Review
. 2016 Jun; 100(2):275-90.
doi: 10.1189/jlb.5RI0116-013RR.

Combinatorial approach to cancer immunotherapy: strength in numbers

Anna E Vilgelm 1 Douglas B Johnson 2 Ann Richmond 3 
Affiliations
  • PMID: 27256570
  •     180 References
  •     43 citations

Abstract

Immune-checkpoint blockade therapy with antibodies targeting CTLA-4 and PD-1 has revolutionized melanoma treatment by eliciting responses that can be remarkably durable and is now advancing to other malignancies. However, not all patients respond to immune-checkpoint inhibitors. Extensive preclinical evidence suggests that combining immune-checkpoint inhibitors with other anti-cancer treatments can greatly improve the therapeutic benefit. The first clinical success of the combinatorial approach to cancer immunotherapy was demonstrated using a dual-checkpoint blockade with CTLA-4 and PD-1 inhibitors, which resulted in accelerated FDA approval of this therapeutic regimen. In this review, we discuss the combinations of current and emerging immunotherapeutic agents in clinical and preclinical development and summarize the insights into potential mechanisms of synergistic anti-tumor activity gained from animal studies. These promising combinatorial partners for the immune-checkpoint blockade include therapeutics targeting additional inhibitory receptors of T cells, such as TIM-3, LAG-3, TIGIT, and BTLA, and agonists of T cell costimulatory receptors 4-1BB, OX40, and GITR, as well as agents that promote cancer cell recognition by the immune system, such as tumor vaccines, IDO inhibitors, and agonists of the CD40 receptor of APCs. We also review the therapeutic potential of regimens combining the immune-checkpoint blockade with therapeutic interventions that have been shown to enhance immunogenicity of cancer cells, including oncolytic viruses, RT, epigenetic therapy, and senescence-inducing therapy.

Keywords: immune checkpoints; immunogenic cell death; melanoma; senescence.

Systemic antitumor immunity in experimental brain tumor therapy using a multimutated, replication-competent herpes simplex virus.
T Todo, S D Rabkin, +4 authors, R L Martuza.
Hum Gene Ther, 1999 Dec 10; 10(17). PMID: 10584921
Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells.
P Lane.
J Exp Med, 2000 Jan 19; 191(2). PMID: 10637265    Free PMC article.
Review.
Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation.
P Hwu, M X Du, +3 authors, H A Young.
J Immunol, 2000 Mar 22; 164(7). PMID: 10725715
Highly Cited.
Immunohistochemical analysis of primary breast tumors and tumor-draining lymph nodes by means of the T-cell costimulatory molecule OX-40.
T Ramstad, L Lawnicki, J Vetto, A Weinberg.
Am J Surg, 2000 Aug 10; 179(5). PMID: 10930490
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
G J Freeman, A J Long, +16 authors, T Honjo.
J Exp Med, 2000 Oct 04; 192(7). PMID: 11015443    Free PMC article.
Highly Cited.
Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors.
W J Magner, A L Kazim, +6 authors, T B Tomasi.
J Immunol, 2000 Dec 20; 165(12). PMID: 11120829
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
C C Stamper, Y Zhang, +7 authors, L Mosyak.
Nature, 2001 Mar 30; 410(6828). PMID: 11279502
Highly Cited.
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.
Jun Shimizu, Sayuri Yamazaki, +2 authors, Shimon Sakaguchi.
Nat Immunol, 2002 Jan 29; 3(2). PMID: 11812990
Highly Cited.
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.
Laurent Monney, Catherine A Sabatos, +9 authors, Vijay K Kuchroo.
Nature, 2002 Feb 02; 415(6871). PMID: 11823861
Highly Cited.
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.
Rebecca S McHugh, Matthew J Whitters, +4 authors, Michael C Byrne.
Immunity, 2002 Mar 01; 16(2). PMID: 11869690
Highly Cited.
T-cell regulation by CD28 and CTLA-4.
M L Alegre, K A Frauwirth, C B Thompson.
Nat Rev Immunol, 2002 Mar 22; 1(3). PMID: 11905831
Highly Cited. Review.
Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134).
John K Petty, Ken He, +2 authors, Andrew D Weinberg.
