. 2016 May; 28(8):401-9.
doi: 10.1093/intimm/dxw025.

Roles of regulatory T cells in cancer immunity

Yoshiko Takeuchi 1 Hiroyoshi Nishikawa 2 
  • PMID: 27160722
  •     103 References
  •     187 citations


CD4(+) regulatory T cells (Tregs) expressing the transcription factor FoxP3 are highly immune suppressive and play central roles in the maintenance of self-tolerance and immune homeostasis, yet in malignant tumors they promote tumor progression by suppressing effective antitumor immunity. Indeed, higher infiltration by Tregs is observed in tumor tissues, and their depletion augments antitumor immune responses in animal models. Additionally, increased numbers of Tregs and, in particular, decreased ratios of CD8(+) T cells to Tregs among tumor-infiltrating lymphocytes are correlated with poor prognosis in various types of human cancers. The recent success of cancer immunotherapy represented by immune checkpoint blockade has provided a new insight in cancer treatment, yet more than half of the treated patients did not experience clinical benefits. Identifying biomarkers that predict clinical responses and developing novel immunotherapies are therefore urgently required. Cancer patients whose tumors contain a large number of neoantigens stemming from gene mutations, which have not been previously recognized by the immune system, provoke strong antitumor T-cell responses associated with clinical responses following immune checkpoint blockade, depending on the resistance to Treg-mediated suppression. Thus, integration of a strategy restricting Treg-mediated immune suppression may expand the therapeutic spectrum of cancer immunotherapy towards patients with a lower number of neoantigens. In this review, we address the current understanding of Treg-mediated immune suppressive mechanisms in cancer, the involvement of Tregs in cancer immunotherapy, and strategies for effective and tolerable Treg-targeted therapy.

Keywords: Treg-targeted therapy; immune checkpoint inhibitors; immune suppression.

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Julie R Brahmer, Scott S Tykodi, +23 authors, Jon M Wigginton.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658128    Free PMC article.
Highly Cited.
OX40 is a potent immune-stimulating target in late-stage cancer patients.
Brendan D Curti, Magdalena Kovacsovics-Bankowski, +20 authors, Andrew D Weinberg.
Cancer Res, 2013 Nov 02; 73(24). PMID: 24177180    Free PMC article.
Highly Cited.
Introduction: Cancer Immunology Special Issue-Immunopathology.
Yutaka Kawakami.
Int Immunol, 2016 Jul 28; 28(8). PMID: 27450690    Free PMC article.
Monitoring of the Immune Dysfunction in Cancer Patients.
Saskia J A M Santegoets, Marij J P Welters, Sjoerd H van der Burg.
Vaccines (Basel), 2016 Sep 07; 4(3). PMID: 27598210    Free PMC article.
Immune checkpoint and inflammation as therapeutic targets in pancreatic carcinoma.
Shiro Kimbara, Shunsuke Kondo.
World J Gastroenterol, 2016 Sep 28; 22(33). PMID: 27672267    Free PMC article.
Resistance to anticancer immunity in cancer patients: potential strategies to reverse resistance.
B Bonavida, S Chouaib.
Ann Oncol, 2016 Nov 20; 28(3). PMID: 27864216    Free PMC article.
Unraveling the role of preexisting immunity in prostate cancer patients vaccinated with a HER-2/neu hybrid peptide.
Ioannis F Voutsas, Eleftheria A Anastasopoulou, +3 authors, Constantin N Baxevanis.
J Immunother Cancer, 2016 Nov 29; 4. PMID: 27891225    Free PMC article.
Immunotherapy of Malignant Tumors in the Brain: How Different from Other Sites?
Valérie Dutoit, Denis Migliorini, Pierre-Yves Dietrich, Paul R Walker.
Front Oncol, 2016 Dec 23; 6. PMID: 28003994    Free PMC article.
Predictive biomarkers for the efficacy of peptide vaccine treatment: based on the results of a phase II study on advanced pancreatic cancer.
Yoshitaro Shindo, Shoichi Hazama, +25 authors, Hiroaki Nagano.
J Exp Clin Cancer Res, 2017 Mar 01; 36(1). PMID: 28241889    Free PMC article.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.
Liliana E Lucca, David A Hafler.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258696    Free PMC article.
Cancer immunotherapy: how low-level ionizing radiation can play a key role.
Marek K Janiak, Marta Wincenciak, +2 authors, Edward J Calabrese.
Cancer Immunol Immunother, 2017 Apr 01; 66(7). PMID: 28361232    Free PMC article.
Epigenetic Strategies to Boost Cancer Immunotherapies.
Maria J Barrero.
Int J Mol Sci, 2017 May 27; 18(6). PMID: 28545238    Free PMC article.
Influence of opioids on immune function in patients with cancer pain: from bench to bedside.
Jason W Boland, A Graham Pockley.
Br J Pharmacol, 2017 Jun 09; 175(14). PMID: 28593737    Free PMC article.
Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy.
Hidemitsu Kitamura, Yosuke Ohno, +5 authors, Akinobu Taketomi.
Cancer Sci, 2017 Jul 28; 108(10). PMID: 28749573    Free PMC article.
A pilot study comparing T-regulatory cell function among healthy children in different areas of Gansu, China.
Panhong Gou, Xiaoru Chang, +5 authors, Sa Liu.
Environ Sci Pollut Res Int, 2017 Aug 16; 24(28). PMID: 28808862
Effects of preemptive analgesia with flurbiprofen ester on lymphocytes and natural killer cells in patients undergoing esophagectomy: A randomized controlled pilot study.
Yi Zhou, Jinxi Huang, +2 authors, Xihua Lu.
Thorac Cancer, 2017 Sep 12; 8(6). PMID: 28892265    Free PMC article.
The role and significance of VEGFR2+ regulatory T cells in tumor immunity.
Panrong Zhu, Chenxi Hu, Kaiyuan Hui, Xiaodong Jiang.
Onco Targets Ther, 2017 Sep 19; 10. PMID: 28919780    Free PMC article.
Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection.
Rocio Garcia-Carbonero, Ramon Salazar, +11 authors, Kerry Fisher.
J Immunother Cancer, 2017 Sep 20; 5(1). PMID: 28923104    Free PMC article.
Unconventional Pro-inflammatory CD4+ T Cell Response in B Cell-Deficient Mice Infected with Trypanosoma cruzi.
