. 2015 Dec;5(10).

Breast cancer intrinsic subtype classification, clinical use and future trends

Xiaofeng Dai 1 Ting Li 1 Zhonghu Bai 1 Yankun Yang 1 Xiuxia Liu 1 Jinling Zhan 1 Bozhi Shi 2 
  • PMID: 26693050
  •     85 References
  •     215 citations


Breast cancer is composed of multiple subtypes with distinct morphologies and clinical implications. The advent of microarrays has led to a new paradigm in deciphering breast cancer heterogeneity, based on which the intrinsic subtyping system using prognostic multigene classifiers was developed. Subtypes identified using different gene panels, though overlap to a great extent, do not completely converge, and the avail of new information and perspectives has led to the emergence of novel subtypes, which complicate our understanding towards breast tumor heterogeneity. This review explores and summarizes the existing intrinsic subtypes, patient clinical features and management, commercial signature panels, as well as various information used for tumor classification. Two trends are pointed out in the end on breast cancer subtyping, i.e., either diverging to more refined groups or converging to the major subtypes. This review improves our understandings towards breast cancer intrinsic classification, current status on clinical application, and future trends.

Keywords: Breast cancer; classification; clinical use; gene expression profiling; heterogeneity; intrinsic subtype; signature; trends.

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Free PMC article 
Development and validation of gene expression profile signatures in early-stage breast cancer.
Christine Desmedt, Christos Sotiriou, Martine J Piccart-Gebhart.
Cancer Invest, 2009 Feb 05; 27(1). PMID: 19191098
Breast cancer classification according to immunohistochemical markers: clinicopathologic features and short-term survival analysis in a population-based study from the South of Switzerland.
A Spitale, P Mazzola, +2 authors, A Bordoni.
Ann Oncol, 2008 Dec 17; 20(4). PMID: 19074747
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
Yoichi Nagata, Keng-Hsueh Lan, +10 authors, Dihua Yu.
Cancer Cell, 2004 Aug 25; 6(2). PMID: 15324695
Highly Cited.
Prevalence and correlates of HIV testing among sexually active African American adolescents in 4 US cities.
Rebecca R Swenson, Christie J Rizzo, +8 authors, Michael Hennessy.
Sex Transm Dis, 2009 Aug 08; 36(9). PMID: 19661840    Free PMC article.
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
Brian D Lehmann, Joshua A Bauer, +4 authors, Jennifer A Pietenpol.
J Clin Invest, 2011 Jun 03; 121(7). PMID: 21633166    Free PMC article.
Highly Cited.
Gene expression profiling in breast cancer: classification, prognostication, and prediction.
Jorge S Reis-Filho, Lajos Pusztai.
Lancet, 2011 Nov 22; 378(9805). PMID: 22098854
Highly Cited. Review.
Molecular mechanisms of long noncoding RNAs.
Kevin C Wang, Howard Y Chang.
Mol Cell, 2011 Sep 20; 43(6). PMID: 21925379    Free PMC article.
Highly Cited. Review.
A pathway-based classification of human breast cancer.
Michael L Gatza, Joseph E Lucas, +8 authors, Joseph R Nevins.
Proc Natl Acad Sci U S A, 2010 Mar 26; 107(15). PMID: 20335537    Free PMC article.
Highly Cited.
MYC-microRNA-9-metastasis connection in breast cancer.
Maria Inês Almeida, Rui M Reis, George A Calin.
Cell Res, 2010 May 27; 20(6). PMID: 20502442
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.
Howard Y Chang, Dimitry S A Nuyten, +10 authors, Marc J van de Vijver.
Proc Natl Acad Sci U S A, 2005 Feb 11; 102(10). PMID: 15701700    Free PMC article.
Highly Cited.
Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation.
E A Rakha, T C Putti, +6 authors, I O Ellis.
J Pathol, 2006 Jan 24; 208(4). PMID: 16429394
CpG island methylator phenotype in colorectal cancer.
M Toyota, N Ahuja, +3 authors, J P Issa.
Proc Natl Acad Sci U S A, 1999 Jul 21; 96(15). PMID: 10411935    Free PMC article.
Highly Cited.
Comparison of PAM50 risk of recurrence score with oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy.
Mitch Dowsett, Ivana Sestak, +7 authors, Jack Cuzick.
J Clin Oncol, 2013 Jul 03; 31(22). PMID: 23816962
Highly Cited.
Phylogenetic shadowing and computational identification of human microRNA genes.
Eugene Berezikov, Victor Guryev, +3 authors, Edwin Cuppen.
Cell, 2005 Jan 18; 120(1). PMID: 15652478
Highly Cited.
High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses.
Dalia M Abd El-Rehim, Graham Ball, +6 authors, Ian O Ellis.
Int J Cancer, 2005 Apr 09; 116(3). PMID: 15818618
Highly Cited.
Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma.
Torsten O Nielsen, Forrest D Hsu, +13 authors, Charles M Perou.
Clin Cancer Res, 2004 Aug 26; 10(16). PMID: 15328174
Highly Cited.
Supervised risk predictor of breast cancer based on intrinsic subtypes.
Joel S Parker, Michael Mullins, +17 authors, Philip S Bernard.
J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204204    Free PMC article.
Highly Cited.
Long noncoding RNA profiles reveal three molecular subtypes in glioma.
Rui Li, Jin Qian, +2 authors, Yong-Ping You.
CNS Neurosci Ther, 2014 Jan 08; 20(4). PMID: 24393335    Free PMC article.
Integrative investigation on breast cancer in ER, PR and HER2-defined subgroups using mRNA and miRNA expression profiling.
Xiaofeng Dai, Ana Chen, Zhonghu Bai.
Sci Rep, 2014 Oct 24; 4. PMID: 25338681    Free PMC article.
Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer.
Marc Buyse, Sherene Loi, +18 authors, TRANSBIG Consortium.
J Natl Cancer Inst, 2006 Sep 07; 98(17). PMID: 16954471
Highly Cited.
MicroRNA and cancer.
Martin D Jansson, Anders H Lund.
Mol Oncol, 2012 Oct 30; 6(6). PMID: 23102669    Free PMC article.
Highly Cited. Review.
Molecular portraits of human breast tumours.
C M Perou, T Sørlie, +15 authors, D Botstein.
Nature, 2000 Aug 30; 406(6797). PMID: 10963602
Highly Cited.
Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support.
Kai-Chien Yang, Kathryn A Yamada, +6 authors, Jeanne M Nerbonne.
Circulation, 2014 Jan 17; 129(9). PMID: 24429688    Free PMC article.
Highly Cited.
Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study.
Mitch Dowsett, Jack Cuzick, +11 authors, Steven Shak.
J Clin Oncol, 2010 Mar 10; 28(11). PMID: 20212256
Highly Cited.
Gene expression profiling predicts clinical outcome of breast cancer.
Laura J van 't Veer, Hongyue Dai, +13 authors, Stephen H Friend.
Nature, 2002 Feb 02; 415(6871). PMID: 11823860
Highly Cited.
Luminal B breast cancer: molecular characterization, clinical management, and future perspectives.
Felipe Ades, Dimitrios Zardavas, +6 authors, Martine Piccart.
J Clin Oncol, 2014 Jul 23; 32(25). PMID: 25049332
Highly Cited. Review.
microRNA-205 regulates HER3 in human breast cancer.
Marilena V Iorio, Patrizia Casalini, +6 authors, Elda Tagliabue.
Cancer Res, 2009 Mar 12; 69(6). PMID: 19276373
Highly Cited.
The molecular portraits of breast tumors are conserved across microarray platforms.
Zhiyuan Hu, Cheng Fan, +28 authors, Charles M Perou.
BMC Genomics, 2006 Apr 29; 7. PMID: 16643655    Free PMC article.
Highly Cited.
A microRNA expression signature of human solid tumors defines cancer gene targets.
Stefano Volinia, George A Calin, +15 authors, Carlo M Croce.
Proc Natl Acad Sci U S A, 2006 Feb 08; 103(7). PMID: 16461460    Free PMC article.
Highly Cited.
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies.
Fiona M Blows, Kristy E Driver, +40 authors, David Huntsman.
PLoS Med, 2010 Jun 04; 7(5). PMID: 20520800    Free PMC article.
Highly Cited.
Predicting distant recurrence in receptor-positive breast cancer patients with limited clinicopathological risk: using the PAM50 Risk of Recurrence score in 1478 postmenopausal patients of the ABCSG-8 trial treated with adjuvant endocrine therapy alone.
M Gnant, M Filipits, +22 authors, Austrian Breast and Colorectal Cancer Study Group.
Ann Oncol, 2013 Dec 19; 25(2). PMID: 24347518
Highly Cited.
Effect of molecular disease subsets on disease-free survival in randomized adjuvant chemotherapy trials for estrogen receptor-positive breast cancer.
Lajos Pusztai, Kristine Broglio, +3 authors, Gabriel N Hortobagyi.
J Clin Oncol, 2008 Jul 30; 26(28). PMID: 18662965
Molecular classifications of breast carcinoma with similar terminology and different definitions: are they the same?
Ping Tang, Jianmin Wang, Patria Bourne.
Hum Pathol, 2008 Feb 22; 39(4). PMID: 18289638
Predicting prognosis of breast cancer with gene signatures: are we lost in a sea of data?
Takayuki Iwamoto, Lajos Pusztai.
Genome Med, 2010 Nov 26; 2(11). PMID: 21092148    Free PMC article.
Subtypes of breast cancer show preferential site of relapse.
Marcel Smid, Yixin Wang, +5 authors, John W M Martens.
Cancer Res, 2008 May 03; 68(9). PMID: 18451135
Highly Cited.
Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures.
