zeng.
Cancer biology & therapy, 2019 Oct 31; 21(2). PMID: 31663437    Free PMC article.
Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge.
N Engl J Med, 2019 Jun 04; 380(25). PMID: 31157962    Free PMC article.
Highly Cited.
Prognostic Impact of the 21-Gene Recurrence Score Assay Among Young Women With Node-Negative and Node-Positive ER-Positive/HER2-Negative Breast Cancer.
Philip D Poorvu, Shari I Gelber, +12 authors, Ann H Partridge.
J Clin Oncol, 2019 Dec 07; 38(7). PMID: 31809240    Free PMC article.
Adjuvant chemotherapy could not bring survival benefit to HR-positive, HER2-negative, pT1b-c/N0-1/M0 invasive lobular carcinoma of the breast: a propensity score matching study based on SEER database.
Guangfu Hu, Guangxia Hu, +8 authors, Cheng Xu.
BMC Cancer, 2020 Feb 23; 20(1). PMID: 32085753    Free PMC article.
Use and Impact of the 21-Gene Recurrence Score in Relation to the Clinical Risk of Developing Metastases in Early Breast Cancer Patients in the Netherlands.
Kay Schreuder, Anne Kuijer, +2 authors, Sabine Siesling.
Public Health Genomics, 2019 Jan 17; 21(1-2). PMID: 30650410    Free PMC article.
21-Gene Recurrence Score and Adjuvant Chemotherapy Decision for Breast Cancer Patients with Positive Lymph Nodes.
Yiwei Tong, Jiayi Wu, +6 authors, Kunwei Shen.
Sci Rep, 2019 Sep 13; 9(1). PMID: 31511599    Free PMC article.
Racial Differences in 21-Gene Recurrence Scores Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer.
Andreana N Holowatyj, Michele L Cote, +5 authors, Kristen S Purrington.
J Clin Oncol, 2018 Jan 18; 36(7). PMID: 29341832    Free PMC article.
Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer.
Diana C West, Masha Kocherginsky, +20 authors, Suzanne D Conzen.
Clin Cancer Res, 2018 Apr 11; 24(14). PMID: 29636357    Free PMC article.
Simulation Modeling of Cancer Clinical Trials: Application to Omitting Radiotherapy in Low-risk Breast Cancer.
Jinani Jayasekera, Yisheng Li, +21 authors, CISNET-BOLD Collaborative Group.
J Natl Cancer Inst, 2018 May 03; 110(12). PMID: 29718314    Free PMC article.
Correlations between CYP3A4 polymorphism and susceptibility to breast cancer in Chinese Han population.
Xu Liu, Xi Huang, +4 authors, Jikui Liu.
Int J Clin Oncol, 2018 Sep 16; 24(2). PMID: 30218411
Effects of Radiotherapy in Early-Stage, Low-Recurrence Risk, Hormone-Sensitive Breast Cancer.
Jinani Jayasekera, Clyde B Schechter, +17 authors, CISNET-BOLD Collaborative Group.
J Natl Cancer Inst, 2018 Sep 22; 110(12). PMID: 30239794    Free PMC article.
ASO Author Reflections: Biological Diversity of Histologic Subtypes.
Audree B Tadros, Monica Morrow.
Ann Surg Oncol, 2018 Oct 10; 25(Suppl 3). PMID: 30298319    Free PMC article.
Implications for Breast Cancer Restaging Based on the 8th Edition AJCC Staging Manual.
Jennifer K Plichta, Yi Ren, +5 authors, E Shelley Hwang.
Ann Surg, 2018 Oct 13; 271(1). PMID: 30312199    Free PMC article.
Challenging the heterogeneity of disease presentation in malignant melanoma-impact on patient treatment.
A Marcell Szasz, Johan Malm, +5 authors, György Marko-Varga.
Cell Biol Toxicol, 2018 Oct 26; 35(1). PMID: 30357519    Free PMC article.
Review.
