Journal Article
. 2016 Feb; 17(3):299-308.
doi: 10.1016/S1470-2045(15)00544-6.

Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study

Scott Antonia 1 Sarah B Goldberg 2 Ani Balmanoukian 3 Jamie E Chaft 4 Rachel E Sanborn 5 Ashok Gupta 6 Rajesh Narwal 6 Keith Steele 6 Yu Gu 6 Joyson J Karakunnel 6 Naiyer A Rizvi 7 
Affiliations
  • PMID: 26858122
  •     16 References
  •     241 citations

Abstract

Background: PD-L1 and CTLA-4 immune checkpoints inhibit antitumour T-cell activity. Combination treatment with the anti-PD-L1 antibody durvalumab and the anti-CTLA-4 antibody tremelimumab might provide greater antitumour activity than either drug alone. We aimed to assess durvalumab plus tremelimumab in patients with advanced squamous or non-squamous non-small cell lung cancer (NSCLC).

Methods: We did a multicentre, non-randomised, open-label, phase 1b study at five cancer centres in the USA. We enrolled immunotherapy-naive patients aged 18 years or older with confirmed locally advanced or metastatic NSCLC. We gave patients durvalumab in doses of 3 mg/kg, 10 mg/kg, 15 mg/kg, or 20 mg/kg every 4 weeks, or 10 mg/kg every 2 weeks, and tremelimumab in doses of 1 mg/kg, 3 mg/kg, or 10 mg/kg every 4 weeks for six doses then every 12 weeks for three doses. The primary endpoint of the dose-escalation phase was safety. Safety analyses were based on the as-treated population. The dose-expansion phase of the study is ongoing. This study is registered with ClinicalTrials.gov, number NCT02000947.

Findings: Between Oct 28, 2013, and April 1, 2015, 102 patients were enrolled into the dose-escalation phase and received treatment. At the time of this analysis (June 1, 2015), median follow-up was 18·8 weeks (IQR 11-33). The maximum tolerated dose was exceeded in the cohort receiving durvalumab 20 mg/kg every 4 weeks plus tremelimumab 3 mg/kg, with two (30%) of six patients having a dose-limiting toxicity (one grade 3 increased aspartate aminotransferase and alanine aminotransferase and one grade 4 increased lipase). The most frequent treatment-related grade 3 and 4 adverse events were diarrhoea (11 [11%]), colitis (nine [9%]), and increased lipase (eight [8%]). Discontinuations attributable to treatment-related adverse events occurred in 29 (28%) of 102 patients. Treatment-related serious adverse events occurred in 37 (36%) of 102 patients. 22 patients died during the study, and three deaths were related to treatment. The treatment-related deaths were due to complications arising from myasthenia gravis (durvalumab 10 mg/kg every 4 weeks plus tremelimumab 1 mg/kg), pericardial effusion (durvalumab 20 mg/kg every 4 weeks plus tremelimumab 1 mg/kg), and neuromuscular disorder (durvalumab 20 mg/kg every 4 weeks plus tremelimumab 3 mg/kg). Evidence of clinical activity was noted both in patients with PD-L1-positive tumours and in those with PD-L1-negative tumours. Investigator-reported confirmed objective responses were achieved by six (23%, 95% CI 9-44) of 26 patients in the combined tremelimumab 1 mg/kg cohort, comprising two (22%, 95% CI 3-60) of nine patients with PD-L1-positive tumours and four (29%, 95% CI 8-58) of 14 patients with PD-L1-negative tumours, including those with no PD-L1 staining (four [40%, 95% CI 12-74] of ten patients).

Interpretation: Durvalumab 20 mg/kg every 4 weeks plus tremelimumab 1 mg/kg showed a manageable tolerability profile, with antitumour activity irrespective of PD-L1 status, and was selected as the dose for phase 3 studies, which are ongoing.

Funding: MedImmune.

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Curr Neurol Neurosci Rep, 2018 Feb 03; 18(1). PMID: 29392441
Review.
Novel active agents in patients with advanced NSCLC without driver mutations who have progressed after first-line chemotherapy.
Christian Manegold, Alex Adjei, +19 authors, Caicun Zhou.
ESMO Open, 2018 Feb 13; 1(6). PMID: 29435365    Free PMC article.
Immune Checkpoint Blockade: The New Frontier in Cancer Treatment.
Jeffrey M Clarke, Daniel J George, Stacey Lisi, April K S Salama.
Target Oncol, 2018 Feb 15; 13(1). PMID: 29441437
Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice.
Xuexiang Du, Mingyue Liu, +8 authors, Pan Zheng.
Cell Res, 2018 Feb 22; 28(4). PMID: 29463898    Free PMC article.
Highly Cited.
Analysis of response rate with ANTI PD1/PD-L1 monoclonal antibodies in advanced solid tumors: a meta-analysis of randomized clinical trials.
Alberto Carretero-González, David Lora, +6 authors, Guillermo de Velasco.
Oncotarget, 2018 Mar 02; 9(9). PMID: 29492229    Free PMC article.
PACIFIC trial: new perspectives for immunotherapy in lung cancer.
Francesco Agustoni, Fred R Hirsch.
Transl Lung Cancer Res, 2018 Mar 14; 7(Suppl 1). PMID: 29531898    Free PMC article.
Putting the brakes on CTLA-4 inhibition in lung cancer?
Meghan J Mooradian, Justin F Gainor.
Transl Lung Cancer Res, 2018 Mar 14; 7(Suppl 1). PMID: 29531902    Free PMC article.
Immunotherapy in treatment naïve advanced non-small cell lung cancer.
Vinicius Ernani, Apar Kishor Ganti.
J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593887    Free PMC article.
Review.
Immunotherapy combination strategies (non-chemotherapy) in non-small cell lung cancer.
Sandrine Niyongere, Andreas Saltos, Jhanelle E Gray.
J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593889    Free PMC article.
Review.
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.
Randi B Gombos, Ana Gonzalez, +24 authors, Nicholas S Wilson.
PLoS One, 2018 Apr 05; 13(4). PMID: 29617360    Free PMC article.
T Cell Calcium Signaling Regulation by the Co-Receptor CD5.
