Review
. 2016 Mar; 8(328):328rv4.
doi: 10.1126/scitranslmed.aad7118.

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

Weiping Zou 1 Jedd D Wolchok 2 Lieping Chen 3 
Affiliations
  • PMID: 26936508
  •     176 References
  •     815 citations

Abstract

PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy and has elicited durable antitumor responses and long-term remissions in a subset of patients with a broad spectrum of cancers. How to improve, widen, and predict the clinical response to anti-PD therapy is a central theme in the field of cancer immunology and immunotherapy. Oncologic, immunologic, genetic, and biological studies focused on the human cancer microenvironment have yielded substantial insight into this issue. Here, we focus on tumor microenvironment and evaluate several potential therapeutic response markers including the PD-L1 and PD-1 expression pattern, genetic mutations within cancer cells and neoantigens, cancer epigenetics and effector T cell landscape, and microbiota. We further clarify the mechanisms of action of these markers and their roles in shaping, being shaped, and/or predicting therapeutic responses. We also discuss a variety of combinations with PD pathway blockade and their scientific rationales for cancer treatment.

Effector memory T cells, early metastasis, and survival in colorectal cancer.
Franck Pagès, Anne Berger, +13 authors, Jérôme Galon.
N Engl J Med, 2005 Dec 24; 353(25). PMID: 16371631
Highly Cited.
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
Roy S Herbst, Jean-Charles Soria, +19 authors, F Stephen Hodi.
Nature, 2014 Nov 28; 515(7528). PMID: 25428504    Free PMC article.
Highly Cited.
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.
Joe-Marc Chauvin, Ornella Pagliano, +8 authors, Hassane M Zarour.
J Clin Invest, 2015 Apr 14; 125(5). PMID: 25866972    Free PMC article.
Highly Cited.
Nivolumab plus ipilimumab in advanced melanoma.
Jedd D Wolchok, Harriet Kluger, +21 authors, Mario Sznol.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724867    Free PMC article.
Highly Cited.
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Lin Zhang, Jose R Conejo-Garcia, +9 authors, George Coukos.
N Engl J Med, 2003 Jan 17; 348(3). PMID: 12529460
Highly Cited.
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.
Mojgan Ahmadzadeh, Laura A Johnson, +4 authors, Steven A Rosenberg.
Blood, 2009 May 09; 114(8). PMID: 19423728    Free PMC article.
Highly Cited.
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.
Marie Vétizou, Jonathan M Pitt, +35 authors, Laurence Zitvogel.
Science, 2015 Nov 07; 350(6264). PMID: 26541610    Free PMC article.
Highly Cited.
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
Y Agata, A Kawasaki, +4 authors, T Honjo.
Int Immunol, 1996 May 01; 8(5). PMID: 8671665
Highly Cited.
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
Ramtin Rahbar, Albert Lin, +17 authors, Pamela S Ohashi.
Cancer Immunol Res, 2014 Dec 21; 3(2). PMID: 25527357
B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence.
Tai-Wei Sun, Qiang Gao, +9 authors, Jia Fan.
Cancer Immunol Immunother, 2012 Jun 26; 61(11). PMID: 22729558
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Junko Ozao-Choy, Ge Ma, +7 authors, Shu-Hsia Chen.
Cancer Res, 2009 Mar 12; 69(6). PMID: 19276342    Free PMC article.
Highly Cited.
Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.
Ilona Kryczek, Shuang Wei, +6 authors, Weiping Zou.
Cancer Res, 2007 Sep 19; 67(18). PMID: 17875732
Highly Cited.
Mutant MHC class II epitopes drive therapeutic immune responses to cancer.
Sebastian Kreiter, Mathias Vormehr, +12 authors, Ugur Sahin.
Nature, 2015 Apr 23; 520(7549). PMID: 25901682    Free PMC article.
Highly Cited.
Immune checkpoint blockade: a common denominator approach to cancer therapy.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804    Free PMC article.
Highly Cited. Review.
Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens.
Dallas B Flies, Tomoe Higuchi, Lieping Chen.
J Immunol, 2015 Apr 29; 194(11). PMID: 25917101    Free PMC article.
Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up.
R Houston Thompson, Susan M Kuntz, +11 authors, Eugene D Kwon.
Cancer Res, 2006 Apr 06; 66(7). PMID: 16585157
Highly Cited.
IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Andrew L Mellor, David H Munn.
Nat Rev Immunol, 2004 Oct 02; 4(10). PMID: 15459668
Highly Cited. Review.
Human TH17 cells are long-lived effector memory cells.
Ilona Kryczek, Ende Zhao, +7 authors, Weiping Zou.
Sci Transl Med, 2011 Oct 15; 3(104). PMID: 21998407    Free PMC article.
Highly Cited.
Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma.
Shari Pilon-Thomas, Amy Mackay, Nasreen Vohra, James J Mulé.
J Immunol, 2010 Mar 03; 184(7). PMID: 20194714    Free PMC article.
Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.
P Bansal-Pakala, A G Jember, M Croft.
Nat Med, 2001 Aug 02; 7(8). PMID: 11479622
Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer.
Junko Matsuzaki, Sacha Gnjatic, +9 authors, Kunle Odunsi.
Proc Natl Acad Sci U S A, 2010 Apr 14; 107(17). PMID: 20385810    Free PMC article.
Highly Cited.
Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer.
Scott N Gettinger, Leora Horn, +26 authors, Julie R Brahmer.
J Clin Oncol, 2015 Apr 22; 33(18). PMID: 25897158    Free PMC article.
Highly Cited.
Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis.
Haidong Dong, Scott E Strome, +6 authors, Lieping Chen.
J Clin Invest, 2003 Feb 06; 111(3). PMID: 12569162    Free PMC article.
Correlation of PD-L1 tumor expression and treatment outcomes in patients with renal cell carcinoma receiving sunitinib or pazopanib: results from COMPARZ, a randomized controlled trial.
Toni K Choueiri, David J Figueroa, +11 authors, Robert J Motzer.
Clin Cancer Res, 2014 Dec 30; 21(5). PMID: 25538263
Highly Cited.
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Julie R Brahmer, Charles G Drake, +17 authors, Suzanne L Topalian.
J Clin Oncol, 2010 Jun 03; 28(19). PMID: 20516446    Free PMC article.
Highly Cited.
Survival, Durable Response, and Long-Term Safety in Patients With Previously Treated Advanced Renal Cell Carcinoma Receiving Nivolumab.
David F McDermott, Charles G Drake, +18 authors, Michael B Atkins.
J Clin Oncol, 2015 Mar 25; 33(18). PMID: 25800770    Free PMC article.
Highly Cited.
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.
Stefani Spranger, Riyue Bao, Thomas F Gajewski.
Nature, 2015 May 15; 523(7559). PMID: 25970248
Highly Cited.
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Santiago Zelenay, Annemarthe G van der Veen, +9 authors, Caetano Reis e Sousa.
Cell, 2015 Sep 08; 162(6). PMID: 26343581    Free PMC article.
Highly Cited.
PD-1 blockade induces responses by inhibiting adaptive immune resistance.
Paul C Tumeh, Christina L Harview, +23 authors, Antoni Ribas.
Nature, 2014 Nov 28; 515(7528). PMID: 25428505    Free PMC article.
Highly Cited.
The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity.
SaeGwang Park, Zhujun Jiang, +11 authors, Yang-Xin Fu.
Cancer Cell, 2010 Aug 17; 18(2). PMID: 20708157    Free PMC article.
Highly Cited.
Combination cancer immunotherapy and new immunomodulatory targets.
Kathleen M Mahoney, Paul D Rennert, Gordon J Freeman.
Nat Rev Drug Discov, 2015 Aug 01; 14(8). PMID: 26228759
Highly Cited. Review.
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance.
Changping Wu, Yibei Zhu, +3 authors, Ning Xu.
Acta Histochem, 2006 Mar 15; 108(1). PMID: 16530813
Highly Cited.
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments.
Ilona Kryczek, Mousumi Banerjee, +11 authors, Weiping Zou.
Blood, 2009 May 28; 114(6). PMID: 19470694    Free PMC article.
Highly Cited.
Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model.
Lei Wang, Zohreh Amoozgar, +4 authors, Michael S Goldberg.
Cancer Immunol Res, 2015 Jun 10; 3(9). PMID: 26056145
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial.
Caroline Robert, Antoni Ribas, +22 authors, Adil Daud.
Lancet, 2014 Jul 19; 384(9948). PMID: 25034862
Highly Cited.
Science gone translational: the OX40 agonist story.
Andrew D Weinberg, Nicholas P Morris, +2 authors, Brendan D Curti.
Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017441    Free PMC article.
Review.
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.
Naiyer A Rizvi, Matthew D Hellmann, +21 authors, Timothy A Chan.
Science, 2015 Mar 15; 348(6230). PMID: 25765070    Free PMC article.
Highly Cited.
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127    Free PMC article.
Highly Cited.
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.
Eric Tran, Simon Turcotte, +10 authors, Steven A Rosenberg.
Science, 2014 May 09; 344(6184). PMID: 24812403    Free PMC article.
Highly Cited.
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine.
John Wrangle, Wei Wang, +25 authors, Stephen B Baylin.
Oncotarget, 2013 Oct 29; 4(11). PMID: 24162015    Free PMC article.
Highly Cited.
Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.
Huili Li, Katherine B Chiappinelli, +15 authors, Nita Ahuja.
Oncotarget, 2014 Mar 04; 5(3). PMID: 24583822    Free PMC article.
Highly Cited.
The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors.
Hazem Ghebeh, Shamayel Mohammed, +10 authors, Said Dermime.
Neoplasia, 2006 Apr 14; 8(3). PMID: 16611412    Free PMC article.
Highly Cited.
Accumulation of memory precursor CD8 T cells in regressing tumors following combination therapy with vaccine and anti-PD-1 antibody.
Lavakumar Karyampudi, Purushottam Lamichhane, +5 authors, Keith L Knutson.
Cancer Res, 2014 Apr 15; 74(11). PMID: 24728077    Free PMC article.
Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody.
Evan J Lipson, William H Sharfman, +10 authors, Suzanne L Topalian.
Clin Cancer Res, 2012 Nov 22; 19(2). PMID: 23169436    Free PMC article.
Highly Cited.
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
Manish J Butte, Mary E Keir, +2 authors, Gordon J Freeman.
Immunity, 2007 Jul 17; 27(1). PMID: 17629517    Free PMC article.
Highly Cited.
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J Curiel, George Coukos, +18 authors, Weiping Zou.
Nat Med, 2004 Aug 24; 10(9). PMID: 15322536
Highly Cited.
Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma.
Shuang Wei, Ilona Kryczek, +6 authors, Weiping Zou.
Cancer Res, 2005 Jun 17; 65(12). PMID: 15958543
Highly Cited.
Cyclophosphamide induces differentiation of Th17 cells in cancer patients.
Sophie Viaud, Caroline Flament, +9 authors, Laurence Zitvogel.
Cancer Res, 2010 Dec 15; 71(3). PMID: 21148486
A vaccine targeting mutant IDH1 induces antitumour immunity.
Theresa Schumacher, Lukas Bunse, +24 authors, Michael Platten.
Nature, 2014 Jul 22; 512(7514). PMID: 25043048
Highly Cited.
Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.
Shuang Wei, Andrew B Shreiner, +3 authors, Alfred E Chang.
Cancer Res, 2008 Jul 03; 68(13). PMID: 18593946    Free PMC article.
Immunosuppressive networks in the tumour environment and their therapeutic relevance.
Weiping Zou.
Nat Rev Cancer, 2005 Mar 19; 5(4). PMID: 15776005
Highly Cited. Review.
Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells.
Beatriz M Carreno, Vincent Magrini, +8 authors, Gerald P Linette.
Science, 2015 Apr 04; 348(6236). PMID: 25837513    Free PMC article.
Highly Cited.
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.
Michael A Postow, Jason Chesney, +18 authors, F Stephen Hodi.
N Engl J Med, 2015 Apr 22; 372(21). PMID: 25891304    Free PMC article.
Highly Cited.
Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage.
Ivan Perrot, Dominique Blanchard, +4 authors, Serge Lebecque.
J Immunol, 2007 Feb 22; 178(5). PMID: 17312119
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.
I Melero, W W Shuford, +5 authors, L Chen.
Nat Med, 1997 Jun 01; 3(6). PMID: 9176498
Highly Cited.
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.
Julien Fourcade, Zhaojun Sun, +6 authors, Hassane M Zarour.
J Exp Med, 2010 Sep 08; 207(10). PMID: 20819923    Free PMC article.
Highly Cited.
Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma.
Dirk Schadendorf, F Stephen Hodi, +7 authors, Jedd D Wolchok.
J Clin Oncol, 2015 Feb 11; 33(17). PMID: 25667295    Free PMC article.
Highly Cited.
Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial.
Philippe Armand, Arnon Nagler, +21 authors, Leo I Gordon.
J Clin Oncol, 2013 Oct 16; 31(33). PMID: 24127452    Free PMC article.
Highly Cited.
Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.
R Houston Thompson, Michael D Gillett, +12 authors, Eugene D Kwon.
Proc Natl Acad Sci U S A, 2004 Dec 01; 101(49). PMID: 15569934    Free PMC article.
Highly Cited.
Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs.
Bertrand Allard, Sandra Pommey, Mark J Smyth, John Stagg.
Clin Cancer Res, 2013 Aug 29; 19(20). PMID: 23983257
Highly Cited.
Inhibitory B7-family molecules in the tumour microenvironment.
Weiping Zou, Lieping Chen.
Nat Rev Immunol, 2008 May 27; 8(6). PMID: 18500231
Highly Cited. Review.
PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer.
Nisha Nagarsheth, Dongjun Peng, +15 authors, Weiping Zou.
Cancer Res, 2015 Nov 15; 76(2). PMID: 26567139    Free PMC article.
Highly Cited.
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.
Nicolas J Llosa, Michael Cruise, +15 authors, Franck Housseau.
Cancer Discov, 2014 Nov 02; 5(1). PMID: 25358689    Free PMC article.
Highly Cited.
Cancer immunotherapy: moving beyond current vaccines.
Steven A Rosenberg, James C Yang, Nicholas P Restifo.
Nat Med, 2004 Sep 02; 10(9). PMID: 15340416    Free PMC article.
Highly Cited.
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.
Pasquale Sansone, Gianluca Storci, +9 authors, Massimiliano Bonafè.
J Clin Invest, 2007 Dec 07; 117(12). PMID: 18060036    Free PMC article.
Highly Cited.
Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development.
Ilona Kryczek, Shuang Wei, +6 authors, Weiping Zou.
J Immunol, 2008 Oct 23; 181(9). PMID: 18941172
IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L.
Ilona Kryczek, Yanwei Lin, +13 authors, Weiping Zou.
Immunity, 2014 May 13; 40(5). PMID: 24816405    Free PMC article.
Highly Cited.
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.
Ende Zhao, Tomasz Maj, +22 authors, Weiping Zou.
Nat Immunol, 2015 Nov 03; 17(1). PMID: 26523864    Free PMC article.
Highly Cited.
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma.
Stephen M Ansell, Alexander M Lesokhin, +16 authors, Philippe Armand.
N Engl J Med, 2014 Dec 09; 372(4). PMID: 25482239    Free PMC article.
Highly Cited.
Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells.
W Zou, V Machelon, +13 authors, T J Curiel.
Nat Med, 2001 Dec 01; 7(12). PMID: 11726975
Highly Cited.
Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer.
Yuichiro Ohigashi, Masayuki Sho, +12 authors, Yoshiyuki Nakajima.
Clin Cancer Res, 2005 Apr 20; 11(8). PMID: 15837746
Highly Cited.
Decade in review-cancer immunotherapy: entering the mainstream of cancer treatment.
Steven A Rosenberg.
Nat Rev Clin Oncol, 2014 Oct 15; 11(11). PMID: 25311350    Free PMC article.
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma.
Andrew T Parsa, James S Waldron, +10 authors, Russell O Pieper.
Nat Med, 2006 Dec 13; 13(1). PMID: 17159987
Highly Cited.
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.
Tyler J Curiel, Shuang Wei, +19 authors, Weiping Zou.
Nat Med, 2003 Apr 22; 9(5). PMID: 12704383
Highly Cited.
Clinical importance of B7-H3 expression in human pancreatic cancer.
I Yamato, M Sho, +7 authors, Y Nakajima.
Br J Cancer, 2009 Oct 22; 101(10). PMID: 19844235    Free PMC article.
Multifaceted roles of PGE2 in inflammation and cancer.
Masako Nakanishi, Daniel W Rosenberg.
Semin Immunopathol, 2012 Sep 22; 35(2). PMID: 22996682    Free PMC article.
Highly Cited. Review.
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Michael T McCabe, Heidi M Ott, +19 authors, Caretha L Creasy.
Nature, 2012 Oct 12; 492(7427). PMID: 23051747
Highly Cited.
Improved survival with ipilimumab in patients with metastatic melanoma.
F Stephen Hodi, Steven J O'Day, +26 authors, Walter J Urba.
N Engl J Med, 2010 Jun 08; 363(8). PMID: 20525992    Free PMC article.
Highly Cited.
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Ayelet Sivan, Leticia Corrales, +9 authors, Thomas F Gajewski.
Science, 2015 Nov 07; 350(6264). PMID: 26541606    Free PMC article.
Highly Cited.
Molecular and genetic properties of tumors associated with local immune cytolytic activity.
Michael S Rooney, Sachet A Shukla, +2 authors, Nir Hacohen.
Cell, 2015 Jan 17; 160(1-2). PMID: 25594174    Free PMC article.
Highly Cited.
Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells.
Shanshan Wan, Ende Zhao, +6 authors, Theodore H Welling.
Gastroenterology, 2014 Sep 03; 147(6). PMID: 25181692    Free PMC article.
Highly Cited.
Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity.
Yongkui Li, Min Fang, +9 authors, Lin Wang.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057439    Free PMC article.
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.
Dongjun Peng, Ilona Kryczek, +15 authors, Weiping Zou.
Nature, 2015 Oct 28; 527(7577). PMID: 26503055    Free PMC article.
Highly Cited.
Epithelial cancer cell migration: a role for chemokine receptors?
C J Scotton, J L Wilson, +2 authors, F R Balkwill.
Cancer Res, 2001 Jun 30; 61(13). PMID: 11431324
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host.
Winston Timp, Andrew P Feinberg.
Nat Rev Cancer, 2013 Jun 14; 13(7). PMID: 23760024    Free PMC article.
Highly Cited. Review.
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.
Carsten Linnemann, Marit M van Buuren, +13 authors, Ton N M Schumacher.
Nat Med, 2014 Dec 23; 21(1). PMID: 25531942
Highly Cited.
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.
Christophe Ginestier, Suling Liu, +10 authors, Max S Wicha.
J Clin Invest, 2010 Jan 07; 120(2). PMID: 20051626    Free PMC article.
Highly Cited.
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.
Paul F Robbins, Yong-Chen Lu, +9 authors, Steven A Rosenberg.
Nat Med, 2013 May 07; 19(6). PMID: 23644516    Free PMC article.
Highly Cited.
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.
Noriho Iida, Amiran Dzutsev, +18 authors, Romina S Goldszmid.
Science, 2013 Nov 23; 342(6161). PMID: 24264989    Free PMC article.
Highly Cited.
Restoring function in exhausted CD8 T cells during chronic viral infection.
Daniel L Barber, E John Wherry, +5 authors, Rafi Ahmed.
Nature, 2005 Dec 31; 439(7077). PMID: 16382236
Highly Cited.
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ping-Chih Ho, Jessica Dauz Bihuniak, +15 authors, Susan M Kaech.
Cell, 2015 Sep 01; 162(6). PMID: 26321681    Free PMC article.
Highly Cited.
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma.
Omid Hamid, Caroline Robert, +23 authors, Antoni Ribas.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724846    Free PMC article.
Highly Cited.
Nivolumab in previously untreated melanoma without BRAF mutation.
Caroline Robert, Georgina V Long, +25 authors, Paolo A Ascierto.
N Engl J Med, 2014 Nov 18; 372(4). PMID: 25399552
Highly Cited.
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.
Robert H I Andtbacka, Howard L Kaufman, +26 authors, Robert S Coffin.
J Clin Oncol, 2015 May 28; 33(25). PMID: 26014293
Highly Cited.
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial.
Naiyer A Rizvi, Julien Mazières, +27 authors, Suresh S Ramalingam.
Lancet Oncol, 2015 Feb 24; 16(3). PMID: 25704439    Free PMC article.
Highly Cited.
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
Ilona Kryczek, Linhua Zou, +12 authors, Weiping Zou.
J Exp Med, 2006 Apr 12; 203(4). PMID: 16606666    Free PMC article.
Highly Cited.
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.
Dong-Ming Kuang, Qiyi Zhao, +4 authors, Limin Zheng.
J Exp Med, 2009 May 20; 206(6). PMID: 19451266    Free PMC article.
Highly Cited.
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen.
Andrew B Sharabi, Christopher J Nirschl, +5 authors, Charles G Drake.
Cancer Immunol Res, 2014 Dec 21; 3(4). PMID: 25527358    Free PMC article.
Highly Cited.
Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production.
Julia A Brown, David M Dorfman, +5 authors, Gordon J Freeman.
J Immunol, 2003 Jan 23; 170(3). PMID: 12538684
Highly Cited.
Innate and adaptive immune cells in the tumor microenvironment.
Thomas F Gajewski, Hans Schreiber, Yang-Xin Fu.
Nat Immunol, 2013 Sep 21; 14(10). PMID: 24048123    Free PMC article.
Highly Cited. Review.
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.
Liufu Deng, Hua Liang, +4 authors, Yang-Xin Fu.
J Clin Invest, 2014 Jan 03; 124(2). PMID: 24382348    Free PMC article.
Highly Cited.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.
Jérôme Galon, Anne Costes, +13 authors, Franck Pagès.
Science, 2006 Sep 30; 313(5795). PMID: 17008531
Highly Cited.
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).
Michal Marzec, Qian Zhang, +8 authors, Mariusz A Wasik.
Proc Natl Acad Sci U S A, 2008 Dec 18; 105(52). PMID: 19088198    Free PMC article.
Highly Cited.
Expression of tumour-specific antigens underlies cancer immunoediting.
Michel DuPage, Claire Mazumdar, +2 authors, Tyler Jacks.
Nature, 2012 Feb 10; 482(7385). PMID: 22318517    Free PMC article.
Highly Cited.
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Antonella Sistigu, Takahiro Yamazaki, +48 authors, Laurence Zitvogel.
Nat Med, 2014 Oct 27; 20(11). PMID: 25344738
Highly Cited.
Pembrolizumab versus Ipilimumab in Advanced Melanoma.
Caroline Robert, Jacob Schachter, +20 authors, KEYNOTE-006 investigators.
N Engl J Med, 2015 Apr 22; 372(26). PMID: 25891173
Highly Cited.
Regulatory T cells, tumour immunity and immunotherapy.
Weiping Zou.
Nat Rev Immunol, 2006 Mar 25; 6(4). PMID: 16557261
Highly Cited. Review.
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
G J Freeman, A J Long, +16 authors, T Honjo.
J Exp Med, 2000 Oct 04; 192(7). PMID: 11015443    Free PMC article.
Highly Cited.
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
Lauren L C Marotta, Vanessa Almendro, +25 authors, Kornelia Polyak.
J Clin Invest, 2011 Jun 03; 121(7). PMID: 21633165    Free PMC article.
Highly Cited.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski.
Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400    Free PMC article.
Highly Cited.
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Cheryl L Day, Daniel E Kaufmann, +19 authors, Bruce D Walker.
Nature, 2006 Aug 22; 443(7109). PMID: 16921384
Highly Cited.
Correlation between NK function and response to trastuzumab in metastatic breast cancer patients.
Alessandra Beano, Elena Signorino, +7 authors, Lina Matera.
J Transl Med, 2008 May 20; 6. PMID: 18485193    Free PMC article.
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.
Roy L Maute, Sydney R Gordon, +10 authors, Aaron M Ring.
Proc Natl Acad Sci U S A, 2015 Nov 26; 112(47). PMID: 26604307    Free PMC article.
Highly Cited.
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab.
Suzanne L Topalian, Mario Sznol, +18 authors, F Stephen Hodi.
J Clin Oncol, 2014 Mar 05; 32(10). PMID: 24590637    Free PMC article.
Highly Cited.
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.
Alena Gros, Paul F Robbins, +13 authors, Steven A Rosenberg.
J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667641    Free PMC article.
Highly Cited.
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.
Jeffrey S Weber, Sandra P D'Angelo, +25 authors, James Larkin.
Lancet Oncol, 2015 Mar 22; 16(4). PMID: 25795410
Highly Cited.
Effects of tumor irradiation on host T-regulatory cells and systemic immunity in the context of adoptive T-cell therapy in mice.
Shuang Wei, Martin U Egenti, +2 authors, Alfred E Chang.
J Immunother, 2013 Feb 05; 36(2). PMID: 23377667    Free PMC article.
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.
Chih-Hao Chang, Jing Qiu, +11 authors, Erika L Pearce.
Cell, 2015 Sep 01; 162(6). PMID: 26321679    Free PMC article.
Highly Cited.
Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial.
Jason R Westin, Fuliang Chu, +19 authors, Sattva S Neelapu.
Lancet Oncol, 2013 Dec 18; 15(1). PMID: 24332512    Free PMC article.
Highly Cited.
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.
Christine Feig, James O Jones, +12 authors, Douglas T Fearon.
Proc Natl Acad Sci U S A, 2013 Nov 28; 110(50). PMID: 24277834    Free PMC article.
Highly Cited.
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.
Takeshi Azuma, Sheng Yao, +3 authors, Lieping Chen.
Blood, 2008 Jan 29; 111(7). PMID: 18223165    Free PMC article.
Highly Cited.
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.
Robert J Johnston, Laetitia Comps-Agrar, +9 authors, Jane L Grogan.
Cancer Cell, 2014 Dec 04; 26(6). PMID: 25465800
Highly Cited.
Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade.
Simon J Dovedi, Amy L Adlard, +11 authors, Tim M Illidge.
Cancer Res, 2014 Oct 03; 74(19). PMID: 25274032
Highly Cited.
Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia.
John C Byrd, Thomas J Kipps, +8 authors, Susan O'Brien.
Leuk Lymphoma, 2012 Apr 06; 53(11). PMID: 22475052    Free PMC article.
Signatures of mutational processes in human cancer.
Ludmil B Alexandrov, Serena Nik-Zainal, +72 authors, Michael R Stratton.
Nature, 2013 Aug 16; 500(7463). PMID: 23945592    Free PMC article.
