Journal Article
. 2016 Oct;281(2).
doi: 10.1148/radiol.2016152110.

MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays

Hui Li 1 Yitan Zhu 1 Elizabeth S Burnside 1 Karen Drukker 1 Katherine A Hoadley 1 Cheng Fan 1 Suzanne D Conzen 1 Gary J Whitman 1 Elizabeth J Sutton 1 Jose M Net 1 Marie Ganott 1 Erich Huang 1 Elizabeth A Morris 1 Charles M Perou 1 Yuan Ji 1 Maryellen L Giger 1 
Affiliations
  • PMID: 27144536
  •     37 References
  •     122 citations

Abstract

Purpose To investigate relationships between computer-extracted breast magnetic resonance (MR) imaging phenotypes with multigene assays of MammaPrint, Oncotype DX, and PAM50 to assess the role of radiomics in evaluating the risk of breast cancer recurrence. Materials and Methods Analysis was conducted on an institutional review board-approved retrospective data set of 84 deidentified, multi-institutional breast MR examinations from the National Cancer Institute Cancer Imaging Archive, along with clinical, histopathologic, and genomic data from The Cancer Genome Atlas. The data set of biopsy-proven invasive breast cancers included 74 (88%) ductal, eight (10%) lobular, and two (2%) mixed cancers. Of these, 73 (87%) were estrogen receptor positive, 67 (80%) were progesterone receptor positive, and 19 (23%) were human epidermal growth factor receptor 2 positive. For each case, computerized radiomics of the MR images yielded computer-extracted tumor phenotypes of size, shape, margin morphology, enhancement texture, and kinetic assessment. Regression and receiver operating characteristic analysis were conducted to assess the predictive ability of the MR radiomics features relative to the multigene assay classifications. Results Multiple linear regression analyses demonstrated significant associations (R2 = 0.25-0.32, r = 0.5-0.56, P < .0001) between radiomics signatures and multigene assay recurrence scores. Important radiomics features included tumor size and enhancement texture, which indicated tumor heterogeneity. Use of radiomics in the task of distinguishing between good and poor prognosis yielded area under the receiver operating characteristic curve values of 0.88 (standard error, 0.05), 0.76 (standard error, 0.06), 0.68 (standard error, 0.08), and 0.55 (standard error, 0.09) for MammaPrint, Oncotype DX, PAM50 risk of relapse based on subtype, and PAM50 risk of relapse based on subtype and proliferation, respectively, with all but the latter showing statistical difference from chance. Conclusion Quantitative breast MR imaging radiomics shows promise for image-based phenotyping in assessing the risk of breast cancer recurrence. © RSNA, 2016 Online supplemental material is available for this article.

Volumetric texture analysis of breast lesions on contrast-enhanced magnetic resonance images.
Weijie Chen, Maryellen L Giger, +2 authors, Gillian M Newstead.
Magn Reson Med, 2007 Sep 01; 58(3). PMID: 17763361
Analytical validation of the Oncotype DX genomic diagnostic test for recurrence prognosis and therapeutic response prediction in node-negative, estrogen receptor-positive breast cancer.
Maureen Cronin, Chithra Sangli, +7 authors, Drew Watson.
Clin Chem, 2007 Apr 28; 53(6). PMID: 17463177
Highly Cited.
Reliable and computationally efficient maximum-likelihood estimation of "proper" binormal ROC curves.
Lorenzo L Pesce, Charles E Metz.
Acad Radiol, 2007 Jun 19; 14(7). PMID: 17574132    Free PMC article.
Computerized three-class classification of MRI-based prognostic markers for breast cancer.
Neha Bhooshan, Maryellen Giger, +6 authors, Gillian Newstead.
Phys Med Biol, 2011 Aug 24; 56(18). PMID: 21860079    Free PMC article.
A fuzzy c-means (FCM)-based approach for computerized segmentation of breast lesions in dynamic contrast-enhanced MR images.
Weijie Chen, Maryellen L Giger, Ulrich Bick.
Acad Radiol, 2006 Jan 10; 13(1). PMID: 16399033
Radiogenomic analysis of breast cancer: luminal B molecular subtype is associated with enhancement dynamics at MR imaging.
Maciej A Mazurowski, Jing Zhang, +2 authors, James I Silber.
Radiology, 2014 Jul 17; 273(2). PMID: 25028781
Highly Cited.
Supervised risk predictor of breast cancer based on intrinsic subtypes.
Joel S Parker, Michael Mullins, +17 authors, Philip S Bernard.
J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204204    Free PMC article.
Highly Cited.
The Cancer Imaging Archive (TCIA): maintaining and operating a public information repository.
Kenneth Clark, Bruce Vendt, +9 authors, Fred Prior.
J Digit Imaging, 2013 Jul 26; 26(6). PMID: 23884657    Free PMC article.
Highly Cited.
Anniversary paper: History and status of CAD and quantitative image analysis: the role of Medical Physics and AAPM.
Maryellen L Giger, Heang-Ping Chan, John Boone.
Med Phys, 2009 Jan 30; 35(12). PMID: 19175137    Free PMC article.
Review.
Gene expression profiling predicts clinical outcome of breast cancer.
Laura J van 't Veer, Hongyue Dai, +13 authors, Stephen H Friend.
Nature, 2002 Feb 02; 415(6871). PMID: 11823860
Highly Cited.
Computerized assessment of breast lesion malignancy using DCE-MRI robustness study on two independent clinical datasets from two manufacturers.
Weijie Chen, Maryellen L Giger, +4 authors, Li Lan.
Acad Radiol, 2010 Jun 15; 17(7). PMID: 20540907    Free PMC article.
PAM50 assay and the three-gene model for identifying the major and clinically relevant molecular subtypes of breast cancer.
A Prat, J S Parker, C Fan, C M Perou.
Breast Cancer Res Treat, 2012 Jul 04; 135(1). PMID: 22752290    Free PMC article.
