Tumor-associated macrophages and anti-tumor therapies: complex links

Cristina Belgiovine ¹, Maurizio D'Incalci ², Paola Allavena ³, Roberta Frapolli ²

Affiliations

¹ Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy. cristina.belgiovine@humanitasresearch.it.
² Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156, Milan, Italy.
³ Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy.

PMID: 26956893
172 References
34 citations

Abstract

Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression and limit the response to anti-tumor therapies. As a matter of fact, TAMs may have a dual role while interfering with cancer treatments, as they can either promote or impair their functionality. Here we review the connection between macrophages and anticancer therapies; moreover, we provide an overview of the different strategies to target or re-program TAMs for therapeutic purposes.

Keywords: Anti-tumor therapies; Cancer-related inflammation; Macrophage targeting; Nanoparticles; Tumor-associated macrophages.

Other Links

Full text on Cellular and molecular life sciences : CMLS

References
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