Community clinical practice patterns and mortality in patients with intermediate oncotype DX recurrence scores: Who benefits from chemotherapy?
Abiola F Ibraheem, David J Press, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2018 Nov 06; 125(2). PMID: 30387876    Free PMC article.
Introduction of a New Staging System of Breast Cancer for Radiologists: An Emphasis on the Prognostic Stage.
Jieun Koh, Min Jung Kim.
Korean J Radiol, 2019 Jan 11; 20(1). PMID: 30627023    Free PMC article.
Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives.
Andy Dahl, Vincent Guillemot, +2 authors, Noah Zaitlen.
Genetics, 2019 Jan 30; 211(4). PMID: 30692194    Free PMC article.
A novel six-microRNA-based model to improve prognosis prediction of breast cancer.
Jianguo Lai, Hongli Wang, Zihao Pan, Fengxi Su.
Aging (Albany NY), 2019 Jan 31; 11(2). PMID: 30696800    Free PMC article.
Clinical validation of an immunohistochemistry-based CanAssist-Breast test for distant recurrence prediction in hormone receptor-positive breast cancer patients.
Manjiri M Bakre, Charusheila Ramkumar, +10 authors, Mark D Pegram.
Cancer Med, 2019 Mar 09; 8(4). PMID: 30848103    Free PMC article.
Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target.
Pei-Yu Chu, Yu-Ling Tai, Tang-Long Shen.
Cells, 2019 May 15; 8(5). PMID: 31083325    Free PMC article.
Review.
Utility of Ki67 labeling index, cyclin D1 expression, and ER-activity level in postmenopausal ER-positive and HER2-negative breast cancer with neoadjuvant chemo-endocrine therapy.
Sasagu Kurozumi, Yuri Yamaguchi, +6 authors, Kenichi Inoue.
PLoS One, 2019 May 22; 14(5). PMID: 31112577    Free PMC article.
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
A Matikas, T Foukakis, S Swain, J Bergh.
Ann Oncol, 2019 May 28; 30(7). PMID: 31131397    Free PMC article.
Review.
Impact of biomarkers and genetic profiling on breast cancer prognostication: A comparative analysis of the 8th edition of breast cancer staging system.
Esther C Yoon, Christopher Schwartz, +3 authors, Farbod Darvishian.
Breast J, 2019 Jun 15; 25(5). PMID: 31197914    Free PMC article.
Oncotype DX: Where Does It Stand in India?
Atul Batra, Amol Patel, +6 authors, Priyanka Srivastava.
J Glob Oncol, 2019 Jul 17; 5. PMID: 31310569    Free PMC article.
Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer.
Allison W Kurian, Kevin C Ward, +5 authors, Steven J Katz.
JAMA Oncol, 2020 Feb 07; 6(4). PMID: 32027353    Free PMC article.
Development of a four-gene prognostic model for pancreatic cancer based on transcriptome dysregulation.
Jie Yan, Liangcai Wu, +4 authors, Jie Chen.
Aging (Albany NY), 2020 Feb 23; 12(4). PMID: 32081836    Free PMC article.
Lymphedema in survivors of breast cancer.
Lin He, Huili Qu, Qian Wu, Yuhua Song.
Oncol Lett, 2020 Mar 21; 19(3). PMID: 32194706    Free PMC article.
Review.
Association of Diabetes and Other Clinical and Sociodemographic Factors With Guideline-concordant Breast Cancer Treatment for Breast Cancer.
Heather T Gold, Huibo Shao, +4 authors, Denise Boudreau.
Am J Clin Oncol, 2019 Dec 19; 43(2). PMID: 31850918    Free PMC article.
Decision-making of Adjuvant Chemotherapy for Breast Cancer Patients with Discordant Risk Classifications between Clinical-Pathological Factors and 21-gene Recurrence Score.
Weiqi Gao, Lin Lin, +2 authors, Kunwei Shen.
J Cancer, 2020 Mar 24; 11(9). PMID: 32201521    Free PMC article.
