. 2015 Nov; 36(12):822-846.
doi: 10.1016/

Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

Murugan Kalimutho 1 Kate Parsons 2 Deepak Mittal 3 J Alejandro López 4 Sriganesh Srihari 5 Kum Kum Khanna 6 
  • PMID: 26538316
  •     95 citations


Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast cancers that have a poor clinical outcome. Although no approved targeted therapy is available for TNBCs, molecular-profiling efforts have revealed promising molecular targets, with several candidate compounds having now entered clinical trials for TNBC patients. However, initial results remain modest, thereby highlighting challenges potentially involving intra- and intertumoral heterogeneity and acquisition of therapy resistance. We present a comprehensive review on emerging targeted therapies for treating TNBCs, including the promising approach of immunotherapy and the prognostic value of tumor-infiltrating lymphocytes. We discuss the impact of pathway rewiring in the acquisition of drug resistance, and the prospect of employing combination therapy strategies to overcome challenges towards identifying clinically-viable targeted treatment options for TNBC.

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