Review
. 2016 Apr; 8(4):218.
doi: 10.3390/nu8040218.

Nutritional Genomics and the Mediterranean Diet's Effects on Human Cardiovascular Health

Montserrat Fitó 1 Valentini Konstantinidou 2 
Affiliations
  • PMID: 27089360
  •     55 References
  •     13 citations

Abstract

The synergies and cumulative effects among different foods and nutrients are what produce the benefits of a healthy dietary pattern. Diets and dietary patterns are a major environmental factor that we are exposed to several times a day. People can learn how to control this behavior in order to promote healthy living and aging, and to prevent diet-related diseases. To date, the traditional Mediterranean diet has been the only well-studied pattern. Stroke incidence, a number of classical risk factors including lipid profile and glycaemia, emergent risk factors such as the length of telomeres, and emotional eating behavior can be affected by genetic predisposition. Adherence to the Mediterranean diet could exert beneficial effects on these risk factors. Our individual genetic make-up should be taken into account to better prevent these traits and their subsequent consequences in cardiovascular disease development. In the present work, we review the results of nutritional genomics explaining the role of the Mediterranean diet in human cardiovascular disease. A multidisciplinary approach is necessary to extract knowledge from large-scale data.

Keywords: dietary pattern; nutrigenetics; prevention.

Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial.
Ramon Estruch, Miguel Angel Martínez-González, +14 authors, PREDIMED Study Investigators.
Ann Intern Med, 2006 Jul 05; 145(1). PMID: 16818923
Highly Cited.
Effects of interventions on oxidative stress and inflammation of cardiovascular diseases.
Sewon Lee, Yoonjung Park, +2 authors, Cuihua Zhang.
World J Cardiol, 2011 Feb 03; 3(1). PMID: 21286214    Free PMC article.
The diet and 15-year death rate in the seven countries study.
A Keys, A Menotti, +7 authors, M H Keys.
Am J Epidemiol, 1986 Dec 01; 124(6). PMID: 3776973
Highly Cited.
Integrative analysis of 111 reference human epigenomes.
Roadmap Epigenomics Consortium, Anshul Kundaje, +93 authors, Manolis Kellis.
Nature, 2015 Feb 20; 518(7539). PMID: 25693563    Free PMC article.
Highly Cited.
Association of Mediterranean diet with peripheral artery disease: the PREDIMED randomized trial.
Miguel Ruiz-Canela, Ramón Estruch, +2 authors, Miguel A Martínez-González.
JAMA, 2014 Jan 23; 311(4). PMID: 24449321
Mediterranean dietary pattern in a randomized trial: prolonged survival and possible reduced cancer rate.
M de Lorgeril, P Salen, +3 authors, N Mamelle.
Arch Intern Med, 1998 Jun 13; 158(11). PMID: 9625397
Primary prevention of cardiovascular disease with a Mediterranean diet.
Ramón Estruch, Emilio Ros, +16 authors, PREDIMED Study Investigators.
N Engl J Med, 2013 Feb 26; 368(14). PMID: 23432189
Highly Cited.
The emergence of proton nuclear magnetic resonance metabolomics in the cardiovascular arena as viewed from a clinical perspective.
Naomi J Rankin, David Preiss, +4 authors, Naveed Sattar.
Atherosclerosis, 2014 Oct 10; 237(1). PMID: 25299963    Free PMC article.
Review.
Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women.
Lorena González-Guardia, Elena María Yubero-Serrano, +9 authors, José López-Miranda.
J Gerontol A Biol Sci Med Sci, 2014 Jul 06; 70(1). PMID: 24986061
How does the Mediterranean diet promote cardiovascular health? Current progress toward molecular mechanisms: gene-diet interactions at the genomic, transcriptomic, and epigenomic levels provide novel insights into new mechanisms.
Dolores Corella, José M Ordovás.
Bioessays, 2014 Apr 08; 36(5). PMID: 24706458
The influence of Mediterranean, carbohydrate and high protein diets on gut microbiota composition in the treatment of obesity and associated inflammatory state.
Patricia Lopez-Legarrea, Nicholas Robert Fuller, +2 authors, Ian Douglas Caterson.
Asia Pac J Clin Nutr, 2014 Aug 29; 23(3). PMID: 25164445
Review.
Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study.
Marta Guasch-Ferré, Frank B Hu, +19 authors, Jordi Salas-Salvadó.
BMC Med, 2014 Jun 03; 12. PMID: 24886626    Free PMC article.
Vascular effects of the Mediterranean diet-part II: role of omega-3 fatty acids and olive oil polyphenols.
Egeria Scoditti, Cristiano Capurso, Antonio Capurso, Marika Massaro.