Translating RNA sequencing into clinical diagnostics: opportunities and challenges.
Sara A Byron, Kendall R Van Keuren-Jensen, +2 authors, David W Craig.
Nat Rev Genet, 2016 Mar 22; 17(5). PMID: 26996076    Free PMC article.
Highly Cited. Review.
A Radiation Oncologist's Guide to Axillary Management in Breast Cancer: A Walk Through the Trials.
Julie K Jang, Elana R Sverdlik, Naomi R Schechter.
Curr Breast Cancer Rep, 2020 Mar 28; 11(4). PMID: 32215182    Free PMC article.
The impact of Oncotype DX breast cancer assay results on clinical practice: a UK experience.
Valerie E Crolley, Husam Marashi, +12 authors, Judy King.
Breast Cancer Res Treat, 2020 Mar 15; 180(3). PMID: 32170635    Free PMC article.
A benchmark of hemoglobin blocking during library preparation for mRNA-Sequencing of human blood samples.
Florian Uellendahl-Werth, Markus Wolfien, +2 authors, David Ellinghaus.
Sci Rep, 2020 Mar 30; 10(1). PMID: 32221409    Free PMC article.
Adjuvant Therapy Options in Renal Cell Carcinoma: Where Do We Stand?
Nieves Martinez Chanza, Abhishek Tripathi, Lauren C Harshman.
Curr Treat Options Oncol, 2019 May 06; 20(5). PMID: 31054006
Review.
Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer: A Health Technology Assessment.
Ontario Health (Quality).
Ont Health Technol Assess Ser, 2020 Apr 15; 20(10). PMID: 32284770    Free PMC article.
Risk stratification of ER-positive breast cancer patients: A multi-institutional validation and outcome study of the Rochester Modified Magee algorithm (RoMMa) and prediction of an Oncotype DX® recurrence score <26.
Bradley M Turner, Mary Ann Gimenez-Sanders, +6 authors, David G Hicks.
Cancer Med, 2019 Jun 15; 8(9). PMID: 31199586    Free PMC article.
Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT.
Olivia Pagani, Prudence A Francis, +13 authors, SOFT and TEXT Investigators and International Breast Cancer Study Group.
J Clin Oncol, 2019 Oct 17; 38(12). PMID: 31618131    Free PMC article.
Application of magnetic nanoparticles in nucleic acid detection.
Congli Tang, Ziyu He, +10 authors, Nongyue He.
J Nanobiotechnology, 2020 Apr 23; 18(1). PMID: 32316985    Free PMC article.
Review.
One-step colorimetric genotyping of single nucleotide polymorphism using probe-enhanced loop-mediated isothermal amplification (PE-LAMP).
Sheng Ding, Rong Chen, +9 authors, Zhuo Tang.
Theranostics, 2019 Jul 10; 9(13). PMID: 31281509    Free PMC article.
Development and validation of a novel nomogram for pretreatment prediction of liver metastasis in pancreatic cancer.
Shangxiang Chen, Shaojie Chen, +12 authors, Yinting Chen.
Cancer Med, 2020 Feb 29; 9(9). PMID: 32108437    Free PMC article.
Chromatin regulators mediate anthracycline sensitivity in breast cancer.
Jose A Seoane, Jacob G Kirkland, +2 authors, Christina Curtis.
Nat Med, 2019 Nov 09; 25(11). PMID: 31700186    Free PMC article.
A census of pathway maps in cancer systems biology.
Brent M Kuenzi, Trey Ideker.
Nat Rev Cancer, 2020 Feb 19; 20(4). PMID: 32066900    Free PMC article.
Review.
Commercially Available Gene Expression Assays as Predictive Tools for Adjuvant Radiotherapy? A Critical Review.
David Krug, René Baumann, +12 authors, Rolf Sauer.
Breast Care (Basel), 2020 May 14; 15(2). PMID: 32398980    Free PMC article.
Review.
Direct comparison shows that mRNA-based diagnostics incorporate information which cannot be learned directly from genomic mutations.