A computerized global MR image feature analysis scheme to assist diagnosis of breast cancer: a preliminary assessment.
Qian Yang, Lihua Li, +2 authors, Bin Zheng.
Eur J Radiol, 2014 Apr 20; 83(7). PMID: 24743001    Free PMC article.
Computerized analysis of breast lesions in three dimensions using dynamic magnetic-resonance imaging.
K G Gilhuijs, M L Giger, U Bick.
Med Phys, 1998 Oct 17; 25(9). PMID: 9775369
Triple-negative invasive breast cancer on dynamic contrast-enhanced and diffusion-weighted MR imaging: comparison with other breast cancer subtypes.
Ji Hyun Youk, Eun Ju Son, +2 authors, Eun-Kyung Kim.
Eur Radiol, 2012 Apr 25; 22(8). PMID: 22527371
"Proper" Binormal ROC Curves: Theory and Maximum-Likelihood Estimation.
Metz, Pan.
J Math Psychol, 1999 May 18; 43(1). PMID: 10069933
Concordance among gene-expression-based predictors for breast cancer.
Cheng Fan, Daniel S Oh, +5 authors, Charles M Perou.
N Engl J Med, 2006 Aug 11; 355(6). PMID: 16899776
Highly Cited.
Pilot study demonstrating potential association between breast cancer image-based risk phenotypes and genomic biomarkers.
Hui Li, Maryellen L Giger, +7 authors, Anna Di Rienzo.
Med Phys, 2014 Mar 07; 41(3). PMID: 24593735    Free PMC article.
Computerized image analysis for identifying triple-negative breast cancers and differentiating them from other molecular subtypes of breast cancer on dynamic contrast-enhanced MR images: a feasibility study.
Shannon C Agner, Mark A Rosen, +6 authors, Anant Madabhushi.
Radiology, 2014 Mar 14; 272(1). PMID: 24620909    Free PMC article.
Experimental pathology and breast cancer genetics: new technologies.
P Osin, J Shipley, +2 authors, B A Gusterson.
Recent Results Cancer Res, 1999 Feb 03; 152. PMID: 9928545
Review.
Recent advances in breast cancer biology.
M A Unger, B L Weber.
Curr Opin Oncol, 2000 Nov 21; 12(6). PMID: 11085450
Review.
The "proper" binormal model: parametric receiver operating characteristic curve estimation with degenerate data.
X Pan, C E Metz.
Acad Radiol, 1997 May 01; 4(5). PMID: 9156236
Computerized interpretation of breast MRI: investigation of enhancement-variance dynamics.
Weijie Chen, Maryellen L Giger, Li Lan, Ulrich Bick.
Med Phys, 2004 Jun 12; 31(5). PMID: 15191295
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
Breast image analysis for risk assessment, detection, diagnosis, and treatment of cancer.
Maryellen L Giger, Nico Karssemeijer, Julia A Schnabel.
Annu Rev Biomed Eng, 2013 May 21; 15. PMID: 23683087
Review.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures.
Cheng Fan, Aleix Prat, +4 authors, Charles M Perou.
BMC Med Genomics, 2011 Jan 11; 4. PMID: 21214954    Free PMC article.
Computerized analysis of digitized mammograms of BRCA1 and BRCA2 gene mutation carriers.
Zhimin Huo, Maryellen L Giger, +5 authors, Shelly A Cummings.
Radiology, 2002 Nov 01; 225(2). PMID: 12409590
Relationships between computer-extracted mammographic texture pattern features and BRCA1/2 mutation status: a cross-sectional study.
Gretchen L Gierach, Hui Li, +14 authors, Maryellen L Giger.
Breast Cancer Res, 2014 Aug 28; 16(4). PMID: 25159706    Free PMC article.
Comprehensive molecular portraits of human breast tumours.
Cancer Genome Atlas Network.
Nature, 2012 Sep 25; 490(7418). PMID: 23000897    Free PMC article.
Highly Cited.
Identification of intrinsic imaging phenotypes for breast cancer tumors: preliminary associations with gene expression profiles.
Ahmed Bilal Ashraf, Dania Daye, +4 authors, Despina Kontos.
Radiology, 2014 Apr 08; 272(2). PMID: 24702725    Free PMC article.
Automatic identification and classification of characteristic kinetic curves of breast lesions on DCE-MRI.
Weijie Chen, Maryellen L Giger, Ulrich Bick, Gillian M Newstead.
Med Phys, 2006 Sep 13; 33(8). PMID: 16964864
A gene-expression signature as a predictor of survival in breast cancer.
Marc J van de Vijver, Yudong D He, +18 authors, René Bernards.
N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681
Highly Cited.
Computerized analysis of mammographic parenchymal patterns on a large clinical dataset of full-field digital mammograms: robustness study with two high-risk datasets.
Hui Li, Maryellen L Giger, +5 authors, Charlene Sennett.
J Digit Imaging, 2012 Jan 17; 25(5). PMID: 22246204    Free PMC article.
Cancerous breast lesions on dynamic contrast-enhanced MR images: computerized characterization for image-based prognostic markers.
Neha Bhooshan, Maryellen L Giger, +3 authors, Gillian M Newstead.
Radiology, 2010 Feb 04; 254(3). PMID: 20123903    Free PMC article.
Update on the potential of computer-aided diagnosis for breast cancer.
Maryellen L Giger.
Future Oncol, 2009 Dec 22; 6(1). PMID: 20021201
Review.
The National Cancer Informatics Program (NCIP) Annotation and Image Markup (AIM) Foundation model.
Pattanasak Mongkolwat, Vladimir Kleper, Skip Talbot, Daniel Rubin.
J Digit Imaging, 2014 Jun 18; 27(6). PMID: 24934452    Free PMC article.
Review.
Molecular subtypes and imaging phenotypes of breast cancer.
Nariya Cho.
Ultrasonography, 2016 Sep 08; 35(4). PMID: 27599892    Free PMC article.
