. 2016 Oct;13(11).
doi: 10.1038/nrclinonc.2016.66.

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

Giampaolo Bianchini 1 Justin M Balko 2 Ingrid A Mayer 2 Melinda E Sanders 3 Luca Gianni 1 
  • PMID: 27184417
  •     178 References
  •     425 citations


Chemotherapy is the primary established systemic treatment for patients with triple-negative breast cancer (TNBC) in both the early and advanced-stages of the disease. The lack of targeted therapies and the poor prognosis of patients with TNBC have fostered a major effort to discover actionable molecular targets to treat patients with these tumours. Massively parallel sequencing and other 'omics' technologies have revealed an unexpected level of heterogeneity of TNBCs and have led to the identification of potentially actionable molecular features in some TNBCs, such as germline BRCA1/2 mutations or 'BRCAness', the presence of the androgen receptor, and several rare genomic alterations. Whether these alterations are molecular 'drivers', however, has not been clearly established. A subgroup of TNBCs shows a high degree of tumour-infiltrating lymphocytes that also correlates with a lower risk of disease relapse and a higher likelihood of benefit from chemotherapy. Proof-of-principle studies with immune-checkpoint inhibitors in advanced-stage TNBC have yielded promising results, indicating the potential benefit of immunotherapy for patients with TNBC. In this Review, we discuss the most relevant molecular findings in TNBC from the past decade and the most promising therapeutic opportunities derived from these data.

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Highly Cited. Review.
TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer.
Lisa A Carey, Hope S Rugo, +17 authors, Eric P Winer.
J Clin Oncol, 2012 Jun 06; 30(21). PMID: 22665533    Free PMC article.
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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Richard M Neve, Koei Chin, +24 authors, Joe W Gray.
Cancer Cell, 2006 Dec 13; 10(6). PMID: 17157791    Free PMC article.
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Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade.
S L Ding, L F Sheu, +4 authors, C Y Shen.
Br J Cancer, 2004 May 13; 90(10). PMID: 15138484    Free PMC article.
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
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Annu Rev Pathol, 2008 Oct 29; 4. PMID: 18954285
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
Nicholas C Turner, Christopher J Lord, +6 authors, Alan Ashworth.
EMBO J, 2008 Apr 05; 27(9). PMID: 18388863    Free PMC article.
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Structural representations of tumor-host relationships in mammary carcinoma; biologic and prognostic significance.
Am J Clin Pathol, 1956 Mar 01; 26(3). PMID: 13302171
T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers.
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Breast Cancer Res, 2009 Mar 11; 11(2). PMID: 19272155    Free PMC article.
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New Strategies in Breast Cancer: Immunotherapy.
Lajos Pusztai, Thomas Karn, +2 authors, Giampaolo Bianchini.
Clin Cancer Res, 2016 Feb 13; 22(9). PMID: 26867935
Taxanes in breast cancer: an update.
Alison K Conlin, Andrew D Seidman.
Curr Oncol Rep, 2006 Dec 14; 9(1). PMID: 17164044
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study.
Karen A Gelmon, Marc Tischkowitz, +11 authors, Amit Oza.
Lancet Oncol, 2011 Aug 25; 12(9). PMID: 21862407
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BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles.
Evan Matros, Zhigang C Wang, +3 authors, Andrea L Richardson.
Breast Cancer Res Treat, 2005 May 04; 91(2). PMID: 15868446
Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.
Christopher R Calabrese, Robert Almassy, +18 authors, Nicola J Curtin.
J Natl Cancer Inst, 2004 Jan 08; 96(1). PMID: 14709739
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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
Marc Audebert, Bernard Salles, Patrick Calsou.
J Biol Chem, 2004 Oct 23; 279(53). PMID: 15498778
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Identification of subtypes in human epidermal growth factor receptor 2--positive breast cancer reveals a gene signature prognostic of outcome.
Johan Staaf, Markus Ringnér, +15 authors, Ake Borg.
J Clin Oncol, 2010 Mar 17; 28(11). PMID: 20231686
Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival.
Scott D Brown, Rene L Warren, +4 authors, Robert A Holt.
Genome Res, 2014 May 02; 24(5). PMID: 24782321    Free PMC article.
Highly Cited.
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Christina Curtis, Sohrab P Shah, +29 authors, Samuel Aparicio.
Nature, 2012 Apr 24; 486(7403). PMID: 22522925    Free PMC article.
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Raising the bar: the curative potential of human cancer immunotherapy.
Steven A Rosenberg.
Sci Transl Med, 2012 Mar 31; 4(127). PMID: 22461638    Free PMC article.
Highly Cited. Review.
Central pathology laboratory review of HER2 and ER in early breast cancer: an ALTTO trial [BIG 2-06/NCCTG N063D (Alliance)] ring study.
Ann E McCullough, Patrizia Dell'orto, +11 authors, Giuseppe Viale.
Breast Cancer Res Treat, 2014 Jan 08; 143(3). PMID: 24395109    Free PMC article.
Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage.
Kiyotsugu Yoshida, Yoshio Miki.
Cancer Sci, 2004 Nov 18; 95(11). PMID: 15546503
Highly Cited. Review.
Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes.
Gunter von Minckwitz, Michael Untch, +14 authors, Sibylle Loibl.
J Clin Oncol, 2012 Apr 18; 30(15). PMID: 22508812
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Hallmarks of 'BRCAness' in sporadic cancers.
Nicholas Turner, Andrew Tutt, Alan Ashworth.
Nat Rev Cancer, 2004 Oct 29; 4(10). PMID: 15510162
Highly Cited. Review.
HER2 and response to paclitaxel in node-positive breast cancer.
Daniel F Hayes, Ann D Thor, +14 authors, Cancer and Leukemia Group B (CALGB) Investigators.
N Engl J Med, 2007 Oct 12; 357(15). PMID: 17928597
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Comprehensive molecular portraits of human breast tumours.
Cancer Genome Atlas Network.
Nature, 2012 Sep 25; 490(7418). PMID: 23000897    Free PMC article.
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TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer.
Steven J Isakoff, Erica L Mayer, +16 authors, Leif W Ellisen.
J Clin Oncol, 2015 Apr 08; 33(17). PMID: 25847936    Free PMC article.
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The landscape of cancer genes and mutational processes in breast cancer.
Philip J Stephens, Patrick S Tarpey, +60 authors, Michael R Stratton.
Nature, 2012 Jun 23; 486(7403). PMID: 22722201    Free PMC article.
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Mutational landscape and significance across 12 major cancer types.
Cyriac Kandoth, Michael D McLellan, +16 authors, Li Ding.
Nature, 2013 Oct 18; 502(7471). PMID: 24132290    Free PMC article.
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Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741.
Marc L Citron, Donald A Berry, +18 authors, Larry Norton.
J Clin Oncol, 2003 Apr 02; 21(8). PMID: 12668651
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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.
Ethan Cerami, Jianjiong Gao, +12 authors, Nikolaus Schultz.
Cancer Discov, 2012 May 17; 2(5). PMID: 22588877    Free PMC article.
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A phase 1b study of trametinib, an oral Mitogen-activated protein kinase kinase (MEK) inhibitor, in combination with gemcitabine in advanced solid tumours.
Jeffrey R Infante, Kyriakos P Papadopoulos, +11 authors, Anthony W Tolcher.
Eur J Cancer, 2013 Apr 16; 49(9). PMID: 23583440
Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer.
Chad J Creighton, Jenny C Chang, Jeffrey M Rosen.
J Mammary Gland Biol Neoplasia, 2010 Apr 01; 15(2). PMID: 20354771
Highly Cited. Review.
Subtype-Specific Metagene-Based Prediction of Outcome after Neoadjuvant and Adjuvant Treatment in Breast Cancer.
Maurizio Callari, Vera Cappelletti, +9 authors, Giampaolo Bianchini.
Clin Cancer Res, 2015 Oct 02; 22(2). PMID: 26423797
The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer.
Robin L Jones, Janine Salter, +5 authors, Mitchell Dowsett.
Breast Cancer Res Treat, 2008 Jul 02; 116(1). PMID: 18592370
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Jordi Barretina, Giordano Caponigro, +58 authors, Levi A Garraway.
Nature, 2012 Mar 31; 483(7391). PMID: 22460905    Free PMC article.
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Predicting response and survival in chemotherapy-treated triple-negative breast cancer.
A Prat, A Lluch, +35 authors, E Alba.
Br J Cancer, 2014 Aug 08; 111(8). PMID: 25101563    Free PMC article.
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival.
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J Clin Invest, 2013 Jun 20; 123(7). PMID: 23778140    Free PMC article.
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High concordance of protein (by IHC), gene (by FISH; HER2 only), and microarray readout (by TargetPrint) of ER, PgR, and HER2: results from the EORTC 10041/BIG 03-04 MINDACT trial.
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Ann Oncol, 2014 Mar 29; 25(4). PMID: 24667714    Free PMC article.
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial.
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Ann Oncol, 2014 Mar 13; 25(8). PMID: 24608200
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Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105.
Melinda L Telli, Kristin C Jensen, +18 authors, James M Ford.
J Clin Oncol, 2015 Apr 08; 33(17). PMID: 25847929    Free PMC article.
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Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer.
William D Foulkes, Ingunn M Stefansson, +5 authors, Lars A Akslen.
J Natl Cancer Inst, 2003 Oct 02; 95(19). PMID: 14519755
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Breast cancer, side population cells and ABCG2 expression.
K M Britton, R Eyre, +4 authors, A P Meeson.
Cancer Lett, 2012 Apr 24; 323(1). PMID: 22521545    Free PMC article.
The secret ally: immunostimulation by anticancer drugs.
Lorenzo Galluzzi, Laura Senovilla, Laurence Zitvogel, Guido Kroemer.
Nat Rev Drug Discov, 2012 Feb 04; 11(3). PMID: 22301798
Highly Cited. Review.
Sequence analysis of mutations and translocations across breast cancer subtypes.
Shantanu Banerji, Kristian Cibulskis, +44 authors, Matthew Meyerson.
Nature, 2012 Jun 23; 486(7403). PMID: 22722202    Free PMC article.
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Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability.
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Cancer Lett, 2001 Feb 13; 163(1). PMID: 11163101
Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98.
Sherene Loi, Nicolas Sirtaine, +13 authors, Christos Sotiriou.
J Clin Oncol, 2013 Jan 24; 31(7). PMID: 23341518
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Association of BRCA1 with Rad51 in mitotic and meiotic cells.
R Scully, J Chen, +5 authors, D M Livingston.
Cell, 1997 Jan 24; 88(2). PMID: 9008167
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Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.
Sylvia Adams, Robert J Gray, +13 authors, Sunil S Badve.
J Clin Oncol, 2014 Jul 30; 32(27). PMID: 25071121    Free PMC article.
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Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
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Emerging landscape of oncogenic signatures across human cancers.
Giovanni Ciriello, Martin L Miller, +3 authors, Chris Sander.
Nat Genet, 2013 Sep 28; 45(10). PMID: 24071851    Free PMC article.
Highly Cited.
A gene expression signature identifies two prognostic subgroups of basal breast cancer.
Renaud Sabatier, Pascal Finetti, +10 authors, François Bertucci.
Breast Cancer Res Treat, 2010 May 22; 126(2). PMID: 20490655
Highly Cited.
The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin.
A Bhattacharyya, U S Ear, +2 authors, D K Bishop.
J Biol Chem, 2000 Jun 14; 275(31). PMID: 10843985
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Hannah Farmer, Nuala McCabe, +11 authors, Alan Ashworth.
Nature, 2005 Apr 15; 434(7035). PMID: 15829967
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BRCA1 dysfunction in sporadic basal-like breast cancer.
N C Turner, J S Reis-Filho, +8 authors, A N Tutt.
Oncogene, 2006 Oct 04; 26(14). PMID: 17016441
Highly Cited.
Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.
Antonio C Wolff, M Elizabeth H Hammond, +19 authors, College of American Pathologists.
J Clin Oncol, 2013 Oct 09; 31(31). PMID: 24101045
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RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells.
Joshua A Bauer, Fei Ye, +5 authors, Jennifer A Pietenpol.
Breast Cancer Res, 2010 Jun 26; 12(3). PMID: 20576088    Free PMC article.
Triple-negative high-risk breast cancer derives particular benefit from dose intensification of adjuvant chemotherapy: results of WSG AM-01 trial.
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Ann Oncol, 2008 Jan 05; 19(5). PMID: 18174609
Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes.
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Clin Cancer Res, 2008 Aug 14; 14(16). PMID: 18698033
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MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
Dai Horiuchi, Leonard Kusdra, +11 authors, Andrei Goga.
J Exp Med, 2012 Mar 21; 209(4). PMID: 22430491    Free PMC article.
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PD-L1 expression in triple-negative breast cancer.
Elizabeth A Mittendorf, Anne V Philips, +14 authors, Gheath Alatrash.
Cancer Immunol Res, 2014 Apr 26; 2(4). PMID: 24764583    Free PMC article.
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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.
Katherine A Hoadley, Christina Yau, +30 authors, Joshua M Stuart.
Cell, 2014 Aug 12; 158(4). PMID: 25109877    Free PMC article.
Highly Cited.
A clinically relevant gene signature in triple negative and basal-like breast cancer.
Achim Rody, Thomas Karn, +11 authors, Manfred Kaufmann.
Breast Cancer Res, 2011 Oct 08; 13(5). PMID: 21978456    Free PMC article.
Highly Cited.
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.
Emmanuelle Charafe-Jauffret, Christophe Ginestier, +15 authors, Max S Wicha.
Cancer Res, 2009 Feb 05; 69(4). PMID: 19190339    Free PMC article.
Highly Cited.
Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up.
L Malorni, P B Shetty, +6 authors, G Arpino.
Breast Cancer Res Treat, 2012 Nov 06; 136(3). PMID: 23124476    Free PMC article.
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
Carsten Denkert, Gunter von Minckwitz, +27 authors, Sibylle Loibl.
J Clin Oncol, 2014 Dec 24; 33(9). PMID: 25534375
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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
T Sørlie, C M Perou, +14 authors, A L Børresen-Dale.
Proc Natl Acad Sci U S A, 2001 Sep 13; 98(19). PMID: 11553815    Free PMC article.
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Basket trials and the evolution of clinical trial design in an era of genomic medicine.
Amanda J Redig, Pasi A Jänne.
J Clin Oncol, 2015 Feb 11; 33(9). PMID: 25667288
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Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance).
William M Sikov, Donald A Berry, +14 authors, Eric P Winer.
J Clin Oncol, 2014 Aug 06; 33(1). PMID: 25092775    Free PMC article.
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Prognostic value of tumor-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: a retrospective multicenter study.
M V Dieci, C Criscitiello, +8 authors, F Andre.
Ann Oncol, 2014 Jan 10; 25(3). PMID: 24401929    Free PMC article.
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American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
M Elizabeth H Hammond, Daniel F Hayes, +29 authors, Antonio C Wolff.
J Clin Oncol, 2010 Apr 21; 28(16). PMID: 20404251    Free PMC article.
Highly Cited. Systematic Review.
Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers.
Giampaolo Bianchini, Yuan Qi, +13 authors, Lajos Pusztai.
J Clin Oncol, 2010 Sep 02; 28(28). PMID: 20805453
Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity.