Claudia M Tellez Freitas, Deborah K Johnson, K Scott Weber.
Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701673    Free PMC article.
Review.
Programmed cell death-1 and programmed cell death ligand-1 antibodies-induced dysthyroidism.
Jaafar Jaafar, Eugenio Fernandez, Heba Alwan, Jacques Philippe.
Endocr Connect, 2018 May 10; 7(5). PMID: 29739808    Free PMC article.
Review.
Durvalumab: a potential maintenance therapy in surgery-ineligible non-small-cell lung cancer.
Michael R Shafique, Lary A Robinson, Scott Antonia.
Cancer Manag Res, 2018 May 16; 10. PMID: 29760563    Free PMC article.
Review.
Seronegative antibody-mediated neurology after immune checkpoint inhibitors.
Robert Wilson, David A Menassa, +11 authors, Sarosh R Irani.
Ann Clin Transl Neurol, 2018 May 16; 5(5). PMID: 29761126    Free PMC article.
Current landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC).
Young Kwang Chae, Ayush Arya, +4 authors, Francis Giles.
J Immunother Cancer, 2018 May 18; 6(1). PMID: 29769148    Free PMC article.
Highly Cited. Review.
Durvalumab after chemoradiotherapy in stage III non-small cell lung cancer.
Pascale Tomasini, Laurent Greillier, +2 authors, Fabrice Barlesi.
J Thorac Dis, 2018 Jun 01; 10(Suppl 9). PMID: 29850182    Free PMC article.
The emerging treatment landscape of advanced non-small cell lung cancer.
Panagiota Economopoulou, Giannis Mountzios.
Ann Transl Med, 2018 Jun 05; 6(8). PMID: 29862227    Free PMC article.
Review.
Breakthroughs in the treatment of advanced squamous-cell NSCLC: not the neglected sibling anymore?
Georgios Tsironis, Dimitrios C Ziogas, +4 authors, Meletios-Athanasios Dimopoulos.
Ann Transl Med, 2018 Jun 05; 6(8). PMID: 29862232    Free PMC article.
Review.
Current landscape of immunotherapy for the treatment of metastatic non-small-cell lung cancer.
A Pabani, C A Butts.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910652    Free PMC article.
Review.
Phase Ib/II trial evaluating the safety, tolerability and immunological activity of durvalumab (MEDI4736) (anti-PD-L1) plus tremelimumab (anti-CTLA-4) combined with FOLFOX in patients with metastatic colorectal cancer.
Jean-David Fumet, Nicolas Isambert, +6 authors, Francois Ghiringhelli.
ESMO Open, 2018 Jun 27; 3(4). PMID: 29942666    Free PMC article.
Advanced non-small cell lung cancer: the role of PD-L1 inhibitors.
David F Heigener, Martin Reck.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951298    Free PMC article.
Review.
Immunotherapy in the Asiatic population: any differences from Caucasian population?
Lunxi Peng, Yi-Long Wu.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951300    Free PMC article.
Review.
Immune-related adverse events with immune checkpoint inhibitors in thoracic malignancies: focusing on non-small cell lung cancer patients.
Jordi Remon, Laura Mezquita, +2 authors, Noemi Reguart.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951303    Free PMC article.
Review.
Shining light on advanced NSCLC in 2017: combining immune checkpoint inhibitors.
Meng Qiao, Tao Jiang, Caicun Zhou.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951304    Free PMC article.
Review.
Harmonization of PD-L1 testing in oncology: a Canadian pathology perspective.
D N Ionescu, M R Downes, A Christofides, M S Tsao.
Curr Oncol, 2018 Jul 03; 25(3). PMID: 29962847    Free PMC article.
Review.
Safety and efficacy of durvalumab (MEDI4736) in various solid tumors.
Hui Yang, Kai Shen, +3 authors, Xuelei Ma.
Drug Des Devel Ther, 2018 Jul 18; 12. PMID: 30013326    Free PMC article.
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.
S N Gettinger, J Choi, +19 authors, K A Schalper.
Nat Commun, 2018 Aug 12; 9(1). PMID: 30097571    Free PMC article.
Anti-PD-1/PD-L1 Therapy for Non-Small-Cell Lung Cancer: Toward Personalized Medicine and Combination Strategies.
Hongshu Sui, Ningxia Ma, +4 authors, Jiali Yang.
J Immunol Res, 2018 Aug 31; 2018. PMID: 30159341    Free PMC article.
Highly Cited. Review.
Immuno-Oncology: Emerging Targets and Combination Therapies.
Henry T Marshall, Mustafa B A Djamgoz.
Front Oncol, 2018 Sep 08; 8. PMID: 30191140    Free PMC article.
Highly Cited. Review.
New strategies in immunotherapy for lung cancer: beyond PD-1/PD-L1.
Nicolas Villanueva, Lyudmila Bazhenova.
Ther Adv Respir Dis, 2018 Sep 15; 12. PMID: 30215300    Free PMC article.
Review.
Cancer Immunotherapy in Diffuse Large B-Cell Lymphoma.
Jun Zhang, L Jeffrey Medeiros, Ken H Young.
Front Oncol, 2018 Sep 27; 8. PMID: 30250823    Free PMC article.
Review.
Durvalumab in NSCLC: latest evidence and clinical potential.
Nerea Muñoz-Unceta, Isabel Burgueño, Elizabeth Jiménez, Luis Paz-Ares.
Ther Adv Med Oncol, 2018 Oct 23; 10. PMID: 30344651    Free PMC article.
Review.
Immunotherapy for Urothelial Carcinoma: Current Evidence and Future Directions.
Abhishek Tripathi, Elizabeth R Plimack.
Curr Urol Rep, 2018 Nov 09; 19(12). PMID: 30406502
Review.
Anti PD-1 immunotherapy related interstitial lung disease presenting as respiratory failure - A review with case series.
Padmastuti Akella, Sundaravadivel Loganathan, +2 authors, Amos Lal.
Respir Med Case Rep, 2018 Nov 21; 26. PMID: 30456167    Free PMC article.
Current landscape of immunotherapy in the treatment of solid tumours, with future opportunities and challenges.
N A Nixon, N Blais, +5 authors, S Verma.
