BioKDE: Biomedical Knowledge Discovery Engine

Login Signup
Journal Article
Oncoimmunology
. 2016 May; 5(3):e1074379.
doi: 10.1080/2162402X.2015.1074379.

Targeting immunosuppression by Tregs with monoclonal antibodies against GARP

Stéphanie Liénart 1,  Julie Stockis 1,  Olivier Dedobbeleer 1,  Sophie Lucas 1 
Affiliations
  • PMID: 27141368
  •     10 References
  •     3 citations

Abstract

Reducing Treg function in cancer patients should augment antitumor immune responses. We recently uncovered a mechanism of immunosuppression by human Tregs that implies transmembrane protein GARP and production of active TGF-ß1. We obtained monoclonal antibodies that block this process and could thus serve as a novel approach for cancer immunotherapy.

Keywords: Cancer immunotherapy; TGF-ß1; Tregs; immunosuppression; monoclonal antibodies.

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.
Ming O Li, Yisong Y Wan, Richard A Flavell.
 Immunity, 2007 May 08; 26(5). PMID: 17481928
Highly Cited.
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.
Ciriaco A Piccirillo, John J Letterio, +4 authors, Ethan M Shevach.
J Exp Med, 2002 Jul 18; 196(2). PMID: 12119348    Free PMC article.
Highly Cited.
Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.
Julia Cuende, Stéphanie Liénart, +15 authors, Sophie Lucas.
Sci Transl Med, 2015 Apr 24; 7(284). PMID: 25904740
Comparison of stable human Treg and Th clones by transcriptional profiling.
Julie Stockis, Wolfram Fink, +7 authors, Sophie Lucas.
Eur J Immunol, 2009 Feb 19; 39(3). PMID: 19224638
TGF-β activation and function in immunity.
Mark A Travis, Dean Sheppard.
 Annu Rev Immunol, 2013 Dec 10; 32. PMID: 24313777    Free PMC article.
Highly Cited. Review.
Regulatory T cells: mechanisms of differentiation and function.
Steven Z Josefowicz, Li-Fan Lu, Alexander Y Rudensky.
 Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224781    Free PMC article.
Highly Cited. Review.
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Julien C Marie, Denny Liggitt, Alexander Y Rudensky.
 Immunity, 2006 Sep 16; 25(3). PMID: 16973387
Highly Cited.
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Dat Q Tran, John Andersson, +3 authors, Ethan M Shevach.
Proc Natl Acad Sci U S A, 2009 Aug 05; 106(32). PMID: 19651619    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.
Julie Stockis, Didier Colau, Pierre G Coulie, Sophie Lucas.
 Eur J Immunol, 2009 Sep 15; 39(12). PMID: 19750484
B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.
Caroline H Wallace, Bill X Wu, +7 authors, Zihai Li.
JCI Insight, 2018 Apr 06; 3(7). PMID: 29618665    Free PMC article.
Anticancer therapeutics: a brief account on wide refinements.
Fiza Ur Rehman, Mansoor Al-Waeel, Syeda Sohaila Naz, Kifayat Ullah Shah.
 Am J Cancer Res, 2020 Dec 10; 10(11). PMID: 33294257    Free PMC article.
Review.
Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β.
Alessandra Metelli, Bill X Wu, +15 authors, Zihai Li.
Sci Transl Med, 2020 Jan 10; 12(525). PMID: 31915300    Free PMC article.