Melisa Gorosito Serrán, Jimena Tosello Boari, +8 authors, Adriana Gruppi.
Front Immunol, 2017 Dec 07; 8. PMID: 29209313    Free PMC article.
Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity.
Christophe Pedros, Ann J Canonigo-Balancio, Kok-Fai Kong, Amnon Altman.
JCI Insight, 2017 Dec 08; 2(23). PMID: 29212947    Free PMC article.
Immunotherapy and gene therapy as novel treatments for cancer.
Martha Montserrat Rangel-Sosa, Estuardo Aguilar-Córdova, Augusto Rojas-Martínez.
Colomb Med (Cali), 2017 Dec 08; 48(3). PMID: 29213157    Free PMC article.
Th17, synchronically increased with Tregs and Bregs , promoted by tumour cells via cell-contact in primary hepatic carcinoma.
W Wang, Z Wang, +8 authors, W Yu.
Clin Exp Immunol, 2017 Dec 23; 192(2). PMID: 29271479    Free PMC article.
The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion.
Marija Mojic, Kazuyoshi Takeda, Yoshihiro Hayakawa.
Int J Mol Sci, 2017 Dec 29; 19(1). PMID: 29283429    Free PMC article.
Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.
Vinit Shanbhag, Shrikesh Sachdev, +2 authors, Kamalendra Singh.
Biology (Basel), 2018 Jan 06; 7(1). PMID: 29301327    Free PMC article.
Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies.
Giovanni D'Arena, Candida Vitale, +9 authors, Daniela Fenoglio.
J Immunol Res, 2018 Feb 13; 2017. PMID: 29430466    Free PMC article.
Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC).
Young Kwang Chae, Sangmin Chang, +6 authors, Marcelo Cruz.
Sci Rep, 2018 Feb 15; 8(1). PMID: 29440769    Free PMC article.
Highly Cited.
Contribution of Regulatory T Cells in Nucleotide-Binding Oligomerization Domain 2 Response to Influenza Virus Infection.
Benoit Egarnes, Jean Gosselin.
Front Immunol, 2018 Feb 16; 9. PMID: 29445379    Free PMC article.
Regulatory T cells in retroviral infections.
Kim J Hasenkrug, Claire A Chougnet, Ulf Dittmer.
PLoS Pathog, 2018 Feb 16; 14(2). PMID: 29447279    Free PMC article.
Vitamin C Fosters the In Vivo Differentiation of Peripheral CD4+ Foxp3- T Cells into CD4+ Foxp3+ Regulatory T Cells but Impairs Their Ability to Prolong Skin Allograft Survival.
Karina Oyarce, Mauricio Campos-Mora, Tania Gajardo-Carrasco, Karina Pino-Lagos.
Front Immunol, 2018 Feb 27; 9. PMID: 29479348    Free PMC article.
FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity.
Theresa L Whiteside.
Expert Opin Ther Targets, 2018 Mar 14; 22(4). PMID: 29532697    Free PMC article.
Current Strategies to Enhance Anti-Tumour Immunity.
Katherine W Cook, Lindy G Durrant, Victoria A Brentville.
Biomedicines, 2018 Mar 24; 6(2). PMID: 29570634    Free PMC article.
Development of a vaccine based on bacteria-mimicking tumor cells coated with novel engineered toll-like receptor 2 ligands.
Takashi Akazawa, Toshimitsu Ohashi, +2 authors, Norimitsu Inoue.
Cancer Sci, 2018 Mar 27; 109(5). PMID: 29575556    Free PMC article.
FOXP3 expression is modulated by TGF‑β1/NOTCH1 pathway in human melanoma.
Eva Skarmoutsou, Valentina Bevelacqua, +5 authors, Claudio Guarneri.
Int J Mol Med, 2018 Apr 06; 42(1). PMID: 29620159    Free PMC article.
IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma.
S Mazher Hussain, Leighton F Reed, +10 authors, Evan S Glazer.
Sci Rep, 2018 Apr 13; 8(1). PMID: 29643359    Free PMC article.
TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.
Heng-Jia Liu, Patrick H Lizotte, +8 authors, Elizabeth P Henske.
JCI Insight, 2018 Apr 20; 3(8). PMID: 29669930    Free PMC article.
The Spleen as an Optimal Site for Islet Transplantation and a Source of Mesenchymal Stem Cells.
Naoaki Sakata, Gumpei Yoshimatsu, Shohta Kodama.
Int J Mol Sci, 2018 May 08; 19(5). PMID: 29735923    Free PMC article.
Norcantharidin enhances antitumor immunity of GM-CSF prostate cancer cells vaccine by inducing apoptosis of regulatory T cells.
Lijun Mo, Xinji Zhang, +6 authors, Zhiming Hu.
Cancer Sci, 2018 May 18; 109(7). PMID: 29770533    Free PMC article.
Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions.
Joanna Budna, Mariusz Kaczmarek, +6 authors, Jan Sikora.
J Immunol Res, 2018 May 23; 2018. PMID: 29785404    Free PMC article.
Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment.
Etienne D Foucher, Clément Ghigo, +3 authors, Daniel Olive.
Front Immunol, 2018 Jun 06; 9. PMID: 29868007    Free PMC article.
Downregulated Tim-3 expression is responsible for the incidence and development of colorectal cancer.
Ping Zhang, Yan Wang, +2 authors, Jian Yao.
Oncol Lett, 2018 Jul 03; 16(1). PMID: 29963183    Free PMC article.
MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers.
Yixin Yang, Christopher Alderman, +2 authors, Wei Wang.
Can J Gastroenterol Hepatol, 2018 Jul 27; 2018. PMID: 30046565    Free PMC article.
Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody.
Kyoko Yamaguchi, Koji Mishima, +12 authors, Eishi Baba.
Cancer Sci, 2018 Aug 02; 109(10). PMID: 30066977    Free PMC article.
Current landscape and future directions of biomarkers for predicting responses to immune checkpoint inhibitors.
Yingming Zhu, Fen Zhao, Zhenxiang Li, Jinming Yu.
Cancer Manag Res, 2018 Aug 21; 10. PMID: 30122997    Free PMC article.
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM.
Alice L Hung, Russell Maxwell, +20 authors, Michael Lim.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221069    Free PMC article.
Highly Cited.
Single-Cell Transcriptomics in Cancer Immunobiology: The Future of Precision Oncology.