Pratyaksha Wirapati, Christos Sotiriou, +10 authors, Mauro Delorenzi.
Breast Cancer Res, 2008 Jul 30; 10(4). PMID: 18662380    Free PMC article.
Highly Cited.
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Therese Sorlie, Robert Tibshirani, +13 authors, David Botstein.
Proc Natl Acad Sci U S A, 2003 Jun 28; 100(14). PMID: 12829800    Free PMC article.
Highly Cited.
SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer.
Marjan E Askarian-Amiri, Joanna Crawford, +12 authors, John S Mattick.
RNA, 2011 Apr 05; 17(5). PMID: 21460236    Free PMC article.
Highly Cited.
Hypermethylation in histologically distinct classes of breast cancer.
Young Kyung Bae, Amy Brown, +5 authors, Edward Gabrielson.
Clin Cancer Res, 2004 Sep 28; 10(18 Pt 1). PMID: 15447983
Non-coding RNAs in human disease.
Manel Esteller.
Nat Rev Genet, 2011 Nov 19; 12(12). PMID: 22094949
Highly Cited. Review.
The CpG island methylator phenotype in breast cancer is associated with the lobular subtype.
Jessica Roessler, Ole Ammerpohl, +15 authors, Ulrich Lehmann.
Epigenomics, 2014 Oct 28; 7(2). PMID: 25347269
Concordance among gene-expression-based predictors for breast cancer.
Cheng Fan, Daniel S Oh, +5 authors, Charles M Perou.
N Engl J Med, 2006 Aug 11; 355(6). PMID: 16899776
Highly Cited.
The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine.
Peng Qi, Xiang Du.
Mod Pathol, 2012 Sep 22; 26(2). PMID: 22996375
Highly Cited. Review.
Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study.
Katie M O'Brien, Stephen R Cole, +6 authors, Robert C Millikan.
Clin Cancer Res, 2010 Dec 21; 16(24). PMID: 21169259    Free PMC article.
Highly Cited.
Breast cancer classification and prognosis based on gene expression profiles from a population-based study.
Christos Sotiriou, Soek-Ying Neo, +7 authors, Edison T Liu.
Proc Natl Acad Sci U S A, 2003 Aug 15; 100(18). PMID: 12917485    Free PMC article.
Highly Cited.
Improvement of the clinical applicability of the Genomic Grade Index through a qRT-PCR test performed on frozen and formalin-fixed paraffin-embedded tissues.
Jérôme Toussaint, Anieta M Sieuwerts, +8 authors, Christos Sotiriou.
BMC Genomics, 2009 Sep 12; 10. PMID: 19744330    Free PMC article.
The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade.
Britta Weigelt, Frederick L Baehner, Jorge S Reis-Filho.
J Pathol, 2009 Nov 21; 220(2). PMID: 19927298
Highly Cited. Review.
Palbociclib for the Treatment of Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer.
Aki Morikawa, N Lynn Henry.
Clin Cancer Res, 2015 Jun 24; 21(16). PMID: 26100274    Free PMC article.
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype.
Cherie Blenkiron, Leonard D Goldstein, +10 authors, Eric A Miska.
Genome Biol, 2007 Oct 10; 8(10). PMID: 17922911    Free PMC article.
Highly Cited.
MicroRNAs in human cancer.
Thalia A Farazi, Jessica I Hoell, Pavel Morozov, Thomas Tuschl.
Adv Exp Med Biol, 2013 Feb 05; 774. PMID: 23377965    Free PMC article.
Highly Cited. Review.
Clinical applications for microRNAs in cancer.
S P Nana-Sinkam, C M Croce.
Clin Pharmacol Ther, 2012 Dec 06; 93(1). PMID: 23212103
Highly Cited. Review.
Breast cancer molecular profiling with single sample predictors: a retrospective analysis.
Britta Weigelt, Alan Mackay, +5 authors, Jorge S Reis-Filho.
Lancet Oncol, 2010 Feb 26; 11(4). PMID: 20181526
Highly Cited.
Linking signaling pathways to transcriptional programs in breast cancer.
Hatice U Osmanbeyoglu, Raphael Pelossof, Jacqueline F Bromberg, Christina S Leslie.
Genome Res, 2014 Sep 04; 24(11). PMID: 25183703    Free PMC article.
A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.
Xiao-Jun Ma, Zuncai Wang, +27 authors, Dennis C Sgroi.
Cancer Cell, 2004 Jun 15; 5(6). PMID: 15193263
Highly Cited.
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer.
Yixin Wang, Jan G M Klijn, +11 authors, John A Foekens.
Lancet, 2005 Feb 22; 365(9460). PMID: 15721472
Highly Cited.
Long noncoding RNA in prostate, bladder, and kidney cancer.
Elena S Martens-Uzunova, René Böttcher, +3 authors, George A Calin.
Eur Urol, 2014 Jan 01; 65(6). PMID: 24373479
Highly Cited. Review.
Risk factors for breast cancer according to estrogen and progesterone receptor status.
Graham A Colditz, Bernard A Rosner, +2 authors, Susan E Hankinson.
J Natl Cancer Inst, 2004 Feb 05; 96(3). PMID: 14759989
Highly Cited.
MicroRNA expression profiling in male and female familial breast cancer.
R Pinto, S De Summa, +7 authors, S Tommasi.
Br J Cancer, 2014 Nov 14; 111(12). PMID: 25393370    Free PMC article.
miRNAs and long noncoding RNAs as biomarkers in human diseases.
Katrien Van Roosbroeck, Jeroen Pollet, George A Calin.
Expert Rev Mol Diagn, 2013 Mar 13; 13(2). PMID: 23477558
Molecular classification and molecular forecasting of breast cancer: ready for clinical application?
James D Brenton, Lisa A Carey, Ahmed Ashour Ahmed, Carlos Caldas.
J Clin Oncol, 2005 Sep 08; 23(29). PMID: 16145060
Highly Cited. Review.
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Christina Curtis, Sohrab P Shah, +29 authors, Samuel Aparicio.
Nature, 2012 Apr 24; 486(7403). PMID: 22522925    Free PMC article.
Highly Cited.
MicroRNA expression profiling of male breast cancer.
Matteo Fassan, Raffaele Baffa, +8 authors, Anne Rosenberg.
Breast Cancer Res, 2009 Aug 12; 11(4). PMID: 19664288    Free PMC article.
Comprehensive molecular portraits of human breast tumours.
Cancer Genome Atlas Network.
Nature, 2012 Sep 25; 490(7418). PMID: 23000897    Free PMC article.
Highly Cited.
Gene-expression signatures in breast cancer.
Christos Sotiriou, Lajos Pusztai.
N Engl J Med, 2009 Feb 21; 360(8). PMID: 19228622
Highly Cited. Review.
The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma.
Rocío Montes de Oca, Zachary A Gurard-Levin, +12 authors, Geneviève Almouzni.
Mol Oncol, 2014 Dec 17; 9(3). PMID: 25497280    Free PMC article.
Epigenetics and colorectal cancer.
Victoria Valinluck Lao, William M Grady.
Nat Rev Gastroenterol Hepatol, 2011 Oct 20; 8(12). PMID: 22009203    Free PMC article.
Highly Cited. Review.
miRBase: tools for microRNA genomics.
Sam Griffiths-Jones, Harpreet Kaur Saini, Stijn van Dongen, Anton J Enright.
Nucleic Acids Res, 2007 Nov 10; 36(Database issue). PMID: 17991681    Free PMC article.
Highly Cited.
Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.
Maggie C U Cheang, Stephen K Chia, +10 authors, Torsten O Nielsen.
J Natl Cancer Inst, 2009 May 14; 101(10). PMID: 19436038    Free PMC article.
Highly Cited.
MicroRNA gene expression deregulation in human breast cancer.
Marilena V Iorio, Manuela Ferracin, +17 authors, Carlo M Croce.
Cancer Res, 2005 Aug 17; 65(16). PMID: 16103053
Highly Cited.
Molecular profiling: moving away from tumor philately.
Jorge S Reis-Filho, Britta Weigelt, Debora Fumagalli, Christos Sotiriou.
Sci Transl Med, 2010 Sep 03; 2(47). PMID: 20811040
A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer.
Xiao-Jun Ma, Ranelle Salunga, +8 authors, Dennis Sgroi.
Clin Cancer Res, 2008 May 03; 14(9). PMID: 18451222
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis.
Christos Sotiriou, Pratyaksha Wirapati, +17 authors, Mauro Delorenzi.
J Natl Cancer Inst, 2006 Feb 16; 98(4). PMID: 16478745
Highly Cited.
miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells.
R Spizzo, M S Nicoloso, +12 authors, G A Calin.
Cell Death Differ, 2009 Sep 05; 17(2). PMID: 19730444    Free PMC article.
Highly Cited.
A gene-expression signature as a predictor of survival in breast cancer.
Marc J van de Vijver, Yudong D He, +18 authors, René Bernards.
N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681
Highly Cited.
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.
Kathy S Albain, William E Barlow, +20 authors, Breast Cancer Intergroup of North America.
Lancet Oncol, 2009 Dec 17; 11(1). PMID: 20005174    Free PMC article.
Highly Cited.
Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer.
Anna V Ivshina, Joshy George, +12 authors, Lance D Miller.
Cancer Res, 2006 Nov 03; 66(21). PMID: 17079448
Highly Cited.
Breast cancer classification according to immunohistochemistry markers: subtypes and association with clinicopathologic variables in a peruvian hospital database.
Carlos S Vallejos, Henry L Gómez, +8 authors, Carlos E Vigil.
Clin Breast Cancer, 2010 Aug 14; 10(4). PMID: 20705562
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
T Sørlie, C M Perou, +14 authors, A L Børresen-Dale.