Curr Oncol, 2018 Nov 23; 25(5). PMID: 30464687    Free PMC article.
Review.
Clinical utility of tumor mutational burden in patients with non-small cell lung cancer treated with immunotherapy.
Lizza E Hendriks, Etienne Rouleau, Benjamin Besse.
Transl Lung Cancer Res, 2018 Dec 07; 7(6). PMID: 30505709    Free PMC article.
Review.
Recent developments in limited stage small cell lung cancer.
Kristin A Higgins, Sophia Gorgens, Lisa J Sudmeier, Corinne Faivre-Finn.
Transl Lung Cancer Res, 2019 Nov 02; 8(Suppl 2). PMID: 31673519    Free PMC article.
Review.
KEYNOTE-021 cohorts D and H suggest modest benefit in combining ipilimumab with pembrolizumab in second-line or later advanced non-small cell lung cancer treatment.
Amy Lauren Cummings, Kate M Santoso, Jonathan W Goldman.
Transl Lung Cancer Res, 2019 Nov 19; 8(5). PMID: 31737507    Free PMC article.
Antitumor Activity and Treatment-Related Toxicity Associated With Nivolumab Plus Ipilimumab in Advanced Malignancies: A Systematic Review and Meta-Analysis.
Hang Xu, Ping Tan, +5 authors, Qiang Wei.
Front Pharmacol, 2019 Nov 22; 10. PMID: 31749704    Free PMC article.
Systematic Review.
Combination of PD-L1 expression and NLR as prognostic marker in patients with surgically resected non-small cell lung cancer.
Xinyue Wang, Lianjing Cao, +3 authors, Richeng Jiang.
J Cancer, 2019 Nov 30; 10(26). PMID: 31777599    Free PMC article.
Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery.
Molly A Taylor, Adina M Hughes, +10 authors, Elizabeth L Hardaker.
J Immunother Cancer, 2019 Nov 30; 7(1). PMID: 31779705    Free PMC article.
Neurological Immune Related Adverse Events Associated with Nivolumab, Ipilimumab, and Pembrolizumab Therapy-Review of the Literature and Future Outlook.
Nora Möhn, Gernot Beutel, +3 authors, Thomas Skripuletz.
J Clin Med, 2019 Oct 28; 8(11). PMID: 31653079    Free PMC article.
Review.
Development of therapeutic antibodies for the treatment of diseases.
Ruei-Min Lu, Yu-Chyi Hwang, +4 authors, Han-Chung Wu.
J Biomed Sci, 2020 Jan 03; 27(1). PMID: 31894001    Free PMC article.
Review.
Long non-coding RNA LINC00243 promotes proliferation and glycolysis in non-small cell lung cancer cells by positively regulating PDK4 through sponging miR-507.
Xuegang Feng, Shengsheng Yang.
Mol Cell Biochem, 2019 Oct 09; 463(1-2). PMID: 31595421
Amplifying Outcomes: Checkpoint Inhibitor Combinations in First-Line Non-Small Cell Lung Cancer.
Barbara Melosky, Rosalyn Juergens, +5 authors, Quincy Chu.
Oncologist, 2019 May 30; 25(1). PMID: 31138727    Free PMC article.
Uniportal thoracoscopic pulmonary lobectomy in the treatment of Lung Cancer.
Jinying Zhang, Haixia Zhao, +2 authors, Yuzhen Sun.
Pak J Med Sci, 2020 Feb 18; 36(2). PMID: 32063956    Free PMC article.
Fatal Adverse Events Associated With Programmed Cell Death Ligand 1 Inhibitors: A Systematic Review and Meta-Analysis.
Xuewen Wang, Shijie Wu, +4 authors, Xiong Chen.
Front Pharmacol, 2020 Feb 23; 11. PMID: 32076409    Free PMC article.
Systematic Review.
Cancer immunotherapy with immunoadjuvants, nanoparticles, and checkpoint inhibitors: Recent progress and challenges in treatment and tracking response to immunotherapy.
Michael-Joseph Gorbet, Ashish Ranjan.
Pharmacol Ther, 2019 Dec 22; 207. PMID: 31863820    Free PMC article.
Review.
Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology.
Brian P Hobbs, Pedro C Barata, +16 authors, Gary L Rosner.
J Natl Cancer Inst, 2018 Dec 19; 111(2). PMID: 30561713    Free PMC article.
Review.
A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope.
Dong Li, Jing Li, Huanyu Chu, Zhuozhi Wang.
MAbs, 2020 Feb 15; 12(1). PMID: 32054416    Free PMC article.
Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy.
Xiaolei Li, Wenhui Song, +2 authors, Weidong Han.
Cell Mol Immunol, 2018 Jul 14; 16(1). PMID: 30002451    Free PMC article.
Review.
Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1-Low/Negative Recurrent or Metastatic HNSCC: The Phase 2 CONDOR Randomized Clinical Trial.
Lillian L Siu, Caroline Even, +18 authors, Jérôme Fayette.
JAMA Oncol, 2018 Nov 02; 5(2). PMID: 30383184    Free PMC article.
Highly Cited.
Retrospect and Prospect for Lung Cancer in China: Clinical Advances of Immune Checkpoint Inhibitors.
Shun Lu, Yongfeng Yu, Yi Yang.
Oncologist, 2019 Mar 02; 24(Suppl 1). PMID: 30819828    Free PMC article.
Review.
PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions.
Liliang Xia, Yuanyong Liu, Ying Wang.
Oncologist, 2019 Mar 02; 24(Suppl 1). PMID: 30819829    Free PMC article.
Review.
Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics.
Jasmine Davda, Paul Declerck, +5 authors, Eugenia Kraynov.
J Immunother Cancer, 2019 Apr 18; 7(1). PMID: 30992085    Free PMC article.
Review.
Emerging therapies for non-small cell lung cancer.
Chao Zhang, Natasha B Leighl, Yi-Long Wu, Wen-Zhao Zhong.
J Hematol Oncol, 2019 Apr 27; 12(1). PMID: 31023335    Free PMC article.
Highly Cited. Review.
Patient-Derived Non-Muscular Invasive Bladder Cancer Xenografts of Main Molecular Subtypes of the Tumor for Anti-Pd-l1 Treatment Assessment.