Fatima Valdes-Mora, Kristina Handler, +4 authors, David Gallego-Ortega.
Front Immunol, 2018 Nov 30; 9. PMID: 30483257    Free PMC article.
Regulatory T cells: the ultimate HIV reservoir?
Joseph Rocco, John W Mellors, Bernard Jc Macatangay.
J Virus Erad, 2018 Dec 06; 4(4). PMID: 30515299    Free PMC article.
The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right.
Derek S Park, Mark Robertson-Tessi, +4 authors, Alexander R A Anderson.
Cancer Res, 2019 Aug 08; 79(20). PMID: 31387920    Free PMC article.
Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS.
Arjun Kalvala, Pierre Wallet, +15 authors, Ravi Salgia.
J Clin Med, 2019 Oct 23; 8(10). PMID: 31635338    Free PMC article.
The Role Of PD-1/PD-L1 Axis In Treg Development And Function: Implications For Cancer Immunotherapy.
Jiajing Cai, Dongsheng Wang, Guoyuan Zhang, Xiaolan Guo.
Onco Targets Ther, 2019 Nov 07; 12. PMID: 31686860    Free PMC article.
Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non-small-cell Lung Cancer.
Anders Tøndell, Sissel Gyrid Freim Wahl, +3 authors, Markus Haug.
Transl Oncol, 2019 Nov 17; 13(1). PMID: 31733591    Free PMC article.
The dynamics of the inflammatory response during BBN-induced bladder carcinogenesis in mice.
Marina Degoricija, Jelena Korac-Prlic, +6 authors, Janos Terzic.
J Transl Med, 2019 Nov 30; 17(1). PMID: 31779626    Free PMC article.
Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression.
Ju-Ha Kim, Jisung Hwang, +3 authors, Sung-Hoon Kim.
Mol Cancer, 2019 Dec 10; 18(1). PMID: 31815635    Free PMC article.
Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway.
Dianyun Ren, Jingyuan Zhao, +7 authors, Heshui Wu.
J Exp Clin Cancer Res, 2019 Dec 11; 38(1). PMID: 31818309    Free PMC article.
T follicular regulatory cells suppress Tfh-mediated B cell help and synergistically increase IL-10-producing B cells in breast carcinoma.
Hongsheng Song, Anzhou Liu, +2 authors, Zhitao Li.
Immunol Res, 2019 Aug 24; 67(4-5). PMID: 31440888
Risk of Cancers in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Results from the Korea National Health Insurance Claims Database 2010-2018.
Sung Soo Ahn, Minkyung Han, +5 authors, Sang-Won Lee.
J Clin Med, 2019 Nov 07; 8(11). PMID: 31694209    Free PMC article.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
Kazushige Yoshida, Masanori Okamoto, +13 authors, Naoto Saito.
BMC Cancer, 2020 Jan 10; 20(1). PMID: 31914969    Free PMC article.
T-Regulatory Cells In Tumor Progression And Therapy.
Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath.
Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383    Free PMC article.
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging.
Rachel Thomas, Weikan Wang, Dong-Ming Su.
Immun Ageing, 2020 Jan 29; 17. PMID: 31988649    Free PMC article.
Cancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells.
Xiaoxu Ge, Yamei Zhao, +2 authors, Lifeng Sun.
Onco Targets Ther, 2020 Jan 31; 12. PMID: 31997881    Free PMC article.
Molecular imaging biomarkers for immune checkpoint inhibitor therapy.
Pim P van de Donk, Laura Kist de Ruijter, +6 authors, Elisabeth Ge de Vries.
Theranostics, 2020 Feb 12; 10(4). PMID: 32042331    Free PMC article.
Bidirectional Crosstalk Between Cancer Stem Cells and Immune Cell Subsets.
Luise Müller, Antje Tunger, +6 authors, Marc Schmitz.
Front Immunol, 2020 Mar 03; 11. PMID: 32117287    Free PMC article.
Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus.
Anniek Zaalberg, Sara Moradi Tuchayi, +9 authors, Shadmehr Demehri.
J Invest Dermatol, 2018 Jul 22; 139(1). PMID: 30030152    Free PMC article.
Cancer Stem Cells and Immunosuppressive Microenvironment in Glioma.
Qianquan Ma, Wenyong Long, +5 authors, Rong-Fu Wang.
Front Immunol, 2019 Jan 09; 9. PMID: 30619286    Free PMC article.
The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis.
Paul Laissue.
Mol Cancer, 2019 Jan 10; 18(1). PMID: 30621735    Free PMC article.
Highly Cited. Review.
Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis.
Avijit Ray, Mohamed I Khalil, +6 authors, Bonnie N Dittel.
Nat Commun, 2019 Jan 16; 10(1). PMID: 30643147    Free PMC article.
Accumulation of exhausted CD8+ T cells in extramammary Paget's disease.
Natsuko Iga, Atsushi Otsuka, +16 authors, Kenji Kabashima.
PLoS One, 2019 Jan 27; 14(1). PMID: 30682105    Free PMC article.
Microenvironment tailors nTreg structure and function.
Valérie Schiavon, Sophie Duchez, +19 authors, Hélène Le Buanec.
Proc Natl Acad Sci U S A, 2019 Mar 09; 116(13). PMID: 30846549    Free PMC article.
Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy.
Quoc-Viet Le, Juhan Suh, Yu-Kyoung Oh.
AAPS J, 2019 May 19; 21(4). PMID: 31102154
Role of tumor-associated immune cells in prostate cancer: angel or devil?
Shui-Qing Wu, Hao Su, Yin-Huai Wang, Xiao-Kun Zhao.
Asian J Androl, 2019 May 29; 21(5). PMID: 31134920    Free PMC article.
Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy.
Jung-Ho Kim, Beom Seok Kim, Sang-Kyou Lee.
Immune Netw, 2020 Mar 12; 20(1). PMID: 32158592    Free PMC article.
Prognostic value of the expression of chemokines and their receptors in regional lymph nodes of melanoma patients.
Ting-Feng Xiong, Fu-Qiang Pan, +4 authors, Xiang Zhou.
J Cell Mol Med, 2020 Jan 27; 24(6). PMID: 31983065    Free PMC article.
Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer.
Andrew M K Law, Fatima Valdes-Mora, David Gallego-Ortega.