Proc Natl Acad Sci U S A, 2001 Sep 13; 98(19). PMID: 11553815    Free PMC article.
Highly Cited.
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.
Maria E Figueroa, Sanne Lugthart, +14 authors, Ari Melnick.
Cancer Cell, 2010 Jan 12; 17(1). PMID: 20060365    Free PMC article.
Highly Cited.
Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer--results of a large case-control study.
Sascha Abbas, Jakob Linseisen, +4 authors, Jenny Chang-Claude.
Carcinogenesis, 2007 Nov 03; 29(1). PMID: 17974532
Long non-coding RNAs: insights into functions.
Tim R Mercer, Marcel E Dinger, John S Mattick.
Nat Rev Genet, 2009 Feb 04; 10(3). PMID: 19188922
Highly Cited. Review.
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer.
Gianpiero Di Leva, Pierluigi Gasparini, +12 authors, Carlo M Croce.
J Natl Cancer Inst, 2010 Apr 15; 102(10). PMID: 20388878    Free PMC article.
Highly Cited.
Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study.
Lisa A Carey, Charles M Perou, +14 authors, Robert C Millikan.
JAMA, 2006 Jun 08; 295(21). PMID: 16757721
Highly Cited.
Prolactin-induced protein as a potential therapy response marker of adjuvant chemotherapy in breast cancer patients.
Karolina Jablonska, Jedrzej Grzegrzolka, +10 authors, Piotr Dziegiel.
Am J Cancer Res, 2016 Jun 14; 6(5). PMID: 27293986    Free PMC article.
PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT.
Xue Liu, Qian Chen, +8 authors, Xiu-Wu Bian.
Tumour Biol, 2016 Jul 29; 37(10). PMID: 27465552
Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool.
Karen J Meaburn.
Front Genet, 2016 Aug 11; 7. PMID: 27507988    Free PMC article.
Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients.
Danian Dai, Bo Chen, +4 authors, Weidong Wei.
PLoS One, 2016 Aug 26; 11(8). PMID: 27561099    Free PMC article.
A perspective on anti-EGFR therapies targeting triple-negative breast cancer.
Katsuya Nakai, Mien-Chie Hung, Hirohito Yamaguchi.
Am J Cancer Res, 2016 Sep 21; 6(8). PMID: 27648353    Free PMC article.
Highly Cited. Review.
Pretreatment TG/HDL-C Ratio Is Superior to Triacylglycerol Level as an Independent Prognostic Factor for the Survival of Triple Negative Breast Cancer Patients.
Danian Dai, Bo Chen, +6 authors, Weidong Wei.
J Cancer, 2016 Oct 05; 7(12). PMID: 27698913    Free PMC article.
Exploring the intrinsic differences among breast tumor subtypes defined using immunohistochemistry markers based on the decision tree.
Yang Li, Xu-Qing Tang, Zhonghu Bai, Xiaofeng Dai.
Sci Rep, 2016 Oct 28; 6. PMID: 27786176    Free PMC article.
Common profiles of Notch signaling differentiate disease-free survival in luminal type A and triple negative breast cancer.
Magdalena Orzechowska, Dorota Jędroszka, Andrzej K Bednarek.
Oncotarget, 2016 Nov 27; 8(4). PMID: 27888801    Free PMC article.
Association of CCND1 Gene c.870G>A Polymorphism with Breast Cancer Risk: A Case-ControlStudy and a Meta-Analysis.
Zahra Soleimani, Davood Kheirkhah, +3 authors, Younes Aftabi.
Pathol Oncol Res, 2016 Dec 23; 23(3). PMID: 28004353
Tissue Factor promotes breast cancer stem cell activity in vitro.
Hudhaifah Shaker, Hannah Harrison, +4 authors, Cliona C Kirwan.
Oncotarget, 2016 Dec 30; 8(16). PMID: 28033108    Free PMC article.
Epigenomic Inactivation of RasGAPs Activates RAS Signaling in a Subset of Luminal B Breast Cancers.
Rosalie Sears, Joe W Gray.
Cancer Discov, 2017 Feb 09; 7(2). PMID: 28167613    Free PMC article.
Galectin-1 knockdown improves drug sensitivity of breast cancer by reducing P-glycoprotein expression through inhibiting the Raf-1/AP-1 signaling pathway.
Fang Wang, Pengwei Lv, +3 authors, Guangcheng Guo.
Oncotarget, 2017 Feb 18; 8(15). PMID: 28212576    Free PMC article.
Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells.
Yu-Wei Chang, Kamaleshwar P Singh.
PLoS One, 2017 Mar 23; 12(3). PMID: 28323900    Free PMC article.
Platinum-Based Drugs Differentially Affect the Ultrastructure of Breast Cancer Cell Types.
Shadia Al-Bahlani, Buthaina Al-Dhahli, +2 authors, Mohamed Al-Kindi.
Biomed Res Int, 2017 Apr 06; 2017. PMID: 28377926    Free PMC article.
HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer.
Tolga Acun, Natalie Doberstein, +4 authors, Thomas Ried.
OMICS, 2017 May 10; 21(5). PMID: 28481734    Free PMC article.
Going beyond genetics to discover cancer targets.
Gabriel J Sandoval, William C Hahn.
Genome Biol, 2017 May 24; 18(1). PMID: 28532420    Free PMC article.
Comparative diagnostic accuracy of 18F-FDG PET/CT for breast cancer recurrence.
Roberta Piva, Flavia Ticconi, +7 authors, Silvia Morbelli.
Breast Cancer (Dove Med Press), 2017 Jul 26; 9. PMID: 28740429    Free PMC article.
Integrated diagnostic network construction reveals a 4-gene panel and 5 cancer hallmarks driving breast cancer heterogeneity.
Xiaofeng Dai, Tongyan Hua, Tingting Hong.
Sci Rep, 2017 Jul 30; 7(1). PMID: 28754978    Free PMC article.
Papillotubular carcinoma with an invasive micropapillary carcinoma component of the breast, characterized by a rapid increase in size due to intra-tumoral hemorrhage: A case report.
Motonobu Watanabe, Ryota Matsuoka, +2 authors, Yasushi Iitsuka.
Int J Surg Case Rep, 2017 Aug 05; 38. PMID: 28778029    Free PMC article.
Potential Diagnostic and Therapeutic Applications of Oligonucleotide Aptamers in Breast Cancer.
Xiaoqiu Wu, Atik Badshah Shaikh, +4 authors, Ge Zhang.
Int J Mol Sci, 2017 Aug 26; 18(9). PMID: 28841163    Free PMC article.
De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance.
Vinay K Mittal, John F McDonald.
BMC Med Genomics, 2017 Aug 31; 10(1). PMID: 28851357    Free PMC article.
Splice variants of cytosolic polyadenylation element-binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis.
James T DeLigio, Grace Lin, Charles E Chalfant, Margaret A Park.
J Biol Chem, 2017 Sep 15; 292(43). PMID: 28904175    Free PMC article.
A pathways-based prediction model for classifying breast cancer subtypes.
Tong Wu, Yunfeng Wang, +2 authors, Jiawei Tian.
Oncotarget, 2017 Sep 25; 8(35). PMID: 28938599    Free PMC article.
Alternative Splicing in Breast Cancer and the Potential Development of Therapeutic Tools.
Nancy Martínez-Montiel, Maricruz Anaya-Ruiz, Martín Pérez-Santos, Rebeca D Martínez-Contreras.
Genes (Basel), 2017 Oct 06; 8(10). PMID: 28981467    Free PMC article.
Gene Expression Profiling in Breast Cancer and Its Effect on Therapy Selection in Early-Stage Breast Cancer.
E Nilüfer Güler.
Eur J Breast Health, 2017 Oct 31; 13(4). PMID: 29082373    Free PMC article.
Transforming Growth Factor-beta Regulation of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration.
Ibrahim Y Hachim, Manuel Villatoro, +5 authors, Jean-Jacques Lebrun.
Sci Rep, 2017 Nov 05; 7(1). PMID: 29101386    Free PMC article.
Polyphenols as Promising Drugs against Main Breast Cancer Signatures.
María Losada-Echeberría, María Herranz-López, Vicente Micol, Enrique Barrajón-Catalán.
Antioxidants (Basel), 2017 Nov 08; 6(4). PMID: 29112149    Free PMC article.
Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping.
Xiaofeng Dai, Hongye Cheng, Zhonghu Bai, Jia Li.
J Cancer, 2017 Nov 22; 8(16). PMID: 29158785    Free PMC article.
Highly Cited. Review.
Racial disparity in breast cancer: can it be mattered for prognosis and therapy.
Vijayalaxmi Gupta, Inamul Haque, +3 authors, Sushanta K Banerjee.
J Cell Commun Signal, 2017 Dec 01; 12(1). PMID: 29188479    Free PMC article.
The crossroads of breast cancer progression: insights into the modulation of major signaling pathways.
Fernando J Velloso, Arthur Fr Bianco, +8 authors, Ricardo G Correa.
Onco Targets Ther, 2017 Dec 05; 10. PMID: 29200866    Free PMC article.
Lymphovascular invasion as a negative prognostic factor for triple-negative breast cancer after surgery.
Ki Jung Ahn, Jisun Park, Yunseon Choi.
Radiat Oncol J, 2017 Dec 14; 35(4). PMID: 29232804    Free PMC article.
Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival.
Jessica Young, Tsutomu Kawaguchi, +3 authors, Kazuaki Takabe.
Oncotarget, 2017 Dec 17; 8(59). PMID: 29245954    Free PMC article.
Bioinformatics analysis of gene expression profiles to identify causal genes in luminal B2 breast cancer.
Jinguang Wang, Qi Du, Chen Li.