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Cancer Res, 2013 Feb 19; 73(8). PMID: 23418322    Free PMC article.
TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer.
Neil E Bhola, Justin M Balko, +6 authors, Carlos L Arteaga.
J Clin Invest, 2013 Feb 09; 123(3). PMID: 23391723    Free PMC article.
Highly Cited.
Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Fergus J Couch, Steven N Hart, +38 authors, Peter A Fasching.
J Clin Oncol, 2014 Dec 03; 33(4). PMID: 25452441    Free PMC article.
Highly Cited.
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
A Antoniou, P D P Pharoah, +30 authors, D F Easton.
Am J Hum Genet, 2003 Apr 05; 72(5). PMID: 12677558    Free PMC article.
Highly Cited.
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
Justin M Balko, Jennifer M Giltnane, +24 authors, Carlos L Arteaga.
Cancer Discov, 2013 Dec 21; 4(2). PMID: 24356096    Free PMC article.
Highly Cited.
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Adrian P Wiegmans, Mariska Miranda, +2 authors, Andreas Möller.
Oncotarget, 2016 Aug 11; 7(37). PMID: 27507046    Free PMC article.
Tumor-Specific Peptide, Selected from a Phage Peptide Library, Enhances Antitumor Activity of Lactaptin.
Anna A Nemudraya, Anna A Makartsova, +4 authors, Elena V Kuligina.
PLoS One, 2016 Aug 12; 11(8). PMID: 27513518    Free PMC article.
Adaptive immunity programmes in breast cancer.
Frederick S Varn, David W Mullins, +2 authors, Chao Cheng.
Immunology, 2016 Aug 27; 150(1). PMID: 27564847    Free PMC article.
Identification of novel prognostic indicators for triple-negative breast cancer patients through integrative analysis of cancer genomics data and protein interactome data.
Fan Zhang, Chunyan Ren, +6 authors, Martin J Walsh.
Oncotarget, 2016 Oct 01; 7(44). PMID: 27690302    Free PMC article.
Strategies to avoid treatment-induced lineage crisis in advanced prostate cancer.
Guilhem Roubaud, Bobby C Liaw, William K Oh, David J Mulholland.
Nat Rev Clin Oncol, 2016 Nov 23; 14(5). PMID: 27874061    Free PMC article.
Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis.
Xue Zhu, Ke Wang, +3 authors, Fei Xu.
Int J Mol Sci, 2016 Nov 24; 17(11). PMID: 27879682    Free PMC article.
Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer.
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Mol Biosyst, 2016 Nov 29; 13(1). PMID: 27891540    Free PMC article.
Vitamin D compounds inhibit cancer stem-like cells and induce differentiation in triple negative breast cancer.
Naing Lin Shan, Joseph Wahler, +4 authors, Nanjoo Suh.
J Steroid Biochem Mol Biol, 2016 Dec 08; 173. PMID: 27923595    Free PMC article.
AR-Signaling in Human Malignancies: Prostate Cancer and Beyond.
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Vassiliki Kotoula, Florentia Fostira, +20 authors, George Fountzilas.
Am J Cancer Res, 2017 Jan 27; 7(1). PMID: 28123851    Free PMC article.
Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer.
Marise R Heerma van Voss, Justin D Brilliant, +4 authors, Venu Raman.
Med Oncol, 2017 Feb 01; 34(3). PMID: 28138868    Free PMC article.
Dasatinib inhibits c-src phosphorylation and prevents the proliferation of Triple-Negative Breast Cancer (TNBC) cells which overexpress Syndecan-Binding Protein (SDCBP).
Xiao-Long Qian, Jun Zhang, +7 authors, Li Fu.
PLoS One, 2017 Feb 01; 12(1). PMID: 28141839    Free PMC article.
Non-anthracycline-containing docetaxel and cyclophosphamide regimen is associated with sustained worse outcome compared with docetaxel, anthracycline and cyclophosphamide in neoadjuvant treatment of triple negative and HER2-positive breast cancer patients: updated follow-up data from NATT study.
Xiaosong Chen, Guolin Ye, +2 authors, Kunwei Shen.
Chin J Cancer Res, 2017 Feb 09; 28(6). PMID: 28174484    Free PMC article.
PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer.
Wei Song, Lin Tang, +5 authors, Xiaoxiang Guan.
Sci Rep, 2017 Feb 09; 7. PMID: 28176879    Free PMC article.
Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials.
Alberto J Espay, Michael A Schwarzschild, +13 authors, Anthony E Lang.
Mov Disord, 2017 Feb 25; 32(3). PMID: 28233927    Free PMC article.
P53 and Ki-67 as prognostic markers in triple-negative breast cancer patients.
Yunbao Pan, Yufen Yuan, Guoshi Liu, Yongchang Wei.
PLoS One, 2017 Feb 25; 12(2). PMID: 28235003    Free PMC article.
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Asian Pac J Cancer Prev, 2017 Feb 28; 18(1). PMID: 28240519    Free PMC article.
Down regulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer.
Graciele C M Manica, Caroline F Ribeiro, +12 authors, Giseli Klassen.
Sci Rep, 2017 Mar 16; 7. PMID: 28294120    Free PMC article.
Resistin potentiates chemoresistance and stemness of breast cancer cells: Implications for racially disparate therapeutic outcomes.
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Cancer Lett, 2017 Mar 18; 396. PMID: 28302531    Free PMC article.
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Yue Gong, Yi-Rong Liu, +2 authors, Zhi-Ming Shao.
Sci Rep, 2017 Mar 28; 7. PMID: 28345619    Free PMC article.
Salicylate •Phenanthroline copper (II) complex induces apoptosis in triple-negative breast cancer cells.
Limei Fan, Muyou Tian, +3 authors, Jinhua Xu.
Oncotarget, 2017 Apr 19; 8(18). PMID: 28415735    Free PMC article.
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Highly Cited. Review.
Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors.
Sandra Martínez-Canales, Francisco Cifuentes, +6 authors, Alberto Ocaña.
PLoS One, 2017 May 05; 12(5). PMID: 28472085    Free PMC article.
Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation.
Peiguo Shi, Wenjing Liu, +10 authors, Ceshi Chen.
Cell Discov, 2017 May 10; 3. PMID: 28480051    Free PMC article.
Molecular characterization of circulating tumor cells from patients with metastatic breast cancer reflects evolutionary changes in gene expression under the pressure of systemic therapy.
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Oncotarget, 2017 May 11; 8(28). PMID: 28489591    Free PMC article.
AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer.
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J Exp Clin Cancer Res, 2017 May 13; 36(1). PMID: 28494797    Free PMC article.
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Med Oncol, 2017 May 21; 34(7). PMID: 28526922
ERβ1 inhibits metastasis of androgen receptor-positive triple-negative breast cancer by suppressing ZEB1.
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J Exp Clin Cancer Res, 2017 Jun 07; 36(1). PMID: 28583190    Free PMC article.
Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.
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Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer.
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Sci Transl Med, 2017 Jun 09; 9(393). PMID: 28592566    Free PMC article.
Highly Cited.
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Angelo Paradiso, Christian F Singer.
Breast Care (Basel), 2017 Jun 15; 12(1). PMID: 28611534    Free PMC article.
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Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency.
Masahito Kawazu, Shinya Kojima, +23 authors, Hiroyuki Mano.
PLoS Genet, 2017 Jun 22; 13(6). PMID: 28636652    Free PMC article.
Post-nano strategies for drug delivery: Multistage porous silicon microvectors.
Alessandro Venuta, Joy Wolfram, Haifa Shen, Mauro Ferrari.
J Mater Chem B, 2017 Jul 04; 5(2). PMID: 28670454    Free PMC article.
YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway.
Zekun Chen, Qiuju Wu, +6 authors, Ceshi Chen.
Theranostics, 2017 Jul 26; 7(8). PMID: 28740556    Free PMC article.
Increased Tumour Infiltration of CD4+ and CD8+ T-Lymphocytes in Patients with Triple Negative Breast Cancer Suggests Susceptibility to Immune Therapy
Bushra Sikandar, Muhammad Asif Qureshi, +2 authors, Talat Mirza.
Asian Pac J Cancer Prev, 2017 Jul 28; 18(7). PMID: 28749113    Free PMC article.
Peri-foci adipose-derived stem cells promote chemoresistance in breast cancer.
Wei-Lan Yeh, Cheng-Fang Tsai, Dar-Ren Chen.
Stem Cell Res Ther, 2017 Jul 29; 8(1). PMID: 28750689    Free PMC article.
HIT'nDRIVE: patient-specific multidriver gene prioritization for precision oncology.
Raunak Shrestha, Ermin Hodzic, +8 authors, S Cenk Sahinalp.
Genome Res, 2017 Aug 05; 27(9). PMID: 28768687    Free PMC article.
Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade.
Janet L Martin, Sohel M Julovi, +3 authors, Robert C Baxter.
Breast Cancer Res, 2017 Aug 06; 19(1). PMID: 28778177    Free PMC article.
Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
Sung-Bae Kim, Rebecca Dent, +13 authors, LOTUS investigators.
Lancet Oncol, 2017 Aug 13; 18(10). PMID: 28800861    Free PMC article.
Highly Cited.
Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer.
Nicholas A Taylor, Sarah C Vick, +10 authors, Jonathan S Serody.
J Clin Invest, 2017 Aug 22; 127(9). PMID: 28825599    Free PMC article.
Highly Cited.
A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models.
Mohd Kamil Hussain, Deependra Kumar Singh, +13 authors, Dibyendu Banerjee.
Sci Rep, 2017 Sep 08; 7(1). PMID: 28878282    Free PMC article.
Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer.
Jian Gao, Minmin Fan, +10 authors, Qiang Xu.
Cell Death Dis, 2017 Sep 15; 8(9). PMID: 28906486    Free PMC article.
Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.
Elizabeth A Grossman, Carl C Ward, +5 authors, Daniel K Nomura.
Cell Chem Biol, 2017 Sep 19; 24(11). PMID: 28919038    Free PMC article.
CHST9 rs1436904 genetic variant contributes to prognosis of triple-negative breast cancer.
Jupeng Yuan, Nasha Zhang, +4 authors, Ming Yang.
Sci Rep, 2017 Sep 20; 7(1). PMID: 28924212    Free PMC article.
The Transcriptome of Estrogen-Independent Mammary Growth in Female Mice Reveals That Not All Mammary Glands Are Created Equally.
Grace E Berryhill, Danielle G Lemay, +3 authors, Russell C Hovey.
Endocrinology, 2017 Sep 25; 158(10). PMID: 28938404    Free PMC article.
Crosstalk between stromal components and tumor cells of TNBC via secreted factors enhances tumor growth and metastasis.
Kideok Jin, Niranjan B Pandey, Aleksander S Popel.
Oncotarget, 2017 Sep 28; 8(36). PMID: 28947965    Free PMC article.
Identification of candidate genes associated with triple negative breast cancer.
Audrey Player, Nissi Abraham, +6 authors, Wiley Walls.
Genes Cancer, 2017 Oct 03; 8(7-8). PMID: 28966727    Free PMC article.
Canine invasive mammary carcinomas as models of human breast cancer. Part 2: immunophenotypes and prognostic significance.
Jérôme Abadie, Frédérique Nguyen, +8 authors, Mario Campone.
Breast Cancer Res Treat, 2017 Oct 25; 167(2). PMID: 29063312    Free PMC article.
Estrogen receptor β2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1α.
Lucia Bialesova, Li Xu, +3 authors, Karin Dahlman-Wright.
Oncotarget, 2017 Nov 05; 8(44). PMID: 29100336    Free PMC article.
Network-pharmacology-based validation of TAMS/CXCL-1 as key mediator of XIAOPI formula preventing breast cancer development and metastasis.
Neng Wang, Yifeng Zheng, +7 authors, Zhiyu Wang.
Sci Rep, 2017 Nov 08; 7(1). PMID: 29109519    Free PMC article.
Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways.
Pablo Garrido, Aliaa Shalaby, +8 authors, Sharon A Glynn.
Oncotarget, 2017 Nov 09; 8(46). PMID: 29113326    Free PMC article.
Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer.
Melissa Quintero, Douglas Adamoski, +6 authors, Sandra Martha Gomes Dias.
BMC Cancer, 2017 Nov 09; 17(1). PMID: 29115931    Free PMC article.
The role of BRCA status on prognosis in patients with triple-negative breast cancer.
Yuxin Xie, Qiheng Gou, +2 authors, Hong Zheng.
Oncotarget, 2017 Nov 21; 8(50). PMID: 29152070    Free PMC article.
Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance.
Sheng-Yen Lin, Sung-Yuan Hsieh, +5 authors, Ning-Sun Yang.
Autophagy, 2017 Nov 25; 14(5). PMID: 29171784    Free PMC article.
Novel chimeric parapoxvirus CF189 as an oncolytic immunotherapy in triple-negative breast cancer.
Audrey H Choi, Michael P O'Leary, +4 authors, Nanhai G Chen.
Surgery, 2017 Nov 28; 163(2). PMID: 29174433    Free PMC article.
Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.
Hui Liu, Charles J Murphy, +6 authors, Lewis C Cantley.
Cancer Discov, 2017 Dec 06; 8(3). PMID: 29203461    Free PMC article.
Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology.
James R W Conway, Claire Vennin, +11 authors, Paul Timpson.
Sci Rep, 2017 Dec 06; 7(1). PMID: 29203823    Free PMC article.
Complete regression of cutaneous metastases with systemic immune response in a patient with triple negative breast cancer receiving p53MVA vaccine with pembrolizumab.
Yuan Yuan, Ferdynand J Kos, +9 authors, Don J Diamond.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209571    Free PMC article.
Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer.
Lina Liu, Yuhua Wang, +4 authors, Leaf Huang.
Mol Ther, 2017 Dec 21; 26(1). PMID: 29258739    Free PMC article.
MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer.
Takahiro Maeda, Masayuki Hiraki, +10 authors, Donald Kufe.
Cancer Res, 2017 Dec 22; 78(1). PMID: 29263152    Free PMC article.
Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer.
Daniel G Stover, Heather A Parsons, +20 authors, Viktor A Adalsteinsson.
J Clin Oncol, 2018 Jan 04; 36(6). PMID: 29298117    Free PMC article.
Highly Cited.
Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.
Sergey V Kozin, Nir Maimon, +4 authors, Igor Garkavtsev.
Oncotarget, 2018 Jan 10; 8(65). PMID: 29312532    Free PMC article.
Downregulation of miR-221-3p and upregulation of its target gene PARP1 are prognostic biomarkers for triple negative breast cancer patients and associated with poor prognosis.
Ling Deng, Qianqian Lei, +9 authors, Hong Zheng.
Oncotarget, 2018 Jan 10; 8(65). PMID: 29312562    Free PMC article.
MiR-770 suppresses the chemo-resistance and metastasis of triple negative breast cancer via direct targeting of STMN1.
Yaming Li, Yiran Liang, +5 authors, Qifeng Yang.
Cell Death Dis, 2018 Jan 13; 9(1). PMID: 29323124    Free PMC article.
PITX2 DNA-methylation predicts response to anthracycline-based adjuvant chemotherapy in triple-negative breast cancer patients.
Magdalena Absmaier, Rudolf Napieralski, +9 authors, Manfred Schmitt.
Int J Oncol, 2018 Jan 13; 52(3). PMID: 29328369    Free PMC article.
Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1.
Rong Liu, Xu Zhi, +4 authors, Ceshi Chen.
Sci Rep, 2018 Jan 20; 8(1). PMID: 29348684    Free PMC article.
Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.
Federico Lucantoni, Andreas U Lindner, +2 authors, Jochen H M Prehn.
Cell Death Dis, 2018 Jan 21; 9(2). PMID: 29352235    Free PMC article.
Unravelling triple-negative breast cancer molecular heterogeneity using an integrative multiomic analysis.
Y Bareche, D Venet, +4 authors, C Sotiriou.
Ann Oncol, 2018 Jan 25; 29(4). PMID: 29365031    Free PMC article.
Highly Cited.
Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells.
Ana Cano-González, Marta Mauro-Lizcano, +2 authors, Abelardo López-Rivas.
Cell Death Dis, 2018 Jan 28; 9(2). PMID: 29374147    Free PMC article.
Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer.
Haolong Li, Lei Liu, +2 authors, Da Xing.
Cell Death Dis, 2018 Jan 28; 9(2). PMID: 29374168    Free PMC article.
Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.
Amanda Tomie Ouchida, Yingbo Li, +5 authors, Junying Yuan.
Cell Death Dis, 2018 Jan 28; 9(2). PMID: 29374185    Free PMC article.
Schedule dependent synergy of gemcitabine and doxorubicin: Improvement of in vitro efficacy and lack of in vitro-in vivo correlation.
Douglas R Vogus, Anusha Pusuluri, Renwei Chen, Samir Mitragotri.
Bioeng Transl Med, 2018 Jan 30; 3(1). PMID: 29376133    Free PMC article.
Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo.
Marta Sesé, Pedro Fuentes, +5 authors, Santiago Ramón Y Cajal.
Oncotarget, 2018 Feb 01; 8(70). PMID: 29383126    Free PMC article.
A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo.
Elisabetta Bolli, John P O'Rourke, +7 authors, Federica Cavallo.
Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399412    Free PMC article.
Three-dimensional tumor model mimics stromal - breast cancer cells signaling.
Stephanie Lemmo Ham, Pradip Shahi Thakuri, +4 authors, Hossein Tavana.
Oncotarget, 2018 Feb 09; 9(1). PMID: 29416611    Free PMC article.
Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells.
Marta Mauro-Lizcano, Abelardo López-Rivas.
Cell Death Dis, 2018 Feb 13; 9(2). PMID: 29434187    Free PMC article.
MiR-539 inhibits proliferation and migration of triple-negative breast cancer cells by down-regulating LAMA4 expression.
Zhi-Xue Yang, Bo Zhang, +4 authors, Chun-Gen Xing.
Cancer Cell Int, 2018 Feb 13; 18. PMID: 29434522    Free PMC article.
Leptin Signaling Mediates Obesity-Associated CSC Enrichment and EMT in Preclinical TNBC Models.
Laura W Bowers, Emily L Rossi, +7 authors, Stephen D Hursting.
Mol Cancer Res, 2018 Feb 18; 16(5). PMID: 29453319    Free PMC article.
Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer.
Mingshan Liu, Yang Liu, +6 authors, Suling Liu.
Mol Cancer, 2018 Feb 24; 17(1). PMID: 29471829    Free PMC article.
A hierarchical prognostic model for risk stratification in patients with early breast cancer according to 18 F-fludeoxyglucose uptake and clinicopathological parameters.
Jongtae Cha, Hyung Seok Park, +4 authors, Mijin Yun.
Cancer Med, 2018 Feb 27; 7(4). PMID: 29479851    Free PMC article.
Breast cancer cell-derived exosomes and macrophage polarization are associated with lymph node metastasis.
Yin Ji Piao, Hoe Suk Kim, +3 authors, Woo Kyung Moon.
Oncotarget, 2018 Feb 28; 9(7). PMID: 29484119    Free PMC article.
Molecular Mechanisms and Emerging Therapeutic Targets of Triple-Negative Breast Cancer Metastasis.
Christiana Neophytou, Panagiotis Boutsikos, Panagiotis Papageorgis.
Front Oncol, 2018 Mar 10; 8. PMID: 29520340    Free PMC article.
Highly Cited. Review.
Timosaponin A-III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells.
Joseph E Gergely, Armond E Dorsey, Goberdhan P Dimri, Manjari Dimri.
Mol Carcinog, 2018 Mar 13; 57(7). PMID: 29528145    Free PMC article.
A usable model of "decathlon winner" cancer cells in triple-negative breast cancer: survival of resistant cancer cells in quiescence.
Balraj Singh, Vanessa N Sarli, +2 authors, Anthony Lucci.
Oncotarget, 2018 Mar 16; 9(13). PMID: 29541397    Free PMC article.
The ERβ4 variant induces transformation of the normal breast mammary epithelial cell line MCF-10A; the ERβ variants ERβ2 and ERβ5 increase aggressiveness of TNBC by regulation of hypoxic signaling.
Michelle Faria, Samaneh Karami, +8 authors, Jan-Åke Gustafsson.
Oncotarget, 2018 Mar 20; 9(15). PMID: 29552303    Free PMC article.
212Pb-Labeled Antibody 225.28 Targeted to Chondroitin Sulfate Proteoglycan 4 for Triple-Negative Breast Cancer Therapy in Mouse Models.
Benjamin B Kasten, Patsy G Oliver, +4 authors, Donald J Buchsbaum.
Int J Mol Sci, 2018 Mar 22; 19(4). PMID: 29561763    Free PMC article.
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.
Amritha Nair, Hsiang-Ching Chung, +34 authors, Thomas F Westbrook.
Nat Med, 2018 Mar 27; 24(4). PMID: 29578538    Free PMC article.
Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis.
Linjie Zhao, Shuang Huang, +16 authors, Shengtao Zhou.
Proc Natl Acad Sci U S A, 2018 Mar 30; 115(16). PMID: 29592953    Free PMC article.
The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells.
Susana P Egusquiaguirre, Jennifer E Yeh, +2 authors, David A Frank.
Neoplasia, 2018 Apr 06; 20(5). PMID: 29621649    Free PMC article.
Nuclear Insulin-Like Growth Factor Binding Protein-3 As a Biomarker in Triple-Negative Breast Cancer Xenograft Tumors: Effect of Targeted Therapy and Comparison With Chemotherapy.
Sohel M Julovi, Janet L Martin, Robert C Baxter.
Front Endocrinol (Lausanne), 2018 Apr 07; 9. PMID: 29623068    Free PMC article.
A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks.
Xuezhong Zhou, Lei Lei, +9 authors, Zhong Wang.
EBioMedicine, 2018 Apr 20; 31. PMID: 29669699    Free PMC article.
Postmastectomy radiotherapy reduces locoregional and disease recurrence in patients with stage II-III triple-negative breast cancer treated with neoadjuvant chemotherapy and mastectomy.
Xingxing Chen, Fan Xia, +7 authors, Xiaomao Guo.
Onco Targets Ther, 2018 Apr 20; 11. PMID: 29670372    Free PMC article.
Mammary Stem Cells and Breast Cancer Stem Cells: Molecular Connections and Clinical Implications.
Toni Celià-Terrassa.
Biomedicines, 2018 May 08; 6(2). PMID: 29734696    Free PMC article.
Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor-κB Activation.
Wei Wang, Bo Zhang, +4 authors, Zhao-Hui Wu.
J Pharmacol Exp Ther, 2018 May 08; 366(1). PMID: 29735611    Free PMC article.
(-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer.
Joan Crous-Masó, Sònia Palomeras, +5 authors, Teresa Puig.
Molecules, 2018 May 13; 23(5). PMID: 29751678    Free PMC article.
LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling.
Jianming Tang, Yanxin Li, +4 authors, Haizhong Feng.
Oncogene, 2018 May 16; 37(34). PMID: 29760406
Highly Cited.
Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer.
Masayuki Hiraki, Takahiro Maeda, +9 authors, Donald Kufe.
Signal Transduct Target Ther, 2018 May 16; 3. PMID: 29760958    Free PMC article.
How shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies.
Ji Hyun Park, Jin-Hee Ahn, Sung-Bae Kim.
ESMO Open, 2018 May 17; 3(Suppl 1). PMID: 29765774    Free PMC article.
Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro.
Rodolfo Garza-Morales, Roxana Gonzalez-Ramos, +4 authors, Jorge G Gomez-Gutierrez.
Cancers (Basel), 2018 May 19; 10(5). PMID: 29772755    Free PMC article.
Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer.
Emily E Bosco, R James Christie, +20 authors, David A Tice.
Oncotarget, 2018 May 26; 9(33). PMID: 29796165    Free PMC article.
Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer.
Wei Li, Takashi Tanikawa, +15 authors, Weiping Zou.
Cell Metab, 2018 May 29; 28(1). PMID: 29805099    Free PMC article.
Highly Cited.
LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers.
Sylvie Maubant, Tania Tahtouh, +16 authors, Thierry Dubois.
Oncotarget, 2018 Jun 02; 9(32). PMID: 29854300    Free PMC article.
Addressing the challenges of applying precision oncology.
Seung Ho Shin, Ann M Bode, Zigang Dong.
NPJ Precis Oncol, 2018 Jun 07; 1(1). PMID: 29872710    Free PMC article.
The neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict efficacy of platinum-based chemotherapy in patients with metastatic triple negative breast cancer.
Claudio Vernieri, Alessia Mennitto, +12 authors, Filippo de Braud.
Sci Rep, 2018 Jun 09; 8(1). PMID: 29880896    Free PMC article.
Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer.
Rachel Brough, Aditi Gulati, +6 authors, Christopher J Lord.
Oncogene, 2018 Jun 20; 37(43). PMID: 29915391    Free PMC article.
Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer.
Sung-Young Shin, Anna-Katharina Müller, +2 authors, Lan K Nguyen.
PLoS Comput Biol, 2018 Jun 20; 14(6). PMID: 29920512    Free PMC article.
Chemotherapy Sensitizes Therapy-Resistant Cells to Mild Hyperthermia by Suppressing Heat Shock Protein 27 Expression in Triple-Negative Breast Cancer.
Chaofeng Mu, Xiaoyan Wu, +9 authors, Haifa Shen.
Clin Cancer Res, 2018 Jun 21; 24(19). PMID: 29921732    Free PMC article.
Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition.
Aniket V Mali, Asavari A Joshi, Mahabaleshwar V Hegde, Shivajirao S Kadam.
Cancer Biol Med, 2018 Jun 29; 15(2). PMID: 29951338    Free PMC article.
B7-H4 overexpression contributes to poor prognosis and drug-resistance in triple-negative breast cancer.
Ling Wang, Chao Yang, +2 authors, Fu-Biao Kang.
Cancer Cell Int, 2018 Jul 17; 18. PMID: 30008617    Free PMC article.
Identification of long non-coding RNA signatures in triple-negative breast cancer.
Tian Tian, Zhouqing Gong, +10 authors, Zhijun Dai.
Cancer Cell Int, 2018 Jul 22; 18. PMID: 30026672    Free PMC article.
Blocking LLT1 (CLEC2D, OCIL)-NKRP1A (CD161) interaction enhances natural killer cell-mediated lysis of triple-negative breast cancer cells.
Armando M Marrufo, Stephen O Mathew, +3 authors, Porunelloor A Mathew.
Am J Cancer Res, 2018 Jul 24; 8(6). PMID: 30034942    Free PMC article.
Progress in the treatment of solid tumors with apatinib: a systematic review.
Deze Zhao, Helei Hou, Xiaochun Zhang.
Onco Targets Ther, 2018 Jul 28; 11. PMID: 30050305    Free PMC article.
Targeting the cell cycle in breast cancer: towards the next phase.
K L Thu, I Soria-Bretones, T W Mak, D W Cescon.
Cell cycle (Georgetown, Tex.), 2018 Aug 07; 17(15). PMID: 30078354    Free PMC article.
Integrative analysis of the inter-tumoral heterogeneity of triple-negative breast cancer.
Alec M Chiu, Mithun Mitra, Lari Boymoushakian, Hilary A Coller.
Sci Rep, 2018 Aug 09; 8(1). PMID: 30087365    Free PMC article.
Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer.
Sandra L Romero-Cordoba, Sergio Rodriguez-Cuevas, +6 authors, Alfredo Hidalgo-Miranda.
Sci Rep, 2018 Aug 18; 8(1). PMID: 30115973    Free PMC article.
Downregulation of Dock1 and Elmo1 suppresses the migration and invasion of triple-negative breast cancer epithelial cells through the RhoA/Rac1 pathway.
Yueyang Liang, Shushu Wang, Yi Zhang.
Oncol Lett, 2018 Aug 22; 16(3). PMID: 30127952    Free PMC article.
Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2.
Matthew Tegowski, Cheng Fan, Albert S Baldwin.
J Biol Chem, 2018 Aug 23; 293(41). PMID: 30131338    Free PMC article.
The Androgen Receptor in Breast Cancer.
Pia Giovannelli, Marzia Di Donato, +3 authors, Antimo Migliaccio.
Front Endocrinol (Lausanne), 2018 Sep 14; 9. PMID: 30210453    Free PMC article.
Highly Cited. Review.
MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers.
Ilaria Plantamura, Giulia Cosentino, Alessandra Cataldo.
Front Oncol, 2018 Sep 21; 8. PMID: 30234015    Free PMC article.
The "Yin and Yang" of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers.
Elizabeth Varghese, Samson Mathews Samuel, +3 authors, Dietrich Büsselberg.
Cancers (Basel), 2018 Sep 27; 10(10). PMID: 30248941    Free PMC article.
Loss of mdig expression enhances DNA and histone methylation and metastasis of aggressive breast cancer.
Chitra Thakur, Bailing Chen, +3 authors, Fei Chen.
Signal Transduct Target Ther, 2018 Sep 27; 3. PMID: 30254753    Free PMC article.
Hypoxia Induces the Acquisition of Cancer Stem-like Phenotype Via Upregulation and Activation of Signal Transducer and Activator of Transcription-3 (STAT3) in MDA-MB-231, a Triple Negative Breast Cancer Cell Line.
Hoda Soleymani Abyaneh, Nidhi Gupta, +3 authors, Raymond Lai.
Cancer Microenviron, 2018 Sep 27; 11(2-3). PMID: 30255421    Free PMC article.
The antipsychotic agent trifluoperazine hydrochloride suppresses triple-negative breast cancer tumor growth and brain metastasis by inducing G0/G1 arrest and apoptosis.
Zhanzhan Feng, Yong Xia, +13 authors, Luoting Yu.
Cell Death Dis, 2018 Sep 28; 9(10). PMID: 30258182    Free PMC article.
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.
Yixiao Feng, Mia Spezia, +15 authors, Guosheng Ren.
Genes Dis, 2018 Sep 28; 5(2). PMID: 30258937    Free PMC article.
Highly Cited. Review.
High Cytoplasmic CXCR4 Expression Predicts Prolonged Survival in Triple-Negative Breast Cancer Patients Treated with Adjuvant Chemotherapy.
Bobae Shim, Min-Sun Jin, +2 authors, Han Suk Ryu.
J Pathol Transl Med, 2018 Oct 03; 52(6). PMID: 30269472    Free PMC article.
ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer.