Vascul Pharmacol, 2014 Dec 03; 63(3). PMID: 25446163
Review.
Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease.
Andrea Ganna, Samira Salihovic, +12 authors, Erik Ingelsson.
PLoS Genet, 2014 Dec 17; 10(12). PMID: 25502724    Free PMC article.
Highly Cited.
Dietary Approaches to Stop Hypertension (DASH) diet: applicability and acceptability to a UK population.
K E Harnden, K N Frayn, L Hodson.
J Hum Nutr Diet, 2009 Oct 22; 23(1). PMID: 19843201
Beneficial effect of CLOCK gene polymorphism rs1801260 in combination with low-fat diet on insulin metabolism in the patients with metabolic syndrome.
Antonio Garcia-Rios, Francisco Jesus Gomez-Delgado, +10 authors, Pablo Perez-Martinez.
Chronobiol Int, 2013 Dec 18; 31(3). PMID: 24328727
Sex hormonal regulation and hormesis in aging and longevity: role of vitagenes.
V Calabrese, G Scapagnini, +7 authors, A R Genazzani.
J Cell Commun Signal, 2014 Nov 09; 8(4). PMID: 25381162    Free PMC article.
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg.
Nat Rev Genet, 2008 Jan 17; 9(2). PMID: 18197166
Highly Cited. Review.
In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial.
Valentini Konstantinidou, Maria-Isabel Covas, +9 authors, Montserrat Fito.
FASEB J, 2010 Feb 25; 24(7). PMID: 20179144
Up-to date knowledge on the in vivo transcriptomic effect of the Mediterranean diet in humans.
Valentini Konstantinidou, Maria-Isabel Covas, Rosa Sola, Montserrat Fitó.
Mol Nutr Food Res, 2013 Feb 19; 57(5). PMID: 23417868
Review.
How to interpret a genome-wide association study.
Thomas A Pearson, Teri A Manolio.
JAMA, 2008 Mar 20; 299(11). PMID: 18349094
Highly Cited.
Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site.
Kris Richardson, Jennifer A Nettleton, +43 authors, Jose M Ordovas.
Am J Hum Genet, 2012 Dec 19; 92(1). PMID: 23246289    Free PMC article.
Pro12Ala polymorphism of the PPARγ2 gene interacts with a mediterranean diet to prevent telomere shortening in the PREDIMED-NAVARRA randomized trial.
Sonia García-Calzón, Miguel A Martínez-González, +5 authors, Amelia Marti.
Circ Cardiovasc Genet, 2014 Nov 20; 8(1). PMID: 25406242
An integrated encyclopedia of DNA elements in the human genome.
ENCODE Project Consortium.
Nature, 2012 Sep 08; 489(7414). PMID: 22955616    Free PMC article.
Highly Cited.
The immune system in children with malnutrition--a systematic review.
Maren Johanne Heilskov Rytter, Lilian Kolte, +2 authors, Vibeke Brix Christensen.
PLoS One, 2014 Aug 26; 9(8). PMID: 25153531    Free PMC article.
Highly Cited. Systematic Review.
MicroRNAs: promising new antiangiogenic targets in cancer.
Sandra Gallach, Silvia Calabuig-Fariñas, Eloisa Jantus-Lewintre, Carlos Camps.
Biomed Res Int, 2014 Sep 10; 2014. PMID: 25197665    Free PMC article.
Review.
'The way to a man's heart is through his gut microbiota'--dietary pro- and prebiotics for the management of cardiovascular risk.
Kieran M Tuohy, Francesca Fava, Roberto Viola.
Proc Nutr Soc, 2014 Feb 06; 73(2). PMID: 24495527
Review.
Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities.
Muin J Khoury, Sholom Wacholder.
Am J Epidemiol, 2008 Nov 22; 169(2). PMID: 19022826    Free PMC article.
MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial.
Dolores Corella, Jose V Sorlí, +19 authors, Jose M Ordovás.
Am J Clin Nutr, 2014 Jul 06; 100(2). PMID: 24990426
Changes in ultrasound-assessed carotid intima-media thickness and plaque with a Mediterranean diet: a substudy of the PREDIMED trial.
Aleix Sala-Vila, Edwin-Saúl Romero-Mamani, +10 authors, Emilio Ros.
Arterioscler Thromb Vasc Biol, 2013 Nov 29; 34(2). PMID: 24285581
Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock.
Gad Asher, Paolo Sassone-Corsi.
Cell, 2015 Mar 31; 161(1). PMID: 25815987
Highly Cited. Review.
Putting the balance back in diet.
Stephen J Simpson, David G Le Couteur, David Raubenheimer.
Cell, 2015 Mar 31; 161(1). PMID: 25815981
Highly Cited.
Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial.