Hersh D Ravkin, Ofer Givton, David B Geffen, Eitan Rubin.
BMC Bioinformatics, 2020 May 21; 21(1). PMID: 32429832    Free PMC article.
21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort.
J Bryan Iorgulescu, Rachel A Freedman, +2 authors, Jane E Brock.
JCO Precis Oncol, 2019 Jan 01; 3. PMID: 32457931    Free PMC article.
Do 21-Gene Recurrence Score Influence Chemotherapy Decisions in T1bN0 Breast Cancer Patients?
Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen.
Front Oncol, 2020 Jun 02; 10. PMID: 32477946    Free PMC article.
Impact of Recurrence Score on type and duration of chemotherapy in breast cancer.
K Willemsma, W Yip, +5 authors, C E Simmons.
Curr Oncol, 2020 Jun 04; 27(2). PMID: 32489257    Free PMC article.
Patients' perceptions of 70-gene signature testing: commonly changing the initial inclination to undergo or forego chemotherapy and reducing decisional conflict.
Julia E C van Steenhoven, Bianca M den Dekker, +6 authors, Thijs van Dalen.
Breast Cancer Res Treat, 2020 May 21; 182(1). PMID: 32430679    Free PMC article.
EndoPredict® in early hormone receptor-positive, HER2-negative breast cancer.
K Almstedt, S Mendoza, +9 authors, M Schmidt.
Breast Cancer Res Treat, 2020 May 22; 182(1). PMID: 32436145    Free PMC article.
Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer.
Gagan Gupta, Caroline Dasom Lee, +10 authors, Amy H Tang.
Ann Breast Cancer Ther, 2020 Jun 17; 4(1). PMID: 32542231    Free PMC article.
Patient-Reported Cognitive Impairment Among Women With Early Breast Cancer Randomly Assigned to Endocrine Therapy Alone Versus Chemoendocrine Therapy: Results From TAILORx.
Lynne I Wagner, Robert J Gray, +16 authors, David Cella.
J Clin Oncol, 2020 Apr 10; 38(17). PMID: 32271671    Free PMC article.
Neuroendocrine Cancer of the Breast: A Rare Entity.
Azzurra Irelli, Maria Maddalena Sirufo, +3 authors, Massimo De Martinis.
J Clin Med, 2020 May 18; 9(5). PMID: 32414120    Free PMC article.
Review.
RDGN-based predictive model for the prognosis of breast cancer.
Bing Dong, Ming Yi, +2 authors, Kongming Wu.
Exp Hematol Oncol, 2020 Jun 19; 9. PMID: 32550045    Free PMC article.
Shared-patient physician networks and their impact on the uptake of genomic testing in breast cancer.
Jason Rotter, Lauren Wilson, +2 authors, Michaela Dinan.
Breast Cancer Res Treat, 2019 Apr 28; 176(2). PMID: 31028607    Free PMC article.
The concordance of treatment decision guided by OncotypeDX and the PREDICT tool in real-world early-stage breast cancer.
Daniel A Goldstein, Chen Mayer, +5 authors, Hadar Goldvaser.
Cancer Med, 2020 May 07; 9(13). PMID: 32372569    Free PMC article.
Case 22-2020: A 62-Year-Old Woman with Early Breast Cancer during the Covid-19 Pandemic.
Laura M Spring, Michelle C Specht, +6 authors, Beverly Moy.
N Engl J Med, 2020 Jul 02; 383(3). PMID: 32610007    Free PMC article.
Association of Sperm-Associated Antigen 5 and Treatment Response in Patients With Estrogen Receptor-Positive Breast Cancer.
Tarek M A Abdel-Fatah, Graham R Ball, +14 authors, Stephen Y T Chan.
JAMA Netw Open, 2020 Jul 08; 3(7). PMID: 32633764    Free PMC article.
Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction.
David M Kurtz, Mohammad S Esfahani, +20 authors, Ash A Alizadeh.
