PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

Weiping Zou ¹, Jedd D Wolchok ², Lieping Chen ³

Affiliations

¹ Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. wzou@med.umich.edu wolchokj@mskcc.org lieping.chen@yale.edu.
² Department of Medicine and the Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. wzou@med.umich.edu wolchokj@mskcc.org lieping.chen@yale.edu.
³ Department of Immunobiology, Yale University School of Medicine, New Haven CT 06519, USA. wzou@med.umich.edu wolchokj@mskcc.org lieping.chen@yale.edu.

PMID: 26936508
176 References
815 citations

Abstract

PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy and has elicited durable antitumor responses and long-term remissions in a subset of patients with a broad spectrum of cancers. How to improve, widen, and predict the clinical response to anti-PD therapy is a central theme in the field of cancer immunology and immunotherapy. Oncologic, immunologic, genetic, and biological studies focused on the human cancer microenvironment have yielded substantial insight into this issue. Here, we focus on tumor microenvironment and evaluate several potential therapeutic response markers including the PD-L1 and PD-1 expression pattern, genetic mutations within cancer cells and neoantigens, cancer epigenetics and effector T cell landscape, and microbiota. We further clarify the mechanisms of action of these markers and their roles in shaping, being shaped, and/or predicting therapeutic responses. We also discuss a variety of combinations with PD pathway blockade and their scientific rationales for cancer treatment.

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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy. Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas. Cell, 2017 Feb 12; 168(4). PMID: 28187290 Free PMC article. Highly Cited. Review.
Tumor-infiltrating lymphocyte composition, organization and PD-1/ PD-L1 expression are linked in breast cancer. Laurence Buisseret, Soizic Garaud, +14 authors, Karen Willard-Gallo. less Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197375 Free PMC article. Highly Cited.
A human programmed death-ligand 1-expressing mouse tumor model for evaluating the therapeutic efficacy of anti-human PD-L1 antibodies. Anfei Huang, Di Peng, +8 authors, F Xiao-Feng Qin. less Sci Rep, 2017 Feb 17; 7. PMID: 28202921 Free PMC article.
Macrophages Polarized by Expression of ToxoGRA15II Inhibit Growth of Hepatic Carcinoma. Yuanling Li, Faustina Poppoe, +6 authors, Jilong Shen. less Front Immunol, 2017 Mar 01; 8. PMID: 28243242 Free PMC article.
Inflammatory cytokines compromise programmed cell death-1 (PD-1)-mediated T cell suppression in inflammatory arthritis through up-regulation of soluble PD-1. D Bommarito, C Hall, L S Taams, V M Corrigall. Clin Exp Immunol, 2017 Mar 01; 188(3). PMID: 28245522 Free PMC article.
Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade. Fei Zhang, Hudie Wei, +8 authors, Aiwu Zhou. less Cell Discov, 2017 Mar 11; 3. PMID: 28280600 Free PMC article.
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity. Vikram R Juneja, Kathleen A McGuire, +5 authors, Arlene H Sharpe. less J Exp Med, 2017 Mar 18; 214(4). PMID: 28302645 Free PMC article. Highly Cited.
Immune checkpoint dysfunction in large and medium vessel vasculitis. Ryu Watanabe, Hui Zhang, +2 authors, Gerald Berry, Jörg J Goronzy, Cornelia M Weyand. less Am J Physiol Heart Circ Physiol, 2017 Mar 21; 312(5). PMID: 28314758 Free PMC article. Review.
PD-L1 expression in pancreatic ductal adenocarcinoma is a poor prognostic factor in patients with high CD8+ tumor-infiltrating lymphocytes: highly sensitive detection using phosphor-integrated dot staining. So Yamaki, Hiroaki Yanagimoto, +2 authors, Koji Tsuta, Hironori Ryota, Masanori Kon. less Int J Clin Oncol, 2017 Mar 21; 22(4). PMID: 28314962 Free PMC article.
Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition. Florine A Eggink, Inge C Van Gool, +11 authors, Tjalling Bosse. less Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344870 Free PMC article.
CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy. Nan Chen, Aurore Morello, Zachary Tano, Prasad S Adusumilli. Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344886 Free PMC article.
STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer. Rui Li, Fang Fang, +13 authors, Weihua Xiao. less Sci Rep, 2017 Mar 30; 7. PMID: 28350008 Free PMC article.
The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. Yichuan Xiao, Qiang Zou, +13 authors, Shao-Cong Sun. less J Exp Med, 2017 Mar 31; 214(5). PMID: 28356390 Free PMC article.
PDL1 expression is a poor-prognosis factor in soft-tissue sarcomas. François Bertucci, Pascal Finetti, +7 authors, Emilie Mamessier. less Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405501 Free PMC article.
High expression of B7-H6 in human glioma tissues promotes tumor progression. Tianwei Jiang, Wei Wu, +6 authors, Chunhua Hang. less Oncotarget, 2017 Apr 19; 8(23). PMID: 28415577 Free PMC article.
New transcriptional-based insights into the pathogenesis of desmoplastic small round cell tumors (DSRCTs). Tiziana Negri, Silvia Brich, +7 authors, Silvana Pilotti. less Oncotarget, 2017 Apr 19; 8(20). PMID: 28415643 Free PMC article.
Expression of PD-L1 and prognosis in breast cancer: a meta-analysis. Minghui Zhang, Houbin Sun, +4 authors, Qingyuan Zhang. less Oncotarget, 2017 Apr 22; 8(19). PMID: 28430626 Free PMC article. Highly Cited.
A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway. Lei Zhao, Cheng Li, +6 authors, Chunlin Ge. less Onco Targets Ther, 2017 Apr 27; 10. PMID: 28442920 Free PMC article.
Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model. Kyoung-Jin Kim, Ji-Hye Kim, +3 authors, Jinsil Seong. less Oncotarget, 2017 May 04; 8(25). PMID: 28465485 Free PMC article.
Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab. Udupi A Ramagopal, Weifeng Liu, +10 authors, Steven C Almo. less Proc Natl Acad Sci U S A, 2017 May 10; 114(21). PMID: 28484017 Free PMC article.
Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Yuying Liu, Xiaoyu Liang, +18 authors, Bo Huang. less Nat Commun, 2017 May 11; 8. PMID: 28488695 Free PMC article.
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy. Jan Willem Kleinovink, Koen A Marijt, +3 authors, Marieke F Fransen. less Oncoimmunology, 2017 May 17; 6(4). PMID: 28507803 Free PMC article. Highly Cited.
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Sydney R Gordon, Roy L Maute, +10 authors, Irving L Weissman. less Nature, 2017 May 18; 545(7655). PMID: 28514441 Free PMC article. Highly Cited.
Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans. Kenji Tsuchihashi, Hitoshi Kusaba, +19 authors, Eishi Baba. less Mol Clin Oncol, 2017 May 19; 6(5). PMID: 28515919 Free PMC article.
Showing the Way: Oncolytic Adenoviruses as Chaperones of Immunostimulatory Adjuncts. Jing Li Huang, Christopher J LaRocca, Masato Yamamoto. Biomedicines, 2017 May 26; 4(3). PMID: 28536390 Free PMC article. Review.
Delivering safer immunotherapies for cancer. Lauren Milling, Yuan Zhang, Darrell J Irvine. Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888 Free PMC article. Highly Cited. Review.
Quantitative Mass Spectrometry Analysis of PD-L1 Protein Expression, N-glycosylation and Expression Stoichiometry with PD-1 and PD-L2 in Human Melanoma. Carlos A Morales-Betanzos, Hyoungjoo Lee, +4 authors, Daniel C Liebler. less Mol Cell Proteomics, 2017 May 27; 16(10). PMID: 28546465 Free PMC article.
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nisha Nagarsheth, Max S Wicha, Weiping Zou. Nat Rev Immunol, 2017 May 31; 17(9). PMID: 28555670 Free PMC article. Highly Cited. Review.
Bisdemethoxycurcumin in combination with α-PD-L1 antibody boosts immune response against bladder cancer. Yiqun Shao, Wenjing Zhu, +4 authors, Zhong Wang. less Onco Targets Ther, 2017 Jun 06; 10. PMID: 28579805 Free PMC article.
IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours. Hyungseok Seo, Insu Jeon, +15 authors, Chang-Yuil Kang. less Nat Commun, 2017 Jun 07; 8. PMID: 28585539 Free PMC article.
Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients. M F Sanmamed, J L Perez-Gracia, +17 authors, I Melero. less Ann Oncol, 2017 Jun 09; 28(8). PMID: 28595336 Free PMC article. Highly Cited.
Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity. Ryu Watanabe, Tsuyoshi Shirai, +9 authors, Cornelia M Weyand. less J Clin Invest, 2017 Jun 13; 127(7). PMID: 28604383 Free PMC article.
New insights into the role of EMT in tumor immune escape. Stéphane Terry, Pierre Savagner, +4 authors, Salem Chouaib. less Mol Oncol, 2017 Jun 15; 11(7). PMID: 28614624 Free PMC article. Highly Cited. Review.
PD-L1 protein expression in non-small cell lung cancer based on different immunohistochemical antibodies. Minghui Zhang, Di Feng, +3 authors, Jing Jing, Hang Liu, Shu Zhao, Qingyuan Zhang. less J Thorac Dis, 2017 Jun 16; 9(5). PMID: 28616312 Free PMC article.
β-Catenin in desmoid-type fibromatosis: deep insights into the role of T41A and S45F mutations on protein structure and gene expression. Chiara Colombo, Antonino Belfiore, +13 authors, Federica Perrone. less Mol Oncol, 2017 Jun 20; 11(11). PMID: 28627792 Free PMC article.
PD-1 and cancer: molecular mechanisms and polymorphisms. Arash Salmaninejad, Vahid Khoramshahi, +6 authors, Sayed Mostafa Hosseini. less Immunogenetics, 2017 Jun 24; 70(2). PMID: 28642997 Review.
Immunological effects of hypomethylating agents. Katherine E Lindblad, Meghali Goswami, Christopher S Hourigan, Karolyn A Oetjen. Expert Rev Hematol, 2017 Jun 24; 10(8). PMID: 28644756 Free PMC article. Review.
Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages. Liang Cheng, Jiatao Liu, +10 authors, Guoping Sun. less Int J Biol Sci, 2017 Jun 29; 13(6). PMID: 28655998 Free PMC article.
Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours. Mira M Shenouda, Amy Gillgrass, +10 authors, Ali A Ashkar. less Breast Cancer Res, 2017 Jul 03; 19(1). PMID: 28668076 Free PMC article.
Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease? Neil Dunavin, Ajoy Dias, Meizhang Li, Joseph McGuirk. Biomedicines, 2017 Jul 04; 5(3). PMID: 28671556 Free PMC article. Review.
Endogenous Heat-Shock Protein Induction with or Without Radiofrequency Ablation or Cryoablation in Patients with Stage IV Melanoma. Evidio Domingo-Musibay, James M Heun, +5 authors, Svetomir N Markovic. less Oncologist, 2017 Jul 07; 22(9). PMID: 28679643 Free PMC article.
Chemotherapeutic tumor microparticles combining low-dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway. Yanling Sun, Zu'an Zheng, +12 authors, Bo Huang. less Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680743 Free PMC article.
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. TaChung Yu, Fangfang Guo, +12 authors, Jing-Yuan Fang. less Cell, 2017 Jul 29; 170(3). PMID: 28753429 Free PMC article. Highly Cited.
New PD-L1 inhibitors in non-small cell lung cancer - impact of atezolizumab. Nagashree Seetharamu, Isabel R Preeshagul, Kevin M Sullivan. Lung Cancer (Auckl), 2017 Aug 02; 8. PMID: 28761384 Free PMC article. Review.
Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells. Peihong Dai, Weiyi Wang, +7 authors, Liang Deng. less Sci Immunol, 2017 Aug 02; 2(11). PMID: 28763795 Free PMC article.
PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy. Junyu Long, Jianzhen Lin, +7 authors, Haitao Zhao. less J Hematol Oncol, 2017 Aug 05; 10(1). PMID: 28774337 Free PMC article. Review.
Targeting Immune System Alterations in Hodgkin Lymphoma. Natalie S Grover, Barbara Savoldo. Curr Hematol Malig Rep, 2017 Aug 07; 12(4). PMID: 28780614 Free PMC article. Review.
Pembrolizumab reactivates pulmonary granulomatosis. Majdi Al-Dliw, Mohammed Megri, +3 authors, Yousef Shweihat. less Respir Med Case Rep, 2017 Aug 11; 22. PMID: 28794963 Free PMC article.
89Zr-labeled nivolumab for imaging of T-cell infiltration in a humanized murine model of lung cancer. Christopher G England, Dawei Jiang, +7 authors, Weibo Cai. less Eur J Nucl Med Mol Imaging, 2017 Aug 20; 45(1). PMID: 28821924 Free PMC article.
T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics. Z Wu, N V Cheung. Pharmacol Ther, 2017 Aug 24; 182. PMID: 28834699 Free PMC article. Review.
PD-L1 expression in lung cancer and its correlation with driver mutations: a meta-analysis. Minghui Zhang, Guoliang Li, +5 authors, Yan Wang. less Sci Rep, 2017 Sep 02; 7(1). PMID: 28860576 Free PMC article. Highly Cited.
Prognostic significance of PD-L1 expression and 18F-FDG PET/CT in surgical pulmonary squamous cell carcinoma. Minghui Zhang, Dalong Wang, +5 authors, Qiangyuan Zhang. less Oncotarget, 2017 Sep 09; 8(31). PMID: 28881674 Free PMC article.
Analysis of the whole transcriptome from gingivo-buccal squamous cell carcinoma reveals deregulated immune landscape and suggests targets for immunotherapy. Richa Singh, Navonil De Sarkar, +6 authors, Bidyut Roy. less PLoS One, 2017 Sep 09; 12(9). PMID: 28886030 Free PMC article.
Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4. Samarchith P Kurup, Nyamekye Obeng-Adjei, +5 authors, John T Harty. less Nat Med, 2017 Sep 12; 23(10). PMID: 28892065 Free PMC article.
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Ying Zhang, Raj Kurupati, +17 authors, Hildegund C J Ertl. less Cancer Cell, 2017 Sep 13; 32(3). PMID: 28898698 Free PMC article. Highly Cited.
Genomic Analysis of Tumor Microenvironment Immune Types across 14 Solid Cancer Types: Immunotherapeutic Implications. Yu-Pei Chen, Yu Zhang, +9 authors, Jun Ma. less Theranostics, 2017 Sep 16; 7(14). PMID: 28912897 Free PMC article. Highly Cited.
[Novel Immuno-oncology Therapy: Current Status of Clinical Research and Prospect of Application]. Shijia Zhang, Shengxiang Ren. Zhongguo Fei Ai Za Zhi, 2017 Sep 25; 20(9). PMID: 28935020 Free PMC article. Review.
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Jingying Zhou, Man Liu, +17 authors, Alfred Sze-Lok Cheng. less Gut, 2017 Sep 25; 67(5). PMID: 28939663 Free PMC article.
B cells in the pathophysiology of myasthenia gravis. John S Yi, Jeffrey T Guptill, +2 authors, Panos Stathopoulos, Richard J Nowak, Kevin C O'Connor. less Muscle Nerve, 2017 Sep 25; 57(2). PMID: 28940642 Free PMC article. Review.
Nanomaterials for cancer immunotherapy. Wantong Song, Sara N Musetti, Leaf Huang. Biomaterials, 2017 Sep 30; 148. PMID: 28961532 Free PMC article. Review.
Lambda phage-based vaccine induces antitumor immunity in hepatocellular carcinoma. Yoshifumi Iwagami, Sarah Casulli, +10 authors, Jack R Wands. less Heliyon, 2017 Oct 04; 3(9). PMID: 28971150 Free PMC article.
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Scott Gettinger, Jungmin Choi, +23 authors, Katerina Politi. less Cancer Discov, 2017 Oct 14; 7(12). PMID: 29025772 Free PMC article. Highly Cited.
Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma. Hyein Ahn, Jeong Mi Yang, +4 authors, Jin Ho Paik. less Oncotarget, 2017 Oct 17; 8(39). PMID: 29029502 Free PMC article.
Expression of PD-1 and PD-L1 in poorly differentiated neuroendocrine carcinomas of the digestive system: a potential target for anti-PD-1/PD-L1 therapy. Jordan A Roberts, Raul S Gonzalez, +2 authors, Satya Das, Jordan Berlin, Chanjuan Shi. less Hum Pathol, 2017 Oct 19; 70. PMID: 29037958 Free PMC article.
Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer. Yohei Masugi, Reiko Nishihara, +22 authors, Shuji Ogino. less Cancer Immunol Res, 2017 Oct 19; 5(11). PMID: 29038297 Free PMC article.
Identification and Validation of a PD-L1 Binding Peptide for Determination of PDL1 Expression in Tumors. Charles Caldwell, Cory E Johnson, +3 authors, Raghuraman Kannan. less Sci Rep, 2017 Oct 24; 7(1). PMID: 29057919 Free PMC article.
Cardiovascular Immunotherapy and the Role of Imaging. Eva Zupančič, Zahi A Fayad, Willem J M Mulder. Arterioscler Thromb Vasc Biol, 2017 Oct 27; 37(11). PMID: 29070539 Free PMC article. Review.
Resistance to checkpoint blockade therapy through inactivation of antigen presentation. Moshe Sade-Feldman, Yunxin J Jiao, +28 authors, Nir Hacohen. less Nat Commun, 2017 Oct 27; 8(1). PMID: 29070816 Free PMC article. Highly Cited.
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Tomasz Maj, Wei Wang, +11 authors, Weiping Zou. less Nat Immunol, 2017 Oct 31; 18(12). PMID: 29083399 Free PMC article. Highly Cited.
Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway. Ming Jing Shen, Li Jun Xu, +5 authors, Yuhchyau Chen. less Oncotarget, 2017 Nov 09; 8(46). PMID: 29113321 Free PMC article.
Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade. Haoran Zha, Xiao Han, +5 authors, Bo Zhu. less Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123963 Free PMC article.
Immune Analysis of Radium-223 in Patients With Metastatic Prostate Cancer. Joseph W Kim, Min Sun Shin, +2 authors, Youna Kang, Insoo Kang, Daniel P Petrylak. less Clin Genitourin Cancer, 2017 Nov 16; 16(2). PMID: 29137877 Free PMC article.
Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Jin Lee, Rui Liao, +7 authors, Gen-Sheng Feng. less Cell Rep, 2017 Nov 16; 21(7). PMID: 29141219 Free PMC article.
Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy. Yuchen Fan, Rui Kuai, +3 authors, James J Moon. less Nano Lett, 2017 Nov 17; 17(12). PMID: 29144754 Free PMC article.
Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Houjun Xia, Wei Wang, +12 authors, Weiping Zou. less Sci Immunol, 2017 Nov 19; 2(17). PMID: 29150439 Free PMC article.
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Jinfang Zhang, Xia Bu, +15 authors, Wenyi Wei. less Nature, 2017 Nov 22; 553(7686). PMID: 29160310 Free PMC article. Highly Cited.
B7-H1 Influences the Accumulation of Virus-Specific Tissue Resident Memory T Cells in the Central Nervous System. Kevin D Pavelko, Michael P Bell, Susan M Harrington, Haidong Dong. Front Immunol, 2017 Nov 25; 8. PMID: 29170671 Free PMC article.
Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma. Wojciech K Panek, J Robert Kane, +4 authors, Maciej S Lesniak. less Oncotarget, 2017 Nov 29; 8(51). PMID: 29179527 Free PMC article. Review.
Immunotherapy in metastatic urothelial carcinoma: focus on immune checkpoint inhibition. Arlene Siefker-Radtke, Brendan Curti. Nat Rev Urol, 2017 Dec 06; 15(2). PMID: 29205200 Review.
Phenotype and tissue distribution of CD28H+ immune cell subsets. Joel Crespo, Linda Vatan, +3 authors, Weiping Zou. less Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209568 Free PMC article.
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy. Robert J Torphy, Richard D Schulick, Yuwen Zhu. Int J Mol Sci, 2017 Dec 07; 18(12). PMID: 29211042 Free PMC article. Review.
Significant benefit of Nivolumab treating PD-L1 positive metastatic pulmonary carcinosarcoma: a case report and literature review. Zhe Zhang, Yishan Chen, +9 authors, Mingfang Zhao. less Oncotarget, 2017 Dec 10; 8(56). PMID: 29221220 Free PMC article.
Co-relation of overall survival with peripheral blood-based inflammatory biomarkers in advanced stage non-small cell lung cancer treated with anti-programmed cell death-1 therapy: results from a single institutional database. Abdul Rafeh Naqash, Chipman Robert Geoffrey Stroud, +7 authors, Paul R Walker. less Acta Oncol, 2017 Dec 16; 57(6). PMID: 29241410 Free PMC article.
Expression and clinical value of programmed cell death-ligand 1 (PD-L1) in diffuse large B cell lymphoma: a retrospective study. Li-Yang Hu, Xiao-Lu Xu, +7 authors, Qing-Qing Cai. less Chin J Cancer, 2017 Dec 17; 36(1). PMID: 29246182 Free PMC article.