Cells, 2020 Mar 04; 9(3). PMID: 32121014    Free PMC article.
The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review.
Qiancheng Deng, Yangyang Luo, +3 authors, Rong Xiao.
Front Immunol, 2019 May 07; 10. PMID: 31057561    Free PMC article.
Systematic Review.
Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series.
Terufumi Kubo, Giichiro Tsurita, +17 authors, Toshihiko Torigoe.
Cancer Sci, 2019 Jun 18; 110(8). PMID: 31206934    Free PMC article.
Dawn of Monitoring Regulatory T Cells in (Pre-)clinical Studies: Their Relevance Is Slowly Recognised.
A Charlotte M T de Wolf, Carla A Herberts, Marcel H N Hoefnagel.
Front Med (Lausanne), 2020 Apr 18; 7. PMID: 32300597    Free PMC article.
Systematic Review.
High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity.
Ralf Willebrand, Ibrahim Hamad, +13 authors, Markus Kleinewietfeld.
Front Immunol, 2019 Jun 20; 10. PMID: 31214164    Free PMC article.
Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity - A Mini-Review.
Weikan Wang, Rachel Thomas, Olga Sizova, Dong-Ming Su.
Front Immunol, 2020 May 20; 11. PMID: 32425946    Free PMC article.
The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies.
Florent Petitprez, Maxime Meylan, +2 authors, Wolf H Fridman.
Front Immunol, 2020 May 28; 11. PMID: 32457745    Free PMC article.
Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia.
Yuling Wan, Congxiao Zhang, +8 authors, Jianxiang Wang.
BMC Cancer, 2020 May 28; 20(1). PMID: 32456622    Free PMC article.
Treg regulation of the epithelial stem cell lineage.
Inchul Cho, Prudence Pokwai Lui, Niwa Ali.
J Immunol Regen Med, 2020 Jun 05; 8. PMID: 32494759    Free PMC article.
Guillain-Barre syndrome induced by pembrolizumab and sunitinib: A case report.
Chen Han, Jin-An Ma, +3 authors, Yuanqiang Wu.
Mol Clin Oncol, 2020 Jun 06; 13(1). PMID: 32499912    Free PMC article.
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies.
Rodolfo Daniel Cervantes-Villagrana, Damaris Albores-García, Alberto Rafael Cervantes-Villagrana, Sara Judit García-Acevez.
Signal Transduct Target Ther, 2020 Jun 20; 5(1). PMID: 32555170    Free PMC article.
Prostaglandin E2 Reverses the Effects of DNA Methyltransferase Inhibitor and TGFB1 on the Conversion of Naive T Cells to iTregs.
Mehmet Sahin, Emel Sahin.
Transfus Med Hemother, 2020 Jul 01; 47(3). PMID: 32595429    Free PMC article.
The Effect of Antibody Fragments on CD25 Targeted Regulatory T Cell Near-Infrared Photoimmunotherapy.
Ryuhei Okada, Yasuhiro Maruoka, +5 authors, Hisataka Kobayashi.
Bioconjug Chem, 2019 Sep 10; 30(10). PMID: 31498995    Free PMC article.
Increase in CD4+FOXP3+ regulatory T cell number and upregulation of the HGF/c-Met signaling pathway during the liver metastasis of colorectal cancer.
Xiaoming Huang, Zexian Chen, +6 authors, Yunle Wan.
Oncol Lett, 2020 Aug 13; 20(3). PMID: 32782528    Free PMC article.
Novel combination immunotherapy for pancreatic cancer: potent anti-tumor effects with CD40 agonist and interleukin-15 treatment.
Jonas Rm Van Audenaerde, Elly Marcq, +13 authors, Evelien Ljm Smits.
Clin Transl Immunology, 2020 Aug 22; 9(8). PMID: 32821382    Free PMC article.
Immuno-Surgical Management of Pancreatic Cancer with Analysis of Cancer Exosomes.
Yu Takeda, Shogo Kobayashi, +14 authors, Hideshi Ishii.
Cells, 2020 Jul 15; 9(7). PMID: 32659892    Free PMC article.
Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity.
Sandra Grund-Gröschke, Daniela Ortner, +11 authors, Fritz Aberger.
Mol Oncol, 2020 Jul 03; 14(9). PMID: 32615027    Free PMC article.
Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation.
Robert L Ferris, Heinz-Josef Lenz, +5 authors, Gerard Milano.
Cancer Treat Rev, 2017 Dec 11; 63. PMID: 29223828    Free PMC article.
Oxymatrine and Cisplatin Synergistically Enhance Anti-tumor Immunity of CD8+ T Cells in Non-small Cell Lung Cancer.
Jin Ye, Man-Man Zou, +10 authors, Hui Liu.
Front Oncol, 2019 Jan 09; 8. PMID: 30619765    Free PMC article.
The Therapeutic Strategies of Regulatory T Cells in Malignancies and Stem Cell Transplantations.
Rana G Zaini, Amani A Al-Rehaili.
J Oncol, 2019 Jan 30; 2019. PMID: 30693029    Free PMC article.
Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma.
Karishma R Rajani, Lucas P Carlstrom, +3 authors, Terry C Burns.
Front Oncol, 2019 Mar 12; 8. PMID: 30854331    Free PMC article.
Hydroxyl safflower yellow A regulates the tumor immune microenvironment to produce an anticancer effect in a mouse model of hepatocellular carcinoma.
Yicong Ma, Cuiling Feng, +10 authors, Xu-Hui Li.
Oncol Lett, 2019 Mar 15; 17(3). PMID: 30867790    Free PMC article.
Consequences of EMT-Driven Changes in the Immune Microenvironment of Breast Cancer and Therapeutic Response of Cancer Cells.
Snahlata Singh, Rumela Chakrabarti.
J Clin Med, 2019 May 12; 8(5). PMID: 31075939    Free PMC article.
T lymphocytes against solid malignancies: winning ways to defeat tumours.
Ignazio Caruana, Luca Simula, Franco Locatelli, Silvia Campello.
Cell Stress, 2019 Jun 22; 2(8). PMID: 31225487    Free PMC article.
Tumor Infiltrating Regulatory T Cells in Sporadic and Colitis-Associated Colorectal Cancer: The Red Little Riding Hood and the Wolf.
Massimo Claudio Fantini, Agnese Favale, Sara Onali, Federica Facciotti.