Sushil Kumar, David W Wilkes, +7 authors, Rumela Chakrabarti.
J Clin Invest, 2018 Oct 09; 128(11). PMID: 30295647    Free PMC article.
Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers.
Goodwin G Jinesh, Elsa R Flores, Andrew S Brohl.
PLoS One, 2018 Oct 20; 13(10). PMID: 30335837    Free PMC article.
New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer.
Deborah Agostini, Valentina Natalucci, +9 authors, Elena Barbieri.
Oxid Med Cell Longev, 2018 Oct 27; 2018. PMID: 30363988    Free PMC article.
RPLP1 promotes tumor metastasis and is associated with a poor prognosis in triple-negative breast cancer patients.
Zhixian He, Qian Xu, +6 authors, Zhimin Shao.
Cancer Cell Int, 2018 Nov 06; 18. PMID: 30386179    Free PMC article.
Ixazomib in combination with carboplatin in pretreated women with advanced triple-negative breast cancer, a phase I/II trial of the AGMT (AGMT MBC-10 trial).
Gabriel Rinnerthaler, Simon Peter Gampenrieder, +13 authors, Richard Greil.
BMC Cancer, 2018 Nov 08; 18(1). PMID: 30400780    Free PMC article.
Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways.
Marina Cruz-Lozano, Adrián González-González, +10 authors, Sergio Granados-Principal.
Eur J Nutr, 2018 Nov 22; 58(8). PMID: 30460610
Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells.
Yen-Dun Tony Tzeng, Pei-Feng Liu, +8 authors, Chih-Wen Shu.
Front Pharmacol, 2018 Nov 27; 9. PMID: 30473665    Free PMC article.
Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.
Peng Huang, Deng-Jie Ouyang, +9 authors, Wen-Jun Yi.
Cell Commun Signal, 2018 Dec 01; 16(1). PMID: 30497491    Free PMC article.
AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer.
Kaiming Zhang, Peng Liu, +5 authors, Xiangsheng Xiao.
Front Pharmacol, 2018 Dec 07; 9. PMID: 30505272    Free PMC article.
LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA.
Jianming Tang, Guangsheng Zhong, +11 authors, Aihong Bi.
Cell Death Dis, 2018 Dec 07; 9(12). PMID: 30518934    Free PMC article.
Incidence and Survival Outcomes of Breast Cancer with Synchronous Hepatic Metastases: A Population-Based Study.
Weikai Xiao, Shaoquan Zheng, +5 authors, Xiaoming Xie.
J Cancer, 2018 Dec 07; 9(23). PMID: 30519334    Free PMC article.
Rapid Synthesis of N-Tosylhydrazones under Solvent-Free Conditions and Their Potential Application Against Human Triple-Negative Breast Cancer.
Zengyang Xie, Yuying Song, +5 authors, Xue Liu.
ChemistryOpen, 2018 Dec 14; 7(12). PMID: 30524923    Free PMC article.
Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling.
Jun-Jian Wang, June X Zou, +6 authors, Hong-Wu Chen.
Acta Pharmacol Sin, 2019 Jan 24; 40(8). PMID: 30670815    Free PMC article.
Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression.
Juan J Arroyo-Crespo, Ana Armiñán, +6 authors, María J Vicent.
Int J Cancer, 2019 Mar 13; 145(8). PMID: 30860605    Free PMC article.
Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer.
Jichao He, Ronan P McLaughlin, +5 authors, Bob van de Water.
Breast Cancer Res Treat, 2019 Aug 08; 178(2). PMID: 31388935    Free PMC article.
FKBP12 is a predictive biomarker for efficacy of anthracycline-based chemotherapy in breast cancer.
Mingyou Xing, Jun Wang, +4 authors, Sheng Zhou.
Cancer Chemother Pharmacol, 2019 Aug 21; 84(4). PMID: 31428819    Free PMC article.
Role of the Microenvironment in Regulating Normal and Cancer Stem Cell Activity: Implications for Breast Cancer Progression and Therapy Response.
Vasudeva Bhat, Alison L Allan, Afshin Raouf.
Cancers (Basel), 2019 Aug 28; 11(9). PMID: 31450577    Free PMC article.
Tumor-infiltrating lymphocytes and CD8+ T cells predict survival of triple-negative breast cancer.
H Vihervuori, T A Autere, +5 authors, P Kronqvist.
J Cancer Res Clin Oncol, 2019 Sep 29; 145(12). PMID: 31562550    Free PMC article.
Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells.
Chaobing Ma, Xueyin Zu, +4 authors, Dong Joon Kim.
Mol Cells, 2019 Sep 30; 42(9). PMID: 31564074    Free PMC article.
TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway.
Weiguang Liu, Jianjun Han, +2 authors, Jianchao He.
Cancer Cell Int, 2019 Oct 02; 19. PMID: 31572059    Free PMC article.
New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription.
Ming-Hao Hu, Tian-Ying Wu, Qiong Huang, Guangyi Jin.
Nucleic Acids Res, 2019 Oct 05; 47(20). PMID: 31584090    Free PMC article.
Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling.
Byung-Hak Kim, Eun Hee Yi, +3 authors, Sang-Kyu Ye.
J Breast Cancer, 2019 Oct 11; 22(3). PMID: 31598337    Free PMC article.
Inhibition of miRNA-34a promotes triple negative cancer cell proliferation by promoting glucose uptake.
Zhen Li, Xiaoxuan Gong, +5 authors, Jinhai Tang.
Exp Ther Med, 2019 Oct 17; 18(5). PMID: 31616515    Free PMC article.
Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway.
Xiaohong Xu, Vinothkumar Rajamanickam, +7 authors, Yi Wang.
Drug Des Devel Ther, 2019 Oct 22; 13. PMID: 31631978    Free PMC article.
Recent Advances in Nuclear Imaging of Receptor Expression to Guide Targeted Therapies in Breast Cancer.
Barbara Salvatore, Maria Grazia Caprio, +3 authors, Antonella Zannetti.
Cancers (Basel), 2019 Oct 28; 11(10). PMID: 31652624    Free PMC article.
Overexpression of MiR-146a-5p Upregulates lncRNA HOTAIR in Triple-Negative Breast Cancer Cells and Predicts Poor Prognosis.
Hongguang Liang, Weihua Huang, +2 authors, Lixian Zeng.
Technol Cancer Res Treat, 2019 Nov 02; 18. PMID: 31672084    Free PMC article.
The Modulatory Properties of Astragalus membranaceus Treatment on Triple-Negative Breast Cancer: An Integrated Pharmacological Method.
Cun Liu, Kejia Wang, +10 authors, Changgang Sun.
Front Pharmacol, 2019 Nov 05; 10. PMID: 31680955    Free PMC article.
Improving breast cancer sensitivity to paclitaxel by increasing aneuploidy.
Sylvie Rodrigues-Ferreira, Anne Nehlig, +13 authors, Clara Nahmias.
Proc Natl Acad Sci U S A, 2019 Nov 07; 116(47). PMID: 31685623    Free PMC article.
Pattern of Presentation of Patients With Breast Cancer in Iraq in 2018: A Cross-Sectional Study.
Mohammed Tareq Mutar, Mohammed Saleh Goyani, Ali Mohammed Had, Aqeel Shakir Mahmood.
J Glob Oncol, 2019 Nov 14; 5. PMID: 31721627    Free PMC article.
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.
Giada Zurlo, Xijuan Liu, +18 authors, Qing Zhang.
Nat Commun, 2019 Nov 16; 10(1). PMID: 31729379    Free PMC article.
Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer.
Chengxiang Zhang, Xinfu Zhang, +9 authors, Yizhou Dong.
Nano Res, 2019 Nov 19; 12(4). PMID: 31737223    Free PMC article.
MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment.
Lei Bian, Yiling Meng, Meichao Zhang, Dong Li.
Mol Cancer, 2019 Nov 27; 18(1). PMID: 31767017    Free PMC article.
High expression of NR1D1 is associated with good prognosis in triple-negative breast cancer patients treated with chemotherapy.
Hyelin Na, Jinil Han, +4 authors, Mi-Ock Lee.
Breast Cancer Res, 2019 Nov 30; 21(1). PMID: 31779659    Free PMC article.
Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.
Sourav Banerjee, Tiantian Wei, +17 authors, Xiaoguang Lei.
Proc Natl Acad Sci U S A, 2019 Nov 23; 116(49). PMID: 31754034    Free PMC article.
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription.
Jin-Mei Yu, Wei Sun, +17 authors, Zhuo-Wei Hu.
Nat Commun, 2019 Dec 18; 10(1). PMID: 31844113    Free PMC article.
The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells.
Can Luo, Yu Wang, +2 authors, Zhaoning Ji.
Exp Ther Med, 2019 Dec 20; 19(1). PMID: 31853299    Free PMC article.
Development of Oxadiazole-Based ODZ10117 as a Small-Molecule Inhibitor of STAT3 for Targeted Cancer Therapy.
Byung-Hak Kim, Haeri Lee, +7 authors, Sang-Kyu Ye.
J Clin Med, 2019 Nov 07; 8(11). PMID: 31684051    Free PMC article.
MiR-210 Is Overexpressed in Tumor-infiltrating Plasma Cells in Triple-negative Breast Cancer.
Isabelle Bar, Ivan Theate, +5 authors, Ahmad Merhi.
J Histochem Cytochem, 2019 Dec 04; 68(1). PMID: 31787032    Free PMC article.
Long Noncoding RNA DCST1-AS1 Promotes Cell Proliferation and Metastasis in Triple-negative Breast Cancer by Forming a Positive Regulatory Loop with miR-873-5p and MYC.
Li Tang, Yuli Chen, +3 authors, Feng Yan.
J Cancer, 2020 Jan 04; 11(2). PMID: 31897227    Free PMC article.
Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer.
Chang-Ching Lin, Miao-Chia Lo, +7 authors, Duxin Sun.
Cancer Lett, 2018 Sep 19; 438. PMID: 30227220    Free PMC article.
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy.
Caroline K Søgaard, Anala Nepal, +4 authors, Marit Otterlei.
Oncotarget, 2020 Jan 11; 10(68). PMID: 31921382    Free PMC article.
CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1.
Weikai Xiao, Shaoquan Zheng, +4 authors, Xiaoming Xie.
Aging (Albany NY), 2019 Dec 21; 11(24). PMID: 31857500    Free PMC article.
Comparing MicroRNA Profilings of Purified HER-2-Negative and HER-2-Positive Cells Validates miR-362-5p/Sema3A as Characteristic Molecular Change in Triple-Negative Breast Cancers.
Xiaoqing Zhang, Qi He, +4 authors, Jianfeng Wang.
Dis Markers, 2020 Jan 14; 2019. PMID: 31929841    Free PMC article.
Current shreds of evidence on the anticancer role of EGCG in triple negative breast cancer: an update of the current state of knowledge.
Sabrina Bimonte, Marco Cascella, +2 authors, Arturo Cuomo.
Infect Agent Cancer, 2020 Jan 16; 15. PMID: 31938038    Free PMC article.
The prognostic and predictive potential of Ki-67 in triple-negative breast cancer.
Xiuzhi Zhu, Li Chen, +8 authors, Zhonghua Wang.
Sci Rep, 2020 Jan 16; 10(1). PMID: 31937819    Free PMC article.
The discordance pattern of molecular sub-types between primary and metastatic sites in Chinese breast cancer patients.
Gaoda Ju, Rongxuan Zhu, +9 authors, Hongxia Wang.
Int J Clin Exp Pathol, 2020 Jan 18; 11(12). PMID: 31949681    Free PMC article.
MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance and Applications in Human Triple-Negative Breast Cancer.
Lei Ding, Huan Gu, +6 authors, Qinghua Cui.
Cells, 2019 Nov 27; 8(12). PMID: 31766744    Free PMC article.
Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.
Sameer S Chopra, Anne Jenney, +10 authors, Peter K Sorger.
Cell Syst, 2019 Dec 10; 10(1). PMID: 31812693    Free PMC article.
Quantification of HER1, HER2 and HER3 by time-resolved Förster resonance energy transfer in FFPE triple-negative breast cancer samples.
Alexandre Ho-Pun-Cheung, Hervé Bazin, +10 authors, Evelyne Lopez-Crapez.
Br J Cancer, 2019 Dec 04; 122(3). PMID: 31792349    Free PMC article.
A Novel Bioengineered miR-127 Prodrug Suppresses the Growth and Metastatic Potential of Triple-Negative Breast Cancer Cells.
Maxine Umeh-Garcia, Catalina Simion, +5 authors, Colleen Sweeney.
Cancer Res, 2019 Nov 07; 80(3). PMID: 31694904    Free PMC article.
Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis.
Rong Liu, Haijun Chen, +7 authors, Ceshi Chen.
Int J Biol Sci, 2020 Feb 07; 16(4). PMID: 32025209    Free PMC article.
Schlafen12 Reduces the Aggressiveness of Triple Negative Breast Cancer through Post-Transcriptional Regulation of ZEB1 That Drives Stem Cell Differentiation.
Sarmad Al-Marsoummi, Emilie Vomhof-DeKrey, Marc D Basson.
Cell Physiol Biochem, 2019 Dec 16; 53(6). PMID: 31838790    Free PMC article.
G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer.
Magdalena Dragan, Mai-Uyen Nguyen, +14 authors, Moshmi Bhattacharya.
Cell Death Dis, 2020 Feb 09; 11(2). PMID: 32034133    Free PMC article.
Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer.
Nan Shao, Yawei Shi, +5 authors, Ying Lin.
Int J Biol Sci, 2019 Jun 12; 15(5). PMID: 31182917    Free PMC article.
Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer.
Stephanie Metcalf, Susan Dougherty, +4 authors, Brian F Clem.
Clin Exp Metastasis, 2019 Oct 21; 37(1). PMID: 31630284
CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer.
Qianqian Zheng, Jian Gao, +4 authors, Chenghai Zhao.
Cancer Sci, 2019 Dec 13; 111(2). PMID: 31830330    Free PMC article.
Saikosaponin A Inhibits Triple-Negative Breast Cancer Growth and Metastasis Through Downregulation of CXCR4.
Ying Wang, Liang Zhao, +8 authors, Qiangli Wang.
Front Oncol, 2020 Feb 13; 9. PMID: 32047724    Free PMC article.
Comprehensive Proteomic Characterization Reveals Subclass-Specific Molecular Aberrations within Triple-negative Breast Cancer.
Max Kosok, Asfa Alli-Shaik, Boon Huat Bay, Jayantha Gunaratne.
iScience, 2020 Feb 15; 23(2). PMID: 32058975    Free PMC article.
SIX4 promotes metastasis through STAT3 activation in breast cancer.
Xuling Sun, Jin Ma, +6 authors, Zhixin Cao.
Am J Cancer Res, 2020 Feb 18; 10(1). PMID: 32064163    Free PMC article.
TAK1 signaling regulates p53 through a mechanism involving ribosomal stress.
Justin Zonneville, Vincent Wong, +2 authors, Andrei V Bakin.
Sci Rep, 2020 Feb 15; 10(1). PMID: 32054925    Free PMC article.
RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2.
Yin-Long Yang, Ye Zhang, +10 authors, Zhi-Min Shao.
Cell Death Differ, 2019 Aug 14; 27(3). PMID: 31406303    Free PMC article.