Oncol Lett, 2017 Dec 19; 14(6). PMID: 29250180    Free PMC article.
Type 2 Diabetes and Risk of Incident Cancer in China: A Prospective Study Among 0.5 Million Chinese Adults.
Xiong-Fei Pan, Meian He, +10 authors, China Kadoorie Biobank Collaborative Group.
Am J Epidemiol, 2018 Jan 06; 187(7). PMID: 29304221    Free PMC article.
Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis.
Huiyan Ma, Giske Ursin, +12 authors, Leslie Bernstein.
Breast Cancer Res, 2018 Jan 24; 20(1). PMID: 29357906    Free PMC article.
lncRNA Gene Signatures for Prediction of Breast Cancer Intrinsic Subtypes and Prognosis.
Silu Zhang, Junqing Wang, +4 authors, Yunyun Zhou.
Genes (Basel), 2018 Jan 27; 9(2). PMID: 29373522    Free PMC article.
Development of suspension cell culture model to mimic circulating tumor cells.
Ji Young Park, Ae Lee Jeong, +7 authors, Young Yang.
Oncotarget, 2018 Feb 09; 9(1). PMID: 29416640    Free PMC article.
Prognostic impact of AnxA1 and AnxA2 gene expression in triple-negative breast cancer.
Lee D Gibbs, Jamboor K Vishwanatha.
Oncotarget, 2018 Feb 09; 9(2). PMID: 29416802    Free PMC article.
RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment.
Kuo-Hua Lin, Ming-Yii Huang, +9 authors, Chia-Yang Li.
Sci Rep, 2018 Feb 10; 8(1). PMID: 29422643    Free PMC article.
Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges.
Ramesh Butti, Sumit Das, +3 authors, Gopal C Kundu.
Mol Cancer, 2018 Feb 20; 17(1). PMID: 29455658    Free PMC article.
A Metabolomic Approach to Predict Breast Cancer Behavior and Chemotherapy Response.
Marcella Regina Cardoso, Juliana Carvalho Santos, +3 authors, Sophie Françoise Mauricette Derchain.
Int J Mol Sci, 2018 Feb 22; 19(2). PMID: 29466297    Free PMC article.
EP4 as a Therapeutic Target for Aggressive Human Breast Cancer.
Mousumi Majumder, Pinki Nandi, +2 authors, Peeyush K Lala.
Int J Mol Sci, 2018 Mar 30; 19(4). PMID: 29596308    Free PMC article.
Expression and in vitro assessment of tumorigenicity for NOD1 and NOD2 receptors in breast cancer cell lines.
Fernando J Velloso, Mari Cleide Sogayar, Ricardo G Correa.
BMC Res Notes, 2018 Apr 05; 11(1). PMID: 29615116    Free PMC article.
The versatile nature of miR-9/9* in human cancer.
Katarzyna Nowek, Erik A C Wiemer, Mojca Jongen-Lavrencic.
Oncotarget, 2018 May 15; 9(29). PMID: 29755694    Free PMC article.
Targeting forkhead box M1 transcription factor in breast cancer.
Ruth M O'Regan, Rita Nahta.
Biochem Pharmacol, 2018 Jun 04; 154. PMID: 29859987    Free PMC article.
Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma.
Xuhui Guo, Juntao Li, +3 authors, Xudong Wei.
Med Sci Monit, 2018 Jun 04; 24. PMID: 29860265    Free PMC article.
The suppression of DUSP5 expression correlates with paclitaxel resistance and poor prognosis in basal-like breast cancer.
Tieju Liu, Huizhi Sun, +9 authors, Xiulan Zhao.
Int J Med Sci, 2018 Jun 19; 15(7). PMID: 29910679    Free PMC article.
A Similarity Regression Fusion Model for Integrating Multi-Omics Data to Identify Cancer Subtypes.
Yang Guo, Jianning Zheng, Xuequn Shang, Zhanhuai Li.
Genes (Basel), 2018 Jun 24; 9(7). PMID: 29933539    Free PMC article.
New developments in brain metastases.
Anna S Berghoff, Matthias Preusser.
Ther Adv Neurol Disord, 2018 Jul 24; 11. PMID: 30034538    Free PMC article.
Influence of age on radiomic features in 18F-FDG PET in normal breast tissue and in breast cancer tumors.
Sarah Boughdad, Christophe Nioche, +3 authors, Irène Buvat.
Oncotarget, 2018 Aug 17; 9(56). PMID: 30112113    Free PMC article.
Long Non-Coding RNAs as New Master Regulators of Resistance to Systemic Treatments in Breast Cancer.
Alma D Campos-Parra, Eduardo López-Urrutia, +5 authors, Carlos Pérez-Plasencia.
Int J Mol Sci, 2018 Sep 14; 19(9). PMID: 30208633    Free PMC article.
Design and Synthesis of New 1,3,5-Trisubstituted Triazines for the Treatment of Cancer and Inflammation.
Boulos Zacharie, Shaun D Abbott, +9 authors, Pierre Laurin.
ChemistryOpen, 2018 Sep 28; 7(9). PMID: 30258746    Free PMC article.
Emerging ways to treat breast cancer: will promises be met?
Pouria Samadi, Sahar Saki, +2 authors, Massoud Saidijam.
Cell Oncol (Dordr), 2018 Sep 28; 41(6). PMID: 30259416
Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.
Yun Zhang, Shunbin Xiong, +9 authors, Guillermina Lozano.
Nat Commun, 2018 Sep 29; 9(1). PMID: 30262850    Free PMC article.
ZBTB7A governs estrogen receptor alpha expression in breast cancer.
Mary Ellen Molloy, Monika Lewinska, +7 authors, Zhi-Min Yuan.
J Mol Cell Biol, 2018 Sep 29; 10(4). PMID: 30265334    Free PMC article.
ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer.
Sushil Kumar, David W Wilkes, +7 authors, Rumela Chakrabarti.
J Clin Invest, 2018 Oct 09; 128(11). PMID: 30295647    Free PMC article.
Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression.
Colt A Egelston, Christian Avalos, +9 authors, Peter P Lee.
Nat Commun, 2018 Oct 18; 9(1). PMID: 30327458    Free PMC article.
Deblender: a semi-/unsupervised multi-operational computational method for complete deconvolution of expression data from heterogeneous samples.
Konstantina Dimitrakopoulou, Elisabeth Wik, Lars A Akslen, Inge Jonassen.
BMC Bioinformatics, 2018 Nov 09; 19(1). PMID: 30404611    Free PMC article.
Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy.
Wataru Goto, Shinichiro Kashiwagi, +7 authors, Masaichi Ohira.
J Transl Med, 2018 Nov 11; 16(1). PMID: 30413161    Free PMC article.
Association between MRI background parenchymal enhancement and lymphovascular invasion and estrogen receptor status in invasive breast cancer.
Jun Li, Yin Mo, +6 authors, Ying Yang.
Br J Radiol, 2019 Aug 10; 92(1103). PMID: 31398071    Free PMC article.
Integrated network analysis identifies hsa-miR-4756-3p as a regulator of FOXM1 in Triple Negative Breast Cancer.
Yuanliang Gu, Wenjuan Wang, +3 authors, Peng Shu.
Sci Rep, 2019 Sep 27; 9(1). PMID: 31554904    Free PMC article.
Genetic interactions between ANLN and KDR are prognostic for breast cancer survival.
Xiaofeng Dai, Xiao Chen, Olivier Hakizimana, Yi Mei.
Oncol Rep, 2019 Oct 04; 42(6). PMID: 31578580    Free PMC article.
Role of miR-10b-5p in the prognosis of breast cancer.
Junmin Wang, Yanyun Yan, Zhiqi Zhang, Yali Li.
PeerJ, 2019 Oct 04; 7. PMID: 31579605    Free PMC article.
A Review on Mammary Tumors in Rabbits: Translation of Pathology into Medical Care.
Sandra Schöniger, Sophie Degner, Bharat Jasani, Heinz-Adolf Schoon.
Animals (Basel), 2019 Oct 05; 9(10). PMID: 31581718    Free PMC article.
Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells.
Fujun Li, Lixia Miao, +6 authors, Xuesen Zhang.
J Exp Clin Cancer Res, 2019 Oct 12; 38(1). PMID: 31601253    Free PMC article.
Treatment of Breast Cancer With Gonadotropin-Releasing Hormone Analogs.
Maira Huerta-Reyes, Guadalupe Maya-Núñez, +4 authors, Arturo Aguilar-Rojas.
Front Oncol, 2019 Oct 22; 9. PMID: 31632902    Free PMC article.
A hierarchical integration deep flexible neural forest framework for cancer subtype classification by integrating multi-omics data.
Jing Xu, Peng Wu, +3 authors, Hassan Dawood.
BMC Bioinformatics, 2019 Oct 30; 20(1). PMID: 31660856    Free PMC article.
Recent advances in nanotheranostics for triple negative breast cancer treatment.
Vikram Thakur, Rajaletchumy Veloo Kutty.
J Exp Clin Cancer Res, 2019 Oct 30; 38(1). PMID: 31661003    Free PMC article.
Night-shift work and risk of breast cancer in Korean women.
Thu-Thi Pham, Minji Hwang, +7 authors, Boyoung Park.
Clin Epidemiol, 2019 Nov 07; 11. PMID: 31686916    Free PMC article.
DNA methylation profiles capturing breast cancer heterogeneity.
Xiao Chen, Jianying Zhang, Xiaofeng Dai.
BMC Genomics, 2019 Nov 09; 20(1). PMID: 31699026    Free PMC article.
Digitaldlsorter: Deep-Learning on scRNA-Seq to Deconvolute Gene Expression Data.
Carlos Torroja, Fatima Sanchez-Cabo.
Front Genet, 2019 Nov 12; 10. PMID: 31708961    Free PMC article.
FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control.
Xiaofeng Dai, Shuo Zhang, +3 authors, Zhaohui Huang.
Front Oncol, 2019 Nov 12; 9. PMID: 31709178    Free PMC article.
Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology.
Rinku Dutta, Roukiah Khalil, +2 authors, Subhra Mohapatra.
Int J Mol Sci, 2019 Nov 17; 20(21). PMID: 31731424    Free PMC article.
Clinical Implications of Tumor-Infiltrating Immune Cells in Breast Cancer.
Shi-Chao Zhang, Zu-Quan Hu, +6 authors, Zhu Zeng.
J Cancer, 2019 Nov 26; 10(24). PMID: 31762828    Free PMC article.
Functional impact of the long non-coding RNA MEG3 deletion by CRISPR/Cas9 in the human triple negative metastatic Hs578T cancer cell line.
Carlos Deocesano-Pereira, Raquel Arminda Carvalho Machado, +4 authors, Mari Cleide Sogayar.
Oncol Lett, 2019 Dec 04; 18(6). PMID: 31788068    Free PMC article.
Identification of Breast Cancer Subtype Specific MicroRNAs Using Survival Analysis to Find Their Role in Transcriptomic Regulation.
Michał Denkiewicz, Indrajit Saha, +2 authors, Dariusz Plewczynski.
Front Genet, 2019 Dec 05; 10. PMID: 31798622    Free PMC article.
A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis.
Menghan Wang, Tianxin Yu, +6 authors, Chi Wang.
BMC Bioinformatics, 2019 Dec 04; 20(1). PMID: 31791231    Free PMC article.
Inhibitory Effects of Osthole on Human Breast Cancer Cell Progression via Induction of Cell Cycle Arrest, Mitochondrial Dysfunction, and ER Stress.
Wonhyoung Park, Sunwoo Park, Gwonhwa Song, Whasun Lim.
Nutrients, 2019 Nov 17; 11(11). PMID: 31731635    Free PMC article.
Long Non-Coding RNA: Dual Effects on Breast Cancer Metastasis and Clinical Applications.
Qi-Yuan Huang, Guo-Feng Liu, +3 authors, Li-Xia Xiong.
Cancers (Basel), 2019 Nov 21; 11(11). PMID: 31744046    Free PMC article.
Subtype specific targeting of calcium signaling in breast cancer.
Monish Ram Makena, Rajini Rao.
Cell Calcium, 2019 Nov 30; 85. PMID: 31783287    Free PMC article.
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.
Michael J Lukey, Ahmad A Cluntun, +9 authors, Richard A Cerione.
Cell Rep, 2019 Oct 03; 29(1). PMID: 31577957    Free PMC article.
Thioalbamide, A Thioamidated Peptide from Amycolatopsis alba, Affects Tumor Growth and Stemness by Inducing Metabolic Dysfunction and Oxidative Stress.
Luca Frattaruolo, Marco Fiorillo, +7 authors, Anna Rita Cappello.
Cells, 2019 Nov 14; 8(11). PMID: 31717378    Free PMC article.
Expression profile of Toll‑like receptors in human breast cancer.
Shuxun Shi, Cong Xu, +4 authors, Guiwen Yang.
Mol Med Rep, 2019 Dec 04; 21(2). PMID: 31789409    Free PMC article.
Reprogramming of fatty acid metabolism in cancer.
Nikos Koundouros, George Poulogiannis.
Br J Cancer, 2019 Dec 11; 122(1). PMID: 31819192    Free PMC article.
Modulating cancer stemness provides luminal a breast cancer cells with HER2 positive-like features.
Yi Mei, Dongyan Cai, Xiaofeng Dai.
J Cancer, 2020 Jan 21; 11(5). PMID: 31956362    Free PMC article.
Anticancer Ruthenium(III) Complexes and Ru(III)-Containing Nanoformulations: An Update on the Mechanism of Action and Biological Activity.
Claudia Riccardi, Domenica Musumeci, +3 authors, Daniela Montesarchio.
Pharmaceuticals (Basel), 2019 Sep 29; 12(4). PMID: 31561546    Free PMC article.
Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype.
Xiao-Qiong Chen, Fan Zhang, +3 authors, Yu Peng.
Clin Epigenetics, 2020 Jan 22; 12(1). PMID: 31959227    Free PMC article.
The long non-coding RNA DANCR regulates the inflammatory phenotype of breast cancer cells and promotes breast cancer progression via EZH2-dependent suppression of SOCS3 transcription.
Ke-Jing Zhang, Xiao-Lang Tan, Lei Guo.
Mol Oncol, 2019 Dec 21; 14(2). PMID: 31860165    Free PMC article.
Establishment and Characterization of a New Triple Negative Breast Cancer Cell Line from an Iranian Breast Cancer Tissue.
Farzaneh Ghaderi, Fereshteh Mehdipour, +2 authors, Abbas Ghaderi.
Asian Pac J Cancer Prev, 2019 Jun 28; 20(6). PMID: 31244288    Free PMC article.
Spatially multiplexed RNA in situ hybridization to reveal tumor heterogeneity.
Lena Voith von Voithenberg, Anna Fomitcheva Khartchenko, +2 authors, Govind V Kaigala.
Nucleic Acids Res, 2019 Dec 20; 48(3). PMID: 31853536    Free PMC article.
DeepTRIAGE: interpretable and individualised biomarker scores using attention mechanism for the classification of breast cancer sub-types.
Adham Beykikhoshk, Thomas P Quinn, +2 authors, Svetha Venkatesh.
BMC Med Genomics, 2020 Feb 26; 13(Suppl 3). PMID: 32093737    Free PMC article.
MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer.
Begoña Alday-Parejo, François Richard, +5 authors, Curzio Rüegg.
Cancers (Basel), 2020 Jan 23; 12(1). PMID: 31963297    Free PMC article.
Comprehensive analysis of the GATA transcription factor gene family in breast carcinoma using gene microarrays, online databases and integrated bioinformatics.
Shan Yu, Xuepeng Jiang, +6 authors, Baoliang Guo.
Sci Rep, 2019 Mar 16; 9(1). PMID: 30872657    Free PMC article.
Association of white blood cell count with breast cancer burden varies according to menopausal status, body mass index, and hormone receptor status: a case-control study.
Byoungjin Park, Hye Sun Lee, Ji Won Lee, Seho Park.
Sci Rep, 2019 Apr 10; 9(1). PMID: 30962496    Free PMC article.
Exploring cellular uptake, accumulation and mechanism of action of a cationic Ru-based nanosystem in human preclinical models of breast cancer.
Marialuisa Piccolo, Gabriella Misso, +12 authors, Rita Santamaria.
Sci Rep, 2019 May 09; 9(1). PMID: 31065032    Free PMC article.
Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively.
Mauro Sola-Penna, Larissa P Paixão, +8 authors, Patricia Zancan.
Br J Cancer, 2019 Dec 11; 122(2). PMID: 31819176    Free PMC article.
Joint skeleton estimation of multiple directed acyclic graphs for heterogeneous population.
Jianyu Liu, Wei Sun, Yufeng Liu.
Biometrics, 2018 Aug 07; 75(1). PMID: 30081434    Free PMC article.
DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.
Feda H Hamdan, Steven A Johnsen.
Proc Natl Acad Sci U S A, 2018 Dec 14; 115(52). PMID: 30541891    Free PMC article.
Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas.
S R Rosario, M D Long, +3 authors, D J Smiraglia.
Nat Commun, 2018 Dec 16; 9(1). PMID: 30552315    Free PMC article.
Highly Cited.
Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patients.
Solmaz Khalighfard, Ali Mohammad Alizadeh, Shiva Irani, Ramesh Omranipour.
Sci Rep, 2018 Dec 21; 8(1). PMID: 30568292    Free PMC article.
The combined survival effect of codon 72 polymorphisms and p53 somatic mutations in breast cancer depends on race and molecular subtype.
Shantel Hebert-Magee, Han Yu, +6 authors, Upender Manne.
PLoS One, 2019 Feb 08; 14(2). PMID: 30730944    Free PMC article.
Circulating tumor DNA dynamics using patient-customized assays are associated with outcome in neoadjuvantly treated breast cancer.
Timothy M Butler, Christopher T Boniface, +6 authors, Paul T Spellman.
Cold Spring Harb Mol Case Stud, 2019 Mar 06; 5(2). PMID: 30833418    Free PMC article.
Classifying Breast Cancer Subtypes Using Multiple Kernel Learning Based on Omics Data.
Mingxin Tao, Tianci Song, +5 authors, Zekun Yang.
Genes (Basel), 2019 Mar 15; 10(3). PMID: 30866472    Free PMC article.
Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.
A J Fritz, N E Gillis, +19 authors, G S Stein.
Genes Chromosomes Cancer, 2019 Mar 16; 58(7). PMID: 30873710    Free PMC article.
BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells.
Xiaowen Zhang, Yao Wang, +7 authors, Rong Li.
Breast Cancer Res, 2019 Apr 19; 21(1). PMID: 30995943    Free PMC article.
Fulvestrant in the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: A review.
Junjie Li, Zhonghua Wang, Zhimin Shao.
Cancer Med, 2019 Apr 21; 8(5). PMID: 31004402    Free PMC article.
Decoding the link between WWOX and p53 in aggressive breast cancer.
Suhaib K Abdeen, Rami I Aqeilan.
Cell Cycle, 2019 May 11; 18(11). PMID: 31075076    Free PMC article.
The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
Joana Sales-Dias, Gabriela Silva, +2 authors, Ana Barbas.
PLoS One, 2019 May 21; 14(5). PMID: 31107884    Free PMC article.
Reclassification of breast cancer: Towards improved diagnosis and outcome.