Ekaterina Blinova, Dmitry Roshchin, +9 authors, Andrey Kaprin.
Cells, 2019 Jun 05; 8(6). PMID: 31159302    Free PMC article.
Patients Selection for Immunotherapy in Solid Tumors: Overcome the Naïve Vision of a Single Biomarker.
Diego Signorelli, Patrizia Giannatempo, +11 authors, Immune-Oncology YOUNG Group.
Biomed Res Int, 2019 Jun 11; 2019. PMID: 31179334    Free PMC article.
Review.
Heterogeneity of PD-L1 expression in non-small cell lung cancer: Implications for specimen sampling in predicting treatment response.
Alexander Haragan, John K Field, +3 authors, John R Gosney.
Lung Cancer, 2019 Jul 20; 134. PMID: 31320000    Free PMC article.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges.
Kei Kunimasa, Taichiro Goto.
Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413    Free PMC article.
Review.
Combination checkpoint inhibitors for treatment of non-small-cell lung cancer: an update on dual anti-CTLA-4 and anti-PD-1/PD-L1 therapies.
Sonam Puri, Michael Shafique.
Drugs Context, 2020 Mar 12; 9. PMID: 32158484    Free PMC article.
Review.
Determinants of Resistance to Checkpoint Inhibitors.
Linda Tran, Dan Theodorescu.
Int J Mol Sci, 2020 Mar 01; 21(5). PMID: 32111080    Free PMC article.
Review.
Frontiers of ctDNA, targeted therapies, and immunotherapy in non-small-cell lung cancer.
Chennianci Zhu, Weihao Zhuang, +2 authors, Wen-Bin Ou.
Transl Lung Cancer Res, 2020 Mar 25; 9(1). PMID: 32206559    Free PMC article.
Review.
Treatment-Related Adverse Events of Combination Immune Checkpoint Inhibitors: Systematic Review and Meta-Analysis.
Robin Park, Laercio Lopes, +2 authors, Anwaar Saeed.
Front Oncol, 2020 Apr 08; 10. PMID: 32257944    Free PMC article.
Systematic Review.
Immunotherapy: From Advanced NSCLC to Early Stages, an Evolving Concept.
Thierry Berghmans, Valérie Durieux, Lizza E L Hendriks, Anne-Marie Dingemans.
Front Med (Lausanne), 2020 Apr 09; 7. PMID: 32266275    Free PMC article.
Systematic Review.
The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer.
Nanna Jørgensen, Gry Persson, Thomas Vauvert F Hviid.
Front Immunol, 2019 May 28; 10. PMID: 31134056    Free PMC article.
Review.
Durvalumab With or Without Tremelimumab vs Standard Chemotherapy in First-line Treatment of Metastatic Non-Small Cell Lung Cancer: The MYSTIC Phase 3 Randomized Clinical Trial.
Naiyer A Rizvi, Byoung Chul Cho, +28 authors, MYSTIC Investigators.
JAMA Oncol, 2020 Apr 10; 6(5). PMID: 32271377    Free PMC article.
New Approaches on Cancer Immunotherapy.
Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, Mien-Chie Hung.
Cold Spring Harb Perspect Med, 2019 Oct 17; 10(8). PMID: 31615865    Free PMC article.
Review.
Programmed death ligand-1 is associated with tumor infiltrating lymphocytes and poorer survival in urothelial cell carcinoma of the bladder.
Bo Wang, Wenwei Pan, +7 authors, Tianxin Lin.
Cancer Sci, 2018 Dec 15; 110(2). PMID: 30548363    Free PMC article.
Tolerability and efficacy of durvalumab in Japanese patients with advanced solid tumors.
Yutaka Fujiwara, Haruo Iguchi, +7 authors, Toshiyuki Kozuki.
Cancer Sci, 2019 Mar 21; 110(5). PMID: 30891877    Free PMC article.
Cancer in the time of COVID-19: expert opinion on how to adapt current practice.
Jo Raskin, Marnix Lebeer, +3 authors, Jan P van Meerbeeck.
Eur Respir J, 2020 Apr 18; 55(5). PMID: 32299866    Free PMC article.
Recent Advances in Lung Cancer Immunotherapy: Input of T-Cell Epitopes Associated With Impaired Peptide Processing.
Marine Leclerc, Laura Mezquita, +4 authors, Fathia Mami-Chouaib.
Front Immunol, 2019 Jul 25; 10. PMID: 31333652    Free PMC article.
Review.
Comparison of programmed death-ligand 1 (PD-L1) immunostain for nonsmall cell lung carcinoma between paired cytological and surgical specimens.
Huihong Xu, Laura Bratton, +2 authors, Zhongren Zhou.
Cytojournal, 2019 Jan 22; 15. PMID: 30662515    Free PMC article.
Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer: The Canadian Cancer Trials Group CO.26 Study.
Eric X Chen, Derek J Jonker, +18 authors, Chris J O'Callaghan.
JAMA Oncol, 2020 May 08; 6(6). PMID: 32379280    Free PMC article.
Soluble CD80 Protein Delays Tumor Growth and Promotes Tumor-Infiltrating Lymphocytes.
Lucas A Horn, Tiha M Long, +2 authors, Suzanne Ostrand-Rosenberg.
Cancer Immunol Res, 2017 Nov 11; 6(1). PMID: 29122838    Free PMC article.
Potential clinical application of tumor-infiltrating lymphocyte therapy for ovarian epithelial cancer prior or post-resistance to chemotherapy.
Donastas Sakellariou-Thompson, Marie-Andrée Forget, +5 authors, Chantale Bernatchez.
Cancer Immunol Immunother, 2019 Oct 12; 68(11). PMID: 31602489    Free PMC article.
Current Clinical Progress of PD-1/PD-L1 Immunotherapy and Potential Combination Treatment in Non-Small Cell Lung Cancer.
Jia-Xin Li, Ju-Min Huang, +4 authors, Pei-Yu Yan.
Integr Cancer Ther, 2019 Dec 17; 18. PMID: 31838881    Free PMC article.
Review.
PD-1/PD-L1 Based Combinational Cancer Therapy: Icing on the Cake.
Jian-Ye Zhang, Yan-Yan Yan, +2 authors, Li-Wu Fu.