Highly Cited.
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.
Jeffrey S Weber, Ragini Reiney Kudchadkar, +11 authors, Y Ann Chen.
J Clin Oncol, 2013 Oct 23; 31(34). PMID: 24145345    Free PMC article.
Highly Cited.
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Li Wang, Rotem Rubinstein, +10 authors, Randolph J Noelle.
J Exp Med, 2011 Mar 09; 208(3). PMID: 21383057    Free PMC article.
Highly Cited.
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer.
Thomas Powles, Joseph Paul Eder, +12 authors, Nicholas J Vogelzang.
Nature, 2014 Nov 28; 515(7528). PMID: 25428503
Highly Cited.
Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.
Joal D Beane, Gary Lee, +20 authors, Steven A Feldman.
Mol Ther, 2015 May 06; 23(8). PMID: 25939491    Free PMC article.
A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma.
Gregory L Beatty, Drew A Torigian, +8 authors, Peter J O'Dwyer.
Clin Cancer Res, 2013 Aug 29; 19(22). PMID: 23983255    Free PMC article.
Highly Cited.
T cells and costimulation in cancer.
Tomasz Maj, Shuang Wei, Ted Welling, Weiping Zou.
Cancer J, 2013 Nov 26; 19(6). PMID: 24270346
Review.
Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer.
Jaikumar Duraiswamy, Gordon J Freeman, George Coukos.
Cancer Res, 2013 Aug 27; 73(23). PMID: 23975756    Free PMC article.
Highly Cited.
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
Jing Tan, Xiaojing Yang, +7 authors, Qiang Yu.
Genes Dev, 2007 Apr 18; 21(9). PMID: 17437993    Free PMC article.
Highly Cited.
Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth.
Sonja Kleffel, Christian Posch, +19 authors, Tobias Schatton.
Cell, 2015 Sep 12; 162(6). PMID: 26359984    Free PMC article.
Highly Cited.
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Christina Twyman-Saint Victor, Andrew J Rech, +22 authors, Andy J Minn.
Nature, 2015 Mar 11; 520(7547). PMID: 25754329    Free PMC article.
Highly Cited.
NK cell-based immunotherapy for malignant diseases.
Min Cheng, Yongyan Chen, +2 authors, Zhigang Tian.
Cell Mol Immunol, 2013 Apr 23; 10(3). PMID: 23604045    Free PMC article.
Highly Cited. Review.
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
H Dong, G Zhu, K Tamada, L Chen.
Nat Med, 1999 Dec 02; 5(12). PMID: 10581077
Highly Cited.
Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer.
Anna Woloszynska-Read, Paulette Mhawech-Fauceglia, +2 authors, Adam R Karpf.
Clin Cancer Res, 2008 Jun 04; 14(11). PMID: 18519754    Free PMC article.
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.
Tracy X Cui, Ilona Kryczek, +14 authors, Weiping Zou.
Immunity, 2013 Sep 10; 39(3). PMID: 24012420    Free PMC article.
Highly Cited.
Decoding cell death signals in inflammation and immunity.
Laurence Zitvogel, Oliver Kepp, Guido Kroemer.
Cell, 2010 Mar 23; 140(6). PMID: 20303871
Highly Cited.
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.
Julie Brahmer, Karen L Reckamp, +22 authors, David R Spigel.
N Engl J Med, 2015 Jun 02; 373(2). PMID: 26028407    Free PMC article.
Highly Cited.
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.
Matthew M Gubin, Xiuli Zhang, +24 authors, Robert D Schreiber.
Nature, 2014 Nov 28; 515(7528). PMID: 25428507    Free PMC article.
Highly Cited.
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting.
Hirokazu Matsushita, Matthew D Vesely, +16 authors, Robert D Schreiber.
Nature, 2012 Feb 10; 482(7385). PMID: 22318521    Free PMC article.
Highly Cited.
Characterization of PD-L1 Expression and Associated T-cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites.
Harriet M Kluger, Christopher R Zito, +6 authors, Lucia B Jilaveanu.
Clin Cancer Res, 2015 Mar 20; 21(13). PMID: 25788491    Free PMC article.
Highly Cited.
Pembrolizumab for the treatment of non-small-cell lung cancer.
Edward B Garon, Naiyer A Rizvi, +25 authors, KEYNOTE-001 Investigators.
N Engl J Med, 2015 Apr 22; 372(21). PMID: 25891174
Highly Cited.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.
Youjin Lee, Sogyong L Auh, +9 authors, Yang-Xin Fu.
Blood, 2009 Apr 08; 114(3). PMID: 19349616    Free PMC article.
Highly Cited.
Programmed death ligand-1 expression in non-small cell lung cancer.
Vamsidhar Velcheti, Kurt A Schalper, +7 authors, David L Rimm.
Lab Invest, 2013 Nov 13; 94(1). PMID: 24217091    Free PMC article.
Highly Cited.
Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity.
Dallas B Flies, Xue Han, +4 authors, Lieping Chen.
J Clin Invest, 2014 Apr 20; 124(5). PMID: 24743150    Free PMC article.
Highly Cited.
Neoantigens in cancer immunotherapy.
Ton N Schumacher, Robert D Schreiber.
Science, 2015 Apr 04; 348(6230). PMID: 25838375
Highly Cited. Review.
Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.
Hang Li, Ke Wu, +8 authors, Weiping Zou.
Hepatology, 2012 Apr 17; 56(4). PMID: 22505239
Highly Cited.
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.
Janis M Taube, Alison Klein, +7 authors, Robert A Anders.
Clin Cancer Res, 2014 Apr 10; 20(19). PMID: 24714771    Free PMC article.
Highly Cited.
Regulatory T-cell compartmentalization and trafficking.
Shuang Wei, Ilona Kryczek, Weiping Zou.
Blood, 2006 Mar 16; 108(2). PMID: 16537800    Free PMC article.
Review.
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.
Shabnam Shalapour, Joan Font-Burgada, +13 authors, Michael Karin.
Nature, 2015 Apr 30; 521(7550). PMID: 25924065    Free PMC article.
Highly Cited.
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Junzo Hamanishi, Masaki Mandai, +9 authors, Shingo Fujii.
Proc Natl Acad Sci U S A, 2007 Mar 16; 104(9). PMID: 17360651    Free PMC article.
Highly Cited.
Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs.
Raymond M Wong, Ron R Scotland, +4 authors, Jeffrey S Weber.
Int Immunol, 2007 Sep 28; 19(10). PMID: 17898045
B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells.
Liqun Luo, Andrei I Chapoval, +9 authors, Lieping Chen.
J Immunol, 2004 Oct 21; 173(9). PMID: 15494491
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Janis M Taube, Robert A Anders, +8 authors, Lieping Chen.
Sci Transl Med, 2012 Mar 31; 4(127). PMID: 22461641    Free PMC article.
Highly Cited.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
Highly Cited.
Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-cc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
Michinori Ogura, Takashi Ishida, +16 authors, Ryuzo Ueda.
J Clin Oncol, 2014 Mar 13; 32(11). PMID: 24616310
Highly Cited.
IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer.
Ilona Kryczek, Ke Wu, +11 authors, Weiping Zou.
J Immunol, 2011 Mar 02; 186(7). PMID: 21357259
Highly Cited.
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Haidong Dong, Scott E Strome, +10 authors, Lieping Chen.
Nat Med, 2002 Jul 02; 8(8). PMID: 12091876
Highly Cited.
PD-L1 expression in triple-negative breast cancer.
Elizabeth A Mittendorf, Anne V Philips, +14 authors, Gheath Alatrash.
Cancer Immunol Res, 2014 Apr 26; 2(4). PMID: 24764583    Free PMC article.
Highly Cited.
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.
Felix Klug, Hridayesh Prakash, +15 authors, Philipp Beckhove.
Cancer Cell, 2013 Nov 12; 24(5). PMID: 24209604
Highly Cited.
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.
Sophie Viaud, Fabiana Saccheri, +30 authors, Laurence Zitvogel.
Science, 2013 Nov 23; 342(6161). PMID: 24264990    Free PMC article.
Highly Cited.
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity.
Kaori Sakuishi, Lionel Apetoh, +3 authors, Ana C Anderson.
J Exp Med, 2010 Sep 08; 207(10). PMID: 20819927    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance.
Jang-June Park, Ryusuke Omiya, +11 authors, Koji Tamada.
Blood, 2010 May 18; 116(8). PMID: 20472828    Free PMC article.
Highly Cited.
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.
Yanping Xiao, Sanhong Yu, +9 authors, Gordon J Freeman.
J Exp Med, 2014 Apr 23; 211(5). PMID: 24752301    Free PMC article.
Highly Cited.
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
Julie R Brahmer, Scott S Tykodi, +23 authors, Jon M Wigginton.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658128    Free PMC article.
Highly Cited.
CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers.
Ilona Kryczek, Andrzej Lange, +13 authors, Weiping Zou.
Cancer Res, 2005 Feb 08; 65(2). PMID: 15695388
Highly Cited.
Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.
Lieping Chen, Xue Han.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325035    Free PMC article.
Highly Cited. Review.
Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions.
Ke Wu, Ilona Kryczek, +2 authors, Theodore H Welling.
Cancer Res, 2009 Oct 15; 69(20). PMID: 19826049    Free PMC article.
Highly Cited.
Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells.
Michael R Nazareth, Lori Broderick, +3 authors, Richard B Bankert.
J Immunol, 2007 Apr 20; 178(9). PMID: 17442937
Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer.
Weimin Wang, Ilona Kryczek, +18 authors, Weiping Zou.
Cell, 2016 May 03; 165(5). PMID: 27133165    Free PMC article.
Highly Cited.
PD-1 Shapes B Cells as Evildoers in the Tumor Microenvironment.
Zhenhua Ren, Hua Peng, Yang-Xin Fu.
Cancer Discov, 2016 May 04; 6(5). PMID: 27138562    Free PMC article.
Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps.
Gregory L Beatty, Mark O'Hara.
Pharmacol Ther, 2016 Jul 05; 166. PMID: 27373504    Free PMC article.
Review.
Combinatorial immunotherapeutic approaches to restore the function of anergic tumor-reactive cytotoxic CD8+ T cells.
William L Redmond, Stefanie N Linch.
Hum Vaccin Immunother, 2016 Jul 28; 12(10). PMID: 27459422    Free PMC article.
CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas.
Katherine A Murphy, Thomas S Griffith.
Cancers (Basel), 2016 Jul 30; 8(8). PMID: 27472363    Free PMC article.
Review.
Classification of Advanced Human Cancers Based on Tumor Immunity in the MicroEnvironment (TIME) for Cancer Immunotherapy.
Yu Zhang, Lieping Chen.
JAMA Oncol, 2016 Aug 05; 2(11). PMID: 27490017    Free PMC article.
Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us?
Michiel van der Vlist, Jurgen Kuball, Timothy R D Radstake, Linde Meyaard.
Nat Rev Rheumatol, 2016 Aug 20; 12(10). PMID: 27539666
Review.
Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody.
Chao Wang, Wujin Sun, +2 authors, Zhen Gu.
Adv Mater, 2016 Oct 21; 28(40). PMID: 27558441    Free PMC article.
Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes.
Elizabeth Shurell, Arun S Singh, +9 authors, Fritz C Eilber.
Oncotarget, 2016 Sep 03; 7(39). PMID: 27588404    Free PMC article.
BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression.
Hengrui Zhu, Fee Bengsch, +8 authors, Rugang Zhang.
Cell Rep, 2016 Sep 15; 16(11). PMID: 27626654    Free PMC article.
Highly Cited.
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
Nissim Hay.
Nat Rev Cancer, 2016 Sep 17; 16(10). PMID: 27634447    Free PMC article.
Highly Cited. Review.
Emerging roles of p53 and other tumour-suppressor genes in immune regulation.
César Muñoz-Fontela, Anna Mandinova, Stuart A Aaronson, Sam W Lee.
Nat Rev Immunol, 2016 Nov 01; 16(12). PMID: 27667712    Free PMC article.
Highly Cited. Review.
Local delivery of checkpoints antibodies.
Chao Wang, Yanqi Ye, Zhen Gu.
Hum Vaccin Immunother, 2016 Sep 27; 13(1). PMID: 27668759    Free PMC article.
Mouse models in oncoimmunology.
Laurence Zitvogel, Jonathan M Pitt, +2 authors, Guido Kroemer.
Nat Rev Cancer, 2016 Nov 04; 16(12). PMID: 27687979
Highly Cited. Review.
Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity.
Peng Tan, Lian He, Gang Han, Yubin Zhou.
Trends Biotechnol, 2016 Oct 04; 35(3). PMID: 27692897    Free PMC article.
Review.
SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin.
Giustina Ferone, Ji-Ying Song, +6 authors, Anton Berns.
Cancer Cell, 2016 Oct 12; 30(4). PMID: 27728803    Free PMC article.
Highly Cited.
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.
Kelly D Moynihan, Cary F Opel, +19 authors, Darrell J Irvine.
Nat Med, 2016 Nov 01; 22(12). PMID: 27775706    Free PMC article.
Highly Cited.
Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies.
Shuguang Tan, Danqing Chen, +9 authors, George F Gao.
Protein Cell, 2016 Nov 07; 7(12). PMID: 27815822    Free PMC article.
Review.
Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8+ T Cells co-expressing PD-1 and LAG-3 inhibitory receptors.
Ameet K Mishra, Tanya Kadoishi, +4 authors, Jing H Wang.
Oncotarget, 2016 Nov 12; 7(49). PMID: 27835902    Free PMC article.
Basis for molecular diagnostics and immunotherapy for esophageal cancer.
Joe Abdo, Devendra K Agrawal, Sumeet K Mittal.
Expert Rev Anticancer Ther, 2016 Nov 15; 17(1). PMID: 27838937    Free PMC article.
Review.
Molecular Profiling of Thymoma and Thymic Carcinoma: Genetic Differences and Potential Novel Therapeutic Targets.
Franz Enkner, Bettina Pichlhöfer, +9 authors, Leonhard Müllauer.
Pathol Oncol Res, 2016 Nov 16; 23(3). PMID: 27844328    Free PMC article.
Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma.
Fang-Zhu Ouyang, Rui-Qi Wu, +7 authors, Dong-Ming Kuang.
Nat Commun, 2016 Nov 18; 7. PMID: 27853178    Free PMC article.
The Impact of Chemotherapy, Radiation and Epigenetic Modifiers in Cancer Cell Expression of Immune Inhibitory and Stimulatory Molecules and Anti-Tumor Efficacy.
Jessica Ann Chacon, Keith Schutsky, Daniel J Powell.
Vaccines (Basel), 2016 Nov 18; 4(4). PMID: 27854240    Free PMC article.
Review.
Deubiquitination and Stabilization of PD-L1 by CSN5.
Seung-Oe Lim, Chia-Wei Li, +19 authors, Mien-Chie Hung.
Cancer Cell, 2016 Nov 22; 30(6). PMID: 27866850    Free PMC article.
Highly Cited.
The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients.
Minghui Zhang, Yuandi Dong, +5 authors, Qingyuan Zhang.
Sci Rep, 2016 Nov 29; 6. PMID: 27892511    Free PMC article.
Recurrent pleural effusions and cardiac tamponade as possible manifestations of pseudoprogression associated with nivolumab therapy- a report of two cases.
Bhaskar C Kolla, Manish R Patel.
J Immunother Cancer, 2016 Nov 30; 4. PMID: 27895919    Free PMC article.
Higher programmed cell death 1 ligand 1 (PD-L1) mRNA level in clear cell renal cell carcinomas is associated with a favorable outcome due to the active immune responses in tumor tissues.
Xiang-Hui Ning, Yan-Qing Gong, +8 authors, Kan Gong.
Oncotarget, 2016 Dec 08; 8(2). PMID: 27926518    Free PMC article.
Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists.
Gregory L Beatty, Yan Li, Kristen B Long.
Expert Rev Anticancer Ther, 2016 Dec 09; 17(2). PMID: 27927088    Free PMC article.
Review.
Extracellular Vesicles: Unique Intercellular Delivery Vehicles.
Sybren L N Maas, Xandra O Breakefield, Alissa M Weaver.
Trends Cell Biol, 2016 Dec 17; 27(3). PMID: 27979573    Free PMC article.
Highly Cited. Review.
PD-L1, PD-L2 and PD-1 expression in metastatic melanoma: Correlation with tumor-infiltrating immune cells and clinical outcome.
Joseph M Obeid, Gulsun Erdag, +5 authors, Craig L Slingluff.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999753    Free PMC article.
Designer vaccine nanodiscs for personalized cancer immunotherapy.
Rui Kuai, Lukasz J Ochyl, +2 authors, James J Moon.
Nat Mater, 2016 Dec 27; 16(4). PMID: 28024156    Free PMC article.
Highly Cited.
A New VISTA on combination therapy for negative checkpoint regulator blockade.
Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J Noelle.
J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031817    Free PMC article.
Review.
Combination therapy with L-arginine and α-PD-L1 antibody boosts immune response against osteosarcoma in immunocompetent mice.
Xiaojun He, Haiqing Lin, Li Yuan, Binghao Li.
Cancer Biol Ther, 2017 Jan 04; 18(2). PMID: 28045576    Free PMC article.
Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma.
Kai-Chao Feng, Ye-Lei Guo, +6 authors, Wei-Dong Han.
J Hematol Oncol, 2017 Jan 07; 10(1). PMID: 28057014    Free PMC article.
Highly Cited.
Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer.
Emeka K Enwere, Elizabeth N Kornaga, +8 authors, Corinne M Doll.
Mod Pathol, 2017 Jan 07; 30(4). PMID: 28059093
Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication.
Ainhoa Arina, Theodore Karrison, +3 authors, Hans Schreiber.
Cancer Immunol Res, 2017 Jan 13; 5(2). PMID: 28077434    Free PMC article.
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.
Kenji Chamoto, Partha S Chowdhury, +4 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2017 Jan 18; 114(5). PMID: 28096382    Free PMC article.
Highly Cited.
SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.
Tom L Stephen, Kyle K Payne, +11 authors, Jose R Conejo-Garcia.
Immunity, 2017 Jan 19; 46(1). PMID: 28099864    Free PMC article.
Highly Cited.
Elements of cancer immunity and the cancer-immune set point.
Daniel S Chen, Ira Mellman.
Nature, 2017 Jan 20; 541(7637). PMID: 28102259
Highly Cited. Review.
PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective.
Jun Wang, Ruirong Yuan, +3 authors, Zihai Li.
J Hematol Oncol, 2017 Jan 27; 10(1). PMID: 28122590    Free PMC article.
Highly Cited. Review.
Immune contexture and histological response after neoadjuvant chemotherapy predict clinical outcome of lung cancer patients.
Romain Remark, Audrey Lupo, +8 authors, Diane Damotte.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123901    Free PMC article.
cGAS is essential for the antitumor effect of immune checkpoint blockade.
Hua Wang, Shuiqing Hu, +4 authors, Zhijian J Chen.
Proc Natl Acad Sci U S A, 2017 Feb 01; 114(7). PMID: 28137885    Free PMC article.
Highly Cited.
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
Takeru Asano, Yusuke Meguri, +17 authors, Ken-Ichi Matsuoka.
Blood, 2017 Feb 06; 129(15). PMID: 28151427    Free PMC article.
Highly Cited.
An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.
Shuguang Tan, Hao Zhang, +13 authors, Jinghua Yan.
Nat Commun, 2017 Feb 07; 8. PMID: 28165004    Free PMC article.
Highly Cited.
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.
Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas.
Cell, 2017 Feb 12; 168(4). PMID: 28187290    Free PMC article.
Highly Cited. Review.
Tumor-infiltrating lymphocyte composition, organization and PD-1/ PD-L1 expression are linked in breast cancer.
Laurence Buisseret, Soizic Garaud, +14 authors, Karen Willard-Gallo.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197375    Free PMC article.
Highly Cited.
A human programmed death-ligand 1-expressing mouse tumor model for evaluating the therapeutic efficacy of anti-human PD-L1 antibodies.
Anfei Huang, Di Peng, +8 authors, F Xiao-Feng Qin.
Sci Rep, 2017 Feb 17; 7. PMID: 28202921    Free PMC article.
Macrophages Polarized by Expression of ToxoGRA15II Inhibit Growth of Hepatic Carcinoma.
Yuanling Li, Faustina Poppoe, +6 authors, Jilong Shen.
Front Immunol, 2017 Mar 01; 8. PMID: 28243242    Free PMC article.
Inflammatory cytokines compromise programmed cell death-1 (PD-1)-mediated T cell suppression in inflammatory arthritis through up-regulation of soluble PD-1.
D Bommarito, C Hall, L S Taams, V M Corrigall.
Clin Exp Immunol, 2017 Mar 01; 188(3). PMID: 28245522    Free PMC article.
Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.
Fei Zhang, Hudie Wei, +8 authors, Aiwu Zhou.
Cell Discov, 2017 Mar 11; 3. PMID: 28280600    Free PMC article.
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.
Vikram R Juneja, Kathleen A McGuire, +5 authors, Arlene H Sharpe.
J Exp Med, 2017 Mar 18; 214(4). PMID: 28302645    Free PMC article.
Highly Cited.
Immune checkpoint dysfunction in large and medium vessel vasculitis.
Ryu Watanabe, Hui Zhang, +2 authors, Cornelia M Weyand.
Am J Physiol Heart Circ Physiol, 2017 Mar 21; 312(5). PMID: 28314758    Free PMC article.
Review.
PD-L1 expression in pancreatic ductal adenocarcinoma is a poor prognostic factor in patients with high CD8+ tumor-infiltrating lymphocytes: highly sensitive detection using phosphor-integrated dot staining.
So Yamaki, Hiroaki Yanagimoto, +2 authors, Masanori Kon.
Int J Clin Oncol, 2017 Mar 21; 22(4). PMID: 28314962    Free PMC article.
Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition.
Florine A Eggink, Inge C Van Gool, +11 authors, Tjalling Bosse.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344870    Free PMC article.
CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy.
Nan Chen, Aurore Morello, Zachary Tano, Prasad S Adusumilli.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344886    Free PMC article.
STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer.
Rui Li, Fang Fang, +13 authors, Weihua Xiao.
Sci Rep, 2017 Mar 30; 7. PMID: 28350008    Free PMC article.
The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.
Yichuan Xiao, Qiang Zou, +13 authors, Shao-Cong Sun.
J Exp Med, 2017 Mar 31; 214(5). PMID: 28356390    Free PMC article.
PDL1 expression is a poor-prognosis factor in soft-tissue sarcomas.
François Bertucci, Pascal Finetti, +7 authors, Emilie Mamessier.
Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405501    Free PMC article.
High expression of B7-H6 in human glioma tissues promotes tumor progression.
Tianwei Jiang, Wei Wu, +6 authors, Chunhua Hang.
Oncotarget, 2017 Apr 19; 8(23). PMID: 28415577    Free PMC article.
New transcriptional-based insights into the pathogenesis of desmoplastic small round cell tumors (DSRCTs).
Tiziana Negri, Silvia Brich, +7 authors, Silvana Pilotti.
Oncotarget, 2017 Apr 19; 8(20). PMID: 28415643    Free PMC article.
Expression of PD-L1 and prognosis in breast cancer: a meta-analysis.
Minghui Zhang, Houbin Sun, +4 authors, Qingyuan Zhang.
Oncotarget, 2017 Apr 22; 8(19). PMID: 28430626    Free PMC article.
Highly Cited.
A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway.
Lei Zhao, Cheng Li, +6 authors, Chunlin Ge.
Onco Targets Ther, 2017 Apr 27; 10. PMID: 28442920    Free PMC article.
Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model.
Kyoung-Jin Kim, Ji-Hye Kim, +3 authors, Jinsil Seong.
Oncotarget, 2017 May 04; 8(25). PMID: 28465485    Free PMC article.
Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
Udupi A Ramagopal, Weifeng Liu, +10 authors, Steven C Almo.
Proc Natl Acad Sci U S A, 2017 May 10; 114(21). PMID: 28484017    Free PMC article.
Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells.
Yuying Liu, Xiaoyu Liang, +18 authors, Bo Huang.
Nat Commun, 2017 May 11; 8. PMID: 28488695    Free PMC article.
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy.
Jan Willem Kleinovink, Koen A Marijt, +3 authors, Marieke F Fransen.
Oncoimmunology, 2017 May 17; 6(4). PMID: 28507803    Free PMC article.
Highly Cited.
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.
Sydney R Gordon, Roy L Maute, +10 authors, Irving L Weissman.
Nature, 2017 May 18; 545(7655). PMID: 28514441    Free PMC article.
Highly Cited.
Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans.
Kenji Tsuchihashi, Hitoshi Kusaba, +19 authors, Eishi Baba.
Mol Clin Oncol, 2017 May 19; 6(5). PMID: 28515919    Free PMC article.
Showing the Way: Oncolytic Adenoviruses as Chaperones of Immunostimulatory Adjuncts.
Jing Li Huang, Christopher J LaRocca, Masato Yamamoto.
Biomedicines, 2017 May 26; 4(3). PMID: 28536390    Free PMC article.
Review.
Delivering safer immunotherapies for cancer.
Lauren Milling, Yuan Zhang, Darrell J Irvine.
Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888    Free PMC article.
Highly Cited. Review.
Quantitative Mass Spectrometry Analysis of PD-L1 Protein Expression, N-glycosylation and Expression Stoichiometry with PD-1 and PD-L2 in Human Melanoma.
Carlos A Morales-Betanzos, Hyoungjoo Lee, +4 authors, Daniel C Liebler.
Mol Cell Proteomics, 2017 May 27; 16(10). PMID: 28546465    Free PMC article.
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy.
Nisha Nagarsheth, Max S Wicha, Weiping Zou.
Nat Rev Immunol, 2017 May 31; 17(9). PMID: 28555670    Free PMC article.
Highly Cited. Review.
Bisdemethoxycurcumin in combination with α-PD-L1 antibody boosts immune response against bladder cancer.
Yiqun Shao, Wenjing Zhu, +4 authors, Zhong Wang.
Onco Targets Ther, 2017 Jun 06; 10. PMID: 28579805    Free PMC article.
IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours.
Hyungseok Seo, Insu Jeon, +15 authors, Chang-Yuil Kang.
Nat Commun, 2017 Jun 07; 8. PMID: 28585539    Free PMC article.
Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients.
M F Sanmamed, J L Perez-Gracia, +17 authors, I Melero.
Ann Oncol, 2017 Jun 09; 28(8). PMID: 28595336    Free PMC article.
Highly Cited.
Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity.
Ryu Watanabe, Tsuyoshi Shirai, +9 authors, Cornelia M Weyand.
