Review
. 2015 Dec;13(4).
doi: 10.1038/nrclinonc.2015.215.

Clinical relevance of host immunity in breast cancer: from TILs to the clinic

Peter Savas 1 Roberto Salgado 2 Carsten Denkert 3 Christos Sotiriou 2 Phillip K Darcy 1 Mark J Smyth 4 Sherene Loi 1 
Affiliations
  • PMID: 26667975
  •     117 References
  •     150 citations

Abstract

The clinical relevance of the host immune system in breast cancer has long been unexplored. Studies developed over the past decade have highlighted the biological heterogeneity of breast cancer, prompting researchers to investigate whether the role of the immune system in this malignancy is similar across different molecular subtypes of the disease. The presence of high levels of lymphocytic infiltration has been consistently associated with a more-favourable prognosis in patients with early stage triple-negative and HER2-positive breast cancer. These infiltrates seem to reflect favourable host antitumour immune responses, suggesting that immune activation is important for improving survival outcomes. In this Review, we discuss the composition of the immune infiltrates observed in breast cancers, as well as data supporting the clinical relevance of host antitumour immunity, as represented by lymphocytic infiltration, and how this biomarker could be used in the clinical setting. We also discuss the rationale for enhancing immunity in breast cancer, including early data on the efficacy of T-cell checkpoint inhibition in this setting.

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.
Laurent Monney, Catherine A Sabatos, +9 authors, Vijay K Kuchroo.
Nature, 2002 Feb 02; 415(6871). PMID: 11823861
Highly Cited.
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
Roy S Herbst, Jean-Charles Soria, +19 authors, F Stephen Hodi.
Nature, 2014 Nov 28; 515(7528). PMID: 25428504    Free PMC article.
Highly Cited.
Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies.
Inge Verbrugge, Jim Hagekyriakou, +8 authors, Nicole M Haynes.
Cancer Res, 2012 May 10; 72(13). PMID: 22570253
Highly Cited.
Nivolumab plus ipilimumab in advanced melanoma.
Jedd D Wolchok, Harriet Kluger, +21 authors, Mario Sznol.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724867    Free PMC article.
Highly Cited.
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Yu-Hwa Huang, Chen Zhu, +21 authors, Richard S Blumberg.
Nature, 2014 Nov 05; 517(7534). PMID: 25363763    Free PMC article.
Highly Cited.
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.
R Salgado, C Denkert, +30 authors, International TILs Working Group 2014.
Ann Oncol, 2014 Sep 13; 26(2). PMID: 25214542    Free PMC article.
Highly Cited.
Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses.
I Gramaglia, A D Weinberg, M Lemon, M Croft.
J Immunol, 1998 Dec 23; 161(12). PMID: 9862675
Highly Cited.
Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients.
H R Ali, E Provenzano, +18 authors, C Caldas.
Ann Oncol, 2014 Jun 12; 25(8). PMID: 24915873
Highly Cited.
CD4+ T lymphocytes infiltrating human breast cancer recognise autologous tumor in an MHC-class-II restricted fashion.
R Dadmarz, M K Sgagias, S A Rosenberg, D J Schwartzentruber.
Cancer Immunol Immunother, 1995 Jan 01; 40(1). PMID: 7828162
T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion.
Julia M Marchingo, Andrey Kan, +7 authors, Philip D Hodgkin.
Science, 2014 Nov 29; 346(6213). PMID: 25430770
Highly Cited.
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
François Ghiringhelli, Lionel Apetoh, +23 authors, Laurence Zitvogel.
Nat Med, 2009 Sep 22; 15(10). PMID: 19767732
Highly Cited.
OX40 costimulation turns off Foxp3+ Tregs.
Minh Diem Vu, Xiang Xiao, +6 authors, Xian Chang Li.
Blood, 2007 Jun 19; 110(7). PMID: 17575071    Free PMC article.
Highly Cited.
Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.
Osamu Kawai, Genichiro Ishii, +9 authors, Atsushi Ochiai.
Cancer, 2008 Aug 02; 113(6). PMID: 18671239
Highly Cited.
Immune cell quantitation in normal breast tissue lobules with and without lobulitis.
Amy C Degnim, Rushin D Brahmbhatt, +8 authors, Daniel W Visscher.
Breast Cancer Res Treat, 2014 Mar 07; 144(3). PMID: 24596048    Free PMC article.
Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy.
John Stagg, Sherene Loi, +5 authors, Mark J Smyth.
Proc Natl Acad Sci U S A, 2011 Apr 13; 108(17). PMID: 21482773    Free PMC article.
Highly Cited.
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Lionel Apetoh, François Ghiringhelli, +25 authors, Laurence Zitvogel.
Nat Med, 2007 Aug 21; 13(9). PMID: 17704786
Highly Cited.
Postnatal mammary gland development requires macrophages and eosinophils.
V Gouon-Evans, M E Rothenberg, J W Pollard.
Development, 2000 May 11; 127(11). PMID: 10804170
Highly Cited.
New insights into the development of lymphoid tissues.
Serge A van de Pavert, Reina E Mebius.
Nat Rev Immunol, 2010 Aug 14; 10(9). PMID: 20706277
Highly Cited. Review.
PD-1 blockade induces responses by inhibiting adaptive immune resistance.
Paul C Tumeh, Christina L Harview, +23 authors, Antoni Ribas.
Nature, 2014 Nov 28; 515(7528). PMID: 25428505    Free PMC article.
Highly Cited.
LIFE EXPECTANCY FOLLOWING RADICAL AMPUTATION FOR CARCINOMA OF THE BREAST: A CLINICAL AND PATHOLOGIC STUDY OF 218 CASES.
W E Sistrunk, W C Maccarty.
Ann Surg, 1922 Jan 01; 75(1). PMID: 17864583    Free PMC article.
Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial.
Robert A Hauser, C Warren Olanow, +9 authors, Stephen Bandak.
Lancet Neurol, 2014 Jul 11; 13(8). PMID: 25008546
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.
Naiyer A Rizvi, Matthew D Hellmann, +21 authors, Timothy A Chan.
Science, 2015 Mar 15; 348(6230). PMID: 25765070    Free PMC article.
Highly Cited.
Phenotypic analysis of tumor-infiltrating lymphocytes from human breast cancer.
Y Chin, J Janseens, +3 authors, J Raus.
Anticancer Res, 1992 Sep 01; 12(5). PMID: 1332579
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.
Eric Tran, Simon Turcotte, +10 authors, Steven A Rosenberg.
Science, 2014 May 09; 344(6184). PMID: 24812403    Free PMC article.
Highly Cited.
Immunological aspects of cancer chemotherapy.
Laurence Zitvogel, Lionel Apetoh, François Ghiringhelli, Guido Kroemer.
Nat Rev Immunol, 2007 Dec 22; 8(1). PMID: 18097448
Highly Cited. Review.
ER, PgR, Ki67, p27(Kip1), and histological grade as predictors of pathological complete response in patients with HER2-positive breast cancer receiving neoadjuvant chemotherapy using taxanes followed by fluorouracil, epirubicin, and cyclophosphamide concomitant with trastuzumab.
Sasagu Kurozumi, Kenichi Inoue, +5 authors, Tetsunari Oyama.
BMC Cancer, 2015 Sep 09; 15. PMID: 26345461    Free PMC article.
Clonal evolution in breast cancer revealed by single nucleus genome sequencing.
Yong Wang, Jill Waters, +13 authors, Nicholas E Navin.
Nature, 2014 Aug 01; 512(7513). PMID: 25079324    Free PMC article.
Highly Cited.
Characterization of lymphocytes infiltrating human breast cancer: specific immune reactivity detected by measuring cytokine secretion.
D J Schwartzentruber, D Solomon, S A Rosenberg, S L Topalian.
J Immunother (1991), 1992 Jul 01; 12(1). PMID: 1637779
Prospective validation of immunological infiltrate for prediction of response to neoadjuvant chemotherapy in HER2-negative breast cancer--a substudy of the neoadjuvant GeparQuinto trial.
Yasmin Issa-Nummer, Silvia Darb-Esfahani, +18 authors, Carsten Denkert.
PLoS One, 2013 Dec 07; 8(12). PMID: 24312450    Free PMC article.
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.
S Read, V Malmström, F Powrie.
J Exp Med, 2000 Jul 19; 192(2). PMID: 10899916    Free PMC article.
Highly Cited.
Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: a pooled analysis.
