Journal Article
. 2016 May; 5(3):e1074379.
doi: 10.1080/2162402X.2015.1074379.

Targeting immunosuppression by Tregs with monoclonal antibodies against GARP

Stéphanie Liénart 1 Julie Stockis 1 Olivier Dedobbeleer 1 Sophie Lucas 1 
Affiliations
  • PMID: 27141368
  •     10 References
  •     3 citations

Abstract

Reducing Treg function in cancer patients should augment antitumor immune responses. We recently uncovered a mechanism of immunosuppression by human Tregs that implies transmembrane protein GARP and production of active TGF-ß1. We obtained monoclonal antibodies that block this process and could thus serve as a novel approach for cancer immunotherapy.

Keywords: Cancer immunotherapy; TGF-ß1; Tregs; immunosuppression; monoclonal antibodies.

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