Am J Surg, 2002 May 30; 183(5). PMID: 12034383
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Haidong Dong, Scott E Strome, +10 authors, Lieping Chen.
Nat Med, 2002 Jul 02; 8(8). PMID: 12091876
Highly Cited.
5-aza-2'-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications.
Sandra Coral, Luca Sigalotti, +7 authors, Michele Maio.
Clin Cancer Res, 2002 Aug 13; 8(8). PMID: 12171902
Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.
Andrew L Mellor, Babak Baban, +6 authors, David H Munn.
J Immunol, 2003 Aug 07; 171(4). PMID: 12902462
Highly Cited.
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase.
Catherine Uyttenhove, Luc Pilotte, +5 authors, Benoît J Van den Eynde.
Nat Med, 2003 Sep 23; 9(10). PMID: 14502282
Highly Cited.
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.
Masahide Tone, Yukiko Tone, +4 authors, Herman Waldmann.
Proc Natl Acad Sci U S A, 2003 Nov 11; 100(25). PMID: 14608036    Free PMC article.
T-cell activation marker expression on tumor-infiltrating lymphocytes as prognostic factor in cutaneous malignant melanoma.
Andrea Ladányi, Beáta Somlai, +3 authors, József Tímár.
Clin Cancer Res, 2004 Feb 05; 10(2). PMID: 14760073
Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens.
Iñigo Tirapu, Ainhoa Arina, +7 authors, Ignacio Melero.
Int J Cancer, 2004 Apr 01; 110(1). PMID: 15054868
Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo.
Creg J Workman, Linda S Cauley, +3 authors, Dario A A Vignali.
J Immunol, 2004 Apr 22; 172(9). PMID: 15100286
B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.
Tsvetelina Pentcheva-Hoang, Jackson G Egen, Kathleen Wojnoonski, James P Allison.
Immunity, 2004 Sep 11; 21(3). PMID: 15357951
Highly Cited.
Role of LAG-3 in regulatory T cells.
Ching-Tai Huang, Creg J Workman, +11 authors, Dario A A Vignali.
Immunity, 2004 Oct 16; 21(4). PMID: 15485628
Highly Cited.
Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer.
Sandra Demaria, Noriko Kawashima, +4 authors, Silvia C Formenti.
Clin Cancer Res, 2005 Feb 11; 11(2 Pt 1). PMID: 15701862
Highly Cited.
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.
Alexander J Muller, James B DuHadaway, +2 authors, George C Prendergast.
Nat Med, 2005 Feb 16; 11(3). PMID: 15711557
Highly Cited.
Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate.
Sorin Armeanu, Michael Bitzer, +9 authors, Helmut R Salih.
Cancer Res, 2005 Jul 19; 65(14). PMID: 16024634
Highly Cited.
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.
Chen Zhu, Ana C Anderson, +6 authors, Vijay K Kuchroo.
Nat Immunol, 2005 Nov 16; 6(12). PMID: 16286920
Highly Cited.
Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B.
Søren Skov, Marianne Terndrup Pedersen, +3 authors, Niels Odum.
Cancer Res, 2005 Dec 03; 65(23). PMID: 16322264
Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients.
Maher K Gandhi, Eleanore Lambley, +7 authors, Rajiv Khanna.
Blood, 2006 Jun 08; 108(7). PMID: 16757686
Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity.
Ergun Kocak, Kenneth Lute, +8 authors, Yang Liu.
Cancer Res, 2006 Jul 20; 66(14). PMID: 16849577
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412.
Ganesh Suntharalingam, Meghan R Perry, +4 authors, Nicki Panoskaltsis.
N Engl J Med, 2006 Aug 16; 355(10). PMID: 16908486
Highly Cited.
LAG-3, a novel lymphocyte activation gene closely related to CD4.
F Triebel, S Jitsukawa, +4 authors, T Hercend.
J Exp Med, 1990 May 01; 171(5). PMID: 1692078    Free PMC article.
Highly Cited.
Up-regulation of HLA class-I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acid.
María de Lourdes Mora-García, Alfonso Duenas-González, +10 authors, Alberto Monroy-García.
J Transl Med, 2006 Dec 29; 4. PMID: 17192185    Free PMC article.
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.
Wen Xue, Lars Zender, +5 authors, Scott W Lowe.