J Clin Invest, 2017 Jun 13; 127(7). PMID: 28604383    Free PMC article.
New insights into the role of EMT in tumor immune escape.
Stéphane Terry, Pierre Savagner, +4 authors, Salem Chouaib.
Mol Oncol, 2017 Jun 15; 11(7). PMID: 28614624    Free PMC article.
Highly Cited. Review.
PD-L1 protein expression in non-small cell lung cancer based on different immunohistochemical antibodies.
Minghui Zhang, Di Feng, +3 authors, Qingyuan Zhang.
J Thorac Dis, 2017 Jun 16; 9(5). PMID: 28616312    Free PMC article.
β-Catenin in desmoid-type fibromatosis: deep insights into the role of T41A and S45F mutations on protein structure and gene expression.
Chiara Colombo, Antonino Belfiore, +13 authors, Federica Perrone.
Mol Oncol, 2017 Jun 20; 11(11). PMID: 28627792    Free PMC article.
PD-1 and cancer: molecular mechanisms and polymorphisms.
Arash Salmaninejad, Vahid Khoramshahi, +6 authors, Sayed Mostafa Hosseini.
Immunogenetics, 2017 Jun 24; 70(2). PMID: 28642997
Review.
Immunological effects of hypomethylating agents.
Katherine E Lindblad, Meghali Goswami, Christopher S Hourigan, Karolyn A Oetjen.
Expert Rev Hematol, 2017 Jun 24; 10(8). PMID: 28644756    Free PMC article.
Review.
Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages.
Liang Cheng, Jiatao Liu, +10 authors, Guoping Sun.
Int J Biol Sci, 2017 Jun 29; 13(6). PMID: 28655998    Free PMC article.
Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours.
Mira M Shenouda, Amy Gillgrass, +10 authors, Ali A Ashkar.
Breast Cancer Res, 2017 Jul 03; 19(1). PMID: 28668076    Free PMC article.
Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?
Neil Dunavin, Ajoy Dias, Meizhang Li, Joseph McGuirk.
Biomedicines, 2017 Jul 04; 5(3). PMID: 28671556    Free PMC article.
Review.
Endogenous Heat-Shock Protein Induction with or Without Radiofrequency Ablation or Cryoablation in Patients with Stage IV Melanoma.
Evidio Domingo-Musibay, James M Heun, +5 authors, Svetomir N Markovic.
Oncologist, 2017 Jul 07; 22(9). PMID: 28679643    Free PMC article.
Chemotherapeutic tumor microparticles combining low-dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway.
Yanling Sun, Zu'an Zheng, +12 authors, Bo Huang.
Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680743    Free PMC article.
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy.
TaChung Yu, Fangfang Guo, +12 authors, Jing-Yuan Fang.
Cell, 2017 Jul 29; 170(3). PMID: 28753429    Free PMC article.
Highly Cited.
New PD-L1 inhibitors in non-small cell lung cancer - impact of atezolizumab.
Nagashree Seetharamu, Isabel R Preeshagul, Kevin M Sullivan.
Lung Cancer (Auckl), 2017 Aug 02; 8. PMID: 28761384    Free PMC article.
Review.
Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells.
Peihong Dai, Weiyi Wang, +7 authors, Liang Deng.
Sci Immunol, 2017 Aug 02; 2(11). PMID: 28763795    Free PMC article.
PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy.
Junyu Long, Jianzhen Lin, +7 authors, Haitao Zhao.
J Hematol Oncol, 2017 Aug 05; 10(1). PMID: 28774337    Free PMC article.
Review.
Targeting Immune System Alterations in Hodgkin Lymphoma.
Natalie S Grover, Barbara Savoldo.
Curr Hematol Malig Rep, 2017 Aug 07; 12(4). PMID: 28780614    Free PMC article.
Review.
Pembrolizumab reactivates pulmonary granulomatosis.
Majdi Al-Dliw, Mohammed Megri, +3 authors, Yousef Shweihat.
Respir Med Case Rep, 2017 Aug 11; 22. PMID: 28794963    Free PMC article.
89Zr-labeled nivolumab for imaging of T-cell infiltration in a humanized murine model of lung cancer.
Christopher G England, Dawei Jiang, +7 authors, Weibo Cai.
Eur J Nucl Med Mol Imaging, 2017 Aug 20; 45(1). PMID: 28821924    Free PMC article.
T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics.
Z Wu, N V Cheung.
Pharmacol Ther, 2017 Aug 24; 182. PMID: 28834699    Free PMC article.
Review.
PD-L1 expression in lung cancer and its correlation with driver mutations: a meta-analysis.
Minghui Zhang, Guoliang Li, +5 authors, Yan Wang.
Sci Rep, 2017 Sep 02; 7(1). PMID: 28860576    Free PMC article.
Highly Cited.
Prognostic significance of PD-L1 expression and 18F-FDG PET/CT in surgical pulmonary squamous cell carcinoma.
Minghui Zhang, Dalong Wang, +5 authors, Qiangyuan Zhang.
Oncotarget, 2017 Sep 09; 8(31). PMID: 28881674    Free PMC article.
Analysis of the whole transcriptome from gingivo-buccal squamous cell carcinoma reveals deregulated immune landscape and suggests targets for immunotherapy.
Richa Singh, Navonil De Sarkar, +6 authors, Bidyut Roy.
PLoS One, 2017 Sep 09; 12(9). PMID: 28886030    Free PMC article.
Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.
Samarchith P Kurup, Nyamekye Obeng-Adjei, +5 authors, John T Harty.
Nat Med, 2017 Sep 12; 23(10). PMID: 28892065    Free PMC article.
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.
Ying Zhang, Raj Kurupati, +17 authors, Hildegund C J Ertl.
Cancer Cell, 2017 Sep 13; 32(3). PMID: 28898698    Free PMC article.
Highly Cited.
Genomic Analysis of Tumor Microenvironment Immune Types across 14 Solid Cancer Types: Immunotherapeutic Implications.
Yu-Pei Chen, Yu Zhang, +9 authors, Jun Ma.
Theranostics, 2017 Sep 16; 7(14). PMID: 28912897    Free PMC article.
Highly Cited.
[Novel Immuno-oncology Therapy: Current Status of Clinical Research and Prospect of Application].
Shijia Zhang, Shengxiang Ren.
Zhongguo Fei Ai Za Zhi, 2017 Sep 25; 20(9). PMID: 28935020    Free PMC article.
Review.
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.
Jingying Zhou, Man Liu, +17 authors, Alfred Sze-Lok Cheng.
Gut, 2017 Sep 25; 67(5). PMID: 28939663    Free PMC article.
B cells in the pathophysiology of myasthenia gravis.
John S Yi, Jeffrey T Guptill, +2 authors, Kevin C O'Connor.
Muscle Nerve, 2017 Sep 25; 57(2). PMID: 28940642    Free PMC article.
Review.
Nanomaterials for cancer immunotherapy.
Wantong Song, Sara N Musetti, Leaf Huang.
Biomaterials, 2017 Sep 30; 148. PMID: 28961532    Free PMC article.
Review.
Lambda phage-based vaccine induces antitumor immunity in hepatocellular carcinoma.
Yoshifumi Iwagami, Sarah Casulli, +10 authors, Jack R Wands.
Heliyon, 2017 Oct 04; 3(9). PMID: 28971150    Free PMC article.
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer.
Scott Gettinger, Jungmin Choi, +23 authors, Katerina Politi.
Cancer Discov, 2017 Oct 14; 7(12). PMID: 29025772    Free PMC article.
Highly Cited.
Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma.
Hyein Ahn, Jeong Mi Yang, +4 authors, Jin Ho Paik.
Oncotarget, 2017 Oct 17; 8(39). PMID: 29029502    Free PMC article.
Expression of PD-1 and PD-L1 in poorly differentiated neuroendocrine carcinomas of the digestive system: a potential target for anti-PD-1/PD-L1 therapy.
Jordan A Roberts, Raul S Gonzalez, +2 authors, Chanjuan Shi.
Hum Pathol, 2017 Oct 19; 70. PMID: 29037958    Free PMC article.
Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer.
Yohei Masugi, Reiko Nishihara, +22 authors, Shuji Ogino.
Cancer Immunol Res, 2017 Oct 19; 5(11). PMID: 29038297    Free PMC article.
Identification and Validation of a PD-L1 Binding Peptide for Determination of PDL1 Expression in Tumors.
Charles Caldwell, Cory E Johnson, +3 authors, Raghuraman Kannan.
Sci Rep, 2017 Oct 24; 7(1). PMID: 29057919    Free PMC article.
Cardiovascular Immunotherapy and the Role of Imaging.
Eva Zupančič, Zahi A Fayad, Willem J M Mulder.
Arterioscler Thromb Vasc Biol, 2017 Oct 27; 37(11). PMID: 29070539    Free PMC article.
Review.
Resistance to checkpoint blockade therapy through inactivation of antigen presentation.
Moshe Sade-Feldman, Yunxin J Jiao, +28 authors, Nir Hacohen.
Nat Commun, 2017 Oct 27; 8(1). PMID: 29070816    Free PMC article.
Highly Cited.
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.
Tomasz Maj, Wei Wang, +11 authors, Weiping Zou.
Nat Immunol, 2017 Oct 31; 18(12). PMID: 29083399    Free PMC article.
Highly Cited.
Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway.
Ming Jing Shen, Li Jun Xu, +5 authors, Yuhchyau Chen.
Oncotarget, 2017 Nov 09; 8(46). PMID: 29113321    Free PMC article.
Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade.
Haoran Zha, Xiao Han, +5 authors, Bo Zhu.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123963    Free PMC article.
Immune Analysis of Radium-223 in Patients With Metastatic Prostate Cancer.
Joseph W Kim, Min Sun Shin, +2 authors, Daniel P Petrylak.
Clin Genitourin Cancer, 2017 Nov 16; 16(2). PMID: 29137877    Free PMC article.
Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions.
Jin Lee, Rui Liao, +7 authors, Gen-Sheng Feng.
Cell Rep, 2017 Nov 16; 21(7). PMID: 29141219    Free PMC article.
Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy.
Yuchen Fan, Rui Kuai, +3 authors, James J Moon.
Nano Lett, 2017 Nov 17; 17(12). PMID: 29144754    Free PMC article.
Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.
Houjun Xia, Wei Wang, +12 authors, Weiping Zou.
Sci Immunol, 2017 Nov 19; 2(17). PMID: 29150439    Free PMC article.
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Jinfang Zhang, Xia Bu, +15 authors, Wenyi Wei.
Nature, 2017 Nov 22; 553(7686). PMID: 29160310    Free PMC article.
Highly Cited.
B7-H1 Influences the Accumulation of Virus-Specific Tissue Resident Memory T Cells in the Central Nervous System.
Kevin D Pavelko, Michael P Bell, Susan M Harrington, Haidong Dong.
Front Immunol, 2017 Nov 25; 8. PMID: 29170671    Free PMC article.
Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma.
Wojciech K Panek, J Robert Kane, +4 authors, Maciej S Lesniak.
Oncotarget, 2017 Nov 29; 8(51). PMID: 29179527    Free PMC article.
Review.
Immunotherapy in metastatic urothelial carcinoma: focus on immune checkpoint inhibition.
Arlene Siefker-Radtke, Brendan Curti.
Nat Rev Urol, 2017 Dec 06; 15(2). PMID: 29205200
Review.
Phenotype and tissue distribution of CD28H+ immune cell subsets.
Joel Crespo, Linda Vatan, +3 authors, Weiping Zou.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209568    Free PMC article.
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy.
Robert J Torphy, Richard D Schulick, Yuwen Zhu.
Int J Mol Sci, 2017 Dec 07; 18(12). PMID: 29211042    Free PMC article.
Review.
Significant benefit of Nivolumab treating PD-L1 positive metastatic pulmonary carcinosarcoma: a case report and literature review.
Zhe Zhang, Yishan Chen, +9 authors, Mingfang Zhao.
Oncotarget, 2017 Dec 10; 8(56). PMID: 29221220    Free PMC article.
Co-relation of overall survival with peripheral blood-based inflammatory biomarkers in advanced stage non-small cell lung cancer treated with anti-programmed cell death-1 therapy: results from a single institutional database.
Abdul Rafeh Naqash, Chipman Robert Geoffrey Stroud, +7 authors, Paul R Walker.
Acta Oncol, 2017 Dec 16; 57(6). PMID: 29241410    Free PMC article.
Expression and clinical value of programmed cell death-ligand 1 (PD-L1) in diffuse large B cell lymphoma: a retrospective study.
Li-Yang Hu, Xiao-Lu Xu, +7 authors, Qing-Qing Cai.
Chin J Cancer, 2017 Dec 17; 36(1). PMID: 29246182    Free PMC article.
PD-L1 Promotes Self-Renewal and Tumorigenicity of Malignant Melanoma Initiating Cells.
Fang Zheng, Jianzhong Dang, +3 authors, Fanjun Cheng.
Biomed Res Int, 2017 Dec 19; 2017. PMID: 29250533    Free PMC article.
Preclinical and clinical development of neoantigen vaccines.
L Li, S P Goedegebuure, W E Gillanders.
Ann Oncol, 2017 Dec 19; 28(suppl_12). PMID: 29253113    Free PMC article.
Review.
Tumor-associated macrophages-additional effectors at anti-PD-1/PD-L1 therapy?
Kenichi Suda.
J Thorac Dis, 2017 Dec 23; 9(11). PMID: 29268470    Free PMC article.
Recent Successes and Future Directions in Immunotherapy of Cutaneous Melanoma.
Hassan Sadozai, Thomas Gruber, Robert Emil Hunger, Mirjam Schenk.
Front Immunol, 2017 Dec 26; 8. PMID: 29276510    Free PMC article.
Review.
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models.
Katherine E Lewis, Mark J Selby, +11 authors, Stacey R Dillon.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296539    Free PMC article.
PD-1 related transcriptome profile and clinical outcome in diffuse gliomas.
Shuai Liu, Zheng Wang, +5 authors, Tao Jiang.
Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308304    Free PMC article.
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.
Marco Bezzi, Nina Seitzer, +11 authors, Pier Paolo Pandolfi.
Nat Med, 2018 Jan 09; 24(2). PMID: 29309058
Highly Cited.
Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy.
Misako Matsumoto, Yohei Takeda, Megumi Tatematsu, Tsukasa Seya.
Front Immunol, 2018 Jan 10; 8. PMID: 29312355    Free PMC article.
Review.
Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells.
S Alivernini, B Tolusso, +3 authors, I B McInnes.
Clin Exp Immunol, 2018 Jan 10; 193(1). PMID: 29315512    Free PMC article.
Review.
Cell Membrane Bioconjugation and Membrane-Derived Nanomaterials for Immunotherapy.
Peter Y Li, Zhiyuan Fan, Hao Cheng.
Bioconjug Chem, 2018 Jan 13; 29(3). PMID: 29323870    Free PMC article.
Review.
PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.
Haidong Tang, Yong Liang, +18 authors, Yang-Xin Fu.
J Clin Invest, 2018 Jan 18; 128(2). PMID: 29337303    Free PMC article.
Highly Cited.
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.
Heng Lin, Shuang Wei, +16 authors, Weiping Zou.
J Clin Invest, 2018 Jan 18; 128(2). PMID: 29337305    Free PMC article.
Highly Cited.
High number of PD-1 positive intratumoural lymphocytes predicts survival benefit of cytokine-induced killer cells for hepatocellular carcinoma patients.
Boyang Chang, Lujun Shen, +5 authors, Peihong Wu.
Liver Int, 2018 Jan 23; 38(8). PMID: 29356308    Free PMC article.
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations.
Jun Gong, Alexander Chehrazi-Raffle, Srikanth Reddi, Ravi Salgia.
J Immunother Cancer, 2018 Jan 24; 6(1). PMID: 29357948    Free PMC article.
Highly Cited. Review.
PD-L1 and Emerging Biomarkers in Immune Checkpoint Blockade Therapy.
Tricia R Cottrell, Janis M Taube.
Cancer J, 2018 Jan 24; 24(1). PMID: 29360727    Free PMC article.
Review.
Mechanisms of Resistance to PD-1 and PD-L1 Blockade.
Theodore S Nowicki, Siwen Hu-Lieskovan, Antoni Ribas.
Cancer J, 2018 Jan 24; 24(1). PMID: 29360728    Free PMC article.
Highly Cited. Review.
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
Tamas Fulop, Anis Larbi, +5 authors, Claudio Franceschi.
Front Immunol, 2018 Jan 30; 8. PMID: 29375577    Free PMC article.
Highly Cited. Review.
Inhibition of the checkpoint protein PD-1 by the therapeutic antibody pembrolizumab outlined by quantum chemistry.
Ana Beatriz M L A Tavares, José X Lima Neto, Umberto L Fulco, Eudenilson L Albuquerque.
Sci Rep, 2018 Feb 01; 8(1). PMID: 29382901    Free PMC article.
Colorectal cancer prevention: Immune modulation taking the stage.
Rochelle Fletcher, Yi-Jun Wang, +3 authors, Lin Zhang.
Biochim Biophys Acta Rev Cancer, 2018 Feb 03; 1869(2). PMID: 29391185    Free PMC article.
Review.
PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse.
Bingxin Zheng, Tingting Ren, +5 authors, Wei Guo.
J Hematol Oncol, 2018 Feb 08; 11(1). PMID: 29409495    Free PMC article.
Highly Cited.
HLA class I loss and PD-L1 expression in lung cancer: impact on T-cell infiltration and immune escape.
Francisco Perea, Abel Sánchez-Palencia, +9 authors, Natalia Aptsiauri.
Oncotarget, 2018 Feb 10; 9(3). PMID: 29423109    Free PMC article.
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype.
Degao Chen, Jing Xie, +14 authors, Bo Huang.
Nat Commun, 2018 Mar 02; 9(1). PMID: 29491374    Free PMC article.
Highly Cited.
B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction.
Ling Chen, Takeshi Azuma, +3 authors, Lieping Chen.
Proc Natl Acad Sci U S A, 2018 Mar 07; 115(12). PMID: 29507197    Free PMC article.
Cytokine-induced killer cells as a feasible adoptive immunotherapy for the treatment of lung cancer.
Dan Chen, Huanhuan Sha, +10 authors, Jifeng Feng.
Cell Death Dis, 2018 Mar 08; 9(3). PMID: 29511158    Free PMC article.
The MYC oncogene is a global regulator of the immune response.
Stephanie C Casey, Virginie Baylot, Dean W Felsher.
Blood, 2018 Mar 09; 131(18). PMID: 29514782    Free PMC article.
Review.
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis.
Constantinos Roufas, Dimitrios Chasiotis, +3 authors, Apostolos Zaravinos.
Front Oncol, 2018 Mar 09; 8. PMID: 29515971    Free PMC article.
Molecular Mechanisms and Emerging Therapeutic Targets of Triple-Negative Breast Cancer Metastasis.
Christiana Neophytou, Panagiotis Boutsikos, Panagiotis Papageorgis.
Front Oncol, 2018 Mar 10; 8. PMID: 29520340    Free PMC article.
Highly Cited. Review.
Engineering Vaccines to Reprogram Immunity against Head and Neck Cancer.
Y S Tan, K Sansanaphongpricha, +3 authors, Y L Lei.
J Dent Res, 2018 Mar 14; 97(6). PMID: 29533731    Free PMC article.
Review.
Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.
Emilia Vendelova, Diyaaeldin Ashour, +4 authors, Manfred B Lutz.
Front Immunol, 2018 Mar 16; 9. PMID: 29541071    Free PMC article.
Review.
Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy.
Naoto Nishii, Hidetake Tachinami, +8 authors, Miyuki Azuma.
Oncotarget, 2018 Mar 24; 9(17). PMID: 29568358    Free PMC article.
Prognostic value of PD-L1 in esophageal squamous cell carcinoma: a meta-analysis.
Wei Guo, Pan Wang, +6 authors, Jie He.
Oncotarget, 2018 Mar 24; 9(17). PMID: 29568405    Free PMC article.
Mechanistic insights into cancer immunity and immunotherapy.
Weiping Zou.
Cell Mol Immunol, 2018 Mar 25; 15(5). PMID: 29572549    Free PMC article.
EP4 as a Therapeutic Target for Aggressive Human Breast Cancer.
Mousumi Majumder, Pinki Nandi, +2 authors, Peeyush K Lala.
Int J Mol Sci, 2018 Mar 30; 19(4). PMID: 29596308    Free PMC article.
Review.
Oncogenic Signaling Pathways and Pathway-Based Therapeutic Biomarkers in Lymphoid Malignancies.
Ruifang Sun, Jinfen Wang, Ken H Young.
Crit Rev Oncog, 2017 Jan 01; 22(5-6). PMID: 29604930    Free PMC article.
Review.
Low-dose decitabine enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by re-modulating the tumor microenvironment.
Ganjun Yu, Yanfeng Wu, +4 authors, Tao Wan.
Cell Mol Immunol, 2018 Apr 07; 16(4). PMID: 29622799    Free PMC article.
Immunotherapy Plus Cryotherapy: Potential Augmented Abscopal Effect for Advanced Cancers.
Joe Abdo, David L Cornell, Sumeet K Mittal, Devendra K Agrawal.
Front Oncol, 2018 Apr 13; 8. PMID: 29644213    Free PMC article.
Review.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations.
Judith A Seidel, Atsushi Otsuka, Kenji Kabashima.
Front Oncol, 2018 Apr 13; 8. PMID: 29644214    Free PMC article.
Highly Cited. Review.
Increased vessel perfusion predicts the efficacy of immune checkpoint blockade.
Xichen Zheng, Zhaoxu Fang, +17 authors, Yuhui Huang.
J Clin Invest, 2018 Apr 18; 128(5). PMID: 29664018    Free PMC article.
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Tingting Wang, Dangge Wang, +6 authors, Yaping Li.
Nat Commun, 2018 Apr 20; 9(1). PMID: 29670088    Free PMC article.
Elimination of established tumors with nanodisc-based combination chemoimmunotherapy.
Rui Kuai, Wenmin Yuan, +5 authors, James J Moon.
Sci Adv, 2018 Apr 21; 4(4). PMID: 29675465    Free PMC article.
Highly Cited.
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions.
Tong Zhang, Xiaomin Song, +20 authors, Kang Li.
Cancer Immunol Immunother, 2018 Apr 25; 67(7). PMID: 29687231    Free PMC article.
Integrative Pharmacology: Advancing Development of Effective Immunotherapies.
Mohammad Tabrizi, Daping Zhang, Vaishnavi Ganti, Glareh Azadi.
AAPS J, 2018 Apr 29; 20(4). PMID: 29704129
Review.
Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.
Shaojia Wang, Jiajia Li, +7 authors, Xiaohua Wu.
Oncogene, 2018 May 01; 37(30). PMID: 29706653
Noninvasive PET Imaging of T cells.
Weijun Wei, Dawei Jiang, +2 authors, Weibo Cai.
Trends Cancer, 2018 May 02; 4(5). PMID: 29709260    Free PMC article.
Review.
The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update.
Semir Vranic, Farhan Sachal Cyprian, Saghir Akhtar, Ala-Eddin Al Moustafa.
Front Oncol, 2018 May 03; 8. PMID: 29719817    Free PMC article.
Review.
Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells.
Sonja Lieber, Silke Reinartz, +8 authors, Magdalena Huber.
Oncoimmunology, 2018 May 04; 7(5). PMID: 29721385    Free PMC article.
M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine.
Karin M Knudson, Kristin C Hicks, +3 authors, Sofia R Gameiro.
Oncoimmunology, 2018 May 04; 7(5). PMID: 29721396    Free PMC article.
Highly Cited.
B7-H1 Expression Is Required for Human Endometrial Regenerative Cells in the Prevention of Transplant Vasculopathy in Mice.
Kui Ye, Xu Lan, +5 authors, Hao Wang.
Stem Cells Int, 2018 May 08; 2018. PMID: 29731774    Free PMC article.
YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting.
Federica Lo Sardo, Sabrina Strano, Giovanni Blandino.
Cancers (Basel), 2018 May 08; 10(5). PMID: 29734788    Free PMC article.
Review.
Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?
Fei Tang, Pan Zheng.
Cell Biosci, 2018 May 11; 8. PMID: 29744030    Free PMC article.
T Follicular Regulatory Cells and Antibody Responses in Transplantation.
Elizabeth F Wallin.
Transplantation, 2018 May 15; 102(10). PMID: 29757907    Free PMC article.
Review.
STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.
Jung-Mao Hsu, Weiya Xia, +14 authors, Mien-Chie Hung.
Nat Commun, 2018 May 17; 9(1). PMID: 29765039    Free PMC article.
Highly Cited.
Defining and Understanding Adaptive Resistance in Cancer Immunotherapy.
Tae Kon Kim, Roy S Herbst, Lieping Chen.
Trends Immunol, 2018 May 29; 39(8). PMID: 29802087    Free PMC article.
Highly Cited. Review.
Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer.
Wei Li, Takashi Tanikawa, +15 authors, Weiping Zou.
Cell Metab, 2018 May 29; 28(1). PMID: 29805099    Free PMC article.
Highly Cited.
Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens.
Mengjia Song, Xinfeng Chen, Liping Wang, Yi Zhang.
Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861603    Free PMC article.
Multiplex bead-based measurement of humoral immune responses against tumor-associated antigens in stage II melanoma patients of the EORTC18961 trial.
Judith Michels, Natalia Becker, +11 authors, Inka Zörnig.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872552    Free PMC article.
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap.
Wantong Song, Limei Shen, +7 authors, Leaf Huang.
Nat Commun, 2018 Jun 10; 9(1). PMID: 29884866    Free PMC article.
Highly Cited.
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.
Daniela S Thommen, Viktor H Koelzer, +16 authors, Alfred Zippelius.
Nat Med, 2018 Jun 13; 24(7). PMID: 29892065    Free PMC article.
Highly Cited.
PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study.
Giulia Bertolini, Luca Bergamaschi, +11 authors, Patrizia Gasparini.
BMC Cancer, 2018 Jun 15; 18(1). PMID: 29898687    Free PMC article.
Dynamic change of PD-L1 expression on circulating tumor cells in advanced solid tumor patients undergoing PD-1 blockade therapy.
Chunyan Yue, Yubo Jiang, +9 authors, Jianming Xu.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900038    Free PMC article.
Highly Cited.
CD133-directed CAR T cells for advanced metastasis malignancies: A phase I trial.
Yao Wang, Meixia Chen, +11 authors, Weidong Han.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900044    Free PMC article.
Highly Cited.
Tumor Regression and Cure Depends on Sustained Th1 Responses.
Min Dai, Ingegerd Hellstrom, +2 authors, Karl Erik Hellstrom.