Int J Mol Sci, 2020 Sep 18; 21(18). PMID: 32937953    Free PMC article.
In-depth characterization of the biomarkers based on tumor-infiltrated immune cells reveals implications for diagnosis and prognosis in hepatocellular carcinoma.
Wenbiao Chen, Kefan Bi, +2 authors, Hongyan Diao.
J Transl Autoimmun, 2020 Oct 20; 3. PMID: 33073226    Free PMC article.
Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3.
Sarah Nicol Lauder, Kathryn Smart, +15 authors, Awen Gallimore.
J Immunother Cancer, 2020 Oct 24; 8(2). PMID: 33093155    Free PMC article.
Role of Nurr1 in Carcinogenesis and Tumor Immunology: A State of the Art Review.
Peter Kok-Ting Wan, Michelle Kwan-Yee Siu, +3 authors, Hextan Yuen-Sheung Ngan.
Cancers (Basel), 2020 Oct 23; 12(10). PMID: 33086676    Free PMC article.
Future of immune checkpoint inhibitors: focus on tumor immune microenvironment.
Yunlong Jia, Lihua Liu, Baoen Shan.
Ann Transl Med, 2020 Nov 05; 8(17). PMID: 33145314    Free PMC article.
Study and analysis of antitumor resistance mechanism of PD1/PD-L1 immune checkpoint blocker.
Zhengyi Wang, Xiaoying Wu.
Cancer Med, 2020 Sep 03; 9(21). PMID: 32875727    Free PMC article.
Regulatory T Cells in Angiogenesis.
Zala Lužnik, Sonia Anchouche, Reza Dana, Jia Yin.
J Immunol, 2020 Nov 11; 205(10). PMID: 33168598    Free PMC article.
Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome.
Dustin L Norton, Agathe Ceppe, +9 authors, Jason R Mock.
J Transl Med, 2020 Nov 13; 18(1). PMID: 33176790    Free PMC article.
Comprehensive flow cytometric reference intervals of leukocyte subsets from six study centers across Europe.
A Oras, B Quirant-Sanchez, +9 authors, T Giese.
Clin Exp Immunol, 2020 Jul 13; 202(3). PMID: 32654132    Free PMC article.
Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.
Stephen P Hack, Andrew X Zhu, Yulei Wang.
Front Immunol, 2020 Dec 01; 11. PMID: 33250900    Free PMC article.
Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study).
Satoshi Nishiwaki, Isamu Sugiura, +16 authors, Hitoshi Kiyoi.
Medicine (Baltimore), 2018 Feb 01; 96(52). PMID: 29384978    Free PMC article.
Recent Advances in the Clinical Development of Immune Checkpoint Blockade Therapy for Mismatch Repair Proficient (pMMR)/non-MSI-H Metastatic Colorectal Cancer.
James J Lee, Edward Chu.
Clin Colorectal Cancer, 2018 Aug 04; 17(4). PMID: 30072278    Free PMC article.
Overexpression of Regulatory T Cell-Related Markers (FOXP3, CTLA-4 and GITR) by Peripheral Blood Mononuclear Cells from Patients with Breast Cancer
Esmat Khalife, Ali Khodadadi, +3 authors, Abdollah Jafarzadeh.
Asian Pac J Cancer Prev, 2018 Nov 30; 19(11). PMID: 30484986    Free PMC article.
TGF-β Inhibitors in Metastatic Pancreatic Ductal Adenocarcinoma.
Marcus A Alvarez, Júlia Pedó Freitas, S Mazher Hussain, Evan S Glazer.
J Gastrointest Cancer, 2019 Mar 21; 50(2). PMID: 30891677
Umbilical cord blood‑derived Helios‑positive regulatory T cells promote angiogenesis in acute lymphoblastic leukemia in mice via CCL22 and the VEGFA‑VEGFR2 pathway.
Xue Li, Dong Li, +2 authors, Xiuli Ju.
Mol Med Rep, 2019 Mar 22; 19(5). PMID: 30896872    Free PMC article.
CD4+CD25highCD127low/-FoxP3 + Regulatory T-Cell Population in Acute Leukemias: A Review of the Literature.
M Niedźwiecki, O Budziło, +5 authors, P Trzonkowski.
J Immunol Res, 2019 Apr 05; 2019. PMID: 30944830    Free PMC article.
<Editors' Choice> Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity.
Vitaly Kochin, Hiroyoshi Nishikawa.
Nagoya J Med Sci, 2019 Apr 10; 81(1). PMID: 30962651    Free PMC article.
Multifaceted Role of the Placental Growth Factor (PlGF) in the Antitumor Immune Response and Cancer Progression.
Loredana Albonici, Maria Gabriella Giganti, +2 authors, Roberto Bei.
Int J Mol Sci, 2019 Jun 21; 20(12). PMID: 31216652    Free PMC article.
T Regulatory CD4+CD25+FoxP3+ Lymphocytes in the Peripheral Blood of Left-Sided Colorectal Cancer Patients.
Katarzyna Dylag-Trojanowska, Joanna Rogala, +7 authors, Antoni M Szczepanik.
Medicina (Kaunas), 2019 Jun 28; 55(6). PMID: 31242584    Free PMC article.
What could microRNA expression tell us more about colorectal serrated pathway carcinogenesis?
Milena Peruhova, Monika Peshevska-Sekulovska, +5 authors, Tsvetelina Veselinova Velikova.
World J Gastroenterol, 2020 Dec 04; 26(42). PMID: 33268946    Free PMC article.
Prognostic significance of CD4-positive regulatory T cells in tumor draining lymph nodes from patients with bladder cancer.
Ali Ariafar, Yasmin Vahidi, +3 authors, Zahra Faghih.
Heliyon, 2020 Dec 12; 6(12). PMID: 33305045    Free PMC article.
Competitive glucose metabolism as a target to boost bladder cancer immunotherapy.
Julieta Afonso, Lúcio L Santos, Adhemar Longatto-Filho, Fátima Baltazar.
Nat Rev Urol, 2020 Jan 19; 17(2). PMID: 31953517
The role of the programmed cell death protein-1/programmed death-ligand 1 pathway, regulatory T cells and T helper 17 cells in tumor immunity: a narrative review.
Lanfang Zhang, Mingjuan Zhang, +6 authors, Meiling Gu.
Ann Transl Med, 2020 Dec 15; 8(22). PMID: 33313271    Free PMC article.