Detecting heterogeneity in and between breast cancer cell lines.
Yang Shen, B U Sebastian Schmidt, +4 authors, Wolfgang Losert.
Cancer Converg, 2020 Feb 25; 4(1). PMID: 32090168    Free PMC article.
Three-dimensional radiomics of triple-negative breast cancer: Prediction of systemic recurrence.
Jieun Koh, Eunjung Lee, +5 authors, Hee Jung Moon.
Sci Rep, 2020 Feb 23; 10(1). PMID: 32076078    Free PMC article.
Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC.
Renbo Tan, Haoyang Li, +4 authors, Ying Xu.
Sci Rep, 2020 Feb 23; 10(1). PMID: 32080331    Free PMC article.
The Roles of CD38 and CD157 in the Solid Tumor Microenvironment and Cancer Immunotherapy.
Yu Jun Wo, Adelia Shin Ping Gan, +4 authors, Joe Poh Sheng Yeong.
Cells, 2019 Dec 22; 9(1). PMID: 31861847    Free PMC article.
Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer.
Felix Meyer, Saskia Becker, +10 authors, Kerstin Borgmann.
Cells, 2020 Jan 23; 9(1). PMID: 31963582    Free PMC article.
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation.
Jessica N Spradlin, Xirui Hu, +15 authors, Daniel K Nomura.
Nat Chem Biol, 2019 Jun 19; 15(7). PMID: 31209351    Free PMC article.
Highly Cited.
Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer.
Jing Tang, Prson Gautam, +13 authors, Tero Aittokallio.
NPJ Syst Biol Appl, 2019 Jul 18; 5. PMID: 31312514    Free PMC article.
Androgens Induce Invasiveness of Triple Negative Breast Cancer Cells Through AR/Src/PI3-K Complex Assembly.
Pia Giovannelli, Marzia Di Donato, +2 authors, Antimo Migliaccio.
Sci Rep, 2019 Mar 16; 9(1). PMID: 30872694    Free PMC article.
RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis.
Jin Yeop Kim, Dong Min Lee, +4 authors, Kyeong Sook Choi.
Sci Rep, 2019 Mar 22; 9(1). PMID: 30894572    Free PMC article.
Mapping Bromodomains in breast cancer and association with clinical outcome.
Javier Pérez-Pena, Raquel Páez, +5 authors, Alberto Ocana.
Sci Rep, 2019 Apr 07; 9(1). PMID: 30952871    Free PMC article.
The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.
Ameer L Elaimy, John J Amante, +5 authors, Arthur M Mercurio.
Proc Natl Acad Sci U S A, 2019 Jun 27; 116(28). PMID: 31235595    Free PMC article.
Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles.
Anbarasu Kannan, Julie V Philley, +6 authors, Santanu Dasgupta.
Sci Rep, 2019 Aug 14; 9(1). PMID: 31406142    Free PMC article.
Integrative 3' Untranslated Region-Based Model to Identify Patients with Low Risk of Axillary Lymph Node Metastasis in Operable Triple-Negative Breast Cancer.
Lei Wang, Xin Hu, Peng Wang, Zhi-Ming Shao.
Oncologist, 2018 Aug 08; 24(1). PMID: 30082491    Free PMC article.
A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics.
Jelmar Quist, Hasan Mirza, +5 authors, Anita Grigoriadis.
Molecular cancer therapeutics, 2018 Oct 12; 18(1). PMID: 30305342    Free PMC article.
Chemotaxis Model for Breast Cancer Cells Based on Signal/Noise Ratio.
Seongjin Lim, Hyeono Nam, Jessie S Jeon.
Biophys J, 2018 Oct 28; 115(10). PMID: 30366624    Free PMC article.
Triptolide Decreases Cell Proliferation and Induces Cell Death in Triple Negative MDA-MB-231 Breast Cancer Cells.
Elizabeth Varghese, Samson Mathews Samuel, +3 authors, Dietrich Büsselberg.
Biomolecules, 2018 Dec 20; 8(4). PMID: 30563138    Free PMC article.
LRP8 is overexpressed in estrogen-negative breast cancers and a potential target for these tumors.
Virginie Maire, Faisal Mahmood, +7 authors, Thierry Dubois.
Cancer Med, 2018 Dec 24; 8(1). PMID: 30575334    Free PMC article.
SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors.
Tamer A Ahmed, Christos Adamopoulos, +4 authors, Poulikos I Poulikakos.
Cell Rep, 2019 Jan 04; 26(1). PMID: 30605687    Free PMC article.
High Glucose Represses the Anti-Proliferative and Pro-Apoptotic Effect of Metformin in Triple Negative Breast Cancer Cells.
Sharon Varghese, Samson Mathews Samuel, +2 authors, Dietrich Büsselberg.
Biomolecules, 2019 Jan 11; 9(1). PMID: 30626087    Free PMC article.
TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance.
Veenu Tripathi, Jee-Hye Shin, Christina H Stuelten, Ying E Zhang.
Oncogene, 2019 Jan 11; 38(17). PMID: 30626936    Free PMC article.
Germline TP53 and MSH6 mutations implicated in sporadic triple-negative breast cancer (TNBC): a preliminary study.
Dandan Yi, Lei Xu, +12 authors, Jianfeng Sang.
Hum Genomics, 2019 Jan 12; 13(1). PMID: 30630526    Free PMC article.
Obesity-induced MBD2_v2 expression promotes tumor-initiating triple-negative breast cancer stem cells.
Emily A Teslow, Cristina Mitrea, +5 authors, Aliccia Bollig-Fischer.
Mol Oncol, 2019 Jan 13; 13(4). PMID: 30636104    Free PMC article.
Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment.
Ana C Garrido-Castro, Nancy U Lin, Kornelia Polyak.
Cancer Discov, 2019 Jan 27; 9(2). PMID: 30679171    Free PMC article.
Highly Cited. Review.
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies.
Yahya Ashraf, Hanane Mansouri, +34 authors, Emmanuelle Liaudet-Coopman.
J Immunother Cancer, 2019 Feb 06; 7(1). PMID: 30717773    Free PMC article.
Combined Targeted Therapies for First-line Treatment of Metastatic Triple Negative Breast Cancer-A Phase II Trial of Weekly Nab-Paclitaxel and Bevacizumab Followed by Maintenance Targeted Therapy With Bevacizumab and Erlotinib.
Lynn Symonds, Hannah Linden, +14 authors, Jennifer Specht.
Clin Breast Cancer, 2019 Feb 10; 19(2). PMID: 30737173    Free PMC article.
Tailored NEOadjuvant epirubicin, cyclophosphamide and Nanoparticle Albumin-Bound paclitaxel for breast cancer: The phase II NEONAB trial-Clinical outcomes and molecular determinants of response.
Caitlin Murphy, Andrea Muscat, +10 authors, Mustafa Khasraw.
PLoS One, 2019 Feb 15; 14(2). PMID: 30763338    Free PMC article.
MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer.
Yoshimi Endo Greer, Samuel F Gilbert, +5 authors, Stanley Lipkowitz.
Breast Cancer Res, 2019 Feb 20; 21(1). PMID: 30777098    Free PMC article.
Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer.
Jiangsheng Xu, Yunhua Liu, +10 authors, Xiaoming He.
Nat Nanotechnol, 2019 Feb 26; 14(4). PMID: 30804480    Free PMC article.
MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells.
Masaaki Yamamoto, Caining Jin, +10 authors, Donald Kufe.
Cancer Res, 2019 Mar 03; 79(8). PMID: 30824588    Free PMC article.
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
Jiyoung Lee, Ali E Yesilkanal, +16 authors, Marsha Rich Rosner.
Nature, 2019 Mar 08; 568(7751). PMID: 30842661    Free PMC article.
Highly Cited.
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.
Zitong Zhao, Lin Li, +9 authors, Yongmei Song.
Theranostics, 2019 Mar 15; 9(5). PMID: 30867840    Free PMC article.
GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and β-catenin activity.
Gordana Maric, Matthew G Annis, +5 authors, Peter M Siegel.
Oncogene, 2019 Mar 28; 38(26). PMID: 30914799
Protein arginine methyltransferase 5: A novel therapeutic target for triple-negative breast cancers.
Mathilde Vinet, Samyuktha Suresh, +14 authors, Thierry Dubois.
Cancer Med, 2019 Apr 09; 8(5). PMID: 30957988    Free PMC article.
Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells.
Sianadh Dunn, Olivia Lombardi, Radoslaw Lukoszek, Victoria H Cowling.
Open Biol, 2019 Apr 18; 9(4). PMID: 30991934    Free PMC article.
Integrin α9 depletion promotes β-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.
Zhishan Wang, Yunfei Li, +5 authors, Chengfeng Yang.
Int J Cancer, 2019 Apr 23; 145(10). PMID: 31008533    Free PMC article.
Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics.
Natalia A Riobo-Del Galdo, Ángela Lara Montero, Eva V Wertheimer.
Cells, 2019 Apr 28; 8(4). PMID: 31027259    Free PMC article.
Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications.
Pascal Jézéquel, Olivier Kerdraon, +11 authors, Mario Campone.
Breast Cancer Res, 2019 May 19; 21(1). PMID: 31101122    Free PMC article.
Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer.
Alina Malyutina, Muntasir Mamun Majumder, +3 authors, Jing Tang.
PLoS Comput Biol, 2019 May 21; 15(5). PMID: 31107860    Free PMC article.
Loss of PICH promotes chromosome instability and cell death in triple-negative breast cancer.
Yan Huang, Wanjin Li, +17 authors, Tao Zhou.
Cell Death Dis, 2019 Jun 05; 10(6). PMID: 31160555    Free PMC article.
Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers.
Bradley A Hancock, Yu-Hsiang Chen, +14 authors, Milan Radovich.
Breast Cancer Res, 2019 Aug 07; 21(1). PMID: 31383035    Free PMC article.
Investigating circulating tumor cells and distant metastases in patient-derived orthotopic xenograft models of triple-negative breast cancer.
Vishnu C Ramani, Clementine A Lemaire, +10 authors, Stefanie S Jeffrey.
Breast Cancer Res, 2019 Aug 30; 21(1). PMID: 31462307    Free PMC article.
Rationally Designed Ruthenium Complexes for Breast Cancer Therapy.
Golara Golbaghi, Annie Castonguay.
Molecules, 2020 Jan 16; 25(2). PMID: 31936496    Free PMC article.
Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice.
Nigel Bush, Andrew Healey, +9 authors, Jeffrey Bamber.
Front Pharmacol, 2020 Mar 11; 11. PMID: 32153400    Free PMC article.
Arrestin Domain Containing 3 Reverses Epithelial to Mesenchymal Transition and Chemo-Resistance of TNBC Cells by Up-Regulating Expression of miR-200b.
Young Hwa Soung, Heesung Chung, +2 authors, Jun Chung.
Cells, 2019 Jul 13; 8(7). PMID: 31295851    Free PMC article.
An Overview of Vasculogenic Mimicry in Breast Cancer.
Marco A Andonegui-Elguera, Yair Alfaro-Mora, +3 authors, José Díaz-Chávez.
Front Oncol, 2020 Mar 17; 10. PMID: 32175277    Free PMC article.
Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells.
Manuel Abreu, Pablo Cabezas-Sainz, +18 authors, Laura Muinelo-Romay.
J Clin Med, 2020 Feb 06; 9(2). PMID: 32012729    Free PMC article.
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis.
Qiang Chen, Josh Haipeng Lei, +9 authors, Chu-Xia Deng.
Adv Sci (Weinh), 2020 Mar 21; 7(6). PMID: 32195105    Free PMC article.
Development and characterization of mammary intraductal (MIND) spontaneous metastasis models for triple-negative breast cancer in syngeneic mice.
Xu-Liang Luo, Lan Lin, +5 authors, Yuan-Qiao He.
Sci Rep, 2020 Mar 15; 10(1). PMID: 32170125    Free PMC article.
A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells.
Ran Ran, Hannah Harrison, +9 authors, Paul Shore.
Oncogene, 2020 Feb 02; 39(12). PMID: 32005976    Free PMC article.
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.
Maren Pein, Jacob Insua-Rodríguez, +11 authors, Thordur Oskarsson.
Nat Commun, 2020 Mar 22; 11(1). PMID: 32198421    Free PMC article.
LncRNA PAPAS may promote triple-negative breast cancer by downregulating miR-34a.
Yan Kong, Cuizhi Geng, Qian Dong.
J Int Med Res, 2019 Jun 30; 47(8). PMID: 31248310    Free PMC article.
A bioinformatics approach to identify novel long, non-coding RNAs in breast cancer cell lines from an existing RNA-sequencing dataset.
Oza Zaheed, Julia Samson, Kellie Dean.
Noncoding RNA Res, 2020 Mar 25; 5(2). PMID: 32206740    Free PMC article.
Nanoparticle-Mediated Co-Delivery of Notch-1 Antibodies and ABT-737 as a Potent Treatment Strategy for Triple-Negative Breast Cancer.
Danielle M Valcourt, Megan N Dang, Mackenzie A Scully, Emily S Day.
ACS Nano, 2020 Feb 23; 14(3). PMID: 32083466    Free PMC article.
Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187.
Zhonghao Wang, Qiong Kong, +20 authors, Ting Zhuang.
Oncogenesis, 2020 Mar 22; 9(3). PMID: 32198343    Free PMC article.
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Wei Xu, Minghua Huang, +7 authors, Kun Mu.
Int J Biol Sci, 2020 Mar 27; 16(8). PMID: 32210727    Free PMC article.
Pin1 plays a key role in the response to treatment and clinical outcome in triple negative breast cancer.
Catherine Knowlson, Paula Haddock, +3 authors, Niamh E Buckley.
Ther Adv Med Oncol, 2020 Mar 28; 12. PMID: 32215056    Free PMC article.
A common Chk1-dependent phenotype of DNA double-strand break suppression in two distinct radioresistant cancer types.
Patrick H Dinkelborg, Meng Wang, +7 authors, Henning Willers.
Breast Cancer Res Treat, 2019 Jan 05; 174(3). PMID: 30607635    Free PMC article.
F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function.
Debasish Paul, Sehbanul Islam, +7 authors, Manas Kumar Santra.
J Pathol, 2019 Feb 05; 248(3). PMID: 30714168    Free PMC article.
Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches.
Jess D Hebert, Samuel A Myers, +4 authors, Richard O Hynes.
Cancer Res, 2020 Feb 06; 80(7). PMID: 32019869    Free PMC article.
Sanguinarine disrupts the colocalization and interaction of HIF-1α with tyrosine and serine phosphorylated-STAT3 in breast cancer.
Qi Su, Jingjing Wang, +7 authors, Yanmin Zhang.
J Cell Mol Med, 2020 Feb 18; 24(6). PMID: 32065498    Free PMC article.
Heterogeneity at the invasion front of triple negative breast cancer cells.
Koh Meng Aw Yong, Peter J Ulintz, +5 authors, Sofia D Merajver.
Sci Rep, 2020 Apr 03; 10(1). PMID: 32238832    Free PMC article.
Up-regulated lncRNA GAS5 promotes chemosensitivity and apoptosis of triple-negative breast cancer cells.
Juntao Li, Lin Li, +3 authors, Sujuan Dai.
Cell cycle (Georgetown, Tex.), 2019 Jul 10; 18(16). PMID: 31282278    Free PMC article.