J Immunother, 2018 Jun 19; 41(8). PMID: 29912725    Free PMC article.
Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma.
Chao-Qun Liu, Jing Xu, +7 authors, Limin Zheng.
Br J Cancer, 2018 Jun 21; 119(1). PMID: 29921949    Free PMC article.
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.
Wanqiang Sheng, Martin W LaFleur, +13 authors, Yang Shi.
Cell, 2018 Jun 26; 174(3). PMID: 29937226    Free PMC article.
Highly Cited.
Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth.
Yi Yang, Chia-Wei Li, +8 authors, Mien-Chie Hung.
Cell Res, 2018 Jul 01; 28(8). PMID: 29959401    Free PMC article.
Highly Cited.
Harmonization of PD-L1 testing in oncology: a Canadian pathology perspective.
D N Ionescu, M R Downes, A Christofides, M S Tsao.
Curr Oncol, 2018 Jul 03; 25(3). PMID: 29962847    Free PMC article.
Review.
Active Role of the Necrotic Zone in Desensitization of Hypoxic Macrophages and Regulation of CSC-Fate: A hypothesis.
Maryam Mehrabi, Fatemeh Amini, Shima Mehrabi.
Front Oncol, 2018 Jul 11; 8. PMID: 29988496    Free PMC article.
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells.
Yunlong Zhao, Devin L Harrison, +3 authors, Enfu Hui.
Cell Rep, 2018 Jul 12; 24(2). PMID: 29996099    Free PMC article.
Safety and efficacy of durvalumab (MEDI4736) in various solid tumors.
Hui Yang, Kai Shen, +3 authors, Xuelei Ma.
Drug Des Devel Ther, 2018 Jul 18; 12. PMID: 30013326    Free PMC article.
Interferon gamma in cancer immunotherapy.
Ling Ni, Jian Lu.
Cancer Med, 2018 Jul 25; 7(9). PMID: 30039553    Free PMC article.
Highly Cited. Review.
Beneficial and Paradoxical Roles of Anti-Oxidative Nutritional Support for Non-Alcoholic Fatty Liver Disease.
Daisuke Uchida, Akinobu Takaki, Takuya Adachi, Hiroyuki Okada.
Nutrients, 2018 Aug 01; 10(8). PMID: 30060482    Free PMC article.
Review.
Activation of phagocytosis by immune checkpoint blockade.
Chia-Wei Li, Yun-Ju Lai, Jennifer L Hsu, Mien-Chie Hung.
Front Med, 2018 Aug 01; 12(4). PMID: 30062558    Free PMC article.
Review.
Comparison of Microbiota in Patients Treated by Surgery or Chemotherapy by 16S rRNA Sequencing Reveals Potential Biomarkers for Colorectal Cancer Therapy.
Xingming Deng, Zhuofei Li, +3 authors, Guoqing Lyu.
Front Microbiol, 2018 Aug 02; 9. PMID: 30065719    Free PMC article.
Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling.
Justin Lucas, Tze-Chen Hsieh, +2 authors, Joseph M Wu.
Int J Oncol, 2018 Aug 02; 53(4). PMID: 30066852    Free PMC article.
Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody.
Kyoko Yamaguchi, Koji Mishima, +12 authors, Eishi Baba.
Cancer Sci, 2018 Aug 02; 109(10). PMID: 30066977    Free PMC article.
White paper on microbial anti-cancer therapy and prevention.
Neil S Forbes, Robert S Coffin, +20 authors, Grant McFadden.
J Immunother Cancer, 2018 Aug 08; 6(1). PMID: 30081947    Free PMC article.
Review.
Checkpoint blockade-based immunotherapy in the context of tumor microenvironment: Opportunities and challenges.
Jingjing Duan, Yu Wang, Shunchang Jiao.
Cancer Med, 2018 Aug 09; 7(9). PMID: 30088347    Free PMC article.
Review.
CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas.
Xiudong Guan, Chuanbao Zhang, +3 authors, Wang Jia.
EBioMedicine, 2018 Aug 23; 35. PMID: 30131308    Free PMC article.
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance.
Young-Jun Park, Da-Sol Kuen, Yeonseok Chung.
Exp Mol Med, 2018 Aug 24; 50(8). PMID: 30135516    Free PMC article.
Highly Cited. Review.
Topoisomerase I inhibitor, irinotecan, depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression, resulting in a supra-additive antitumor effect when combined with anti-PD-L1 antibodies.
Toshiki Iwai, Masamichi Sugimoto, +3 authors, Kaname Yamamoto.
Oncotarget, 2018 Aug 25; 9(59). PMID: 30140379    Free PMC article.
Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1.
Yu-Tzu Tai, Shih-Feng Cho, Kenneth C Anderson.
Front Immunol, 2018 Aug 28; 9. PMID: 30147691    Free PMC article.
Review.
Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.
Ying Wang, Lijing Su, +17 authors, Bruce Beutler.
Proc Natl Acad Sci U S A, 2018 Aug 29; 115(37). PMID: 30150374    Free PMC article.
Chemotherapeutic Treatments Increase PD-L1 Expression in Esophageal Squamous Cell Carcinoma through EGFR/ERK Activation.
Hoi Yan Ng, Jian Li, +7 authors, Maria Li Lung.
Transl Oncol, 2018 Sep 03; 11(6). PMID: 30172884    Free PMC article.
Tumor-infiltrating T cells in epithelial ovarian cancer: predictors of prognosis and biological basis of immunotherapy.
Weimin Wang, Weiping Zou, J Rebecca Liu.
Gynecol Oncol, 2018 Sep 24; 151(1). PMID: 30243508    Free PMC article.
Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer.
Yihao Mao, Qingyang Feng, +10 authors, Jianmin Xu.
Cancer Manag Res, 2018 Oct 03; 10. PMID: 30271205    Free PMC article.
Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy.
Jinfang Zhang, Fabin Dang, Junming Ren, Wenyi Wei.
Trends Biochem Sci, 2018 Oct 06; 43(12). PMID: 30287140    Free PMC article.
Review.
Combination with SGT-53 overcomes tumor resistance to a checkpoint inhibitor.
Sang-Soo Kim, Joe B Harford, +2 authors, Esther H Chang.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288347    Free PMC article.
Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences.
Xinyu Yan, Shouyue Zhang, +3 authors, Heng Xu.
Front Pharmacol, 2018 Oct 09; 9. PMID: 30294272    Free PMC article.
Review.
Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1).
Marcin Kowanetz, Wei Zou, +27 authors, Priti S Hegde.
Proc Natl Acad Sci U S A, 2018 Oct 10; 115(43). PMID: 30297397    Free PMC article.
Highly Cited.
Biosynthetic energy cost for amino acids decreases in cancer evolution.
Hong Zhang, Yirong Wang, +5 authors, Jian Lu.
Nat Commun, 2018 Oct 10; 9(1). PMID: 30297703    Free PMC article.
The Protein Expression of PDL1 Is Highly Correlated with Those of eIF2α and ATF4 in Lung Cancer.
Liang-Che Chang, Tzu-Ping Chen, Wei-Ke Kuo, Chung-Ching Hua.
Dis Markers, 2018 Oct 12; 2018. PMID: 30305853    Free PMC article.
Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity.
Gianluca D'Agostino, Valentina Cecchinato, Mariagrazia Uguccioni.
Front Immunol, 2018 Oct 16; 9. PMID: 30319638    Free PMC article.
Review.
Programmed death ligand 1 expression in human intrahepatic cholangiocarcinoma and its association with prognosis and CD8+ T-cell immune responses.
Ying Zhu, Xiang-Yu Wang, +6 authors, Xin Yang.
Cancer Manag Res, 2018 Oct 17; 10. PMID: 30323667    Free PMC article.
Multimodal detection of PD-L1: reasonable biomarkers for immune checkpoint inhibitor.
Qiao Yang, Zihan Xu, +3 authors, Jianguo Sun.
Am J Cancer Res, 2018 Oct 17; 8(9). PMID: 30323963    Free PMC article.
Review.
Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity.
Farideh Ordikhani, Mayuko Uehara, +12 authors, Reza Abdi.
JCI Insight, 2018 Oct 20; 3(20). PMID: 30333312    Free PMC article.
Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.
Lu Xu, Yang Zhang, +13 authors, Han Liu.
J Exp Clin Cancer Res, 2018 Oct 31; 37(1). PMID: 30373602    Free PMC article.
Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types.
Kristin C Hicks, Massimo Fantini, +10 authors, Sofia R Gameiro.
Oncoimmunology, 2018 Nov 01; 7(11). PMID: 30377559    Free PMC article.
Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance.
Yong Liang, Haidong Tang, +12 authors, Yang-Xin Fu.
Nat Commun, 2018 Nov 06; 9(1). PMID: 30389912    Free PMC article.
An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.
John D Klement, Amy V Paschall, +7 authors, Kebin Liu.
J Clin Invest, 2018 Nov 06; 128(12). PMID: 30395540    Free PMC article.
A novel ternary heterostructure with dramatic SERS activity for evaluation of PD-L1 expression at the single-cell level.
Enduo Feng, Tingting Zheng, +2 authors, Yang Tian.
Sci Adv, 2018 Nov 09; 4(11). PMID: 30406203    Free PMC article.
Prognostic significance of programmed cell death ligand 1 expression in patients with ovarian carcinoma: A systematic review and meta-analysis.
Li-Jun Huang, Xiao-Feng Deng, +3 authors, Qi-Zhi Diao.
Medicine (Baltimore), 2018 Nov 10; 97(43). PMID: 30412078    Free PMC article.
Systematic Review.
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy.
Kebin Liu, Chunwan Lu.
Transl Cancer Res, 2018 Nov 18; 7(Suppl 5). PMID: 30443490    Free PMC article.
Deep Semi Supervised Generative Learning for Automated Tumor Proportion Scoring on NSCLC Tissue Needle Biopsies.
Ansh Kapil, Armin Meier, +4 authors, Nicolas Brieu.
Sci Rep, 2018 Nov 28; 8(1). PMID: 30478349    Free PMC article.
The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response.
Andrea Devecchi, Loris De Cecco, +7 authors, Silvana Pilotti.
Cancer Commun (Lond), 2018 Nov 30; 38(1). PMID: 30486883    Free PMC article.
Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types.
Marcella Tazzari, Silvia Brich, +13 authors, Chiara Castelli.
J Immunol Res, 2018 Dec 05; 2018. PMID: 30510965    Free PMC article.
Impact of PD-L1 expression, driver mutations and clinical characteristics on survival after anti-PD-1/PD-L1 immunotherapy versus chemotherapy in non-small-cell lung cancer: A meta-analysis of randomized trials.
Qingyuan Huang, Hua Zhang, +4 authors, Justin Stebbing.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524878    Free PMC article.
HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer.
Rui Deng, Peng Zhang, +9 authors, Kaixiong Tao.
Clin Epigenetics, 2018 Dec 13; 10(1). PMID: 30537988    Free PMC article.
Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides.
Jun Nakata, Hiroko Nakajima, +12 authors, Haruo Sugiyama.
Oncotarget, 2018 Dec 14; 9(89). PMID: 30542516    Free PMC article.
Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma.
Lukas W Pfannenstiel, Corey McNeilly, +4 authors, Brian R Gastman.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546944    Free PMC article.
Soluble programmed death-1 is a useful indicator for inflammatory and fibrosis severity in chronic hepatitis B.
Liang Zhou, Xiaoyan Li, +3 authors, Yuehua Huang.
J Viral Hepat, 2018 Dec 24; 26(7). PMID: 30578715    Free PMC article.
Fates of CD8+ T cells in Tumor Microenvironment.
Nomathamsanqa Resegofetse Maimela, Shasha Liu, Yi Zhang.
Comput Struct Biotechnol J, 2018 Dec 26; 17. PMID: 30581539    Free PMC article.
Highly Cited. Review.
Role of B7H3/IL-33 Signaling in Pulmonary Fibrosis-induced Profibrogenic Alterations in Bone Marrow.
Taku Nakashima, Tianju Liu, +6 authors, Sem H Phan.
Am J Respir Crit Care Med, 2019 May 21; 200(8). PMID: 31106564    Free PMC article.
Phage display screening of therapeutic peptide for cancer targeting and therapy.
Phei Er Saw, Er-Wei Song.
Protein Cell, 2019 May 30; 10(11). PMID: 31140150    Free PMC article.
Review.
Application of PD-1 Blockade in Cancer Immunotherapy.
Xiaomo Wu, Zhongkai Gu, +4 authors, Xiaolong Liu.
Comput Struct Biotechnol J, 2019 Jun 18; 17. PMID: 31205619    Free PMC article.
Highly Cited. Review.
Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology.
Gabriele Di Sante, Jessica Pagé, +4 authors, Richard G Pestell.
Expert Rev Anticancer Ther, 2019 Jun 21; 19(7). PMID: 31219365    Free PMC article.
Review.
A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma.
Sang-Soo Kim, Joe B Harford, +3 authors, Esther H Chang.
Int J Cancer, 2019 Jun 27; 145(9). PMID: 31241175    Free PMC article.
Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy.
Heng-Huan Lee, Ying-Nai Wang, +15 authors, Mien-Chie Hung.
Cancer Cell, 2019 Jul 23; 36(2). PMID: 31327656    Free PMC article.
Highly Cited.
Comprehensive immune characterization and T-cell receptor repertoire heterogeneity of retroperitoneal liposarcoma.
Liang Yan, Zhen Wang, +6 authors, Chunyi Hao.
Cancer Sci, 2019 Aug 07; 110(10). PMID: 31385405    Free PMC article.
The clinicopathological and prognostic value of PD-L1 in urothelial carcinoma: a meta-analysis.
Yaoan Wen, Yeda Chen, +4 authors, Guohua Zeng.
Clin Exp Med, 2019 Aug 14; 19(4). PMID: 31407099
Review.
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
Zining Wang, Jiemin Chen, +13 authors, Xiaojun Xia.
J Clin Invest, 2019 Aug 14; 129(11). PMID: 31408442    Free PMC article.
Programmed Cell Death Ligand 1 in Breast Cancer: Technical Aspects, Prognostic Implications, and Predictive Value.
Federica Miglietta, Gaia Griguolo, Valentina Guarneri, Maria Vittoria Dieci.
Oncologist, 2019 Aug 25; 24(11). PMID: 31444294    Free PMC article.
Review.
Circulating biomarkers predictive of tumor response to cancer immunotherapy.
Ernest Y Lee, Rajan P Kulkarni.
Expert Rev Mol Diagn, 2019 Aug 31; 19(10). PMID: 31469965    Free PMC article.
Review.
BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response.
Guillaume P Andrieu, Jordan S Shafran, +4 authors, Gerald V Denis.
Cancer Lett, 2019 Sep 02; 465. PMID: 31473251    Free PMC article.
Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development.
Peng Tan, Lian He, +9 authors, Rong-Fu Wang.
J Clin Invest, 2019 Sep 11; 129(12). PMID: 31503548    Free PMC article.
αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion.
Andrea Vannini, Valerio Leoni, +5 authors, Tatiana Gianni.
Proc Natl Acad Sci U S A, 2019 Sep 19; 116(40). PMID: 31527243    Free PMC article.
Blockade of PD-L1 Enhances Cancer Immunotherapy by Regulating Dendritic Cell Maturation and Macrophage Polarization.
Nai-Yun Sun, Yu-Li Chen, +8 authors, Wen-Fang Cheng.
Cancers (Basel), 2019 Sep 25; 11(9). PMID: 31546897    Free PMC article.
Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression.
Chloé Laplagne, Marcin Domagala, +7 authors, Mary Poupot.
Int J Mol Sci, 2019 Sep 25; 20(19). PMID: 31547627    Free PMC article.
Review.
Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11.
Xueting Lang, Michael D Green, +20 authors, Weiping Zou.
Cancer Discov, 2019 Sep 27; 9(12). PMID: 31554642    Free PMC article.
Highly Cited.
In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles.
Yeteng Zhong, Zhuoran Ma, +16 authors, Hongjie Dai.
Nat Biotechnol, 2019 Oct 02; 37(11). PMID: 31570897    Free PMC article.
Three discipline collaborative radiation therapy (3DCRT) special debate: The single most important factor in determining the future of SBRT is immune response.
Clemens Grassberger, Kathryn Huber, +6 authors, Jay Burmeister.
J Appl Clin Med Phys, 2019 Oct 02; 20(10). PMID: 31573143    Free PMC article.
HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma.
Yangzhi Qi, Gang Deng, +6 authors, Qianxue Chen.
Oncol Rep, 2019 Oct 04; 42(6). PMID: 31578594    Free PMC article.
Classical Hodgkin's Lymphoma in the Era of Immune Checkpoint Inhibition.
Valli De Re, Laura Caggiari, +2 authors, Maurizio Mascarin.
J Clin Med, 2019 Oct 05; 8(10). PMID: 31581738    Free PMC article.
Review.
Promising new treatments for pancreatic cancer in the era of targeted and immune therapies.
Ahmed Elaileh, Ashish Saharia, +4 authors, Kirk Heyne.
Am J Cancer Res, 2019 Oct 11; 9(9). PMID: 31598392    Free PMC article.
Review.
CAR-T 19 combined with reduced-dose PD-1 blockade therapy for treatment of refractory follicular lymphoma: A case report.
Jia Wang, Qi Deng, +4 authors, Yu-Ming Li.
Oncol Lett, 2019 Oct 16; 18(5). PMID: 31611950    Free PMC article.
Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors.
Giuseppe Schepisi, Nicole Brighi, +11 authors, Ugo De Giorgi.
J Oncol, 2019 Oct 24; 2019. PMID: 31641355    Free PMC article.
Review.
Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method.
Tal Flieswasser, Valérie Camara-Clayette, +9 authors, Julie Jacobs.
Cancers (Basel), 2019 Oct 28; 11(10). PMID: 31652572    Free PMC article.
Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy.
Liping Huang, Yanan Li, +8 authors, Chunmeng Sun.
Nat Commun, 2019 Oct 28; 10(1). PMID: 31653838    Free PMC article.
Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation.
Mingzhu Wang, Junchao Wang, +4 authors, Min Zhang.
Commun Biol, 2019 Nov 02; 2. PMID: 31667366    Free PMC article.
Red blood cell-derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy.
Xiao Han, Shufang Shen, +6 authors, Chao Wang.
Sci Adv, 2019 Nov 05; 5(10). PMID: 31681841    Free PMC article.
IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer.
Guoping Ding, Tao Shen, +3 authors, Liping Cao.
BMC Cancer, 2019 Nov 07; 19(1). PMID: 31694582    Free PMC article.
PD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis.
Chang E Gao, Ming Zhang, Qian Song, Jian Dong.
Onco Targets Ther, 2019 Nov 07; 12. PMID: 31695411    Free PMC article.
Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer.
Sehui Kim, Ji-Young Jang, +10 authors, Yoon Kyung Jeon.
J Exp Clin Cancer Res, 2019 Nov 14; 38(1). PMID: 31718692    Free PMC article.
Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells.
Kankana Bardhan, Halil-Ibrahim Aksoylar, +6 authors, Vassiliki A Boussiotis.
Sci Rep, 2019 Nov 23; 9(1). PMID: 31754127    Free PMC article.
Fusobacterium nucleatum prevents apoptosis in colorectal cancer cells via the ANO1 pathway.
Pei Lu, Minyi Xu, +2 authors, Lei Wang.
Cancer Manag Res, 2019 Dec 06; 11. PMID: 31802939    Free PMC article.
From Super-Enhancer Non-coding RNA to Immune Checkpoint: Frameworks to Functions.
Manqing Wu, Jun Shen.
Front Oncol, 2019 Dec 12; 9. PMID: 31824865    Free PMC article.
Review.
Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity.
Lucien P Garo, Amrendra K Ajay, +8 authors, Gopal Murugaiyan.
Cell Rep, 2019 Sep 26; 28(13). PMID: 31553906    Free PMC article.
Reduced GRAMD1C expression correlates to poor prognosis and immune infiltrates in kidney renal clear cell carcinoma.
Haiyan Hao, Ziheng Wang, +4 authors, Wei Wang.
PeerJ, 2019 Dec 26; 7. PMID: 31875150    Free PMC article.
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Yunlong Zhao, Calvin K Lee, +8 authors, Enfu Hui.
Immunity, 2019 Nov 24; 51(6). PMID: 31757674    Free PMC article.
PD-L1 Expression and Tumor-Infiltrating Lymphocytes in Thymic Epithelial Neoplasms.
Rumi Higuchi, Taichiro Goto, +6 authors, Masao Omata.
J Clin Med, 2019 Nov 07; 8(11). PMID: 31683962    Free PMC article.
Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors.
Wenyan Zhong, Jeremy S Myers, +11 authors, Paul A Rejto.
BMC Genomics, 2020 Jan 04; 21(1). PMID: 31898484    Free PMC article.
Evaluation of PD-L1 and PD-1 expression in aggressive eyelid sebaceous gland carcinoma and its clinical significance.
Perumal Jayaraj, Seema Sen.
Indian J Ophthalmol, 2019 Nov 23; 67(12). PMID: 31755433    Free PMC article.
Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment.
Yangjing Zhao, Qixiang Shao, Guangyong Peng.
Cell Mol Immunol, 2019 Dec 20; 17(1). PMID: 31853000    Free PMC article.
Review.
Mechanisms Controlling PD-L1 Expression in Cancer.
Jong-Ho Cha, Li-Chuan Chan, +2 authors, Mien-Chie Hung.
Mol Cell, 2019 Nov 02; 76(3). PMID: 31668929    Free PMC article.
Review.
Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma.
Shogo Zuo, Masayuki Sho, +6 authors, Hiroomi Okuyama.
Pediatr Surg Int, 2020 Jan 12; 36(2). PMID: 31925505
Comprehensive Survey of Clinical Trials Registration for Melanoma Immunotherapy in the ClinicalTrials.gov.
Yan-Bo Wang, Gang Lv, +2 authors, Yong-Ming Yao.
Front Pharmacol, 2020 Jan 31; 10. PMID: 31998135    Free PMC article.
B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models.
Baozhu Huang, Liqun Luo, +6 authors, Gangxiong Huang.
Oncoimmunology, 2020 Feb 01; 9(1). PMID: 32002297    Free PMC article.
BTLA Expression in Stage I-III Non-Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes.
Xiangmin Li, Zhaoguo Xu, +2 authors, Xiaoye Zhang.
Onco Targets Ther, 2020 Feb 06; 13. PMID: 32021268    Free PMC article.
Enhanced histone H3 acetylation of the PD-L1 promoter via the COP1/c-Jun/HDAC3 axis is required for PD-L1 expression in drug-resistant cancer cells.
Haifang Wang, Chen Fu, +10 authors, Yurong Qiu.
J Exp Clin Cancer Res, 2020 Feb 07; 39(1). PMID: 32024543    Free PMC article.
Immunotherapy in Ovarian Cancer.
Weimin Wang, Janice Rebecca Liu, Weiping Zou.
Surg Oncol Clin N Am, 2019 May 14; 28(3). PMID: 31079799    Free PMC article.
Review.
Is first-line pembrolizumab appropriate for all patients with metastatic non-squamous histology non-small cell lung cancer patients?
Laura Le, Ritchell van Dams, Percy Lee.
Transl Lung Cancer Res, 2020 Feb 11; 8(Suppl 4). PMID: 32038907    Free PMC article.
The Novel Combination of Nitroxoline and PD-1 Blockade, Exerts a Potent Antitumor Effect in a Mouse Model of Prostate Cancer.
Naijin Xu, Linglong Huang, +9 authors, Peng Huang.
Int J Biol Sci, 2019 Jun 12; 15(5). PMID: 31182913    Free PMC article.
Immune Cell PD-L1 Colocalizes with Macrophages and Is Associated with Outcome in PD-1 Pathway Blockade Therapy.
Yuting Liu, Jon Zugazagoitia, +5 authors, David L Rimm.
Clin Cancer Res, 2019 Oct 17; 26(4). PMID: 31615933    Free PMC article.
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.
Meike E W Logtenberg, J H Marco Jansen, +18 authors, Ton N Schumacher.
Nat Med, 2019 Mar 06; 25(4). PMID: 30833751    Free PMC article.
Highly Cited.
Prevalence of NRAS Mutation, PD-L1 Expression and Amplification, and Overall Survival Analysis in 36 Primary Vaginal Melanomas.
Hai-Yun Wang, Xiao-Yan Wu, +4 authors, Fang Wang.
Oncologist, 2020 Feb 12; 25(2). PMID: 32043781    Free PMC article.
Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors.
Yuki Saito, Takako S Chikenji, +2 authors, Mineko Fujimiya.
Nat Commun, 2020 Feb 16; 11(1). PMID: 32060352    Free PMC article.
Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment.
Ya Luo, Jiqiao Yang, +5 authors, Xuelei Ma.
Front Oncol, 2020 Feb 23; 10. PMID: 32083005    Free PMC article.
Review.
Establishment of humanized tumor microenvironment mouse models based on the injection of peripheral blood mononuclear cells and IFN-γ to evaluate the efficacy of PD-L1/PD-1-targeted immunotherapy.
Xiuyun Lin, Tao Zeng, +7 authors, Jizhen Lin.
Cancer Biol Ther, 2019 Nov 07; 21(2). PMID: 31690181    Free PMC article.
Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy.
Guojun Chen, Zhitong Chen, +6 authors, Zhen Gu.
Proc Natl Acad Sci U S A, 2020 Feb 08; 117(7). PMID: 32029590    Free PMC article.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
Takahiro Kamada, Yosuke Togashi, +13 authors, Hiroyoshi Nishikawa.
Proc Natl Acad Sci U S A, 2019 Apr 28; 116(20). PMID: 31028147    Free PMC article.
Highly Cited.
A comparative characterization of the circulating miRNome in whole blood and serum of HCC patients.
Devis Pascut, Helena Krmac, +4 authors, Claudio Tiribelli.
Sci Rep, 2019 Jun 06; 9(1). PMID: 31164669    Free PMC article.
Therapeutic PD-L1 antibodies are more effective than PD-1 antibodies in blocking PD-1/PD-L1 signaling.
Annika De Sousa Linhares, Claire Battin, +8 authors, Peter Steinberger.
Sci Rep, 2019 Aug 09; 9(1). PMID: 31391510    Free PMC article.
Resistance to Checkpoint Inhibition in Cancer Immunotherapy.
Luisa Barrueto, Francheska Caminero, +3 authors, Rahul R Deshmukh.
Transl Oncol, 2020 Mar 03; 13(3). PMID: 32114384    Free PMC article.
Review.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han.
J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595    Free PMC article.
Highly Cited. Review.
Distinct contribution of PD-L1 suppression by spatial expression of PD-L1 on tumor and non-tumor cells.