Alexander P Landry, Zsolt Zador, Rashida Haq, Michael D Cusimano.
PLoS One, 2019 May 23; 14(5). PMID: 31116801    Free PMC article.
Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer.
Roberta Noberini, Camilla Restellini, +15 authors, Tiziana Bonaldi.
Cancers (Basel), 2019 May 30; 11(5). PMID: 31137727    Free PMC article.
Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs.
Simona Punzi, Marine Meliksetian, +11 authors, Luisa Lanfrancone.
Cells, 2019 Jun 21; 8(6). PMID: 31216647    Free PMC article.
CONFIGURE: A pipeline for identifying context specific regulatory modules from gene expression data and its application to breast cancer.
Sungjoon Park, Doyeong Hwang, +2 authors, Jaewoo Kang.
BMC Med Genomics, 2019 Jul 13; 12(Suppl 5). PMID: 31296219    Free PMC article.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
K Yu, B Chen, +7 authors, M Sirota.
Nat Commun, 2019 Aug 10; 10(1). PMID: 31395879    Free PMC article.
Up-regulation of SPC25 promotes breast cancer.
Qian Wang, Yanhui Zhu, +5 authors, Xiufeng Cao.
Aging (Albany NY), 2019 Aug 11; 11(15). PMID: 31400751    Free PMC article.
Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.
Stamatia Rontogianni, Eleni Synadaki, +5 authors, Maarten Altelaar.
Commun Biol, 2019 Sep 12; 2. PMID: 31508500    Free PMC article.
Short-Term Microgravity Influences Cell Adhesion in Human Breast Cancer Cells.
Mohamed Zakaria Nassef, Sascha Kopp, +9 authors, Daniela Grimm.
Int J Mol Sci, 2019 Nov 17; 20(22). PMID: 31731625    Free PMC article.
Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy.
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, +4 authors, Seema Singh.
Ann Transl Med, 2019 Dec 07; 7(20). PMID: 31807574    Free PMC article.
Claudin-1, A Double-Edged Sword in Cancer.
Ajaz A Bhat, Najeeb Syed, +15 authors, Mohammad Haris.
Int J Mol Sci, 2020 Jan 19; 21(2). PMID: 31952355    Free PMC article.
NEAT1: A novel cancer-related long non-coding RNA.
Xin Yu, Zheng Li, +2 authors, William Ka Kei Wu.
Cell Prolif, 2017 Jan 21; 50(2). PMID: 28105699    Free PMC article.
Highly Cited. Review.
Tumour biomarkers-Tracing the molecular function and clinical implication.
Jiahao Lin, Lie Ma, +4 authors, Degui Lin.
Cell Prolif, 2019 Mar 16; 52(3). PMID: 30873683    Free PMC article.
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis.
Carmen Elena Condrat, Dana Claudia Thompson, +6 authors, Silviu Cristian Voinea.
Cells, 2020 Jan 26; 9(2). PMID: 31979244    Free PMC article.
Structure-Activity Relationship of HER2 Receptor Targeting Peptide and Its Derivatives in Targeted Tumor Therapy.
Beáta Biri-Kovács, Afrodité Adorján, +3 authors, Gábor Mező.
Biomolecules, 2020 Jan 30; 10(2). PMID: 31991749    Free PMC article.
A Post-Processing Algorithm for miRNA Microarray Data.
Stepan Nersisyan, Maxim Shkurnikov, +4 authors, Alexander Tonevitsky.
Int J Mol Sci, 2020 Feb 16; 21(4). PMID: 32059403    Free PMC article.
A mouse model of chemotherapy-related cognitive impairments integrating the risk factors of aging and APOE4 genotype.
Tamar C Demby, Olga Rodriguez, +4 authors, G William Rebeck.
Behav Brain Res, 2020 Feb 07; 384. PMID: 32027870    Free PMC article.
Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients.
Rosa Porzio, Claudia Cordini, +5 authors, Luigi Cavanna.
Oncol Lett, 2020 Mar 21; 19(3). PMID: 32194754    Free PMC article.
Analysis Natrium Iodide Symporter Expression in Breast Cancer Subtypes for Radioiodine Therapy Response.
Aisyah Elliyanti, Dewi Rusnita, +4 authors, Wirsma Arif Harahap.
Nucl Med Mol Imaging, 2020 Mar 25; 54(1). PMID: 32206129    Free PMC article.
Performance Characteristics of the BluePrint® Breast Cancer Diagnostic Test.
Lorenza Mittempergher, Leonie Jmj Delahaye, +7 authors, Annuska M Glas. Electronic address:
Transl Oncol, 2020 Mar 26; 13(4). PMID: 32208353    Free PMC article.
Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies.
Mauricio A Medina, Goldie Oza, +4 authors, Jose Tapia Ramirez.
Int J Environ Res Public Health, 2020 Apr 05; 17(6). PMID: 32245065    Free PMC article.
The LncRNA HOTAIRM1 Promotes Tamoxifen Resistance by Mediating HOXA1 Expression in ER+ Breast Cancer Cells.
Clara Yuri Kim, Ji Hoon Oh, Ji-Yeon Lee, Myoung Hee Kim.
J Cancer, 2020 Apr 15; 11(12). PMID: 32284737    Free PMC article.
Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer: A Health Technology Assessment.
Ontario Health (Quality).
Ont Health Technol Assess Ser, 2020 Apr 15; 20(10). PMID: 32284770    Free PMC article.
DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cells.
Nam Ji Sung, Na Hui Kim, +2 authors, Sin-Aye Park.
Biosci Rep, 2020 Mar 07; 40(3). PMID: 32141512    Free PMC article.
Restructured society and environment: A review on potential technological strategies to control the COVID-19 pandemic.
Rajvikram Madurai Elavarasan, Rishi Pugazhendhi.
Sci Total Environ, 2020 Apr 28; 725. PMID: 32336562    Free PMC article.
The trastuzumab era: current and upcoming targeted HER2+ breast cancer therapies.
Jordyn Kreutzfeldt, Brett Rozeboom, Nandini Dey, Pradip De.
Am J Cancer Res, 2020 May 06; 10(4). PMID: 32368385    Free PMC article.
Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis.
Li-Feng Yang, Fan Yang, +5 authors, Da-Qiang Li.
Theranostics, 2020 May 07; 10(12). PMID: 32373210    Free PMC article.
Expression of Tumour-Associated MUC1 Is a Poor Prognostic Marker in Breast Cancer in Kumasi, Ghana.
E Atta Manu, K Bedu-Addo, +3 authors, B M Duduyemi.
J Oncol, 2020 May 08; 2020. PMID: 32377198    Free PMC article.
Prognostic Role of Androgen Receptor Expression in Surgically Resected Early Breast Cancer Patients.
Yaewon Yang, Ahrum Min, +11 authors, Seock-Ah Im.
J Breast Cancer, 2020 May 13; 23(2). PMID: 32395377    Free PMC article.
Circadian oscillations persist in low malignancy breast cancer cells.
Sujeewa S Lellupitiyage Don, Hui-Hsien Lin, +3 authors, Michelle E Farkas.
Cell Cycle, 2019 Jul 31; 18(19). PMID: 31357909    Free PMC article.
Extracellular Acidosis Promotes Metastatic Potency via Decrease of the BMAL1 Circadian Clock Gene in Breast Cancer.
Yong-Jin Kwon, Eun-Bi Seo, +8 authors, Sang-Kyu Ye.
Cells, 2020 Apr 23; 9(4). PMID: 32316196    Free PMC article.
AR/ER Ratio Correlates with Expression of Proliferation Markers and with Distinct Subset of Breast Tumors.
Nelson Rangel, Milena Rondon-Lagos, +4 authors, Isabella Castellano.
Cells, 2020 Apr 30; 9(4). PMID: 32344660    Free PMC article.
Hormone receptor expression correlates with EGFR gene mutation in lung cancer in patients with simultaneous primary breast cancer.
Zhihuang Hu, Xuan Zou, +7 authors, Jianhua Chang.
Transl Lung Cancer Res, 2020 May 19; 9(2). PMID: 32420072    Free PMC article.
Assessing the Role of the Interleukin-12/STAT4 Axis in Breast Cancer by a Bioinformatics Approach.
Angel Núñez-Marrero.
Int J Sci Basic Appl Res, 2019 Jan 01; 48(2). PMID: 32467824    Free PMC article.
A population-based analysis of breast cancer incidence and survival by subtype in Ontario women.
S J Seung, A N Traore, +3 authors, K J Jerzak.
Curr Oncol, 2020 Jun 04; 27(2). PMID: 32489268    Free PMC article.
Prognostic gene expression signature revealed the involvement of mutational pathways in cancer genome.
Hongde Liu, Huamei Li, +2 authors, Xiao Sun.
J Cancer, 2020 Jun 04; 11(15). PMID: 32489468    Free PMC article.
The prognostic value of microRNA-biogenesis genes Argonaute 1 and 2 variants in breast cancer patients.
Manal S Fawzy, Eman A Toraih, +3 authors, Ranya Hassan.
Am J Transl Res, 2020 Jun 09; 12(5). PMID: 32509194    Free PMC article.
Exomes of Ductal Luminal Breast Cancer Patients from Southwest Colombia: Gene Mutational Profile and Related Expression Alterations.
Carolina Cortes-Urrea, Fernando Bueno-Gutiérrez, +8 authors, Javier De Las Rivas.
Biomolecules, 2020 May 06; 10(5). PMID: 32365829    Free PMC article.
Tumor-Infiltrating CD8 T Cells Predict Clinical Breast Cancer Outcomes in Young Women.
Yong Won Jin, Pingzhao Hu.
Cancers (Basel), 2020 May 03; 12(5). PMID: 32357420    Free PMC article.
Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer.
Gagan Gupta, Caroline Dasom Lee, +10 authors, Amy H Tang.
Ann Breast Cancer Ther, 2020 Jun 17; 4(1). PMID: 32542231    Free PMC article.
Hormone Receptor-Status Prediction in Breast Cancer Using Gene Expression Profiles and Their Macroscopic Landscape.
Seokhyun Yoon, Hye Sung Won, +3 authors, Yoon Ho Ko.
Cancers (Basel), 2020 May 10; 12(5). PMID: 32380759    Free PMC article.
Serum amyloid A predisposes inflammatory tumor microenvironment in triple negative breast cancer.
Rosa Mistica C Ignacio, Carla R Gibbs, +3 authors, Deok-Soo Son.
Oncotarget, 2019 Feb 08; 10(4). PMID: 30728901    Free PMC article.
Phytochemical profile and antiproliferative effect of Ficus crocata extracts on triple-negative breast cancer cells.
Carlos A Sánchez-Valdeolívar, Patricia Alvarez-Fitz, +10 authors, Miguel A Mendoza-Catalán.
BMC Complement Med Ther, 2020 Jun 24; 20(1). PMID: 32571387    Free PMC article.
Global View of Candidate Therapeutic Target Genes in Hormone-Responsive Breast Cancer.
Annamaria Salvati, Valerio Gigantino, +8 authors, Giorgio Giurato.
Int J Mol Sci, 2020 Jun 11; 21(11). PMID: 32517194    Free PMC article.
Differential Glucocorticoid-Dependent Regulation and Function of the ERRFI1 Gene in Triple-Negative Breast Cancer.
Chromewell Agustin R Mojica, Weand S Ybañez, +2 authors, Pia D Bagamasbad.
Endocrinology, 2020 May 21; 161(7). PMID: 32432675    Free PMC article.
Intratumoral Heterogeneity of Expression of 16 miRNA in Luminal Cancer of the Mammary Gland.
Yuliya A Veryaskina, Sergei E Titov, +2 authors, Igor F Zhimulev.
Noncoding RNA, 2020 May 15; 6(2). PMID: 32403384    Free PMC article.
Molecular Cytogenomic Characterization of the Murine Breast Cancer Cell Lines C-127I, EMT6/P and TA3 Hauschka.
Shaymaa Azawi, Thomas Liehr, Martina Rincic, Mattia Manferrari.
Int J Mol Sci, 2020 Jul 08; 21(13). PMID: 32630352    Free PMC article.
Effect of neoadjuvant therapy on breast cancer biomarker profile.
Laura Rey-Vargas, Juan Carlos Mejía-Henao, María Carolina Sanabria-Salas, Silvia J Serrano-Gomez.
BMC Cancer, 2020 Jul 20; 20(1). PMID: 32682413    Free PMC article.
Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer.
Samarth Kansara, Vijay Pandey, +3 authors, Amit Kumar Pandey.
Cells, 2020 Jun 25; 9(6). PMID: 32575858    Free PMC article.
Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on Breast Cancer Cells.
Valarmathy Murugaiah, Chiara Agostinis, +10 authors, Uday Kishore.
Front Immunol, 2020 Aug 01; 11. PMID: 32733438    Free PMC article.
Evaluation of the TRPM protein family as potential biomarkers for various types of human cancer using public database analyses.
Fuchuang Qin, Lingdi Lao, +4 authors, Jianping Zeng.
Exp Ther Med, 2020 Aug 04; 20(2). PMID: 32742323    Free PMC article.
miR-622 is a novel potential biomarker of breast carcinoma and impairs motility of breast cancer cells through targeting NUAK1 kinase.
Francesca Maria Orlandella, Raffaela Mariarosaria Mariniello, +11 authors, Giuliana Salvatore.
Br J Cancer, 2020 May 19; 123(3). PMID: 32418991    Free PMC article.
Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer.
Chengli Lu, Zhiyuan Ma, +4 authors, Taolang Li.
Cancer Cell Int, 2020 Aug 13; 20. PMID: 32782435    Free PMC article.
Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification.
Alejandro Lopez-Rincon, Lucero Mendoza-Maldonado, +4 authors, Alberto Tonda.
Cancers (Basel), 2020 Jul 09; 12(7). PMID: 32635415    Free PMC article.
Machine learning for RNA sequencing-based intrinsic subtyping of breast cancer.
Silvia Cascianelli, Ivan Molineris, +2 authors, Enzo Medico.
Sci Rep, 2020 Aug 23; 10(1). PMID: 32826944    Free PMC article.
Comparative Analysis of the Development of Acquired Radioresistance in Canine and Human Mammary Cancer Cell Lines.
Mark Gray, Arran K Turnbull, +4 authors, David J Argyle.
Front Vet Sci, 2020 Aug 28; 7. PMID: 32851022    Free PMC article.
Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer.
Elizabeth Varghese, Samson Mathews Samuel, +3 authors, Dietrich Büsselberg.
Cancers (Basel), 2020 Aug 19; 12(8). PMID: 32806533    Free PMC article.
Analysis of Circulating Tumor DNA to Predict Neoadjuvant Therapy Effectiveness and Breast Cancer Recurrence.
Shuai Hao, Wuguo Tian, +5 authors, Donglin Luo.
J Breast Cancer, 2020 Sep 11; 23(4). PMID: 32908788    Free PMC article.
Silencing of Nucleostemin by siRNA Induces Apoptosis in MCF-7 and MDA-MB-468 Cell Lines.
Mahdiyeh Moudi, Ramin Saravani, Saman Sargazi.
Iran J Pharm Res, 2020 Sep 15; 19(1). PMID: 32922467    Free PMC article.
SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women.
Angel Núñez-Marrero, Nelly Arroyo, +3 authors, Julie Dutil.
Oncotarget, 2020 Sep 26; 11(37). PMID: 32973967    Free PMC article.
Peptidylarginine deiminase 4 overexpression resensitizes MCF-7/ADR breast cancer cells to adriamycin via GSK3β/p53 activation.
Qianqian Zhou, Chao Song, +3 authors, Xuesen Zhang.
Cancer Manag Res, 2019 Jan 23; 11. PMID: 30666159    Free PMC article.
Profiling of Invasive Breast Carcinoma Circulating Tumour Cells-Are We Ready for the 'Liquid' Revolution?
Marcin Braun, Aleksandra Markiewicz, +2 authors, Hanna Romańska.
Cancers (Basel), 2019 Jan 30; 11(2). PMID: 30691008    Free PMC article.
The onus of cannabinoids in interrupting the molecular odyssey of breast cancer: A critical perspective on UPRER and beyond.
Safikur Rahman, Ayyagari Archana, +4 authors, Rinki Minakshi.
Saudi Pharm J, 2019 Apr 13; 27(3). PMID: 30976189    Free PMC article.
Flavonoids: New Frontier for Immuno-Regulation and Breast Cancer Control.
Meenakshi Sudhakaran, Sagar Sardesai, Andrea I Doseff.
Antioxidants (Basel), 2019 Apr 19; 8(4). PMID: 30995775    Free PMC article.
Genomic Profiling of the Steroidogenic Acute Regulatory Protein in Breast Cancer: In Silico Assessments and a Mechanistic Perspective.
Pulak R Manna, Ahsen U Ahmed, +4 authors, Kevin Pruitt.
Cancers (Basel), 2019 May 08; 11(5). PMID: 31060224    Free PMC article.
Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer.
Rasha M Sareyeldin, Ishita Gupta, +4 authors, Ala-Eddin Al Moustafa.
Cancers (Basel), 2019 May 15; 11(5). PMID: 31083383    Free PMC article.
A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.
Richard D A Wilkinson, Roberta E Burden, +10 authors, Christopher J Scott.
J Oncol, 2019 Jul 28; 2019. PMID: 31346333    Free PMC article.
MicroRNAs involved in drug resistance of breast cancer by regulating autophagy.
Nan Wen, Qing Lv, Zheng-Gui Du.
J Zhejiang Univ Sci B, 2020 Sep 08; 21(9). PMID: 32893526    Free PMC article.
Deep Learning to Estimate Human Epidermal Growth Factor Receptor 2 Status from Hematoxylin and Eosin-Stained Breast Tissue Images.
Deepak Anand, Nikhil Cherian Kurian, +4 authors, Amit Sethi.
J Pathol Inform, 2020 Oct 10; 11. PMID: 33033656    Free PMC article.
Treatment effect of palbociclib plus endocrine therapy by prognostic and intrinsic subtype and biomarker analysis in patients with bone-only disease: a joint analysis of PALOMA-2 and PALOMA-3 clinical trials.
Richard S Finn, Massimo Cristofanilli, +11 authors, Hope S Rugo.
Breast Cancer Res Treat, 2020 Aug 13; 184(1). PMID: 32783178    Free PMC article.
Breast Cancer Cells in Microgravity: New Aspects for Cancer Research.
Mohamed Zakaria Nassef, Daniela Melnik, +7 authors, Marcus Krüger.
Int J Mol Sci, 2020 Oct 09; 21(19). PMID: 33027908    Free PMC article.
Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer.
Simone Borgoni, Emre Sofyalı, +11 authors, Stefan Wiemann.
Cancers (Basel), 2020 Oct 15; 12(10). PMID: 33050633    Free PMC article.
RNA-Seq-Based Breast Cancer Subtypes Classification Using Machine Learning Approaches.
Zhezhou Yu, Zhuo Wang, Xiangchun Yu, Zhe Zhang.
Comput Intell Neurosci, 2020 Nov 13; 2020. PMID: 33178256    Free PMC article.
Mitochondrial DNA Mutation Analysis in Breast Cancer: Shifting From Germline Heteroplasmy Toward Homoplasmy in Tumors.