Michail Ignatiadis, Sandeep K Singhal, +7 authors, Christos Sotiriou.
J Clin Oncol, 2012 Apr 18; 30(16). PMID: 22508827
Highly Cited.
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
M F Krummel, J P Allison.
J Exp Med, 1995 Aug 01; 182(2). PMID: 7543139    Free PMC article.
Highly Cited.
Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria.
Jedd D Wolchok, Axel Hoos, +9 authors, F Stephen Hodi.
Clin Cancer Res, 2009 Nov 26; 15(23). PMID: 19934295
Highly Cited.
Beyond immune density: critical role of spatial heterogeneity in estrogen receptor-negative breast cancer.
Sidra Nawaz, Andreas Heindl, Konrad Koelble, Yinyin Yuan.
Mod Pathol, 2015 Feb 28; 28(6). PMID: 25720324
Specific recruitment of γδ regulatory T cells in human breast cancer.
Jian Ye, Chunling Ma, +9 authors, Guangyong Peng.
Cancer Res, 2013 Aug 21; 73(20). PMID: 23959855    Free PMC article.
Calreticulin exposure dictates the immunogenicity of cancer cell death.
Michel Obeid, Antoine Tesniere, +14 authors, Guido Kroemer.
Nat Med, 2006 Dec 26; 13(1). PMID: 17187072
Highly Cited.
Predictors of complete pathological response after neoadjuvant systemic therapy for breast cancer.
Marcus C Tan, Fatema Al Mushawah, +4 authors, Julie A Margenthaler.
Am J Surg, 2009 Oct 06; 198(4). PMID: 19800460    Free PMC article.
Type I interferon is selectively required by dendritic cells for immune rejection of tumors.
Mark S Diamond, Michelle Kinder, +9 authors, Robert D Schreiber.
J Exp Med, 2011 Sep 21; 208(10). PMID: 21930769    Free PMC article.
Highly Cited.
Predictors of pathologic complete response after standard neoadjuvant chemotherapy in triple-negative breast carcinoma.
James A Kraus, Sushil Beriwal, +6 authors, Rohit Bhargava.
Appl Immunohistochem Mol Morphol, 2012 Mar 16; 20(4). PMID: 22417856
The future of immune checkpoint therapy.
Padmanee Sharma, James P Allison.
Science, 2015 Apr 04; 348(6230). PMID: 25838373
Highly Cited. Review.
Host antitumor immunity plays a role in the survival of patients with newly diagnosed triple-negative breast cancer.
Sherene Loi.
J Clin Oncol, 2014 Jul 30; 32(27). PMID: 25071115
Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer.
Nathan R West, Katy Milne, +3 authors, Peter H Watson.
Breast Cancer Res, 2011 Dec 14; 13(6). PMID: 22151962    Free PMC article.
Highly Cited.
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.
Robert D Schreiber, Lloyd J Old, Mark J Smyth.
Science, 2011 Mar 26; 331(6024). PMID: 21436444
Highly Cited. Review.
Flow cytometric analysis of tumour infiltrating lymphocyte activation and tumour cell MHC class I and II expression in breast cancer patients.
P Whitford, W D George, A M Campbell.
Cancer Lett, 1992 Jan 10; 61(2). PMID: 1730139
Use of archived specimens in evaluation of prognostic and predictive biomarkers.
Richard M Simon, Soonmyung Paik, Daniel F Hayes.
J Natl Cancer Inst, 2009 Oct 10; 101(21). PMID: 19815849    Free PMC article.
Highly Cited.
Enhancement of antitumor immunity by CTLA-4 blockade.
D R Leach, M F Krummel, J P Allison.
Science, 1996 Mar 22; 271(5256). PMID: 8596936
Highly Cited.
Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial.
Roberto Salgado, Carsten Denkert, +13 authors, Sherene Loi.
JAMA Oncol, 2015 Jul 17; 1(4). PMID: 26181252    Free PMC article.
Highly Cited.
CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer.
Sherene Loi, Sandra Pommey, +4 authors, John Stagg.
Proc Natl Acad Sci U S A, 2013 Jun 19; 110(27). PMID: 23776241    Free PMC article.
Highly Cited.
Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors.
Shin Foong Ngiow, Bianca von Scheidt, +3 authors, Mark J Smyth.
Cancer Res, 2011 Mar 25; 71(10). PMID: 21430066
Highly Cited.
Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis.
Edward C Stack, Chichung Wang, Kristin A Roman, Clifford C Hoyt.
Methods, 2014 Sep 23; 70(1). PMID: 25242720
Highly Cited. Review.
Clonal expansion of T cells: a cytotoxic T-cell response in vivo that involves precursor cell proliferation.
F Denizot, A Wilson, +2 authors, K Shortman.
Proc Natl Acad Sci U S A, 1986 Aug 01; 83(16). PMID: 3090549    Free PMC article.
Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients.
Bernhard Mlecnik, Gabriela Bindea, +15 authors, Jérôme Galon.
Sci Transl Med, 2014 Mar 22; 6(228). PMID: 24648340
Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis.
Patricia Cortazar, Lijun Zhang, +34 authors, Gunter von Minckwitz.
Lancet, 2014 Feb 18; 384(9938). PMID: 24529560
Highly Cited. Review.
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity.
Kaori Sakuishi, Lionel Apetoh, +3 authors, Ana C Anderson.
J Exp Med, 2010 Sep 08; 207(10). PMID: 20819927    Free PMC article.
Highly Cited.
Tumor specific cytolysis by tumor infiltrating lymphocytes in breast cancer.
C N Baxevanis, G V Dedoussis, +3 authors, M Papamichail.
Cancer, 1994 Aug 15; 74(4). PMID: 7914469
An international Ki67 reproducibility study.
Mei-Yin C Polley, Samuel C Y Leung, +16 authors, International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group.
J Natl Cancer Inst, 2013 Nov 10; 105(24). PMID: 24203987    Free PMC article.
Highly Cited.
Ultrastructure of IL2-stimulated tumor-infiltrating lymphocytes showing cytolytic activity against tumor cells.
H Tanaka, M Watanabe, M Zeniya, H Takahashi.
Acta Pathol Jpn, 1991 Feb 01; 41(2). PMID: 1710414
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors.
Paul A Beavis, Upulie Divisekera, +7 authors, Phillip K Darcy.
Proc Natl Acad Sci U S A, 2013 Aug 22; 110(36). PMID: 23964122    Free PMC article.
Highly Cited.
Improved survival with ipilimumab in patients with metastatic melanoma.
F Stephen Hodi, Steven J O'Day, +26 authors, Walter J Urba.
N Engl J Med, 2010 Jun 08; 363(8). PMID: 20525992    Free PMC article.
Highly Cited.
Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right.
Carl E Ruby, Melissa A Yates, +5 authors, Andrew D Weinberg.
J Immunol, 2009 Sep 30; 183(8). PMID: 19786544    Free PMC article.
Molecular and genetic properties of tumors associated with local immune cytolytic activity.
Michael S Rooney, Sachet A Shukla, +2 authors, Nir Hacohen.
Cell, 2015 Jan 17; 160(1-2). PMID: 25594174    Free PMC article.
Highly Cited.
The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer.
C Horlock, B Stott, +4 authors, J Stebbing.
Br J Cancer, 2009 Mar 12; 100(7). PMID: 19277040    Free PMC article.
Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer.
Elena García-Martínez, Ginés Luengo Gil, +6 authors, Francisco Ayala de la Peña.
Breast Cancer Res, 2014 Nov 30; 16(6). PMID: 25432519    Free PMC article.
Highly Cited.
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.
Carsten Linnemann, Marit M van Buuren, +13 authors, Ton N M Schumacher.
Nat Med, 2014 Dec 23; 21(1). PMID: 25531942
Highly Cited.
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.
Sergio A Quezada, Karl S Peggs, +3 authors, James P Allison.
J Exp Med, 2008 Aug 30; 205(9). PMID: 18725522    Free PMC article.
Highly Cited.
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.
Paul F Robbins, Yong-Chen Lu, +9 authors, Steven A Rosenberg.
Nat Med, 2013 May 07; 19(6). PMID: 23644516    Free PMC article.
Highly Cited.
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.
Mohini Rajasagi, Sachet A Shukla, +16 authors, Catherine J Wu.
Blood, 2014 Jun 04; 124(3). PMID: 24891321    Free PMC article.
Highly Cited.
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer.
Rajeev K Shrimali, Zhiya Yu, +3 authors, Steven A Rosenberg.