Cellular, transcriptomic and isoform heterogeneity of breast cancer cell line revealed by full-length single-cell RNA sequencing.
Shaocheng Wu, Hongjiu Zhang, +6 authors, Yuanfang Guan.
Comput Struct Biotechnol J, 2020 Apr 08; 18. PMID: 32257051    Free PMC article.
Evaluation of 6-mercaptopurine in a cell culture model of adaptable triple-negative breast cancer with metastatic potential.
Balraj Singh, Vanessa N Sarli, +2 authors, Anthony Lucci.
Oncotarget, 2019 Jun 21; 10(38). PMID: 31217902    Free PMC article.
MicroRNA-590-3p inhibits invasion and metastasis in triple-negative breast cancer by targeting Slug.
Meisi Yan, Leiguang Ye, +4 authors, Tong Liu.
Am J Cancer Res, 2020 Apr 09; 10(3). PMID: 32266103    Free PMC article.
Model-Based Integration Analysis Revealed Presence of Novel Prognostic miRNA Targets and Important Cancer Driver Genes in Triple-Negative Breast Cancers.
Masood Zaka, Chris W Sutton, Yonghong Peng, Savas Konur.
Cancers (Basel), 2020 Mar 19; 12(3). PMID: 32182819    Free PMC article.
The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer.
Lei Ding, Jiaqi Cao, +6 authors, Qinghua Cui.
Int J Mol Sci, 2020 Mar 19; 21(6). PMID: 32183020    Free PMC article.
IR820-loaded PLGA nanoparticles for photothermal therapy of triple-negative breast cancer.
Danielle M Valcourt, Megan N Dang, Emily S Day.
J Biomed Mater Res A, 2019 Mar 29; 107(8). PMID: 30920169    Free PMC article.
Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer.
Yulia Liubomirski, Shalom Lerrer, +5 authors, Adit Ben-Baruch.
Front Immunol, 2019 Apr 30; 10. PMID: 31031757    Free PMC article.
Highly Cited.
A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling.
Yujie Huang, Jiansong Fang, +9 authors, Feixiong Cheng.
Cell Chem Biol, 2019 Jun 11; 26(8). PMID: 31178408    Free PMC article.
Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer.
Yulia Liubomirski, Shalom Lerrer, +7 authors, Adit Ben-Baruch.
Front Immunol, 2019 May 21; 10. PMID: 31105691    Free PMC article.
GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer.
Geraldine Vidhya Vijay, Na Zhao, +18 authors, Sendurai A Mani.
Breast Cancer Res, 2019 Mar 09; 21(1). PMID: 30845991    Free PMC article.
A plasma protein derived TGFβ signature is a prognostic indicator in triple negative breast cancer.
Hiroyuki Katayama, Peiling Tsou, +5 authors, Samir Hanash.
NPJ Precis Oncol, 2019 Apr 10; 3. PMID: 30963111    Free PMC article.
17‑AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA‑MB‑231 breast cancer cells.
Yu Zuo, Heng Xu, +6 authors, Hao Zhang.
Oncol Rep, 2020 Apr 03; 43(6). PMID: 32236631    Free PMC article.
Isoliquiritigenin Derivative Regulates miR-374a/BAX Axis to Suppress Triple-Negative Breast Cancer Tumorigenesis and Development.
Fu Peng, Liang Xiong, +3 authors, Cheng Peng.
Front Pharmacol, 2020 Apr 17; 11. PMID: 32296334    Free PMC article.
Risk stratification of ER-positive breast cancer patients: A multi-institutional validation and outcome study of the Rochester Modified Magee algorithm (RoMMa) and prediction of an Oncotype DX® recurrence score <26.
Bradley M Turner, Mary Ann Gimenez-Sanders, +6 authors, David G Hicks.
Cancer Med, 2019 Jun 15; 8(9). PMID: 31199586    Free PMC article.
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Weilin Wang, Runze Zhang, +5 authors, Chengqin Wang.
Cancer Sci, 2020 Feb 06; 111(4). PMID: 32011034    Free PMC article.
Creatine based polymer for codelivery of bioengineered MicroRNA and chemodrugs against breast cancer lung metastasis.
Jieni Xu, Jingjing Sun, +9 authors, Song Li.
Biomaterials, 2019 May 06; 210. PMID: 31054369    Free PMC article.
EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis.
Guillermo Peluffo, Ashim Subedee, +17 authors, Kornelia Polyak.
Cancer Res, 2019 Jun 27; 79(16). PMID: 31239270    Free PMC article.
Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling.
Jing Zhang, Yu Yang, +9 authors, Liming Sun.
Cell Death Differ, 2019 Oct 28; 27(5). PMID: 31645676    Free PMC article.
Anti-cancer Activity of Centipeda minima Extract in Triple Negative Breast Cancer via Inhibition of AKT, NF-κB, and STAT3 Signaling Pathways.
Magnolia Muk-Lan Lee, Brandon Dow Chan, +7 authors, William Chi-Shing Tai.
Front Oncol, 2020 Apr 25; 10. PMID: 32328465    Free PMC article.
Breast cancer models: Engineering the tumor microenvironment.
Gokhan Bahcecioglu, Gozde Basara, +2 authors, Pinar Zorlutuna.
Acta Biomater, 2020 Feb 12; 106. PMID: 32045679    Free PMC article.
Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype.
Corena V Grant, Chase M Carver, +5 authors, Susan L Mooberry.
Breast Cancer Res Treat, 2019 Jun 24; 177(2). PMID: 31230251    Free PMC article.
Cellular plasticity and metastasis in breast cancer: a pre- and post-malignant problem.
Jacob M Smigiel, Sarah E Taylor, +3 authors, Mark W Jackson.
J Cancer Metastasis Treat, 2019 Jan 01; 5. PMID: 32355893    Free PMC article.
Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression.
Tzu-Ting Huang, Ling-Ming Tseng, +12 authors, Chun-Yu Liu.
EBioMedicine, 2020 Apr 09; 54. PMID: 32268268    Free PMC article.
Recent advances in understanding breast cancer and emerging therapies with a focus on luminal and triple-negative breast cancer.
Georges El Hachem, Andrea Gombos, Ahmad Awada.
F1000Res, 2019 May 10; 8. PMID: 31069063    Free PMC article.
EGFR-targeted CAR-T cells are potent and specific in suppressing triple-negative breast cancer both in vitro and in vivo.
Lin Xia, Zao-Zao Zheng, +5 authors, Wen Liu.
Clin Transl Immunology, 2020 May 07; 9(5). PMID: 32373345    Free PMC article.
Expression of Tumour-Associated MUC1 Is a Poor Prognostic Marker in Breast Cancer in Kumasi, Ghana.
E Atta Manu, K Bedu-Addo, +3 authors, B M Duduyemi.
J Oncol, 2020 May 08; 2020. PMID: 32377198    Free PMC article.
Ultrasonographic appearance of triple-negative invasive breast carcinoma is associated with novel molecular subtypes based on transcriptomic analysis.
Jia-Wei Li, Na Li, +4 authors, Zhi-Ming Shao.
Ann Transl Med, 2020 May 13; 8(7). PMID: 32395479    Free PMC article.
Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos.
Golara Golbaghi, Irène Pitard, +6 authors, Annie Castonguay.
Eur J Med Chem, 2020 Jan 17; 188. PMID: 31945643    Free PMC article.
Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer.
Leticia Serrano-Oviedo, Miriam Nuncia-Cantarero, +7 authors, Eva María Galán-Moya.
Cell Oncol (Dordr), 2020 Mar 14; 43(3). PMID: 32166583    Free PMC article.
Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression.
Jichao He, Ronan P McLaughlin, +7 authors, Bob van de Water.
Oncogene, 2020 Apr 03; 39(20). PMID: 32235890    Free PMC article.
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy.
Renee C Geck, Jackson R Foley, +3 authors, Alex Toker.
J Biol Chem, 2020 Mar 07; 295(19). PMID: 32139506    Free PMC article.
Early Triple Negative Breast Cancer: Conventional Treatment and Emerging Therapeutic Landscapes.
Anna Diana, Francesca Carlino, +5 authors, Michele Orditura.
Cancers (Basel), 2020 Apr 03; 12(4). PMID: 32235297    Free PMC article.
EHD2 is a Predictive Biomarker of Chemotherapy Efficacy in Triple Negative Breast Carcinoma.
Wei-Wei Shen, Ivan Bièche, +4 authors, Christophe Lamaze.
Sci Rep, 2020 May 16; 10(1). PMID: 32409676    Free PMC article.
Metformin and Its Benefits for Various Diseases.
Ziquan Lv, Yajie Guo.
Front Endocrinol (Lausanne), 2020 May 20; 11. PMID: 32425881    Free PMC article.
Cost-effectiveness of adding atezolizumab to first-line chemotherapy in patients with advanced triple-negative breast cancer.
Bin Wu, Fei Ma.
Ther Adv Med Oncol, 2020 May 20; 12. PMID: 32426048    Free PMC article.
Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors.
Praveen Vikas, Nicholas Borcherding, Adithya Chennamadhavuni, Rohan Garje.
Front Oncol, 2020 May 28; 10. PMID: 32457830    Free PMC article.
Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.
Mariela A Moreno Ayala, María Florencia Gottardo, +9 authors, Marianela Candolfi.
Sci Rep, 2020 May 24; 10(1). PMID: 32444831    Free PMC article.
PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer.
Constantia Pantelidou, Olmo Sonzogni, +14 authors, Geoffrey I Shapiro.
Cancer Discov, 2019 Apr 25; 9(6). PMID: 31015319    Free PMC article.
Highly Cited.
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression.
Teresa Gagliano, Kalpit Shah, +24 authors, Georgios Giamas.
J Clin Invest, 2020 Mar 04; 130(6). PMID: 32125284    Free PMC article.
EZH2 inhibitors-mediated epigenetic reactivation of FOSB inhibits triple-negative breast cancer progress.
Ruishan Zhang, Xiang Li, +3 authors, Hong Xu.
Cancer Cell Int, 2020 Jun 02; 20. PMID: 32477007    Free PMC article.
Loss of myeloid-specific lamin A/C drives lung metastasis through Gfi-1 and C/EBPε-mediated granulocytic differentiation.
Hiroki Ishii, Woo-Yong Park, +6 authors, Li Yang.
Mol Carcinog, 2020 Jan 09; 59(7). PMID: 31912614    Free PMC article.
Actionable gene alterations in an Asian population with triple-negative breast cancer.
Masayuki Nagahashi, YiWei Ling, +20 authors, Toshifumi Wakai.
JCO Precis Oncol, 2018 Jan 01; 2. PMID: 32529167    Free PMC article.
Application of a Biphasic Mathematical Model of Cancer Cell Drug Response for Formulating Potent and Synergistic Targeted Drug Combinations to Triple Negative Breast Cancer Cells.
Jinyan Shen, Li Li, +2 authors, Gongqin Sun.
Cancers (Basel), 2020 May 01; 12(5). PMID: 32349331    Free PMC article.
Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer.
Gagan Gupta, Caroline Dasom Lee, +10 authors, Amy H Tang.
Ann Breast Cancer Ther, 2020 Jun 17; 4(1). PMID: 32542231    Free PMC article.
Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.
Chun Wang, Zhaomei Mu, +22 authors, Hushan Yang.
Breast Cancer Res Treat, 2020 May 06; 181(3). PMID: 32367460    Free PMC article.
Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein.
Xinxiao Li, Yunfeng Liu, +7 authors, Danrong Li.
Front Pharmacol, 2020 Jun 18; 11. PMID: 32547389    Free PMC article.
Glucocorticoid Receptor Expression Predicts Good Outcome in response to Taxane-Free, Anthracycline-Based Therapy in Triple Negative Breast Cancer.
Ahmed Elkashif, Victoria Bingham, +5 authors, Niamh E Buckley.
J Oncol, 2020 Jun 23; 2020. PMID: 32565802    Free PMC article.
ALICE: a randomized placebo-controlled phase II study evaluating atezolizumab combined with immunogenic chemotherapy in patients with metastatic triple-negative breast cancer.
J A Kyte, A Røssevold, R S Falk, B Naume.
J Transl Med, 2020 Jun 25; 18(1). PMID: 32576225    Free PMC article.
Maslinic Acid Enhances Docetaxel Response in Human Docetaxel-Resistant Triple Negative Breast Carcinoma MDA-MB-231 Cells via Regulating MELK-FoxM1-ABCB1 Signaling Cascade.
Ke Wang, Xue Zhu, Yongxiang Yin.
Front Pharmacol, 2020 Jun 26; 11. PMID: 32581798    Free PMC article.
Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells.
Sophia J Lang, Michael Schmiech, +6 authors, Thomas Simmet.
Int J Mol Sci, 2020 Jun 12; 21(11). PMID: 32521698    Free PMC article.
Novel Insights Into Triple-Negative Breast Cancer Prognosis by Comprehensive Characterization of Aberrant Alternative Splicing.
Shasha Gong, Zhijian Song, +6 authors, Yong Liang.
Front Genet, 2020 Jul 01; 11. PMID: 32595697    Free PMC article.
Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients.
Kerry-Ann McDonald, Tsutomu Kawaguchi, +8 authors, Kazuaki Takabe.
Ann Surg Oncol, 2019 Apr 10; 26(7). PMID: 30963401    Free PMC article.
Highly Cited.
A Polyphenol-Rich Extract From Muscadine Grapes Inhibits Triple-Negative Breast Tumor Growth.
Marianne Collard, Patricia E Gallagher, E Ann Tallant.
Integr Cancer Ther, 2020 Jun 25; 19. PMID: 32578460    Free PMC article.
Dual Regulation of miR-34a and Notch Signaling in Triple-Negative Breast Cancer by Antibody/miRNA Nanocarriers.
Danielle M Valcourt, Emily S Day.
Mol Ther Nucleic Acids, 2020 Jul 06; 21. PMID: 32622330    Free PMC article.
A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer.
Amedeo Amedei, Fatemeh Asadzadeh, +22 authors, Cristina Nativi.
iScience, 2020 Jul 08; 23(6). PMID: 32629615    Free PMC article.
Comparison of unsupervised machine-learning methods to identify metabolomic signatures in patients with localized breast cancer.
Jocelyn Gal, Caroline Bailleux, +11 authors, Emmanuel Chamorey.
Comput Struct Biotechnol J, 2020 Jul 09; 18. PMID: 32637048    Free PMC article.
Sequential deconstruction of composite drug transport in metastatic breast cancer.
Shreya Goel, Guodong Zhang, +8 authors, Mauro Ferrari.
Sci Adv, 2020 Jul 09; 6(26). PMID: 32637609    Free PMC article.
RNF181 modulates Hippo signaling and triple negative breast cancer progression.
Rui Zhou, Yinlu Ding, +2 authors, Ting Zhuang.
Cancer Cell Int, 2020 Jul 14; 20. PMID: 32655323    Free PMC article.
Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer.
Assunta Sellitto, Ylenia D'Agostino, +10 authors, Francesca Rizzo.
Cancers (Basel), 2020 Jun 11; 12(6). PMID: 32516978    Free PMC article.
Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.
Sheelagh Frame, Chiara Saladino, +7 authors, Daniella Zheleva.