Front Pharmacol, 2020 Jun 13; 11. PMID: 32528284    Free PMC article.
Review.
Cancer, immune suppression and Coronavirus Disease-19 (COVID-19): Need to manage drug safety (French Society for Oncology Pharmacy [SFPO] guidelines).
Florian Slimano, Amandine Baudouin, +12 authors, Catherine Rioufol.
Cancer Treat Rev, 2020 Jul 06; 88. PMID: 32623296    Free PMC article.
Review.
Combination of Ipilimumab and Nivolumab in Cancers: From Clinical Practice to Ongoing Clinical Trials.
Omid Kooshkaki, Afshin Derakhshani, +6 authors, Behzad Baradaran.
Int J Mol Sci, 2020 Jun 26; 21(12). PMID: 32580338    Free PMC article.
Review.
Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical Trial.
Eileen M O'Reilly, Do-Youn Oh, +11 authors, Philip Agop Philip.
JAMA Oncol, 2019 Jul 19; 5(10). PMID: 31318392    Free PMC article.
Highly Cited.
Durvalumab and tremelimumab combination therapy versus durvalumab or tremelimumab monotherapy for patients with solid tumors: A systematic review and meta-analysis.
Bi-Cheng Wang, Peng-Cheng Li, +2 authors, Quentin Liu.
Medicine (Baltimore), 2020 Jul 16; 99(28). PMID: 32664183    Free PMC article.
Systematic Review.
Update on Targeted Therapies for Advanced Non-Small Cell Lung Cancer: Durvalumab in Context.
Sneha Gullapalli, Jordi Remon, Lizza E L Hendriks, Gilberto Lopes.
Onco Targets Ther, 2020 Aug 09; 13. PMID: 32764980    Free PMC article.
Review.
Immune Checkpoint Inhibitor-Induced Myasthenia Gravis.
Yi-Te Huang, Ya-Ping Chen, +2 authors, Yuan-Ting Sun.
Front Neurol, 2020 Aug 09; 11. PMID: 32765397    Free PMC article.
Review.
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity.
Rong Tang, Jin Xu, +6 authors, Si Shi.
J Hematol Oncol, 2020 Aug 12; 13(1). PMID: 32778143    Free PMC article.
Review.
Drug-Related Pneumonitis in the Era of Precision Cancer Therapy.
Mizuki Nishino, Hiroto Hatabu, F Stephen Hodi, Nikhil H Ramaiya.
JCO Precis Oncol, 2017 May 26; 1. PMID: 32913972    Free PMC article.
Review.
[First-line Combination Immunotherapy in Advanced Non-small Cell Lung Cancer].
Xiaoxiao Peng, Qing Zhou.
Zhongguo Fei Ai Za Zhi, 2018 Dec 29; 21(12). PMID: 30591101    Free PMC article.
Review.
Compare the efficacy and safety of programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) inhibitors for advanced non-small cell lung cancer: a Bayesian analysis.
Jiaqi Liang, Ming Li, +7 authors, Lijie Tan.
Transl Lung Cancer Res, 2020 Sep 22; 9(4). PMID: 32953506    Free PMC article.
Combination approaches in NSCLC involving immune checkpoint inhibitors.
Surein Arulananda, Gareth Rivalland, Thomas John.
Lung Cancer Manag, 2016 Dec 01; 5(4). PMID: 30643561    Free PMC article.
Review.
Engineering Precision Medicine.
Wujin Sun, Junmin Lee, +3 authors, Ali Khademhosseini.
Adv Sci (Weinh), 2019 Jan 16; 6(1). PMID: 30643715    Free PMC article.
Review.
PD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer.
H K Angell, J Lee, +10 authors, E Kilgour.
Oncoimmunology, 2019 Feb 08; 8(2). PMID: 30729066    Free PMC article.
HBV and HIV/HBV Infected Patients Have Distinct Immune Exhaustion and Apoptotic Serum Biomarker Profiles.
Mohamed Tarek M Shata, Enass A Abdel-Hameed, +6 authors, Kenneth E Sherman.
Pathog Immun, 2019 Mar 01; 4(1). PMID: 30815625    Free PMC article.
Successful Treatment of Myasthenia Gravis Following PD-1/CTLA-4 Combination Checkpoint Blockade in a Patient With Metastatic Melanoma.
Jan-Michael Werner, Viola Schweinsberg, +6 authors, Norbert Galldiks.
Front Oncol, 2019 Mar 05; 9. PMID: 30828569    Free PMC article.
miR-1271 enhances the sensitivity of colorectal cancer cells to cisplatin.
Huixiang Yao, Qun Sun, Jinshui Zhu.
Exp Ther Med, 2019 May 16; 17(6). PMID: 31086572    Free PMC article.
A pooled meta-analysis of PD-1/L1 inhibitors incorporation therapy for advanced non-small cell lung cancer.
Ning Wan, Bo Ji, +4 authors, Wenjie Huang.
Onco Targets Ther, 2019 Jul 16; 12. PMID: 31303759    Free PMC article.
Review.
Programmed death-ligand 1 signaling pathway involves in bladder cancer growth and progression.
Elena A Samishina, Ekaterina V Blinova, +5 authors, Olesia V Kit'ko.
J Carcinog, 2019 Jul 31; 18. PMID: 31360124    Free PMC article.
Achievements and futures of immune checkpoint inhibitors in non-small cell lung cancer.
Zhenbin Qiu, Zihao Chen, Chao Zhang, Wenzhao Zhong.
Exp Hematol Oncol, 2019 Aug 30; 8. PMID: 31463163    Free PMC article.
Review.
The evolving immuno-oncology landscape in advanced lung cancer: first-line treatment of non-small cell lung cancer.
Jia Li Low, Robert J Walsh, +2 authors, Ross A Soo.
Ther Adv Med Oncol, 2019 Sep 10; 11. PMID: 31497071    Free PMC article.
Review.
Renal adverse effects following the use of different immune checkpoint inhibitor regimens: A real-world pharmacoepidemiology study of post-marketing surveillance data.
Gang Chen, Yan Qin, +3 authors, Xue-Mei Li.
Cancer Med, 2020 Jul 29; 9(18). PMID: 32720449    Free PMC article.