PD-L1 Promotes Self-Renewal and Tumorigenicity of Malignant Melanoma Initiating Cells. Fang Zheng, Jianzhong Dang, +3 authors, Hui Zha, Bingyu Zhang, Ming Lin, Fanjun Cheng. less Biomed Res Int, 2017 Dec 19; 2017. PMID: 29250533 Free PMC article.
Preclinical and clinical development of neoantigen vaccines. L Li, S P Goedegebuure, W E Gillanders. Ann Oncol, 2017 Dec 19; 28(suppl_12). PMID: 29253113 Free PMC article. Review.
Tumor-associated macrophages-additional effectors at anti-PD-1/PD-L1 therapy? Kenichi Suda. J Thorac Dis, 2017 Dec 23; 9(11). PMID: 29268470 Free PMC article.
Recent Successes and Future Directions in Immunotherapy of Cutaneous Melanoma. Hassan Sadozai, Thomas Gruber, Robert Emil Hunger, Mirjam Schenk. Front Immunol, 2017 Dec 26; 8. PMID: 29276510 Free PMC article. Review.
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models. Katherine E Lewis, Mark J Selby, +11 authors, Stacey R Dillon. less Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296539 Free PMC article.
PD-1 related transcriptome profile and clinical outcome in diffuse gliomas. Shuai Liu, Zheng Wang, +5 authors, Tao Jiang. less Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308304 Free PMC article.
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. Marco Bezzi, Nina Seitzer, +11 authors, Pier Paolo Pandolfi. less Nat Med, 2018 Jan 09; 24(2). PMID: 29309058 Highly Cited.
Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy. Misako Matsumoto, Yohei Takeda, Megumi Tatematsu, Tsukasa Seya. Front Immunol, 2018 Jan 10; 8. PMID: 29312355 Free PMC article. Review.
Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. S Alivernini, B Tolusso, +3 authors, I B McInnes. less Clin Exp Immunol, 2018 Jan 10; 193(1). PMID: 29315512 Free PMC article. Review.
Cell Membrane Bioconjugation and Membrane-Derived Nanomaterials for Immunotherapy. Peter Y Li, Zhiyuan Fan, Hao Cheng. Bioconjug Chem, 2018 Jan 13; 29(3). PMID: 29323870 Free PMC article. Review.
PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression. Haidong Tang, Yong Liang, +18 authors, Yang-Xin Fu. less J Clin Invest, 2018 Jan 18; 128(2). PMID: 29337303 Free PMC article. Highly Cited.
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression. Heng Lin, Shuang Wei, +16 authors, Weiping Zou. less J Clin Invest, 2018 Jan 18; 128(2). PMID: 29337305 Free PMC article. Highly Cited.
High number of PD-1 positive intratumoural lymphocytes predicts survival benefit of cytokine-induced killer cells for hepatocellular carcinoma patients. Boyang Chang, Lujun Shen, +5 authors, Peihong Wu. less Liver Int, 2018 Jan 23; 38(8). PMID: 29356308 Free PMC article.
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations. Jun Gong, Alexander Chehrazi-Raffle, Srikanth Reddi, Ravi Salgia. J Immunother Cancer, 2018 Jan 24; 6(1). PMID: 29357948 Free PMC article. Highly Cited. Review.
PD-L1 and Emerging Biomarkers in Immune Checkpoint Blockade Therapy. Tricia R Cottrell, Janis M Taube. Cancer J, 2018 Jan 24; 24(1). PMID: 29360727 Free PMC article. Review.
Mechanisms of Resistance to PD-1 and PD-L1 Blockade. Theodore S Nowicki, Siwen Hu-Lieskovan, Antoni Ribas. Cancer J, 2018 Jan 24; 24(1). PMID: 29360728 Free PMC article. Highly Cited. Review.
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Tamas Fulop, Anis Larbi, +5 authors, Claudio Franceschi. less Front Immunol, 2018 Jan 30; 8. PMID: 29375577 Free PMC article. Highly Cited. Review.
Inhibition of the checkpoint protein PD-1 by the therapeutic antibody pembrolizumab outlined by quantum chemistry. Ana Beatriz M L A Tavares, José X Lima Neto, Umberto L Fulco, Eudenilson L Albuquerque. Sci Rep, 2018 Feb 01; 8(1). PMID: 29382901 Free PMC article.
Colorectal cancer prevention: Immune modulation taking the stage. Rochelle Fletcher, Yi-Jun Wang, +3 authors, Lin Zhang. less Biochim Biophys Acta Rev Cancer, 2018 Feb 03; 1869(2). PMID: 29391185 Free PMC article. Review.
PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse. Bingxin Zheng, Tingting Ren, +5 authors, Wei Guo. less J Hematol Oncol, 2018 Feb 08; 11(1). PMID: 29409495 Free PMC article. Highly Cited.
HLA class I loss and PD-L1 expression in lung cancer: impact on T-cell infiltration and immune escape. Francisco Perea, Abel Sánchez-Palencia, +9 authors, Natalia Aptsiauri. less Oncotarget, 2018 Feb 10; 9(3). PMID: 29423109 Free PMC article.
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Degao Chen, Jing Xie, +14 authors, Bo Huang. less Nat Commun, 2018 Mar 02; 9(1). PMID: 29491374 Free PMC article. Highly Cited.
B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Ling Chen, Takeshi Azuma, +3 authors, Weiwei Yu, Xu Zheng, Liqun Luo, Lieping Chen. less Proc Natl Acad Sci U S A, 2018 Mar 07; 115(12). PMID: 29507197 Free PMC article.
Cytokine-induced killer cells as a feasible adoptive immunotherapy for the treatment of lung cancer. Dan Chen, Huanhuan Sha, +10 authors, Jifeng Feng. less Cell Death Dis, 2018 Mar 08; 9(3). PMID: 29511158 Free PMC article.
The MYC oncogene is a global regulator of the immune response. Stephanie C Casey, Virginie Baylot, Dean W Felsher. Blood, 2018 Mar 09; 131(18). PMID: 29514782 Free PMC article. Review.
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis. Constantinos Roufas, Dimitrios Chasiotis, +3 authors, Apostolos Zaravinos. less Front Oncol, 2018 Mar 09; 8. PMID: 29515971 Free PMC article.
Molecular Mechanisms and Emerging Therapeutic Targets of Triple-Negative Breast Cancer Metastasis. Christiana Neophytou, Panagiotis Boutsikos, Panagiotis Papageorgis. Front Oncol, 2018 Mar 10; 8. PMID: 29520340 Free PMC article. Highly Cited. Review.
Engineering Vaccines to Reprogram Immunity against Head and Neck Cancer. Y S Tan, K Sansanaphongpricha, +3 authors, M E P Prince, D Sun, G T Wolf, Y L Lei. less J Dent Res, 2018 Mar 14; 97(6). PMID: 29533731 Free PMC article. Review.
Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells. Emilia Vendelova, Diyaaeldin Ashour, +4 authors, Manfred B Lutz. less Front Immunol, 2018 Mar 16; 9. PMID: 29541071 Free PMC article. Review.
Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. Naoto Nishii, Hidetake Tachinami, +8 authors, Miyuki Azuma. less Oncotarget, 2018 Mar 24; 9(17). PMID: 29568358 Free PMC article.
Prognostic value of PD-L1 in esophageal squamous cell carcinoma: a meta-analysis. Wei Guo, Pan Wang, +6 authors, Jie He. less Oncotarget, 2018 Mar 24; 9(17). PMID: 29568405 Free PMC article.
Mechanistic insights into cancer immunity and immunotherapy. Weiping Zou. Cell Mol Immunol, 2018 Mar 25; 15(5). PMID: 29572549 Free PMC article.
EP4 as a Therapeutic Target for Aggressive Human Breast Cancer. Mousumi Majumder, Pinki Nandi, +2 authors, Peeyush K Lala. less Int J Mol Sci, 2018 Mar 30; 19(4). PMID: 29596308 Free PMC article. Review.
Oncogenic Signaling Pathways and Pathway-Based Therapeutic Biomarkers in Lymphoid Malignancies. Ruifang Sun, Jinfen Wang, Ken H Young. Crit Rev Oncog, 2017 Jan 01; 22(5-6). PMID: 29604930 Free PMC article. Review.
Low-dose decitabine enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by re-modulating the tumor microenvironment. Ganjun Yu, Yanfeng Wu, +4 authors, Tao Wan. less Cell Mol Immunol, 2018 Apr 07; 16(4). PMID: 29622799 Free PMC article.
Immunotherapy Plus Cryotherapy: Potential Augmented Abscopal Effect for Advanced Cancers. Joe Abdo, David L Cornell, Sumeet K Mittal, Devendra K Agrawal. Front Oncol, 2018 Apr 13; 8. PMID: 29644213 Free PMC article. Review.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations. Judith A Seidel, Atsushi Otsuka, Kenji Kabashima. Front Oncol, 2018 Apr 13; 8. PMID: 29644214 Free PMC article. Highly Cited. Review.
Increased vessel perfusion predicts the efficacy of immune checkpoint blockade. Xichen Zheng, Zhaoxu Fang, +17 authors, Yuhui Huang. less J Clin Invest, 2018 Apr 18; 128(5). PMID: 29664018 Free PMC article.
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Tingting Wang, Dangge Wang, +6 authors, Yaping Li. less Nat Commun, 2018 Apr 20; 9(1). PMID: 29670088 Free PMC article.
Elimination of established tumors with nanodisc-based combination chemoimmunotherapy. Rui Kuai, Wenmin Yuan, +5 authors, James J Moon. less Sci Adv, 2018 Apr 21; 4(4). PMID: 29675465 Free PMC article. Highly Cited.
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions. Tong Zhang, Xiaomin Song, +20 authors, Kang Li. less Cancer Immunol Immunother, 2018 Apr 25; 67(7). PMID: 29687231 Free PMC article.
Integrative Pharmacology: Advancing Development of Effective Immunotherapies. Mohammad Tabrizi, Daping Zhang, Vaishnavi Ganti, Glareh Azadi. AAPS J, 2018 Apr 29; 20(4). PMID: 29704129 Review.
Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway. Shaojia Wang, Jiajia Li, +7 authors, Xiaohua Wu. less Oncogene, 2018 May 01; 37(30). PMID: 29706653
Noninvasive PET Imaging of T cells. Weijun Wei, Dawei Jiang, +2 authors, Emily B Ehlerding, Quanyong Luo, Weibo Cai. less Trends Cancer, 2018 May 02; 4(5). PMID: 29709260 Free PMC article. Review.
The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update. Semir Vranic, Farhan Sachal Cyprian, Saghir Akhtar, Ala-Eddin Al Moustafa. Front Oncol, 2018 May 03; 8. PMID: 29719817 Free PMC article. Review.
Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells. Sonja Lieber, Silke Reinartz, +8 authors, Magdalena Huber. less Oncoimmunology, 2018 May 04; 7(5). PMID: 29721385 Free PMC article.
M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine. Karin M Knudson, Kristin C Hicks, +3 authors, Sofia R Gameiro. less Oncoimmunology, 2018 May 04; 7(5). PMID: 29721396 Free PMC article. Highly Cited.
B7-H1 Expression Is Required for Human Endometrial Regenerative Cells in the Prevention of Transplant Vasculopathy in Mice. Kui Ye, Xu Lan, +5 authors, Hao Wang. less Stem Cells Int, 2018 May 08; 2018. PMID: 29731774 Free PMC article.
YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting. Federica Lo Sardo, Sabrina Strano, Giovanni Blandino. Cancers (Basel), 2018 May 08; 10(5). PMID: 29734788 Free PMC article. Review.
Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy? Fei Tang, Pan Zheng. Cell Biosci, 2018 May 11; 8. PMID: 29744030 Free PMC article.
T Follicular Regulatory Cells and Antibody Responses in Transplantation. Elizabeth F Wallin. Transplantation, 2018 May 15; 102(10). PMID: 29757907 Free PMC article. Review.
STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Jung-Mao Hsu, Weiya Xia, +14 authors, Mien-Chie Hung. less Nat Commun, 2018 May 17; 9(1). PMID: 29765039 Free PMC article. Highly Cited.
Defining and Understanding Adaptive Resistance in Cancer Immunotherapy. Tae Kon Kim, Roy S Herbst, Lieping Chen. Trends Immunol, 2018 May 29; 39(8). PMID: 29802087 Free PMC article. Highly Cited. Review.
Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer. Wei Li, Takashi Tanikawa, +15 authors, Weiping Zou. less Cell Metab, 2018 May 29; 28(1). PMID: 29805099 Free PMC article. Highly Cited.
Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens. Mengjia Song, Xinfeng Chen, Liping Wang, Yi Zhang. Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861603 Free PMC article.
Multiplex bead-based measurement of humoral immune responses against tumor-associated antigens in stage II melanoma patients of the EORTC18961 trial. Judith Michels, Natalia Becker, +11 authors, Inka Zörnig. less Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872552 Free PMC article.
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap. Wantong Song, Limei Shen, +7 authors, Leaf Huang. less Nat Commun, 2018 Jun 10; 9(1). PMID: 29884866 Free PMC article. Highly Cited.
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade. Daniela S Thommen, Viktor H Koelzer, +16 authors, Alfred Zippelius. less Nat Med, 2018 Jun 13; 24(7). PMID: 29892065 Free PMC article. Highly Cited.
PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study. Giulia Bertolini, Luca Bergamaschi, +11 authors, Patrizia Gasparini. less BMC Cancer, 2018 Jun 15; 18(1). PMID: 29898687 Free PMC article.
Dynamic change of PD-L1 expression on circulating tumor cells in advanced solid tumor patients undergoing PD-1 blockade therapy. Chunyan Yue, Yubo Jiang, +9 authors, Jianming Xu. less Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900038 Free PMC article. Highly Cited.
CD133-directed CAR T cells for advanced metastasis malignancies: A phase I trial. Yao Wang, Meixia Chen, +11 authors, Weidong Han. less Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900044 Free PMC article. Highly Cited.
Tumor Regression and Cure Depends on Sustained Th1 Responses. Min Dai, Ingegerd Hellstrom, +2 authors, Yuen Y Yip, Hans Olov Sjögren, Karl Erik Hellstrom. less J Immunother, 2018 Jun 19; 41(8). PMID: 29912725 Free PMC article.
Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma. Chao-Qun Liu, Jing Xu, +7 authors, Limin Zheng. less Br J Cancer, 2018 Jun 21; 119(1). PMID: 29921949 Free PMC article.
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Wanqiang Sheng, Martin W LaFleur, +13 authors, Yang Shi. less Cell, 2018 Jun 26; 174(3). PMID: 29937226 Free PMC article. Highly Cited.
Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Yi Yang, Chia-Wei Li, +8 authors, Mien-Chie Hung. less Cell Res, 2018 Jul 01; 28(8). PMID: 29959401 Free PMC article. Highly Cited.
Harmonization of PD-L1 testing in oncology: a Canadian pathology perspective. D N Ionescu, M R Downes, A Christofides, M S Tsao. Curr Oncol, 2018 Jul 03; 25(3). PMID: 29962847 Free PMC article. Review.
Active Role of the Necrotic Zone in Desensitization of Hypoxic Macrophages and Regulation of CSC-Fate: A hypothesis. Maryam Mehrabi, Fatemeh Amini, Shima Mehrabi. Front Oncol, 2018 Jul 11; 8. PMID: 29988496 Free PMC article.
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Yunlong Zhao, Devin L Harrison, +3 authors, Yuran Song, Jie Ji, Jun Huang, Enfu Hui. less Cell Rep, 2018 Jul 12; 24(2). PMID: 29996099 Free PMC article.
Safety and efficacy of durvalumab (MEDI4736) in various solid tumors. Hui Yang, Kai Shen, +3 authors, Xuelei Ma. less Drug Des Devel Ther, 2018 Jul 18; 12. PMID: 30013326 Free PMC article.
Interferon gamma in cancer immunotherapy. Ling Ni, Jian Lu. Cancer Med, 2018 Jul 25; 7(9). PMID: 30039553 Free PMC article. Highly Cited. Review.
Beneficial and Paradoxical Roles of Anti-Oxidative Nutritional Support for Non-Alcoholic Fatty Liver Disease. Daisuke Uchida, Akinobu Takaki, Takuya Adachi, Hiroyuki Okada. Nutrients, 2018 Aug 01; 10(8). PMID: 30060482 Free PMC article. Review.
Activation of phagocytosis by immune checkpoint blockade. Chia-Wei Li, Yun-Ju Lai, Jennifer L Hsu, Mien-Chie Hung. Front Med, 2018 Aug 01; 12(4). PMID: 30062558 Free PMC article. Review.
Comparison of Microbiota in Patients Treated by Surgery or Chemotherapy by 16S rRNA Sequencing Reveals Potential Biomarkers for Colorectal Cancer Therapy. Xingming Deng, Zhuofei Li, +3 authors, Guan Li, Bei Li, Xinhan Jin, Guoqing Lyu. less Front Microbiol, 2018 Aug 02; 9. PMID: 30065719 Free PMC article.
Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling. Justin Lucas, Tze-Chen Hsieh, +2 authors, Joseph M Wu. less Int J Oncol, 2018 Aug 02; 53(4). PMID: 30066852 Free PMC article.
Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody. Kyoko Yamaguchi, Koji Mishima, +12 authors, Eishi Baba. less Cancer Sci, 2018 Aug 02; 109(10). PMID: 30066977 Free PMC article.
White paper on microbial anti-cancer therapy and prevention. Neil S Forbes, Robert S Coffin, +20 authors, Grant McFadden. less J Immunother Cancer, 2018 Aug 08; 6(1). PMID: 30081947 Free PMC article. Review.
Checkpoint blockade-based immunotherapy in the context of tumor microenvironment: Opportunities and challenges. Jingjing Duan, Yu Wang, Shunchang Jiao. Cancer Med, 2018 Aug 09; 7(9). PMID: 30088347 Free PMC article. Review.
CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas. Xiudong Guan, Chuanbao Zhang, +3 authors, Wang Jia. less EBioMedicine, 2018 Aug 23; 35. PMID: 30131308 Free PMC article.
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance. Young-Jun Park, Da-Sol Kuen, Yeonseok Chung. Exp Mol Med, 2018 Aug 24; 50(8). PMID: 30135516 Free PMC article. Highly Cited. Review.
Topoisomerase I inhibitor, irinotecan, depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression, resulting in a supra-additive antitumor effect when combined with anti-PD-L1 antibodies. Toshiki Iwai, Masamichi Sugimoto, +3 authors, Kaname Yamamoto. less Oncotarget, 2018 Aug 25; 9(59). PMID: 30140379 Free PMC article.
Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1. Yu-Tzu Tai, Shih-Feng Cho, Kenneth C Anderson. Front Immunol, 2018 Aug 28; 9. PMID: 30147691 Free PMC article. Review.
Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice. Ying Wang, Lijing Su, +17 authors, Bruce Beutler. less Proc Natl Acad Sci U S A, 2018 Aug 29; 115(37). PMID: 30150374 Free PMC article.
Chemotherapeutic Treatments Increase PD-L1 Expression in Esophageal Squamous Cell Carcinoma through EGFR/ERK Activation. Hoi Yan Ng, Jian Li, +7 authors, Maria Li Lung. less Transl Oncol, 2018 Sep 03; 11(6). PMID: 30172884 Free PMC article.
Tumor-infiltrating T cells in epithelial ovarian cancer: predictors of prognosis and biological basis of immunotherapy. Weimin Wang, Weiping Zou, J Rebecca Liu. Gynecol Oncol, 2018 Sep 24; 151(1). PMID: 30243508 Free PMC article.
Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer. Yihao Mao, Qingyang Feng, +10 authors, Jianmin Xu. less Cancer Manag Res, 2018 Oct 03; 10. PMID: 30271205 Free PMC article.
Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy. Jinfang Zhang, Fabin Dang, Junming Ren, Wenyi Wei. Trends Biochem Sci, 2018 Oct 06; 43(12). PMID: 30287140 Free PMC article. Review.
Combination with SGT-53 overcomes tumor resistance to a checkpoint inhibitor. Sang-Soo Kim, Joe B Harford, +2 authors, Manish Moghe, Antonina Rait, Esther H Chang. less Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288347 Free PMC article.
Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences. Xinyu Yan, Shouyue Zhang, +3 authors, Yun Deng, Peiqi Wang, Qianqian Hou, Heng Xu. less Front Pharmacol, 2018 Oct 09; 9. PMID: 30294272 Free PMC article. Review.
Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1). Marcin Kowanetz, Wei Zou, +27 authors, Priti S Hegde. less Proc Natl Acad Sci U S A, 2018 Oct 10; 115(43). PMID: 30297397 Free PMC article. Highly Cited.
Biosynthetic energy cost for amino acids decreases in cancer evolution. Hong Zhang, Yirong Wang, +5 authors, Jian Lu. less Nat Commun, 2018 Oct 10; 9(1). PMID: 30297703 Free PMC article.
The Protein Expression of PDL1 Is Highly Correlated with Those of eIF2α and ATF4 in Lung Cancer. Liang-Che Chang, Tzu-Ping Chen, Wei-Ke Kuo, Chung-Ching Hua. Dis Markers, 2018 Oct 12; 2018. PMID: 30305853 Free PMC article.
Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity. Gianluca D'Agostino, Valentina Cecchinato, Mariagrazia Uguccioni. Front Immunol, 2018 Oct 16; 9. PMID: 30319638 Free PMC article. Review.
Programmed death ligand 1 expression in human intrahepatic cholangiocarcinoma and its association with prognosis and CD8+ T-cell immune responses. Ying Zhu, Xiang-Yu Wang, +6 authors, Xin Yang. less Cancer Manag Res, 2018 Oct 17; 10. PMID: 30323667 Free PMC article.
Multimodal detection of PD-L1: reasonable biomarkers for immune checkpoint inhibitor. Qiao Yang, Zihan Xu, +3 authors, Jianguo Sun. less Am J Cancer Res, 2018 Oct 17; 8(9). PMID: 30323963 Free PMC article. Review.
Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity. Farideh Ordikhani, Mayuko Uehara, +12 authors, Reza Abdi. less JCI Insight, 2018 Oct 20; 3(20). PMID: 30333312 Free PMC article.
Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects. Lu Xu, Yang Zhang, +13 authors, Han Liu. less J Exp Clin Cancer Res, 2018 Oct 31; 37(1). PMID: 30373602 Free PMC article.
Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types. Kristin C Hicks, Massimo Fantini, +10 authors, Sofia R Gameiro. less Oncoimmunology, 2018 Nov 01; 7(11). PMID: 30377559 Free PMC article.
Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance. Yong Liang, Haidong Tang, +12 authors, Yang-Xin Fu. less Nat Commun, 2018 Nov 06; 9(1). PMID: 30389912 Free PMC article.
An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion. John D Klement, Amy V Paschall, +7 authors, Kebin Liu. less J Clin Invest, 2018 Nov 06; 128(12). PMID: 30395540 Free PMC article.
A novel ternary heterostructure with dramatic SERS activity for evaluation of PD-L1 expression at the single-cell level. Enduo Feng, Tingting Zheng, +2 authors, Xiaoxiao He, Jinquan Chen, Yang Tian. less Sci Adv, 2018 Nov 09; 4(11). PMID: 30406203 Free PMC article.
Prognostic significance of programmed cell death ligand 1 expression in patients with ovarian carcinoma: A systematic review and meta-analysis. Li-Jun Huang, Xiao-Feng Deng, +3 authors, Fan Chang, Xian-Lan Wu, Yang Wu, Qi-Zhi Diao. less Medicine (Baltimore), 2018 Nov 10; 97(43). PMID: 30412078 Free PMC article. Systematic Review.
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy. Kebin Liu, Chunwan Lu. Transl Cancer Res, 2018 Nov 18; 7(Suppl 5). PMID: 30443490 Free PMC article.
Deep Semi Supervised Generative Learning for Automated Tumor Proportion Scoring on NSCLC Tissue Needle Biopsies. Ansh Kapil, Armin Meier, +4 authors, Nicolas Brieu. less Sci Rep, 2018 Nov 28; 8(1). PMID: 30478349 Free PMC article.
The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response. Andrea Devecchi, Loris De Cecco, +7 authors, Silvana Pilotti. less Cancer Commun (Lond), 2018 Nov 30; 38(1). PMID: 30486883 Free PMC article.
Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. Marcella Tazzari, Silvia Brich, +13 authors, Chiara Castelli. less J Immunol Res, 2018 Dec 05; 2018. PMID: 30510965 Free PMC article.
Impact of PD-L1 expression, driver mutations and clinical characteristics on survival after anti-PD-1/PD-L1 immunotherapy versus chemotherapy in non-small-cell lung cancer: A meta-analysis of randomized trials. Qingyuan Huang, Hua Zhang, +4 authors, Justin Stebbing. less Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524878 Free PMC article.
HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer. Rui Deng, Peng Zhang, +9 authors, Kaixiong Tao. less Clin Epigenetics, 2018 Dec 13; 10(1). PMID: 30537988 Free PMC article.
Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides. Jun Nakata, Hiroko Nakajima, +12 authors, Haruo Sugiyama. less Oncotarget, 2018 Dec 14; 9(89). PMID: 30542516 Free PMC article.
Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma. Lukas W Pfannenstiel, Corey McNeilly, +4 authors, Brian R Gastman. less Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546944 Free PMC article.
Soluble programmed death-1 is a useful indicator for inflammatory and fibrosis severity in chronic hepatitis B. Liang Zhou, Xiaoyan Li, +3 authors, Xiaohui Huang, Lubiao Chen, Lin Gu, Yuehua Huang. less J Viral Hepat, 2018 Dec 24; 26(7). PMID: 30578715 Free PMC article.
Fates of CD8+ T cells in Tumor Microenvironment. Nomathamsanqa Resegofetse Maimela, Shasha Liu, Yi Zhang. Comput Struct Biotechnol J, 2018 Dec 26; 17. PMID: 30581539 Free PMC article. Highly Cited. Review.
Role of B7H3/IL-33 Signaling in Pulmonary Fibrosis-induced Profibrogenic Alterations in Bone Marrow. Taku Nakashima, Tianju Liu, +6 authors, Sem H Phan. less Am J Respir Crit Care Med, 2019 May 21; 200(8). PMID: 31106564 Free PMC article.
Phage display screening of therapeutic peptide for cancer targeting and therapy. Phei Er Saw, Er-Wei Song. Protein Cell, 2019 May 30; 10(11). PMID: 31140150 Free PMC article. Review.
Application of PD-1 Blockade in Cancer Immunotherapy. Xiaomo Wu, Zhongkai Gu, +4 authors, Xiaolong Liu. less Comput Struct Biotechnol J, 2019 Jun 18; 17. PMID: 31205619 Free PMC article. Highly Cited. Review.
Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology. Gabriele Di Sante, Jessica Pagé, +4 authors, Richard G Pestell. less Expert Rev Anticancer Ther, 2019 Jun 21; 19(7). PMID: 31219365 Free PMC article. Review.
A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma. Sang-Soo Kim, Joe B Harford, +3 authors, Esther H Chang. less Int J Cancer, 2019 Jun 27; 145(9). PMID: 31241175 Free PMC article.
Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy. Heng-Huan Lee, Ying-Nai Wang, +15 authors, Mien-Chie Hung. less Cancer Cell, 2019 Jul 23; 36(2). PMID: 31327656 Free PMC article. Highly Cited.
Comprehensive immune characterization and T-cell receptor repertoire heterogeneity of retroperitoneal liposarcoma. Liang Yan, Zhen Wang, +6 authors, Chunyi Hao. less Cancer Sci, 2019 Aug 07; 110(10). PMID: 31385405 Free PMC article.
The clinicopathological and prognostic value of PD-L1 in urothelial carcinoma: a meta-analysis. Yaoan Wen, Yeda Chen, +4 authors, Guohua Zeng. less Clin Exp Med, 2019 Aug 14; 19(4). PMID: 31407099 Review.
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity. Zining Wang, Jiemin Chen, +13 authors, Xiaojun Xia. less J Clin Invest, 2019 Aug 14; 129(11). PMID: 31408442 Free PMC article.
Programmed Cell Death Ligand 1 in Breast Cancer: Technical Aspects, Prognostic Implications, and Predictive Value. Federica Miglietta, Gaia Griguolo, Valentina Guarneri, Maria Vittoria Dieci. Oncologist, 2019 Aug 25; 24(11). PMID: 31444294 Free PMC article. Review.
Circulating biomarkers predictive of tumor response to cancer immunotherapy. Ernest Y Lee, Rajan P Kulkarni. Expert Rev Mol Diagn, 2019 Aug 31; 19(10). PMID: 31469965 Free PMC article. Review.
BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response. Guillaume P Andrieu, Jordan S Shafran, +4 authors, Gerald V Denis. less Cancer Lett, 2019 Sep 02; 465. PMID: 31473251 Free PMC article.
Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development. Peng Tan, Lian He, +9 authors, Rong-Fu Wang. less J Clin Invest, 2019 Sep 11; 129(12). PMID: 31503548 Free PMC article.
αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion. Andrea Vannini, Valerio Leoni, +5 authors, Tatiana Gianni. less Proc Natl Acad Sci U S A, 2019 Sep 19; 116(40). PMID: 31527243 Free PMC article.
Blockade of PD-L1 Enhances Cancer Immunotherapy by Regulating Dendritic Cell Maturation and Macrophage Polarization. Nai-Yun Sun, Yu-Li Chen, +8 authors, Wen-Fang Cheng. less Cancers (Basel), 2019 Sep 25; 11(9). PMID: 31546897 Free PMC article.
Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression. Chloé Laplagne, Marcin Domagala, +7 authors, Mary Poupot. less Int J Mol Sci, 2019 Sep 25; 20(19). PMID: 31547627 Free PMC article. Review.
Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Xueting Lang, Michael D Green, +20 authors, Weiping Zou. less Cancer Discov, 2019 Sep 27; 9(12). PMID: 31554642 Free PMC article. Highly Cited.
In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles. Yeteng Zhong, Zhuoran Ma, +16 authors, Hongjie Dai. less Nat Biotechnol, 2019 Oct 02; 37(11). PMID: 31570897 Free PMC article.
Three discipline collaborative radiation therapy (3DCRT) special debate: The single most important factor in determining the future of SBRT is immune response. Clemens Grassberger, Kathryn Huber, +6 authors, Jay Burmeister. less J Appl Clin Med Phys, 2019 Oct 02; 20(10). PMID: 31573143 Free PMC article.
HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma. Yangzhi Qi, Gang Deng, +6 authors, Qianxue Chen. less Oncol Rep, 2019 Oct 04; 42(6). PMID: 31578594 Free PMC article.
Classical Hodgkin's Lymphoma in the Era of Immune Checkpoint Inhibition. Valli De Re, Laura Caggiari, +2 authors, Ombretta Repetto, Lara Mussolin, Maurizio Mascarin. less J Clin Med, 2019 Oct 05; 8(10). PMID: 31581738 Free PMC article. Review.
Promising new treatments for pancreatic cancer in the era of targeted and immune therapies. Ahmed Elaileh, Ashish Saharia, +4 authors, Kirk Heyne. less Am J Cancer Res, 2019 Oct 11; 9(9). PMID: 31598392 Free PMC article. Review.
CAR-T 19 combined with reduced-dose PD-1 blockade therapy for treatment of refractory follicular lymphoma: A case report. Jia Wang, Qi Deng, +4 authors, Yu-Ming Li. less Oncol Lett, 2019 Oct 16; 18(5). PMID: 31611950 Free PMC article.
Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors. Giuseppe Schepisi, Nicole Brighi, +11 authors, Ugo De Giorgi. less J Oncol, 2019 Oct 24; 2019. PMID: 31641355 Free PMC article. Review.
Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method. Tal Flieswasser, Valérie Camara-Clayette, +9 authors, Julie Jacobs. less Cancers (Basel), 2019 Oct 28; 11(10). PMID: 31652572 Free PMC article.
Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy. Liping Huang, Yanan Li, +8 authors, Chunmeng Sun. less Nat Commun, 2019 Oct 28; 10(1). PMID: 31653838 Free PMC article.
Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation. Mingzhu Wang, Junchao Wang, +4 authors, Min Zhang. less Commun Biol, 2019 Nov 02; 2. PMID: 31667366 Free PMC article.
Red blood cell-derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy. Xiao Han, Shufang Shen, +6 authors, Chao Wang. less Sci Adv, 2019 Nov 05; 5(10). PMID: 31681841 Free PMC article.
IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer. Guoping Ding, Tao Shen, +3 authors, Liping Cao. less BMC Cancer, 2019 Nov 07; 19(1). PMID: 31694582 Free PMC article.
PD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis. Chang E Gao, Ming Zhang, Qian Song, Jian Dong. Onco Targets Ther, 2019 Nov 07; 12. PMID: 31695411 Free PMC article.
Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer. Sehui Kim, Ji-Young Jang, +10 authors, Yoon Kyung Jeon. less J Exp Clin Cancer Res, 2019 Nov 14; 38(1). PMID: 31718692 Free PMC article.
Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells. Kankana Bardhan, Halil-Ibrahim Aksoylar, +6 authors, Vassiliki A Boussiotis. less Sci Rep, 2019 Nov 23; 9(1). PMID: 31754127 Free PMC article.
Fusobacterium nucleatum prevents apoptosis in colorectal cancer cells via the ANO1 pathway. Pei Lu, Minyi Xu, +2 authors, Zhongbo Xiong, Fangfang Zhou, Lei Wang. less Cancer Manag Res, 2019 Dec 06; 11. PMID: 31802939 Free PMC article.
From Super-Enhancer Non-coding RNA to Immune Checkpoint: Frameworks to Functions. Manqing Wu, Jun Shen. Front Oncol, 2019 Dec 12; 9. PMID: 31824865 Free PMC article. Review.
Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity. Lucien P Garo, Amrendra K Ajay, +8 authors, Gopal Murugaiyan. less Cell Rep, 2019 Sep 26; 28(13). PMID: 31553906 Free PMC article.
Reduced GRAMD1C expression correlates to poor prognosis and immune infiltrates in kidney renal clear cell carcinoma. Haiyan Hao, Ziheng Wang, +4 authors, Wei Wang. less PeerJ, 2019 Dec 26; 7. PMID: 31875150 Free PMC article.
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Yunlong Zhao, Calvin K Lee, +8 authors, Enfu Hui. less Immunity, 2019 Nov 24; 51(6). PMID: 31757674 Free PMC article.
PD-L1 Expression and Tumor-Infiltrating Lymphocytes in Thymic Epithelial Neoplasms. Rumi Higuchi, Taichiro Goto, +6 authors, Masao Omata. less J Clin Med, 2019 Nov 07; 8(11). PMID: 31683962 Free PMC article.
Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors. Wenyan Zhong, Jeremy S Myers, +11 authors, Paul A Rejto. less BMC Genomics, 2020 Jan 04; 21(1). PMID: 31898484 Free PMC article.
Evaluation of PD-L1 and PD-1 expression in aggressive eyelid sebaceous gland carcinoma and its clinical significance. Perumal Jayaraj, Seema Sen. Indian J Ophthalmol, 2019 Nov 23; 67(12). PMID: 31755433 Free PMC article.
Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment. Yangjing Zhao, Qixiang Shao, Guangyong Peng. Cell Mol Immunol, 2019 Dec 20; 17(1). PMID: 31853000 Free PMC article. Review.
Mechanisms Controlling PD-L1 Expression in Cancer. Jong-Ho Cha, Li-Chuan Chan, +2 authors, Chia-Wei Li, Jennifer L Hsu, Mien-Chie Hung. less Mol Cell, 2019 Nov 02; 76(3). PMID: 31668929 Free PMC article. Review.
Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma. Shogo Zuo, Masayuki Sho, +6 authors, Hiroomi Okuyama. less Pediatr Surg Int, 2020 Jan 12; 36(2). PMID: 31925505
Comprehensive Survey of Clinical Trials Registration for Melanoma Immunotherapy in the ClinicalTrials.gov. Yan-Bo Wang, Gang Lv, +2 authors, Feng-Hua Xu, Lin-Lu Ma, Yong-Ming Yao. less Front Pharmacol, 2020 Jan 31; 10. PMID: 31998135 Free PMC article.
B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models. Baozhu Huang, Liqun Luo, +6 authors, Gangxiong Huang. less Oncoimmunology, 2020 Feb 01; 9(1). PMID: 32002297 Free PMC article.
BTLA Expression in Stage I-III Non-Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes. Xiangmin Li, Zhaoguo Xu, +2 authors, Guoyuan Cui, Li Yu, Xiaoye Zhang. less Onco Targets Ther, 2020 Feb 06; 13. PMID: 32021268 Free PMC article.
Enhanced histone H3 acetylation of the PD-L1 promoter via the COP1/c-Jun/HDAC3 axis is required for PD-L1 expression in drug-resistant cancer cells. Haifang Wang, Chen Fu, +10 authors, Yurong Qiu. less J Exp Clin Cancer Res, 2020 Feb 07; 39(1). PMID: 32024543 Free PMC article.
Immunotherapy in Ovarian Cancer. Weimin Wang, Janice Rebecca Liu, Weiping Zou. Surg Oncol Clin N Am, 2019 May 14; 28(3). PMID: 31079799 Free PMC article. Review.
Is first-line pembrolizumab appropriate for all patients with metastatic non-squamous histology non-small cell lung cancer patients? Laura Le, Ritchell van Dams, Percy Lee. Transl Lung Cancer Res, 2020 Feb 11; 8(Suppl 4). PMID: 32038907 Free PMC article.
The Novel Combination of Nitroxoline and PD-1 Blockade, Exerts a Potent Antitumor Effect in a Mouse Model of Prostate Cancer. Naijin Xu, Linglong Huang, +9 authors, Peng Huang. less Int J Biol Sci, 2019 Jun 12; 15(5). PMID: 31182913 Free PMC article.
Immune Cell PD-L1 Colocalizes with Macrophages and Is Associated with Outcome in PD-1 Pathway Blockade Therapy. Yuting Liu, Jon Zugazagoitia, +5 authors, David L Rimm. less Clin Cancer Res, 2019 Oct 17; 26(4). PMID: 31615933 Free PMC article.
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Meike E W Logtenberg, J H Marco Jansen, +18 authors, Ton N Schumacher. less Nat Med, 2019 Mar 06; 25(4). PMID: 30833751 Free PMC article. Highly Cited.
Prevalence of NRAS Mutation, PD-L1 Expression and Amplification, and Overall Survival Analysis in 36 Primary Vaginal Melanomas. Hai-Yun Wang, Xiao-Yan Wu, +4 authors, Fang Wang. less Oncologist, 2020 Feb 12; 25(2). PMID: 32043781 Free PMC article.
Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors. Yuki Saito, Takako S Chikenji, +2 authors, Takashi Matsumura, Masako Nakano, Mineko Fujimiya. less Nat Commun, 2020 Feb 16; 11(1). PMID: 32060352 Free PMC article.
Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment. Ya Luo, Jiqiao Yang, +5 authors, Xuelei Ma. less Front Oncol, 2020 Feb 23; 10. PMID: 32083005 Free PMC article. Review.
Establishment of humanized tumor microenvironment mouse models based on the injection of peripheral blood mononuclear cells and IFN-γ to evaluate the efficacy of PD-L1/PD-1-targeted immunotherapy. Xiuyun Lin, Tao Zeng, +7 authors, Jizhen Lin. less Cancer Biol Ther, 2019 Nov 07; 21(2). PMID: 31690181 Free PMC article.
Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy. Guojun Chen, Zhitong Chen, +6 authors, Zhen Gu. less Proc Natl Acad Sci U S A, 2020 Feb 08; 117(7). PMID: 32029590 Free PMC article.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer. Takahiro Kamada, Yosuke Togashi, +13 authors, Hiroyoshi Nishikawa. less Proc Natl Acad Sci U S A, 2019 Apr 28; 116(20). PMID: 31028147 Free PMC article. Highly Cited.
A comparative characterization of the circulating miRNome in whole blood and serum of HCC patients. Devis Pascut, Helena Krmac, +4 authors, Claudio Tiribelli. less Sci Rep, 2019 Jun 06; 9(1). PMID: 31164669 Free PMC article.
Therapeutic PD-L1 antibodies are more effective than PD-1 antibodies in blocking PD-1/PD-L1 signaling. Annika De Sousa Linhares, Claire Battin, +8 authors, Peter Steinberger. less Sci Rep, 2019 Aug 09; 9(1). PMID: 31391510 Free PMC article.
Resistance to Checkpoint Inhibition in Cancer Immunotherapy. Luisa Barrueto, Francheska Caminero, +3 authors, Rahul R Deshmukh. less Transl Oncol, 2020 Mar 03; 13(3). PMID: 32114384 Free PMC article. Review.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy. Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han. J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595 Free PMC article. Highly Cited. Review.
Distinct contribution of PD-L1 suppression by spatial expression of PD-L1 on tumor and non-tumor cells. Xiaoqing Zhang, Chen Cheng, +4 authors, Xuanming Yang. less Cell Mol Immunol, 2018 Mar 24; 16(4). PMID: 29568117 Free PMC article.
PD-1 blocks lytic granule polarization with concomitant impairment of integrin outside-in signaling in the natural killer cell immunological synapse. Yu Huang, Zhiying Chen, +10 authors, Dongfang Liu. less J Allergy Clin Immunol, 2018 Apr 22; 142(4). PMID: 29679656 Free PMC article.
S100B and LDH as early prognostic markers for response and overall survival in melanoma patients treated with anti-PD-1 or combined anti-PD-1 plus anti-CTLA-4 antibodies. Nikolaus B Wagner, Andrea Forschner, +2 authors, Ulrike Leiter, Claus Garbe, Thomas K Eigentler. less Br J Cancer, 2018 Jun 29; 119(3). PMID: 29950611 Free PMC article.
Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy. Xiaolei Li, Wenhui Song, +2 authors, Changshun Shao, Yufang Shi, Weidong Han. less Cell Mol Immunol, 2018 Jul 14; 16(1). PMID: 30002451 Free PMC article. Review.