Epigenetic modulation of immunotherapy and implications in head and neck cancer.
Liye Zhou, Na Xu, +2 authors, Ravindra Uppaluri.
Cancer Metastasis Rev, 2021 Jan 07; 40(1). PMID: 33403469    Free PMC article.
The Multiple Potential Biomarkers for Predicting Immunotherapy Response-Finding the Needle in the Haystack.
Tamiem Adam, Therese M Becker, +2 authors, Tara L Roberts.
Cancers (Basel), 2021 Jan 17; 13(2). PMID: 33451015    Free PMC article.
Differential immune microenvironmental features of microsatellite-unstable colorectal cancers according to Fusobacterium nucleatum status.
Ji Ae Lee, Seung-Yeon Yoo, +4 authors, Jung Ho Kim.
Cancer Immunol Immunother, 2020 Jul 06; 70(1). PMID: 32623478
The Dark Side of the Force: When the Immune System Is the Fuel of Tumor Onset.
Elisabeth Digifico, Silvia Balinzo, Cristina Belgiovine.
Int J Mol Sci, 2021 Jan 31; 22(3). PMID: 33513730    Free PMC article.
T Cells in Chronic Lymphocytic Leukemia: A Two-Edged Sword.
Elisavet Vlachonikola, Kostas Stamatopoulos, Anastasia Chatzidimitriou.
Front Immunol, 2021 Feb 09; 11. PMID: 33552073    Free PMC article.
Oncolytic virotherapy: new weapon for breast cancer treatment.
Veronica Martini, Francesca D'Avanzo, +3 authors, Alessandra Gennari.
Ecancermedicalscience, 2021 Feb 13; 14. PMID: 33574894    Free PMC article.
Immune Cluster and PPI Network Analyses Identified CXCR3 as a Key Node of Immunoregulation in Head and Neck Cancer.
Ping Wang, Yanli Wang, +3 authors, Qiao Qiao.
Front Oncol, 2021 Feb 16; 10. PMID: 33585188    Free PMC article.
Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function.
Yogesh Singh, Madhuri S Salker, Florian Lang.
Front Nutr, 2021 Feb 16; 7. PMID: 33585537    Free PMC article.
Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology.
Livia Odagiu, Julia May, +2 authors, Nathalie Labrecque.
Front Endocrinol (Lausanne), 2021 Feb 19; 11. PMID: 33597928    Free PMC article.
Systems biology analysis identifies TNFRSF9 as a functional marker of tumor-infiltrating regulatory T-cell enabling clinical outcome prediction in lung cancer.
Jae-Won Cho, Jimin Son, Sang-Jun Ha, Insuk Lee.
Comput Struct Biotechnol J, 2021 Feb 19; 19. PMID: 33598101    Free PMC article.
Progress and Clinical Application of Single-Cell Transcriptional Sequencing Technology in Cancer Research.
Jian Liu, Tianmin Xu, +2 authors, Yan Zhang.
Front Oncol, 2021 Feb 23; 10. PMID: 33614479    Free PMC article.
Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling.
Snahlata Singh, Sushil Kumar, +13 authors, Rumela Chakrabarti.
Nat Cell Biol, 2020 Apr 15; 22(5). PMID: 32284542    Free PMC article.
Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis.
Maryam Aftabizadeh, Yi-Jia Li, +9 authors, Andreas Herrmann.
JCI Insight, 2021 Jan 26; 6(2). PMID: 33491667    Free PMC article.
Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review).
Junmin Wang, Hongjiao Xiang, Yifei Lu, Tao Wu.
Int J Mol Med, 2021 Feb 20; 47(4). PMID: 33604683    Free PMC article.
Retinoblastoma cell-derived Twist protein promotes regulatory T cell development.
Ruishi Zhang, Yan-Nan Song, +7 authors, Guohui Nie.
Cancer Immunol Immunother, 2020 Oct 28; 70(4). PMID: 33108472
Identification of prognostic immune-related genes in rhabdoid tumor of kidney based on TARGET database analysis.
Huimou Chen, Suying Lu, +9 authors, Yizhuo Zhang.
Aging (Albany NY), 2021 Feb 16; 13(4). PMID: 33588380    Free PMC article.
Low expression of BTN3A3 indicates poor prognosis and promotes cell proliferation, migration and invasion in non-small cell lung cancer.
Xu Cheng, Tianyu Ma, +7 authors, Zhidong Liu.
Ann Transl Med, 2021 Apr 15; 9(6). PMID: 33850875    Free PMC article.
Mucin 4 mutation is associated with tumor mutation burden and promotes antitumor immunity in colon cancer patients.
Linglong Peng, Yang Li, +5 authors, Jijian Wang.
Aging (Albany NY), 2021 Mar 15; 13(6). PMID: 33714943    Free PMC article.
Exercise-Induced Changes in Tumor Growth via Tumor Immunity.
Polyxeni Spiliopoulou, Maria Gavriatopoulou, +2 authors, Gerasimos Terzis.
Sports (Basel), 2021 Apr 04; 9(4). PMID: 33808154    Free PMC article.
Targeting regulatory T cells for improving cancer therapy: Challenges and prospects.
Bilikere S Dwarakanath, Abdullah Farooque, Seema Gupta.
Cancer Rep (Hoboken), 2018 Jun 01; 1(1). PMID: 32729245    Free PMC article.
The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging.
Natarajan Bhaskaran, Sangeetha Jayaraman, +6 authors, Pushpa Pandiyan.
Front Oncol, 2021 May 11; 11. PMID: 33968777    Free PMC article.
KIF11 Serves as an Independent Prognostic Factor and Therapeutic Target for Patients With Lung Adenocarcinoma.
Zhaodong Li, Bingxin Yu, Fangyuan Qi, Fan Li.
Front Oncol, 2021 May 11; 11. PMID: 33968780    Free PMC article.
Comprehensive analysis of competitive endogenous RNA associated with immune infiltration in lung adenocarcinoma.
Wenjie Chen, Wen Li, +5 authors, Qinghua Zhou.
Sci Rep, 2021 May 28; 11(1). PMID: 34040139    Free PMC article.
The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study.
Satu Salmi, Anton Lin, +5 authors, Sanna Pasonen-Seppänen.
BMC Cancer, 2021 May 31; 21(1). PMID: 34051744    Free PMC article.