Nature, 2007 Jan 26; 445(7128). PMID: 17251933    Free PMC article.
Highly Cited.
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.
Liguo Niu, Simona Strahotin, +9 authors, Robert S Mittler.
J Immunol, 2007 Mar 21; 178(7). PMID: 17371976    Free PMC article.
Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications.
Ester Fonsatti, Hugues J M Nicolay, +7 authors, Michele Maio.
Clin Cancer Res, 2007 Jun 05; 13(11). PMID: 17545540
Established B16 tumors are rejected following treatment with GM-CSF-secreting tumor cell immunotherapy in combination with anti-4-1BB mAb.
Betty Li, Jianmin Lin, +2 authors, Karin Jooss.
Clin Immunol, 2007 Aug 21; 125(1). PMID: 17706463
Pivotal roles of CD4+ effector T cells in mediating agonistic anti-GITR mAb-induced-immune activation and tumor immunity in CT26 tumors.
Pengfei Zhou, Lawrence L'italien, Douglas Hodges, Xiao Min Schebye.
J Immunol, 2007 Nov 21; 179(11). PMID: 18025180
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection.
Silvia Piconese, Barbara Valzasina, Mario P Colombo.
J Exp Med, 2008 Mar 26; 205(4). PMID: 18362171    Free PMC article.
Highly Cited.
The administration of IL-12/GM-CSF and Ig-4-1BB ligand markedly decreases murine floor of mouth squamous cell cancer.
Nithin D Adappa, Chi-Kwang Sung, +3 authors, Edward J Shin.
Otolaryngol Head Neck Surg, 2008 Aug 30; 139(3). PMID: 18722228
Treatment of ovarian cancer cell lines with 5-aza-2'-deoxycytidine upregulates the expression of cancer-testis antigens and class I major histocompatibility complex-encoded molecules.
Sara J Adair, Kevin T Hogan.
Cancer Immunol Immunother, 2008 Sep 16; 58(4). PMID: 18791715
CTLA-4 control over Foxp3+ regulatory T cell function.
Kajsa Wing, Yasushi Onishi, +5 authors, Shimon Sakaguchi.
Science, 2008 Oct 11; 322(5899). PMID: 18845758
Highly Cited.
T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy.
Roch Houot, Ronald Levy.
Blood, 2008 Oct 23; 113(15). PMID: 18941113    Free PMC article.
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Xin Yu, Kristin Harden, +9 authors, Jane L Grogan.
Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627
Highly Cited.
Senescence-messaging secretome: SMS-ing cellular stress.
Thomas Kuilman, Daniel S Peeper.
Nat Rev Cancer, 2009 Jan 10; 9(2). PMID: 19132009
Highly Cited. Review.
CD28 and CTLA-4 coreceptor expression and signal transduction.
Christopher E Rudd, Alison Taylor, Helga Schneider.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426212    Free PMC article.
Highly Cited. Review.
Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?
Stefan Löb, Alfred Königsrainer, +2 authors, Peter Terness.
Nat Rev Cancer, 2009 May 23; 9(6). PMID: 19461669
Highly Cited. Review.
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion.
Roch Houot, Matthew J Goldstein, +8 authors, Ronald Levy.
Blood, 2009 Jul 31; 114(16). PMID: 19641184    Free PMC article.
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody.
M Zahidunnabi Dewan, Ashley E Galloway, +4 authors, Sandra Demaria.
Clin Cancer Res, 2009 Aug 27; 15(17). PMID: 19706802    Free PMC article.
Highly Cited.
The senescence-associated secretory phenotype: the dark side of tumor suppression.
Jean-Philippe Coppé, Pierre-Yves Desprez, Ana Krtolica, Judith Campisi.
Annu Rev Pathol, 2010 Jan 19; 5. PMID: 20078217    Free PMC article.
Highly Cited. Review.
Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival.
Geoffrey Y Ku, Jianda Yuan, +7 authors, Jedd D Wolchok.
Cancer, 2010 Feb 10; 116(7). PMID: 20143434    Free PMC article.
Highly Cited.
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
Michael A Curran, Welby Montalvo, Hideo Yagita, James P Allison.
Proc Natl Acad Sci U S A, 2010 Feb 18; 107(9). PMID: 20160101    Free PMC article.
Highly Cited.