Regulation of NK-Cell Function by HLA Class II. Annika Niehrs, Marcus Altfeld. Front Cell Infect Microbiol, 2020 Mar 07; 10. PMID: 32133304 Free PMC article.
Loss of VGLL4 suppresses tumor PD-L1 expression and immune evasion. Ailing Wu, Qingzhe Wu, +7 authors, Hai Song. less EMBO J, 2018 Nov 07; 38(1). PMID: 30396996 Free PMC article.
Spatial and phenotypic immune profiling of metastatic colon cancer. Jenny Lazarus, Tomasz Maj, +15 authors, Timothy L Frankel. less JCI Insight, 2018 Nov 16; 3(22). PMID: 30429368 Free PMC article.
Immune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinoma. M Oliva, A Spreafico, +4 authors, L L Siu. less Ann Oncol, 2018 Nov 22; 30(1). PMID: 30462163 Free PMC article. Review.
Pre- and post-operative anti-PD-L1 plus anti-angiogenic therapies in mouse breast or renal cancer models of micro- or macro-metastatic disease. Florence T H Wu, Ping Xu, +6 authors, Robert S Kerbel. less Br J Cancer, 2018 Dec 01; 120(2). PMID: 30498230 Free PMC article.
Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. Hye-Yeong Kim, Ran Li, +8 authors, Miles A Miller. less ACS Nano, 2018 Dec 07; 12(12). PMID: 30508377 Free PMC article.
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer. Weihua Hou, Qingyun Yuan, +4 authors, Min Yu. less Invest New Drugs, 2018 Dec 05; 37(5). PMID: 30511201
Palmitoylation stabilizes PD-L1 to promote breast tumor growth. Yi Yang, Jung-Mao Hsu, +8 authors, Mien-Chie Hung. less Cell Res, 2018 Dec 06; 29(1). PMID: 30514902 Free PMC article.
Modulating the Tumor Microenvironment via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy. Gang Shi, Qianmei Yang, +21 authors, Hongxin Deng. less Mol Ther, 2018 Dec 12; 27(1). PMID: 30527756 Free PMC article.
Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4). N Boku, M-H Ryu, +13 authors, Y-K Kang. less Ann Oncol, 2018 Dec 20; 30(2). PMID: 30566590 Free PMC article. Highly Cited.
Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement. Douglas B Johnson, Mellissa J Nixon, +21 authors, Justin M Balko. less JCI Insight, 2018 Dec 21; 3(24). PMID: 30568030 Free PMC article.
Combined α-programmed death-1 monoclonal antibody blockade and fractionated radiation therapy reduces tumor growth in mouse EL4 lymphoma. Xiuyun Lin, Tao Zeng, +19 authors, Jizhen Lin. less Cancer Biol Ther, 2018 Dec 24; 20(5). PMID: 30572778 Free PMC article.
Immune-checkpoint inhibitor plus chemotherapy versus conventional chemotherapy for first-line treatment in advanced non-small cell lung carcinoma: a systematic review and meta-analysis. Yixin Zhou, Chen Chen, +10 authors, Li Zhang. less J Immunother Cancer, 2018 Dec 24; 6(1). PMID: 30577837 Free PMC article. Systematic Review.
Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance. Daisuke Muraoka, Naohiro Seo, +17 authors, Hiroshi Shiku. less J Clin Invest, 2019 Jan 11; 129(3). PMID: 30628894 Free PMC article.
Tumor-Targeted Chemoimmunotherapy with Immune-Checkpoint Blockade for Enhanced Anti-Melanoma Efficacy. Man Li, Yuting Yang, +8 authors, Qin He. less AAPS J, 2019 Jan 13; 21(2). PMID: 30635795
Safety and clinical activity with an anti-PD-1 antibody JS001 in advanced melanoma or urologic cancer patients. Bixia Tang, Xieqiao Yan, +20 authors, Jun Guo. less J Hematol Oncol, 2019 Jan 16; 12(1). PMID: 30642373 Free PMC article. Highly Cited.
Engineering Nanoparticles for Targeted Remodeling of the Tumor Microenvironment to Improve Cancer Immunotherapy. Shan Gao, Dongjuan Yang, +6 authors, Kai Shi. less Theranostics, 2019 Jan 22; 9(1). PMID: 30662558 Free PMC article. Highly Cited. Review.
WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer. Lorenzo Castagnoli, Valeria Cancila, +13 authors, Serenella M Pupa. less Oncogene, 2019 Feb 02; 38(21). PMID: 30705400 Free PMC article. Highly Cited.
Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti-PD-1 in melanoma. Laurene S Cheung, Juan Fu, +10 authors, William R Bishai. less Proc Natl Acad Sci U S A, 2019 Feb 06; 116(8). PMID: 30718426 Free PMC article.
Divergent SATB1 expression across human life span and tissue compartments. Simone Nüssing, Hui-Fern Koay, +12 authors, Katherine Kedzierska. less Immunol Cell Biol, 2019 Feb 26; 97(5). PMID: 30803026 Free PMC article.
The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy. Gui-Zhen Wang, Li Zhang, +11 authors, Guang-Biao Zhou. less Nat Commun, 2019 Mar 10; 10(1). PMID: 30850589 Free PMC article. Highly Cited.
An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE). Derek L Clouthier, Scott C Lien, +30 authors, Lillian L Siu. less J Immunother Cancer, 2019 Mar 15; 7(1). PMID: 30867072 Free PMC article.
Mutually assured destruction: the cold war between viruses and natural killer cells. Ayad Ali, Ivayla E Gyurova, Stephen N Waggoner. Curr Opin Virol, 2019 Mar 17; 34. PMID: 30877885 Free PMC article. Review.
Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy. Karin M Knudson, Kristin C Hicks, +2 authors, Sarah Alter, Jeffrey Schlom, Sofia R Gameiro. less J Immunother Cancer, 2019 Mar 23; 7(1). PMID: 30898149 Free PMC article.
Dynamic host immune response in virus-associated cancers. Song Cao, Kristine M Wylie, +13 authors, Li Ding. less Commun Biol, 2019 Mar 27; 2. PMID: 30911684 Free PMC article.
Bispecific CD3-HAC carried by E1A-engineered mesenchymal stromal cells against metastatic breast cancer by blocking PD-L1 and activating T cells. Yuanyuan Yang, Xiaolong Zhang, +11 authors, Dongsheng Xiong. less J Hematol Oncol, 2019 Apr 27; 12(1). PMID: 31023384 Free PMC article.
Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside. Justin Korfhage, David B Lombard. Mol Cancer Res, 2019 Apr 27; 17(7). PMID: 31023785 Free PMC article. Review.
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Weimin Wang, Michael Green, +27 authors, Weiping Zou. less Nature, 2019 May 03; 569(7755). PMID: 31043744 Free PMC article. Highly Cited.
Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy. Qiang Zhang, Michael D Green, +14 authors, Meredith A Morgan. less Cancer Res, 2019 May 19; 79(15). PMID: 31101760 Free PMC article. Highly Cited.
Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity. Xinyue Qi, Fanlin Li, +4 authors, Xuanming Yang. less Nat Commun, 2019 May 21; 10(1). PMID: 31105267 Free PMC article.
The local immune landscape determines tumor PD-L1 heterogeneity and sensitivity to therapy. Yuan Wei, Qiyi Zhao, +9 authors, Dong-Ming Kuang. less J Clin Invest, 2019 May 22; 129(8). PMID: 31112529 Free PMC article. Highly Cited.
A novel model of controlling PD-L1 expression in ALK+ anaplastic large cell lymphoma revealed by CRISPR screening. Jing-Ping Zhang, Zhihui Song, +10 authors, Yibin Yang. less Blood, 2019 Jun 04; 134(2). PMID: 31151983 Free PMC article.
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. Li-Chuan Chan, Chia-Wei Li, +26 authors, Mien-Chie Hung. less J Clin Invest, 2019 Jul 16; 129(8). PMID: 31305264 Free PMC article. Highly Cited.
A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control. Zhichen Sun, Zhenhua Ren, +12 authors, Hua Peng. less Nat Commun, 2019 Aug 30; 10(1). PMID: 31462678 Free PMC article.
CD137 ligand feedback upregulates PD-L1 expression on lung cancer via T cell production of IFN-γ. Helin Wang, Zhuohong Yan, +7 authors, Shucai Zhang. less Thorac Cancer, 2019 Oct 19; 10(12). PMID: 31625289 Free PMC article.
Small molecules as theranostic agents in cancer immunology. Jindian Li, Juno Van Valkenburgh, +3 authors, Kai Chen. less Theranostics, 2019 Nov 07; 9(25). PMID: 31695804 Free PMC article. Review.
A Single-Step Chemoenzymatic Reaction for the Construction of Antibody-Cell Conjugates. Jie Li, Mingkuan Chen, +7 authors, Peng Wu. less ACS Cent Sci, 2019 Jan 17; 4(12). PMID: 30648147 Free PMC article.
Tumor-Infiltrating Lymphocytes in the Checkpoint Inhibitor Era. Gerald P Linette, Beatriz M Carreno. Curr Hematol Malig Rep, 2019 Jun 13; 14(4). PMID: 31187421 Free PMC article. Review.
Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy. Jung-Ho Kim, Beom Seok Kim, Sang-Kyou Lee. Immune Netw, 2020 Mar 12; 20(1). PMID: 32158592 Free PMC article. Review.
Comprehensive molecular profiling of the B7 family in gastrointestinal cancer. Qijie Zhao, Fuyan Hu, +10 authors, Jing Shen. less Cell Prolif, 2018 Jul 13; 51(5). PMID: 29999557 Free PMC article.
Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer. Prachya Kongtawelert, Benjawan Wudtiwai, +2 authors, Thanyaluck Phitak. less Molecules, 2020 Jan 16; 25(2). PMID: 31936263 Free PMC article.
Resistance Mechanisms and Barriers to Successful Immunotherapy for Treating Glioblastoma. Jason Adhikaree, Julia Moreno-Vicente, +2 authors, Poulam M Patel. less Cells, 2020 Jan 25; 9(2). PMID: 31973059 Free PMC article. Review.
Immune-Related Adverse Events in the Setting of PD-1/L1 Inhibitor Combination Therapy. Leyre Zubiri, Ian M Allen, +16 authors, Kerry L Reynolds. less Oncologist, 2020 Mar 13; 25(3). PMID: 32162817 Free PMC article.
BRD4 Inhibition by AZD5153 Promotes Antitumor Immunity via Depolarizing M2 Macrophages. Xi Li, Yu Fu, +10 authors, Gang Chen. less Front Immunol, 2020 Mar 19; 11. PMID: 32184777 Free PMC article.
Advances and challenges in immunotherapy of small cell lung cancer. Hanfei Guo, Lingyu Li, Jiuwei Cui. Chin J Cancer Res, 2020 Mar 21; 32(1). PMID: 32194311 Free PMC article.
C-Myc regulates PD-L1 expression in esophageal squamous cell carcinoma. Ming-Qiang Liang, Feng-Qiang Yu, Chun Chen. Am J Transl Res, 2020 Mar 21; 12(2). PMID: 32194890 Free PMC article.
T cell recruitment triggered by optimal dose platinum compounds contributes to the therapeutic efficacy of sequential PD-1 blockade in a mouse model of colon cancer. Deqiang Fu, Jichun Wu, +4 authors, Qiuyu Zhang. less Am J Cancer Res, 2020 Mar 21; 10(2). PMID: 32195021 Free PMC article.
Safety and immunogenicity of a potential checkpoint blockade vaccine for canine melanoma. Raj K Kurupati, Xiangyang Zhou, +2 authors, Zhiquan Xiang, Lorraine H Keller, Hildegund C J Ertl. less Cancer Immunol Immunother, 2018 Jul 28; 67(10). PMID: 30051333 Free PMC article.
Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect. Yang Du, Yinhua Jin, +3 authors, Wei Sun, Junjie Fang, Jianjun Zheng, Jie Tian. less Eur Radiol, 2018 Dec 07; 29(8). PMID: 30506221 Free PMC article. Review.
Nanotherapeutics for Immuno-Oncology: A Crossroad for New Paradigms. Wantong Song, Manisit Das, Xuesi Chen. Trends Cancer, 2020 Mar 27; 6(4). PMID: 32209444 Free PMC article. Review.
Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy. Ryusuke Hatae, Kenji Chamoto, +13 authors, Tasuku Honjo. less JCI Insight, 2019 Dec 20; 5(2). PMID: 31855576 Free PMC article.
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety. Yan Ge, Haiyan Wang, +10 authors, David L Bartlett. less J Immunother Cancer, 2020 Mar 27; 8(1). PMID: 32209602 Free PMC article.
Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy. Alok Kumar, Kenji Chamoto, Partha S Chowdhury, Tasuku Honjo. Elife, 2020 Mar 04; 9. PMID: 32122466 Free PMC article.
Empowering therapeutic antibodies with IFN-α for cancer immunotherapy. Jun Guo, Yu Xiao, +10 authors, Tzu-Hsuan Huang. less PLoS One, 2019 Aug 09; 14(8). PMID: 31393905 Free PMC article.
Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy. Xiaodong Wang, Xiaohui Yang, +21 authors, Shan Gao. less Proc Natl Acad Sci U S A, 2020 Mar 13; 117(12). PMID: 32161124 Free PMC article.
Complementing the Cancer-Immunity Cycle. Ruben Pio, Daniel Ajona, +2 authors, John D Lambris. less Front Immunol, 2019 Apr 30; 10. PMID: 31031765 Free PMC article. Highly Cited. Review.
Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy. Hongwei Chen, Xin Luan, +7 authors, Duxin Sun. less Nanomedicine (Lond), 2019 Dec 24; 15(1). PMID: 31868112 Free PMC article.
Prognostic significance of PD-L1 expression on cell-surface vimentin-positive circulating tumor cells in gastric cancer patients. Mengyuan Liu, Ruoyu Wang, +16 authors, Mingjun Sun. less Mol Oncol, 2020 Jan 26; 14(4). PMID: 31981446 Free PMC article.
A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients. Jing Yang, Meilian Dong, +9 authors, Yonggang Shi. less Cancer Cell Int, 2020 Apr 08; 20. PMID: 32256205 Free PMC article.
The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells. Dong Young Kang, Nipin Sp, +7 authors, Young Mok Yang. less Cancers (Basel), 2020 Mar 25; 12(3). PMID: 32204508 Free PMC article.
Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes. Yonghyo Kim, Jeovanis Gil, +17 authors, György Marko-Varga. less Cancers (Basel), 2020 Mar 28; 12(3). PMID: 32213878 Free PMC article.
IL-36β Promotes CD8+ T Cell Activation and Antitumor Immune Responses by Activating mTORC1. Xin Zhao, Xiaojuan Chen, +13 authors, Xuefeng Wang. less Front Immunol, 2019 Aug 27; 10. PMID: 31447838 Free PMC article.
New Approaches on Cancer Immunotherapy. Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, Mien-Chie Hung. Cold Spring Harb Perspect Med, 2019 Oct 17; 10(8). PMID: 31615865 Free PMC article. Review.
Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9-genome editing promotes antitumor immunity and suppresses ovarian cancer progression. Tamaki Yahata, Mika Mizoguchi, +13 authors, Kazuhiko Ino. less Cancer Sci, 2019 Feb 01; 110(4). PMID: 30702189 Free PMC article.
Hypoxia-inducible factor-1α and nuclear factor-κB play important roles in regulating programmed cell death ligand 1 expression by epidermal growth factor receptor mutants in non-small-cell lung cancer cells. Rong Guo, Yong Li, +5 authors, Jie Wang. less Cancer Sci, 2019 Mar 08; 110(5). PMID: 30844110 Free PMC article.
Rational application of the first-line chemotherapy and immune checkpoint inhibitors in advanced nonsmall cell lung cancer: A meta-analysis. Rui Cao, Jie-Tao Ma, +6 authors, Cheng-Bo Han. less Cancer Med, 2019 Jul 13; 8(11). PMID: 31297962 Free PMC article.
VISTA: Coming of age as a multi-lineage immune checkpoint. M A ElTanbouly, E Schaafsma, R J Noelle, J L Lines. Clin Exp Immunol, 2020 Jan 14; 200(2). PMID: 31930484 Free PMC article. Review.
Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors. Rachel Grosser, Leonid Cherkassky, Navin Chintala, Prasad S Adusumilli. Cancer Cell, 2019 Nov 13; 36(5). PMID: 31715131 Free PMC article. Review.
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Jun Wang, Jingwei Sun, +16 authors, Lieping Chen. less Nat Med, 2019 Mar 06; 25(4). PMID: 30833750 Free PMC article. Highly Cited.
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer. Abel H Y Tan, WenJuan Tu, +5 authors, Sudha Rao. less Front Immunol, 2019 Jun 30; 10. PMID: 31249575 Free PMC article.
The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies. Jun Gong, Alexander Chehrazi-Raffle, +3 authors, Ravi Salgia. less Clin Transl Med, 2019 Mar 20; 8(1). PMID: 30887236 Free PMC article. Highly Cited. Review.
CAR T cell therapy: newer approaches to counter resistance and cost. Rajesh Kumar Yadav, Asgar Ali, +6 authors, Sadhana Sharma. less Heliyon, 2020 Apr 24; 6(4). PMID: 32322738 Free PMC article. Review.
Histone Deacetylase Inhibition Sensitizes PD1 Blockade-Resistant B-cell Lymphomas. Xiaoguang Wang, Brittany C Waschke, +5 authors, Jing H Wang. less Cancer Immunol Res, 2019 Jun 27; 7(8). PMID: 31235619 Free PMC article.
Effects of anti-PD-1 immunotherapy on tumor regression: insights from a patient-derived xenograft model. Asunción Martín-Ruiz, Carmen Fiuza-Luces, +7 authors, Mariano Provencio. less Sci Rep, 2020 Apr 29; 10(1). PMID: 32341383 Free PMC article.
Comprehensive Analysis of the Expression and Prognosis for TDO2 in Breast Cancer. Qiang Liu, Jie Zhai, +4 authors, Jing Wang. less Mol Ther Oncolytics, 2020 Apr 30; 17. PMID: 32346606 Free PMC article.
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy. Jing Li, Weichao Wang, +22 authors, Weiping Zou. less J Clin Invest, 2020 Feb 07; 130(5). PMID: 32027624 Free PMC article.
Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer. Fan Luo, Min Luo, +5 authors, Li-Wu Fu. less J Immunother Cancer, 2019 Sep 13; 7(1). PMID: 31511071 Free PMC article.
Lesion-Level Response Dynamics to Programmed Cell Death Protein (PD-1) Blockade. Juan C Osorio, Kathryn C Arbour, +14 authors, Matthew D Hellmann. less J Clin Oncol, 2019 Nov 02; 37(36). PMID: 31675272 Free PMC article.
Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation. Xinfang Yu, Wei Li, +9 authors, Yong Li. less J Hematol Oncol, 2020 May 03; 13(1). PMID: 32357935 Free PMC article.
Prognostic and predictive value of an immune infiltration signature in diffuse lower-grade gliomas. Lai-Rong Song, Jian-Cong Weng, +7 authors, Jun-Ting Zhang. less JCI Insight, 2020 Apr 02; 5(8). PMID: 32229719 Free PMC article.
Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3-CD8+ T cells. Sisi Deng, Zhichen Sun, +8 authors, Hua Peng. less JCI Insight, 2020 Apr 10; 5(7). PMID: 32271164 Free PMC article.
Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist. Karin M Knudson, Kristin C Hicks, +2 authors, Yohei Ozawa, Jeffrey Schlom, Sofia R Gameiro. less J Immunother Cancer, 2020 Apr 19; 8(1). PMID: 32303618 Free PMC article.
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Reactive Oxygen Species in the Tumor Microenvironment: An Overview. Frank Weinberg, Nithya Ramnath, Deepak Nagrath. Cancers (Basel), 2019 Aug 21; 11(8). PMID: 31426364 Free PMC article. Highly Cited. Review.
Anti PD-1 monoclonal antibody induced autoimmune diabetes mellitus: a case report and brief review. Wei Li, Hao Wang, +6 authors, Caicun Zhou. less Transl Lung Cancer Res, 2020 May 19; 9(2). PMID: 32420079 Free PMC article.
Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti-PD-L1 immunotherapy. Zhaoting Li, Yixin Wang, +3 authors, Minjie Sun. less Sci Adv, 2020 May 23; 6(20). PMID: 32440550 Free PMC article.
Immunotherapy: Checkpoint Inhibitors in Lynch-Associated Gynecologic Cancers. J Stuart Ferriss, M Yvette Williams-Brown. Curr Treat Options Oncol, 2019 Aug 25; 20(10). PMID: 31444655 Review.
Normalization Cancer Immunotherapy for Melanoma. Matthew D Vesely, Lieping Chen. J Invest Dermatol, 2020 Feb 25; 140(6). PMID: 32092349 Free PMC article.
Blocking Triggering Receptor Expressed on Myeloid Cells-1-Positive Tumor-Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti-Programmed Cell Death Ligand 1 Resistance in Liver Cancer. Qinchuan Wu, Wuhua Zhou, +10 authors, Shusen Zheng. less Hepatology, 2019 Feb 28; 70(1). PMID: 30810243 Free PMC article. Highly Cited.