Xiaoqing Zhang, Chen Cheng, +4 authors, Xuanming Yang.
Cell Mol Immunol, 2018 Mar 24; 16(4). PMID: 29568117    Free PMC article.
PD-1 blocks lytic granule polarization with concomitant impairment of integrin outside-in signaling in the natural killer cell immunological synapse.
Yu Huang, Zhiying Chen, +10 authors, Dongfang Liu.
J Allergy Clin Immunol, 2018 Apr 22; 142(4). PMID: 29679656    Free PMC article.
S100B and LDH as early prognostic markers for response and overall survival in melanoma patients treated with anti-PD-1 or combined anti-PD-1 plus anti-CTLA-4 antibodies.
Nikolaus B Wagner, Andrea Forschner, +2 authors, Thomas K Eigentler.
Br J Cancer, 2018 Jun 29; 119(3). PMID: 29950611    Free PMC article.
Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy.
Xiaolei Li, Wenhui Song, +2 authors, Weidong Han.
Cell Mol Immunol, 2018 Jul 14; 16(1). PMID: 30002451    Free PMC article.
Review.
Regulation of NK-Cell Function by HLA Class II.
Annika Niehrs, Marcus Altfeld.
Front Cell Infect Microbiol, 2020 Mar 07; 10. PMID: 32133304    Free PMC article.
Loss of VGLL4 suppresses tumor PD-L1 expression and immune evasion.
Ailing Wu, Qingzhe Wu, +7 authors, Hai Song.
EMBO J, 2018 Nov 07; 38(1). PMID: 30396996    Free PMC article.
Spatial and phenotypic immune profiling of metastatic colon cancer.
Jenny Lazarus, Tomasz Maj, +15 authors, Timothy L Frankel.
JCI Insight, 2018 Nov 16; 3(22). PMID: 30429368    Free PMC article.
Immune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinoma.
M Oliva, A Spreafico, +4 authors, L L Siu.
Ann Oncol, 2018 Nov 22; 30(1). PMID: 30462163    Free PMC article.
Review.
Pre- and post-operative anti-PD-L1 plus anti-angiogenic therapies in mouse breast or renal cancer models of micro- or macro-metastatic disease.
Florence T H Wu, Ping Xu, +6 authors, Robert S Kerbel.
Br J Cancer, 2018 Dec 01; 120(2). PMID: 30498230    Free PMC article.
Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.
Hye-Yeong Kim, Ran Li, +8 authors, Miles A Miller.
ACS Nano, 2018 Dec 07; 12(12). PMID: 30508377    Free PMC article.
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer.
Weihua Hou, Qingyun Yuan, +4 authors, Min Yu.
Invest New Drugs, 2018 Dec 05; 37(5). PMID: 30511201
Palmitoylation stabilizes PD-L1 to promote breast tumor growth.
Yi Yang, Jung-Mao Hsu, +8 authors, Mien-Chie Hung.
Cell Res, 2018 Dec 06; 29(1). PMID: 30514902    Free PMC article.
Modulating the Tumor Microenvironment via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy.
Gang Shi, Qianmei Yang, +21 authors, Hongxin Deng.
Mol Ther, 2018 Dec 12; 27(1). PMID: 30527756    Free PMC article.
Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4).
N Boku, M-H Ryu, +13 authors, Y-K Kang.
Ann Oncol, 2018 Dec 20; 30(2). PMID: 30566590    Free PMC article.
Highly Cited.
Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement.
Douglas B Johnson, Mellissa J Nixon, +21 authors, Justin M Balko.
JCI Insight, 2018 Dec 21; 3(24). PMID: 30568030    Free PMC article.
Combined α-programmed death-1 monoclonal antibody blockade and fractionated radiation therapy reduces tumor growth in mouse EL4 lymphoma.
Xiuyun Lin, Tao Zeng, +19 authors, Jizhen Lin.
Cancer Biol Ther, 2018 Dec 24; 20(5). PMID: 30572778    Free PMC article.
Immune-checkpoint inhibitor plus chemotherapy versus conventional chemotherapy for first-line treatment in advanced non-small cell lung carcinoma: a systematic review and meta-analysis.
Yixin Zhou, Chen Chen, +10 authors, Li Zhang.
J Immunother Cancer, 2018 Dec 24; 6(1). PMID: 30577837    Free PMC article.
Systematic Review.
Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance.
Daisuke Muraoka, Naohiro Seo, +17 authors, Hiroshi Shiku.
J Clin Invest, 2019 Jan 11; 129(3). PMID: 30628894    Free PMC article.
Tumor-Targeted Chemoimmunotherapy with Immune-Checkpoint Blockade for Enhanced Anti-Melanoma Efficacy.
Man Li, Yuting Yang, +8 authors, Qin He.
AAPS J, 2019 Jan 13; 21(2). PMID: 30635795
Safety and clinical activity with an anti-PD-1 antibody JS001 in advanced melanoma or urologic cancer patients.
Bixia Tang, Xieqiao Yan, +20 authors, Jun Guo.
J Hematol Oncol, 2019 Jan 16; 12(1). PMID: 30642373    Free PMC article.
Highly Cited.
Engineering Nanoparticles for Targeted Remodeling of the Tumor Microenvironment to Improve Cancer Immunotherapy.
Shan Gao, Dongjuan Yang, +6 authors, Kai Shi.
Theranostics, 2019 Jan 22; 9(1). PMID: 30662558    Free PMC article.
Highly Cited. Review.
WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer.
Lorenzo Castagnoli, Valeria Cancila, +13 authors, Serenella M Pupa.
Oncogene, 2019 Feb 02; 38(21). PMID: 30705400    Free PMC article.
Highly Cited.
Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti-PD-1 in melanoma.
Laurene S Cheung, Juan Fu, +10 authors, William R Bishai.
Proc Natl Acad Sci U S A, 2019 Feb 06; 116(8). PMID: 30718426    Free PMC article.
Divergent SATB1 expression across human life span and tissue compartments.
Simone Nüssing, Hui-Fern Koay, +12 authors, Katherine Kedzierska.
Immunol Cell Biol, 2019 Feb 26; 97(5). PMID: 30803026    Free PMC article.
The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy.
Gui-Zhen Wang, Li Zhang, +11 authors, Guang-Biao Zhou.
Nat Commun, 2019 Mar 10; 10(1). PMID: 30850589    Free PMC article.
Highly Cited.
An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE).
Derek L Clouthier, Scott C Lien, +30 authors, Lillian L Siu.
J Immunother Cancer, 2019 Mar 15; 7(1). PMID: 30867072    Free PMC article.
Mutually assured destruction: the cold war between viruses and natural killer cells.
Ayad Ali, Ivayla E Gyurova, Stephen N Waggoner.
Curr Opin Virol, 2019 Mar 17; 34. PMID: 30877885    Free PMC article.
Review.
Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy.
Karin M Knudson, Kristin C Hicks, +2 authors, Sofia R Gameiro.
J Immunother Cancer, 2019 Mar 23; 7(1). PMID: 30898149    Free PMC article.
Dynamic host immune response in virus-associated cancers.
Song Cao, Kristine M Wylie, +13 authors, Li Ding.
Commun Biol, 2019 Mar 27; 2. PMID: 30911684    Free PMC article.
Bispecific CD3-HAC carried by E1A-engineered mesenchymal stromal cells against metastatic breast cancer by blocking PD-L1 and activating T cells.
Yuanyuan Yang, Xiaolong Zhang, +11 authors, Dongsheng Xiong.
J Hematol Oncol, 2019 Apr 27; 12(1). PMID: 31023384    Free PMC article.
Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside.
Justin Korfhage, David B Lombard.
Mol Cancer Res, 2019 Apr 27; 17(7). PMID: 31023785    Free PMC article.
Review.
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy.
Weimin Wang, Michael Green, +27 authors, Weiping Zou.
Nature, 2019 May 03; 569(7755). PMID: 31043744    Free PMC article.
Highly Cited.
Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy.
Qiang Zhang, Michael D Green, +14 authors, Meredith A Morgan.
Cancer Res, 2019 May 19; 79(15). PMID: 31101760    Free PMC article.
Highly Cited.
Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity.
Xinyue Qi, Fanlin Li, +4 authors, Xuanming Yang.
Nat Commun, 2019 May 21; 10(1). PMID: 31105267    Free PMC article.
The local immune landscape determines tumor PD-L1 heterogeneity and sensitivity to therapy.
Yuan Wei, Qiyi Zhao, +9 authors, Dong-Ming Kuang.
J Clin Invest, 2019 May 22; 129(8). PMID: 31112529    Free PMC article.
Highly Cited.
A novel model of controlling PD-L1 expression in ALK+ anaplastic large cell lymphoma revealed by CRISPR screening.
Jing-Ping Zhang, Zhihui Song, +10 authors, Yibin Yang.
Blood, 2019 Jun 04; 134(2). PMID: 31151983    Free PMC article.
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
Li-Chuan Chan, Chia-Wei Li, +26 authors, Mien-Chie Hung.
J Clin Invest, 2019 Jul 16; 129(8). PMID: 31305264    Free PMC article.
Highly Cited.
A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control.
Zhichen Sun, Zhenhua Ren, +12 authors, Hua Peng.
Nat Commun, 2019 Aug 30; 10(1). PMID: 31462678    Free PMC article.
CD137 ligand feedback upregulates PD-L1 expression on lung cancer via T cell production of IFN-γ.
Helin Wang, Zhuohong Yan, +7 authors, Shucai Zhang.
Thorac Cancer, 2019 Oct 19; 10(12). PMID: 31625289    Free PMC article.
Small molecules as theranostic agents in cancer immunology.
Jindian Li, Juno Van Valkenburgh, +3 authors, Kai Chen.
Theranostics, 2019 Nov 07; 9(25). PMID: 31695804    Free PMC article.
Review.
A Single-Step Chemoenzymatic Reaction for the Construction of Antibody-Cell Conjugates.
Jie Li, Mingkuan Chen, +7 authors, Peng Wu.
ACS Cent Sci, 2019 Jan 17; 4(12). PMID: 30648147    Free PMC article.
Tumor-Infiltrating Lymphocytes in the Checkpoint Inhibitor Era.
Gerald P Linette, Beatriz M Carreno.
Curr Hematol Malig Rep, 2019 Jun 13; 14(4). PMID: 31187421    Free PMC article.
Review.
Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy.
Jung-Ho Kim, Beom Seok Kim, Sang-Kyou Lee.
Immune Netw, 2020 Mar 12; 20(1). PMID: 32158592    Free PMC article.
Review.
Comprehensive molecular profiling of the B7 family in gastrointestinal cancer.
Qijie Zhao, Fuyan Hu, +10 authors, Jing Shen.
Cell Prolif, 2018 Jul 13; 51(5). PMID: 29999557    Free PMC article.
Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer.
Prachya Kongtawelert, Benjawan Wudtiwai, +2 authors, Thanyaluck Phitak.
Molecules, 2020 Jan 16; 25(2). PMID: 31936263    Free PMC article.
Resistance Mechanisms and Barriers to Successful Immunotherapy for Treating Glioblastoma.
Jason Adhikaree, Julia Moreno-Vicente, +2 authors, Poulam M Patel.
Cells, 2020 Jan 25; 9(2). PMID: 31973059    Free PMC article.
Review.
Immune-Related Adverse Events in the Setting of PD-1/L1 Inhibitor Combination Therapy.
Leyre Zubiri, Ian M Allen, +16 authors, Kerry L Reynolds.
Oncologist, 2020 Mar 13; 25(3). PMID: 32162817    Free PMC article.
BRD4 Inhibition by AZD5153 Promotes Antitumor Immunity via Depolarizing M2 Macrophages.
Xi Li, Yu Fu, +10 authors, Gang Chen.
Front Immunol, 2020 Mar 19; 11. PMID: 32184777    Free PMC article.
Advances and challenges in immunotherapy of small cell lung cancer.
Hanfei Guo, Lingyu Li, Jiuwei Cui.
Chin J Cancer Res, 2020 Mar 21; 32(1). PMID: 32194311    Free PMC article.
C-Myc regulates PD-L1 expression in esophageal squamous cell carcinoma.
Ming-Qiang Liang, Feng-Qiang Yu, Chun Chen.
Am J Transl Res, 2020 Mar 21; 12(2). PMID: 32194890    Free PMC article.
T cell recruitment triggered by optimal dose platinum compounds contributes to the therapeutic efficacy of sequential PD-1 blockade in a mouse model of colon cancer.
Deqiang Fu, Jichun Wu, +4 authors, Qiuyu Zhang.
Am J Cancer Res, 2020 Mar 21; 10(2). PMID: 32195021    Free PMC article.
Safety and immunogenicity of a potential checkpoint blockade vaccine for canine melanoma.
Raj K Kurupati, Xiangyang Zhou, +2 authors, Hildegund C J Ertl.
Cancer Immunol Immunother, 2018 Jul 28; 67(10). PMID: 30051333    Free PMC article.
Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect.
Yang Du, Yinhua Jin, +3 authors, Jie Tian.
Eur Radiol, 2018 Dec 07; 29(8). PMID: 30506221    Free PMC article.
Review.
Nanotherapeutics for Immuno-Oncology: A Crossroad for New Paradigms.
Wantong Song, Manisit Das, Xuesi Chen.
Trends Cancer, 2020 Mar 27; 6(4). PMID: 32209444    Free PMC article.
Review.
Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy.
Ryusuke Hatae, Kenji Chamoto, +13 authors, Tasuku Honjo.
JCI Insight, 2019 Dec 20; 5(2). PMID: 31855576    Free PMC article.
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Yan Ge, Haiyan Wang, +10 authors, David L Bartlett.
J Immunother Cancer, 2020 Mar 27; 8(1). PMID: 32209602    Free PMC article.
Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy.
Alok Kumar, Kenji Chamoto, Partha S Chowdhury, Tasuku Honjo.
Elife, 2020 Mar 04; 9. PMID: 32122466    Free PMC article.
Empowering therapeutic antibodies with IFN-α for cancer immunotherapy.
Jun Guo, Yu Xiao, +10 authors, Tzu-Hsuan Huang.
PLoS One, 2019 Aug 09; 14(8). PMID: 31393905    Free PMC article.
Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy.
Xiaodong Wang, Xiaohui Yang, +21 authors, Shan Gao.
Proc Natl Acad Sci U S A, 2020 Mar 13; 117(12). PMID: 32161124    Free PMC article.
Complementing the Cancer-Immunity Cycle.
Ruben Pio, Daniel Ajona, +2 authors, John D Lambris.
Front Immunol, 2019 Apr 30; 10. PMID: 31031765    Free PMC article.
Highly Cited. Review.
Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy.
Hongwei Chen, Xin Luan, +7 authors, Duxin Sun.
Nanomedicine (Lond), 2019 Dec 24; 15(1). PMID: 31868112    Free PMC article.
Prognostic significance of PD-L1 expression on cell-surface vimentin-positive circulating tumor cells in gastric cancer patients.
Mengyuan Liu, Ruoyu Wang, +16 authors, Mingjun Sun.
Mol Oncol, 2020 Jan 26; 14(4). PMID: 31981446    Free PMC article.
A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients.
Jing Yang, Meilian Dong, +9 authors, Yonggang Shi.
Cancer Cell Int, 2020 Apr 08; 20. PMID: 32256205    Free PMC article.
The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells.
Dong Young Kang, Nipin Sp, +7 authors, Young Mok Yang.
Cancers (Basel), 2020 Mar 25; 12(3). PMID: 32204508    Free PMC article.
Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes.
Yonghyo Kim, Jeovanis Gil, +17 authors, György Marko-Varga.
Cancers (Basel), 2020 Mar 28; 12(3). PMID: 32213878    Free PMC article.
IL-36β Promotes CD8+ T Cell Activation and Antitumor Immune Responses by Activating mTORC1.
Xin Zhao, Xiaojuan Chen, +13 authors, Xuefeng Wang.
Front Immunol, 2019 Aug 27; 10. PMID: 31447838    Free PMC article.
New Approaches on Cancer Immunotherapy.
Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, Mien-Chie Hung.
Cold Spring Harb Perspect Med, 2019 Oct 17; 10(8). PMID: 31615865    Free PMC article.
Review.
Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9-genome editing promotes antitumor immunity and suppresses ovarian cancer progression.
Tamaki Yahata, Mika Mizoguchi, +13 authors, Kazuhiko Ino.
Cancer Sci, 2019 Feb 01; 110(4). PMID: 30702189    Free PMC article.
Hypoxia-inducible factor-1α and nuclear factor-κB play important roles in regulating programmed cell death ligand 1 expression by epidermal growth factor receptor mutants in non-small-cell lung cancer cells.
Rong Guo, Yong Li, +5 authors, Jie Wang.
Cancer Sci, 2019 Mar 08; 110(5). PMID: 30844110    Free PMC article.
Rational application of the first-line chemotherapy and immune checkpoint inhibitors in advanced nonsmall cell lung cancer: A meta-analysis.
Rui Cao, Jie-Tao Ma, +6 authors, Cheng-Bo Han.
Cancer Med, 2019 Jul 13; 8(11). PMID: 31297962    Free PMC article.
VISTA: Coming of age as a multi-lineage immune checkpoint.
M A ElTanbouly, E Schaafsma, R J Noelle, J L Lines.
Clin Exp Immunol, 2020 Jan 14; 200(2). PMID: 31930484    Free PMC article.
Review.
Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors.
Rachel Grosser, Leonid Cherkassky, Navin Chintala, Prasad S Adusumilli.
Cancer Cell, 2019 Nov 13; 36(5). PMID: 31715131    Free PMC article.
Review.
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
Jun Wang, Jingwei Sun, +16 authors, Lieping Chen.
Nat Med, 2019 Mar 06; 25(4). PMID: 30833750    Free PMC article.
Highly Cited.
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Abel H Y Tan, WenJuan Tu, +5 authors, Sudha Rao.
Front Immunol, 2019 Jun 30; 10. PMID: 31249575    Free PMC article.
The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.
Jun Gong, Alexander Chehrazi-Raffle, +3 authors, Ravi Salgia.
Clin Transl Med, 2019 Mar 20; 8(1). PMID: 30887236    Free PMC article.
Highly Cited. Review.
CAR T cell therapy: newer approaches to counter resistance and cost.
Rajesh Kumar Yadav, Asgar Ali, +6 authors, Sadhana Sharma.
Heliyon, 2020 Apr 24; 6(4). PMID: 32322738    Free PMC article.
Review.
Histone Deacetylase Inhibition Sensitizes PD1 Blockade-Resistant B-cell Lymphomas.
Xiaoguang Wang, Brittany C Waschke, +5 authors, Jing H Wang.
Cancer Immunol Res, 2019 Jun 27; 7(8). PMID: 31235619    Free PMC article.
Effects of anti-PD-1 immunotherapy on tumor regression: insights from a patient-derived xenograft model.
Asunción Martín-Ruiz, Carmen Fiuza-Luces, +7 authors, Mariano Provencio.
Sci Rep, 2020 Apr 29; 10(1). PMID: 32341383    Free PMC article.
Comprehensive Analysis of the Expression and Prognosis for TDO2 in Breast Cancer.
Qiang Liu, Jie Zhai, +4 authors, Jing Wang.
Mol Ther Oncolytics, 2020 Apr 30; 17. PMID: 32346606    Free PMC article.
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy.
Jing Li, Weichao Wang, +22 authors, Weiping Zou.
J Clin Invest, 2020 Feb 07; 130(5). PMID: 32027624    Free PMC article.
Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer.
Fan Luo, Min Luo, +5 authors, Li-Wu Fu.
J Immunother Cancer, 2019 Sep 13; 7(1). PMID: 31511071    Free PMC article.
Lesion-Level Response Dynamics to Programmed Cell Death Protein (PD-1) Blockade.
Juan C Osorio, Kathryn C Arbour, +14 authors, Matthew D Hellmann.
J Clin Oncol, 2019 Nov 02; 37(36). PMID: 31675272    Free PMC article.
Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation.
Xinfang Yu, Wei Li, +9 authors, Yong Li.
J Hematol Oncol, 2020 May 03; 13(1). PMID: 32357935    Free PMC article.
Prognostic and predictive value of an immune infiltration signature in diffuse lower-grade gliomas.
Lai-Rong Song, Jian-Cong Weng, +7 authors, Jun-Ting Zhang.
JCI Insight, 2020 Apr 02; 5(8). PMID: 32229719    Free PMC article.
Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3-CD8+ T cells.
Sisi Deng, Zhichen Sun, +8 authors, Hua Peng.
JCI Insight, 2020 Apr 10; 5(7). PMID: 32271164    Free PMC article.
Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist.
Karin M Knudson, Kristin C Hicks, +2 authors, Sofia R Gameiro.
J Immunother Cancer, 2020 Apr 19; 8(1). PMID: 32303618    Free PMC article.
Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies.
Alberto Puccini, Francesca Battaglin, +2 authors, Mohamed E Salem.
J Immunother Cancer, 2020 May 13; 8(1). PMID: 32393474    Free PMC article.
Review.
Reactive Oxygen Species in the Tumor Microenvironment: An Overview.
Frank Weinberg, Nithya Ramnath, Deepak Nagrath.
Cancers (Basel), 2019 Aug 21; 11(8). PMID: 31426364    Free PMC article.
Highly Cited. Review.
Anti PD-1 monoclonal antibody induced autoimmune diabetes mellitus: a case report and brief review.
Wei Li, Hao Wang, +6 authors, Caicun Zhou.
Transl Lung Cancer Res, 2020 May 19; 9(2). PMID: 32420079    Free PMC article.
Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti-PD-L1 immunotherapy.
Zhaoting Li, Yixin Wang, +3 authors, Minjie Sun.
Sci Adv, 2020 May 23; 6(20). PMID: 32440550    Free PMC article.
Immunotherapy: Checkpoint Inhibitors in Lynch-Associated Gynecologic Cancers.
J Stuart Ferriss, M Yvette Williams-Brown.
Curr Treat Options Oncol, 2019 Aug 25; 20(10). PMID: 31444655
Review.
Normalization Cancer Immunotherapy for Melanoma.
Matthew D Vesely, Lieping Chen.
J Invest Dermatol, 2020 Feb 25; 140(6). PMID: 32092349    Free PMC article.
Blocking Triggering Receptor Expressed on Myeloid Cells-1-Positive Tumor-Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti-Programmed Cell Death Ligand 1 Resistance in Liver Cancer.
Qinchuan Wu, Wuhua Zhou, +10 authors, Shusen Zheng.
Hepatology, 2019 Feb 28; 70(1). PMID: 30810243    Free PMC article.
Highly Cited.
Endoplasmic Reticulum Stress Causes Liver Cancer Cells to Release Exosomal miR-23a-3p and Up-regulate Programmed Death Ligand 1 Expression in Macrophages.
Jiatao Liu, Lulu Fan, +12 authors, Guoping Sun.
Hepatology, 2019 Mar 12; 70(1). PMID: 30854665    Free PMC article.
Highly Cited.
Extracellular Vesicles in Renal Cell Carcinoma: Multifaceted Roles and Potential Applications Identified by Experimental and Computational Methods.
Zhiyuan Qin, Qingwen Xu, +2 authors, Su Zeng.
Front Oncol, 2020 May 28; 10. PMID: 32457844    Free PMC article.
Review.
Rewiring regulatory T cells for tumour killing.
Tomasz Maj, Weiping Zou.
Nat Biomed Eng, 2019 Aug 07; 3(10). PMID: 31384007    Free PMC article.
Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway.
Chao Liu, Zhaoying Yao, +14 authors, Qianming Du.
Cell Death Differ, 2019 Dec 06; 27(6). PMID: 31802034    Free PMC article.
Diagnostic value of 18F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8+tumour-infiltrating lymphocytes in oral squamous cell carcinoma.
Maria Togo, Takehiko Yokobori, +8 authors, Tetsunari Oyama.
Br J Cancer, 2020 Apr 03; 122(11). PMID: 32238919    Free PMC article.
Prognostic value of programmed cell death ligand-1 expression in ovarian cancer: an updated meta-analysis.
Jinlan Piao, Hyun Ji Lim, Maria Lee.
Obstet Gynecol Sci, 2020 Jun 04; 63(3). PMID: 32489980    Free PMC article.
Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker-based immunotherapy.
Feihu Wang, Dongqing Xu, +11 authors, Honggang Cui.
Sci Adv, 2020 Jun 04; 6(18). PMID: 32490201    Free PMC article.
A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target.
Zachary T Freeman, Thomas R Nirschl, +17 authors, Charles G Drake.
J Clin Invest, 2020 Feb 06; 130(3). PMID: 32015231    Free PMC article.
Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies.
Rong Fu, Yi Li, +9 authors, Zhao-Qiu Wu.
J Clin Invest, 2020 Feb 11; 130(3). PMID: 32039918    Free PMC article.
Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy.
Xia Liu, Daniel F Hoft, Guangyong Peng.
J Clin Invest, 2020 Mar 03; 130(3). PMID: 32118585    Free PMC article.
Review.
PD-L1 produced by HaCaT cells under polyinosinic-polycytidylic acid stimulation inhibits melanin production by B16F10 cells.
Minhwa Park, So-Youn Woo, +2 authors, Kyung Ho Lee.
PLoS One, 2020 May 22; 15(5). PMID: 32437407    Free PMC article.
Tumor immune microenvironment in head and neck cancers.
Samantha M Y Chen, Alexandra L Krinsky, +3 authors, Jing H Wang.
Mol Carcinog, 2020 Feb 06; 59(7). PMID: 32017286    Free PMC article.
Review.
Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity.
Daniel S Leventhal, Anna Sokolovska, +13 authors, Jose M Lora.
Nat Commun, 2020 Jun 03; 11(1). PMID: 32483165    Free PMC article.
Supramolecular Self-Assembled Nanostructures for Cancer Immunotherapy.
Zichao Huang, Wantong Song, Xuesi Chen.
Front Chem, 2020 Jun 13; 8. PMID: 32528926    Free PMC article.
Review.
Expanding the Spectrum of Adenoviral Vectors for Cancer Therapy.
Jian Gao, Wenli Zhang, Anja Ehrhardt.
Cancers (Basel), 2020 May 07; 12(5). PMID: 32370135    Free PMC article.
Review.
DNA hypomethylation promotes transposable element expression and activation of immune signaling in renal cell cancer.
Aguirre A de Cubas, William Dunker, +8 authors, W Kimryn Rathmell.
JCI Insight, 2020 Jun 05; 5(11). PMID: 32493845    Free PMC article.
NF-κB and Its Role in Checkpoint Control.
Annika C Betzler, Marie-Nicole Theodoraki, +4 authors, Cornelia Brunner.
Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486375    Free PMC article.
Review.