Circulating mitochondrial DAMPs cause inflammatory responses to injury.
Qin Zhang, Mustafa Raoof, +6 authors, Carl J Hauser.
Nature, 2010 Mar 06; 464(7285). PMID: 20203610    Free PMC article.
Highly Cited.
The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro.
Jürgen Sonnemann, Stephanie Gressmann, +3 authors, James F Beck.
Cancer Chemother Pharmacol, 2010 Mar 12; 66(3). PMID: 20221600
Control of immunity by the TNFR-related molecule OX40 (CD134).
Michael Croft.
Annu Rev Immunol, 2010 Mar 24; 28. PMID: 20307208    Free PMC article.
Highly Cited. Review.
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.
Juan Dubrot, Francisca Milheiro, +11 authors, Ignacio Melero.
Cancer Immunol Immunother, 2010 Mar 26; 59(8). PMID: 20336294
Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer.
Junko Matsuzaki, Sacha Gnjatic, +9 authors, Kunle Odunsi.
Proc Natl Acad Sci U S A, 2010 Apr 14; 107(17). PMID: 20385810    Free PMC article.
Highly Cited.
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation.
Adam D Cohen, David A Schaer, +10 authors, Jedd D Wolchok.
PLoS One, 2010 May 11; 5(5). PMID: 20454651    Free PMC article.
Highly Cited.
Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.
Jun Mitsui, Hiroyoshi Nishikawa, +9 authors, Hiroshi Shiku.
Clin Cancer Res, 2010 May 13; 16(10). PMID: 20460483
Improved survival with ipilimumab in patients with metastatic melanoma.
F Stephen Hodi, Steven J O'Day, +26 authors, Walter J Urba.
N Engl J Med, 2010 Jun 08; 363(8). PMID: 20525992    Free PMC article.
Highly Cited.
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.
Hyun-Tak Jin, Ana C Anderson, +6 authors, Rafi Ahmed.
Proc Natl Acad Sci U S A, 2010 Aug 04; 107(33). PMID: 20679213    Free PMC article.
Highly Cited.
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.
Julien Fourcade, Zhaojun Sun, +6 authors, Hassane M Zarour.
J Exp Med, 2010 Sep 08; 207(10). PMID: 20819923    Free PMC article.
Highly Cited.
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity.
Kaori Sakuishi, Lionel Apetoh, +3 authors, Ana C Anderson.
J Exp Med, 2010 Sep 08; 207(10). PMID: 20819927    Free PMC article.
Highly Cited.
Therapy-induced senescence in cancer.
Jonathan A Ewald, Joshua A Desotelle, George Wilding, David F Jarrard.
J Natl Cancer Inst, 2010 Sep 23; 102(20). PMID: 20858887    Free PMC article.
Highly Cited. Review.
TIM-3: a novel regulatory molecule of alloimmune activation.
Olaf Boenisch, Francesca D'Addio, +14 authors, Nader Najafian.
J Immunol, 2010 Oct 20; 185(10). PMID: 20956339    Free PMC article.
Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies.
Paolo A Ascierto, Ester Simeone, +2 authors, Ignacio Melero.
Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074066
Highly Cited. Review.
4-1BB signaling beyond T cells.
Dass S Vinay, Byoung S Kwon.
Cell Mol Immunol, 2011 Jan 11; 8(4). PMID: 21217771    Free PMC article.
Review.
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.
Qing Zhou, Meghan E Munger, +8 authors, Bruce R Blazar.
Blood, 2011 Mar 10; 117(17). PMID: 21385853    Free PMC article.
Highly Cited.
Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors.
Shin Foong Ngiow, Bianca von Scheidt, +3 authors, Mark J Smyth.
Cancer Res, 2011 Mar 25; 71(10). PMID: 21430066
Highly Cited.
Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production.
Michael A Curran, Myoungjoo Kim, +2 authors, James P Allison.
PLoS One, 2011 May 12; 6(4). PMID: 21559358    Free PMC article.
Highly Cited.
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma.
Caroline Robert, Luc Thomas, +21 authors, Jedd D Wolchok.
N Engl J Med, 2011 Jun 07; 364(26). PMID: 21639810
Highly Cited.
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Tae-Won Kang, Tetyana Yevsa, +22 authors, Lars Zender.