Endoplasmic Reticulum Stress Causes Liver Cancer Cells to Release Exosomal miR-23a-3p and Up-regulate Programmed Death Ligand 1 Expression in Macrophages. Jiatao Liu, Lulu Fan, +12 authors, Guoping Sun. less Hepatology, 2019 Mar 12; 70(1). PMID: 30854665 Free PMC article. Highly Cited.
Extracellular Vesicles in Renal Cell Carcinoma: Multifaceted Roles and Potential Applications Identified by Experimental and Computational Methods. Zhiyuan Qin, Qingwen Xu, +2 authors, Haihong Hu, Lushan Yu, Su Zeng. less Front Oncol, 2020 May 28; 10. PMID: 32457844 Free PMC article. Review.
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Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway. Chao Liu, Zhaoying Yao, +14 authors, Qianming Du. less Cell Death Differ, 2019 Dec 06; 27(6). PMID: 31802034 Free PMC article.
Diagnostic value of 18F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8+tumour-infiltrating lymphocytes in oral squamous cell carcinoma. Maria Togo, Takehiko Yokobori, +8 authors, Tetsunari Oyama. less Br J Cancer, 2020 Apr 03; 122(11). PMID: 32238919 Free PMC article.
Prognostic value of programmed cell death ligand-1 expression in ovarian cancer: an updated meta-analysis. Jinlan Piao, Hyun Ji Lim, Maria Lee. Obstet Gynecol Sci, 2020 Jun 04; 63(3). PMID: 32489980 Free PMC article.
Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker-based immunotherapy. Feihu Wang, Dongqing Xu, +11 authors, Honggang Cui. less Sci Adv, 2020 Jun 04; 6(18). PMID: 32490201 Free PMC article.
A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target. Zachary T Freeman, Thomas R Nirschl, +17 authors, Charles G Drake. less J Clin Invest, 2020 Feb 06; 130(3). PMID: 32015231 Free PMC article.
Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies. Rong Fu, Yi Li, +9 authors, Zhao-Qiu Wu. less J Clin Invest, 2020 Feb 11; 130(3). PMID: 32039918 Free PMC article.
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PD-L1 produced by HaCaT cells under polyinosinic-polycytidylic acid stimulation inhibits melanin production by B16F10 cells. Minhwa Park, So-Youn Woo, +2 authors, Kyung-Ah Cho, Min-Sun Cho, Kyung Ho Lee. less PLoS One, 2020 May 22; 15(5). PMID: 32437407 Free PMC article.
Tumor immune microenvironment in head and neck cancers. Samantha M Y Chen, Alexandra L Krinsky, +3 authors, Jing H Wang. less Mol Carcinog, 2020 Feb 06; 59(7). PMID: 32017286 Free PMC article. Review.
Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity. Daniel S Leventhal, Anna Sokolovska, +13 authors, Jose M Lora. less Nat Commun, 2020 Jun 03; 11(1). PMID: 32483165 Free PMC article.
Supramolecular Self-Assembled Nanostructures for Cancer Immunotherapy. Zichao Huang, Wantong Song, Xuesi Chen. Front Chem, 2020 Jun 13; 8. PMID: 32528926 Free PMC article. Review.
Expanding the Spectrum of Adenoviral Vectors for Cancer Therapy. Jian Gao, Wenli Zhang, Anja Ehrhardt. Cancers (Basel), 2020 May 07; 12(5). PMID: 32370135 Free PMC article. Review.
DNA hypomethylation promotes transposable element expression and activation of immune signaling in renal cell cancer. Aguirre A de Cubas, William Dunker, +8 authors, W Kimryn Rathmell. less JCI Insight, 2020 Jun 05; 5(11). PMID: 32493845 Free PMC article.
NF-κB and Its Role in Checkpoint Control. Annika C Betzler, Marie-Nicole Theodoraki, +4 authors, Cornelia Brunner. less Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486375 Free PMC article. Review.
Mouse Tumor Models for Advanced Cancer Immunotherapy. Daria S Chulpanova, Kristina V Kitaeva, +2 authors, Catrin S Rutland, Albert A Rizvanov, Valeriya V Solovyeva. less Int J Mol Sci, 2020 Jun 13; 21(11). PMID: 32526987 Free PMC article. Review.
The interaction between ferroptosis and lipid metabolism in cancer. Dingshan Li, Yongsheng Li. Signal Transduct Target Ther, 2020 Jul 02; 5(1). PMID: 32606298 Free PMC article. Review.
The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis. Ying-Nai Wang, Heng-Huan Lee, +2 authors, Jennifer L Hsu, Dihua Yu, Mien-Chie Hung. less J Biomed Sci, 2020 Jul 06; 27(1). PMID: 32620165 Free PMC article. Review.
Mechanistic insight of predictive biomarkers for antitumor PD‑1/PD‑L1 blockade: A paradigm shift towards immunome evaluation (Review). Wenjie You, Bin Shang, +3 authors, Jian Sun, Xueqing Liu, Lili Su, Shujuan Jiang. less Oncol Rep, 2020 Jul 07; 44(2). PMID: 32627031 Free PMC article. Review.
PD-L1 Expression Affects Neoantigen Presentation. Masahiro Okada, Kanako Shimizu, +6 authors, Shin-Ichiro Fujii. less iScience, 2020 Jul 08; 23(6). PMID: 32629606 Free PMC article.
Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications. Lidia Yshii, Chloé Bost, Roland Liblau. Front Immunol, 2020 Jul 14; 11. PMID: 32655545 Free PMC article. Review.
Chemoradioimmunotherapy of inoperable stage III non-small cell lung cancer: immunological rationale and current clinical trials establishing a novel multimodal strategy. Lukas Käsmann, Chukwuka Eze, +6 authors, Farkhad Manapov. less Radiat Oncol, 2020 Jul 11; 15(1). PMID: 32646443 Free PMC article. Review.
Novel Immunotherapeutic Approaches in Head and Neck Cancer. M E Heft Neal, C T Haring, +3 authors, J E Mann, J C Brenner, M E Spector, P L Swiecicki. less J Cancer Metastasis Treat, 2019 Jan 01; 5. PMID: 32661502 Free PMC article.
Producing Soluble Human Programmed Cell Death Protein-1: A Natural Supporter for CD4+T Cell Cytotoxicity and Tumor Cells Apoptosis. Samane Mohammadzadeh, Hossein Khanahmad, +4 authors, Alireza Andalib. less Iran J Biotechnol, 2020 Jul 17; 17(4). PMID: 32671122 Free PMC article.
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells. Yu Wang, Qingguo Sun, +5 authors, Xiangguo Liu. less Cell Commun Signal, 2020 Jul 16; 18(1). PMID: 32665011 Free PMC article.
Integrating the Tumor Microenvironment into Cancer Therapy. Sabina Sanegre, Federico Lucantoni, +3 authors, Tomás Álvaro Naranjo. less Cancers (Basel), 2020 Jul 01; 12(6). PMID: 32599891 Free PMC article. Review.
Converting Immune Cold into Hot by Biosynthetic Functional Vesicles to Boost Systematic Antitumor Immunity. Ming Wu, Dongye Zheng, +10 authors, Xiaolong Liu. less iScience, 2020 Jul 20; 23(7). PMID: 32683314 Free PMC article.
Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction. Tingting Wang, J N Rashida Gnanaprakasam, +20 authors, Ruoning Wang. less Nat Metab, 2020 Jul 23; 2(7). PMID: 32694789 Free PMC article.
Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer. Noffar Bar, Federica Costa, +19 authors, Madhav V Dhodapkar. less JCI Insight, 2020 May 20; 5(12). PMID: 32427579 Free PMC article.
CD73 acts as a prognostic biomarker and promotes progression and immune escape in pancreatic cancer. Qiangda Chen, Ning Pu, +4 authors, Wenchuan Wu. less J Cell Mol Med, 2020 Jul 10; 24(15). PMID: 32643277 Free PMC article.
Tumor-Associated CD163+ M2 Macrophage Infiltration is Highly Associated with PD-L1 Expression in Cervical Cancer. Fan Guo, Yang-Chun Feng, +7 authors, Xiu-Min Ma. less Cancer Manag Res, 2020 Aug 09; 12. PMID: 32765086 Free PMC article.
Nanomedicine and Onco-Immunotherapy: From the Bench to Bedside to Biomarkers. Vanessa Acebes-Fernández, Alicia Landeria-Viñuela, +5 authors, Manuel Fuentes. less Nanomaterials (Basel), 2020 Jul 03; 10(7). PMID: 32610601 Free PMC article. Review.
Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana. Somanath Kallolimath, Thomas Hackl, +6 authors, Herta Steinkellner. less Front Bioeng Biotechnol, 2020 Aug 15; 8. PMID: 32793574 Free PMC article.
Current progress and prospect of immune checkpoint inhibitors in hepatocellular carcinoma. Zhu Zeng, Biao Yang, Zheng-Yin Liao. Oncol Lett, 2020 Aug 18; 20(4). PMID: 32802167 Free PMC article. Review.
[18F]FDG PET immunotherapy radiomics signature (iRADIOMICS) predicts response of non-small-cell lung cancer patients treated with pembrolizumab. Damijan Valentinuzzi, Martina Vrankar, +9 authors, Robert Jeraj. less Radiol Oncol, 2020 Jul 30; 54(3). PMID: 32726293 Free PMC article.
Subtype and grade-dependent spatial heterogeneity of T-cell infiltration in pediatric glioma. M Hope Robinson, Juan Vasquez, +4 authors, Kavita Dhodapkar. less J Immunother Cancer, 2020 Aug 14; 8(2). PMID: 32788236 Free PMC article.
Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma. Jianzhen Lin, Xu Yang, +20 authors, Haitao Zhao. less Hepatobiliary Surg Nutr, 2020 Aug 25; 9(4). PMID: 32832493 Free PMC article.
Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins. Emelie Foord, Charlotte Klynning, +13 authors, Michael Uhlin. less J Immunol Res, 2020 Aug 25; 2020. PMID: 32832572 Free PMC article.
Ultrathin metal-organic layer-mediated radiotherapy-radiodynamic therapy enhances immunotherapy of metastatic cancers. Kaiyuan Ni, Guangxu Lan, +5 authors, Wenbin Lin. less Matter, 2020 Aug 25; 1(5). PMID: 32832885 Free PMC article.
Progress in Neoantigen Targeted Cancer Immunotherapies. Xue-Jiao Han, Xue-Lei Ma, +3 authors, Li Yang, Yu-Quan Wei, Yong Peng, Xia-Wei Wei. less Front Cell Dev Biol, 2020 Aug 28; 8. PMID: 32850843 Free PMC article. Review.
Resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms, predictive factors, and future perspectives. Jin-Yu Sun, Dengke Zhang, +4 authors, Jiansong Ji. less Biomark Res, 2020 Aug 31; 8. PMID: 32864132 Free PMC article. Review.
Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer. Min Luo, Fang Wang, +5 authors, Liwu Fu. less Signal Transduct Target Ther, 2020 Aug 29; 5(1). PMID: 32855386 Free PMC article.
Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients. Seung-Myoung Son, Chang Gok Woo, +12 authors, Hye Sook Han. less Sci Rep, 2020 Sep 02; 10(1). PMID: 32868848 Free PMC article.
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance. Vivek Verma, Rajeev K Shrimali, +25 authors, Samir N Khleif. less Nat Immunol, 2019 Jul 31; 20(9). PMID: 31358999 Free PMC article. Highly Cited.
The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma. Joji Nagasaki, Yosuke Togashi, +10 authors, Hiroyoshi Nishikawa. less Blood Adv, 2020 Sep 02; 4(17). PMID: 32870971 Free PMC article.
The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. Cheng-Wei Chou, Ri-Yao Yang, +7 authors, Mien-Chie Hung. less Am J Cancer Res, 2020 Sep 10; 10(8). PMID: 32905506 Free PMC article.
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Yang Gao, Naoe Taira Nihira, +24 authors, Wenyi Wei. less Nat Cell Biol, 2020 Aug 26; 22(9). PMID: 32839551 Free PMC article.
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Yingjie Bian, Wei Li, +26 authors, Weiping Zou. less Nature, 2020 Sep 04; 585(7824). PMID: 32879489 Free PMC article.
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner. Qian-Feng Zhang, Jia Li, +7 authors, Bi-Liang Chen. less Theranostics, 2020 Sep 16; 10(23). PMID: 32929370 Free PMC article.
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity. Ilgen Mender, Anli Zhang, +8 authors, Yang-Xin Fu. less Cancer Cell, 2020 Jul 04; 38(3). PMID: 32619407 Free PMC article.
Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis. Baihui Li, Bailu Zhang, +6 authors, Lili Yang. less Oncoimmunology, 2020 Sep 18; 9(1). PMID: 32939323 Free PMC article.
Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen-Deuterium Exchange, Cross-linking, and Molecular Docking. Mengru Mira Zhang, Richard Y-C Huang, +4 authors, Michael L Gross. less Anal Chem, 2020 May 23; 92(13). PMID: 32441507 Free PMC article.
Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis. Wantong Song, Karthik Tiruthani, +7 authors, Leaf Huang. less Adv Mater, 2018 Nov 06; 30(52). PMID: 30387230 Free PMC article.
Association of B7-H4, PD-L1, and tumor infiltrating lymphocytes with outcomes in breast cancer. Mehmet Altan, Kelley M Kidwell, +7 authors, David L Rimm. less NPJ Breast Cancer, 2018 Dec 20; 4. PMID: 30564631 Free PMC article.
B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells. Weiwei Yu, Ling Chen, +2 authors, Sizheng Guo, Liqun Luo, Lieping Chen. less Oncoimmunology, 2018 Dec 24; 7(11). PMID: 30574431 Free PMC article.
Treatment of advanced hepatocellular carcinoma: immunotherapy from checkpoint blockade to potential of cellular treatment. Elaine Hon-Lam Siu, Anthony Wing-Hung Chan, +3 authors, Siu Tim Cheung. less Transl Gastroenterol Hepatol, 2019 Jan 04; 3. PMID: 30603725 Free PMC article. Review.
Analysis of PD-1 related immune transcriptional profile in different cancer types. Jun Shang, Qian Song, +5 authors, Sihua Wang. less Cancer Cell Int, 2019 Jan 05; 18. PMID: 30607140 Free PMC article.
Identification of hub genes and outcome in colon cancer based on bioinformatics analysis. Wanli Yang, Jiaojiao Ma, +10 authors, Daiming Fan. less Cancer Manag Res, 2019 Jan 16; 11. PMID: 30643458 Free PMC article.
Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors. Renata Boldrini, Maria Debora De Pasquale, +11 authors, Doriana Fruci. less Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713803 Free PMC article.
PDL-1 Antibody Drug Conjugate for Selective Chemo-Guided Immune Modulation of Cancer. Samaresh Sau, Alex Petrovici, +2 authors, Hashem O Alsaab, Ketki Bhise, Arun K Iyer. less Cancers (Basel), 2019 Feb 20; 11(2). PMID: 30781490 Free PMC article.
A Feedback Loop Formed by ATG7/Autophagy, FOXO3a/miR-145 and PD-L1 Regulates Stem-Like Properties and Invasion in Human Bladder Cancer. Junlan Zhu, Yang Li, +6 authors, Chuanshu Huang. less Cancers (Basel), 2019 Mar 16; 11(3). PMID: 30871066 Free PMC article.
The Prognostic and Clinicopathological Roles of PD-L1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis. Yan Li, Meizhi He, +5 authors, Lang Xie. less Front Pharmacol, 2019 Mar 16; 10. PMID: 30873025 Free PMC article. Systematic Review.
PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications. Pramod Darvin, Varun Sasidharan Nair, Eyad Elkord. J Oncol, 2019 Mar 28; 2019. PMID: 30915120 Free PMC article.
A Changing of the Guard: Immune Checkpoint Inhibitors With and Without Chemotherapy as First Line Treatment for Metastatic Non-small Cell Lung Cancer. Jose M Pacheco, D Ross Camidge, Robert C Doebele, Erin Schenk. Front Oncol, 2019 Apr 16; 9. PMID: 30984621 Free PMC article. Highly Cited. Review.
Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy. Daniele Lecis, Sabina Sangaletti, Mario P Colombo, Claudia Chiodoni. Cancers (Basel), 2019 May 08; 11(5). PMID: 31060225 Free PMC article. Review.
Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy. Esteban Cruz, Veysel Kayser. Biologics, 2019 May 24; 13. PMID: 31118560 Free PMC article. Highly Cited. Review.
MicroRNAs aid the assessment of programmed death ligand 1 expression in patients with non-small cell lung cancer. Anna Grenda, Marcin Nicoś, +8 authors, Janusz Milanowski. less Oncol Lett, 2019 Jun 13; 17(6). PMID: 31186735 Free PMC article.
Circulating Lymphocytes, PD-L1 Expression on Tumor-infiltrating Lymphocytes, and Survival of Colorectal Cancer Patients with Different Mismatch Repair Gene Status. Pengfei Kong, Jing Wang, +7 authors, Liangping Xia. less J Cancer, 2019 Jun 18; 10(7). PMID: 31205530 Free PMC article.
Regulation of T cell antitumor immune response by tumor induced metabolic stress. Fanny Chalmin, Mélanie Bruchard, Frederique Vegran, Francois Ghiringhelli. Cell Stress, 2019 Jun 22; 3(1). PMID: 31225495 Free PMC article. Review.
Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent. Katrijn Broos, Quentin Lecocq, +9 authors, Karine Breckpot. less Cancers (Basel), 2019 Jun 27; 11(6). PMID: 31234464 Free PMC article.
Anti-CD40 mAb enhanced efficacy of anti-PD1 against osteosarcoma. Jingzhe Zhang, Ye Li, +2 authors, Shoujun Yang, Lening Zhang, Wenjun Wang. less J Bone Oncol, 2019 Jul 12; 17. PMID: 31293882 Free PMC article.
Integrated assessment of PD-L1 expression and molecular classification facilitates therapy selection and prognosis prediction in gastric cancer. Yeqi Sun, Wenwei Yu, +6 authors, Lifeng Wang. less Cancer Manag Res, 2019 Aug 03; 11. PMID: 31372044 Free PMC article.
Differential expression of efferocytosis and phagocytosis associated genes in tumor associated macrophages exposed to African American patient derived prostate cancer microenvironment. Hirendra Banerjee, Christopher Krauss, +8 authors, Santosh Mandal. less J Solid Tumors, 2019 Aug 27; 9(2). PMID: 31447959 Free PMC article.
LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells. Xinke Wang, Zhixian Lan, +11 authors, Side Liu. less Cancer Cell Int, 2019 Sep 14; 19. PMID: 31516391 Free PMC article.
Immunosuppressive checkpoint Siglec-15: a vital new piece of the cancer immunotherapy jigsaw puzzle. Xiubao Ren. Cancer Biol Med, 2019 Sep 14; 16(2). PMID: 31516742 Free PMC article.
The clinicopathological and prognostic significance of PD-L1 expression assessed by immunohistochemistry in lung cancer: a meta-analysis of 50 studies with 11,383 patients. Huijuan Li, Yangyang Xu, +12 authors, written on behalf of AME Lung Cancer Collaborative Group. less Transl Lung Cancer Res, 2019 Sep 27; 8(4). PMID: 31555517 Free PMC article.
Nanoparticles Presenting Potent TLR7/8 Agonists Enhance Anti-PD-L1 Immunotherapy in Cancer Treatment. Anton A A Smith, Emily C Gale, +4 authors, Eric A Appel. less Biomacromolecules, 2020 Aug 21; 21(9). PMID: 32816460 Free PMC article.
A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis. Lin Qin, Jun Cao, +8 authors, Nicholas A Peppas. less Sci Adv, 2020 Sep 13; 6(36). PMID: 32917616 Free PMC article.
HSPA12B Secreted by Tumor-Associated Endothelial Cells Might Induce M2 Polarization of Macrophages via Activating PI3K/Akt/mTOR Signaling. Jingjie Zhou, Aiping Zhang, Liang Fan. Onco Targets Ther, 2020 Sep 29; 13. PMID: 32982299 Free PMC article.
Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer. Junji Akagi, Hideo Baba. Oncol Lett, 2020 Oct 01; 20(5). PMID: 32994821 Free PMC article.
Hybrid Fc-fused interleukin-7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy. Ji-Hae Kim, Young-Min Kim, +11 authors, Seung-Woo Lee. less Clin Transl Immunology, 2020 Oct 01; 9(9). PMID: 32994996 Free PMC article.
An implantable blood clot-based immune niche for enhanced cancer vaccination. Qin Fan, Qingle Ma, +7 authors, Chao Wang. less Sci Adv, 2020 Sep 27; 6(39). PMID: 32978163 Free PMC article.
PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade. Qi Peng, Xiangyan Qiu, +8 authors, Haidong Tang. less Nat Commun, 2020 Sep 26; 11(1). PMID: 32973173 Free PMC article.
Why the Outcome of Anti-Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers. Jing H Wang. Bioessays, 2020 Aug 09; 42(10). PMID: 32767371 Free PMC article.