The New Immunotherapy Combinations in the Treatment of Advanced Non-Small Cell Lung Cancer: Reality and Perspectives.
Danilo Rocco, Luigi D Gravara, Cesare Gridelli.
Curr Clin Pharmacol, 2019 Aug 11; 15(1). PMID: 31400270    Free PMC article.
Review.
[Immune-related Adverse Events Induced by ICIs in Advanced NSCLC:
A Meta-analysis and Systematic Review].
Qiaoxi Qin, Jiajin Wang, Hong Wang.
Zhongguo Fei Ai Za Zhi, 2020 Aug 06; 23(9). PMID: 32752580    Free PMC article.
Systematic Review.
Adverse Effects of Anti-PD-1/PD-L1 Therapy in Non-small Cell Lung Cancer.
Chaoyue Su, Hui Wang, +7 authors, Jianye Zhang.
Front Oncol, 2020 Oct 20; 10. PMID: 33072580    Free PMC article.
Review.
Immunotherapy Breakthroughs in the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Christian Borel, Alain C Jung, Mickaël Burgy.
Cancers (Basel), 2020 Sep 25; 12(9). PMID: 32967162    Free PMC article.
Review.
The risk of diarrhea and colitis in patients with lung cancer treated with immune checkpoint inhibitors: a systematic review and meta-analysis.
K Bishay, P Tandon, +2 authors, J D McCurdy.
Curr Oncol, 2020 Nov 12; 27(5). PMID: 33173388    Free PMC article.
Systematic Review.
Combinational immunotherapy based on immune checkpoints inhibitors in small cell lung cancer: is this the beginning to reverse the refractory situation?
Haoyue Guo, Yayi He, +7 authors, Caicun Zhou.
J Thorac Dis, 2020 Nov 20; 12(10). PMID: 33209440    Free PMC article.
Review.
The mechanism of and the association between interleukin-27 and chemotherapeutic drug sensitivity in lung cancer.
Bingdong Jiang, Wenbo Shi, +3 authors, Chuanming Bao.
Oncol Lett, 2020 Nov 27; 21(1). PMID: 33240420    Free PMC article.
First line Immunotherapy for Non-Small Cell Lung Cancer.
Nicola J Nasser, Miguel Gorenberg, Abed Agbarya.
Pharmaceuticals (Basel), 2020 Nov 12; 13(11). PMID: 33171686    Free PMC article.
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Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial.
Christopher R Heery, Geraldine O'Sullivan-Coyne, +15 authors, James L Gulley.
Lancet Oncol, 2017 Apr 05; 18(5). PMID: 28373007    Free PMC article.
Highly Cited.
PD-L1 inhibition with avelumab for metastatic Merkel cell carcinoma.
Maria Rita Gaiser, Michelle Bongiorno, Isaac Brownell.
Expert Rev Clin Pharmacol, 2018 Feb 27; 11(4). PMID: 29478343    Free PMC article.
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Checkpoint inhibitors: What gastroenterologists need to know.
Monjur Ahmed.
World J Gastroenterol, 2019 Jan 10; 24(48). PMID: 30622372    Free PMC article.
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Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma.
Houda Bahig, Francine Aubin, +14 authors, Philip Wong.
BMC Cancer, 2019 Jan 16; 19(1). PMID: 30642290    Free PMC article.
Recent success and limitations of immune checkpoint inhibitors for cancer: a lesson from melanoma.
Margaret Ottaviano, Sabino De Placido, Paolo Antonio Ascierto.
Virchows Arch, 2019 Feb 13; 474(4). PMID: 30747264
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Targeting Immune Checkpoints in Lung Cancer: Current Landscape and Future Prospects.
Long Long, Chen Zhao, +3 authors, Honglei Chen.
Clin Drug Investig, 2019 Feb 20; 39(4). PMID: 30778885
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The safety and tolerability of combined immune checkpoint inhibitors (anti-PD-1/PD-L1 plus anti-CTLA-4): a systematic review and meta-analysis.
Lihu Gu, Parikshit Asutosh Khadaroo, +8 authors, Manman Chen.
BMC Cancer, 2019 Jun 12; 19(1). PMID: 31182049    Free PMC article.
Systematic Review.
Combination of CTLA-4 and PD-1 blockers for treatment of cancer.
Anand Rotte.
J Exp Clin Cancer Res, 2019 Jun 15; 38(1). PMID: 31196207    Free PMC article.
Highly Cited. Review.
Phase II study of durvalumab and tremelimumab in pulmonary sarcomatoid carcinoma: KCSG-LU16-07.
Miso Kim, Bhumsuk Keam, +15 authors, Dae Seog Heo.
Thorac Cancer, 2020 Oct 08; 11(12). PMID: 33026712    Free PMC article.
Safety and Efficacy of Durvalumab and Tremelimumab Alone or in Combination in Patients with Advanced Gastric and Gastroesophageal Junction Adenocarcinoma.
Ronan J Kelly, Jeeyun Lee, +21 authors, Geoffrey Y Ku.
Clin Cancer Res, 2019 Nov 05; 26(4). PMID: 31676670    Free PMC article.
The Advanced Practice Provider Perspective: Treating Patients With Immuno-Oncology Combination Therapy Across Tumor Types.
Brianna Hoffner, Renae Vaughn, Maureen Reed, Melinda S Weber.
J Adv Pract Oncol, 2019 May 01; 10(4). PMID: 33343985    Free PMC article.
Review.
Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy.
Marsha Pellegrino, Francesca Del Bufalo, +3 authors, Emmanuel de Billy.
Cells, 2020 Dec 31; 10(1). PMID: 33374128    Free PMC article.
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A Canadian cancer trials group phase IB study of durvalumab (anti-PD-L1) plus tremelimumab (anti-CTLA-4) given concurrently or sequentially in patients with advanced, incurable solid malignancies.
J Nehra, P A Bradbury, +16 authors, M Smoragiewicz.
Invest New Drugs, 2020 Feb 06; 38(5). PMID: 32020438
The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities.
Fatemeh Bayati, Mahsa Mohammadi, +3 authors, Ehsan Sharif-Paghaleh.