Review.
Associations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRT.
Elizabeth Huynh, Thibaud P Coroller, +7 authors, Hugo J W L Aerts.
PLoS One, 2017 Jan 04; 12(1). PMID: 28046060    Free PMC article.
Unsupervised Clustering of Quantitative Image Phenotypes Reveals Breast Cancer Subtypes with Distinct Prognoses and Molecular Pathways.
Jia Wu, Yi Cui, +5 authors, Ruijiang Li.
Clin Cancer Res, 2017 Jan 12; 23(13). PMID: 28073839    Free PMC article.
Identifying relations between imaging phenotypes and molecular subtypes of breast cancer: Model discovery and external validation.
Jia Wu, Xiaoli Sun, +5 authors, Ruijiang Li.
J Magn Reson Imaging, 2017 Feb 09; 46(4). PMID: 28177554    Free PMC article.
Computer-aided heterogeneity analysis in breast MR imaging assessment of ductal carcinoma in situ: Correlating histologic grade and receptor status.
Shinn-Huey S Chou, Eva C Gombos, +2 authors, Jagadeesan Jayender.
J Magn Reson Imaging, 2017 Apr 04; 46(6). PMID: 28371110    Free PMC article.
Intratumoral and peritumoral radiomics for the pretreatment prediction of pathological complete response to neoadjuvant chemotherapy based on breast DCE-MRI.
Nathaniel M Braman, Maryam Etesami, +5 authors, Anant Madabhushi.
Breast Cancer Res, 2017 May 20; 19(1). PMID: 28521821    Free PMC article.
Highly Cited.
Apparent diffusion coefficient in estrogen receptor-positive and lymph node-negative invasive breast cancers at 3.0T DW-MRI: A potential predictor for an oncotype Dx test recurrence score.
Sunitha B Thakur, Manuela Durando, +5 authors, Elizabeth A Morris.
J Magn Reson Imaging, 2017 Jun 24; 47(2). PMID: 28640531    Free PMC article.
Heterogeneous Enhancement Patterns of Tumor-adjacent Parenchyma at MR Imaging Are Associated with Dysregulated Signaling Pathways and Poor Survival in Breast Cancer.
Jia Wu, Bailiang Li, +6 authors, Ruijiang Li.
Radiology, 2017 Jul 15; 285(2). PMID: 28708462    Free PMC article.
Defining the biological basis of radiomic phenotypes in lung cancer.
Patrick Grossmann, Olya Stringfield, +8 authors, Hugo Jwl Aerts.
Elife, 2017 Jul 22; 6. PMID: 28731408    Free PMC article.
Highly Cited.
Preoperative prediction of sentinel lymph node metastasis in breast cancer based on radiomics of T2-weighted fat-suppression and diffusion-weighted MRI.
Yuhao Dong, Qianjin Feng, +12 authors, Shuixing Zhang.
Eur Radiol, 2017 Aug 23; 28(2). PMID: 28828635
Highly Cited.
Radiomics: the bridge between medical imaging and personalized medicine.
Philippe Lambin, Ralph T H Leijenaar, +17 authors, Sean Walsh.
Nat Rev Clin Oncol, 2017 Oct 05; 14(12). PMID: 28975929
Highly Cited. Review.
Advanced nasopharyngeal carcinoma: pre-treatment prediction of progression based on multi-parametric MRI radiomics.
Bin Zhang, Fusheng Ouyang, +5 authors, Shuixing Zhang.
Oncotarget, 2017 Oct 27; 8(42). PMID: 29069802    Free PMC article.
Exploration and validation of radiomics signature as an independent prognostic biomarker in stage III-IVb nasopharyngeal carcinoma.
Fu-Sheng Ouyang, Bao-Liang Guo, +6 authors, Qiu-Gen Hu.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088830    Free PMC article.
Background, current role, and potential applications of radiogenomics.
Katja Pinker, Fuki Shitano, +6 authors, Elizabeth A Morris.
J Magn Reson Imaging, 2017 Nov 03; 47(3). PMID: 29095543    Free PMC article.
Highly Cited. Review.
A predictive model for distinguishing radiation necrosis from tumour progression after gamma knife radiosurgery based on radiomic features from MR images.
Zijian Zhang, Jinzhong Yang, +12 authors, Jing Li.
Eur Radiol, 2017 Nov 28; 28(6). PMID: 29178031    Free PMC article.
Diffusion-weighted MRI characteristics associated with prognostic pathological factors and recurrence risk in invasive ER+/HER2- breast cancers.
Nita Amornsiripanitch, Vicky T Nguyen, +4 authors, Savannah C Partridge.
J Magn Reson Imaging, 2017 Nov 28; 48(1). PMID: 29178616    Free PMC article.
Clinical role of breast MRI now and going forward.
D Leithner, G J Wengert, +4 authors, K Pinker.
Clin Radiol, 2017 Dec 13; 73(8). PMID: 29229179    Free PMC article.
Review.
Radiomic Features Are Superior to Conventional Quantitative Computed Tomographic Metrics to Identify Coronary Plaques With Napkin-Ring Sign.
Márton Kolossváry, Júlia Karády, +4 authors, Pál Maurovich-Horvat.
Circ Cardiovasc Imaging, 2017 Dec 14; 10(12). PMID: 29233836    Free PMC article.
Radiomics and radiogenomics for precision radiotherapy.
Jia Wu, Khin Khin Tha, Lei Xing, Ruijiang Li.
J Radiat Res, 2018 Feb 01; 59(suppl_1). PMID: 29385618    Free PMC article.
A study of association of Oncotype DX recurrence score with DCE-MRI characteristics using multivariate machine learning models.
Ashirbani Saha, Michael R Harowicz, Weiyao Wang, Maciej A Mazurowski.
J Cancer Res Clin Oncol, 2018 Feb 11; 144(5). PMID: 29427210    Free PMC article.
Radiomic signature as a diagnostic factor for histologic subtype classification of non-small cell lung cancer.