Mouse Tumor Models for Advanced Cancer Immunotherapy.
Daria S Chulpanova, Kristina V Kitaeva, +2 authors, Valeriya V Solovyeva.
Int J Mol Sci, 2020 Jun 13; 21(11). PMID: 32526987    Free PMC article.
Review.
The interaction between ferroptosis and lipid metabolism in cancer.
Dingshan Li, Yongsheng Li.
Signal Transduct Target Ther, 2020 Jul 02; 5(1). PMID: 32606298    Free PMC article.
Review.
The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis.
Ying-Nai Wang, Heng-Huan Lee, +2 authors, Mien-Chie Hung.
J Biomed Sci, 2020 Jul 06; 27(1). PMID: 32620165    Free PMC article.
Review.
Mechanistic insight of predictive biomarkers for antitumor PD‑1/PD‑L1 blockade: A paradigm shift towards immunome evaluation (Review).
Wenjie You, Bin Shang, +3 authors, Shujuan Jiang.
Oncol Rep, 2020 Jul 07; 44(2). PMID: 32627031    Free PMC article.
Review.
PD-L1 Expression Affects Neoantigen Presentation.
Masahiro Okada, Kanako Shimizu, +6 authors, Shin-Ichiro Fujii.
iScience, 2020 Jul 08; 23(6). PMID: 32629606    Free PMC article.
Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications.
Lidia Yshii, Chloé Bost, Roland Liblau.
Front Immunol, 2020 Jul 14; 11. PMID: 32655545    Free PMC article.
Review.
Chemoradioimmunotherapy of inoperable stage III non-small cell lung cancer: immunological rationale and current clinical trials establishing a novel multimodal strategy.
Lukas Käsmann, Chukwuka Eze, +6 authors, Farkhad Manapov.
Radiat Oncol, 2020 Jul 11; 15(1). PMID: 32646443    Free PMC article.
Review.
Novel Immunotherapeutic Approaches in Head and Neck Cancer.
M E Heft Neal, C T Haring, +3 authors, P L Swiecicki.
J Cancer Metastasis Treat, 2019 Jan 01; 5. PMID: 32661502    Free PMC article.
Producing Soluble Human Programmed Cell Death Protein-1: A Natural Supporter for CD4+T Cell Cytotoxicity and Tumor Cells Apoptosis.
Samane Mohammadzadeh, Hossein Khanahmad, +4 authors, Alireza Andalib.
Iran J Biotechnol, 2020 Jul 17; 17(4). PMID: 32671122    Free PMC article.
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
Yu Wang, Qingguo Sun, +5 authors, Xiangguo Liu.
Cell Commun Signal, 2020 Jul 16; 18(1). PMID: 32665011    Free PMC article.
Integrating the Tumor Microenvironment into Cancer Therapy.
Sabina Sanegre, Federico Lucantoni, +3 authors, Tomás Álvaro Naranjo.
Cancers (Basel), 2020 Jul 01; 12(6). PMID: 32599891    Free PMC article.
Review.
Converting Immune Cold into Hot by Biosynthetic Functional Vesicles to Boost Systematic Antitumor Immunity.
Ming Wu, Dongye Zheng, +10 authors, Xiaolong Liu.
iScience, 2020 Jul 20; 23(7). PMID: 32683314    Free PMC article.
Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction.
Tingting Wang, J N Rashida Gnanaprakasam, +20 authors, Ruoning Wang.
Nat Metab, 2020 Jul 23; 2(7). PMID: 32694789    Free PMC article.
Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer.
Noffar Bar, Federica Costa, +19 authors, Madhav V Dhodapkar.
JCI Insight, 2020 May 20; 5(12). PMID: 32427579    Free PMC article.
CD73 acts as a prognostic biomarker and promotes progression and immune escape in pancreatic cancer.
Qiangda Chen, Ning Pu, +4 authors, Wenchuan Wu.
J Cell Mol Med, 2020 Jul 10; 24(15). PMID: 32643277    Free PMC article.
Tumor-Associated CD163+ M2 Macrophage Infiltration is Highly Associated with PD-L1 Expression in Cervical Cancer.
Fan Guo, Yang-Chun Feng, +7 authors, Xiu-Min Ma.
Cancer Manag Res, 2020 Aug 09; 12. PMID: 32765086    Free PMC article.
Nanomedicine and Onco-Immunotherapy: From the Bench to Bedside to Biomarkers.
Vanessa Acebes-Fernández, Alicia Landeria-Viñuela, +5 authors, Manuel Fuentes.
Nanomaterials (Basel), 2020 Jul 03; 10(7). PMID: 32610601    Free PMC article.
Review.
Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
Somanath Kallolimath, Thomas Hackl, +6 authors, Herta Steinkellner.
Front Bioeng Biotechnol, 2020 Aug 15; 8. PMID: 32793574    Free PMC article.
Current progress and prospect of immune checkpoint inhibitors in hepatocellular carcinoma.
Zhu Zeng, Biao Yang, Zheng-Yin Liao.
Oncol Lett, 2020 Aug 18; 20(4). PMID: 32802167    Free PMC article.
Review.
[18F]FDG PET immunotherapy radiomics signature (iRADIOMICS) predicts response of non-small-cell lung cancer patients treated with pembrolizumab.
Damijan Valentinuzzi, Martina Vrankar, +9 authors, Robert Jeraj.
Radiol Oncol, 2020 Jul 30; 54(3). PMID: 32726293    Free PMC article.
Subtype and grade-dependent spatial heterogeneity of T-cell infiltration in pediatric glioma.
M Hope Robinson, Juan Vasquez, +4 authors, Kavita Dhodapkar.
J Immunother Cancer, 2020 Aug 14; 8(2). PMID: 32788236    Free PMC article.
Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma.
Jianzhen Lin, Xu Yang, +20 authors, Haitao Zhao.
Hepatobiliary Surg Nutr, 2020 Aug 25; 9(4). PMID: 32832493    Free PMC article.
Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins.
Emelie Foord, Charlotte Klynning, +13 authors, Michael Uhlin.
J Immunol Res, 2020 Aug 25; 2020. PMID: 32832572    Free PMC article.
Ultrathin metal-organic layer-mediated radiotherapy-radiodynamic therapy enhances immunotherapy of metastatic cancers.
Kaiyuan Ni, Guangxu Lan, +5 authors, Wenbin Lin.
Matter, 2020 Aug 25; 1(5). PMID: 32832885    Free PMC article.
Progress in Neoantigen Targeted Cancer Immunotherapies.
Xue-Jiao Han, Xue-Lei Ma, +3 authors, Xia-Wei Wei.
Front Cell Dev Biol, 2020 Aug 28; 8. PMID: 32850843    Free PMC article.
Review.
Resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms, predictive factors, and future perspectives.
Jin-Yu Sun, Dengke Zhang, +4 authors, Jiansong Ji.
Biomark Res, 2020 Aug 31; 8. PMID: 32864132    Free PMC article.
Review.
Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer.
Min Luo, Fang Wang, +5 authors, Liwu Fu.
Signal Transduct Target Ther, 2020 Aug 29; 5(1). PMID: 32855386    Free PMC article.
Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients.
Seung-Myoung Son, Chang Gok Woo, +12 authors, Hye Sook Han.
Sci Rep, 2020 Sep 02; 10(1). PMID: 32868848    Free PMC article.
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance.
Vivek Verma, Rajeev K Shrimali, +25 authors, Samir N Khleif.
Nat Immunol, 2019 Jul 31; 20(9). PMID: 31358999    Free PMC article.
Highly Cited.
The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma.
Joji Nagasaki, Yosuke Togashi, +10 authors, Hiroyoshi Nishikawa.
Blood Adv, 2020 Sep 02; 4(17). PMID: 32870971    Free PMC article.
The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
Cheng-Wei Chou, Ri-Yao Yang, +7 authors, Mien-Chie Hung.
Am J Cancer Res, 2020 Sep 10; 10(8). PMID: 32905506    Free PMC article.
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy.
Yang Gao, Naoe Taira Nihira, +24 authors, Wenyi Wei.
Nat Cell Biol, 2020 Aug 26; 22(9). PMID: 32839551    Free PMC article.
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
Yingjie Bian, Wei Li, +26 authors, Weiping Zou.
Nature, 2020 Sep 04; 585(7824). PMID: 32879489    Free PMC article.
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner.
Qian-Feng Zhang, Jia Li, +7 authors, Bi-Liang Chen.
Theranostics, 2020 Sep 16; 10(23). PMID: 32929370    Free PMC article.
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity.
Ilgen Mender, Anli Zhang, +8 authors, Yang-Xin Fu.
Cancer Cell, 2020 Jul 04; 38(3). PMID: 32619407    Free PMC article.
Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis.
Baihui Li, Bailu Zhang, +6 authors, Lili Yang.
Oncoimmunology, 2020 Sep 18; 9(1). PMID: 32939323    Free PMC article.
Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen-Deuterium Exchange, Cross-linking, and Molecular Docking.
Mengru Mira Zhang, Richard Y-C Huang, +4 authors, Michael L Gross.
Anal Chem, 2020 May 23; 92(13). PMID: 32441507    Free PMC article.
Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis.
Wantong Song, Karthik Tiruthani, +7 authors, Leaf Huang.
Adv Mater, 2018 Nov 06; 30(52). PMID: 30387230    Free PMC article.
Association of B7-H4, PD-L1, and tumor infiltrating lymphocytes with outcomes in breast cancer.
Mehmet Altan, Kelley M Kidwell, +7 authors, David L Rimm.
NPJ Breast Cancer, 2018 Dec 20; 4. PMID: 30564631    Free PMC article.
B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells.
Weiwei Yu, Ling Chen, +2 authors, Lieping Chen.
Oncoimmunology, 2018 Dec 24; 7(11). PMID: 30574431    Free PMC article.
Treatment of advanced hepatocellular carcinoma: immunotherapy from checkpoint blockade to potential of cellular treatment.
Elaine Hon-Lam Siu, Anthony Wing-Hung Chan, +3 authors, Siu Tim Cheung.
Transl Gastroenterol Hepatol, 2019 Jan 04; 3. PMID: 30603725    Free PMC article.
Review.
Analysis of PD-1 related immune transcriptional profile in different cancer types.
Jun Shang, Qian Song, +5 authors, Sihua Wang.
Cancer Cell Int, 2019 Jan 05; 18. PMID: 30607140    Free PMC article.
Identification of hub genes and outcome in colon cancer based on bioinformatics analysis.
Wanli Yang, Jiaojiao Ma, +10 authors, Daiming Fan.
Cancer Manag Res, 2019 Jan 16; 11. PMID: 30643458    Free PMC article.
Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors.
Renata Boldrini, Maria Debora De Pasquale, +11 authors, Doriana Fruci.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713803    Free PMC article.
PDL-1 Antibody Drug Conjugate for Selective Chemo-Guided Immune Modulation of Cancer.
Samaresh Sau, Alex Petrovici, +2 authors, Arun K Iyer.
Cancers (Basel), 2019 Feb 20; 11(2). PMID: 30781490    Free PMC article.
A Feedback Loop Formed by ATG7/Autophagy, FOXO3a/miR-145 and PD-L1 Regulates Stem-Like Properties and Invasion in Human Bladder Cancer.
Junlan Zhu, Yang Li, +6 authors, Chuanshu Huang.
Cancers (Basel), 2019 Mar 16; 11(3). PMID: 30871066    Free PMC article.
The Prognostic and Clinicopathological Roles of PD-L1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Yan Li, Meizhi He, +5 authors, Lang Xie.
Front Pharmacol, 2019 Mar 16; 10. PMID: 30873025    Free PMC article.
Systematic Review.
PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications.
Pramod Darvin, Varun Sasidharan Nair, Eyad Elkord.
J Oncol, 2019 Mar 28; 2019. PMID: 30915120    Free PMC article.
A Changing of the Guard: Immune Checkpoint Inhibitors With and Without Chemotherapy as First Line Treatment for Metastatic Non-small Cell Lung Cancer.
Jose M Pacheco, D Ross Camidge, Robert C Doebele, Erin Schenk.
Front Oncol, 2019 Apr 16; 9. PMID: 30984621    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.
Daniele Lecis, Sabina Sangaletti, Mario P Colombo, Claudia Chiodoni.
Cancers (Basel), 2019 May 08; 11(5). PMID: 31060225    Free PMC article.
Review.
Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy.
Esteban Cruz, Veysel Kayser.
Biologics, 2019 May 24; 13. PMID: 31118560    Free PMC article.
Highly Cited. Review.
MicroRNAs aid the assessment of programmed death ligand 1 expression in patients with non-small cell lung cancer.
Anna Grenda, Marcin Nicoś, +8 authors, Janusz Milanowski.
Oncol Lett, 2019 Jun 13; 17(6). PMID: 31186735    Free PMC article.
Circulating Lymphocytes, PD-L1 Expression on Tumor-infiltrating Lymphocytes, and Survival of Colorectal Cancer Patients with Different Mismatch Repair Gene Status.
Pengfei Kong, Jing Wang, +7 authors, Liangping Xia.
J Cancer, 2019 Jun 18; 10(7). PMID: 31205530    Free PMC article.
Regulation of T cell antitumor immune response by tumor induced metabolic stress.
Fanny Chalmin, Mélanie Bruchard, Frederique Vegran, Francois Ghiringhelli.
Cell Stress, 2019 Jun 22; 3(1). PMID: 31225495    Free PMC article.
Review.
Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent.
Katrijn Broos, Quentin Lecocq, +9 authors, Karine Breckpot.
Cancers (Basel), 2019 Jun 27; 11(6). PMID: 31234464    Free PMC article.
Anti-CD40 mAb enhanced efficacy of anti-PD1 against osteosarcoma.
Jingzhe Zhang, Ye Li, +2 authors, Wenjun Wang.
J Bone Oncol, 2019 Jul 12; 17. PMID: 31293882    Free PMC article.
Integrated assessment of PD-L1 expression and molecular classification facilitates therapy selection and prognosis prediction in gastric cancer.
Yeqi Sun, Wenwei Yu, +6 authors, Lifeng Wang.
Cancer Manag Res, 2019 Aug 03; 11. PMID: 31372044    Free PMC article.
Differential expression of efferocytosis and phagocytosis associated genes in tumor associated macrophages exposed to African American patient derived prostate cancer microenvironment.
Hirendra Banerjee, Christopher Krauss, +8 authors, Santosh Mandal.
J Solid Tumors, 2019 Aug 27; 9(2). PMID: 31447959    Free PMC article.
LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells.
Xinke Wang, Zhixian Lan, +11 authors, Side Liu.
Cancer Cell Int, 2019 Sep 14; 19. PMID: 31516391    Free PMC article.
Immunosuppressive checkpoint Siglec-15: a vital new piece of the cancer immunotherapy jigsaw puzzle.
Xiubao Ren.
Cancer Biol Med, 2019 Sep 14; 16(2). PMID: 31516742    Free PMC article.
The clinicopathological and prognostic significance of PD-L1 expression assessed by immunohistochemistry in lung cancer: a meta-analysis of 50 studies with 11,383 patients.
Huijuan Li, Yangyang Xu, +12 authors, written on behalf of AME Lung Cancer Collaborative Group.
Transl Lung Cancer Res, 2019 Sep 27; 8(4). PMID: 31555517    Free PMC article.
Nanoparticles Presenting Potent TLR7/8 Agonists Enhance Anti-PD-L1 Immunotherapy in Cancer Treatment.
Anton A A Smith, Emily C Gale, +4 authors, Eric A Appel.
Biomacromolecules, 2020 Aug 21; 21(9). PMID: 32816460    Free PMC article.
A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis.
Lin Qin, Jun Cao, +8 authors, Nicholas A Peppas.
Sci Adv, 2020 Sep 13; 6(36). PMID: 32917616    Free PMC article.
HSPA12B Secreted by Tumor-Associated Endothelial Cells Might Induce M2 Polarization of Macrophages via Activating PI3K/Akt/mTOR Signaling.
Jingjie Zhou, Aiping Zhang, Liang Fan.
Onco Targets Ther, 2020 Sep 29; 13. PMID: 32982299    Free PMC article.
Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer.
Junji Akagi, Hideo Baba.
Oncol Lett, 2020 Oct 01; 20(5). PMID: 32994821    Free PMC article.
Hybrid Fc-fused interleukin-7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy.
Ji-Hae Kim, Young-Min Kim, +11 authors, Seung-Woo Lee.
Clin Transl Immunology, 2020 Oct 01; 9(9). PMID: 32994996    Free PMC article.
An implantable blood clot-based immune niche for enhanced cancer vaccination.
Qin Fan, Qingle Ma, +7 authors, Chao Wang.
Sci Adv, 2020 Sep 27; 6(39). PMID: 32978163    Free PMC article.
PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade.
Qi Peng, Xiangyan Qiu, +8 authors, Haidong Tang.
Nat Commun, 2020 Sep 26; 11(1). PMID: 32973173    Free PMC article.
Why the Outcome of Anti-Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers.
Jing H Wang.
Bioessays, 2020 Aug 09; 42(10). PMID: 32767371    Free PMC article.
PD-L1 and prognosis in patients with malignant pleural mesothelioma: a meta-analysis and bioinformatics study.
Liu Jin, Weiling Gu, +3 authors, Zhongwen Chen.
Ther Adv Med Oncol, 2020 Oct 17; 12. PMID: 33062064    Free PMC article.
Prognostic and Immunological Value of Angiotensin-Converting Enzyme 2 in Pan-Cancer.
Huan Feng, Xian Wei, +6 authors, Tao Wang.
Front Mol Biosci, 2020 Oct 23; 7. PMID: 33088807    Free PMC article.
Tumor Immune Microenvironments (TIMEs): Responsive Nanoplatforms for Antitumor Immunotherapy.
Xueqing Sui, Teng Jin, +7 authors, Hua Zhang.
Front Chem, 2020 Oct 24; 8. PMID: 33094098    Free PMC article.
Review.
Estrogen Receptor Downregulates Expression of PD-1/PD-L1 and Infiltration of CD8+ T Cells by Inhibiting IL-17 Signaling Transduction in Breast Cancer.
Chong Shuai, Xinmei Yang, Hongming Pan, Weidong Han.
Front Oncol, 2020 Oct 27; 10. PMID: 33102239    Free PMC article.
Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions.
Guoming Zeng, Libo Jin, +9 authors, Da Sun.
Cancer Manag Res, 2020 Oct 30; 12. PMID: 33116895    Free PMC article.
Review.
Checkpoint therapeutic target database (CKTTD): the first comprehensive database for checkpoint targets and their modulators in cancer immunotherapy.
Yixiao Zhang, Yuan Yao, +15 authors, Yongliang Yang.
J Immunother Cancer, 2020 Oct 29; 8(2). PMID: 33109630    Free PMC article.
Anti-human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation.
Jessica Bridoux, Katrijn Broos, +11 authors, Catarina Xavier.
Biomolecules, 2020 Oct 03; 10(10). PMID: 33003481    Free PMC article.
Targeting Mitochondria in Melanoma.
Sepideh Aminzadeh-Gohari, Daniela D Weber, +3 authors, Roland Lang.
Biomolecules, 2020 Oct 04; 10(10). PMID: 33007949    Free PMC article.
PD-L1 expression in regional lymph nodes and predictable roles in anti-cancer immune responses.
Yoshihiro Komohara, Mamoru Harada, +2 authors, Toshiyuki Nakayama.
J Clin Exp Hematop, 2020 Jul 10; 60(3). PMID: 32641599    Free PMC article.
EZH2 inhibition: a promising strategy to prevent cancer immune editing.
Ning Kang, Mark Eccleston, +4 authors, Francesco Crea.
Epigenomics, 2020 Sep 18; 12(16). PMID: 32938196    Free PMC article.
Review.
β-Catenin regulates tumor-derived PD-L1.
Chuanhui Han, Yang-Xin Fu.
J Exp Med, 2020 Aug 30; 217(11). PMID: 32860048    Free PMC article.
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy.
Weimin Wang, Weiping Zou.
Mol Cell, 2020 Oct 01; 80(3). PMID: 32997964    Free PMC article.
Review.
Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors.
Alexander B Zaslavsky, M P Adams, +18 authors, Ganesh S Palapattu.
Sci Rep, 2020 Nov 11; 10(1). PMID: 33168847    Free PMC article.
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies.
Kaijian Zhou, Shu Guo, +2 authors, Guoxin Liang.
Front Cell Dev Biol, 2020 Nov 13; 8. PMID: 33178688    Free PMC article.
Review.
Study and analysis of antitumor resistance mechanism of PD1/PD-L1 immune checkpoint blocker.
Zhengyi Wang, Xiaoying Wu.
Cancer Med, 2020 Sep 03; 9(21). PMID: 32875727    Free PMC article.
Review.
Development of an IFNγ response-related signature for predicting the survival of cutaneous melanoma.
Baohui Hu, Qian Wei, +8 authors, Lin Zhao.
Cancer Med, 2020 Sep 10; 9(21). PMID: 32902917    Free PMC article.
Prognostic and clinicopathological significance of PD-1 expression in hepatocellular carcinoma: a meta-analysis.
Qian Zhang, Kexiang Zhou, Wei Liang, Wei Xiong.
J Int Med Res, 2020 Oct 27; 48(10). PMID: 33100077    Free PMC article.
TMEM205 Is an Independent Prognostic Factor and Is Associated With Immune Cell Infiltrates in Hepatocellular Carcinoma.
Jiawei Rao, Xukun Wu, +2 authors, Yi Ma.
Front Genet, 2020 Nov 17; 11. PMID: 33193690    Free PMC article.
The Resistance Mechanisms of Lung Cancer Immunotherapy.
Fen Wang, Shubin Wang, Qing Zhou.
Front Oncol, 2020 Nov 17; 10. PMID: 33194652    Free PMC article.
Review.
Prognostic Role of Tumor Mutation Burden Combined With Immune Infiltrates in Skin Cutaneous Melanoma Based on Multi-Omics Analysis.
Junya Yan, Xiaowen Wu, +2 authors, Shundong Cang.
Front Oncol, 2020 Nov 27; 10. PMID: 33240814    Free PMC article.
Checkpoint immunotherapy in head and neck cancers.
Paul Zolkind, Ravindra Uppaluri.
Cancer Metastasis Rev, 2017 Aug 25; 36(3). PMID: 28836124    Free PMC article.
Review.
KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression.
Xiao Albert Zhou, Jiadong Zhou, +13 authors, Jiadong Wang.
Proc Natl Acad Sci U S A, 2020 Oct 29; 117(45). PMID: 33109719    Free PMC article.
Efficacy and safety of anti-PD-1/anti-PD-L1 antibody therapy in treatment of advanced gastric cancer or gastroesophageal junction cancer: A meta-analysis.
Li Yang, Xian-Zhe Dong, +3 authors, Lan Zhang.
World J Gastrointest Oncol, 2020 Dec 01; 12(11). PMID: 33250966    Free PMC article.
Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy.
Weiqiang Zhou, Shanchun Guo, +2 authors, Guangdi Wang.
Curr Med Chem, 2017 Sep 07; 26(17). PMID: 28875842    Free PMC article.
Review.
Bad company: Microenvironmentally mediated resistance to targeted therapy in melanoma.
Filipe V Almeida, Stephen M Douglass, Mitchell E Fane, Ashani T Weeraratna.
Pigment Cell Melanoma Res, 2018 Sep 15; 32(2). PMID: 30216694    Free PMC article.
Review.
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization.
Miguel F Sanmamed, Lieping Chen.
Cell, 2018 Oct 06; 175(2). PMID: 30290139    Free PMC article.
Highly Cited. Review.
Programmed cell death protein-1 (PD-1)/programmed death-ligand-1 (PD-L1) axis in hepatocellular carcinoma: prognostic and therapeutic perspectives.
T Mocan, Z Sparchez, +2 authors, D C Leucuta.
Clin Transl Oncol, 2018 Nov 06; 21(6). PMID: 30387047
Review.
The clinicopathological and prognostic value of programmed death-ligand 1 in colorectal cancer: a meta-analysis.
X Ni, X Sun, +5 authors, J Suo.
Clin Transl Oncol, 2018 Nov 06; 21(5). PMID: 30392153
The correlation and prognostic value of serum levels of soluble programmed death protein 1 (sPD-1) and soluble programmed death-ligand 1 (sPD-L1) in patients with hepatocellular carcinoma.
Boyang Chang, Tao Huang, +9 authors, Peihong Wu.
Cancer Immunol Immunother, 2018 Dec 07; 68(3). PMID: 30506460    Free PMC article.
Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer: a systematic review and meta-analysis.
Zefeng Shen, Lihu Gu, +2 authors, Rongjia Jin.
World J Surg Oncol, 2019 Jan 06; 17(1). PMID: 30609938    Free PMC article.
Systematic Review.
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases.
Zhen Xiang, Yingyan Yu.
Front Med, 2019 Jan 20; 13(1). PMID: 30659409
Review.
The importance of the PD-1/PD-L1 pathway at the maternal-fetal interface.
Matyas Meggyes, Eva Miko, +2 authors, Laszlo Szereday.
BMC Pregnancy Childbirth, 2019 Feb 21; 19(1). PMID: 30782114    Free PMC article.
Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells.
Vladimir N Ivanov, Jinhua Wu, Tony J C Wang, Tom K Hei.
Oncotarget, 2019 Feb 21; 10(8). PMID: 30783513    Free PMC article.
Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis.
Yan Tie, Hui Yang, +4 authors, Ming Liu.
Drug Des Devel Ther, 2019 Feb 23; 13. PMID: 30787594    Free PMC article.
Systematic Review.
Isolation of Tumor-Infiltrating Lymphocytes by Ficoll-Paque Density Gradient Centrifugation.
Yee Sun Tan, Yu L Lei.
Methods Mol Biol, 2019 Feb 25; 1960. PMID: 30798524    Free PMC article.
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives.
Yumeng Wang, Guiling Li.
Front Med, 2019 Mar 04; 13(4). PMID: 30826965
Review.
Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade.
Linan Fang, Dalam Ly, +7 authors, Li Zhang.
J Exp Clin Cancer Res, 2019 Mar 13; 38(1). PMID: 30857561    Free PMC article.
Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function.
Dallas Jones, Christina N Como, +7 authors, Maria A Nagel.
PLoS Pathog, 2019 Mar 15; 15(3). PMID: 30870532    Free PMC article.
The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer.
Jiajing Cai, Qi Qi, +4 authors, Rong Xia.
J Cancer Res Clin Oncol, 2019 Apr 10; 145(6). PMID: 30963235
Review.
Glial Cell Expression of PD-L1.
Priyanka Chauhan, James R Lokensgard.