Front Immunol, 2021 Feb 02; 11. PMID: 33519807    Free PMC article.
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Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
Darren J Schofield, Jennifer Percival-Alwyn, +18 authors, Michael Oberst.
MAbs, 2021 Jan 06; 13(1). PMID: 33397194    Free PMC article.
Immune checkpoint: The novel target for antitumor therapy.
Xianghu Jiang, Guohong Liu, Yirong Li, Yunbao Pan.
Genes Dis, 2019 Dec 20; 8(1). PMID: 33569511    Free PMC article.
Review.
Expression of Human Epidermal Growth Factor Receptor-2 Status and Programmed Cell Death Protein-1 Ligand Is Associated With Prognosis in Gastric Cancer.
Huifang Lv, Junling Zhang, +7 authors, Xiaobing Chen.
Front Oncol, 2021 Feb 19; 10. PMID: 33598422    Free PMC article.
Phage Display Technology as a Powerful Platform for Antibody Drug Discovery.
Kazuya Nagano, Yasuo Tsutsumi.
Viruses, 2021 Jan 29; 13(2). PMID: 33504115    Free PMC article.
Review.
The progress and challenge of anti-PD-1/PD-L1 immunotherapy in treating non-small cell lung cancer.
Jingjing Qu, Quanhui Mei, +4 authors, Jianying Zhou.
Ther Adv Med Oncol, 2021 Mar 02; 13. PMID: 33643442    Free PMC article.
Review.
COMMD1, from the Repair of DNA Double Strand Breaks, to a Novel Anti-Cancer Therapeutic Target.
Amila Suraweera, Pascal H G Duijf, +5 authors, Derek J Richard.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33669398    Free PMC article.
Myasthenia gravis and concurrent myositis following PD-L1 checkpoint inhibitor for non-small cell lung cancer.
Chun Seng Phua, Ari Murad, +2 authors, Cecilia Cappelen-Smith.
BMJ Neurol Open, 2021 Mar 09; 2(1). PMID: 33681778    Free PMC article.
Analysis of the differences in lung cancer research trends between China and the United States based using project funding data.
Yuansheng Zheng, Yiwei Huang, +9 authors, Qun Wang.
Ann Transl Med, 2021 Mar 13; 9(3). PMID: 33708842    Free PMC article.
Delivery of gefitinib with an immunostimulatory nanocarrier improves therapeutic efficacy in lung cancer.
Dingwei Diao, Jianxue Zhai, +7 authors, Kaican Cai.
Transl Lung Cancer Res, 2021 Mar 16; 10(2). PMID: 33718033    Free PMC article.
A Review of Monoclonal Antibody-Based Treatments in Non-small Cell Lung Cancer.
Yunes Panahi, Amir Hossein Mohammadzadeh, +3 authors, Amirhossein Sahebkar.
Adv Exp Med Biol, 2021 Mar 17; 1286. PMID: 33725344
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Lessons From Immune Checkpoint Inhibitor Trials in Hepatocellular Carcinoma.
Raphael Mohr, Fabian Jost-Brinkmann, +7 authors, Christoph Roderburg.
Front Immunol, 2021 Apr 17; 12. PMID: 33859646    Free PMC article.
Review.
Treatment beyond progression with anti-PD-1/PD-L1 based regimens in advanced solid tumors: a systematic review.
Francesco Spagnolo, Andrea Boutros, +3 authors, Paola Queirolo.
BMC Cancer, 2021 Apr 19; 21(1). PMID: 33865350    Free PMC article.
Systematic Review.
Safety monitoring of two and four-weekly adjuvant durvalumab for patients with stage III NSCLC: implications for the COVID-19 pandemic and beyond.
Kroopa Joshi, Abdul Muhith, +7 authors, Anna Minchom.
Lung Cancer, 2021 May 10; 156. PMID: 33965281    Free PMC article.
Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer.
Roberto Ferrara, Martina Imbimbo, +4 authors, Virginie Westeel.
Cochrane Database Syst Rev, 2020 Dec 15; 12. PMID: 33316104    Free PMC article.
Systematic Review.
Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer.
Roberto Ferrara, Martina Imbimbo, +4 authors, Virginie Westeel.
Cochrane Database Syst Rev, 2021 May 01; 4. PMID: 33930176    Free PMC article.
Systematic Review.
Treatment-Related Serious Adverse Events of Immune Checkpoint Inhibitors in Clinical Trials: A Systematic Review.
Tao Ouyang, Yanyan Cao, +7 authors, Chuansheng Zheng.
Front Oncol, 2021 May 29; 11. PMID: 34046338    Free PMC article.
Systematic Review.
Durvalumab Plus Tremelimumab in Solid Tumors: A Systematic Review.
Caterina Arru, Maria Rosaria De Miglio, +4 authors, Panagiotis Paliogiannis.
Adv Ther, 2021 Jun 10; 38(7). PMID: 34105088    Free PMC article.
Systematic Review.
Immunotherapy in Treating EGFR-Mutant Lung Cancer: Current Challenges and New Strategies.
Kenneth K W To, Winnie Fong, William C S Cho.
Front Oncol, 2021 Jun 12; 11. PMID: 34113560    Free PMC article.
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Immunotherapy in endometrial cancer: rationale, practice and perspectives.
Wenyu Cao, Xinyue Ma, +3 authors, Qing Zhang.
Biomark Res, 2021 Jun 18; 9(1). PMID: 34134781    Free PMC article.
Review.
Comparisons of Underlying Mechanisms, Clinical Efficacy and Safety Between Anti-PD-1 and Anti-PD-L1 Immunotherapy: The State-of-the-Art Review and Future Perspectives.
Yating Zhao, Liu Liu, Liang Weng.
Front Pharmacol, 2021 Jul 27; 12. PMID: 34305619    Free PMC article.
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Inhibitors Targeting CDK9 Show High Efficacy against Osimertinib and AMG510 Resistant Lung Adenocarcinoma Cells.
Jaya Padmanabhan, Biswarup Saha, +3 authors, Srikumar Chellappan.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359807    Free PMC article.
The Landscape of Immunotherapy in Advanced NSCLC: Driving Beyond PD-1/PD-L1 Inhibitors (CTLA-4, LAG3, IDO, OX40, TIGIT, Vaccines).