Xinzhong Zhu, Di Dong, +8 authors, Jie Tian.
Eur Radiol, 2018 Feb 17; 28(7). PMID: 29450713
Highly Cited.
Deep learning with convolutional neural network in radiology.
Koichiro Yasaka, Hiroyuki Akai, +2 authors, Osamu Abe.
Jpn J Radiol, 2018 Mar 03; 36(4). PMID: 29498017
Review.
High-dimensional regression analysis links magnetic resonance imaging features and protein expression and signaling pathway alterations in breast invasive carcinoma.
Michael Lehrer, Anindya Bhadra, +14 authors, TCGA Breast Phenotype Research Group.
Oncoscience, 2018 Mar 21; 5(1-2). PMID: 29556516    Free PMC article.
DCE-MRI Pharmacokinetic-Based Phenotyping of Invasive Ductal Carcinoma: A Radiomic Study for Prediction of Histological Outcomes.
Serena Monti, Marco Aiello, +6 authors, Marco Salvatore.
Contrast Media Mol Imaging, 2018 Mar 28; 2018. PMID: 29581709    Free PMC article.
Radiogenomics analysis identifies correlations of digital mammography with clinical molecular signatures in breast cancer.
Jose-Gerardo Tamez-Peña, Juan-Andrés Rodriguez-Rojas, +6 authors, Victor Treviño.
PLoS One, 2018 Mar 30; 13(3). PMID: 29596496    Free PMC article.
Breast MRI radiomics: comparison of computer- and human-extracted imaging phenotypes.
Elizabeth J Sutton, Erich P Huang, +11 authors, TCGA group.
Eur Radiol Exp, 2017 Jan 01; 1(1). PMID: 29708200    Free PMC article.
Intratumoral Spatial Heterogeneity at Perfusion MR Imaging Predicts Recurrence-free Survival in Locally Advanced Breast Cancer Treated with Neoadjuvant Chemotherapy.
Jia Wu, Guohong Cao, +6 authors, Ruijiang Li.
Radiology, 2018 May 02; 288(1). PMID: 29714680    Free PMC article.
Highly Cited.
Non-invasive tumor genotyping using radiogenomic biomarkers, a systematic review and oncology-wide pathway analysis.
Robin W Jansen, Paul van Amstel, +10 authors, Marcus C de Jong.
Oncotarget, 2018 May 08; 9(28). PMID: 29732009    Free PMC article.
Review.
Computer-aided diagnosis with radiogenomics: analysis of the relationship between genotype and morphological changes of the brain magnetic resonance images.
Chiharu Kai, Yoshikazu Uchiyama, +2 authors, Kunio Doi.
Radiol Phys Technol, 2018 May 12; 11(3). PMID: 29750429
Imaging and the completion of the omics paradigm in breast cancer.
D Leithner, J V Horvat, +5 authors, K Pinker.
Radiologe, 2018 Jun 28; 58(Suppl 1). PMID: 29947931    Free PMC article.
Review.
Lesion location implemented magnetic resonance imaging radiomics for predicting IDH and TERT promoter mutations in grade II/III gliomas.
Hideyuki Arita, Manabu Kinoshita, +21 authors, Yonehiro Kanemura.
Sci Rep, 2018 Aug 08; 8(1). PMID: 30082856    Free PMC article.
Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis.
Shih-Ying Huang, Benjamin L Franc, +11 authors, Youngho Seo.
NPJ Breast Cancer, 2018 Aug 23; 4. PMID: 30131973    Free PMC article.
Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings.
Gregory Penzias, Asha Singanamalli, +13 authors, Anant Madabhushi.
PLoS One, 2018 Sep 01; 13(8). PMID: 30169514    Free PMC article.
Magnetic resonance imaging and molecular features associated with tumor-infiltrating lymphocytes in breast cancer.
Jia Wu, Xuejie Li, +4 authors, Ruijiang Li.
Breast Cancer Res, 2018 Sep 05; 20(1). PMID: 30176944    Free PMC article.
A biomarker basing on radiomics for the prediction of overall survival in non-small cell lung cancer patients.
Bo He, Wei Zhao, +4 authors, Wei Zhao.
Respir Res, 2018 Oct 12; 19(1). PMID: 30305102    Free PMC article.
Application of Radiomics and Decision Support Systems for Breast MR Differential Diagnosis.
Ioannis Tsougos, Alexandros Vamvakas, +2 authors, Katerina Vassiou.
Comput Math Methods Med, 2018 Oct 23; 2018. PMID: 30344618    Free PMC article.
Review.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Review.
A radiomic signature as a non-invasive predictor of progression-free survival in patients with lower-grade gliomas.
Xing Liu, Yiming Li, +9 authors, Yinyan Wang.
Neuroimage Clin, 2018 Oct 27; 20. PMID: 30366279    Free PMC article.
A New Challenge for Radiologists: Radiomics in Breast Cancer.
Paola Crivelli, Roberta Eufrasia Ledda, +3 authors, Maurizio Conti.
Biomed Res Int, 2018 Nov 08; 2018. PMID: 30402486    Free PMC article.
Review.
Classification of the glioma grading using radiomics analysis.
Hwan-Ho Cho, Seung-Hak Lee, Jonghoon Kim, Hyunjin Park.
PeerJ, 2018 Dec 01; 6. PMID: 30498643    Free PMC article.
Imaging-Genomic Study of Head and Neck Squamous Cell Carcinoma: Associations Between Radiomic Phenotypes and Genomic Mechanisms via Integration of The Cancer Genome Atlas and The Cancer Imaging Archive.
Yitan Zhu, Abdallah S R Mohamed, +16 authors, Clifton D Fuller.
JCO Clin Cancer Inform, 2019 Feb 08; 3. PMID: 30730765    Free PMC article.
Preoperative Differentiation of Uterine Sarcoma from Leiomyoma: Comparison of Three Models Based on Different Segmentation Volumes Using Radiomics.