Cancer Res, 2010 Jul 16; 70(15). PMID: 20631075    Free PMC article.
Highly Cited.
Nivolumab in previously untreated melanoma without BRAF mutation.
Caroline Robert, Georgina V Long, +25 authors, Paolo A Ascierto.
N Engl J Med, 2014 Nov 18; 372(4). PMID: 25399552
Highly Cited.
Immunity, inflammation and cancer: a leading role for adenosine.
Luca Antonioli, Corrado Blandizzi, Pál Pacher, György Haskó.
Nat Rev Cancer, 2013 Nov 15; 13(12). PMID: 24226193
Highly Cited. Review.
Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors.
Stephen R Mattarollo, Sherene Loi, +3 authors, Mark J Smyth.
Cancer Res, 2011 Jun 08; 71(14). PMID: 21646474
Highly Cited.
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.
Mahesh Yadav, Suchit Jhunjhunwala, +11 authors, Lélia Delamarre.
Nature, 2014 Nov 28; 515(7528). PMID: 25428506
Highly Cited.
In situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas.
Kurt A Schalper, Vamsidhar Velcheti, +4 authors, David L Rimm.
Clin Cancer Res, 2014 Mar 22; 20(10). PMID: 24647569
Highly Cited.
Clonal expansion of human T lymphocytes initiated by dendritic cells.
E Langhoff, R M Steinman.
J Exp Med, 1989 Jan 01; 169(1). PMID: 2562849    Free PMC article.
T cell exclusion, immune privilege, and the tumor microenvironment.
Johanna A Joyce, Douglas T Fearon.
Science, 2015 Apr 04; 348(6230). PMID: 25838376
Highly Cited. Review.
Tumor-infiltrating lymphocytes are important pathologic predictors for neoadjuvant chemotherapy in patients with breast cancer.
Rin Yamaguchi, Maki Tanaka, +9 authors, Hirohisa Yano.
Hum Pathol, 2012 Apr 21; 43(10). PMID: 22516244
RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors.
Sherene Loi, Sathana Dushyanthen, +22 authors, Justin M Balko.
Clin Cancer Res, 2015 Oct 31; 22(6). PMID: 26515496    Free PMC article.
Highly Cited.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski.
Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400    Free PMC article.
Highly Cited.
Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy.
S Demaria, M D Volm, +5 authors, W F Symmans.
Clin Cancer Res, 2001 Oct 12; 7(10). PMID: 11595690
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.
Alena Gros, Paul F Robbins, +13 authors, Steven A Rosenberg.
J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667641    Free PMC article.
Highly Cited.
Flow cytometry: principles and clinical applications in hematology.
M Brown, C Wittwer.
Clin Chem, 2000 Aug 06; 46(8 Pt 2). PMID: 10926916
Review.
A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors.
Marcus Schmidt, Birte Hellwig, +33 authors, Jan G Hengstler.
Clin Cancer Res, 2012 Feb 22; 18(9). PMID: 22351685
Highly Cited.
Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells.
Sylvain Ladoire, Laurent Arnould, +5 authors, François Ghiringhelli.
Clin Cancer Res, 2008 Apr 17; 14(8). PMID: 18413832
TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer.
Kaori Sakuishi, Shin Foong Ngiow, +4 authors, Ana C Anderson.
Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734331    Free PMC article.
Highly Cited.
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody.
M Zahidunnabi Dewan, Ashley E Galloway, +4 authors, Sandra Demaria.
Clin Cancer Res, 2009 Aug 27; 15(17). PMID: 19706802    Free PMC article.
Highly Cited.
Leukocyte composition of human breast cancer.
Brian Ruffell, Alfred Au, +3 authors, Lisa M Coussens.
Proc Natl Acad Sci U S A, 2011 Aug 10; 109(8). PMID: 21825174    Free PMC article.
Highly Cited.
Comprehensive molecular portraits of human breast tumours.
Cancer Genome Atlas Network.
Nature, 2012 Sep 25; 490(7418). PMID: 23000897    Free PMC article.
Highly Cited.
Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodies.
Edouard Tuaillon, Diane Valea, +5 authors, Jean-Pierre Vendrell.
J Immunol, 2009 May 21; 182(11). PMID: 19454712
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Christina Twyman-Saint Victor, Andrew J Rech, +22 authors, Andy J Minn.
Nature, 2015 Mar 11; 520(7547). PMID: 25754329    Free PMC article.
Highly Cited.
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer.
Carsten Denkert, Sibylle Loibl, +14 authors, Gunter von Minckwitz.
J Clin Oncol, 2009 Nov 18; 28(1). PMID: 19917869
Highly Cited.
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis.
John Stagg, Upulie Divisekera, +5 authors, Mark J Smyth.
Proc Natl Acad Sci U S A, 2010 Jan 19; 107(4). PMID: 20080644    Free PMC article.
Highly Cited.
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
Gregory T Motz, Stephen P Santoro, +7 authors, George Coukos.
Nat Med, 2014 May 06; 20(6). PMID: 24793239    Free PMC article.
Highly Cited.
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Seng-Ryong Woo, Mercedes B Fuertes, +9 authors, Thomas F Gajewski.
Immunity, 2014 Dec 18; 41(5). PMID: 25517615    Free PMC article.
Highly Cited.
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.
Eliezer M Van Allen, Diana Miao, +19 authors, Levi A Garraway.
Science, 2015 Sep 12; 350(6257). PMID: 26359337    Free PMC article.
Highly Cited.
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival.
Chunyan Gu-Trantien, Sherene Loi, +21 authors, Karen Willard-Gallo.
J Clin Invest, 2013 Jun 20; 123(7). PMID: 23778140    Free PMC article.
Highly Cited.
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial.
S Loi, S Michiels, +13 authors, C Sotiriou.
Ann Oncol, 2014 Mar 13; 25(8). PMID: 24608200
Highly Cited.
Metastatic triple-negative breast cancers at first relapse have fewer tumor-infiltrating lymphocytes than their matched primary breast tumors: a pilot study.
Ashley Cimino-Mathews, Xiaobu Ye, +2 authors, Leisha A Emens.
Hum Pathol, 2013 May 25; 44(10). PMID: 23701942    Free PMC article.
Programmed death ligand-1 expression in non-small cell lung cancer.
Vamsidhar Velcheti, Kurt A Schalper, +7 authors, David L Rimm.
Lab Invest, 2013 Nov 13; 94(1). PMID: 24217091    Free PMC article.
Highly Cited.
Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses.
Andrew L Mellor, Derin B Keskin, +2 authors, David H Munn.
J Immunol, 2002 Apr 09; 168(8). PMID: 11937528
T-lymphocyte subsets in primary lung cancer.
I Tsuyuguchi, H Shiratsuchi, M Fukuoka.
Jpn J Clin Oncol, 1987 Mar 01; 17(1). PMID: 3494139
Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98.
Sherene Loi, Nicolas Sirtaine, +13 authors, Christos Sotiriou.
J Clin Oncol, 2013 Jan 24; 31(7). PMID: 23341518
Highly Cited.
Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and IFN-gamma by human tumor-infiltrating lymphocytes after autologous tumor stimulation.
D J Schwartzentruber, S L Topalian, M Mancini, S A Rosenberg.
J Immunol, 1991 May 15; 146(10). PMID: 1902860
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
Mercedes B Fuertes, Aalok K Kacha, +4 authors, Thomas F Gajewski.
J Exp Med, 2011 Sep 21; 208(10). PMID: 21930765    Free PMC article.
Highly Cited.
Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.
Sylvia Adams, Robert J Gray, +13 authors, Sunil S Badve.
J Clin Oncol, 2014 Jul 30; 32(27). PMID: 25071121    Free PMC article.
Highly Cited.
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer.
Feng Qian, Jeannine Villella, +15 authors, Kunle Odunsi.
Cancer Res, 2009 Jun 06; 69(13). PMID: 19491279
Lymphoreticular infiltration in human tumours: prognostic and biological implications: a review.
J C Underwood.
Br J Cancer, 1974 Dec 01; 30(6). PMID: 4614858    Free PMC article.
Highly Cited. Review.
Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells.
Robert H Vonderheide, Patricia M LoRusso, +9 authors, Susan M Domchek.
Clin Cancer Res, 2010 May 19; 16(13). PMID: 20479064
Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: a role for hematopoietic growth factor release by tumor cells?
R P Tang, B Kacinski, +7 authors, S Scholl.