Jordi Salas-Salvadó, Monica Bulló, +10 authors, PREDIMED Study Investigators.
Diabetes Care, 2010 Oct 12; 34(1). PMID: 20929998    Free PMC article.
Highly Cited.
Personalized nutrition and cardiovascular disease prevention: From Framingham to PREDIMED.
Valentini Konstantinidou, Lidia Daimiel, Lidia Angeles Daimiel Ruiz, Jose M Ordovás.
Adv Nutr, 2014 May 16; 5(3). PMID: 24829490    Free PMC article.
In vivo transcriptomic profile after a Mediterranean diet in high-cardiovascular risk patients: a randomized controlled trial.
Olga Castañer, Dolores Corella, +9 authors, PREDIMED study investigators.
Am J Clin Nutr, 2013 Aug 02; 98(3). PMID: 23902780
The Mediterranean diet: culture, health and science.
Lorenzo M Donini, Lluis Serra-Majem, +2 authors, Jordi Salas-Salvadó.
Br J Nutr, 2015 Jul 08; 113 Suppl 2. PMID: 26148911
Metabolomic pattern analysis after mediterranean diet intervention in a nondiabetic population: a 1- and 3-year follow-up in the PREDIMED study.
Rosa Vázquez-Fresno, Rafael Llorach, +8 authors, Cristina Andres-Lacueva.
J Proteome Res, 2014 Oct 30; 14(1). PMID: 25353684
Many roads to maturity: microRNA biogenesis pathways and their regulation.
Julia Winter, Stephanie Jung, +2 authors, Sven Diederichs.
Nat Cell Biol, 2009 Mar 04; 11(3). PMID: 19255566
Highly Cited. Review.
A Mediterranean dietary style influences TNF-alpha and VCAM-1 coronary blood levels in unstable angina patients.
Manuel Serrano-Martinez, Mercedes Palacios, +5 authors, Miguel Angel Martinez-Gonzalez.
Eur J Nutr, 2005 Sep 10; 44(6). PMID: 16151968
A metabolomics-driven approach to predict cocoa product consumption by designing a multimetabolite biomarker model in free-living subjects from the PREDIMED study.
Mar Garcia-Aloy, Rafael Llorach, +8 authors, Cristina Andres-Lacueva.
Mol Nutr Food Res, 2014 Oct 10; 59(2). PMID: 25298021
Nutrigenomics: goals and strategies.
Michael Müller, Sander Kersten.
Nat Rev Genet, 2003 Apr 03; 4(4). PMID: 12671662
Review.
Influence of nutrient-derived metabolites on lymphocyte immunity.
Marc Veldhoen, Cristina Ferreira.
Nat Med, 2015 Jun 30; 21(7). PMID: 26121194
Review.
Extravirgin olive oil consumption reduces risk of atrial fibrillation: the PREDIMED (Prevención con Dieta Mediterránea) trial.
Miguel Á Martínez-González, Estefanía Toledo, +19 authors, PREDIMED Investigators.
Circulation, 2014 May 03; 130(1). PMID: 24787471
Novel multimetabolite prediction of walnut consumption by a urinary biomarker model in a free-living population: the PREDIMED study.
Mar Garcia-Aloy, Rafael Llorach, +8 authors, Cristina Andres-Lacueva.
J Proteome Res, 2014 Jun 03; 13(7). PMID: 24882253
DNA methylation, ageing and the influence of early life nutrition.
Karen A Lillycrop, Samuel P Hoile, Leonie Grenfell, Graham C Burdge.
Proc Nutr Soc, 2014 Jul 17; 73(3). PMID: 25027290
Review.
Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population.
Dolores Corella, Paula Carrasco, +20 authors, José M Ordovás.
Diabetes Care, 2013 Aug 15; 36(11). PMID: 23942586    Free PMC article.
CLOCK 3111 T/C SNP interacts with emotional eating behavior for weight-loss in a Mediterranean population.
Gemma López-Guimerà, Hassan S Dashti, +3 authors, Marta Garaulet.
PLoS One, 2014 Jun 07; 9(6). PMID: 24905098    Free PMC article.
Effects of short- and long-term Mediterranean-based dietary treatment on plasma LC-QTOF/MS metabolic profiling of subjects with metabolic syndrome features: The Metabolic Syndrome Reduction in Navarra (RESMENA) randomized controlled trial.
Isabel Bondia-Pons, José Alfredo Martinez, +4 authors, Maria de los Ángeles Zulet.
Mol Nutr Food Res, 2015 Feb 03; 59(4). PMID: 25641909
Exploration of PPAR functions by microarray technology--a paradigm for nutrigenomics.
Meike Bünger, Guido J E J Hooiveld, Sander Kersten, Michael Müller.