Huihui Xie, Xiaodong Zhang, +2 authors, Xiaoying Wang.
Mol Imaging Biol, 2019 Mar 10; 21(6). PMID: 30850967
Precision diagnostics based on machine learning-derived imaging signatures.
Christos Davatzikos, Aristeidis Sotiras, +7 authors, Despina Kontos.
Magn Reson Imaging, 2019 May 10; 64. PMID: 31071473    Free PMC article.
Review.
Radiomics-based prediction of microsatellite instability in colorectal cancer at initial computed tomography evaluation.
Jennifer S Golia Pernicka, Johan Gagniere, +11 authors, Marc J Gollub.
Abdom Radiol (NY), 2019 Jun 30; 44(11). PMID: 31250180    Free PMC article.
Diffusion-weighted MRI of estrogen receptor-positive, HER2-negative, node-negative breast cancer: association between intratumoral heterogeneity and recurrence risk.
Jin You Kim, Jin Joo Kim, +8 authors, Robert Grimm.
Eur Radiol, 2019 Aug 07; 30(1). PMID: 31385051
Artificial Intelligence for Mammography and Digital Breast Tomosynthesis: Current Concepts and Future Perspectives.
Krzysztof J Geras, Ritse M Mann, Linda Moy.
Radiology, 2019 Sep 25; 293(2). PMID: 31549948    Free PMC article.
Review.
Radiomics-based predictive risk score: A scoring system for preoperatively predicting risk of lymph node metastasis in patients with resectable non-small cell lung cancer.
Lan He, Yanqi Huang, +3 authors, Zaiyi Liu.
Chin J Cancer Res, 2019 Oct 01; 31(4). PMID: 31564807    Free PMC article.
Tumour heterogeneity revealed by unsupervised decomposition of dynamic contrast-enhanced magnetic resonance imaging is associated with underlying gene expression patterns and poor survival in breast cancer patients.
Ming Fan, Pingping Xia, +4 authors, Lihua Li.
Breast Cancer Res, 2019 Oct 19; 21(1). PMID: 31623683    Free PMC article.
Molecular Subtypes Recognition of Breast Cancer in Dynamic Contrast-Enhanced Breast Magnetic Resonance Imaging Phenotypes from Radiomics Data.
Wei Li, Kun Yu, Chaolu Feng, Dazhe Zhao.
Comput Math Methods Med, 2019 Dec 13; 2019. PMID: 31827586    Free PMC article.
Radiomics in stratification of pancreatic cystic lesions: Machine learning in action.
Vipin Dalal, Joseph Carmicheal, +3 authors, Surinder K Batra.
Cancer Lett, 2019 Oct 21; 469. PMID: 31629933    Free PMC article.
Review.
TCGA-TCIA Impact on Radiogenomics Cancer Research: A Systematic Review.
Mario Zanfardino, Katia Pane, +2 authors, Monica Franzese.
Int J Mol Sci, 2019 Dec 05; 20(23). PMID: 31795520    Free PMC article.
Systematic Review.
MRI-derived radiomics: methodology and clinical applications in the field of pelvic oncology.
Ulrike Schick, François Lucia, +6 authors, Mathieu Hatt.
Br J Radiol, 2019 Sep 21; 92(1104). PMID: 31538516    Free PMC article.
Review.
Quantitative MRI Biomarkers of Stereotactic Radiotherapy Outcome in Brain Metastasis.
Elham Karami, Hany Soliman, +9 authors, Ali Sadeghi-Naini.
Sci Rep, 2019 Dec 29; 9(1). PMID: 31882597    Free PMC article.
A New Application of Multimodality Radiomics Improves Diagnostic Accuracy of Nonpalpable Breast Lesions in Patients with Microcalcifications-Only in Mammography.
Shujun Chen, Xiaojun Guan, +6 authors, Feng Shao.
Med Sci Monit, 2019 Dec 21; 25. PMID: 31860635    Free PMC article.
Prediction of IDH and TERT promoter mutations in low-grade glioma from magnetic resonance images using a convolutional neural network.
Ryohei Fukuma, Takufumi Yanagisawa, +25 authors, Haruhiko Kishima.
Sci Rep, 2020 Jan 01; 9(1). PMID: 31889117    Free PMC article.
Quality of science and reporting of radiomics in oncologic studies: room for improvement according to radiomics quality score and TRIPOD statement.
Ji Eun Park, Donghyun Kim, +5 authors, Jeong Hoon Kim.
Eur Radiol, 2019 Jul 28; 30(1). PMID: 31350588
Combining molecular and imaging metrics in cancer: radiogenomics.
Roberto Lo Gullo, Isaac Daimiel, Elizabeth A Morris, Katja Pinker.
Insights Imaging, 2020 Jan 05; 11(1). PMID: 31901171    Free PMC article.
Review.
Evaluation of the predictive ability of ultrasound-based assessment of breast cancer using BI-RADS natural language reporting against commercial transcriptome-based tests.
Neema Jamshidii, Jason Chang, +3 authors, Michael D Kuo.
PLoS One, 2020 Jan 11; 15(1). PMID: 31923222    Free PMC article.
Manual and semiautomatic segmentation of bone sarcomas on MRI have high similarity.
F C F Dionísio, L S Oliveira, +4 authors, M H Nogueira-Barbosa.
Braz J Med Biol Res, 2020 Feb 06; 53(2). PMID: 32022102    Free PMC article.
Imaging Phenotypes of Breast Cancer Heterogeneity in Preoperative Breast Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) Scans Predict 10-Year Recurrence.
Rhea D Chitalia, Jennifer Rowland, +7 authors, Despina Kontos.
Clin Cancer Res, 2019 Nov 17; 26(4). PMID: 31732521    Free PMC article.
Lymph Node Imaging in Patients with Primary Breast Cancer: Concurrent Diagnostic Tools.
Maria Adele Marino, Daly Avendano, +2 authors, Katja Pinker.