PLoS One, 2020 Jul 10; 15(7). PMID: 32645016    Free PMC article.
DNA methylation of the long intergenic noncoding RNA 299 gene in triple-negative breast cancer: results from a prospective study.
Mehdi Manoochehri, Michael Jones, +5 authors, Ute Hamann.
Sci Rep, 2020 Jul 18; 10(1). PMID: 32678138    Free PMC article.
Metabolic and OXPHOS Activities Quantified by Temporal ex vivo Analysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers.
Andre Koit, Natalja Timohhina, +8 authors, Tuuli Kaambre.
Front Oncol, 2020 Jul 23; 10. PMID: 32695682    Free PMC article.
Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study.
Shristi Bhattarai, Sergey Klimov, +27 authors, Ritu Aneja.
Cancers (Basel), 2019 Jul 20; 11(7). PMID: 31319547    Free PMC article.
Sonography with vertical orientation feature predicts worse disease outcome in triple negative breast cancer.
Haoyu Wang, Weiwei Zhan, +3 authors, Kunwei Shen.
Breast, 2019 Nov 05; 49. PMID: 31677531    Free PMC article.
RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer.
Tian-Hao Weng, Min-Ya Yao, +8 authors, Hang-Ping Yao.
Cancer Res Treat, 2020 Apr 24; 52(3). PMID: 32324988    Free PMC article.
Proliferation-associated long noncoding RNA, TMPO-AS1, is a potential therapeutic target for triple-negative breast cancer.
Yuichi Mitobe, Kazuhiro Ikeda, +8 authors, Satoshi Inoue.
Cancer Sci, 2020 May 22; 111(7). PMID: 32437068    Free PMC article.
Diagnostic value of Doppler ultrasound parameters combined with MMP-11 in early breast cancer and benign breast diseases.
Hui Ren, Zhipeng Shen, +2 authors, Yunhua Zhang.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724341    Free PMC article.
RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.
Seong-Jin Kim, Jin-Sung Ju, +13 authors, Yun-Yong Park.
Theranostics, 2020 Jul 30; 10(18). PMID: 32724453    Free PMC article.
Repurposing of drugs for triple negative breast cancer: an overview.
Andrea Spini, Sandra Donnini, +2 authors, Marina Ziche.
Ecancermedicalscience, 2020 Jul 31; 14. PMID: 32728387    Free PMC article.
Combination of Detoxified Pneumolysin Derivative ΔA146Ply and Berbamine as a Treatment Approach for Breast Cancer.
Hong Zhang, Tao Zhu, +8 authors, Xuemei Zhang.
Mol Ther Oncolytics, 2020 Jul 31; 18. PMID: 32728613    Free PMC article.
Identification of a prognosis‑associated signature associated with energy metabolism in triple‑negative breast cancer.
Chao Li, Xujun Li, +4 authors, Qidong Ge.
Oncol Rep, 2020 Jun 26; 44(3). PMID: 32582991    Free PMC article.
Long Non-Coding RNA MNX1-AS1 Promotes Progression of Triple Negative Breast Cancer by Enhancing Phosphorylation of Stat3.
Junhua Li, Qingjian Li, +4 authors, Yujuan Li.
Front Oncol, 2020 Aug 06; 10. PMID: 32754442    Free PMC article.
The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer.
Rhona Millar, Anna Kilbey, +7 authors, Seth B Coffelt.
Mol Oncol, 2020 Jun 03; 14(8). PMID: 32484599    Free PMC article.
OSW-1 inhibits tumor growth and metastasis by NFATc2 on triple-negative breast cancer.
Xiaorong Ding, Yumei Li, Jun Li, Yongmei Yin.
Cancer Med, 2020 Jun 10; 9(15). PMID: 32515123    Free PMC article.
IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils.
Timothy N Trotter, Casey W Shuptrine, +8 authors, Zachary C Hartman.
Cancer Res, 2020 May 06; 80(15). PMID: 32366475    Free PMC article.
Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer.
Davide Zecchin, Christopher Moore, +4 authors, Julian Downward.
EMBO Mol Med, 2020 Jul 17; 12(8). PMID: 32672423    Free PMC article.
Identification of Important Modules and Biomarkers in Breast Cancer Based on WGCNA.
Zelin Tian, Weixiang He, +4 authors, Gaosong Wu.
Onco Targets Ther, 2020 Aug 09; 13. PMID: 32764968    Free PMC article.
Prognostic and clinicopathological values of tissue expression of MFAP5 and ITM2A in triple-negative breast cancer: an immunohistochemical study.
Abdulwahab A Abuderman, Ola A Harb, Loay M Gertallah.
Contemp Oncol (Pozn), 2020 Aug 11; 24(2). PMID: 32774133    Free PMC article.
miR-622 is a novel potential biomarker of breast carcinoma and impairs motility of breast cancer cells through targeting NUAK1 kinase.
Francesca Maria Orlandella, Raffaela Mariarosaria Mariniello, +11 authors, Giuliana Salvatore.
Br J Cancer, 2020 May 19; 123(3). PMID: 32418991    Free PMC article.
Metabolic Signatures of Tumor Responses to Doxorubicin Elucidated by Metabolic Profiling in Ovo.
Iman W Achkar, Sara Kader, +9 authors, Anna Halama.
Metabolites, 2020 Jul 02; 10(7). PMID: 32605263    Free PMC article.
The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs).
Rosamaria Lappano, Marianna Talia, +8 authors, Marcello Maggiolini.
J Exp Clin Cancer Res, 2020 Aug 12; 39(1). PMID: 32778144    Free PMC article.
Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation.
Buthina A Al-Oudat, Hariteja Ramapuram, +7 authors, Amit K Tiwari.
Molecules, 2020 Jul 09; 25(13). PMID: 32635530    Free PMC article.
ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers.
Wei Wang, Mingqi Li, +8 authors, Zhao-Hui Wu.
Nat Commun, 2020 Aug 10; 11(1). PMID: 32770022    Free PMC article.
Hitting the brakes on autophagy for overcoming acquired resistance in triple negative breast cancer.
Chiara Bellio, Josep Villanueva.
Ann Transl Med, 2020 Aug 15; 8(14). PMID: 32793692    Free PMC article.
WNT signaling pathway regulator-FRAT2 affects oncogenesis and prognosis of basal-like breast cancer.
Yao Zhou, Can Li, +5 authors, Taiyuan Li.
J Thorac Dis, 2020 Aug 18; 12(7). PMID: 32802426    Free PMC article.
Advances in Anti-Cancer Immunotherapy: Car-T Cell, Checkpoint Inhibitors, Dendritic Cell Vaccines, and Oncolytic Viruses, and Emerging Cellular and Molecular Targets.
Emilie Alard, Aura-Bianca Butnariu, +5 authors, Md Zahidul Islam Pranjol.
Cancers (Basel), 2020 Jul 11; 12(7). PMID: 32645977    Free PMC article.
Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines.
Seyed Ali Hashemi, Seyedeh Zahra Bathaie, Mohammad Ali Mohagheghi.
Avicenna J Phytomed, 2020 Aug 28; 10(4). PMID: 32850295    Free PMC article.
MicroRNA-27b-3p Promotes Tumor Progression and Metastasis by Inhibiting Peroxisome Proliferator-Activated Receptor Gamma in Triple-Negative Breast Cancer.
Song-Jie Shen, Yu Song, +4 authors, Qiang Sun.
Front Oncol, 2020 Aug 28; 10. PMID: 32850439    Free PMC article.
Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer.
S M Jusu, J D Obayemi, +4 authors, W O Soboyejo.
Sci Rep, 2020 Aug 28; 10(1). PMID: 32843673    Free PMC article.
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.
Qin Wu, Wail Ba-Alawi, +26 authors, Cheryl H Arrowsmith.
Nat Commun, 2020 Aug 23; 11(1). PMID: 32826891    Free PMC article.
Identification and validation of stemness-related lncRNA prognostic signature for breast cancer.
Xiaoying Li, Yang Li, Xinmiao Yu, Feng Jin.
J Transl Med, 2020 Sep 02; 18(1). PMID: 32867770    Free PMC article.
The Function of BARD1 in Centrosome Regulation in Cooperation with BRCA1/OLA1/RACK1.
Kei Otsuka, Yuki Yoshino, Huicheng Qi, Natsuko Chiba.
Genes (Basel), 2020 Jul 30; 11(8). PMID: 32722046    Free PMC article.
Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids.
Ângela R Guerra, Ana F Paulino, +3 authors, Iola F Duarte.
Biomolecules, 2020 Aug 14; 10(8). PMID: 32784479    Free PMC article.
Therapeutic Potential of Chemically Modified miR-489 in Triple-Negative Breast Cancers.
Young Hwa Soung, Heesung Chung, +5 authors, Jun Chung.
Cancers (Basel), 2020 Aug 14; 12(8). PMID: 32784600    Free PMC article.
Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach.
Zeinab Nouri, Sajad Fakhri, +3 authors, Anupam Bishayee.
Cancers (Basel), 2020 Aug 23; 12(8). PMID: 32823876    Free PMC article.
Epithelial-Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance.
Alex J Gooding, William P Schiemann.
Mol Cancer Res, 2020 Jun 07; 18(9). PMID: 32503922    Free PMC article.
LncRNA DLG1-AS1 Promotes Cancer Cell Proliferation in Triple Negative Breast Cancer by Downregulating miR-203.
Shuyan Li.
J Breast Cancer, 2020 Sep 11; 23(4). PMID: 32908786    Free PMC article.
Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide.
Adam C Mirando, Akash Patil, +6 authors, Aleksander S Popel.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923118    Free PMC article.
Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers.
Lei Wang, Guan-Tian Lang, +7 authors, Zhi-Ming Shao.
Theranostics, 2020 Sep 16; 10(23). PMID: 32929364    Free PMC article.
Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer.
Simona Camorani, Margherita Passariello, +9 authors, Laura Cerchia.
J Exp Clin Cancer Res, 2020 Sep 08; 39(1). PMID: 32892748    Free PMC article.
Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab.
Jie Li, Maoguang Ma, +8 authors, Nu Zhang.
Mol Cancer, 2020 Sep 13; 19(1). PMID: 32917240    Free PMC article.
Prognostic values of EDNRB in triple-negative breast cancer.
Shaoqing Liu, Jingyang Zhang, +2 authors, Zhenzhen Liu.
Oncol Lett, 2020 Sep 17; 20(5). PMID: 32934717    Free PMC article.
CircUBE2D2 (hsa_circ_0005728) promotes cell proliferation, metastasis and chemoresistance in triple-negative breast cancer by regulating miR-512-3p/CDCA3 axis.
Dongwei Dou, Xiaoyang Ren, +5 authors, Song Zhao.
Cancer Cell Int, 2020 Sep 19; 20. PMID: 32944002    Free PMC article.
Liposomal formulation of HIF-1α inhibitor echinomycin eliminates established metastases of triple-negative breast cancer.
Christopher M Bailey, Yan Liu, +6 authors, Yin Wang.
Nanomedicine, 2020 Aug 02; 29. PMID: 32738299    Free PMC article.
Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation.
Eike-Benjamin Braune, Anita Seshire, Urban Lendahl.
Biomedicines, 2018 Nov 06; 6(4). PMID: 30388742    Free PMC article.
TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities.
Simona Camorani, Monica Fedele, Antonella Zannetti, Laura Cerchia.
Pharmaceuticals (Basel), 2018 Nov 16; 11(4). PMID: 30428522    Free PMC article.
Interplay between Epigenetics, Expression of Estrogen Receptor- α, HER2/ERBB2 and Sensitivity of Triple Negative Breast Cancer Cells to Hormonal Therapy.
Wafaa S Ramadan, Cijo George Vazhappilly, +5 authors, Raafat El-Awady.
Cancers (Basel), 2018 Dec 26; 11(1). PMID: 30583472    Free PMC article.
Cancer-Associated Fibroblasts Correlate with Tumor-Associated Macrophages Infiltration and Lymphatic Metastasis in Triple Negative Breast Cancer Patients.
Jing Zhou, Xiao-Hua Wang, +13 authors, Wei-Jie Zhang.
J Cancer, 2018 Dec 28; 9(24). PMID: 30588247    Free PMC article.
Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells.
Kayla A Lewis, Harrison R Jordan, Trygve O Tollefsbol.
Cancers (Basel), 2018 Dec 29; 11(1). PMID: 30591655    Free PMC article.
Quadruple Negative Breast Cancers (QNBC) Demonstrate Subtype Consistency among Primary and Recurrent or Metastatic Breast Cancer.
Anusha Angajala, Essynce Mothershed, +5 authors, Clayton Yates.
Transl Oncol, 2018 Dec 30; 12(3). PMID: 30594038    Free PMC article.
Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer.
Bo Chen, Hailin Tang, +4 authors, Ning Liao.
Cancer Manag Res, 2019 Jan 08; 11. PMID: 30613165    Free PMC article.
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines.
Guan-Jun Yang, Chung-Nga Ko, +2 authors, Dik-Lung Ma.
Cancers (Basel), 2019 Jan 18; 11(1). PMID: 30650517    Free PMC article.
Efficacy and tolerability of BP-C1 in metastatic breast cancer: a Phase II, randomized, double-blind, and placebo-controlled Thai multi-center study.
Kritiya Butthongkomvong, Nilubol Raunroadroong, +4 authors, Stig Larsen.
Breast Cancer (Dove Med Press), 2019 Jan 23; 11. PMID: 30666153    Free PMC article.
Therapeutic Potential of a Novel αvβ₃ Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type.
Billy Samuel Hill, Annachiara Sarnella, +7 authors, Antonella Zannetti.
Cancers (Basel), 2019 Jan 27; 11(2). PMID: 30682838    Free PMC article.
Systemic immune-inflammation index and ultrasonographic classification of breast imaging-reporting and data system predict outcomes of triple-negative breast cancer.
Ping Wang, Wensheng Yue, +4 authors, Zhizhong He.
Cancer Manag Res, 2019 Jan 31; 11. PMID: 30697073    Free PMC article.
Health Behaviors and Lifestyle Interventions in African American Breast Cancer Survivors: A Review.
Raheem J Paxton, William Garner, +2 authors, Kristen Allen-Watts.
Front Oncol, 2019 Feb 07; 9. PMID: 30723698    Free PMC article.
Analysis of Treg cell population in patients with breast cancer with respect to progesterone receptor status.
Konrad Dziobek, Marta Biedka, +3 authors, Magdalena Dutsch-Wicherek.
Contemp Oncol (Pozn), 2019 Feb 21; 22(4). PMID: 30783387    Free PMC article.
Triple-negative breast cancer: the reality in Chile and in Latin America.
Christian Caglevic, Jaime Anabalón, +6 authors, Mauricio Mahave.
Ecancermedicalscience, 2019 Feb 23; 13. PMID: 30792810    Free PMC article.
Neighborhood Social Determinants of Triple Negative Breast Cancer.
Fokhrul Hossain, Denise Danos, +8 authors, Richard Scribner.
Front Public Health, 2019 Mar 06; 7. PMID: 30834239    Free PMC article.
Long non-coding RNAs: Functional regulatory players in breast cancer.
Rana Ahmed Youness, Mohamed Zakaria Gad.
Noncoding RNA Res, 2019 Mar 21; 4(1). PMID: 30891536    Free PMC article.