PD-L1 and prognosis in patients with malignant pleural mesothelioma: a meta-analysis and bioinformatics study. Liu Jin, Weiling Gu, +3 authors, Xueqin Li, Liang Xie, Linhong Wang, Zhongwen Chen. less Ther Adv Med Oncol, 2020 Oct 17; 12. PMID: 33062064 Free PMC article.
Prognostic and Immunological Value of Angiotensin-Converting Enzyme 2 in Pan-Cancer. Huan Feng, Xian Wei, +6 authors, Tao Wang. less Front Mol Biosci, 2020 Oct 23; 7. PMID: 33088807 Free PMC article.
Tumor Immune Microenvironments (TIMEs): Responsive Nanoplatforms for Antitumor Immunotherapy. Xueqing Sui, Teng Jin, +7 authors, Hua Zhang. less Front Chem, 2020 Oct 24; 8. PMID: 33094098 Free PMC article. Review.
Estrogen Receptor Downregulates Expression of PD-1/PD-L1 and Infiltration of CD8+ T Cells by Inhibiting IL-17 Signaling Transduction in Breast Cancer. Chong Shuai, Xinmei Yang, Hongming Pan, Weidong Han. Front Oncol, 2020 Oct 27; 10. PMID: 33102239 Free PMC article.
Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions. Guoming Zeng, Libo Jin, +9 authors, Da Sun. less Cancer Manag Res, 2020 Oct 30; 12. PMID: 33116895 Free PMC article. Review.
Checkpoint therapeutic target database (CKTTD): the first comprehensive database for checkpoint targets and their modulators in cancer immunotherapy. Yixiao Zhang, Yuan Yao, +15 authors, Yongliang Yang. less J Immunother Cancer, 2020 Oct 29; 8(2). PMID: 33109630 Free PMC article.
Anti-human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation. Jessica Bridoux, Katrijn Broos, +11 authors, Catarina Xavier. less Biomolecules, 2020 Oct 03; 10(10). PMID: 33003481 Free PMC article.
Targeting Mitochondria in Melanoma. Sepideh Aminzadeh-Gohari, Daniela D Weber, +3 authors, Roland Lang. less Biomolecules, 2020 Oct 04; 10(10). PMID: 33007949 Free PMC article.
PD-L1 expression in regional lymph nodes and predictable roles in anti-cancer immune responses. Yoshihiro Komohara, Mamoru Harada, +2 authors, Koji Ohnishi, Keiichiro Kumamoto, Toshiyuki Nakayama. less J Clin Exp Hematop, 2020 Jul 10; 60(3). PMID: 32641599 Free PMC article.
EZH2 inhibition: a promising strategy to prevent cancer immune editing. Ning Kang, Mark Eccleston, +4 authors, Francesco Crea. less Epigenomics, 2020 Sep 18; 12(16). PMID: 32938196 Free PMC article. Review.
β-Catenin regulates tumor-derived PD-L1. Chuanhui Han, Yang-Xin Fu. J Exp Med, 2020 Aug 30; 217(11). PMID: 32860048 Free PMC article.
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy. Weimin Wang, Weiping Zou. Mol Cell, 2020 Oct 01; 80(3). PMID: 32997964 Free PMC article. Review.
Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors. Alexander B Zaslavsky, M P Adams, +18 authors, Ganesh S Palapattu. less Sci Rep, 2020 Nov 11; 10(1). PMID: 33168847 Free PMC article.
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies. Kaijian Zhou, Shu Guo, +2 authors, Fei Li, Qiang Sun, Guoxin Liang. less Front Cell Dev Biol, 2020 Nov 13; 8. PMID: 33178688 Free PMC article. Review.
Study and analysis of antitumor resistance mechanism of PD1/PD-L1 immune checkpoint blocker. Zhengyi Wang, Xiaoying Wu. Cancer Med, 2020 Sep 03; 9(21). PMID: 32875727 Free PMC article. Review.
Development of an IFNγ response-related signature for predicting the survival of cutaneous melanoma. Baohui Hu, Qian Wei, +8 authors, Lin Zhao. less Cancer Med, 2020 Sep 10; 9(21). PMID: 32902917 Free PMC article.
Prognostic and clinicopathological significance of PD-1 expression in hepatocellular carcinoma: a meta-analysis. Qian Zhang, Kexiang Zhou, Wei Liang, Wei Xiong. J Int Med Res, 2020 Oct 27; 48(10). PMID: 33100077 Free PMC article.
TMEM205 Is an Independent Prognostic Factor and Is Associated With Immune Cell Infiltrates in Hepatocellular Carcinoma. Jiawei Rao, Xukun Wu, +2 authors, Xiaozhuan Zhou, Ronghai Deng, Yi Ma. less Front Genet, 2020 Nov 17; 11. PMID: 33193690 Free PMC article.
The Resistance Mechanisms of Lung Cancer Immunotherapy. Fen Wang, Shubin Wang, Qing Zhou. Front Oncol, 2020 Nov 17; 10. PMID: 33194652 Free PMC article. Review.
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KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression. Xiao Albert Zhou, Jiadong Zhou, +13 authors, Jiadong Wang. less Proc Natl Acad Sci U S A, 2020 Oct 29; 117(45). PMID: 33109719 Free PMC article.
Efficacy and safety of anti-PD-1/anti-PD-L1 antibody therapy in treatment of advanced gastric cancer or gastroesophageal junction cancer: A meta-analysis. Li Yang, Xian-Zhe Dong, +3 authors, Xiao-Xuan Xing, Xiao-Hui Cui, Lin Li, Lan Zhang. less World J Gastrointest Oncol, 2020 Dec 01; 12(11). PMID: 33250966 Free PMC article.
Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy. Weiqiang Zhou, Shanchun Guo, +2 authors, Mingli Liu, Matthew E Burow, Guangdi Wang. less Curr Med Chem, 2017 Sep 07; 26(17). PMID: 28875842 Free PMC article. Review.
Bad company: Microenvironmentally mediated resistance to targeted therapy in melanoma. Filipe V Almeida, Stephen M Douglass, Mitchell E Fane, Ashani T Weeraratna. Pigment Cell Melanoma Res, 2018 Sep 15; 32(2). PMID: 30216694 Free PMC article. Review.
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization. Miguel F Sanmamed, Lieping Chen. Cell, 2018 Oct 06; 175(2). PMID: 30290139 Free PMC article. Highly Cited. Review.
Programmed cell death protein-1 (PD-1)/programmed death-ligand-1 (PD-L1) axis in hepatocellular carcinoma: prognostic and therapeutic perspectives. T Mocan, Z Sparchez, +2 authors, R Craciun, C N Bora, D C Leucuta. less Clin Transl Oncol, 2018 Nov 06; 21(6). PMID: 30387047 Review.
The clinicopathological and prognostic value of programmed death-ligand 1 in colorectal cancer: a meta-analysis. X Ni, X Sun, +5 authors, J Suo. less Clin Transl Oncol, 2018 Nov 06; 21(5). PMID: 30392153
The correlation and prognostic value of serum levels of soluble programmed death protein 1 (sPD-1) and soluble programmed death-ligand 1 (sPD-L1) in patients with hepatocellular carcinoma. Boyang Chang, Tao Huang, +9 authors, Peihong Wu. less Cancer Immunol Immunother, 2018 Dec 07; 68(3). PMID: 30506460 Free PMC article.
Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer: a systematic review and meta-analysis. Zefeng Shen, Lihu Gu, +2 authors, Danyi Mao, Manman Chen, Rongjia Jin. less World J Surg Oncol, 2019 Jan 06; 17(1). PMID: 30609938 Free PMC article. Systematic Review.
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases. Zhen Xiang, Yingyan Yu. Front Med, 2019 Jan 20; 13(1). PMID: 30659409 Review.
The importance of the PD-1/PD-L1 pathway at the maternal-fetal interface. Matyas Meggyes, Eva Miko, +2 authors, Brigitta Szigeti, Nelli Farkas, Laszlo Szereday. less BMC Pregnancy Childbirth, 2019 Feb 21; 19(1). PMID: 30782114 Free PMC article.
Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells. Vladimir N Ivanov, Jinhua Wu, Tony J C Wang, Tom K Hei. Oncotarget, 2019 Feb 21; 10(8). PMID: 30783513 Free PMC article.
Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis. Yan Tie, Hui Yang, +4 authors, Ming Liu. less Drug Des Devel Ther, 2019 Feb 23; 13. PMID: 30787594 Free PMC article. Systematic Review.
Isolation of Tumor-Infiltrating Lymphocytes by Ficoll-Paque Density Gradient Centrifugation. Yee Sun Tan, Yu L Lei. Methods Mol Biol, 2019 Feb 25; 1960. PMID: 30798524 Free PMC article.
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives. Yumeng Wang, Guiling Li. Front Med, 2019 Mar 04; 13(4). PMID: 30826965 Review.
Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade. Linan Fang, Dalam Ly, +7 authors, Li Zhang. less J Exp Clin Cancer Res, 2019 Mar 13; 38(1). PMID: 30857561 Free PMC article.
Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function. Dallas Jones, Christina N Como, +7 authors, Maria A Nagel. less PLoS Pathog, 2019 Mar 15; 15(3). PMID: 30870532 Free PMC article.
The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer. Jiajing Cai, Qi Qi, +4 authors, Rong Xia. less J Cancer Res Clin Oncol, 2019 Apr 10; 145(6). PMID: 30963235 Review.
Glial Cell Expression of PD-L1. Priyanka Chauhan, James R Lokensgard. Int J Mol Sci, 2019 Apr 17; 20(7). PMID: 30987269 Free PMC article. Review.
Prognostic effect of programmed death-ligand 1 (PD-L1) in ovarian cancer: a systematic review, meta-analysis and bioinformatics study. Lin Wang. J Ovarian Res, 2019 May 02; 12(1). PMID: 31039792 Free PMC article. Systematic Review.
Analysis of the transcriptomic features of microsatellite instability subtype colon cancer. Haiwei Wang, Xinrui Wang, +2 authors, Liangpu Xu, Ji Zhang, Hua Cao. less BMC Cancer, 2019 Jun 22; 19(1). PMID: 31221124 Free PMC article.
Transcriptional suppression of the miR-15/16 family by c-Myc in malignant pleural mesothelioma. Marissa Williams, Yuen Yee Cheng, +7 authors, Glen Reid. less Oncotarget, 2019 Jul 11; 10(41). PMID: 31289611 Free PMC article.
MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function. Hyun Kyung Ahn, Sehui Kim, +5 authors, Yoon Kyung Jeon. less Int J Mol Sci, 2019 Sep 05; 20(17). PMID: 31480591 Free PMC article.
Advances in engineering local drug delivery systems for cancer immunotherapy. Peter Abdou, Zejun Wang, +4 authors, Zhen Gu. less Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020 Apr 08; 12(5). PMID: 32255276 Free PMC article. Review.
Targeted Delivery of CXCL9 and OX40L by Mesenchymal Stem Cells Elicits Potent Antitumor Immunity. Pan Yin, Liming Gui, +6 authors, Wei-Qiang Gao. less Mol Ther, 2020 Aug 23; 28(12). PMID: 32827461 Free PMC article.
Heparanase and the hallmarks of cancer. Krishnath M Jayatilleke, Mark D Hulett. J Transl Med, 2020 Dec 02; 18(1). PMID: 33256730 Free PMC article. Review.
Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities. Minhong Shen, Yibin Kang. Genes Dev, 2020 Dec 03; 34(23-24). PMID: 33262145 Free PMC article. Review.
Comprehensive analysis of cutaneous and uveal melanoma liver metastases. Esmee P Hoefsmit, Elisa A Rozeman, +18 authors, Christian U Blank. less J Immunother Cancer, 2020 Dec 03; 8(2). PMID: 33262254 Free PMC article.
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy. Yuka Igarashi, Tetsuro Sasada. J Immunol Res, 2020 Dec 08; 2020. PMID: 33282961 Free PMC article. Review.
PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo. Qibin Liao, Yunyu Mao, +3 authors, Jianqing Xu. less Biomark Res, 2020 Dec 10; 8(1). PMID: 33292688 Free PMC article.
Sintilimab: A Promising Anti-Tumor PD-1 Antibody. Lin Zhang, Wuqian Mai, Wenyang Jiang, Qing Geng. Front Oncol, 2020 Dec 17; 10. PMID: 33324564 Free PMC article. Review.
PD-L1-Mediated Immunosuppression in Glioblastoma Is Associated With the Infiltration and M2-Polarization of Tumor-Associated Macrophages. Zhiyuan Zhu, Hongbo Zhang, +4 authors, Mengqi Gao. less Front Immunol, 2020 Dec 18; 11. PMID: 33329573 Free PMC article.
A20 regulates the therapeutic effect of anti-PD-1 immunotherapy in melanoma. Weinan Guo, Jinyuan Ma, +17 authors, Chunying Li. less J Immunother Cancer, 2020 Dec 11; 8(2). PMID: 33298620 Free PMC article.
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5. Yang Liu, Xiaojia Liu, +7 authors, Hongbin Deng. less Acta Pharm Sin B, 2020 Dec 24; 10(12). PMID: 33354502 Free PMC article.
Multi-Omics and Informatics Analysis of FFPE Tissues Derived from Melanoma Patients with Long/Short Responses to Anti-PD1 Therapy Reveals Pathways of Response. Saurabh K Garg, Eric A Welsh, +7 authors, Joseph Markowitz. less Cancers (Basel), 2020 Dec 02; 12(12). PMID: 33255891 Free PMC article.
Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer. Laura C Zanetti-Domingues, Scott E Bonner, +2 authors, Veronica Huber. less Cells, 2020 Dec 12; 9(12). PMID: 33302515 Free PMC article. Review.
Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators. Tilahun Ayane Debele, Cheng-Fa Yeh, Wen-Pin Su. Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33333816 Free PMC article. Review.
Nanobodies as Versatile Tool for Multiscale Imaging Modalities. Marco Erreni, Tilo Schorn, Francesca D'Autilia, Andrea Doni. Biomolecules, 2020 Dec 24; 10(12). PMID: 33353213 Free PMC article. Review.
Tumor-Associated Macrophages in Tumor Immunity. Yueyun Pan, Yinda Yu, Xiaojian Wang, Ting Zhang. Front Immunol, 2020 Dec 29; 11. PMID: 33365025 Free PMC article. Review.
Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Qian Wu, Li Jiang, +3 authors, Si-Cheng Li, Qiao-Jun He, Bo Yang, Ji Cao. less Acta Pharmacol Sin, 2020 Mar 11; 42(1). PMID: 32152439 Free PMC article. Review.
Programmed cell death 1 (PDCD1) gene haplotypes and susceptibility of patients to basal cell carcinoma. Farshid Fathi, Batool Zamani, +4 authors, Hossein Motedayyen. less Mol Biol Rep, 2021 Jan 04; 48(3). PMID: 33389528
Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma. Jiaqing Yi, Xuanming Shi, Zhenyu Xuan, Jiang Wu. Cancer Lett, 2020 Dec 01; 499. PMID: 33253789 Free PMC article.
From biomarkers to therapeutic targets: the promise of PD-L1 in thyroid autoimmunity and cancer. Grégoire D'Andréa, Sandra Lassalle, +2 authors, Nicolas Guevara, Baharia Mograbi, Paul Hofman. less Theranostics, 2021 Jan 05; 11(3). PMID: 33391536 Free PMC article. Review.
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Jiali Yu, Michael D Green, +37 authors, Weiping Zou. less Nat Med, 2021 Jan 06; 27(1). PMID: 33398162 Free PMC article.
Epigenetic modulation of immunotherapy and implications in head and neck cancer. Liye Zhou, Na Xu, +2 authors, Hirofumi Shibata, Vassiliki Saloura, Ravindra Uppaluri. less Cancer Metastasis Rev, 2021 Jan 07; 40(1). PMID: 33403469 Free PMC article. Review.
AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL. Zuoqiao Wu, Mary Nicoll, Robert J Ingham. Exp Hematol Oncol, 2021 Jan 09; 10(1). PMID: 33413671 Free PMC article. Review.
Host tissue determinants of tumour immunity. Hélène Salmon, Romain Remark, Sacha Gnjatic, Miriam Merad. Nat Rev Cancer, 2019 Mar 15; 19(4). PMID: 30867580 Free PMC article. Highly Cited. Review.
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Rilin Deng, Chaohui Zuo, +24 authors, Haizhen Zhu. less Cell Mol Immunol, 2020 Sep 24; 17(11). PMID: 32963356 Free PMC article.
Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens. Yukie Kashima, Yosuke Togashi, +20 authors, Toshihiko Doi. less Sci Rep, 2021 Jan 13; 11(1). PMID: 33431933 Free PMC article.
RAS-targeted therapies: is the undruggable drugged? Amanda R Moore, Scott C Rosenberg, Frank McCormick, Shiva Malek. Nat Rev Drug Discov, 2020 Jun 13; 19(8). PMID: 32528145 Free PMC article. Review.
The Network of Cytokines in Brain Metastases. Jawad Fares, Alex Cordero, Deepak Kanojia, Maciej S Lesniak. Cancers (Basel), 2021 Jan 21; 13(1). PMID: 33466236 Free PMC article. Review.
Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles. Zhaohan Wei, Xiaoqiong Zhang, +13 authors, Xiangliang Yang. less Nat Commun, 2021 Jan 21; 12(1). PMID: 33469052 Free PMC article.
The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1. Hui Li, Xinwei Kuang, +16 authors, Xiang Chen. less Adv Sci (Weinh), 2021 Jan 30; 8(2). PMID: 33510997 Free PMC article.
Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors. Xingxing Yuan, Zujun Sun, +6 authors, Min Yu. less Invest New Drugs, 2020 Aug 11; 39(1). PMID: 32772342
DNA-protein biomarkers for immunotherapy in the era of precision oncology. Binnari Kim, So Young Kang, Kyoung-Mee Kim. J Pathol Transl Med, 2020 Nov 07; 55(1). PMID: 33153244 Free PMC article. Review.
Mesenchymal traits at the convergence of tumor-intrinsic and -extrinsic mechanisms of resistance to immune checkpoint blockers. Paola Trono, Antonella Sistigu, +2 authors, Belinda Palermo, Gennaro Ciliberto, Paola Nisticò. less Emerg Top Life Sci, 2017 Dec 12; 1(5). PMID: 33525801 Free PMC article.
Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades. Jun-Yan Li, Yu-Pei Chen, +2 authors, Ying-Qin Li, Na Liu, Jun Ma. less Mol Cancer, 2021 Feb 06; 20(1). PMID: 33541368 Free PMC article. Review.
PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia. Bola S Hanna, Philipp M Roessner, +6 authors, Martina Seiffert. less Leukemia, 2018 Dec 24; 33(6). PMID: 30573773
PD-L1 Is an Independent Prognostic Marker in Middle Eastern PTC and Its Expression Is Upregulated by BRAFV600E Mutation. Abdul K Siraj, Sandeep Kumar Parvathareddy, +4 authors, Khawla S Al-Kuraya. less Cancers (Basel), 2021 Feb 05; 13(3). PMID: 33535609 Free PMC article.
Development and External Validation of a Novel Immune Checkpoint-Related Gene Signature for Prediction of Overall Survival in Hepatocellular Carcinoma. Enfa Zhao, Shimin Chen, Ying Dang. Front Mol Biosci, 2021 Feb 09; 7. PMID: 33553243 Free PMC article.
Programmed Cell Death-One Inhibition Therapy in Classical Hodgkin Lymphoma. Samer A Al-Hadidi, Hubert H Chuang, Roberto N Miranda, Hun Ju Lee. Clin Lymphoma Myeloma Leuk, 2020 Nov 09; 21(2). PMID: 33160934 Free PMC article. Review.
Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation. Sandeep Kumar Parvathareddy, Abdul K Siraj, +3 authors, Khawla S Al-Kuraya. less Sci Rep, 2021 Feb 14; 11(1). PMID: 33580098 Free PMC article.
Immune landscape and therapeutic strategies: new insights into PD-L1 in tumors. Yuan Wei, Xiao Xiao, +2 authors, Xiang-Ming Lao, Limin Zheng, Dong-Ming Kuang. less Cell Mol Life Sci, 2020 Sep 18; 78(3). PMID: 32940722 Review.
The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy. Zhixiao Fang, Chunjie Jiang, Shengli Li. Front Immunol, 2021 Feb 23; 11. PMID: 33613544 Free PMC article. Review.
A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy. Joel Crespo, Yi Ting Koh, +5 authors, Robert J Benschop. less PLoS One, 2021 Feb 18; 16(2). PMID: 33596227 Free PMC article.
Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy. Xuefei Zhou, Yun Liu, +3 authors, Leaf Huang. less Sci Adv, 2021 Feb 19; 7(8). PMID: 33597232 Free PMC article.
Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy. Weiqin Jiang, Yinjun He, +9 authors, Hanju Hua. less Front Immunol, 2021 Feb 27; 11. PMID: 33633741 Free PMC article. Review.
PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer. Sandeep Kumar Parvathareddy, Abdul K Siraj, +6 authors, Khawla S Al-Kuraya. less Cells, 2021 Jan 29; 10(2). PMID: 33503961 Free PMC article.