Oncologist, 2020 Feb 12; 25(2). PMID: 32043792    Free PMC article.
Review.
Three-dimensional radiomics of triple-negative breast cancer: Prediction of systemic recurrence.
Jieun Koh, Eunjung Lee, +5 authors, Hee Jung Moon.
Sci Rep, 2020 Feb 23; 10(1). PMID: 32076078    Free PMC article.
Contrast-Enhanced Mammography and Radiomics Analysis for Noninvasive Breast Cancer Characterization: Initial Results.
Maria Adele Marino, Katja Pinker, +4 authors, Maxine Jochelson.
Mol Imaging Biol, 2019 Aug 30; 22(3). PMID: 31463822    Free PMC article.
Assessment of the Spatial Heterogeneity of Breast Cancers: Associations Between Computed Tomography and Immunohistochemistry.
David K Woolf, Sonia P Li, +10 authors, Vicky Goh.
Biomark Cancer, 2019 Jun 19; 11. PMID: 31210736    Free PMC article.
Combining Multiple Magnetic Resonance Imaging Sequences Provides Independent Reproducible Radiomics Features.
A Lecler, L Duron, +7 authors, L S Fournier.
Sci Rep, 2019 Feb 16; 9(1). PMID: 30765732    Free PMC article.
The complexity of tumor shape, spiculatedness, correlates with tumor radiomic shape features.
Elaine Johanna Limkin, Sylvain Reuzé, +6 authors, Charlotte Robert.
Sci Rep, 2019 Mar 15; 9(1). PMID: 30867443    Free PMC article.
Association Between Radiomics Signature and Disease-Free Survival in Conventional Papillary Thyroid Carcinoma.
Vivian Y Park, Kyunghwa Han, +4 authors, Jin Young Kwak.
Sci Rep, 2019 Mar 16; 9(1). PMID: 30872763    Free PMC article.
Automated volumetric radiomic analysis of breast cancer vascularization improves survival prediction in primary breast cancer.
Matthias Dietzel, Rüdiger Schulz-Wendtland, +7 authors, Pascal A T Baltzer.
Sci Rep, 2020 Mar 01; 10(1). PMID: 32111898    Free PMC article.
A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models.
Pascal O Zinn, Sanjay K Singh, +17 authors, Rivka R Colen.
Clin Cancer Res, 2018 Jul 29; 24(24). PMID: 30054278    Free PMC article.
Radiomics in RayPlus: a Web-Based Tool for Texture Analysis in Medical Images.
Rong Yuan, Shuyue Shi, Junhui Chen, Guanxun Cheng.
J Digit Imaging, 2018 Oct 24; 32(2). PMID: 30350006    Free PMC article.
Combined Benefit of Quantitative Three-Compartment Breast Image Analysis and Mammography Radiomics in the Classification of Breast Masses in a Clinical Data Set.
Karen Drukker, Maryellen L Giger, +9 authors, John Shepherd.
Radiology, 2018 Dec 12; 290(3). PMID: 30526359    Free PMC article.
NCTN Assessment on Current Applications of Radiomics in Oncology.
Ke Nie, Hania Al-Hallaq, +15 authors, Issam El Naqa.
Int J Radiat Oncol Biol Phys, 2019 Feb 04; 104(2). PMID: 30711529    Free PMC article.
Review.
Artificial intelligence in cancer imaging: Clinical challenges and applications.
Wenya Linda Bi, Ahmed Hosny, +16 authors, Hugo J W L Aerts.
CA Cancer J Clin, 2019 Feb 06; 69(2). PMID: 30720861    Free PMC article.
Highly Cited. Review.
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers.
S Trebeschi, S G Drago, +15 authors, H J W L Aerts.
Ann Oncol, 2019 Mar 22; 30(6). PMID: 30895304    Free PMC article.
Highly Cited.
Artificial Intelligence: reshaping the practice of radiological sciences in the 21st century.
Issam El Naqa, Masoom A Haider, Maryellen L Giger, Randall K Ten Haken.
Br J Radiol, 2020 Jan 23; 93(1106). PMID: 31965813    Free PMC article.
Review.
Role of texture analysis in breast MRI as a cancer biomarker: A review.
Rhea D Chitalia, Despina Kontos.
J Magn Reson Imaging, 2018 Nov 06; 49(4). PMID: 30390383    Free PMC article.
Review.
The Impact of Normalization Approaches to Automatically Detect Radiogenomic Phenotypes Characterizing Breast Cancer Receptors Status.
Rossana Castaldo, Katia Pane, +2 authors, Monica Franzese.
Cancers (Basel), 2020 Feb 28; 12(2). PMID: 32102334    Free PMC article.
Will traditional biopsy be substituted by radiomics and liquid biopsy for breast cancer diagnosis and characterisation?
Filippo Pesapane, Matteo Basilio Suter, +7 authors, Enrico Cassano.
Med Oncol, 2020 Mar 18; 37(4). PMID: 32180032
Review.
Machine learning in breast MRI.
Beatriu Reig, Laura Heacock, Krzysztof J Geras, Linda Moy.
J Magn Reson Imaging, 2019 Jul 06; 52(4). PMID: 31276247    Free PMC article.
Review.
Radiomic Signatures Derived from Diffusion-Weighted Imaging for the Assessment of Breast Cancer Receptor Status and Molecular Subtypes.
Doris Leithner, Blanca Bernard-Davila, +9 authors, Katja Pinker.
Mol Imaging Biol, 2019 Jun 19; 22(2). PMID: 31209778    Free PMC article.
Preoperative prediction of cavernous sinus invasion by pituitary adenomas using a radiomics method based on magnetic resonance images.
Jianxing Niu, Shuaitong Zhang, +5 authors, Wang Jia.
Eur Radiol, 2018 Sep 27; 29(3). PMID: 30255254    Free PMC article.