J Cell Biochem, 1990 Nov 01; 44(3). PMID: 1980125
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Haidong Dong, Scott E Strome, +10 authors, Lieping Chen.
Nat Med, 2002 Jul 02; 8(8). PMID: 12091876
Highly Cited.
Immune Checkpoint Blockade in Cancer Therapy.
Michael A Postow, Margaret K Callahan, Jedd D Wolchok.
J Clin Oncol, 2015 Jan 22; 33(17). PMID: 25605845    Free PMC article.
Highly Cited. Review.
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
Carsten Denkert, Gunter von Minckwitz, +27 authors, Sibylle Loibl.
J Clin Oncol, 2014 Dec 24; 33(9). PMID: 25534375
Highly Cited.
Prognostic value of tumor-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: a retrospective multicenter study.
M V Dieci, C Criscitiello, +8 authors, F Andre.
Ann Oncol, 2014 Jan 10; 25(3). PMID: 24401929    Free PMC article.
Highly Cited.
Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses.
Paul A Beavis, Nicole Milenkovski, +6 authors, Phillip K Darcy.
Cancer Immunol Res, 2015 Feb 13; 3(5). PMID: 25672397
Highly Cited.
Translocation of an intracellular antigen to the surface of medullary breast cancer cells early in apoptosis allows for an antigen-driven antibody response elicited by tumor-infiltrating B cells.
Margit H Hansen, Heidi V Nielsen, Henrik J Ditzel.
J Immunol, 2002 Aug 24; 169(5). PMID: 12193744
Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.
Diana Paola Granados, Dev Sriranganadane, +10 authors, Claude Perreault.
Nat Commun, 2014 Apr 10; 5. PMID: 24714562    Free PMC article.
OX40 is a potent immune-stimulating target in late-stage cancer patients.
Brendan D Curti, Magdalena Kovacsovics-Bankowski, +20 authors, Andrew D Weinberg.
Cancer Res, 2013 Nov 02; 73(24). PMID: 24177180    Free PMC article.
Highly Cited.
Ki-67 expression in luminal type breast cancer and its association with the clinicopathology of the cancer.
Peng Yuan, Benling Xu, +3 authors, Long Yuan.
Oncol Lett, 2016 Mar 22; 11(3). PMID: 26998129    Free PMC article.
Translating neoadjuvant therapy into survival benefits: one size does not fit all.
Leticia De Mattos-Arruda, Ronglai Shen, Jorge S Reis-Filho, Javier Cortés.
Nat Rev Clin Oncol, 2016 Mar 24; 13(9). PMID: 27000962    Free PMC article.
Review.
Tumor-Infiltrating Lymphocytes in Triple Negative Breast Cancer: The Future of Immune Targeting.
Paula García-Teijido, María Luque Cabal, Ignacio Peláez Fernández, Yolanda Fernández Pérez.
Clin Med Insights Oncol, 2016 Apr 16; 10(Suppl 1). PMID: 27081325    Free PMC article.
Highly Cited. Review.
Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases.
Olga Aprelikova, Christine C Tomlinson, +8 authors, Jeffrey E Green.
PLoS One, 2016 May 14; 11(5). PMID: 27171183    Free PMC article.
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.
Giampaolo Bianchini, Justin M Balko, +2 authors, Luca Gianni.
Nat Rev Clin Oncol, 2016 Oct 19; 13(11). PMID: 27184417    Free PMC article.
Highly Cited. Review.
Immunological Mechanisms in Breast Cancer - from Bench to Bedside.
Carsten Denkert, Florian Schütz.
Breast Care (Basel), 2016 May 31; 11(2). PMID: 27239169    Free PMC article.
Checkpoint Inhibitors and Their Application in Breast Cancer.
Davide Bedognetti, Cristina Maccalli, +2 authors, Barbara Seliger.
Breast Care (Basel), 2016 May 31; 11(2). PMID: 27239172    Free PMC article.
Review.
Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes.
Sasagu Kurozumi, Yuri Yamaguchi, +3 authors, Jun Horiguchi.
J Hum Genet, 2016 Jul 22; 62(1). PMID: 27439682
Review.
Towards tumor immunodiagnostics.
Helen Kourea, Vassiliki Kotoula.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563650    Free PMC article.
Review.
Immunological battlefield in gastric cancer and role of immunotherapies.
Minyu Wang, Rita A Busuttil, +2 authors, Alex Boussioutas.
World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605873    Free PMC article.
Review.
In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium.
J C L Alfonso, N S Schaadt, +5 authors, H Hatzikirou.
Sci Rep, 2016 Sep 24; 6. PMID: 27659691    Free PMC article.
RNA Sequencing to Predict Response to Neoadjuvant Anti-HER2 Therapy: A Secondary Analysis of the NeoALTTO Randomized Clinical Trial.
Debora Fumagalli, David Venet, +20 authors, Christos Sotiriou.
JAMA Oncol, 2016 Sep 30; 3(2). PMID: 27684533    Free PMC article.
Tumor Infiltrating Lymphocytes Affect the Outcome of Patients with Operable Triple-Negative Breast Cancer in Combination with Mutated Amino Acid Classes.
Vassiliki Kotoula, Sotiris Lakis, +18 authors, George Fountzilas.
PLoS One, 2016 Sep 30; 11(9). PMID: 27685159    Free PMC article.
Antibody-supervised deep learning for quantification of tumor-infiltrating immune cells in hematoxylin and eosin stained breast cancer samples.
Riku Turkki, Nina Linder, +2 authors, Johan Lundin.
J Pathol Inform, 2016 Oct 01; 7. PMID: 27688929    Free PMC article.
Correlation between serum IL-1β and miR-144-3p as well as their prognostic values in LUAD and LUSC patients.
Chen Wu, Bin Xu, +4 authors, Changping Wu.
Oncotarget, 2016 Nov 05; 7(52). PMID: 27811377    Free PMC article.
An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers.
Giulia Bottai, Carlotta Raschioni, +10 authors, Libero Santarpia.
Breast Cancer Res, 2016 Dec 04; 18(1). PMID: 27912781    Free PMC article.
The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment.
Shona A Hendry, Rae H Farnsworth, +3 authors, Stephen B Fox.
Front Immunol, 2017 Jan 10; 7. PMID: 28066431    Free PMC article.
Highly Cited. Review.
Integrated MicroRNA-mRNA Profiling Identifies Oncostatin M as a Marker of Mesenchymal-Like ER-Negative/HER2-Negative Breast Cancer.
Giulia Bottai, Lixia Diao, +6 authors, Libero Santarpia.
Int J Mol Sci, 2017 Jan 21; 18(1). PMID: 28106823    Free PMC article.
Cytokine profiling of tumor interstitial fluid of the breast and its relationship with lymphocyte infiltration and clinicopathological characteristics.
Jaime A Espinoza, Shakila Jabeen, +10 authors, Irina Gromova.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123884    Free PMC article.
Profiling of microRNAs in tumor interstitial fluid of breast tumors - a novel resource to identify biomarkers for prognostic classification and detection of cancer.
Ann Rita Halvorsen, Åslaug Helland, +7 authors, Vilde D Haakensen.
Mol Oncol, 2017 Feb 02; 11(2). PMID: 28145100    Free PMC article.
Non-anthracycline-containing docetaxel and cyclophosphamide regimen is associated with sustained worse outcome compared with docetaxel, anthracycline and cyclophosphamide in neoadjuvant treatment of triple negative and HER2-positive breast cancer patients: updated follow-up data from NATT study.
Xiaosong Chen, Guolin Ye, +2 authors, Kunwei Shen.
Chin J Cancer Res, 2017 Feb 09; 28(6). PMID: 28174484    Free PMC article.
Tumor-infiltrating lymphocyte composition, organization and PD-1/ PD-L1 expression are linked in breast cancer.
Laurence Buisseret, Soizic Garaud, +14 authors, Karen Willard-Gallo.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197375    Free PMC article.
Highly Cited.
PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma.
Jan Budczies, Gunhild Mechtersheimer, +17 authors, Albrecht Stenzinger.
Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405504    Free PMC article.
Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer.
Sotirios P Fortis, Michael Sofopoulos, +9 authors, Constantin N Baxevanis.
J Immunother Cancer, 2017 Apr 22; 5. PMID: 28428887    Free PMC article.
Advancing Immunotherapy in Metastatic Breast Cancer.
Mariam Mansour, Zhi Ling Teo, Stephen J Luen, Sherene Loi.