Nature, 2011 Nov 15; 479(7374). PMID: 22080947
Highly Cited.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.
Julien Fourcade, Zhaojun Sun, +7 authors, Hassane M Zarour.
Cancer Res, 2011 Dec 30; 72(4). PMID: 22205715    Free PMC article.
Highly Cited.
Immunologic correlates of the abscopal effect in a patient with melanoma.
Michael A Postow, Margaret K Callahan, +18 authors, Jedd D Wolchok.
N Engl J Med, 2012 Mar 09; 366(10). PMID: 22397654    Free PMC article.
Highly Cited.
Combining immunotherapy and targeted therapies in cancer treatment.
Matthew Vanneman, Glenn Dranoff.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437869    Free PMC article.
Highly Cited. Review.
Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies.
Lisa Hoenicke, Lars Zender.
Carcinogenesis, 2012 Apr 04; 33(6). PMID: 22470164
Review.
Activation of a glioma-specific immune response by oncolytic parvovirus Minute Virus of Mice infection.
S P Grekova, Z Raykov, +2 authors, U Koch.
Cancer Gene Ther, 2012 Apr 28; 19(7). PMID: 22539062
Abscopal effect in a patient with melanoma.
Susan M Hiniker, Daniel S Chen, Susan J Knox.
N Engl J Med, 2012 May 25; 366(21). PMID: 22621637
CD27 signaling increases the frequency of regulatory T cells and promotes tumor growth.
Christina Claus, Carsten Riether, +3 authors, Adrian F Ochsenbein.
Cancer Res, 2012 May 26; 72(14). PMID: 22628427
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127    Free PMC article.
Highly Cited.
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.
Shigeki Chiba, Muhammad Baghdadi, +12 authors, Masahisa Jinushi.
Nat Immunol, 2012 Jul 31; 13(9). PMID: 22842346    Free PMC article.
Highly Cited.
Immunogenic cell death and DAMPs in cancer therapy.
Dmitri V Krysko, Abhishek D Garg, +3 authors, Peter Vandenabeele.
Nat Rev Cancer, 2012 Nov 16; 12(12). PMID: 23151605
Highly Cited. Review.
Immunogenic cell death in cancer therapy.
Guido Kroemer, Lorenzo Galluzzi, Oliver Kepp, Laurence Zitvogel.
Annu Rev Immunol, 2012 Nov 20; 31. PMID: 23157435
Highly Cited. Review.
Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.
Yan Liu, Oriana E Hawkins, +11 authors, Ann Richmond.
EMBO Mol Med, 2012 Nov 28; 5(1). PMID: 23180582    Free PMC article.
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma.
Antoni Ribas, Richard Kefford, +21 authors, Axel Hauschild.
J Clin Oncol, 2013 Jan 09; 31(5). PMID: 23295794    Free PMC article.
Highly Cited.
Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas.
Jing Zeng, Alfred P See, +18 authors, Michael Lim.
Int J Radiat Oncol Biol Phys, 2013 Mar 07; 86(2). PMID: 23462419    Free PMC article.
Highly Cited.
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Lieping Chen, Dallas B Flies.
Nat Rev Immunol, 2013 Mar 09; 13(4). PMID: 23470321    Free PMC article.
Highly Cited. Review.
Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma.
Stephen R Goding, Kyle A Wilson, +7 authors, Paul Andrew Antony.
J Immunol, 2013 Mar 29; 190(9). PMID: 23536636    Free PMC article.
Highly Cited.
Hepatotoxicity with combination of vemurafenib and ipilimumab.
Antoni Ribas, F Stephen Hodi, +2 authors, Jedd Wolchok.
N Engl J Med, 2013 Apr 05; 368(14). PMID: 23550685
Highly Cited.
Danger signalling during cancer cell death: origins, plasticity and regulation.
A D Garg, S Martin, J Golab, P Agostinis.
Cell Death Differ, 2013 May 21; 21(1). PMID: 23686135    Free PMC article.
Highly Cited. Review.
Nivolumab plus ipilimumab in advanced melanoma.
Jedd D Wolchok, Harriet Kluger, +21 authors, Mario Sznol.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724867    Free PMC article.
Highly Cited.
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.
Aurélien Marabelle, Holbrook Kohrt, +13 authors, Ronald Levy.