Pretreatment prediction of immunoscore in hepatocellular cancer: a radiomics-based clinical model based on Gd-EOB-DTPA-enhanced MRI imaging.
Shuling Chen, Shiting Feng, +11 authors, Ming Kuang.
Eur Radiol, 2019 Jan 23; 29(8). PMID: 30666445
Radiomics on multi-modalities MR sequences can subtype patients with non-metastatic nasopharyngeal carcinoma (NPC) into distinct survival subgroups.
En-Hong Zhuo, Wei-Jing Zhang, +8 authors, Hong-Min Cai.
Eur Radiol, 2019 Mar 16; 29(10). PMID: 30874880
Adaptive statistical iterative reconstruction (ASIR) affects CT radiomics quantification in primary colorectal cancer.
Davide Prezzi, Katarzyna Owczarczyk, +4 authors, Vicky Goh.
Eur Radiol, 2019 Mar 20; 29(10). PMID: 30887205    Free PMC article.
Radiomics Study of Thyroid Ultrasound for Predicting BRAF Mutation in Papillary Thyroid Carcinoma: Preliminary Results.
M-R Kwon, J H Shin, +3 authors, K W Park.
AJNR Am J Neuroradiol, 2020 Apr 11; 41(4). PMID: 32273326    Free PMC article.
Multi-Omics Integration Reveals a Competitive Endogenous RNAs Network for the Identification of Progression Biomarkers and the Stratification of Patients Diagnosed With Nephroblastoma.
Jingbo Wang, Yuan Wang, +3 authors, Furong Li.
Front Oncol, 2020 Apr 23; 10. PMID: 32318341    Free PMC article.
Association of distant recurrence-free survival with algorithmically extracted MRI characteristics in breast cancer.
Maciej A Mazurowski, Ashirbani Saha, +3 authors, P Kelly Marcom.
J Magn Reson Imaging, 2019 Jan 24; 49(7). PMID: 30672045    Free PMC article.
Correlation Between Mammographic Radiomics Features and the Level of Tumor-Infiltrating Lymphocytes in Patients With Triple-Negative Breast Cancer.
Hongwei Yu, Xianqi Meng, +10 authors, Jian Yang.
Front Oncol, 2020 May 01; 10. PMID: 32351879    Free PMC article.
Differentiation of Pelvic Osteosarcoma and Ewing Sarcoma Using Radiomic Analysis Based on T2-Weighted Images and Contrast-Enhanced T1-Weighted Images.
Yi Dai, Ping Yin, +4 authors, Nan Hong.
Biomed Res Int, 2020 May 29; 2020. PMID: 32462033    Free PMC article.
Digital Analysis in Breast Imaging.
Giovanna Negrão de Figueiredo, Michael Ingrisch, Eva Maria Fallenberg.
Breast Care (Basel), 2019 Jul 19; 14(3). PMID: 31316312    Free PMC article.
Review.
Accurate Preoperative Distinction of Intracranial Hemangiopericytoma From Meningioma Using a Multihabitat and Multisequence-Based Radiomics Diagnostic Technique.
Jingwei Wei, Lianwang Li, +7 authors, Dabiao Zhou.
Front Oncol, 2020 Jun 09; 10. PMID: 32509567    Free PMC article.
Magnetic resonance imaging semantic and quantitative features analyses: an additional diagnostic tool for breast phyllodes tumors.
Wenjuan Ma, Xinpeng Guo, +8 authors, Chao Zhang.
Am J Transl Res, 2020 Jun 09; 12(5). PMID: 32509202    Free PMC article.
Radiogenomics of magnetic resonance imaging and a new multi-gene classifier for predicting recurrence prognosis in estrogen receptor-positive breast cancer: A preliminary study.
Yukiko Tokuda, Masahiro Yanagawa, +3 authors, Noriyuki Tomiyama.
Medicine (Baltimore), 2020 Apr 22; 99(16). PMID: 32311939    Free PMC article.
Multiparametric Modelling of Survival in Pancreatic Ductal Adenocarcinoma Using Clinical, Histomorphological, Genetic and Image-Derived Parameters.
Georgios A Kaissis, Friederike Jungmann, +11 authors, Rickmer F Braren.
J Clin Med, 2020 Apr 30; 9(5). PMID: 32344944    Free PMC article.
Synchronous Breast Cancer: Phenotypic Similarities on MRI.
Hui Wang, Bas H M van der Velden, +3 authors, Kenneth G A Gilhuijs.
J Magn Reson Imaging, 2019 Dec 20; 51(6). PMID: 31854487    Free PMC article.
Outcomes assessment in intrahepatic cholangiocarcinoma using qualitative and quantitative imaging features.
Michael J King, Stefanie Hectors, +6 authors, Sara Lewis.
Cancer Imaging, 2020 Jul 06; 20(1). PMID: 32620153    Free PMC article.
Impact of mRNA-Assessed Molecular Subtype Conversion, Intact and Apoptotic Circulating Tumor Cells on Survival of Metastatic Breast Cancer Patients: Proof of Principle.
Stefan Stefanovic, Thomas M Deutsch, +9 authors, Markus Wallwiener.
Diagnostics (Basel), 2020 Jun 10; 10(6). PMID: 32512707    Free PMC article.
Development of a Novel, Multi-Parametric, MRI-Based Radiomic Nomogram for Differentiating Between Clinically Significant and Insignificant Prostate Cancer.
Yongsheng Zhang, Wen Chen, +5 authors, Maosheng Xu.
Front Oncol, 2020 Jul 23; 10. PMID: 32695660    Free PMC article.
Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging.
Maria Adele Marino, Doris Leithner, +4 authors, Maxine S Jochelson.
Diagnostics (Basel), 2020 Jul 28; 10(7). PMID: 32708512    Free PMC article.
Relationships Between Human-Extracted MRI Tumor Phenotypes of Breast Cancer and Clinical Prognostic Indicators Including Receptor Status and Molecular Subtype.
Jose M Net, Gary J Whitman, +7 authors, Arvind Rao.