FOXP3-based immune risk model for recurrence prediction in small-cell lung cancer at stages I-III.
Minlin Jiang, Chunyan Wu, +13 authors, Caicun Zhou.
J Immunother Cancer, 2021 May 20; 9(5). PMID: 34006632    Free PMC article.
Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy.
Takuya Kato, Hiroaki Wakiyama, +2 authors, Hisataka Kobayashi.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34064074    Free PMC article.
Analyzing and Validating the Prognostic Value of a TNF-Related Signature in Kidney Renal Clear Cell Carcinoma.
Wenhao Zhang, Changjiu Li, +6 authors, Huadong He.
Front Mol Biosci, 2021 Jun 15; 8. PMID: 34124165    Free PMC article.
Novel Prognostic Biomarkers in Gastric Cancer: CGB5, MKNK2, and PAPPA2.
Min Qin, Zhihai Liang, +4 authors, Guodu Tang.
Front Oncol, 2021 Jul 06; 11. PMID: 34222004    Free PMC article.
Combination immunotherapy with two attenuated Listeria strains carrying shuffled HPV-16 E6E7 protein causes tumor regression in a mouse tumor model.
Lin Su, Yunwen Zhang, +7 authors, Chuan Wang.
Sci Rep, 2021 Jun 30; 11(1). PMID: 34183739    Free PMC article.
TGF-β Alters the Proportion of Infiltrating Immune Cells in a Pancreatic Ductal Adenocarcinoma.
Kasia Trebska-McGowan, Mehdi Chaib, +5 authors, Evan S Glazer.
J Gastrointest Surg, 2021 Jul 15; 26(1). PMID: 34260016
IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma.
Quan Meng, Can-Xuan Li, Dan Long, Xiaobin Lin.
Int J Gen Med, 2021 Jul 22; 14. PMID: 34285569    Free PMC article.
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.
Eros Di Giorgio, Liqing Wang, +8 authors, Wayne W Hancock.
Front Immunol, 2021 Jul 23; 12. PMID: 34290714    Free PMC article.
Fundamental and Essential Knowledge for Pathologists Engaged in the Research and Practice of Immune Checkpoint Inhibitor-Based Cancer Immunotherapy.
Terufumi Kubo, Tomoyo Shinkawa, +5 authors, Toshihiko Torigoe.
Front Oncol, 2021 Jul 23; 11. PMID: 34290982    Free PMC article.
Alternol triggers immunogenic cell death via reactive oxygen species generation.
Changlin Li, Ying Zhang, +4 authors, Benyi Li.
Oncoimmunology, 2021 Aug 06; 10(1). PMID: 34350063    Free PMC article.
Prognostic Value of Tumor Infiltrating Lymphocytes in Nasopharyngeal Carcinoma Patients: Meta-Analysis.
Birhanu Aberha Berele, Yuxiang Cai, Guifang Yang.
Technol Cancer Res Treat, 2021 Jul 30; 20. PMID: 34323154    Free PMC article.
FOXP3 and CTLA-4 genetic variants' influence on the susceptibility and clinical course of basal cell carcinoma.
Martyna Sławińska, Monika Zabłotna, Roman J Nowicki, Michał Sobjanek.
Postepy Dermatol Alergol, 2021 Aug 12; 38(3). PMID: 34377128    Free PMC article.
Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study.
Dmitriy Zamarin, Omid Hamid, +6 authors, David S Hong.
Clin Cancer Res, 2020 Jun 27; 26(17). PMID: 32586937    Free PMC article.
Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications.
Andrea Comba, Syed M Faisal, +7 authors, Pedro R Lowenstein.
Front Oncol, 2021 Aug 24; 11. PMID: 34422657    Free PMC article.
CCL5/CCR5 axis in human diseases and related treatments.
Zhen Zeng, Tianxia Lan, Yuquan Wei, Xiawei Wei.
Genes Dis, 2021 Sep 14; 9(1). PMID: 34514075    Free PMC article.
Clinical and immunological allergy assessment in cancer patients.
Bruno Gustavo Muzzi Carvalho Carneiro, Andy Petroianu, +5 authors, Sofia Candia Barrientos.
Sci Rep, 2021 Sep 15; 11(1). PMID: 34518597    Free PMC article.
Upregulation of Cytotoxic T-Lymphocyte-Associated Protein 4 and Forkhead Box P3 Transcripts in Peripheral Blood of Patients with Bladder Cancer.
Ali Ariafar, Mojtaba Habibagahi, +5 authors, Mahboobeh Razmkhah.
Iran J Med Sci, 2021 Sep 21; 46(5). PMID: 34539008    Free PMC article.
Comparison of Tumor Microenvironments Between Primary Tumors and Brain Metastases in Patients With NSCLC.
Daiki Ikarashi, Tamio Okimoto, +7 authors, David P Carbone.
JTO Clin Res Rep, 2021 Oct 15; 2(10). PMID: 34647108    Free PMC article.
Regulatory T-Cells and Multiple Myeloma: Implications in Tumor Immune Biology and Treatment.
Christina Hadjiaggelidou, Eirini Katodritou.
J Clin Med, 2021 Oct 14; 10(19). PMID: 34640606    Free PMC article.
Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: a randomized controlled trial.
Ai Yamaguchi, Izumi Kawagoe, +4 authors, Masakazu Hayashida.
J Thorac Dis, 2021 Oct 19; 13(9). PMID: 34659809    Free PMC article.
[Effects of neoadjuvant chemoradiotherapy on infiltrating immune cells in the tumor microenvironment of rectal cancer].
Q Yang, C Zhou, +4 authors, J Ma.
Nan Fang Yi Ke Da Xue Xue Bao, 2021 Sep 23; 41(8). PMID: 34549721    Free PMC article.
Regulatory T Cells: Regulation of Identity and Function.
Payal Grover, Peeyush N Goel, Mark I Greene.
Front Immunol, 2021 Oct 23; 12. PMID: 34675933    Free PMC article.
Helicobacter pylori in gastric cancer: Features of infection and their correlations with long-term results of treatment.
Marina A Senchukova, Olesya Tomchuk, Elena I Shurygina.
World J Gastroenterol, 2021 Oct 30; 27(37). PMID: 34712033    Free PMC article.
Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer.
Wenqing Tang, Fangshi Xu, Meng Zhao, Shuqun Zhang.