Int J Mol Sci, 2019 Apr 17; 20(7). PMID: 30987269    Free PMC article.
Review.
Prognostic effect of programmed death-ligand 1 (PD-L1) in ovarian cancer: a systematic review, meta-analysis and bioinformatics study.
Lin Wang.
J Ovarian Res, 2019 May 02; 12(1). PMID: 31039792    Free PMC article.
Systematic Review.
Analysis of the transcriptomic features of microsatellite instability subtype colon cancer.
Haiwei Wang, Xinrui Wang, +2 authors, Hua Cao.
BMC Cancer, 2019 Jun 22; 19(1). PMID: 31221124    Free PMC article.
Transcriptional suppression of the miR-15/16 family by c-Myc in malignant pleural mesothelioma.
Marissa Williams, Yuen Yee Cheng, +7 authors, Glen Reid.
Oncotarget, 2019 Jul 11; 10(41). PMID: 31289611    Free PMC article.
MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function.
Hyun Kyung Ahn, Sehui Kim, +5 authors, Yoon Kyung Jeon.
Int J Mol Sci, 2019 Sep 05; 20(17). PMID: 31480591    Free PMC article.
Advances in engineering local drug delivery systems for cancer immunotherapy.
Peter Abdou, Zejun Wang, +4 authors, Zhen Gu.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020 Apr 08; 12(5). PMID: 32255276    Free PMC article.
Review.
Targeted Delivery of CXCL9 and OX40L by Mesenchymal Stem Cells Elicits Potent Antitumor Immunity.
Pan Yin, Liming Gui, +6 authors, Wei-Qiang Gao.
Mol Ther, 2020 Aug 23; 28(12). PMID: 32827461    Free PMC article.
Heparanase and the hallmarks of cancer.
Krishnath M Jayatilleke, Mark D Hulett.
J Transl Med, 2020 Dec 02; 18(1). PMID: 33256730    Free PMC article.
Review.
Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities.
Minhong Shen, Yibin Kang.
Genes Dev, 2020 Dec 03; 34(23-24). PMID: 33262145    Free PMC article.
Review.
Comprehensive analysis of cutaneous and uveal melanoma liver metastases.
Esmee P Hoefsmit, Elisa A Rozeman, +18 authors, Christian U Blank.
J Immunother Cancer, 2020 Dec 03; 8(2). PMID: 33262254    Free PMC article.
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy.
Yuka Igarashi, Tetsuro Sasada.
J Immunol Res, 2020 Dec 08; 2020. PMID: 33282961    Free PMC article.
Review.
PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo.
Qibin Liao, Yunyu Mao, +3 authors, Jianqing Xu.
Biomark Res, 2020 Dec 10; 8(1). PMID: 33292688    Free PMC article.
Sintilimab: A Promising Anti-Tumor PD-1 Antibody.
Lin Zhang, Wuqian Mai, Wenyang Jiang, Qing Geng.
Front Oncol, 2020 Dec 17; 10. PMID: 33324564    Free PMC article.
Review.
PD-L1-Mediated Immunosuppression in Glioblastoma Is Associated With the Infiltration and M2-Polarization of Tumor-Associated Macrophages.
Zhiyuan Zhu, Hongbo Zhang, +4 authors, Mengqi Gao.
Front Immunol, 2020 Dec 18; 11. PMID: 33329573    Free PMC article.
A20 regulates the therapeutic effect of anti-PD-1 immunotherapy in melanoma.
Weinan Guo, Jinyuan Ma, +17 authors, Chunying Li.
J Immunother Cancer, 2020 Dec 11; 8(2). PMID: 33298620    Free PMC article.
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5.
Yang Liu, Xiaojia Liu, +7 authors, Hongbin Deng.
Acta Pharm Sin B, 2020 Dec 24; 10(12). PMID: 33354502    Free PMC article.
Multi-Omics and Informatics Analysis of FFPE Tissues Derived from Melanoma Patients with Long/Short Responses to Anti-PD1 Therapy Reveals Pathways of Response.
Saurabh K Garg, Eric A Welsh, +7 authors, Joseph Markowitz.
Cancers (Basel), 2020 Dec 02; 12(12). PMID: 33255891    Free PMC article.
Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer.
Laura C Zanetti-Domingues, Scott E Bonner, +2 authors, Veronica Huber.
Cells, 2020 Dec 12; 9(12). PMID: 33302515    Free PMC article.
Review.
Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators.
Tilahun Ayane Debele, Cheng-Fa Yeh, Wen-Pin Su.
Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33333816    Free PMC article.
Review.
Nanobodies as Versatile Tool for Multiscale Imaging Modalities.
Marco Erreni, Tilo Schorn, Francesca D'Autilia, Andrea Doni.
Biomolecules, 2020 Dec 24; 10(12). PMID: 33353213    Free PMC article.
Review.
Tumor-Associated Macrophages in Tumor Immunity.
Yueyun Pan, Yinda Yu, Xiaojian Wang, Ting Zhang.
Front Immunol, 2020 Dec 29; 11. PMID: 33365025    Free PMC article.
Review.
Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway.
Qian Wu, Li Jiang, +3 authors, Ji Cao.
Acta Pharmacol Sin, 2020 Mar 11; 42(1). PMID: 32152439    Free PMC article.
Review.
Programmed cell death 1 (PDCD1) gene haplotypes and susceptibility of patients to basal cell carcinoma.
Farshid Fathi, Batool Zamani, +4 authors, Hossein Motedayyen.
Mol Biol Rep, 2021 Jan 04; 48(3). PMID: 33389528
Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.
Jiaqing Yi, Xuanming Shi, Zhenyu Xuan, Jiang Wu.
Cancer Lett, 2020 Dec 01; 499. PMID: 33253789    Free PMC article.
From biomarkers to therapeutic targets: the promise of PD-L1 in thyroid autoimmunity and cancer.
Grégoire D'Andréa, Sandra Lassalle, +2 authors, Paul Hofman.
Theranostics, 2021 Jan 05; 11(3). PMID: 33391536    Free PMC article.
Review.
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Jiali Yu, Michael D Green, +37 authors, Weiping Zou.
Nat Med, 2021 Jan 06; 27(1). PMID: 33398162    Free PMC article.
Epigenetic modulation of immunotherapy and implications in head and neck cancer.
Liye Zhou, Na Xu, +2 authors, Ravindra Uppaluri.
Cancer Metastasis Rev, 2021 Jan 07; 40(1). PMID: 33403469    Free PMC article.
Review.
AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL.
Zuoqiao Wu, Mary Nicoll, Robert J Ingham.
Exp Hematol Oncol, 2021 Jan 09; 10(1). PMID: 33413671    Free PMC article.
Review.
Host tissue determinants of tumour immunity.
Hélène Salmon, Romain Remark, Sacha Gnjatic, Miriam Merad.
Nat Rev Cancer, 2019 Mar 15; 19(4). PMID: 30867580    Free PMC article.
Highly Cited. Review.
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.
Rilin Deng, Chaohui Zuo, +24 authors, Haizhen Zhu.
Cell Mol Immunol, 2020 Sep 24; 17(11). PMID: 32963356    Free PMC article.
Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens.
Yukie Kashima, Yosuke Togashi, +20 authors, Toshihiko Doi.
Sci Rep, 2021 Jan 13; 11(1). PMID: 33431933    Free PMC article.
RAS-targeted therapies: is the undruggable drugged?
Amanda R Moore, Scott C Rosenberg, Frank McCormick, Shiva Malek.
Nat Rev Drug Discov, 2020 Jun 13; 19(8). PMID: 32528145    Free PMC article.
Review.
The Network of Cytokines in Brain Metastases.
Jawad Fares, Alex Cordero, Deepak Kanojia, Maciej S Lesniak.
Cancers (Basel), 2021 Jan 21; 13(1). PMID: 33466236    Free PMC article.
Review.
Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles.
Zhaohan Wei, Xiaoqiong Zhang, +13 authors, Xiangliang Yang.
Nat Commun, 2021 Jan 21; 12(1). PMID: 33469052    Free PMC article.
The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1.
Hui Li, Xinwei Kuang, +16 authors, Xiang Chen.
Adv Sci (Weinh), 2021 Jan 30; 8(2). PMID: 33510997    Free PMC article.
Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors.
Xingxing Yuan, Zujun Sun, +6 authors, Min Yu.
Invest New Drugs, 2020 Aug 11; 39(1). PMID: 32772342
DNA-protein biomarkers for immunotherapy in the era of precision oncology.
Binnari Kim, So Young Kang, Kyoung-Mee Kim.
J Pathol Transl Med, 2020 Nov 07; 55(1). PMID: 33153244    Free PMC article.
Review.
Mesenchymal traits at the convergence of tumor-intrinsic and -extrinsic mechanisms of resistance to immune checkpoint blockers.
Paola Trono, Antonella Sistigu, +2 authors, Paola Nisticò.
Emerg Top Life Sci, 2017 Dec 12; 1(5). PMID: 33525801    Free PMC article.
Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades.
Jun-Yan Li, Yu-Pei Chen, +2 authors, Jun Ma.
Mol Cancer, 2021 Feb 06; 20(1). PMID: 33541368    Free PMC article.
Review.
PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia.
Bola S Hanna, Philipp M Roessner, +6 authors, Martina Seiffert.
Leukemia, 2018 Dec 24; 33(6). PMID: 30573773
PD-L1 Is an Independent Prognostic Marker in Middle Eastern PTC and Its Expression Is Upregulated by BRAFV600E Mutation.
Abdul K Siraj, Sandeep Kumar Parvathareddy, +4 authors, Khawla S Al-Kuraya.
Cancers (Basel), 2021 Feb 05; 13(3). PMID: 33535609    Free PMC article.
Development and External Validation of a Novel Immune Checkpoint-Related Gene Signature for Prediction of Overall Survival in Hepatocellular Carcinoma.
Enfa Zhao, Shimin Chen, Ying Dang.
Front Mol Biosci, 2021 Feb 09; 7. PMID: 33553243    Free PMC article.
Programmed Cell Death-One Inhibition Therapy in Classical Hodgkin Lymphoma.
Samer A Al-Hadidi, Hubert H Chuang, Roberto N Miranda, Hun Ju Lee.
Clin Lymphoma Myeloma Leuk, 2020 Nov 09; 21(2). PMID: 33160934    Free PMC article.
Review.
Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation.
Sandeep Kumar Parvathareddy, Abdul K Siraj, +3 authors, Khawla S Al-Kuraya.
Sci Rep, 2021 Feb 14; 11(1). PMID: 33580098    Free PMC article.
Immune landscape and therapeutic strategies: new insights into PD-L1 in tumors.
Yuan Wei, Xiao Xiao, +2 authors, Dong-Ming Kuang.
Cell Mol Life Sci, 2020 Sep 18; 78(3). PMID: 32940722
Review.
The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy.
Zhixiao Fang, Chunjie Jiang, Shengli Li.
Front Immunol, 2021 Feb 23; 11. PMID: 33613544    Free PMC article.
Review.
A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy.
Joel Crespo, Yi Ting Koh, +5 authors, Robert J Benschop.
PLoS One, 2021 Feb 18; 16(2). PMID: 33596227    Free PMC article.
Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy.
Xuefei Zhou, Yun Liu, +3 authors, Leaf Huang.
Sci Adv, 2021 Feb 19; 7(8). PMID: 33597232    Free PMC article.
Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy.
Weiqin Jiang, Yinjun He, +9 authors, Hanju Hua.
Front Immunol, 2021 Feb 27; 11. PMID: 33633741    Free PMC article.
Review.
PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer.
Sandeep Kumar Parvathareddy, Abdul K Siraj, +6 authors, Khawla S Al-Kuraya.
Cells, 2021 Jan 29; 10(2). PMID: 33503961    Free PMC article.
Tissue-resident memory-like T cells in tumor immunity: Clinical implications.
Madhav V Dhodapkar, Kavita M Dhodapkar.
Semin Immunol, 2020 Oct 05; 49. PMID: 33011063    Free PMC article.
Review.
Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway.
Thamiris Becker Scheffel, Nathália Grave, +3 authors, Fernanda Bueno Morrone.
Front Oncol, 2021 Mar 05; 10. PMID: 33659213    Free PMC article.
Review.
CRISPR/Cas9 for the Clinician: Current uses of gene editing and applications for new therapeutics in oncology.
Julia Boland, Elena Nedelcu.
Perm J, 2021 Jan 24; 24. PMID: 33482972    Free PMC article.
Review.
Abscopal Effect of Frozen Autograft Reconstruction Combined with an Immune Checkpoint Inhibitor Analyzed Using a Metastatic Bone Tumor Model.
Noritaka Yonezawa, Hideki Murakami, +14 authors, Hiroyuki Tsuchiya.
Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33671258    Free PMC article.
Effects of programmed death ligand 1 on the prognosis of neuroblastoma: A protocol for systematic review and meta analysis.
Zelin Wu, Fenggui Wei, Yawei Zou.
Medicine (Baltimore), 2021 Mar 04; 100(9). PMID: 33655954    Free PMC article.
Systematic Review.
Prediction of Clinical Outcome in Locally Advanced Non-Small Cell Lung Cancer Patients Treated With Chemoradiotherapy by Plasma Markers.
Xin Sui, Leilei Jiang, +9 authors, Weihu Wang.
Front Oncol, 2021 Mar 09; 10. PMID: 33680949    Free PMC article.
The Impact of Programmed Death-Ligand 1 Expression on the Prognosis of Early Stage Resected Non-Small Cell Lung Cancer: A Meta-Analysis of Literatures.
Tao Shi, Shuai Zhu, +8 authors, Song Xu.
Front Oncol, 2021 Mar 13; 11. PMID: 33708622    Free PMC article.
Systematic Review.
Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer.
Guo-Qiang Zhang, Qiong Jiao, +4 authors, Quan-Yong Luo.
Cancer Sci, 2020 Nov 29; 112(3). PMID: 33247999    Free PMC article.
Inhibition of galectin-3 augments the antitumor efficacy of PD-L1 blockade in non-small-cell lung cancer.
Hongxin Zhang, Pengfei Liu, +4 authors, Jianhui Cai.
FEBS Open Bio, 2021 Jan 18; 11(3). PMID: 33455075    Free PMC article.
Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage.
Yuan Hong, Yingcai Feng, +12 authors, Ye Liu.
FEBS Open Bio, 2021 Feb 03; 11(3). PMID: 33527708    Free PMC article.
PD-1 restrains IL-17A production from γδ T cells to modulate acute radiation-induced lung injury.
Yuling Sheng, Kun Chen, +6 authors, Hua Ren.
Transl Lung Cancer Res, 2021 Mar 16; 10(2). PMID: 33718014    Free PMC article.
Identification of an epigenetic prognostic signature for patients with lower-grade gliomas.
Hai Yu, Duanni Zhang, Minxue Lian.
CNS Neurosci Ther, 2021 Jan 19; 27(4). PMID: 33459509    Free PMC article.
Diagnostic Value of Vaginal Microecology, Serum miR-18a, and PD-L1 for Identifying HPV-Positive Cervical Cancer.
Yumei Zhang, Sujuan Qiu, +3 authors, Guolin Hong.
Technol Cancer Res Treat, 2021 Feb 27; 20. PMID: 33632085    Free PMC article.
Current developments of targeting the p53 signaling pathway for cancer treatment.
Jing Huang.
Pharmacol Ther, 2020 Nov 02; 220. PMID: 33130194    Free PMC article.
Review.
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Deyi Zhang, Ryan M Reyes, +12 authors, Tyler J Curiel.
Cancer Med, 2021 Feb 25; 10(6). PMID: 33626233    Free PMC article.
Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.
Aiqin Gao, Xia Liu, +7 authors, Guangyong Peng.
J Immunother Cancer, 2021 Mar 04; 9(3). PMID: 33653799    Free PMC article.
Tumor Microenvironment Analysis Identified Subtypes Associated With the Prognosis and the Tumor Response to Immunotherapy in Bladder Cancer.
Hongxian Zhang, Jiwen Song, +5 authors, Lulin Ma.
Front Genet, 2021 Mar 19; 12. PMID: 33732281    Free PMC article.
Preclinical analysis of novel prognostic transcription factors and immune-related gene signatures for bladder cancer via TCGA-based bioinformatic analysis.
Yuyou Deng, Xin Hong, +5 authors, Xiaofeng Wang.
Oncol Lett, 2021 Mar 23; 21(5). PMID: 33747201    Free PMC article.
Cytosolic Delivery of Thiolated Neoantigen Nano-Vaccine Combined with Immune Checkpoint Blockade to Boost Anti-Cancer T Cell Immunity.
Da Zhang, Ziguo Lin, +12 authors, Xiaolong Liu.
Adv Sci (Weinh), 2021 Mar 23; 8(6). PMID: 33747739    Free PMC article.
Tumor microenvironment characterization in triple-negative breast cancer identifies prognostic gene signature.
Yan Qin, Jiehua Deng, +3 authors, Qiuyun Li.
Aging (Albany NY), 2021 Feb 05; 13(4). PMID: 33536349    Free PMC article.
Autophagy in tumour immunity and therapy.
Houjun Xia, Douglas R Green, Weiping Zou.
Nat Rev Cancer, 2021 Mar 25; 21(5). PMID: 33758415    Free PMC article.
Review.
PD-L1 Expression Is an Independent Marker for Lymph Node Metastasis in Middle Eastern Endometrial Cancer.
Abdul K Siraj, Sandeep Kumar Parvathareddy, +5 authors, Khawla S Al-Kuraya.
Diagnostics (Basel), 2021 Mar 07; 11(3). PMID: 33669153    Free PMC article.
Tissue-resident memory T cells in tumor immunity and immunotherapy.
Karolina Okła, Donna L Farber, Weiping Zou.
J Exp Med, 2021 Mar 24; 218(4). PMID: 33755718    Free PMC article.
Review.
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing.
Zhiru Wang, Wenting Kang, +7 authors, Hong-Min Liu.
Acta Pharm Sin B, 2021 Mar 30; 11(3). PMID: 33777676    Free PMC article.
Progress and Challenges of Predictive Biomarkers for Immune Checkpoint Blockade.
Yanna Lei, Xiaoying Li, +2 authors, Ming Liu.
Front Oncol, 2021 Mar 30; 11. PMID: 33777757    Free PMC article.
Review.
Aging, cancer, and antitumor immunity.
Hideki Ikeda, Yosuke Togashi.
Int J Clin Oncol, 2021 Mar 31; 27(2). PMID: 33783658
Review.
Immunotherapy and predictive immunologic profile: the tip of the iceberg.
Tatiana Cunha Pereira, Paulo Rodrigues-Santos, +7 authors, Gabriela Sousa.
Med Oncol, 2021 Apr 01; 38(5). PMID: 33788049
Review.
Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy.
Xiang Ling, Wenbo Han, +5 authors, Wenbin Lin.
Biomaterials, 2021 Feb 10; 270. PMID: 33561626    Free PMC article.
CD169 Expression on Lymph Node Macrophages Predicts in Patients With Gastric Cancer.
Keiichiro Kumamoto, Takashi Tasaki, +5 authors, Toshiyuki Nakayama.
Front Oncol, 2021 Apr 06; 11. PMID: 33816277    Free PMC article.
Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma.
Barbara Azzimonti, Luca Raimondo, +10 authors, Guido Valente.
Ann Med, 2021 Mar 27; 53(1). PMID: 33769181    Free PMC article.
Type I and II Interferons in the Anti-Tumor Immune Response.
Sarah E Fenton, Diana Saleiro, Leonidas C Platanias.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33801234    Free PMC article.
Review.
Early Evaluation of Immunotherapy Response in Lymphoma Patients by 18F-FDG PET/CT: A Literature Overview.
Cristina Ferrari, Nicola Maggialetti, +4 authors, Giuseppe Rubini.
J Pers Med, 2021 Apr 04; 11(3). PMID: 33803667    Free PMC article.
Review.
Quantitative Assessment of CD200 and CD200R Expression in Lung Cancer.
Ioannis A Vathiotis, Tyler MacNeil, +8 authors, David L Rimm.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33804482    Free PMC article.
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
Jiajia Zhou, Ilona Kryczek, +17 authors, Weiping Zou.
Nat Immunol, 2021 Mar 27; 22(4). PMID: 33767425    Free PMC article.
Remodels the Immunosuppressive Tumor Microenvironment by Combination of Bacillus Calmette-Guérin and Anti-PD-L1 in an Orthotopic Triple-Negative Breast Cancer Mouse Model.
Yuan Lu, Xin Huang, +5 authors, Wenbo He.
Onco Targets Ther, 2021 Apr 10; 14. PMID: 33833524    Free PMC article.
An unexpected role for p53 in regulating cancer cell-intrinsic PD-1 by acetylation.
Zhijie Cao, Ning Kon, +9 authors, Donglai Wang.
Sci Adv, 2021 Apr 02; 7(14). PMID: 33789902    Free PMC article.
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.
Heng Lin, Ilona Kryczek, +23 authors, Weiping Zou.
Cancer Cell, 2021 Jan 30; 39(4). PMID: 33513345    Free PMC article.
Bioinformatics and survival analysis of glia maturation factor-γ in pan-cancers.
Aihua Lan, Chunxia Ren, +2 authors, Gong Yang.
BMC Cancer, 2021 Apr 18; 21(1). PMID: 33863293    Free PMC article.
SQ3370 Activates Cytotoxic Drug via Click Chemistry at Tumor and Elicits Sustained Responses in Injected & Non-injected Lesions.
S Srinivasan, N A Yee, +4 authors, J M Mejia Oneto.
Adv Ther (Weinh), 2021 Apr 20; 4(3). PMID: 33869738    Free PMC article.
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases.
Sulaiman S Alhudaithi, Rashed M Almuqbil, +5 authors, Sandro R P da Rocha.
Mol Pharm, 2020 Nov 11; 17(12). PMID: 33170724    Free PMC article.
Decreased expression of programmed death-1 on CD8+ effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes.
Yimei Shan, Yinghong Kong, +11 authors, Ji Hu.
Acta Diabetol, 2021 Apr 24; 58(9). PMID: 33890177
EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer.
Katherine L Morel, Anjali V Sheahan, +34 authors, Leigh Ellis.
Nat Cancer, 2021 Apr 27; 2(4). PMID: 33899001    Free PMC article.
Frontiers and Opportunities: Highlights of the 2nd Annual Conference of the Chinese Antibody Society.
Hongyu Zhang, Mi Deng, +5 authors, Mitchell Ho.
Antib Ther, 2018 Nov 09; 1(2). PMID: 30406214    Free PMC article.
Absence of association between pretransplant serum soluble programmed death protein-1 level and prognosis following living donor liver transplantation in patients with hepatocellular carcinoma.
Byeong-Gon Na, Yun Kyu Kim, +13 authors, Sung-Gyu Lee.
Medicine (Baltimore), 2021 Apr 29; 100(17). PMID: 33907121    Free PMC article.
Programmed Death Ligand-1 (PD-L1) Is an Independent Negative Prognosticator in Western-World Gallbladder Cancer.
Thomas Albrecht, Fritz Brinkmann, +12 authors, Benjamin Goeppert.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33918309    Free PMC article.
Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy.
Diedie Li, Chengzhi Gao, +5 authors, Jing Xie.
Molecules, 2021 May 01; 26(8). PMID: 33921892    Free PMC article.
Review.
Nanoparticle-based approaches to target the lymphatic system for antitumor treatment.
Xingzhou Peng, Junjie Wang, +2 authors, Zhihong Zhang.
Cell Mol Life Sci, 2021 May 09; 78(12). PMID: 33963442
Review.
Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity.
Yiwen Zhang, Hongrong Hu, +12 authors, Hui Zhang.
J Immunother Cancer, 2021 Apr 23; 9(4). PMID: 33883257    Free PMC article.
Myeloid-derived suppressor cells regulate the immunosuppressive functions of PD-1-PD-L1+ Bregs through PD-L1/PI3K/AKT/NF-κB axis in breast cancer.
Min Liu, Feng Wei, +7 authors, Qian Sun.
Cell Death Dis, 2021 May 11; 12(5). PMID: 33967272    Free PMC article.
Functional bionanomaterials for cell surface engineering in cancer immunotherapy.
Sheng Ma, Yudi Xu, Wantong Song.
APL Bioeng, 2021 May 14; 5(2). PMID: 33981940    Free PMC article.
Review.
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.
Gaopeng Li, Ilona Kryczek, +15 authors, Weiping Zou.
Nat Cell Biol, 2021 May 08; 23(5). PMID: 33958760    Free PMC article.
Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients.
Kaifeng Jin, Yifan Cao, +13 authors, Jiejie Xu.
Oncoimmunology, 2021 May 18; 10(1). PMID: 33996266    Free PMC article.
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.
Wuchang Zhang, Wei Liu, +5 authors, Cun-Yu Wang.
Mol Cell, 2021 Mar 21; 81(10). PMID: 33743195    Free PMC article.
A preclinical study: correlation between PD-L1 PET imaging and the prediction of therapy efficacy of MC38 tumor with 68Ga-labeled PD-L1 targeted nanobody.
Songbing Qin, Yang Yu, +7 authors, Xiaorong Sun.
Aging (Albany NY), 2021 Apr 29; 13(9). PMID: 33910164    Free PMC article.
Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study.
Nikolaus B Wagner, Max M Lenders, +36 authors, Thomas K Eigentler.
J Immunother Cancer, 2021 May 15; 9(5). PMID: 33986126    Free PMC article.
The Genomic Landscape of Thyroid Cancer Tumourigenesis and Implications for Immunotherapy.
Amandeep Singh, Jeehoon Ham, +3 authors, Cheok Soon Lee.
Cells, 2021 Jun 03; 10(5). PMID: 34062862    Free PMC article.
Review.
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade.
Xiaoming Dai, Xia Bu, +14 authors, Wenyi Wei.
Mol Cell, 2021 Apr 29; 81(11). PMID: 33909988    Free PMC article.
Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma.
Thanpisit Lomphithak, Perawatt Akara-Amornthum, +7 authors, Siriporn Jitkaew.
Sci Rep, 2021 Jun 05; 11(1). PMID: 34083572    Free PMC article.
CAR T-cell therapy for pleural mesothelioma: Rationale, preclinical development, and clinical trials.
Navin K Chintala, David Restle, +5 authors, Prasad S Adusumilli.
Lung Cancer, 2021 May 12; 157. PMID: 33972125    Free PMC article.
Review.
Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas.
Farah Succaria, Pia Kvistborg, +10 authors, Janis M Taube.
Cancer Immunol Immunother, 2020 Oct 31; 70(5). PMID: 33125511    Free PMC article.
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1.
Dan Zhu, Ruidan Xu, +4 authors, Xiaofeng Zheng.