Tissue-resident memory-like T cells in tumor immunity: Clinical implications. Madhav V Dhodapkar, Kavita M Dhodapkar. Semin Immunol, 2020 Oct 05; 49. PMID: 33011063 Free PMC article. Review.
Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway. Thamiris Becker Scheffel, Nathália Grave, +3 authors, Fernanda Bueno Morrone. less Front Oncol, 2021 Mar 05; 10. PMID: 33659213 Free PMC article. Review.
CRISPR/Cas9 for the Clinician: Current uses of gene editing and applications for new therapeutics in oncology. Julia Boland, Elena Nedelcu. Perm J, 2021 Jan 24; 24. PMID: 33482972 Free PMC article. Review.
Abscopal Effect of Frozen Autograft Reconstruction Combined with an Immune Checkpoint Inhibitor Analyzed Using a Metastatic Bone Tumor Model. Noritaka Yonezawa, Hideki Murakami, +14 authors, Hiroyuki Tsuchiya. less Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33671258 Free PMC article.
Effects of programmed death ligand 1 on the prognosis of neuroblastoma: A protocol for systematic review and meta analysis. Zelin Wu, Fenggui Wei, Yawei Zou. Medicine (Baltimore), 2021 Mar 04; 100(9). PMID: 33655954 Free PMC article. Systematic Review.
Prediction of Clinical Outcome in Locally Advanced Non-Small Cell Lung Cancer Patients Treated With Chemoradiotherapy by Plasma Markers. Xin Sui, Leilei Jiang, +9 authors, Weihu Wang. less Front Oncol, 2021 Mar 09; 10. PMID: 33680949 Free PMC article.
The Impact of Programmed Death-Ligand 1 Expression on the Prognosis of Early Stage Resected Non-Small Cell Lung Cancer: A Meta-Analysis of Literatures. Tao Shi, Shuai Zhu, +8 authors, Song Xu. less Front Oncol, 2021 Mar 13; 11. PMID: 33708622 Free PMC article. Systematic Review.
Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer. Guo-Qiang Zhang, Qiong Jiao, +4 authors, Quan-Yong Luo. less Cancer Sci, 2020 Nov 29; 112(3). PMID: 33247999 Free PMC article.
Inhibition of galectin-3 augments the antitumor efficacy of PD-L1 blockade in non-small-cell lung cancer. Hongxin Zhang, Pengfei Liu, +4 authors, Jianhui Cai. less FEBS Open Bio, 2021 Jan 18; 11(3). PMID: 33455075 Free PMC article.
Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. Yuan Hong, Yingcai Feng, +12 authors, Ye Liu. less FEBS Open Bio, 2021 Feb 03; 11(3). PMID: 33527708 Free PMC article.
PD-1 restrains IL-17A production from γδ T cells to modulate acute radiation-induced lung injury. Yuling Sheng, Kun Chen, +6 authors, Hua Ren. less Transl Lung Cancer Res, 2021 Mar 16; 10(2). PMID: 33718014 Free PMC article.
Identification of an epigenetic prognostic signature for patients with lower-grade gliomas. Hai Yu, Duanni Zhang, Minxue Lian. CNS Neurosci Ther, 2021 Jan 19; 27(4). PMID: 33459509 Free PMC article.
Diagnostic Value of Vaginal Microecology, Serum miR-18a, and PD-L1 for Identifying HPV-Positive Cervical Cancer. Yumei Zhang, Sujuan Qiu, +3 authors, Yueli Guo, Jiaqin Zhang, Xiaoqing Wu, Guolin Hong. less Technol Cancer Res Treat, 2021 Feb 27; 20. PMID: 33632085 Free PMC article.
Current developments of targeting the p53 signaling pathway for cancer treatment. Jing Huang. Pharmacol Ther, 2020 Nov 02; 220. PMID: 33130194 Free PMC article. Review.
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy. Deyi Zhang, Ryan M Reyes, +12 authors, Tyler J Curiel. less Cancer Med, 2021 Feb 25; 10(6). PMID: 33626233 Free PMC article.
Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity. Aiqin Gao, Xia Liu, +7 authors, Guangyong Peng. less J Immunother Cancer, 2021 Mar 04; 9(3). PMID: 33653799 Free PMC article.
Tumor Microenvironment Analysis Identified Subtypes Associated With the Prognosis and the Tumor Response to Immunotherapy in Bladder Cancer. Hongxian Zhang, Jiwen Song, +5 authors, Lulin Ma. less Front Genet, 2021 Mar 19; 12. PMID: 33732281 Free PMC article.
Preclinical analysis of novel prognostic transcription factors and immune-related gene signatures for bladder cancer via TCGA-based bioinformatic analysis. Yuyou Deng, Xin Hong, +5 authors, Xiaofeng Wang. less Oncol Lett, 2021 Mar 23; 21(5). PMID: 33747201 Free PMC article.
Cytosolic Delivery of Thiolated Neoantigen Nano-Vaccine Combined with Immune Checkpoint Blockade to Boost Anti-Cancer T Cell Immunity. Da Zhang, Ziguo Lin, +12 authors, Xiaolong Liu. less Adv Sci (Weinh), 2021 Mar 23; 8(6). PMID: 33747739 Free PMC article.
Tumor microenvironment characterization in triple-negative breast cancer identifies prognostic gene signature. Yan Qin, Jiehua Deng, +3 authors, Qiuyun Li. less Aging (Albany NY), 2021 Feb 05; 13(4). PMID: 33536349 Free PMC article.
Autophagy in tumour immunity and therapy. Houjun Xia, Douglas R Green, Weiping Zou. Nat Rev Cancer, 2021 Mar 25; 21(5). PMID: 33758415 Free PMC article. Review.
PD-L1 Expression Is an Independent Marker for Lymph Node Metastasis in Middle Eastern Endometrial Cancer. Abdul K Siraj, Sandeep Kumar Parvathareddy, +5 authors, Khawla S Al-Kuraya. less Diagnostics (Basel), 2021 Mar 07; 11(3). PMID: 33669153 Free PMC article.
Tissue-resident memory T cells in tumor immunity and immunotherapy. Karolina Okła, Donna L Farber, Weiping Zou. J Exp Med, 2021 Mar 24; 218(4). PMID: 33755718 Free PMC article. Review.
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing. Zhiru Wang, Wenting Kang, +7 authors, Hong-Min Liu. less Acta Pharm Sin B, 2021 Mar 30; 11(3). PMID: 33777676 Free PMC article.
Progress and Challenges of Predictive Biomarkers for Immune Checkpoint Blockade. Yanna Lei, Xiaoying Li, +2 authors, Qian Huang, Xiufeng Zheng, Ming Liu. less Front Oncol, 2021 Mar 30; 11. PMID: 33777757 Free PMC article. Review.
Aging, cancer, and antitumor immunity. Hideki Ikeda, Yosuke Togashi. Int J Clin Oncol, 2021 Mar 31; 27(2). PMID: 33783658 Review.
Immunotherapy and predictive immunologic profile: the tip of the iceberg. Tatiana Cunha Pereira, Paulo Rodrigues-Santos, +7 authors, Gabriela Sousa. less Med Oncol, 2021 Apr 01; 38(5). PMID: 33788049 Review.
Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy. Xiang Ling, Wenbo Han, +5 authors, Wenbin Lin. less Biomaterials, 2021 Feb 10; 270. PMID: 33561626 Free PMC article.
CD169 Expression on Lymph Node Macrophages Predicts in Patients With Gastric Cancer. Keiichiro Kumamoto, Takashi Tasaki, +5 authors, Toshiyuki Nakayama. less Front Oncol, 2021 Apr 06; 11. PMID: 33816277 Free PMC article.
Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma. Barbara Azzimonti, Luca Raimondo, +10 authors, Guido Valente. less Ann Med, 2021 Mar 27; 53(1). PMID: 33769181 Free PMC article.
Type I and II Interferons in the Anti-Tumor Immune Response. Sarah E Fenton, Diana Saleiro, Leonidas C Platanias. Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33801234 Free PMC article. Review.
Early Evaluation of Immunotherapy Response in Lymphoma Patients by 18F-FDG PET/CT: A Literature Overview. Cristina Ferrari, Nicola Maggialetti, +4 authors, Giuseppe Rubini. less J Pers Med, 2021 Apr 04; 11(3). PMID: 33803667 Free PMC article. Review.
Quantitative Assessment of CD200 and CD200R Expression in Lung Cancer. Ioannis A Vathiotis, Tyler MacNeil, +8 authors, David L Rimm. less Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33804482 Free PMC article.
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity. Jiajia Zhou, Ilona Kryczek, +17 authors, Weiping Zou. less Nat Immunol, 2021 Mar 27; 22(4). PMID: 33767425 Free PMC article.
Remodels the Immunosuppressive Tumor Microenvironment by Combination of Bacillus Calmette-Guérin and Anti-PD-L1 in an Orthotopic Triple-Negative Breast Cancer Mouse Model. Yuan Lu, Xin Huang, +5 authors, Wenbo He. less Onco Targets Ther, 2021 Apr 10; 14. PMID: 33833524 Free PMC article.
An unexpected role for p53 in regulating cancer cell-intrinsic PD-1 by acetylation. Zhijie Cao, Ning Kon, +9 authors, Donglai Wang. less Sci Adv, 2021 Apr 02; 7(14). PMID: 33789902 Free PMC article.
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance. Heng Lin, Ilona Kryczek, +23 authors, Weiping Zou. less Cancer Cell, 2021 Jan 30; 39(4). PMID: 33513345 Free PMC article.
Bioinformatics and survival analysis of glia maturation factor-γ in pan-cancers. Aihua Lan, Chunxia Ren, +2 authors, Xiaoling Wang, Guoqing Tong, Gong Yang. less BMC Cancer, 2021 Apr 18; 21(1). PMID: 33863293 Free PMC article.
SQ3370 Activates Cytotoxic Drug via Click Chemistry at Tumor and Elicits Sustained Responses in Injected & Non-injected Lesions. S Srinivasan, N A Yee, +4 authors, J M Mejia Oneto. less Adv Ther (Weinh), 2021 Apr 20; 4(3). PMID: 33869738 Free PMC article.
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases. Sulaiman S Alhudaithi, Rashed M Almuqbil, +5 authors, Sandro R P da Rocha. less Mol Pharm, 2020 Nov 11; 17(12). PMID: 33170724 Free PMC article.
Decreased expression of programmed death-1 on CD8+ effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes. Yimei Shan, Yinghong Kong, +11 authors, Ji Hu. less Acta Diabetol, 2021 Apr 24; 58(9). PMID: 33890177
EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer. Katherine L Morel, Anjali V Sheahan, +34 authors, Leigh Ellis. less Nat Cancer, 2021 Apr 27; 2(4). PMID: 33899001 Free PMC article.
Frontiers and Opportunities: Highlights of the 2nd Annual Conference of the Chinese Antibody Society. Hongyu Zhang, Mi Deng, +5 authors, Mitchell Ho. less Antib Ther, 2018 Nov 09; 1(2). PMID: 30406214 Free PMC article.
Absence of association between pretransplant serum soluble programmed death protein-1 level and prognosis following living donor liver transplantation in patients with hepatocellular carcinoma. Byeong-Gon Na, Yun Kyu Kim, +13 authors, Sung-Gyu Lee. less Medicine (Baltimore), 2021 Apr 29; 100(17). PMID: 33907121 Free PMC article.
Programmed Death Ligand-1 (PD-L1) Is an Independent Negative Prognosticator in Western-World Gallbladder Cancer. Thomas Albrecht, Fritz Brinkmann, +12 authors, Benjamin Goeppert. less Cancers (Basel), 2021 May 01; 13(7). PMID: 33918309 Free PMC article.
Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy. Diedie Li, Chengzhi Gao, +5 authors, Jing Xie. less Molecules, 2021 May 01; 26(8). PMID: 33921892 Free PMC article. Review.
Nanoparticle-based approaches to target the lymphatic system for antitumor treatment. Xingzhou Peng, Junjie Wang, +2 authors, Feifan Zhou, Qian Liu, Zhihong Zhang. less Cell Mol Life Sci, 2021 May 09; 78(12). PMID: 33963442 Review.
Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity. Yiwen Zhang, Hongrong Hu, +12 authors, Hui Zhang. less J Immunother Cancer, 2021 Apr 23; 9(4). PMID: 33883257 Free PMC article.
Myeloid-derived suppressor cells regulate the immunosuppressive functions of PD-1-PD-L1+ Bregs through PD-L1/PI3K/AKT/NF-κB axis in breast cancer. Min Liu, Feng Wei, +7 authors, Qian Sun. less Cell Death Dis, 2021 May 11; 12(5). PMID: 33967272 Free PMC article.
Functional bionanomaterials for cell surface engineering in cancer immunotherapy. Sheng Ma, Yudi Xu, Wantong Song. APL Bioeng, 2021 May 14; 5(2). PMID: 33981940 Free PMC article. Review.
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy. Gaopeng Li, Ilona Kryczek, +15 authors, Weiping Zou. less Nat Cell Biol, 2021 May 08; 23(5). PMID: 33958760 Free PMC article.
Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients. Kaifeng Jin, Yifan Cao, +13 authors, Jiejie Xu. less Oncoimmunology, 2021 May 18; 10(1). PMID: 33996266 Free PMC article.
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress. Wuchang Zhang, Wei Liu, +5 authors, Cun-Yu Wang. less Mol Cell, 2021 Mar 21; 81(10). PMID: 33743195 Free PMC article.
A preclinical study: correlation between PD-L1 PET imaging and the prediction of therapy efficacy of MC38 tumor with 68Ga-labeled PD-L1 targeted nanobody. Songbing Qin, Yang Yu, +7 authors, Xiaorong Sun. less Aging (Albany NY), 2021 Apr 29; 13(9). PMID: 33910164 Free PMC article.
Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study. Nikolaus B Wagner, Max M Lenders, +36 authors, Thomas K Eigentler. less J Immunother Cancer, 2021 May 15; 9(5). PMID: 33986126 Free PMC article.
The Genomic Landscape of Thyroid Cancer Tumourigenesis and Implications for Immunotherapy. Amandeep Singh, Jeehoon Ham, +3 authors, Cheok Soon Lee. less Cells, 2021 Jun 03; 10(5). PMID: 34062862 Free PMC article. Review.
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. Xiaoming Dai, Xia Bu, +14 authors, Wenyi Wei. less Mol Cell, 2021 Apr 29; 81(11). PMID: 33909988 Free PMC article.
Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma. Thanpisit Lomphithak, Perawatt Akara-Amornthum, +7 authors, Siriporn Jitkaew. less Sci Rep, 2021 Jun 05; 11(1). PMID: 34083572 Free PMC article.
CAR T-cell therapy for pleural mesothelioma: Rationale, preclinical development, and clinical trials. Navin K Chintala, David Restle, +5 authors, Prasad S Adusumilli. less Lung Cancer, 2021 May 12; 157. PMID: 33972125 Free PMC article. Review.
Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas. Farah Succaria, Pia Kvistborg, +10 authors, Janis M Taube. less Cancer Immunol Immunother, 2020 Oct 31; 70(5). PMID: 33125511 Free PMC article.
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1. Dan Zhu, Ruidan Xu, +4 authors, Xiaofeng Zheng. less Cell Death Differ, 2020 Dec 18; 28(6). PMID: 33328570 Free PMC article.
A size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids. Jiaolin Wen, Neng Qiu, +6 authors, Lijuan Chen. less Drug Deliv, 2021 Jun 04; 28(1). PMID: 34078185 Free PMC article.
Mechanism-based treatment of cancer with immune checkpoint inhibitor therapies. Yara Abdou, Manu Pandey, +3 authors, Marc S Ernstoff. less Br J Clin Pharmacol, 2020 Apr 24; 86(9). PMID: 32323342 Free PMC article. Review.
Precise medicine of programmed cell death-1/programmed cell death 1 ligand 1 inhibitor immunotherapy combined radiotherapy for inoperable advanced lung cancer: A protocol for systematic review and meta-analysis. Gang Liu, Xiaolan Lv, Yanling Ding, Yongbo Guo. Medicine (Baltimore), 2021 Jun 16; 100(24). PMID: 34128893 Free PMC article.
Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer. Yanlei Liu, Jingxing Yang, +9 authors, Daxiang Cui. less Nanomicro Lett, 2021 Jun 18; 12(1). PMID: 34138126 Free PMC article.
Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis. Shanshan Gou, Shuai Wang, +10 authors, Yanfeng Gao. less Theranostics, 2021 Jun 24; 11(15). PMID: 34158852 Free PMC article.
Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker. Karima Oualla, Luis Castelo Branco, +4 authors, Nawfel Mellas. less Cancer Control, 2021 Apr 09; 28. PMID: 33827280 Free PMC article.
Critical role of the CD44lowCD62Llow CD8+ T cell subset in restoring antitumor immunity in aged mice. Yuka Nakajima, Kenji Chamoto, Takuma Oura, Tasuku Honjo. Proc Natl Acad Sci U S A, 2021 Jun 06; 118(23). PMID: 34088845 Free PMC article.
Non-cationic Material Design for Nucleic Acid Delivery. Ziwen Jiang, S Thayumanavan. Adv Ther (Weinh), 2020 Mar 01; 3(3). PMID: 34164572 Free PMC article.
Synthesis of Multifunctional Nanoparticles for the Combination of Photodynamic Therapy and Immunotherapy. Mei-Hwa Lee, James L Thomas, +3 authors, Hung-Yin Lin. less Pharmaceuticals (Basel), 2021 Jun 03; 14(6). PMID: 34073468 Free PMC article.
Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy. Julie Niogret, Hélène Berger, +15 authors, Fanny Chalmin. less J Immunother Cancer, 2021 Jun 10; 9(6). PMID: 34103351 Free PMC article.
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma. Lin Gao, Liliang Xia, +3 authors, Shun Lu. less Transl Oncol, 2021 Jun 16; 14(9). PMID: 34130052 Free PMC article.
Turning enemies into allies-reprogramming tumor-associated macrophages for cancer therapy. Martina Molgora, Marco Colonna. Med (N Y), 2021 Jul 01; 2(6). PMID: 34189494 Free PMC article. Review.
Icaritin inhibits PD-L1 expression by Targeting Protein IκB Kinase α. Dongliang Mo, Hai Zhu, +12 authors, Kun Meng. less Eur J Immunol, 2020 Dec 24; 51(4). PMID: 33354776 Free PMC article.
FXYD6 Regulates Chemosensitivity by Mediating the Expression of Na+/K+-ATPase α1 and Affecting Cell Autophagy and Apoptosis in Colorectal Cancer. Wen Luo, Qingan Liu, +5 authors, Xiangling Wang. less Biomed Res Int, 2021 Jul 03; 2021. PMID: 34212047 Free PMC article.
Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy. Hongbo Zhang, Yu Xia, +7 authors, Yi Zou. less Molecules, 2021 Jul 03; 26(11). PMID: 34199417 Free PMC article.
PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma. Takahiro Hongo, Hidetaka Yamamoto, +12 authors, Yoshinao Oda. less Mod Pathol, 2021 Jul 05; 34(11). PMID: 34218257
Checkpoint Inhibition Therapy in Transplant-Ineligible Relapsed or Refractory Classic Hodgkin Lymphoma. Samer A Al-Hadidi, Hun Ju Lee. JCO Oncol Pract, 2021 Jan 13; 17(2). PMID: 33434064 Free PMC article.
Consider the chemokines: a review of the interplay between chemokines and T cell subset function. Marianne Strazza, Adam Mor. Discov Med, 2017 Sep 28; 24(130). PMID: 28950073 Free PMC article. Review.
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab. Guoxu Zheng, Zhangyan Guo, +6 authors, Lintao Jia. less Signal Transduct Target Ther, 2021 Jun 24; 6(1). PMID: 34158475 Free PMC article.
Prognostic and Therapeutic Implications of Immune Classification by CD8+ Tumor-Infiltrating Lymphocytes and PD-L1 Expression in Sinonasal Squamous Cell Carcinoma. Rocío García-Marín, Sara Reda, +7 authors, Mario A Hermsen. less Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34203211 Free PMC article.
Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab. Toshiki Iwai, Masamichi Sugimoto, +7 authors, Osamu Kondoh. less Sci Rep, 2021 Jul 08; 11(1). PMID: 34230534 Free PMC article.
The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells. Zongcai Liu, Fen Ning, +9 authors, Li Liu. less Cancer Commun (Lond), 2021 Jul 09; 41(1). PMID: 34236149 Free PMC article.
Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy. Jiahuan Zou, Hongwei Xia, +5 authors, Feng Bi. less Cancer Sci, 2021 May 03; 112(7). PMID: 33934451 Free PMC article.
[Cardiotoxicity of Anti-PD-L1 Antibody and the Effect of Levothyroxine  in Attenuating the Related Mortality in Mice]. Zhenyin Chen, Min Wang, +3 authors, Sanhui Gao, Hua Guo, Guizhen Wang, Guangbiao Zhou. less Zhongguo Fei Ai Za Zhi, 2021 Jun 23; 24(6). PMID: 34157799 Free PMC article.
circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation. Lingfei Jia, Yilun Wang, Cun-Yu Wang. Adv Sci (Weinh), 2021 Jul 15; 8(13). PMID: 34258151 Free PMC article.
KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1. Rupal S Bhatt, Abdulla Berjis, +16 authors, Gordon J Freeman. less Cancer Immunol Res, 2020 Nov 25; 9(2). PMID: 33229411 Free PMC article.
Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death. Feiyang Jin, Di Liu, +2 authors, Xiaoling Xu, Jiansong Ji, Yongzhong Du. less Int J Nanomedicine, 2021 Jul 17; 16. PMID: 34267518 Free PMC article. Review.
Identification of mouse helper epitopes for WT1-specific CD4+ T cells. Hiroko Nakajima, Jun Nakata, +14 authors, Haruo Sugiyama. less Cancer Immunol Immunother, 2021 Jul 18; 70(11). PMID: 34272593
Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation. Wan Du, Fang Hua, +18 authors, Weiping Zou. less Cancer Discov, 2021 Feb 26; 11(7). PMID: 33627378 Free PMC article.
Immune Checkpoint Blockade for Metastatic Uveal Melanoma: Patterns of Response and Survival According to the Presence of Hepatic and Extrahepatic Metastasis. Elias A T Koch, Anne Petzold, +30 authors, On Behalf Of The German Dermatologic Cooperative Oncology Group DeCOG Committee Ocular Melanoma. less Cancers (Basel), 2021 Jul 21; 13(13). PMID: 34283061 Free PMC article.
Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential. Espen Basmo Ellingsen, Sara M Mangsbo, Eivind Hovig, Gustav Gaudernack. Front Immunol, 2021 Jul 23; 12. PMID: 34290704 Free PMC article. Review.
Mechanisms and Clinical Trials of Hepatocellular Carcinoma Immunotherapy. Shao-Li Huang, Yu-Ming Wang, +5 authors, Hong-Wu Xin. less Front Genet, 2021 Jul 27; 12. PMID: 34306031 Free PMC article. Review.
Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum. Priyanka Chakraborty, Emily L Chen, +3 authors, Jason A Somarelli. less Comput Struct Biotechnol J, 2021 Jul 27; 19. PMID: 34306571 Free PMC article.
The Efficacy of Anti-PD-L1 Treatment in Melanoma Is Associated with the Expression of the ECM Molecule EMILIN2. Albina Fejza, Maurizio Polano, +5 authors, Eva Andreuzzi. less Int J Mol Sci, 2021 Jul 25; 22(14). PMID: 34299131 Free PMC article.
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis. Constantinos Roufas, Ilias Georgakopoulos-Soares, Apostolos Zaravinos. NAR Cancer, 2021 Jul 29; 3(1). PMID: 34316699 Free PMC article.
A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment. A Farias, A Soto, +5 authors, P M Berguer. less Sci Rep, 2021 Jul 30; 11(1). PMID: 34321536 Free PMC article.
Current Trends of Immunotherapy in the Treatment of Cutaneous Melanoma: A Review. Piyu Parth Naik. Dermatol Ther (Heidelb), 2021 Aug 03; 11(5). PMID: 34339016 Free PMC article. Review.
ENO1 promotes antitumor immunity by destabilizing PD-L1 in NSCLC. Chunyi Zhang, Kunpeng Zhang, Jie Gu, Di Ge. Cell Mol Immunol, 2021 Jun 09; 18(8). PMID: 34099892 Free PMC article.
Cross-Link-Functionalized Nanoparticles for Rapid Excretion in Nanotheranostic Applications. Zhuoran Ma, Feifei Wang, +6 authors, Hongjie Dai. less Angew Chem Weinheim Bergstr Ger, 2021 Aug 03; 132(46). PMID: 34334834 Free PMC article.
NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Xiaozhen Zhang, Xing Huang, +10 authors, Tingbo Liang. less Nat Commun, 2021 Jul 29; 12(1). PMID: 34315872 Free PMC article.
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy. Qingyun Yuan, Qiaoyan Liang, +5 authors, Min Yu. less Oncoimmunology, 2021 Aug 06; 10(1). PMID: 34350059 Free PMC article.
Automated tumor proportion score analysis for PD-L1 (22C3) expression in lung squamous cell carcinoma. Jingxin Liu, Qiang Zheng, +14 authors, Yuan Li. less Sci Rep, 2021 Aug 07; 11(1). PMID: 34354151 Free PMC article.
ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer. Zongren Wang, Xueling Zhang, +11 authors, Lan Shao. less J Immunother Cancer, 2021 Jul 25; 9(7). PMID: 34301812 Free PMC article.
IFNγ signaling integrity in colorectal cancer immunity and immunotherapy. Wan Du, Timothy L Frankel, Michael Green, Weiping Zou. Cell Mol Immunol, 2021 Aug 14; 19(1). PMID: 34385592 Free PMC article. Review.
Histone deacetylase 2 knockout suppresses immune escape of triple-negative breast cancer cells via downregulating PD-L1 expression. Pengfei Xu, Wei Xiong, +3 authors, Yun Lin, Liping Fan, Hongchao Pan, Yaochen Li. less Cell Death Dis, 2021 Aug 09; 12(8). PMID: 34365463 Free PMC article.
Current status and quality of radiomic studies for predicting immunotherapy response and outcome in patients with non-small cell lung cancer: a systematic review and meta-analysis. Qiuying Chen, Lu Zhang, +7 authors, Shuixing Zhang. less Eur J Nucl Med Mol Imaging, 2021 Aug 18; 49(1). PMID: 34402924 Systematic Review.
Programmed Death Ligand 1 Is Overexpressed in Liver Macrophages in Chronic Liver Diseases, and Its Blockade Improves the Antibacterial Activity Against Infections. Elisa Pose, Mar Coll, +14 authors, Pere Ginès. less Hepatology, 2020 Nov 22; 74(1). PMID: 33219516 Free PMC article.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence. Ying Xu, Guan-Hua Su, +3 authors, Ding Ma, Yi Xiao, Zhi-Ming Shao, Yi-Zhou Jiang. less Signal Transduct Target Ther, 2021 Aug 22; 6(1). PMID: 34417437 Free PMC article. Review.
N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Zhenchuan Liu, Tingting Wang, +6 authors, Yongxin Zhou. less Mol Cancer, 2021 Aug 22; 20(1). PMID: 34416901 Free PMC article.
Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity. Yingzhong Li, Zhijun Su, +7 authors, Ron Weiss. less Nat Cancer, 2021 Aug 28; 1(9). PMID: 34447945 Free PMC article.
Role of the Immune System Elements in Pulmonary Arterial Hypertension. Michał Tomaszewski, Dominika Bębnowska, +4 authors, Ewelina Grywalska. less J Clin Med, 2021 Aug 28; 10(16). PMID: 34442052 Free PMC article. Review.
Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis. Edyta Zyla, Bogdan Musielak, Tad A Holak, Grzegorz Dubin. Molecules, 2021 Aug 28; 26(16). PMID: 34443436 Free PMC article.
PDL1-positive exosomes suppress antitumor immunity by inducing tumor-specific CD8+ T cell exhaustion during metastasis. Ji Chen, Yang Song, +6 authors, Xiaofeng Chen. less Cancer Sci, 2021 Jun 22; 112(9). PMID: 34152672 Free PMC article.
Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner. Kailiang Zhao, Qiang Zhang, +9 authors, Meredith A Morgan. less Mol Cancer Res, 2021 May 29; 19(9). PMID: 34045311 Free PMC article.
Immune Check Point Inhibitors in Primary Cutaneous T-Cell Lymphomas: Biologic Rationale, Clinical Results and Future Perspectives. Gabriele Roccuzzo, Silvia Giordano, +7 authors, Pietro Quaglino. less Front Oncol, 2021 Sep 07; 11. PMID: 34485162 Free PMC article. Review.
Direct and Indirect Regulators of Epithelial-Mesenchymal Transition-Mediated Immunosuppression in Breast Carcinomas. Anushka Dongre, Mohammad Rashidian, +8 authors, Robert A Weinberg. less Cancer Discov, 2020 Dec 18; 11(5). PMID: 33328216 Free PMC article.
The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy. Wenxiao Jiang, Shuya Pan, +2 authors, Xin Chen, Zhi-Wei Wang, Xueqiong Zhu. less Mol Cancer, 2021 Sep 10; 20(1). PMID: 34496886 Free PMC article. Review.
Ki-67 as a Prognostic Biomarker in Invasive Breast Cancer. Matthew G Davey, Sean O Hynes, +2 authors, Michael J Kerin, Nicola Miller, Aoife J Lowery. less Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503265 Free PMC article. Review.
Anticancer Activities of Hesperidin via Suppression of Up-Regulated Programmed Death-Ligand 1 Expression in Oral Cancer Cells. Benjawan Wudtiwai, Anupong Makeudom, +2 authors, Prachya Kongtawelert. less Molecules, 2021 Sep 11; 26(17). PMID: 34500779 Free PMC article.
Targeting the Microenvironment in Esophageal Cancer. Lei Wang, Huiqiong Han, +3 authors, Zehua Wang, Litong Shi, Mei Yang, Yanru Qin. less Front Cell Dev Biol, 2021 Sep 14; 9. PMID: 34513829 Free PMC article. Review.
Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges. Shu-Jin Li, Jia-Xian Chen, Zhi-Jun Sun. Cancer Commun (Lond), 2021 Jun 18; 41(9). PMID: 34137513 Free PMC article. Review.
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors. Brett Hopkins, Hongjun Zhang, +20 authors, Yongxin Han. less ACS Med Chem Lett, 2021 Sep 18; 12(9). PMID: 34531952 Free PMC article.
Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers. Ming Yi, Mengke Niu, +7 authors, Kongming Wu. less J Hematol Oncol, 2021 Sep 17; 14(1). PMID: 34526097 Free PMC article.
Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target. Wenjing Qian, Mingfang Zhao, Ruoyu Wang, Heming Li. J Hematol Oncol, 2021 Sep 17; 14(1). PMID: 34526102 Free PMC article. Review.
Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD. Felix Ritzmann, Kai Borchardt, +9 authors, Christoph Beisswenger. less Am J Physiol Lung Cell Mol Physiol, 2021 Mar 25; 320(5). PMID: 33759577 Free PMC article.
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy. Jinhua Liu, Zichao Chen, +3 authors, Yaqun Li, Wenjie Zhao, JiBiao Wu, Zhen Zhang. less Front Pharmacol, 2021 Sep 21; 12. PMID: 34539412 Free PMC article. Review.
Prevalence of programmed death ligand-1 in patients diagnosed with non-small cell lung cancer in Lebanon. Ghina Fakhri, Reem Akel, +6 authors, Arafat Tfayli. less SAGE Open Med, 2021 Sep 21; 9. PMID: 34540227 Free PMC article.
PD-L1-Mediated Immunosuppression in Oral Squamous Cell Carcinoma: Relationship With Macrophage Infiltration and Epithelial to Mesenchymal Transition Markers. Tiantian Wu, Caijin Tang, +3 authors, Cong Feng. less Front Immunol, 2021 Sep 24; 12. PMID: 34552581 Free PMC article.
Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases. Yuqi Zhang, Ziran Qin, +2 authors, Wenhuan Sun, Feng Chu, Fangfang Zhou. less Front Immunol, 2021 Sep 25; 12. PMID: 34557182 Free PMC article. Review.
Dynamic EMT: a multi-tool for tumor progression. Simone Brabletz, Harald Schuhwerk, Thomas Brabletz, Marc P Stemmler. EMBO J, 2021 Aug 31; 40(18). PMID: 34459003 Free PMC article. Review.
Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma. Zhuolun Sun, Changying Jing, +5 authors, Hanbo Wang. less Front Oncol, 2021 Sep 28; 11. PMID: 34568046 Free PMC article.
Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges. Guoqiang Sun, Dawei Rong, +7 authors, Yangbai Sun. less Front Cell Dev Biol, 2021 Sep 28; 9. PMID: 34568317 Free PMC article. Review.
Immune Checkpoints in Cancers: From Signaling to the Clinic. Céline Pisibon, Amira Ouertani, +2 authors, Corine Bertolotto, Robert Ballotti, Yann Cheli. less Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572799 Free PMC article. Review.
Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy. Pedro Bule, Sandra Isabel Aguiar, Frederico Aires-Da-Silva, Joana Nunes Ribeiro Dias. Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34575965 Free PMC article. Review.
Safety and Efficacy of Anti-CD19-Chimeric Antigen Receptor T Cell Combined With Programmed Cell Death 1 Inhibitor Therapy in a Patient With Refractory Post-Transplant Lymphoproliferative Disease: Case Report and Literature Review. Gang Feng, Qing Li, +4 authors, Qi Deng. less Front Oncol, 2021 Oct 05; 11. PMID: 34604065 Free PMC article.
B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer. Jiayu Wang, Hongya Wu, +9 authors, Tongguo Shi. less Cell Death Discov, 2021 Sep 20; 7(1). PMID: 34537815 Free PMC article.
Augmenting the therapeutic window of radiotherapy: A perspective on molecularly targeted therapies and nanomaterials. Moataz Reda, Alexander F Bagley, Husam Y Zaidan, Wassana Yantasee. Radiother Oncol, 2020 Jul 01; 150. PMID: 32598976 Free PMC article. Review.
Ferroptosis: A New Promising Target for Lung Cancer Therapy. Rui Xiong, Ruyuan He, +4 authors, Qing Geng. less Oxid Med Cell Longev, 2021 Oct 08; 2021. PMID: 34616505 Free PMC article. Review.
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β. Fu Du, Xin Qi, +6 authors, Jing Li. less Exp Mol Med, 2021 Sep 23; 53(9). PMID: 34548615 Free PMC article.
Microbiota and Colorectal Cancer: From Gut to Bedside. Miguel Silva, Valentina Brunner, Markus Tschurtschenthaler. Front Pharmacol, 2021 Oct 19; 12. PMID: 34658896 Free PMC article. Review.
Gram-negative microbiota is related to acute exacerbation in children with asthma. Yoon Hee Kim, Haerin Jang, +9 authors, Myung Hyun Sohn. less Clin Transl Allergy, 2021 Oct 21; 11(8). PMID: 34667591 Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang. less Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187 Free PMC article.
Multi-Omics Data Analyses Identify B7-H3 as a Novel Prognostic Biomarker and Predict Response to Immune Checkpoint Blockade in Head and Neck Squamous Cell Carcinoma. Wanzun Lin, Yanyan Xu, +6 authors, Jiade J Lu. less Front Immunol, 2021 Oct 23; 12. PMID: 34675936 Free PMC article.
Editorial: Genetic and Epigenetic Control of Immune Responses. Satish Kumar R Noonepalle, Lidia Karabon, Katherine B Chiappinelli, Alejandro Villagra. Front Immunol, 2021 Oct 23; 12. PMID: 34675944 Free PMC article.
Emerging concepts in PD-1 checkpoint biology. Kristen E Pauken, James A Torchia, +2 authors, Apoorvi Chaudhri, Arlene H Sharpe, Gordon J Freeman. less Semin Immunol, 2021 May 20; 52. PMID: 34006473 Free PMC article. Review.
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Kazuhiro Koikawa, Shin Kibe, +24 authors, Kun Ping Lu. less Cell, 2021 Aug 14; 184(18). PMID: 34388391 Free PMC article.
Immune checkpoint blockade in the treatment of malignant tumor: current statue and future strategies. Wenwen Yang, Caining Lei, +5 authors, Tiankang Guo. less Cancer Cell Int, 2021 Nov 04; 21(1). PMID: 34727927 Free PMC article. Review.
MET overexpression contributes to STAT4-PD-L1 signaling activation associated with tumor-associated, macrophages-mediated immunosuppression in primary glioblastomas. Qiang-Wei Wang, Li-Hua Sun, +13 authors, Zhao-Shi Bao. less J Immunother Cancer, 2021 Oct 21; 9(10). PMID: 34667077 Free PMC article.
Multiomics analysis of tumor mutational burden across cancer types. Lin Li, Long Bai, +6 authors, Keshuo Ding. less Comput Struct Biotechnol J, 2021 Nov 09; 19. PMID: 34745455 Free PMC article.
Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR. Xiaojia Liu, Mingxiao Yin, +7 authors, Hongbin Deng. less Acta Pharm Sin B, 2021 Nov 09; 11(10). PMID: 34745852 Free PMC article.
Predictive Value of Multiparametric MRI for Response to Single-Cycle Induction Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma. Konstantin Hellwig, Stephan Ellmann, +12 authors, Tobias Bäuerle. less Front Oncol, 2021 Nov 09; 11. PMID: 34745957 Free PMC article.
Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity. Jingya Guo, Yong Liang, +5 authors, Hua Peng. less Cell Res, 2021 Aug 12; 31(11). PMID: 34376814 Free PMC article.
Investigation of the relationship between immune checkpoints and mismatch repair deficiency in recurrent and nonrecurrent glioblastoma Emel Çakır, İsmail Saygın, Mustafa Emre Ercin. Turk J Med Sci, 2021 Feb 19; 51(4). PMID: 33600097 Free PMC article.
Neutrophils Extracellular Traps Inhibition Improves PD-1 Blockade Immunotherapy in Colorectal Cancer. Hongji Zhang, Yu Wang, +12 authors, Allan Tsung. less Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771497 Free PMC article.
Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy. Zaigang Zhou, Ning Jiang, +5 authors, Jianliang Shen. less J Nanobiotechnology, 2021 Nov 20; 19(1). PMID: 34794446 Free PMC article.
Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo. Huapan Fang, Zhaopei Guo, +5 authors, Xuesi Chen. less Nat Commun, 2021 Nov 20; 12(1). PMID: 34795289 Free PMC article.
Dl-3-N-Butylphthalide Presents Anti-Cancer Activity in Lung Cancer by Targeting PD-1/PD-L1 Signaling. Qian Jiang, Nan Zhang, +3 authors, Xin Li, Wei Hou, Xiao-Qing Zhao, Lei Liu. less Cancer Manag Res, 2021 Nov 20; 13. PMID: 34795530 Free PMC article.
Lipid-induced S-palmitoylation as a Vital Regulator of Cell Signaling and Disease Development. Mengyuan Qu, Xuan Zhou, Xiaotong Wang, Honggang Li. Int J Biol Sci, 2021 Nov 23; 17(15). PMID: 34803494 Free PMC article. Review.
Programmed Cell Death Ligand 1 Is Enriched in Mammary Stem Cells and Promotes Mammary Development and Regeneration. Ruirui Wang, Fujing Huang, +5 authors, Cheguo Cai. less Front Cell Dev Biol, 2021 Nov 23; 9. PMID: 34805179 Free PMC article.
Posttranslational Modifications in PD-L1 Turnover and Function: From Cradle to Grave. Xinfang Yu, Wei Li, Ken H Young, Yong Li. Biomedicines, 2021 Nov 28; 9(11). PMID: 34829931 Free PMC article. Review.
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. Ensong Guo, Rourou Xiao, +18 authors, Gang Chen. less J Exp Med, 2021 Nov 27; 219(1). PMID: 34825915 Free PMC article.
LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade. Yi Liu, Brian Debo, +3 authors, Yang Shi. less Nat Commun, 2021 Nov 26; 12(1). PMID: 34819502 Free PMC article.
Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer. Rajendra Kumar, Janet Mendonca, +22 authors, Sushant K Kachhap. less Cancer Res, 2021 Oct 15; 81(23). PMID: 34645612 Free PMC article.
TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment. Shusuke Kawashima, Takashi Inozume, +18 authors, Yosuke Togashi. less J Immunother Cancer, 2021 Nov 20; 9(11). PMID: 34795004 Free PMC article.
A Novel Strategy Conjugating PD-L1 Polypeptide With Doxorubicin Alleviates Chemotherapeutic Resistance and Enhances Immune Response in Colon Cancer. Maolin Wang, Xing-Sheng Shu, +8 authors, Ying Ying. less Front Oncol, 2021 Dec 04; 11. PMID: 34858817 Free PMC article.
Cross-Talk Between Tumor Cells Undergoing Epithelial to Mesenchymal Transition and Natural Killer Cells in Tumor Microenvironment in Colorectal Cancer. Ana Vuletić, Katarina Mirjačić Martinović, +3 authors, Milena Čavić. less Front Cell Dev Biol, 2021 Dec 04; 9. PMID: 34858978 Free PMC article. Review.
Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma. Fang Wen, Shuai Ruan, +6 authors, Peng Shu. less Front Med (Lausanne), 2021 Dec 04; 8. PMID: 34859010 Free PMC article.
Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications. Hannah-Lou Schilling, Gunther Glehr, +9 authors, Katharina Kronenberg. less Front Immunol, 2021 Dec 07; 12. PMID: 34868015 Free PMC article.
Identification of a Novel Ferroptosis-Related Gene Prediction Model for Clinical Prognosis and Immunotherapy of Colorectal Cancer. Ya-Bing Yang, Jia-Xin Zhou, +3 authors, Yun-Long Pan. less Dis Markers, 2021 Dec 07; 2021. PMID: 34868393 Free PMC article.

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