Curr Probl Diagn Radiol, 2018 Oct 03; 48(5). PMID: 30270031    Free PMC article.
Correlation Between Hippocampus MRI Radiomic Features and Resting-State Intrahippocampal Functional Connectivity in Alzheimer's Disease.
Qi Feng, Mei Wang, +6 authors, Zhongxiang Ding.
Front Neurosci, 2019 May 28; 13. PMID: 31133781    Free PMC article.
Radiomic Nomogram: Pretreatment Evaluation of Local Recurrence in Nasopharyngeal Carcinoma based on MR Imaging.
Lu Zhang, Hongyu Zhou, +13 authors, Shuixing Zhang.
J Cancer, 2019 Aug 16; 10(18). PMID: 31413740    Free PMC article.
Could Ultrasound-Based Radiomics Noninvasively Predict Axillary Lymph Node Metastasis in Breast Cancer?
Xiaoying Qiu, Yongluo Jiang, +3 authors, Tian'an Jiang.
J Ultrasound Med, 2020 Apr 25; 39(10). PMID: 32329142    Free PMC article.
Comparison of patient stratification by computed tomography radiomics and hypoxia positron emission tomography in head-and-neck cancer radiotherapy.
Jairo A Socarrás Fernández, David Mönnich, +10 authors, Daniela Thorwarth.
Phys Imaging Radiat Oncol, 2020 Oct 13; 15. PMID: 33043157    Free PMC article.
Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer.
Ming Fan, Pingping Xia, +2 authors, Lihua Li.
Nat Commun, 2020 Sep 27; 11(1). PMID: 32978398    Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma.
Soumen Khatua, Laurence J N Cooper, +18 authors, Vidya Gopalakrishnan.
Neuro Oncol, 2020 Mar 11; 22(8). PMID: 32152626    Free PMC article.
Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer.
Archya Dasgupta, Stephen Brade, +14 authors, Gregory J Czarnota.
Oncotarget, 2020 Nov 05; 11(42). PMID: 33144919    Free PMC article.
Prediction of the clinicopathological subtypes of breast cancer using a fisher discriminant analysis model based on radiomic features of diffusion-weighted MRI.
Ming Ni, Xiaoming Zhou, +4 authors, Zhiming Li.
BMC Cancer, 2020 Nov 11; 20(1). PMID: 33167903    Free PMC article.
Role of dynamic contrast-enhanced MRI in evaluating the association between contralateral parenchymal enhancement and survival outcome in ER-positive, HER2-negative, node-negative invasive breast cancer.
Gi Won Shin, Yang Zhang, +5 authors, Vivian Youngjean Park.
J Magn Reson Imaging, 2018 May 08; 48(6). PMID: 29734483    Free PMC article.
[Radiomics: Big Data Instead of Biopsies in the Future?]
Kathrin Scheckenbach.
Laryngorhinootologie, 2018 Jun 16; 97(S 01). PMID: 29905355    Free PMC article.
Review.
A machine learning approach to radiogenomics of breast cancer: a study of 922 subjects and 529 DCE-MRI features.
Ashirbani Saha, Michael R Harowicz, +4 authors, Maciej A Mazurowski.
Br J Cancer, 2018 Jul 24; 119(4). PMID: 30033447    Free PMC article.
Development and validation of a magnetic resonance imaging-based model for the prediction of distant metastasis before initial treatment of nasopharyngeal carcinoma: A retrospective cohort study.
Lu Zhang, Di Dong, +12 authors, Shuixing Zhang.
EBioMedicine, 2019 Jan 16; 40. PMID: 30642750    Free PMC article.
Pretreatment MRI radiomics analysis allows for reliable prediction of local recurrence in non-metastatic T4 nasopharyngeal carcinoma.
Lu-Lu Zhang, Meng-Yao Huang, +12 authors, Ying Sun.
EBioMedicine, 2019 Apr 01; 42. PMID: 30928358    Free PMC article.
Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling.
Albert C Yeh, Hui Li, +14 authors, Olufunmilayo I Olopade.
Cancer Imaging, 2019 Jul 17; 19(1). PMID: 31307537    Free PMC article.
MR image-based radiomics to differentiate type Ι and type ΙΙ epithelial ovarian cancers.
Junming Jian, Yong'ai Li, +16 authors, Jinwei Qiang.
Eur Radiol, 2020 Aug 04; 31(1). PMID: 32743768
Identifying Cross-Scale Associations between Radiomic and Pathomic Signatures of Non-Small Cell Lung Cancer Subtypes: Preliminary Results.
Charlems Alvarez-Jimenez, Alvaro A Sandino, +3 authors, Eduardo Romero.
Cancers (Basel), 2020 Dec 11; 12(12). PMID: 33297357    Free PMC article.
Radiomic analysis of HTR-DCE MR sequences improves diagnostic performance compared to BI-RADS analysis of breast MR lesions.
Saskia Vande Perre, Loïc Duron, +5 authors, Isabelle Thomassin-Naggara.
Eur Radiol, 2021 Jan 07;. PMID: 33404696
Improving prognostic performance in resectable pancreatic ductal adenocarcinoma using radiomics and deep learning features fusion in CT images.
Yucheng Zhang, Edrise M Lobo-Mueller, +3 authors, Farzad Khalvati.
Sci Rep, 2021 Jan 16; 11(1). PMID: 33446870    Free PMC article.
[Multimodal, multiparametric and genetic breast imaging].
Roberto LoGullo, Joao Horvat, Jeffrey Reiner, Katja Pinker.
Radiologe, 2021 Jan 20; 61(2). PMID: 33464404
Review.
The rate of breast fibroglandular enhancement during dynamic contrast-enhanced MRI reflects response to neoadjuvant therapy.
John Virostko, Garrett Kuketz, +7 authors, Thomas E Yankeelov.
Eur J Radiol, 2021 Jan 18; 136. PMID: 33454460    Free PMC article.