BMC Cancer, 2021 Oct 31; 21(1). PMID: 34715817    Free PMC article.
Anti-Tumor Effects of Chinese Medicine Compounds by Regulating Immune Cells in Microenvironment.
Fengqian Chen, Jingquan Li, Hui Wang, Qian Ba.
Front Oncol, 2021 Nov 02; 11. PMID: 34722304    Free PMC article.
Modulation of T-cell Regulators Associated with Advanced Stage of Prostate Cancer.
Kurnia Penta Seputra, Handono Kalim, +3 authors, Athaya Febriantyo Purnomo.
Acta Inform Med, 2021 Nov 12; 29(3). PMID: 34759457    Free PMC article.
Pretreatment tumour immune microenvironment predicts clinical response and prognosis of muscle-invasive bladder cancer in the neoadjuvant chemotherapy setting.
Daiki Ikarashi, Shigehisa Kitano, +12 authors, Wataru Obara.
Br J Cancer, 2021 Nov 17; 126(4). PMID: 34782748    Free PMC article.
Immune checkpoint inhibition for pancreatic ductal adenocarcinoma: limitations and prospects: a systematic review.
Hong-Bo Li, Zi-Han Yang, Qing-Qu Guo.
Cell Commun Signal, 2021 Nov 26; 19(1). PMID: 34819086    Free PMC article.
Targeting myeloid-derived suppressor cells for cancer therapy.
Hongchao Tang, Hao Li, Zhijun Sun.
Cancer Biol Med, 2021 Aug 18;. PMID: 34403220    Free PMC article.
Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia.
Yuki Fujioka, Daisuke Sugiyama, +8 authors, Naoto Takahashi.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885012    Free PMC article.
The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer.
Yaping Chen, Xiao Zheng, Changping Wu.
Front Immunol, 2021 Dec 21; 12. PMID: 34925375    Free PMC article.
The Effects of Differentially-Expressed Homeobox Family Genes on the Prognosis and HOXC6 on Immune Microenvironment Orchestration in Colorectal Cancer.
Lina Qi, Chenyang Ye, +4 authors, Ying Yuan.
Front Immunol, 2021 Dec 25; 12. PMID: 34950145    Free PMC article.
Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance?
Sultana Mehbuba Hossain, Chiemi F Lynch-Sutherland, +2 authors, Michael R Eccles.
Epigenomes, 2021 Dec 31; 5(3). PMID: 34968365    Free PMC article.
Breast Cancer Tumor Microenvironment and Molecular Aberrations Hijack Tumoricidal Immunity.
Huey-Jen Lin, Yingguang Liu, Denene Lofland, Jiayuh Lin.
Cancers (Basel), 2022 Jan 22; 14(2). PMID: 35053449    Free PMC article.
Metabolic Understanding of the Genetic Dysregulation in the Tumor Microenvironment of Kidney Renal Clear Cell Carcinoma.
Junwei Xie, Lingang Cui, +3 authors, Zhangsuo Liu.
Dis Markers, 2022 Feb 01; 2022. PMID: 35096203    Free PMC article.
Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders.
Liye Zhou, Zexian Zeng, +21 authors, Ravindra Uppaluri.
J Immunother Cancer, 2022 Jan 22; 10(1). PMID: 35058328    Free PMC article.
Inflammation-Related Gene Signature: An Individualized Risk Prediction Model for Kidney Renal Clear Cell Carcinoma.
Ze Zhang, Yan-Yan Wei, +6 authors, Hui-Li Li.
J Oncol, 2022 Feb 11; 2022. PMID: 35140786    Free PMC article.
Circulating regulatory T cells predict efficacy and atypical responses in lung cancer patients treated with PD-1/PD-L1 inhibitors.
Da Hyun Kang, Chaeuk Chung, +7 authors, Jeong Eun Lee.
Cancer Immunol Immunother, 2021 Jul 20; 71(3). PMID: 34278517    Free PMC article.
Liver Tropism in Cancer: The Hepatic Metastatic Niche.
Ainhoa Mielgo, Michael C Schmid.
Cold Spring Harb Perspect Med, 2019 Sep 25; 10(3). PMID: 31548227    Free PMC article.
A pan-cancer analysis on the carcinogenic effect of human adenomatous polyposis coli.
Yinci Zhang, Xinkuang Liu, Amin Li, Xiaolong Tang.
PLoS One, 2022 Mar 19; 17(3). PMID: 35303016    Free PMC article.
A Novel Pyroptosis-Related Prognostic Signature for Risk Stratification and Clinical Prognosis in Clear Cell Renal Cell Carcinoma.
Xiao-Qiong Pan, Wen Huang, +2 authors, Xiao-Yan Xu.
Dis Markers, 2022 Mar 22; 2022. PMID: 35308143    Free PMC article.
Analysis of Ferroptosis-Related LncRNAs Signatures Associated with Tumor Immune Infiltration and Experimental Validation in Clear Cell Renal Cell Carcinoma.
Xinyi Chen, Jingyao Tu, +3 authors, Xianglin Yuan.
Int J Gen Med, 2022 Mar 29; 15. PMID: 35342303    Free PMC article.
The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer.
Miya Haruna, Azumi Ueyama, +13 authors, Hisashi Wada.
Sci Rep, 2022 Apr 01; 12(1). PMID: 35354899    Free PMC article.
Immune Landscape in PTEN-Related Glioma Microenvironment: A Bioinformatic Analysis.
Alice Giotta Lucifero, Sabino Luzzi.
Brain Sci, 2022 Apr 22; 12(4). PMID: 35448032    Free PMC article.
Prognostic biomarkers related to tumoral microenvironment in pancreatic ductal adenocarcinoma: a systematic review.
Alina Liliana Constantin, Irina Mihaela Cazacu, +2 authors, Adrian Săftoiu.
Rom J Morphol Embryol, 2022 Mar 10; 62(3). PMID: 35263394    Free PMC article.
Systematic Review.
Identification of autophagy-related biomarker and analysis of immune infiltrates in oral carcinoma.
Honghai Fu, Dianguo Zhao, +2 authors, Xiangrui Ma.
J Clin Lab Anal, 2022 Apr 15; 36(5). PMID: 35421271    Free PMC article.
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape.
Qinghua Wu, Li You, +4 authors, Vojtech Adam.
J Hematol Oncol, 2022 Jun 07; 15(1). PMID: 35659268