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MFAP5 promotes basal-like breast cancer progression by activating the EMT program.
Yanmei Wu, Ping Wu, +3 authors, Weiqiang Zheng.
Cell Biosci, 2019 Mar 23; 9. PMID: 30899449    Free PMC article.
Personalized chemotherapy in triple-negative breast cancer: are we ready for prime time?
Romualdo Barroso-Sousa, Geoffrey I Shapiro, Sara M Tolaney.
Stem Cell Investig, 2019 Apr 13; 6. PMID: 30976601    Free PMC article.
High Expression of DEPDC1 Promotes Malignant Phenotypes of Breast Cancer Cells and Predicts Poor Prognosis in Patients With Breast Cancer.
Huishan Zhao, Mingwei Yu, +5 authors, Cuifang Hao.
Front Oncol, 2019 Apr 30; 9. PMID: 31032225    Free PMC article.
Increased systemic immune-inflammation index independently predicts poor survival for hormone receptor-negative, HER2-positive breast cancer patients.
Yi Sun, Wenqiang Li, +3 authors, Jinming Yu.
Cancer Manag Res, 2019 May 23; 11. PMID: 31114357    Free PMC article.
Small RNA sequencing reveals a novel tsRNA-26576 mediating tumorigenesis of breast cancer.
Jun Zhou, Fang Wan, +2 authors, Xuan Zhu.
Cancer Manag Res, 2019 May 24; 11. PMID: 31118807    Free PMC article.
Novel Prognostic Markers in Triple-Negative Breast Cancer Discovered by MALDI-Mass Spectrometry Imaging.
Leo Phillips, Anthony J Gill, Robert C Baxter.
Front Oncol, 2019 May 30; 9. PMID: 31139569    Free PMC article.
Correlation analysis between ultrasonography and mammography with other risk factors related to breast cancer.
Wenxiao Zhang, Cui Xu, +3 authors, Min Wang.
Oncol Lett, 2019 Jun 13; 17(6). PMID: 31186771    Free PMC article.
Prognostic significance of systemic immune-inflammation index in triple-negative breast cancer.
Jingxin Liu, Zhangzhen Shi, +2 authors, Kailiang Cheng.
Cancer Manag Res, 2019 Jun 14; 11. PMID: 31191009    Free PMC article.
Correlation of CD8+ Expression, Foxp3+ Expression, and CD8+/Foxp3+ Ratio with Triple Negative Breast Cancer Stage in Sanglah General Hospital.
I Wayan Sudarsa, Dewa Gede Subawa, Putu Anda Tusta Adiputra, Ida Bagus Tjakra Wibawa Manuaba.
Open Access Maced J Med Sci, 2019 Jun 19; 7(10). PMID: 31210806    Free PMC article.
HMGB3 silence inhibits breast cancer cell proliferation and tumor growth by interacting with hypoxia-inducible factor 1α.
Jun Gu, Tao Xu, +2 authors, Hai-Yan Chen.
Cancer Manag Res, 2019 Jun 20; 11. PMID: 31213919    Free PMC article.
Homoharringtonine, an approved anti-leukemia drug, suppresses triple negative breast cancer growth through a rapid reduction of anti-apoptotic protein abundance.
Mohamad Yakhni, Arnaud Briat, +6 authors, Nina Radosevic-Robin.
Am J Cancer Res, 2019 Jun 21; 9(5). PMID: 31218111    Free PMC article.
Androgen Receptor Expression and Association With Distant Disease-Free Survival in Triple Negative Breast Cancer: Analysis of 263 Patients Treated With Standard Therapy for Stage I-III Disease.
Maria Vittoria Dieci, Vassilena Tsvetkova, +16 authors, Valentina Guarneri.
Front Oncol, 2019 Jun 28; 9. PMID: 31245286    Free PMC article.
Decoding Immune Heterogeneity of Triple Negative Breast Cancer and Its Association with Systemic Inflammation.
Sandra Romero-Cordoba, Elisabetta Meneghini, +6 authors, Francesca Bianchi.
Cancers (Basel), 2019 Jul 03; 11(7). PMID: 31261762    Free PMC article.
Identification of potential key genes and pathways predicting pathogenesis and prognosis for triple-negative breast cancer.
Xuemei Lv, Miao He, +12 authors, Minjie Wei.
Cancer Cell Int, 2019 Jul 13; 19. PMID: 31297036    Free PMC article.
TUFT1 Promotes Triple Negative Breast Cancer Metastasis, Stemness, and Chemoresistance by Up-Regulating the Rac1/β-Catenin Pathway.
Weiguang Liu, Guanglei Chen, +6 authors, Bo Chen.
Front Oncol, 2019 Jul 25; 9. PMID: 31338333    Free PMC article.
Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells.
Petra Gener, Diana Rafael, +8 authors, Simó Schwartz.
Cancers (Basel), 2019 Jul 31; 11(8). PMID: 31357505    Free PMC article.
Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype.
M V Giuli, E Giuliani, +2 authors, S Checquolo.
J Oncol, 2019 Aug 06; 2019. PMID: 31379945    Free PMC article.
Ecotropic virus integration-1 and calreticulin as novel prognostic markers in triple-negative breast cancer: A retrospective cohort study.
Dongning He, Lei Wu, +3 authors, Youhong Juang.
Oncol Lett, 2019 Aug 20; 18(2). PMID: 31423253    Free PMC article.
Atezolizumab potentiates Tcell-mediated cytotoxicity and coordinates with FAK to suppress cell invasion and motility in PD-L1+ triple negative breast cancer cells.
Nishant Mohan, Salman Hosain, +5 authors, Wen Jin Wu.
Oncoimmunology, 2019 Aug 21; 8(9). PMID: 31428520    Free PMC article.
A multivariate Th17 metagene for prognostic stratification in T cell non-inflamed triple negative breast cancer.
L Faucheux, M Grandclaudon, +10 authors, V Soumelis.
Oncoimmunology, 2019 Aug 21; 8(9). PMID: 31428522    Free PMC article.
High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis.
Jingping Yuan, Xuehui Shi, +4 authors, Honglin Yan.
Oncol Lett, 2019 Aug 28; 18(3). PMID: 31452802    Free PMC article.
Preparation of pentagamaboronon-0 and its fructose and sorbitol complexes as boron carrier for boron neutron capture therapy (BNCT) application.
Ratna Asmah Susidarti, Rohmad Yudi Utomo, +5 authors, Edy Meiyanto.
Res Pharm Sci, 2019 Sep 14; 14(4). PMID: 31516505    Free PMC article.
Long non-coding RNA DRHC inhibits the proliferation of cancer cells in triple negative breast cancer by downregulating long non-coding RNA HOTAIR.
Fusheng Yu, Lei Wang, Bowen Zhang.
Oncol Lett, 2019 Sep 14; 18(4). PMID: 31516593    Free PMC article.
Synergistically Enhanced Inhibitory Effects of Pullulan Nanoparticle-Mediated Co-Delivery of Lovastatin and Doxorubicin to Triple-Negative Breast Cancer Cells.
Di Wu, Yao Chen, +9 authors, Xiyun Deng.
Nanoscale Res Lett, 2019 Sep 15; 14(1). PMID: 31520223    Free PMC article.
Stem Cells and Cellular Origins of Breast Cancer: Updates in the Rationale, Controversies, and Therapeutic Implications.
Jiaojiao Zhou, Qishan Chen, +3 authors, Yiding Chen.
Front Oncol, 2019 Sep 27; 9. PMID: 31555586    Free PMC article.
Obesity and triple-negative-breast-cancer: Is apelin a new key target?
Florian Gourgue, Lionel Mignion, +12 authors, Patrice D Cani.
J Cell Mol Med, 2020 Jul 19;. PMID: 32681609    Free PMC article.
[Preparation of warangalone-loaded liposomes and its inhibitory effect on breast cancer cells].
Lianzhi Mao, Huiping Liu, +4 authors, Suxia Sun.
Nan Fang Yi Ke Da Xue Xue Bao, 2020 Sep 09; 40(6). PMID: 32895205    Free PMC article.
A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer.
Ye Du, Na Wei, +2 authors, Dong Song.
Cell Death Dis, 2020 Sep 11; 11(9). PMID: 32908121    Free PMC article.
M2 macrophage-induced lncRNA PCAT6 facilitates tumorigenesis and angiogenesis of triple-negative breast cancer through modulation of VEGFR2.
Fang Dong, Shengnan Ruan, +5 authors, Qiong Wang.
Cell Death Dis, 2020 Sep 11; 11(9). PMID: 32908134    Free PMC article.
Heparanase from triple‑negative breast cancer and platelets acts as an enhancer of metastasis.
Wen-Jing Yang, Gan-Lin Zhang, +5 authors, Guo-Wang Yang.
Int J Oncol, 2020 Sep 19; 57(4). PMID: 32945393    Free PMC article.
Exploiting DNA repair defects in triple negative breast cancer to improve cell killing.
Kevin J Lee, Elise Mann, +3 authors, Natalie R Gassman.
Ther Adv Med Oncol, 2020 Oct 01; 12. PMID: 32994807    Free PMC article.
Penetrable Nanoplatform for "Cold" Tumor Immune Microenvironment Reeducation.
Qinjun Chen, Yongqing He, +13 authors, Chen Jiang.
Adv Sci (Weinh), 2020 Oct 01; 7(17). PMID: 32995118    Free PMC article.
Mechanistic insights into the activation of ester prodrugs of 666-15.
Fuchun Xie, Pedro Martín-Acosta, Bingbing X Li, Xiangshu Xiao.
Bioorg Med Chem Lett, 2020 Jul 31; 30(19). PMID: 32730943    Free PMC article.
Chloride intracellular channel protein 2: prognostic marker and correlation with PD-1/PD-L1 in breast cancer.
Tao Xu, Zhi Wang, +3 authors, Xingrui Li.
Aging (Albany NY), 2020 Sep 12; 12(17). PMID: 32915772    Free PMC article.
A Screened GPR1 Peptide Exerts Antitumor Effects on Triple-Negative Breast Cancer.
Chen Huang, Xiao-Yong Dai, +6 authors, Jian V Zhang.
Mol Ther Oncolytics, 2020 Oct 03; 18. PMID: 33005727    Free PMC article.
Positive progress: current and evolving role of immune checkpoint inhibitors in metastatic triple-negative breast cancer.
Christine E Simmons, Christine Brezden-Masley, +2 authors, Anil Abraham Joy.
Ther Adv Med Oncol, 2020 Oct 06; 12. PMID: 33014143    Free PMC article.
Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea.
Petra J Pederson, Shengxin Cai, +6 authors, Robert H Cichewicz.
J Nat Prod, 2020 Jul 11; 83(7). PMID: 32649211    Free PMC article.
Transcriptome-Based Network Analysis Unveils Eight Immune-Related Genes as Molecular Signatures in the Immunomodulatory Subtype of Triple-Negative Breast Cancer.
Jinguo Zhang, Li Wang, +4 authors, Guoxiong Xu.
Front Oncol, 2020 Oct 13; 10. PMID: 33042828    Free PMC article.
Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling.
Diego A Pedroza, Venkatesh Rajamanickam, +3 authors, Rajkumar Lakshmanaswamy.
Br J Cancer, 2020 Jul 25; 123(8). PMID: 32704174    Free PMC article.
Manumycin polyketides act as molecular glues between UBR7 and P53.
Yosuke Isobe, Mikiko Okumura, +10 authors, Daniel K Nomura.
Nat Chem Biol, 2020 Jun 24; 16(11). PMID: 32572277    Free PMC article.
USP6NL mediated by LINC00689/miR-142-3p promotes the development of triple-negative breast cancer.
Teng Ma, Huaidong Liu, +5 authors, Lin Zhang.
BMC Cancer, 2020 Oct 16; 20(1). PMID: 33054738    Free PMC article.
Expression pattern analysis and drug differential sensitivity of cancer-associated fibroblasts in triple-negative breast cancer.
Qilong Li, Mohan Li, +2 authors, Shiliang Ma.
Transl Oncol, 2020 Oct 18; 14(1). PMID: 33069102    Free PMC article.
Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies.
Antonio Marra, Dario Trapani, +2 authors, Giuseppe Curigliano.
NPJ Breast Cancer, 2020 Oct 23; 6. PMID: 33088912    Free PMC article.
Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer.
Reid T Powell, Abena Redwood, +21 authors, Helen Piwnica-Worms.
Sci Rep, 2020 Oct 23; 10(1). PMID: 33087803    Free PMC article.
Perspectives on Triple-Negative Breast Cancer: Current Treatment Strategies, Unmet Needs, and Potential Targets for Future Therapies.
Gagan K Gupta, Amber L Collier, +13 authors, Amy H Tang.
Cancers (Basel), 2020 Aug 28; 12(9). PMID: 32846967    Free PMC article.
Radiation induces an inflammatory response that results in STAT3-dependent changes in cellular plasticity and radioresistance of breast cancer stem-like cells.
Kimberly M Arnold, Lynn M Opdenaker, +2 authors, Jennifer Sims-Mourtada.
Int J Radiat Biol, 2019 Dec 19; 96(4). PMID: 31850822    Free PMC article.
Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner.
Johanna Rieckhoff, Felix Meyer, +7 authors, Ann Christin Parplys.
Cancers (Basel), 2020 Oct 03; 12(10). PMID: 33003585    Free PMC article.
Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis.
Andrew L Wishart, Sydney J Conner, +8 authors, Madeleine J Oudin.
Sci Adv, 2020 Oct 23; 6(43). PMID: 33087348    Free PMC article.
Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis.
Lu Xu, Jing-Lei Qu, +9 authors, Yue-E Teng.
Oncol Rep, 2020 Oct 31; 44(6). PMID: 33125141    Free PMC article.
Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.
Chengheng Liao, Yang Zhang, +15 authors, Qing Zhang.
Cancer Discov, 2020 Jul 22; 10(11). PMID: 32690540    Free PMC article.
Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer.
Daniel R Goulet, Joseph P Foster, +9 authors, Gary L Johnson.
Mol Cancer Res, 2020 Aug 06; 18(11). PMID: 32753473    Free PMC article.
DUSP9-mediated reduction of pERK1/2 supports cancer stem cell-like traits and promotes triple negative breast cancer.
Thalia Jimenez, Albert Barrios, +8 authors, Shehla Pervin.
Am J Cancer Res, 2020 Nov 10; 10(10). PMID: 33163285    Free PMC article.
Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer.
Lihan Zhao, Manali Rupji, +5 authors, Ritu Aneja.
Sci Rep, 2020 Nov 07; 10(1). PMID: 33154433    Free PMC article.
Overexpression of lncRNA TATDN1 Promotes Cancer Cell Proliferation in Triple Negative Breast Cancer by Regulating miR-26b Methylation.
Quanyi Long, Hongjiang Li, Yuan Fan, Jia Zhang.
Cancer Manag Res, 2020 Nov 17; 12. PMID: 33192097    Free PMC article.
Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem.
Feifan Zhou, Meng Wang, +2 authors, Wei R Chen.
Biomaterials, 2020 Sep 30; 265. PMID: 32992117    Free PMC article.
A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity.
Annachiara Sarnella, Giuliana D'Avino, +5 authors, Antonella Zannetti.
Int J Mol Sci, 2020 Nov 14; 21(21). PMID: 33182416    Free PMC article.