Cell, 2019 Jul 10; 178(3). PMID: 31280963    Free PMC article.
Sex Disparity Observed for Oncotype DX Breast Recurrence Score in Predicting Mortality Among Patients with Early Stage ER-Positive Breast Cancer.
Fei Wang, Sonya Reid, +6 authors, Xiao-Ou Shu.
Clin Cancer Res, 2019 Nov 22; 26(1). PMID: 31748278    Free PMC article.
Prognostic potential of automated Ki67 evaluation in breast cancer: different hot spot definitions versus true global score.
Stephanie Robertson, Balazs Acs, Michael Lippert, Johan Hartman.
Breast Cancer Res Treat, 2020 Jun 24; 183(1). PMID: 32572716    Free PMC article.
Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation.
Simon J Johnston, Kwok-Leung Cheung.
Oncol Ther, 2018 Dec 01; 6(2). PMID: 32700026    Free PMC article.
Review.
Decision of adjuvant chemotherapy in intermediate risk luminal breast cancer patients: A prospective multicenter trial assessing the clinical and psychological impact of EndoPredict® (EpClin) use (UCBG 2-14).
Frédérique Penault-Llorca, Fabrice Kwiatkowski, +18 authors, Suzette Delaloge.
Breast, 2019 Dec 04; 49. PMID: 31790959    Free PMC article.
Estimation of historical control rate for a single arm de-escalation study - Application to the POSITIVE trial.
Zhuoxin Sun, Samuel M Niman, +9 authors, POSITIVE Steering Committee.
Breast, 2020 Jun 15; 53. PMID: 32535486    Free PMC article.
Clinicopathological characteristics, adjuvant chemotherapy decision and disease outcome in patients with breast cancer with a 21-gene recurrence score of 26-30.
Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724396    Free PMC article.
Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential.
Raza S Hoda, Edi Brogi, +5 authors, Hannah Y Wen.
Histopathology, 2019 Apr 24; 75(2). PMID: 31012486    Free PMC article.
The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database.
In Sil Choi, Jiwoong Jung, +5 authors, Ki-Tae Hwang.
Cancers (Basel), 2020 Jul 12; 12(7). PMID: 32650374    Free PMC article.
Association between the 21-gene recurrence score and isolated locoregional recurrence in stage I-II, hormone receptor-positive breast cancer.
David D Yang, Daniela L Buscariollo, +11 authors, Rinaa S Punglia.
Radiat Oncol, 2020 Aug 18; 15(1). PMID: 32799886    Free PMC article.
Discordance in 21-gene recurrence scores between paired breast cancer samples is inversely associated with patient age.
Sarah M Bernhardt, Pallave Dasari, +6 authors, Wendy V Ingman.
Breast Cancer Res, 2020 Aug 20; 22(1). PMID: 32811558    Free PMC article.
Clinical Utility of Gene Expression Classifiers in Men With Newly Diagnosed Prostate Cancer.
Jonathan C Hu, Jeffrey J Tosoian, +10 authors, Todd M Morgan.
JCO Precis Oncol, 2018 Jan 01; 2. PMID: 32832833    Free PMC article.
Examination of the Biomark assay as an alternative to Oncotype DX for defining chemotherapy benefit.
Jinkyoung Kim, Aeree Kim, Chungyeul Kim.
Oncol Lett, 2019 Jan 25; 17(2). PMID: 30675242    Free PMC article.
Barriers in Latin America for the management of locally advanced breast cancer.
Joseph A Pinto, Luis Pinillos, +13 authors, Carlos S Vallejos.
Ecancermedicalscience, 2019 Feb 23; 13. PMID: 30792814    Free PMC article.
Review.
Neoadjuvant Therapy for Breast Cancer as a Model for Translational Research.
Cigdem Selli, Andrew H Sims.
Breast Cancer (Auckl), 2019 Mar 01; 13. PMID: 30814840    Free PMC article.
Review.