Andrea De Giglio, Alessandro Di Federico, +2 authors, Francesco Gelsomino.
Curr Oncol Rep, 2021 Aug 29; 23(11). PMID: 34453261    Free PMC article.
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Phase II study of durvalumab plus tremelimumab as therapy for patients with previously treated anti-PD-1/PD-L1 resistant stage IV squamous cell lung cancer (Lung-MAP substudy S1400F, NCT03373760).
Natasha B Leighl, Mary W Redman, +16 authors, David R Gandara.
J Immunother Cancer, 2021 Aug 26; 9(8). PMID: 34429332    Free PMC article.
Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study.
Robin Kate Kelley, Bruno Sangro, +21 authors, Ghassan K Abou-Alfa.
J Clin Oncol, 2021 Jul 23; 39(27). PMID: 34292792    Free PMC article.
Expression of p53 Protein Associates with Anti-PD-L1 Treatment Response on Human-Derived Xenograft Model of GATA3/CR5/6-Negative Recurrent Nonmuscular Invasive Bladder Urothelial Carcinoma.
Ekaterina Blinova, Elena Samishina, +16 authors, Andrew Kozdoba.
Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34576020    Free PMC article.
Research Progresses in Immunological Checkpoint Inhibitors for Breast Cancer Immunotherapy.
Wenxiang Zhang, Xiangyi Kong, +6 authors, Jing Wang.
Front Oncol, 2021 Oct 12; 11. PMID: 34631507    Free PMC article.
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Research Progress and Challenges in the Treatment of Central Nervous System Metastasis of Non-Small Cell Lung Cancer.
Bin Wang, Hanfei Guo, +3 authors, Gang Zhao.
Cells, 2021 Oct 24; 10(10). PMID: 34685600    Free PMC article.
Review.
Reporting quality of randomized, controlled trials evaluating immunotherapy in lung cancer.
Jun Du, Yundi Zhang, +5 authors, Zhijie Wang.
Thorac Cancer, 2021 Aug 26; 12(20). PMID: 34432361    Free PMC article.
Immune Checkpoint Inhibitor (ICI)-Related Cardiotoxicity.
Abdulrazzak Zarifa, Juan Lopez-Mattei, +3 authors, Peter Y Kim.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972975
Comprehensive analysis of PD-L1 in non-small cell lung cancer with emphasis on survival benefit, impact of driver mutation and histological types, and archival tissue.
Chin-Chou Wang, Kuo-Tung Huang, +6 authors, Meng-Chih Lin.
Thorac Cancer, 2021 Nov 30; 13(1). PMID: 34841687    Free PMC article.
Immune Checkpoint Inhibitor-Associated Colitis: From Mechanism to Management.
Liansha Tang, Jialing Wang, +4 authors, Xuelei Ma.
Front Immunol, 2022 Jan 08; 12. PMID: 34992611    Free PMC article.
Review.
Immune checkpoint-targeted antibodies: a room for dose and schedule optimization?
Christophe Maritaz, Sophie Broutin, +2 authors, Angelo Paci.
J Hematol Oncol, 2022 Jan 17; 15(1). PMID: 35033167    Free PMC article.
Review.
A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies.
Yuan-Chin Hsieh, Jun-Min Liao, +11 authors, Tian-Lu Cheng.
J Nanobiotechnology, 2022 Feb 02; 20(1). PMID: 35101043    Free PMC article.
Risk of colitis in immune checkpoint inhibitors and in chemotherapy/placebo for solid tumors: a systematic review and meta-analysis.
Wei Wei, Yun Ding, Jiajia He, Jun Wu.
Transl Cancer Res, 2020 Jul 01; 9(7). PMID: 35117786    Free PMC article.
Navigational bronchoscopy specimens and PD-L1 expression: a retrospective study.
Hussein Asad, Timothy Saettele, +2 authors, Matthew Aboudara.
J Thorac Dis, 2022 Mar 15; 14(2). PMID: 35280465    Free PMC article.
Longitudinal changes of blood parameters and weight in inoperable stage III NSCLC patients treated with concurrent chemoradiotherapy followed by maintenance treatment with durvalumab.
J Guggenberger, S Kenndoff, +5 authors, F Manapov.
BMC Cancer, 2022 Mar 26; 22(1). PMID: 35331196    Free PMC article.
Multimodality Treatment of Pulmonary Sarcomatoid Carcinoma: A Review of Current State of Art.
Lin Zhang, Weihao Lin, +3 authors, Jie He.
J Oncol, 2022 Apr 05; 2022. PMID: 35368903    Free PMC article.
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Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons.
Adel Naimi, Rebar N Mohammed, +11 authors, Ehsan Razeghian.
Cell Commun Signal, 2022 Apr 09; 20(1). PMID: 35392976    Free PMC article.
Review.
Immune checkpoint inhibitor-associated ophthalmic adverse events: current understanding of its mechanisms, diagnosis, and management.
Yu-Wen Zhou, Qian Xu, +3 authors, Xue-Lei Ma.
Int J Ophthalmol, 2022 Apr 23; 15(4). PMID: 35450191    Free PMC article.
Review.
Review of Immune-Related Adverse Events (irAEs) in Non-Small-Cell Lung Cancer (NSCLC)-Their Incidence, Management, Multiorgan irAEs, and Rechallenge.
Raju Vaddepally, Rajiv Doddamani, +6 authors, Abhinav B Chandra.
Biomedicines, 2022 Apr 24; 10(4). PMID: 35453540    Free PMC article.
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Drug resistance in cancer immunotherapy: new strategies to improve checkpoint inhibitor therapies.
Jesus Rodriguez-Pascual, Angel Ayuso-Sacido, Cristobal Belda-Iniesta.
Cancer Drug Resist, 2019 Dec 19; 2(4). PMID: 35582274    Free PMC article.
Review.
Immunotherapy in Penile Squamous Cell Carcinoma: Present or Future? Multi-Target Analysis of Programmed Cell Death Ligand 1 Expression and Microsatellite Instability.
Marco Montella, Rosalaura Sabetta, +18 authors, Federica Zito Marino.
Front Med (Lausanne), 2022 May 21; 9. PMID: 35592855    Free PMC article.