Carlos Jhovani Pérez-Amado, Hugo Tovar, +8 authors, Silvia Jiménez-Morales.
Front Oncol, 2020 Nov 17; 10. PMID: 33194675    Free PMC article.
Molecular "omic" signatures in systemic sclerosis.
Bhaven K Mehta, Monica E Espinoza, Monique Hinchcliff, Michael L Whitfield.
Eur J Rheumatol, 2020 Nov 10; 7(Suppl 3). PMID: 33164732    Free PMC article.
Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of N-(3-Hydroxyindole)-Appended β-Carbolines/Tetrahydro-β-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer.
Bharvi Sharma, Sourav Taru Saha, +5 authors, Vipan Kumar.
ACS Omega, 2020 Nov 24; 5(45). PMID: 33225121    Free PMC article.
Vascular endothelial growth factor encoded by Parapoxviruses can regulate metabolism and survival of triple negative breast cancer cells.
Dipayan Bose, Sagarika Banerjee, +2 authors, Erle S Robertson.
Cell Death Dis, 2020 Nov 22; 11(11). PMID: 33219203    Free PMC article.
Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition.
Claudia Riccardi, Ettore Napolitano, Domenica Musumeci, Daniela Montesarchio.
Molecules, 2020 Nov 14; 25(22). PMID: 33182593    Free PMC article.
HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes.
Vic Hart, Hannah Gautrey, John Kirby, Alison Tyson-Capper.
Oncotarget, 2020 Nov 28; 11(46). PMID: 33245725    Free PMC article.
Use of trastuzumab as an adjuvant/neoadjuvant therapy in patients with HER2-positive breast cancer in China: The Nvwa study.
Junjie Li, Zhimin Shao, +8 authors, Ziwei Ying.
Medicine (Baltimore), 2018 May 26; 97(21). PMID: 29794725    Free PMC article.
Proteome profiling of triple negative breast cancer cells overexpressing NOD1 and NOD2 receptors unveils molecular signatures of malignant cell proliferation.
Fernando J Velloso, Alexandre R Campos, Mari C Sogayar, Ricardo G Correa.
BMC Genomics, 2019 Feb 23; 20(1). PMID: 30791886    Free PMC article.
CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells.
Divya Ganapathi Sankaran, Alexander J Stemm-Wolf, Chad G Pearson.
Mol Biol Cell, 2019 Feb 28; 30(10). PMID: 30811267    Free PMC article.
Importance of CD45RO+ tumor-infiltrating lymphocytes in post-operative survival of breast cancer patients.
Simin Ahmadvand, Zahra Faghih, +6 authors, Abbas Ghaderi.
Cell Oncol (Dordr), 2019 Mar 03; 42(3). PMID: 30825183
Intrabeam Radiation Inhibits Proliferation, Migration, and Invasiveness and Promotes Apoptosis of MCF-7 Breast Cancer Cells.
Lingxiao Pan, Minghui Wan, +5 authors, Changsheng Ye.
Technol Cancer Res Treat, 2019 Apr 02; 18. PMID: 30929609    Free PMC article.
FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.
Lana McClements, Stephanie Annett, +11 authors, Tracy Robson.
BMC Cancer, 2019 Apr 13; 19(1). PMID: 30975104    Free PMC article.
Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells.
Irma B Mitre-Aguilar, Tonatiuh Barrios-Garcia, +10 authors, Alejandro Zentella-Dehesa.
BMC Cancer, 2019 Apr 17; 19(1). PMID: 30987626    Free PMC article.
Development and characterisation of acquired radioresistant breast cancer cell lines.
Mark Gray, Arran K Turnbull, +8 authors, David Argyle.
Radiat Oncol, 2019 Apr 17; 14(1). PMID: 30987655    Free PMC article.
Efficacy of an RNA-based multigene assay with core needle biopsy samples for risk evaluation in hormone-positive early breast cancer.
Jeeyeon Lee, Eun Hye Lee, +9 authors, Jin Hyang Jung.
BMC Cancer, 2019 Apr 27; 19(1). PMID: 31023265    Free PMC article.
Pectoral nerve block in anesthesia for modified radical mastectomy: A meta-analysis based on randomized controlled trials.
Jia Zhao, Fanglei Han, +2 authors, Zinan Li.
Medicine (Baltimore), 2019 May 03; 98(18). PMID: 31045802    Free PMC article.
FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors - implications for therapy of luminal breast cancer.
Dominika Piasecka, Marcin Braun, +4 authors, Hanna Romanska.
J Exp Clin Cancer Res, 2019 May 31; 38(1). PMID: 31142340    Free PMC article.
IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission.
Pantong Li, Yu Liu, +13 authors, Yu Zhao.
Int J Oncol, 2019 Jun 08; 55(2). PMID: 31173174    Free PMC article.
APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC.
Matilde Clarissa Malfatti, Lorenzo Gerratana, +5 authors, Gianluca Tell.
J Exp Clin Cancer Res, 2019 Jul 17; 38(1). PMID: 31307523    Free PMC article.
Additive Pharmacological Interaction between Cisplatin (CDDP) and Histone Deacetylase Inhibitors (HDIs) in MDA-MB-231 Triple Negative Breast Cancer (TNBC) Cells with Altered Notch1 Activity-An Isobolographic Analysis.
Anna Wawruszak, Jarogniew J Luszczki, +4 authors, Andrzej Stepulak.
Int J Mol Sci, 2019 Jul 31; 20(15). PMID: 31357442    Free PMC article.
Cytotoxic and Antiproliferative Effects of Preussin, a Hydroxypyrrolidine Derivative from the Marine Sponge-Associated Fungus Aspergillus candidus KUFA 0062, in a Panel of Breast Cancer Cell Lines and Using 2D and 3D Cultures.
Fernanda Malhão, Alice A Ramos, +3 authors, Eduardo Rocha.
Mar Drugs, 2019 Aug 02; 17(8). PMID: 31366127    Free PMC article.
Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology.
Asadoor Amirkhani Namagerdi, Danila d'Angelo, +5 authors, Antonio Giordano.
Front Oncol, 2020 Dec 08; 10. PMID: 33282730    Free PMC article.
Clinical impact of interruption in adjuvant Trastuzumab therapy in patients with operable HER-2 positive breast cancer.
Sagar Sardesai, Jasmine Sukumar, +12 authors, Bhuvaneswari Ramaswamy.
Cardiooncology, 2020 Dec 10; 6(1). PMID: 33292843    Free PMC article.
Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance.
Mingjun Bi, Zhao Zhang, +18 authors, Zhijie Liu.
Nat Cell Biol, 2020 May 20; 22(6). PMID: 32424275    Free PMC article.
Biomarker predictors for immunotherapy benefit in breast: beyond PD-L1.
Jamaal L James, Justin M Balko.
Curr Breast Cancer Rep, 2020 Dec 15; 11(4). PMID: 33312343    Free PMC article.
Lactate Metabolism and Immune Modulation in Breast Cancer: A Focused Review on Triple Negative Breast Tumors.
Adviti Naik, Julie Decock.
Front Oncol, 2020 Dec 17; 10. PMID: 33324565    Free PMC article.
Germline Genetic Association between Stromal Interaction Molecule 1 (STIM1) and Clinical Outcomes in Breast Cancer Patients.
Chi-Cheng Huang, Min-Rou Lin, +3 authors, Wei-Chiao Chang.
J Pers Med, 2020 Dec 23; 10(4). PMID: 33348924    Free PMC article.
Cancer stem cell transcriptome landscape reveals biomarkers driving breast carcinoma heterogeneity.
Zhifa Zhang, Xiao Chen, Jianying Zhang, Xiaofeng Dai.
Breast Cancer Res Treat, 2021 Jan 04;. PMID: 33389402
Diagnostic Value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline Mammary Carcinoma.
Catarina Nascimento, Andreia Gameiro, +2 authors, Fernando Ferreira.
Cancers (Basel), 2021 Jan 07; 13(1). PMID: 33401382    Free PMC article.
An Integrative Computational Approach Based on Expression Similarity Signatures to Identify Protein-Protein Interaction Networks in Female-Specific Cancers.
Katia Pane, Ornella Affinito, +4 authors, Monica Franzese.
Front Genet, 2021 Jan 12; 11. PMID: 33424936    Free PMC article.
Combined crizotinib and endocrine drugs inhibit proliferation, migration, and colony formation of breast cancer cells via downregulation of MET and estrogen receptor.
Nehad M Ayoub, Amer E Alkhalifa, Dalia R Ibrahim, Ahmed Alhusban.
Med Oncol, 2021 Jan 16; 38(1). PMID: 33449292
Crizotinib induced antitumor activity and synergized with chemotherapy and hormonal drugs in breast cancer cells via downregulating MET and estrogen receptor levels.
Nehad M Ayoub, Dalia R Ibrahim, Amer E Alkhalifa, Belal A Al-Husein.
Invest New Drugs, 2020 Aug 25; 39(1). PMID: 32833135
DeePaN: deep patient graph convolutional network integrating clinico-genomic evidence to stratify lung cancers for immunotherapy.
Chao Fang, Dong Xu, +2 authors, Bolan Linghu.
NPJ Digit Med, 2021 Feb 04; 4(1). PMID: 33531613    Free PMC article.
Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing.
Ryan T Davis, Kerrigan Blake, +15 authors, Devon A Lawson.
Nat Cell Biol, 2020 Mar 08; 22(3). PMID: 32144411
Pathway Mutations in Breast Cancer Using Whole-Exome Sequencing.
Ya-Sian Chang, Chieh-Min Chang, +3 authors, Jan-Gowth Chang.
Oncol Res, 2019 Oct 03; 28(2). PMID: 31575382    Free PMC article.