Curr Treat Options Oncol, 2017 May 24; 18(6). PMID: 28534250
Review.
Immune signature of metastatic breast cancer: Identifying predictive markers of immunotherapy response.
Ji-Yeon Kim, Eunjin Lee, +5 authors, Yeon Hee Park.
Oncotarget, 2017 May 26; 8(29). PMID: 28537889    Free PMC article.
Unmet Needs in Clinical Research in Breast Cancer: Where Do We Need to Go?
Ann H Partridge, Lisa A Carey.
Clin Cancer Res, 2017 Jun 03; 23(11). PMID: 28572255    Free PMC article.
Immunotherapy for Breast Cancer: What Are We Missing?
Robert H Vonderheide, Susan M Domchek, Amy S Clark.
Clin Cancer Res, 2017 Jun 03; 23(11). PMID: 28572258    Free PMC article.
Highly Cited.
Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer.
Emma Nolan, Peter Savas, +13 authors, Geoffrey J Lindeman.
Sci Transl Med, 2017 Jun 09; 9(393). PMID: 28592566    Free PMC article.
Highly Cited.
Precision medicine in breast cancer: reality or utopia?
Ali Bettaieb, Catherine Paul, +3 authors, François Ghiringhelli.
J Transl Med, 2017 Jun 19; 15(1). PMID: 28623955    Free PMC article.
Review.
Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition.
Carlos R Gil Del Alcazar, Sung Jin Huh, +27 authors, Kornelia Polyak.
Cancer Discov, 2017 Jun 28; 7(10). PMID: 28652380    Free PMC article.
Highly Cited.
Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers.
Xia Liu, Julia Y S Tsang, +5 authors, Gary M Tse.
Oncologist, 2017 Jul 14; 22(11). PMID: 28701569    Free PMC article.
Adding Adjuvant Systemic Treatment after Neoadjuvant Therapy in Breast Cancer: Review of the Data.
Shetal A Patel, Angela DeMichele.
Curr Oncol Rep, 2017 Jul 25; 19(8). PMID: 28733827
Review.
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.
Shona Hendry, Roberto Salgado, +97 authors, Stephen B Fox.
Adv Anat Pathol, 2017 Aug 05; 24(5). PMID: 28777142    Free PMC article.
Highly Cited. Review.
Chronology of gastrointestinal cancer.
Kentaro Murakami, Hisahiro Matsubara.
Surg Today, 2017 Aug 11; 48(4). PMID: 28795270    Free PMC article.
Review.
Breast Cancer Immunotherapy: Facts and Hopes.
Leisha A Emens.
Clin Cancer Res, 2017 Aug 13; 24(3). PMID: 28801472    Free PMC article.
Highly Cited. Review.
Clinical Validity and Utility of Tumor-Infiltrating Lymphocytes in Routine Clinical Practice for Breast Cancer Patients: Current and Future Directions.
Lironne Wein, Peter Savas, +3 authors, Sherene Loi.
Front Oncol, 2017 Aug 22; 7. PMID: 28824872    Free PMC article.
Review.
Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer.
Nicholas A Taylor, Sarah C Vick, +10 authors, Jonathan S Serody.
J Clin Invest, 2017 Aug 22; 127(9). PMID: 28825599    Free PMC article.
Highly Cited.
Predictive and prognostic impact of tumour-infiltrating lymphocytes in triple-negative breast cancer treated with neoadjuvant chemotherapy.
Carmen Herrero-Vicent, Angel Guerrero, +7 authors, Amparo Ruiz-Simón.
Ecancermedicalscience, 2017 Sep 14; 11. PMID: 28900472    Free PMC article.
Significance of evaluating tumor-infiltrating lymphocytes (TILs) and programmed cell death-ligand 1 (PD-L1) expression in breast cancer.
Sasagu Kurozumi, Takaaki Fujii, +4 authors, Hiroyuki Kuwano.
Med Mol Morphol, 2017 Sep 25; 50(4). PMID: 28936553
Review.
Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer.
Yu-Chiao Chiu, Li-Ju Wang, +2 authors, Yidong Chen.
BMC Genomics, 2017 Oct 07; 18(Suppl 6). PMID: 28984209    Free PMC article.
PTPN2: a tumor suppressor you want deleted?
Florian Wiede, Tony Tiganis.
Immunol Cell Biol, 2017 Oct 11; 95(10). PMID: 28994418
Breast Cancer Vaccines: New Insights.
Rosaria Benedetti, Carmela Dell'Aversana, +2 authors, Lucia Altucci.
Front Endocrinol (Lausanne), 2017 Oct 31; 8. PMID: 29081765    Free PMC article.
Review.
DNA methylation at enhancers identifies distinct breast cancer lineages.
Thomas Fleischer, Xavier Tekpli, +14 authors, Vessela N Kristensen.
Nat Commun, 2017 Nov 11; 8(1). PMID: 29123100    Free PMC article.
T cell receptor sequencing of early-stage breast cancer tumors identifies altered clonal structure of the T cell repertoire.
John F Beausang, Amanda J Wheeler, +4 authors, Stephen R Quake.
Proc Natl Acad Sci U S A, 2017 Nov 16; 114(48). PMID: 29138313    Free PMC article.
Targeting immune checkpoints in breast cancer: an update of early results.
Cinzia Solinas, Andrea Gombos, +3 authors, Laurence Buisseret.
ESMO Open, 2017 Nov 28; 2(5). PMID: 29177095    Free PMC article.
Review.
Interplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy.
Aura Muntasell, Mariona Cabo, +6 authors, Miguel López-Botet.
Front Immunol, 2017 Nov 29; 8. PMID: 29181007    Free PMC article.
Review.
Implications of the tumor immune microenvironment for staging and therapeutics.
Janis M Taube, Jérôme Galon, +8 authors, Ashley Cimino-Mathews.
Mod Pathol, 2017 Dec 02; 31(2). PMID: 29192647    Free PMC article.
Highly Cited. Review.
Prediction of survival after neoadjuvant chemotherapy for breast cancer by evaluation of tumor-infiltrating lymphocytes and residual cancer burden.
Yuka Asano, Shinichiro Kashiwagi, +11 authors, Masaichi Ohira.
BMC Cancer, 2017 Dec 29; 17(1). PMID: 29282021    Free PMC article.
Immune Checkpoint Blockade for Breast Cancer.
April Swoboda, Rita Nanda.
Cancer Treat Res, 2018 Jan 20; 173. PMID: 29349763    Free PMC article.
Review.
Immune gene expression and response to chemotherapy in advanced breast cancer.
Theodoros Foukakis, John Lövrot, +14 authors, Thomas Hatschek.
Br J Cancer, 2018 Jan 26; 118(4). PMID: 29370583    Free PMC article.
Analysis of tumour-infiltrating lymphocytes reveals two new biologically different subgroups of breast ductal carcinoma in situ.
Marie Beguinot, Marie-Melanie Dauplat, +5 authors, Nina Radosevic-Robin.
BMC Cancer, 2018 Feb 06; 18(1). PMID: 29394917    Free PMC article.
Analysis of PD1, PDL1, PDL2 expression and T cells infiltration in 1014 gastric cancer patients.
Xiaofang Xing, Jianping Guo, +23 authors, Jiafu Ji.
Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399387    Free PMC article.
Highly Cited.
Predicting the Efficacy of HER2-Targeted Therapies: A Look at the Host.
Martina Di Modica, Elda Tagliabue, Tiziana Triulzi.
Dis Markers, 2018 Feb 07; 2017. PMID: 29403144    Free PMC article.
Review.
Immune Infiltration in Invasive Lobular Breast Cancer.
Christine Desmedt, Roberto Salgado, +21 authors, Christos Sotiriou.
J Natl Cancer Inst, 2018 Feb 23; 110(7). PMID: 29471435    Free PMC article.
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis.
Constantinos Roufas, Dimitrios Chasiotis, +3 authors, Apostolos Zaravinos.
Front Oncol, 2018 Mar 09; 8. PMID: 29515971    Free PMC article.
Study on the progression types of cancer in patients with breast cancer undergoing eribulin chemotherapy and tumor microenvironment.
Shinichiro Kashiwagi, Gen Tsujio, +10 authors, Masaichi Ohira.
J Transl Med, 2018 Mar 11; 16(1). PMID: 29523158    Free PMC article.
Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Endocrine Therapy for Stage IV Breast Cancer.
Nozomi Iimori, Shinichiro Kashiwagi, +9 authors, Masaichi Ohira.