Biochim Biophys Acta, 2007 Jul 17; 1771(8). PMID: 17632033
Review.
Adherence to a Mediterranean diet and survival in a Greek population.
Antonia Trichopoulou, Tina Costacou, Christina Bamia, Dimitrios Trichopoulos.
N Engl J Med, 2003 Jun 27; 348(26). PMID: 12826634
Highly Cited.
From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
Katarzyna Szarc vel Szic, Ken Declerck, Melita Vidaković, Wim Vanden Berghe.
Clin Epigenetics, 2015 Apr 11; 7. PMID: 25861393    Free PMC article.
Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk.
Vicenta Llorente-Cortés, Ramón Estruch, +5 authors, Lina Badimon.
Atherosclerosis, 2009 Aug 29; 208(2). PMID: 19712933
Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial.
Carolina Ortega-Azorín, Jose V Sorlí, +18 authors, Dolores Corella.
Circ Cardiovasc Genet, 2014 Jan 23; 7(1). PMID: 24448738
Mediterranean diet and cardiovascular health: Teachings of the PREDIMED study.
Emilio Ros, Miguel A Martínez-González, +4 authors, Dolores Corella.
Adv Nutr, 2014 May 16; 5(3). PMID: 24829485    Free PMC article.
Review.
Food for the brain.
Charles S Zuker.
Cell, 2015 Mar 31; 161(1). PMID: 25815979
Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention.
Montserrat Fitó, Olle Melander, +3 authors, Dolores Corella.
Int J Mol Sci, 2016 Sep 07; 17(9). PMID: 27598147    Free PMC article.
Review.
Plant-based foods containing cell wall polysaccharides rich in specific active monosaccharides protect against myocardial injury in rat myocardial infarction models.
Sun Ha Lim, Yaesil Kim, +4 authors, Jongwon Lee.
Sci Rep, 2016 Dec 09; 6. PMID: 27929093    Free PMC article.
Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin.
Martina C Meinke, Ceylan K Nowbary, +3 authors, Maxim E Darvin.
Nutrients, 2017 Jul 30; 9(7). PMID: 28753935    Free PMC article.
Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes.
Firoozeh Hosseini-Esfahani, Gelareh Koochakpoor, +3 authors, Fereidoun Azizi.
Nutrients, 2017 Sep 29; 9(10). PMID: 28954439    Free PMC article.
Nutritional habits, risk, and progression of Parkinson disease.
Roberto Erro, Francesco Brigo, +3 authors, Michele Tinazzi.
J Neurol, 2017 Oct 12; 265(1). PMID: 29018983
Review.
Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study.
Rodrigo San-Cristobal, Santiago Navas-Carretero, +23 authors, J Alfredo Martinez.
Nutrients, 2017 Oct 12; 9(10). PMID: 29019927    Free PMC article.
Implications of dietary ω-3 and ω-6 polyunsaturated fatty acids in breast cancer.
Oana Zanoaga, Ancuta Jurj, +6 authors, Ioana Berindan-Neagoe.
Exp Ther Med, 2018 Feb 13; 15(2). PMID: 29434704    Free PMC article.
Metabolic and Vascular Effect of the Mediterranean Diet.
Antonino Tuttolomondo, Irene Simonetta, +3 authors, Antonio Pinto.
Int J Mol Sci, 2019 Sep 25; 20(19). PMID: 31547615    Free PMC article.
Review.
Disentangling the Effects of Monounsaturated Fatty Acids from Other Components of a Mediterranean Diet on Serum Metabolite Profiles: A Randomized Fully Controlled Dietary Intervention in Healthy Subjects at Risk of the Metabolic Syndrome.
Charlotte C J R Michielsen, Roland W J Hangelbroek, Edith J M Feskens, Lydia A Afman.
Mol Nutr Food Res, 2019 Feb 07; 63(9). PMID: 30725537    Free PMC article.
Impact of Sample Storage on the NMR Fecal Water Metabolome.
Victoria O'Sullivan, Francisco Madrid-Gambin, +2 authors, Lorraine Brennan.
ACS Omega, 2019 Jan 08; 3(12). PMID: 30613807    Free PMC article.
Paving the Way to Precision Nutrition Through Metabolomics.
Abdellah Tebani, Soumeya Bekri.
Front Nutr, 2019 Apr 27; 6. PMID: 31024923    Free PMC article.
Review.
Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function.
Andy W C Man, Huige Li, Ning Xia.
Oxid Med Cell Longev, 2020 Oct 17; 2020. PMID: 33062134    Free PMC article.
Review.
Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet.
Qi Jin, Alicen Black, +3 authors, Mercedes Sotos-Prieto.
Nutrients, 2019 Jan 24; 11(1). PMID: 30669673    Free PMC article.
Review.