Clinical validation of Ki67 by quantitative reverse transcription-polymerase chain reaction (RT-PCR) in HR+/HER2- early breast cancer.
Weiqi Gao, Jiayi Wu, +4 authors, Ou Huang.
J Cancer, 2019 Mar 12; 10(5). PMID: 30854118    Free PMC article.
Comparison of the 7th and 8th edition of American Joint Committee on Cancer (AJCC) staging systems for breast cancer patients: a Surveillance, Epidemiology and End Results (SEER) Analysis.
Nan Shao, Chuanbo Xie, +6 authors, Ying Lin.
Cancer Manag Res, 2019 Mar 14; 11. PMID: 30863154    Free PMC article.
Initial experience of dedicated breast PET imaging of ER+ breast cancers using [F-18]fluoroestradiol.
Ella F Jones, Kimberly M Ray, +8 authors, Nola M Hylton.
NPJ Breast Cancer, 2019 Apr 25; 5. PMID: 31016232    Free PMC article.
On the use of min-max combination of biomarkers to maximize the partial area under the ROC curve.
Hua Ma, Susan Halabi, Aiyi Liu.
J Probab Stat, 2019 May 07; 2019. PMID: 31057627    Free PMC article.
A Pathology-Based Combined Model to Identify PAM50 Non-luminal Intrinsic Disease in Hormone Receptor-Positive HER2-Negative Breast Cancer.
Tomás Pascual, Miguel Martin, +21 authors, Aleix Prat.
Front Oncol, 2019 May 21; 9. PMID: 31106144    Free PMC article.
Prognostic significance of systemic immune-inflammation index in triple-negative breast cancer.
Jingxin Liu, Zhangzhen Shi, +2 authors, Kailiang Cheng.
Cancer Manag Res, 2019 Jun 14; 11. PMID: 31191009    Free PMC article.
Paradigm Shift From Halstedian Radical Mastectomy to Personalized Medicine.
Vahit Özmen.
J Breast Health, 2017 Apr 01; 13(2). PMID: 31244529    Free PMC article.
Review.
Molecular Decision Tree Algorithms Predict Individual Recurrence Pattern for Locally Advanced Nasopharyngeal Carcinoma.
Hongmin Cai, Xiaolin Pang, +14 authors, Jian Zheng.
J Cancer, 2019 Jul 12; 10(15). PMID: 31293635    Free PMC article.
The Oncotype Dx Assay in ER-Positive, HER2-Negative Breast Cancer Patients: A Real Life Experience from a Single Cancer Center.
Stephane Thibodeau, Ioannis A Voutsadakis.
Eur J Breast Health, 2019 Jul 18; 15(3). PMID: 31312792    Free PMC article.
Gene Expression Assays for Early-Stage Hormone Receptor-Positive Breast Cancer: Understanding the Differences.
Ana Tablante Nunes, Deborah E Collyar, Lyndsay N Harris.
JNCI Cancer Spectr, 2017 Dec 11; 1(1). PMID: 31360834    Free PMC article.
Review.
Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer.
Mi Jeong Kwon, Jeong Eon Lee, +12 authors, Young Kee Shin.
Front Oncol, 2019 Aug 14; 9. PMID: 31404265    Free PMC article.
De-escalation yes, but not at the expense of efficacy: in defense of better treatment.
Charles L Shapiro.
NPJ Breast Cancer, 2019 Aug 21; 5. PMID: 31428678    Free PMC article.
Molecular characterization of breast cancer needle core biopsy specimens by the 21-gene Breast Recurrence Score test.
Debbie M Jakubowski, Helen Bailey, +7 authors, Frederick L Baehner.
J Surg Oncol, 2020 Jun 05;. PMID: 32497318    Free PMC article.
Construction of Nomograms for Predicting Pathological Complete Response and Tumor Shrinkage Size in Breast Cancer.
Shuai Yan, Wenjie Wang, +3 authors, Weiyang Tao.
Cancer Manag Res, 2020 Sep 29; 12. PMID: 32982426    Free PMC article.