In Vivo, 2018 Apr 27; 32(3). PMID: 29695577    Free PMC article.
Checkpoint Inhibitors in the Treatment of Breast Cancer.
Tomas G Lyons, Maura N Dickler, Elizabeth E Comen.
Curr Oncol Rep, 2018 May 02; 20(7). PMID: 29713831
Review.
Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4.
Lina Prasmickaite, Ellen M Tenstad, +10 authors, Gunhild M Maelandsmo.
Mol Oncol, 2018 May 10; 12(9). PMID: 29741811    Free PMC article.
Immune characterization of breast cancer metastases: prognostic implications.
Maria Vittoria Dieci, Vassilena Tsvetkova, +15 authors, Valentina Guarneri.
Breast Cancer Res, 2018 Jun 23; 20(1). PMID: 29929548    Free PMC article.
Probabilistic graphical models relate immune status with response to neoadjuvant chemotherapy in breast cancer.
Andrea Zapater-Moros, Angelo Gámez-Pozo, +9 authors, Juan Ángel Fresno Vara.
Oncotarget, 2018 Jul 03; 9(45). PMID: 29963222    Free PMC article.
Human cancer evolution in the context of a human immune system in mice.
Odd L Gammelgaard, Mikkel G Terp, Birgitte Preiss, Henrik J Ditzel.
Mol Oncol, 2018 Aug 19; 12(10). PMID: 30120895    Free PMC article.
Magnetic resonance imaging and molecular features associated with tumor-infiltrating lymphocytes in breast cancer.
Jia Wu, Xuejie Li, +4 authors, Ruijiang Li.
Breast Cancer Res, 2018 Sep 05; 20(1). PMID: 30176944    Free PMC article.
Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models.
Roberto R Rosato, Daniel Dávila-González, +6 authors, Jenny C Chang.
Breast Cancer Res, 2018 Sep 07; 20(1). PMID: 30185216    Free PMC article.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Review.
Platelet-to-lymphocyte ratio as a predictive factor of complete pathologic response to neoadjuvant chemotherapy in breast cancer.
Javier Cuello-López, Ana Fidalgo-Zapata, Laura López-Agudelo, Elsa Vásquez-Trespalacios.
PLoS One, 2018 Nov 15; 13(11). PMID: 30427884    Free PMC article.
Predictive value of lymphocyte-to-monocyte ratio in the preoperative setting for progression of patients with breast cancer.
Wataru Goto, Shinichiro Kashiwagi, +8 authors, Masaichi Ohira.
BMC Cancer, 2018 Nov 21; 18(1). PMID: 30453914    Free PMC article.
Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer.
Soizic Garaud, Pawel Zayakin, +7 authors, Aija Linē.
Front Immunol, 2018 Dec 06; 9. PMID: 30515157    Free PMC article.
Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, BRCA1-like status, tumor-infiltrating immune cells and survival.
Marcelo Sobral-Leite, Koen Van de Vijver, +21 authors, Marjanka K Schmidt.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524905    Free PMC article.
Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients.
Iva Truxova, Lenka Kasikova, +17 authors, Jitka Fucikova.
J Immunother Cancer, 2018 Dec 12; 6(1). PMID: 30526667    Free PMC article.
HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy.
Tiziana Triulzi, Luca Forte, +6 authors, Elda Tagliabue.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546951    Free PMC article.
The Neutrophil to Lymphocyte Ratio Predicts the Response to Neoadjuvant Chemotherapy in Luminal B Breast Cancer.
Mauricio Rivas, Francisco Acevedo, +14 authors, Cesar Sanchez.
Asian Pac J Cancer Prev, 2019 Jul 28; 20(7). PMID: 31350986    Free PMC article.
Programmed Cell Death Ligand 1 in Breast Cancer: Technical Aspects, Prognostic Implications, and Predictive Value.
Federica Miglietta, Gaia Griguolo, Valentina Guarneri, Maria Vittoria Dieci.
Oncologist, 2019 Aug 25; 24(11). PMID: 31444294    Free PMC article.
Review.
Tumor-infiltrating lymphocytes and CD8+ T cells predict survival of triple-negative breast cancer.
H Vihervuori, T A Autere, +5 authors, P Kronqvist.
J Cancer Res Clin Oncol, 2019 Sep 29; 145(12). PMID: 31562550    Free PMC article.
Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab.
Luciana Molinero, Yijin Li, +7 authors, Leisha A Emens.
J Immunother Cancer, 2019 Oct 28; 7(1). PMID: 31647026    Free PMC article.
Neutrophil-lymphocyte ratio in metastatic breast cancer is not an independent predictor of survival, but depends on other variables.
Alejandra Ivars Rubio, Juan Carlos Yufera, +8 authors, Francisco Ayala de la Peña.
Sci Rep, 2019 Nov 20; 9(1). PMID: 31740715    Free PMC article.
Quantitative and Qualitative Evaluation of Breast Cancer Prognosis: A Sonographic Elastography Study.
Yue You, Yu Song, +2 authors, Huaying Bo.
Med Sci Monit, 2019 Dec 06; 25. PMID: 31802780    Free PMC article.
Evaluation of the Predictive Role of Tumor Immune Infiltrate in Patients with HER2-Positive Breast Cancer Treated with Neoadjuvant Anti-HER2 Therapy without Chemotherapy.
Carmine De Angelis, Chandandeep Nagi, +22 authors, Rachel Schiff.
Clin Cancer Res, 2019 Oct 28; 26(3). PMID: 31653641    Free PMC article.
Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers.
Sherene Loi, Damien Drubay, +19 authors, Stefan Michiels.
J Clin Oncol, 2019 Jan 17; 37(7). PMID: 30650045    Free PMC article.
Highly Cited.
Changes in Tumor-Infiltrating Lymphocytes and Vascular Normalization in Breast Cancer Patients After Neoadjuvant Chemotherapy and Their Correlations With DFS.
Qiong Wang, Qun Xiang, +5 authors, Jing Cheng.
Front Oncol, 2020 Feb 11; 9. PMID: 32039020    Free PMC article.
Development of an Immune-Related Prognostic Signature in Breast Cancer.
Peiling Xie, Yuying Ma, +3 authors, Huimin Zhang.
Front Genet, 2020 Feb 13; 10. PMID: 32047513    Free PMC article.
Tumor-Infiltrating Lymphocytes in Patients Receiving Trastuzumab/Pertuzumab-Based Chemotherapy: A TRYPHAENA Substudy.
Michail Ignatiadis, Gert Van den Eynden, +16 authors, Christos Sotiriou.
J Natl Cancer Inst, 2018 May 23; 111(1). PMID: 29788230    Free PMC article.
Ductal carcinoma in situ: to treat or not to treat, that is the question.
Maartje van Seijen, Esther H Lips, +9 authors, PRECISION team.
Br J Cancer, 2019 Jul 10; 121(4). PMID: 31285590    Free PMC article.
Review.
Prognostic utility of tumor-infiltrating lymphocytes in residual tumor after neoadjuvant chemotherapy with trastuzumab for HER2-positive breast cancer.
Sasagu Kurozumi, Kenichi Inoue, +5 authors, Ken Shirabe.
Sci Rep, 2019 Feb 09; 9(1). PMID: 30733496    Free PMC article.
Relevance of Spatial Heterogeneity of Immune Infiltration for Predicting Risk of Recurrence After Endocrine Therapy of ER+ Breast Cancer.
Andreas Heindl, Ivana Sestak, +3 authors, Yinyin Yuan.
J Natl Cancer Inst, 2017 Sep 02; 110(2). PMID: 28859291    Free PMC article.
Checkpoint blockade in the treatment of breast cancer: current status and future directions.
Lironne Wein, Stephen J Luen, +2 authors, Sherene Loi.
Br J Cancer, 2018 May 29; 119(1). PMID: 29808015    Free PMC article.
Review.
Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non-Small Cell Lung Cancer.
Germán Corredor, Xiangxue Wang, +9 authors, Anant Madabhushi.
Clin Cancer Res, 2018 Sep 12; 25(5). PMID: 30201760    Free PMC article.
Evaluation of the Predictive and Prognostic Values of Stromal Tumor-Infiltrating Lymphocytes in HER2-Positive Breast Cancers treated with neoadjuvant chemotherapy.
Xia Yang, Jia Rao, Wentao Yang, Ruohong Shui.
Target Oncol, 2018 Nov 09; 13(6). PMID: 30406444    Free PMC article.