Cell Death Differ, 2020 Dec 18; 28(6). PMID: 33328570    Free PMC article.
A size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids.
Jiaolin Wen, Neng Qiu, +6 authors, Lijuan Chen.
Drug Deliv, 2021 Jun 04; 28(1). PMID: 34078185    Free PMC article.
Mechanism-based treatment of cancer with immune checkpoint inhibitor therapies.
Yara Abdou, Manu Pandey, +3 authors, Marc S Ernstoff.
Br J Clin Pharmacol, 2020 Apr 24; 86(9). PMID: 32323342    Free PMC article.
Review.
Precise medicine of programmed cell death-1/programmed cell death 1 ligand 1 inhibitor immunotherapy combined radiotherapy for inoperable advanced lung cancer: A protocol for systematic review and meta-analysis.
Gang Liu, Xiaolan Lv, Yanling Ding, Yongbo Guo.
Medicine (Baltimore), 2021 Jun 16; 100(24). PMID: 34128893    Free PMC article.
Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer.
Yanlei Liu, Jingxing Yang, +9 authors, Daxiang Cui.
Nanomicro Lett, 2021 Jun 18; 12(1). PMID: 34138126    Free PMC article.
Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis.
Shanshan Gou, Shuai Wang, +10 authors, Yanfeng Gao.
Theranostics, 2021 Jun 24; 11(15). PMID: 34158852    Free PMC article.
Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker.
Karima Oualla, Luis Castelo Branco, +4 authors, Nawfel Mellas.
Cancer Control, 2021 Apr 09; 28. PMID: 33827280    Free PMC article.
Critical role of the CD44lowCD62Llow CD8+ T cell subset in restoring antitumor immunity in aged mice.
Yuka Nakajima, Kenji Chamoto, Takuma Oura, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2021 Jun 06; 118(23). PMID: 34088845    Free PMC article.
Non-cationic Material Design for Nucleic Acid Delivery.
Ziwen Jiang, S Thayumanavan.
Adv Ther (Weinh), 2020 Mar 01; 3(3). PMID: 34164572    Free PMC article.
Synthesis of Multifunctional Nanoparticles for the Combination of Photodynamic Therapy and Immunotherapy.
Mei-Hwa Lee, James L Thomas, +3 authors, Hung-Yin Lin.
Pharmaceuticals (Basel), 2021 Jun 03; 14(6). PMID: 34073468    Free PMC article.
Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy.
Julie Niogret, Hélène Berger, +15 authors, Fanny Chalmin.
J Immunother Cancer, 2021 Jun 10; 9(6). PMID: 34103351    Free PMC article.
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.
Lin Gao, Liliang Xia, +3 authors, Shun Lu.
Transl Oncol, 2021 Jun 16; 14(9). PMID: 34130052    Free PMC article.
Turning enemies into allies-reprogramming tumor-associated macrophages for cancer therapy.
Martina Molgora, Marco Colonna.
Med (N Y), 2021 Jul 01; 2(6). PMID: 34189494    Free PMC article.
Review.
Icaritin inhibits PD-L1 expression by Targeting Protein IκB Kinase α.
Dongliang Mo, Hai Zhu, +12 authors, Kun Meng.
Eur J Immunol, 2020 Dec 24; 51(4). PMID: 33354776    Free PMC article.
FXYD6 Regulates Chemosensitivity by Mediating the Expression of Na+/K+-ATPase α1 and Affecting Cell Autophagy and Apoptosis in Colorectal Cancer.
Wen Luo, Qingan Liu, +5 authors, Xiangling Wang.
Biomed Res Int, 2021 Jul 03; 2021. PMID: 34212047    Free PMC article.
Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy.
Hongbo Zhang, Yu Xia, +7 authors, Yi Zou.
Molecules, 2021 Jul 03; 26(11). PMID: 34199417    Free PMC article.
PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma.
Takahiro Hongo, Hidetaka Yamamoto, +12 authors, Yoshinao Oda.
Mod Pathol, 2021 Jul 05; 34(11). PMID: 34218257
Checkpoint Inhibition Therapy in Transplant-Ineligible Relapsed or Refractory Classic Hodgkin Lymphoma.
Samer A Al-Hadidi, Hun Ju Lee.
JCO Oncol Pract, 2021 Jan 13; 17(2). PMID: 33434064    Free PMC article.
Consider the chemokines: a review of the interplay between chemokines and T cell subset function.
Marianne Strazza, Adam Mor.
Discov Med, 2017 Sep 28; 24(130). PMID: 28950073    Free PMC article.
Review.
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Guoxu Zheng, Zhangyan Guo, +6 authors, Lintao Jia.
Signal Transduct Target Ther, 2021 Jun 24; 6(1). PMID: 34158475    Free PMC article.
Prognostic and Therapeutic Implications of Immune Classification by CD8+ Tumor-Infiltrating Lymphocytes and PD-L1 Expression in Sinonasal Squamous Cell Carcinoma.
Rocío García-Marín, Sara Reda, +7 authors, Mario A Hermsen.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34203211    Free PMC article.
Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab.
Toshiki Iwai, Masamichi Sugimoto, +7 authors, Osamu Kondoh.
Sci Rep, 2021 Jul 08; 11(1). PMID: 34230534    Free PMC article.
The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells.
Zongcai Liu, Fen Ning, +9 authors, Li Liu.
Cancer Commun (Lond), 2021 Jul 09; 41(1). PMID: 34236149    Free PMC article.
Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy.
Jiahuan Zou, Hongwei Xia, +5 authors, Feng Bi.
Cancer Sci, 2021 May 03; 112(7). PMID: 33934451    Free PMC article.
[Cardiotoxicity of Anti-PD-L1 Antibody and the Effect of Levothyroxine 
in Attenuating the Related Mortality in Mice].
Zhenyin Chen, Min Wang, +3 authors, Guangbiao Zhou.
Zhongguo Fei Ai Za Zhi, 2021 Jun 23; 24(6). PMID: 34157799    Free PMC article.
circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation.
Lingfei Jia, Yilun Wang, Cun-Yu Wang.
Adv Sci (Weinh), 2021 Jul 15; 8(13). PMID: 34258151    Free PMC article.
KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1.
Rupal S Bhatt, Abdulla Berjis, +16 authors, Gordon J Freeman.
Cancer Immunol Res, 2020 Nov 25; 9(2). PMID: 33229411    Free PMC article.
Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death.
Feiyang Jin, Di Liu, +2 authors, Yongzhong Du.
Int J Nanomedicine, 2021 Jul 17; 16. PMID: 34267518    Free PMC article.
Review.
Identification of mouse helper epitopes for WT1-specific CD4+ T cells.
Hiroko Nakajima, Jun Nakata, +14 authors, Haruo Sugiyama.
Cancer Immunol Immunother, 2021 Jul 18; 70(11). PMID: 34272593
Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.
Wan Du, Fang Hua, +18 authors, Weiping Zou.
Cancer Discov, 2021 Feb 26; 11(7). PMID: 33627378    Free PMC article.
Immune Checkpoint Blockade for Metastatic Uveal Melanoma: Patterns of Response and Survival According to the Presence of Hepatic and Extrahepatic Metastasis.
Elias A T Koch, Anne Petzold, +30 authors, On Behalf Of The German Dermatologic Cooperative Oncology Group DeCOG Committee Ocular Melanoma.
Cancers (Basel), 2021 Jul 21; 13(13). PMID: 34283061    Free PMC article.
Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential.
Espen Basmo Ellingsen, Sara M Mangsbo, Eivind Hovig, Gustav Gaudernack.
Front Immunol, 2021 Jul 23; 12. PMID: 34290704    Free PMC article.
Review.
Mechanisms and Clinical Trials of Hepatocellular Carcinoma Immunotherapy.
Shao-Li Huang, Yu-Ming Wang, +5 authors, Hong-Wu Xin.
Front Genet, 2021 Jul 27; 12. PMID: 34306031    Free PMC article.
Review.
Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum.
Priyanka Chakraborty, Emily L Chen, +3 authors, Jason A Somarelli.
Comput Struct Biotechnol J, 2021 Jul 27; 19. PMID: 34306571    Free PMC article.
The Efficacy of Anti-PD-L1 Treatment in Melanoma Is Associated with the Expression of the ECM Molecule EMILIN2.
Albina Fejza, Maurizio Polano, +5 authors, Eva Andreuzzi.
Int J Mol Sci, 2021 Jul 25; 22(14). PMID: 34299131    Free PMC article.
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis.
Constantinos Roufas, Ilias Georgakopoulos-Soares, Apostolos Zaravinos.
NAR Cancer, 2021 Jul 29; 3(1). PMID: 34316699    Free PMC article.
A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment.
A Farias, A Soto, +5 authors, P M Berguer.
Sci Rep, 2021 Jul 30; 11(1). PMID: 34321536    Free PMC article.
Current Trends of Immunotherapy in the Treatment of Cutaneous Melanoma: A Review.
Piyu Parth Naik.
Dermatol Ther (Heidelb), 2021 Aug 03; 11(5). PMID: 34339016    Free PMC article.
Review.
ENO1 promotes antitumor immunity by destabilizing PD-L1 in NSCLC.
Chunyi Zhang, Kunpeng Zhang, Jie Gu, Di Ge.
Cell Mol Immunol, 2021 Jun 09; 18(8). PMID: 34099892    Free PMC article.
Cross-Link-Functionalized Nanoparticles for Rapid Excretion in Nanotheranostic Applications.
Zhuoran Ma, Feifei Wang, +6 authors, Hongjie Dai.
Angew Chem Weinheim Bergstr Ger, 2021 Aug 03; 132(46). PMID: 34334834    Free PMC article.
NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1.
Xiaozhen Zhang, Xing Huang, +10 authors, Tingbo Liang.
Nat Commun, 2021 Jul 29; 12(1). PMID: 34315872    Free PMC article.
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Qingyun Yuan, Qiaoyan Liang, +5 authors, Min Yu.
Oncoimmunology, 2021 Aug 06; 10(1). PMID: 34350059    Free PMC article.
Automated tumor proportion score analysis for PD-L1 (22C3) expression in lung squamous cell carcinoma.
Jingxin Liu, Qiang Zheng, +14 authors, Yuan Li.
Sci Rep, 2021 Aug 07; 11(1). PMID: 34354151    Free PMC article.
ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer.
Zongren Wang, Xueling Zhang, +11 authors, Lan Shao.
J Immunother Cancer, 2021 Jul 25; 9(7). PMID: 34301812    Free PMC article.
IFNγ signaling integrity in colorectal cancer immunity and immunotherapy.
Wan Du, Timothy L Frankel, Michael Green, Weiping Zou.
Cell Mol Immunol, 2021 Aug 14; 19(1). PMID: 34385592    Free PMC article.
Review.
Histone deacetylase 2 knockout suppresses immune escape of triple-negative breast cancer cells via downregulating PD-L1 expression.
Pengfei Xu, Wei Xiong, +3 authors, Yaochen Li.
Cell Death Dis, 2021 Aug 09; 12(8). PMID: 34365463    Free PMC article.
Current status and quality of radiomic studies for predicting immunotherapy response and outcome in patients with non-small cell lung cancer: a systematic review and meta-analysis.
Qiuying Chen, Lu Zhang, +7 authors, Shuixing Zhang.
Eur J Nucl Med Mol Imaging, 2021 Aug 18; 49(1). PMID: 34402924
Systematic Review.
Programmed Death Ligand 1 Is Overexpressed in Liver Macrophages in Chronic Liver Diseases, and Its Blockade Improves the Antibacterial Activity Against Infections.
Elisa Pose, Mar Coll, +14 authors, Pere Ginès.
Hepatology, 2020 Nov 22; 74(1). PMID: 33219516    Free PMC article.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence.
Ying Xu, Guan-Hua Su, +3 authors, Yi-Zhou Jiang.
Signal Transduct Target Ther, 2021 Aug 22; 6(1). PMID: 34417437    Free PMC article.
Review.
N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer.
Zhenchuan Liu, Tingting Wang, +6 authors, Yongxin Zhou.
Mol Cancer, 2021 Aug 22; 20(1). PMID: 34416901    Free PMC article.
Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity.
Yingzhong Li, Zhijun Su, +7 authors, Ron Weiss.
Nat Cancer, 2021 Aug 28; 1(9). PMID: 34447945    Free PMC article.
Role of the Immune System Elements in Pulmonary Arterial Hypertension.
Michał Tomaszewski, Dominika Bębnowska, +4 authors, Ewelina Grywalska.
J Clin Med, 2021 Aug 28; 10(16). PMID: 34442052    Free PMC article.
Review.
Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis.
Edyta Zyla, Bogdan Musielak, Tad A Holak, Grzegorz Dubin.
Molecules, 2021 Aug 28; 26(16). PMID: 34443436    Free PMC article.
PDL1-positive exosomes suppress antitumor immunity by inducing tumor-specific CD8+ T cell exhaustion during metastasis.
Ji Chen, Yang Song, +6 authors, Xiaofeng Chen.
Cancer Sci, 2021 Jun 22; 112(9). PMID: 34152672    Free PMC article.
Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner.
Kailiang Zhao, Qiang Zhang, +9 authors, Meredith A Morgan.
Mol Cancer Res, 2021 May 29; 19(9). PMID: 34045311    Free PMC article.
Immune Check Point Inhibitors in Primary Cutaneous T-Cell Lymphomas: Biologic Rationale, Clinical Results and Future Perspectives.
Gabriele Roccuzzo, Silvia Giordano, +7 authors, Pietro Quaglino.
Front Oncol, 2021 Sep 07; 11. PMID: 34485162    Free PMC article.
Review.
Direct and Indirect Regulators of Epithelial-Mesenchymal Transition-Mediated Immunosuppression in Breast Carcinomas.
Anushka Dongre, Mohammad Rashidian, +8 authors, Robert A Weinberg.
Cancer Discov, 2020 Dec 18; 11(5). PMID: 33328216    Free PMC article.
The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy.
Wenxiao Jiang, Shuya Pan, +2 authors, Xueqiong Zhu.
Mol Cancer, 2021 Sep 10; 20(1). PMID: 34496886    Free PMC article.
Review.
Ki-67 as a Prognostic Biomarker in Invasive Breast Cancer.
Matthew G Davey, Sean O Hynes, +2 authors, Aoife J Lowery.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503265    Free PMC article.
Review.
Anticancer Activities of Hesperidin via Suppression of Up-Regulated Programmed Death-Ligand 1 Expression in Oral Cancer Cells.
Benjawan Wudtiwai, Anupong Makeudom, +2 authors, Prachya Kongtawelert.
Molecules, 2021 Sep 11; 26(17). PMID: 34500779    Free PMC article.
Targeting the Microenvironment in Esophageal Cancer.
Lei Wang, Huiqiong Han, +3 authors, Yanru Qin.
Front Cell Dev Biol, 2021 Sep 14; 9. PMID: 34513829    Free PMC article.
Review.
Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges.
Shu-Jin Li, Jia-Xian Chen, Zhi-Jun Sun.
Cancer Commun (Lond), 2021 Jun 18; 41(9). PMID: 34137513    Free PMC article.
Review.
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors.
Brett Hopkins, Hongjun Zhang, +20 authors, Yongxin Han.
ACS Med Chem Lett, 2021 Sep 18; 12(9). PMID: 34531952    Free PMC article.
Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers.
Ming Yi, Mengke Niu, +7 authors, Kongming Wu.
J Hematol Oncol, 2021 Sep 17; 14(1). PMID: 34526097    Free PMC article.
Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
Wenjing Qian, Mingfang Zhao, Ruoyu Wang, Heming Li.
J Hematol Oncol, 2021 Sep 17; 14(1). PMID: 34526102    Free PMC article.
Review.
Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD.
Felix Ritzmann, Kai Borchardt, +9 authors, Christoph Beisswenger.
Am J Physiol Lung Cell Mol Physiol, 2021 Mar 25; 320(5). PMID: 33759577    Free PMC article.
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy.
Jinhua Liu, Zichao Chen, +3 authors, Zhen Zhang.
Front Pharmacol, 2021 Sep 21; 12. PMID: 34539412    Free PMC article.
Review.
Prevalence of programmed death ligand-1 in patients diagnosed with non-small cell lung cancer in Lebanon.
Ghina Fakhri, Reem Akel, +6 authors, Arafat Tfayli.
SAGE Open Med, 2021 Sep 21; 9. PMID: 34540227    Free PMC article.
PD-L1-Mediated Immunosuppression in Oral Squamous Cell Carcinoma: Relationship With Macrophage Infiltration and Epithelial to Mesenchymal Transition Markers.
Tiantian Wu, Caijin Tang, +3 authors, Cong Feng.
Front Immunol, 2021 Sep 24; 12. PMID: 34552581    Free PMC article.
Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases.
Yuqi Zhang, Ziran Qin, +2 authors, Fangfang Zhou.
Front Immunol, 2021 Sep 25; 12. PMID: 34557182    Free PMC article.
Review.
Dynamic EMT: a multi-tool for tumor progression.
Simone Brabletz, Harald Schuhwerk, Thomas Brabletz, Marc P Stemmler.
EMBO J, 2021 Aug 31; 40(18). PMID: 34459003    Free PMC article.
Review.
Comprehensive Analysis of the Immune Infiltrates of Pyroptosis in Kidney Renal Clear Cell Carcinoma.
Zhuolun Sun, Changying Jing, +5 authors, Hanbo Wang.
Front Oncol, 2021 Sep 28; 11. PMID: 34568046    Free PMC article.
Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges.
Guoqiang Sun, Dawei Rong, +7 authors, Yangbai Sun.
Front Cell Dev Biol, 2021 Sep 28; 9. PMID: 34568317    Free PMC article.
Review.
Immune Checkpoints in Cancers: From Signaling to the Clinic.
Céline Pisibon, Amira Ouertani, +2 authors, Yann Cheli.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572799    Free PMC article.
Review.
Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy.
Pedro Bule, Sandra Isabel Aguiar, Frederico Aires-Da-Silva, Joana Nunes Ribeiro Dias.
Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34575965    Free PMC article.
Review.
Safety and Efficacy of Anti-CD19-Chimeric Antigen Receptor T Cell Combined With Programmed Cell Death 1 Inhibitor Therapy in a Patient With Refractory Post-Transplant Lymphoproliferative Disease: Case Report and Literature Review.
Gang Feng, Qing Li, +4 authors, Qi Deng.
Front Oncol, 2021 Oct 05; 11. PMID: 34604065    Free PMC article.
B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer.
Jiayu Wang, Hongya Wu, +9 authors, Tongguo Shi.
Cell Death Discov, 2021 Sep 20; 7(1). PMID: 34537815    Free PMC article.
Augmenting the therapeutic window of radiotherapy: A perspective on molecularly targeted therapies and nanomaterials.
Moataz Reda, Alexander F Bagley, Husam Y Zaidan, Wassana Yantasee.
Radiother Oncol, 2020 Jul 01; 150. PMID: 32598976    Free PMC article.
Review.
Ferroptosis: A New Promising Target for Lung Cancer Therapy.
Rui Xiong, Ruyuan He, +4 authors, Qing Geng.
Oxid Med Cell Longev, 2021 Oct 08; 2021. PMID: 34616505    Free PMC article.
Review.
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β.
Fu Du, Xin Qi, +6 authors, Jing Li.
Exp Mol Med, 2021 Sep 23; 53(9). PMID: 34548615    Free PMC article.
Microbiota and Colorectal Cancer: From Gut to Bedside.
Miguel Silva, Valentina Brunner, Markus Tschurtschenthaler.
Front Pharmacol, 2021 Oct 19; 12. PMID: 34658896    Free PMC article.
Review.
Gram-negative microbiota is related to acute exacerbation in children with asthma.
Yoon Hee Kim, Haerin Jang, +9 authors, Myung Hyun Sohn.
Clin Transl Allergy, 2021 Oct 21; 11(8). PMID: 34667591    Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang.
Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187    Free PMC article.
Multi-Omics Data Analyses Identify B7-H3 as a Novel Prognostic Biomarker and Predict Response to Immune Checkpoint Blockade in Head and Neck Squamous Cell Carcinoma.
Wanzun Lin, Yanyan Xu, +6 authors, Jiade J Lu.
Front Immunol, 2021 Oct 23; 12. PMID: 34675936    Free PMC article.
Editorial: Genetic and Epigenetic Control of Immune Responses.
Satish Kumar R Noonepalle, Lidia Karabon, Katherine B Chiappinelli, Alejandro Villagra.
Front Immunol, 2021 Oct 23; 12. PMID: 34675944    Free PMC article.
Emerging concepts in PD-1 checkpoint biology.
Kristen E Pauken, James A Torchia, +2 authors, Gordon J Freeman.
Semin Immunol, 2021 May 20; 52. PMID: 34006473    Free PMC article.
Review.
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Kazuhiro Koikawa, Shin Kibe, +24 authors, Kun Ping Lu.
Cell, 2021 Aug 14; 184(18). PMID: 34388391    Free PMC article.
Immune checkpoint blockade in the treatment of malignant tumor: current statue and future strategies.
Wenwen Yang, Caining Lei, +5 authors, Tiankang Guo.
Cancer Cell Int, 2021 Nov 04; 21(1). PMID: 34727927    Free PMC article.
Review.
MET overexpression contributes to STAT4-PD-L1 signaling activation associated with tumor-associated, macrophages-mediated immunosuppression in primary glioblastomas.
Qiang-Wei Wang, Li-Hua Sun, +13 authors, Zhao-Shi Bao.
J Immunother Cancer, 2021 Oct 21; 9(10). PMID: 34667077    Free PMC article.
Multiomics analysis of tumor mutational burden across cancer types.
Lin Li, Long Bai, +6 authors, Keshuo Ding.
Comput Struct Biotechnol J, 2021 Nov 09; 19. PMID: 34745455    Free PMC article.
Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR.
Xiaojia Liu, Mingxiao Yin, +7 authors, Hongbin Deng.
Acta Pharm Sin B, 2021 Nov 09; 11(10). PMID: 34745852    Free PMC article.
Predictive Value of Multiparametric MRI for Response to Single-Cycle Induction Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma.
Konstantin Hellwig, Stephan Ellmann, +12 authors, Tobias Bäuerle.
Front Oncol, 2021 Nov 09; 11. PMID: 34745957    Free PMC article.
Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity.
Jingya Guo, Yong Liang, +5 authors, Hua Peng.
Cell Res, 2021 Aug 12; 31(11). PMID: 34376814    Free PMC article.
Investigation of the relationship between immune checkpoints and mismatch repair deficiency in recurrent and nonrecurrent glioblastoma
Emel Çakır, İsmail Saygın, Mustafa Emre Ercin.
Turk J Med Sci, 2021 Feb 19; 51(4). PMID: 33600097    Free PMC article.
Neutrophils Extracellular Traps Inhibition Improves PD-1 Blockade Immunotherapy in Colorectal Cancer.
Hongji Zhang, Yu Wang, +12 authors, Allan Tsung.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771497    Free PMC article.
Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy.
Zaigang Zhou, Ning Jiang, +5 authors, Jianliang Shen.
J Nanobiotechnology, 2021 Nov 20; 19(1). PMID: 34794446    Free PMC article.
Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo.
Huapan Fang, Zhaopei Guo, +5 authors, Xuesi Chen.
Nat Commun, 2021 Nov 20; 12(1). PMID: 34795289    Free PMC article.
Dl-3-N-Butylphthalide Presents Anti-Cancer Activity in Lung Cancer by Targeting PD-1/PD-L1 Signaling.
Qian Jiang, Nan Zhang, +3 authors, Lei Liu.
Cancer Manag Res, 2021 Nov 20; 13. PMID: 34795530    Free PMC article.
Lipid-induced S-palmitoylation as a Vital Regulator of Cell Signaling and Disease Development.
Mengyuan Qu, Xuan Zhou, Xiaotong Wang, Honggang Li.
Int J Biol Sci, 2021 Nov 23; 17(15). PMID: 34803494    Free PMC article.
Review.
Programmed Cell Death Ligand 1 Is Enriched in Mammary Stem Cells and Promotes Mammary Development and Regeneration.
Ruirui Wang, Fujing Huang, +5 authors, Cheguo Cai.
Front Cell Dev Biol, 2021 Nov 23; 9. PMID: 34805179    Free PMC article.
Posttranslational Modifications in PD-L1 Turnover and Function: From Cradle to Grave.
Xinfang Yu, Wei Li, Ken H Young, Yong Li.
Biomedicines, 2021 Nov 28; 9(11). PMID: 34829931    Free PMC article.
Review.
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Ensong Guo, Rourou Xiao, +18 authors, Gang Chen.
J Exp Med, 2021 Nov 27; 219(1). PMID: 34825915    Free PMC article.
LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade.
Yi Liu, Brian Debo, +3 authors, Yang Shi.
Nat Commun, 2021 Nov 26; 12(1). PMID: 34819502    Free PMC article.
Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer.
Rajendra Kumar, Janet Mendonca, +22 authors, Sushant K Kachhap.
Cancer Res, 2021 Oct 15; 81(23). PMID: 34645612    Free PMC article.
TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment.
Shusuke Kawashima, Takashi Inozume, +18 authors, Yosuke Togashi.
J Immunother Cancer, 2021 Nov 20; 9(11). PMID: 34795004    Free PMC article.
A Novel Strategy Conjugating PD-L1 Polypeptide With Doxorubicin Alleviates Chemotherapeutic Resistance and Enhances Immune Response in Colon Cancer.
Maolin Wang, Xing-Sheng Shu, +8 authors, Ying Ying.
Front Oncol, 2021 Dec 04; 11. PMID: 34858817    Free PMC article.
Cross-Talk Between Tumor Cells Undergoing Epithelial to Mesenchymal Transition and Natural Killer Cells in Tumor Microenvironment in Colorectal Cancer.
Ana Vuletić, Katarina Mirjačić Martinović, +3 authors, Milena Čavić.
Front Cell Dev Biol, 2021 Dec 04; 9. PMID: 34858978    Free PMC article.
Review.
Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma.
Fang Wen, Shuai Ruan, +6 authors, Peng Shu.
Front Med (Lausanne), 2021 Dec 04; 8. PMID: 34859010    Free PMC article.
Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications.
Hannah-Lou Schilling, Gunther Glehr, +9 authors, Katharina Kronenberg.
Front Immunol, 2021 Dec 07; 12. PMID: 34868015    Free PMC article.
Identification of a Novel Ferroptosis-Related Gene Prediction Model for Clinical Prognosis and Immunotherapy of Colorectal Cancer.
Ya-Bing Yang, Jia-Xin Zhou, +3 authors, Yun-Long Pan.
Dis Markers, 2021 Dec 07; 2021. PMID: 34868393    Free PMC article.