Genomic Signatures in Luminal Breast Cancer.
Julian Puppe, Tabea Seifert, +3 authors, Wolfram Malter.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982645    Free PMC article.
Review.
Future perspectives of surgical treatment of breast cancer.
Margit Riis.
Ann Med Surg (Lond), 2020 Oct 03; 59. PMID: 33005399    Free PMC article.
Assessment of tumour proliferation by use of the mitotic activity index, and Ki67 and phosphohistone H3 expression, in early-stage luminal breast cancer.
Julia E C van Steenhoven, Anne Kuijer, +4 authors, Paul J van Diest.
Histopathology, 2020 Jun 20; 77(4). PMID: 32557844    Free PMC article.
Gene Expression Profiling Identifies Akt as a Target for Radiosensitization in Gastric Cancer Cells.
Kyung Hwan Kim, Han Sang Kim, +4 authors, Sun Young Rha.
Front Oncol, 2020 Oct 13; 10. PMID: 33042843    Free PMC article.
Clinical utility of genomic signatures in young breast cancer patients: a systematic review.
Cynthia Villarreal-Garza, Ana S Ferrigno, +3 authors, Hatem A Azim.
NPJ Breast Cancer, 2020 Oct 17; 6. PMID: 33062888    Free PMC article.
Review.
Survey of Radiation Oncologists to Assess Interest and Potential Use of a Genetic Test Predicting Susceptibility for the Development of Toxicities After Prostate Cancer Radiation Therapy.
Kayla Collado, Sarah L Kerns, +7 authors, Barry S Rosenstein.
Adv Radiat Oncol, 2020 Oct 22; 5(5). PMID: 33083651    Free PMC article.
Beyond Chemotherapies: Recent Strategies in Breast Cancer Treatment.
Arthur Foulon, Pierrick Theret, Lise Rodat-Despoix, Philippe Kischel.
Cancers (Basel), 2020 Sep 20; 12(9). PMID: 32947780    Free PMC article.
Review.
Circulating MicroRNAs as Prognostic and Therapeutic Biomarkers in Breast Cancer Molecular Subtypes.
Veronica Zelli, Chiara Compagnoni, +7 authors, Edoardo Alesse.
J Pers Med, 2020 Aug 28; 10(3). PMID: 32842653    Free PMC article.
Review.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
Racial and ethnic disparities in 21-gene recurrence scores, chemotherapy, and survival among women with hormone receptor-positive, node-negative breast cancer.
Yunan Han, Zhi-Feng Miao, +3 authors, Ying Liu.
Breast Cancer Res Treat, 2020 Sep 16; 184(3). PMID: 32929567    Free PMC article.
Update Breast Cancer 2020 Part 3 - Early Breast Cancer.
Jens Huober, Andreas Schneeweiss, +16 authors, Achim Wöckel.
Geburtshilfe Frauenheilkd, 2020 Nov 12; 80(11). PMID: 33173238    Free PMC article.
Oncotype DX Breast Recurrence Score Distribution and Chemotherapy Benefit Among Women of Different Age Groups With HR-Positive, HER2-Negative, Node-Negative Breast Cancer in the SEER Database.
Ran Cheng, Xiangyi Kong, +2 authors, Jing Wang.
Front Oncol, 2020 Nov 17; 10. PMID: 33194568    Free PMC article.
Individualized Prediction of Survival by a 10-Long Non-coding RNA-Based Prognostic Model for Patients With Breast Cancer.
Xuemei Yang, Juan Li, +9 authors, Chuanxin Wang.
Front Oncol, 2020 Nov 17; 10. PMID: 33194577    Free PMC article.
How to Predict Metastasis in Luminal Breast Cancer? Current Solutions and Future Prospects.
Sylwia Tabor, Małgorzata Szostakowska-Rodzos, Anna Fabisiewicz, Ewa A Grzybowska.
Int J Mol Sci, 2020 Nov 14; 21(21). PMID: 33182512    Free PMC article.
Review.