Association of tumor-infiltrating lymphocytes with distant disease-free survival in the ShortHER randomized adjuvant trial for patients with early HER2+ breast cancer.
M V Dieci, P Conte, +19 authors, V Guarneri.
Ann Oncol, 2019 Jan 19; 30(3). PMID: 30657852    Free PMC article.
Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers.
Tina Gruosso, Mathieu Gigoux, +20 authors, Morag Park.
J Clin Invest, 2019 Feb 13; 129(4). PMID: 30753167    Free PMC article.
Highly Cited.
Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.
Cecilia Roux, Soode Moghadas Jafari, +14 authors, Chiara Gorrini.
Proc Natl Acad Sci U S A, 2019 Feb 17; 116(10). PMID: 30770442    Free PMC article.
A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.
Zsófia Pénzváltó, Jane Qian Chen, +5 authors, Alexander D Borowsky.
J Mammary Gland Biol Neoplasia, 2019 Feb 28; 24(2). PMID: 30810966    Free PMC article.
Immune Tumor Microenvironment in Breast Cancer and the Participation of Estrogen and Its Receptors in Cancer Physiopathology.
Mariana Segovia-Mendoza, Jorge Morales-Montor.
Front Immunol, 2019 Mar 19; 10. PMID: 30881360    Free PMC article.
Review.
Interaction of host immunity with HER2-targeted treatment and tumor heterogeneity in HER2-positive breast cancer.
Gaia Griguolo, Tomás Pascual, +2 authors, Aleix Prat.
J Immunother Cancer, 2019 Mar 30; 7(1). PMID: 30922362    Free PMC article.
Review.
Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node.
Kim M van Pul, Ronald J C L M Vuylsteke, +5 authors, Tanja D de Gruijl.
J Immunother Cancer, 2019 May 24; 7(1). PMID: 31118093    Free PMC article.
Correlation Analysis of Histopathology and Proteogenomics Data for Breast Cancer.
Xiaohui Zhan, Jun Cheng, +7 authors, Kun Huang.
Mol Cell Proteomics, 2019 Jul 10; 18(8 suppl 1). PMID: 31285282    Free PMC article.
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes.
Mandeep Singh, Ghamdan Al-Eryani, +11 authors, Alexander Swarbrick.
Nat Commun, 2019 Jul 18; 10(1). PMID: 31311926    Free PMC article.
Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes.
Marcelo Sobral-Leite, Izhar Salomon, +13 authors, Marleen Kok.
Breast Cancer Res, 2019 Aug 09; 21(1). PMID: 31391067    Free PMC article.
BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer.
Lingeng Lu, Huatian Huang, +3 authors, Zuoheng Wang.
BMC Cancer, 2019 Apr 27; 19(1). PMID: 31023256    Free PMC article.
Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.
Rama Soundararajan, Jared J Fradette, +18 authors, Sendurai A Mani.
Cancers (Basel), 2019 May 30; 11(5). PMID: 31137625    Free PMC article.
Review.
KRAS signaling enriched triple negative breast cancer is associated with favorable tumor immune microenvironment and better survival.
Yoshihisa Tokumaru, Masanori Oshi, +7 authors, Kazuaki Takabe.
Am J Cancer Res, 2020 Apr 09; 10(3). PMID: 32266098    Free PMC article.
Sequential Anti-PD1 Therapy Following Dendritic Cell Vaccination Improves Survival in a HER2 Mammary Carcinoma Model and Identifies a Critical Role for CD4 T Cells in Mediating the Response.
Krithika N Kodumudi, Ganesan Ramamoorthi, +10 authors, Brian J Czerniecki.
Front Immunol, 2019 Sep 03; 10. PMID: 31475002    Free PMC article.
Emerging role of deep learning-based artificial intelligence in tumor pathology.
Yahui Jiang, Meng Yang, +2 authors, Yan Sun.
Cancer Commun (Lond), 2020 Apr 12; 40(4). PMID: 32277744    Free PMC article.
Review.
Prevalence of PD-L1 expression in matched recurrent and/or metastatic sarcoma samples and in a range of selected sarcomas subtypes.
Ana Cristina Vargas, Fiona M Maclean, +8 authors, Anthony J Gill.
PLoS One, 2020 Apr 16; 15(4). PMID: 32294103    Free PMC article.
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group.
Mohamed Amgad, Elisabeth Specht Stovgaard, +66 authors, International Immuno-Oncology Biomarker Working Group.
NPJ Breast Cancer, 2020 May 16; 6. PMID: 32411818    Free PMC article.
Review.
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.
Zuzana Kos, Elvire Roblin, +91 authors, International Immuno-Oncology Biomarker Working Group.
NPJ Breast Cancer, 2020 May 16; 6. PMID: 32411819    Free PMC article.
Fully Human Antibodies for Malignant Pleural Mesothelioma Targeting.
Fabio Nicolini, Martine Bocchini, +4 authors, Massimiliano Mazza.
Cancers (Basel), 2020 Apr 12; 12(4). PMID: 32276524    Free PMC article.
Review.
Tumour-infiltrating lymphocytes and response to neoadjuvant letrozole in patients with early oestrogen receptor-positive breast cancer: analysis from a nationwide phase II DBCG trial.
Signe Korsgaard Skriver, Maj-Britt Jensen, +2 authors, Anne-Vibeke Laenkholm.
Breast Cancer Res, 2020 May 16; 22(1). PMID: 32410705    Free PMC article.
microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics.
Marta Gomarasca, Paola Maroni, Giuseppe Banfi, Giovanni Lombardi.
Int J Mol Sci, 2020 Apr 23; 21(8). PMID: 32316552    Free PMC article.
Review.
Therapeutic Effect of Trastuzumab in Neoadjuvant-Treated HER2-Positive Breast Cancer with Low Infiltrating Level of Tumor-Infiltrating Lymphocytes.
Shiwei Liu, Exian Mou, +8 authors, Jia Xu.
Cancer Manag Res, 2020 May 23; 12. PMID: 32440212    Free PMC article.
Association of TILs with clinical parameters, Recurrence Score® results, and prognosis in patients with early HER2-negative breast cancer (BC)-a translational analysis of the prospective WSG PlanB trial.
Cornelia Kolberg-Liedtke, Oleg Gluz, +13 authors, Nadia Harbeck.
Breast Cancer Res, 2020 May 16; 22(1). PMID: 32408905    Free PMC article.
Racial differences in CD8+ T cell infiltration in breast tumors from Black and White women.
Yara Abdou, Kristopher Attwood, +9 authors, Angela R Omilian.
Breast Cancer Res, 2020 Jun 11; 22(1). PMID: 32517730    Free PMC article.
Targeting Autophagy Facilitates T Lymphocyte Migration by Inducing the Expression of CXCL10 in Gastric Cancer Cell Lines.
Qingyuan Meng, Yihong Zhang, Liangbiao George Hu.
Front Oncol, 2020 Jun 26; 10. PMID: 32582551    Free PMC article.
Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.
Zhe-Wei Wei, Jing Wu, +8 authors, Chang-Hua Zhang.
EBioMedicine, 2020 Jun 24; 57. PMID: 32574962    Free PMC article.
Independent Prognostic Value of Intratumoral Heterogeneity and Immune Response Features by Automated Digital Immunohistochemistry Analysis in Early Hormone Receptor-Positive Breast Carcinoma.
Dovile Zilenaite, Allan Rasmusson, +5 authors, Arvydas Laurinavicius.
Front Oncol, 2020 Jul 03; 10. PMID: 32612954    Free PMC article.
Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment Approach.
Yacine Bareche, Laurence Buisseret, +9 authors, Christos Sotiriou.
J Natl Cancer Inst, 2019 Oct 31; 112(7). PMID: 31665482    Free PMC article.
New Therapeutics in HER2-Positive Advanced Breast Cancer: Towards a Change in Clinical Practices?pi.
Essia Mezni, Cécile Vicier, +3 authors, Anthony Gonçalves.
Cancers (Basel), 2020 Jun 18; 12(6). PMID: 32545895    Free PMC article.
Review.
Extracranial Stereotactic Body Radiotherapy in Oligometastatic or Oligoprogressive Breast Cancer.
Fabian Weykamp, Laila König, +9 authors, Juliane Hörner-Rieber.
Front Oncol, 2020 Jul 18; 10. PMID: 32676455    Free PMC article.
Predicting therapeutic efficacy of endocrine therapy for stage IV breast cancer by tumor-infiltrating lymphocytes.
Yuka Asano, Shinichiro Kashiwagi, +8 authors, Masaichi Ohira.
Mol Clin Oncol, 2020 Jul 28; 13(2). PMID: 32714546    Free PMC article.
Prognostic value of neutrophil-to-lymphocyte ratio in human epidermal growth factor receptor 2-negative breast cancer patients who received neoadjuvant chemotherapy.
Soong June Bae, Yoon Jin Cha, +10 authors, Joon Jeong.
Sci Rep, 2020 Aug 06; 10(1). PMID: 32753659    Free PMC article.
Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Aradhana Rani, Justin Stebbing, Georgios Giamas, John Murphy.
Front Endocrinol (Lausanne), 2019 Jun 11; 10. PMID: 31178825    Free PMC article.
Highly Cited. Review.
Tumor immune microenvironment and immune checkpoint inhibitors in esophageal squamous cell carcinoma.
Yoshifumi Baba, Daichi Nomoto, +5 authors, Hideo Baba.
Cancer Sci, 2020 Jun 25; 111(9). PMID: 32579769    Free PMC article.
Review.
Association of sonographic features and molecular subtypes in predicting breast cancer disease outcomes.
Haoyu Wang, Jiejie Yao, +3 authors, Kunwei Shen.
Cancer Med, 2020 Jul 14;. PMID: 32657039    Free PMC article.
Primary and metastatic breast tumors cross-talk to influence immunotherapy responses.
Amanda J Oliver, Simon P Keam, +6 authors, Clare Y Slaney.
Oncoimmunology, 2020 Sep 18; 9(1). PMID: 32939322    Free PMC article.
SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women.
Angel Núñez-Marrero, Nelly Arroyo, +3 authors, Julie Dutil.
Oncotarget, 2020 Sep 26; 11(37). PMID: 32973967    Free PMC article.
Emerging Opportunities of Radiotherapy Combined With Immunotherapy in the Era of Breast Cancer Heterogeneity.
Pelagia G Tsoutsou, Khalil Zaman, +3 authors, Marie-Catherine Vozenin.
Front Oncol, 2019 Jan 09; 8. PMID: 30619749    Free PMC article.
Review.
Improved prognosis of low baseline neutrophil-to-lymphocyte ratio is significantly exclusive in breast cancer patients with high absolute counts of lymphocytes.
Yukie Fujimoto, Hiromi Ozawa, +4 authors, Yasuo Miyoshi.
Mol Clin Oncol, 2019 Jan 27; 10(2). PMID: 30680208    Free PMC article.
Prognostic significance of tumour-infiltrating lymphocytes for oestrogen receptor-negative breast cancer without lymph node metastasis.
Sasagu Kurozumi, Hiroshi Matsumoto, +6 authors, Hiroyuki Kuwano.
Oncol Lett, 2019 Mar 15; 17(3). PMID: 30867728    Free PMC article.
Effect of gastrointestinal microbiome and its diversity on the expression of tumor-infiltrating lymphocytes in breast cancer.
Jiajie Shi, Cuizhi Geng, +4 authors, Zheng Li.
Oncol Lett, 2019 Jun 13; 17(6). PMID: 31186716    Free PMC article.
Decoding Immune Heterogeneity of Triple Negative Breast Cancer and Its Association with Systemic Inflammation.
Sandra Romero-Cordoba, Elisabetta Meneghini, +6 authors, Francesca Bianchi.
Cancers (Basel), 2019 Jul 03; 11(7). PMID: 31261762    Free PMC article.
DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy.
Elaine Gilmore, Nuala McCabe, Richard D Kennedy, Eileen E Parkes.
J Oncol, 2019 Jul 20; 2019. PMID: 31320901    Free PMC article.
Review.
The Role of Breast Cancer Stem Cells as a Prognostic Marker and a Target to Improve the Efficacy of Breast Cancer Therapy.
Maria Giovanna Scioli, Gabriele Storti, +4 authors, Augusto Orlandi.
Cancers (Basel), 2019 Jul 25; 11(7). PMID: 31330794    Free PMC article.
Review.
PD-1/PD-L1 Targeting in Breast Cancer: The First Clinical Evidences Are Emerging. A Literature Review.
Gabrielle Planes-Laine, Philippe Rochigneux, +4 authors, Anthony Gonçalves.
Cancers (Basel), 2019 Jul 25; 11(7). PMID: 31336685    Free PMC article.
Highly Cited. Review.
Evaluating the prognostic significance of tumor-infiltrating lymphocytes in solid tumor: practice of a standardized method from the International Immuno-Oncology Biomarkers Working Group.
Jiu-Yang Liu, Gui-Fang Yang, Fang-Fang Chen, Chun-Wei Peng.
Cancer Manag Res, 2019 Aug 24; 11. PMID: 31440080    Free PMC article.
Diagnostic value of diffusion-weighted imaging-derived apparent diffusion coefficient and its association with histological prognostic factors in breast cancer.
Congcong Ren, Yu Zou, Xiaodan Zhang, Kui Li.
Oncol Lett, 2019 Aug 28; 18(3). PMID: 31452808    Free PMC article.
Small-Molecule Poly(ADP-ribose) Polymerase and PD-L1 Inhibitor Conjugates as Dual-Action Anticancer Agents.
Samuel Ofori, Samuel G Awuah.
ACS Omega, 2019 Aug 29; 4(7). PMID: 31460379    Free PMC article.
Chloride intracellular channel protein 2: prognostic marker and correlation with PD-1/PD-L1 in breast cancer.
Tao Xu, Zhi Wang, +3 authors, Xingrui Li.
Aging (Albany NY), 2020 Sep 12; 12(17). PMID: 32915772    Free PMC article.
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.
Ivy X Chen, Kathleen Newcomer, +8 authors, Rakesh K Jain.
Proc Natl Acad Sci U S A, 2020 Sep 11; 117(38). PMID: 32907939    Free PMC article.
Prognostic factors in phyllodes tumours of the breast: retrospective study on 166 consecutive cases.
Elisabetta Di Liso, Michele Bottosso, +14 authors, Valentina Guarneri.
ESMO Open, 2020 Oct 07; 5(5). PMID: 33020219    Free PMC article.
The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response.
Cui Jiang, Jingwei Liu, +13 authors, Liu Cao.
Int J Biol Sci, 2020 Oct 17; 16(15). PMID: 33061819    Free PMC article.
Breast Microinvasive Carcinoma With Different Morphologies: Analysis of Clinicopathologic Features of 121 Cases.
ChangYin Feng, QiaoLing Zheng, YingHong Yang.
Breast Cancer (Auckl), 2020 Oct 23; 14. PMID: 33088178    Free PMC article.
Breast and Gut Microbiota Action Mechanisms in Breast Cancer Pathogenesis and Treatment.
Aurora Laborda-Illanes, Lidia Sanchez-Alcoholado, +5 authors, María Isabel Queipo-Ortuño.
Cancers (Basel), 2020 Sep 04; 12(9). PMID: 32878124    Free PMC article.
Review.
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth.
Helene Rundqvist, Pedro Veliça, +10 authors, Randall S Johnson.
Elife, 2020 Oct 24; 9. PMID: 33095157    Free PMC article.
Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators.
Yitong Xu, Connie J Rogers.
Front Nutr, 2020 Nov 03; 7. PMID: 33134306    Free PMC article.
Review.
Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer.
Tong Lin, Yuqin Qiu, Wenya Peng, Lisheng Peng.
Biomed Res Int, 2020 Nov 05; 2020. PMID: 33145341    Free PMC article.
Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade.
Karsten A Pilones, Michal Hensler, +5 authors, Silvia C Formenti.
Oncoimmunology, 2020 Nov 06; 9(1). PMID: 33150045    Free PMC article.
Immune-Activated Regional Lymph Nodes Predict Favorable Survival in Early-Stage Triple-Negative Breast Cancer.
Yi-Yu Chen, Jing-Yu Ge, Ding Ma, Ke-Da Yu.
Front Oncol, 2020 Nov 10; 10. PMID: 33163401    Free PMC article.
Identification and Validation of an Immunological Expression-Based Prognostic Signature in Breast Cancer.
Jianying Pei, Yan Li, +6 authors, Yanping Li.
Front Genet, 2020 Nov 17; 11. PMID: 33193571    Free PMC article.
Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer.
Miaowei Wu, Weilei Hu, +2 authors, Xiao-Fang Yu.
Front Genet, 2020 Nov 17; 11. PMID: 33193702    Free PMC article.