J Clin Invest, 2013 Jun 04; 123(6). PMID: 23728179    Free PMC article.
Highly Cited.
TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer.
Kaori Sakuishi, Shin Foong Ngiow, +4 authors, Ana C Anderson.
Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734331    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer.
Jaikumar Duraiswamy, Gordon J Freeman, George Coukos.
Cancer Res, 2013 Aug 27; 73(23). PMID: 23975756    Free PMC article.
Highly Cited.
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.
Jeffrey S Weber, Ragini Reiney Kudchadkar, +11 authors, Y Ann Chen.
J Clin Oncol, 2013 Oct 23; 31(34). PMID: 24145345    Free PMC article.
Highly Cited.
An intact immune system is required for the anticancer activities of histone deacetylase inhibitors.
Alison C West, Stephen R Mattarollo, +4 authors, Ricky W Johnstone.
Cancer Res, 2013 Oct 26; 73(24). PMID: 24158093
OX40 is a potent immune-stimulating target in late-stage cancer patients.
Brendan D Curti, Magdalena Kovacsovics-Bankowski, +20 authors, Andrew D Weinberg.
Cancer Res, 2013 Nov 02; 73(24). PMID: 24177180    Free PMC article.
Highly Cited.
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.
Liufu Deng, Hua Liang, +4 authors, Yang-Xin Fu.
J Clin Invest, 2014 Jan 03; 124(2). PMID: 24382348    Free PMC article.
Highly Cited.
Epigenetic drugs as immunomodulators for combination therapies in solid tumors.
Luca Sigalotti, Elisabetta Fratta, Sandra Coral, Michele Maio.
Pharmacol Ther, 2014 Jan 05; 142(3). PMID: 24384533
Review.
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs.
Lei Lu, Xiaobing Xu, +3 authors, Xuan Wang.
J Transl Med, 2014 Feb 08; 12. PMID: 24502656    Free PMC article.
PD-1 blockade and OX40 triggering synergistically protects against tumor growth in a murine model of ovarian cancer.
Zhiqiang Guo, Xin Wang, +3 authors, Shulan Zhang.
PLoS One, 2014 Mar 04; 9(2). PMID: 24586709    Free PMC article.
Highly Cited.
Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy.
Dmitriy Zamarin, Rikke B Holmgaard, +6 authors, James P Allison.
Sci Transl Med, 2014 Mar 07; 6(226). PMID: 24598590    Free PMC article.
Highly Cited.
Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.
Derek Ng Tang, Yu Shen, +5 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 1(4). PMID: 24777852    Free PMC article.
Highly Cited.
Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity.
William L Redmond, Stefanie N Linch, Melissa J Kasiewicz.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778278    Free PMC article.
Agonistic anti-CD137 antibody treatment leads to antitumor response in mice with liver cancer.
Vanessa Gauttier, Jean-Paul Judor, +3 authors, Sophie Conchon.
Int J Cancer, 2014 May 03; 135(12). PMID: 24789574
Tim-3: an emerging target in the cancer immunotherapy landscape.
Ana C Anderson.
Cancer Immunol Res, 2014 May 06; 2(5). PMID: 24795351
Highly Cited. Review.
Therapeutic vaccines for cancer: an overview of clinical trials.
Ignacio Melero, Gustav Gaudernack, +8 authors, Håkan Mellstedt.
Nat Rev Clin Oncol, 2014 Jul 09; 11(9). PMID: 25001465
Highly Cited. Review.
Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.
Jinpu Yu, Yue Wang, +6 authors, Xiubao Ren.
J Immunol, 2014 Jul 27; 193(5). PMID: 25063873    Free PMC article.
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.
KiBem Kim, Andrew D Skora, +8 authors, Shibin Zhou.
Proc Natl Acad Sci U S A, 2014 Jul 30; 111(32). PMID: 25071169    Free PMC article.
Highly Cited.
Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy.
Antonio M Grimaldi, Ester Simeone, +15 authors, Paolo A Ascierto.
Oncoimmunology, 2014 Aug 02; 3. PMID: 25083318    Free PMC article.
Highly Cited.
Newcastle disease virotherapy induces long-term survival and tumor-specific immune memory in orthotopic glioma through the induction of immunogenic cell death.
Carolien A Koks, Abhishek D Garg, +7 authors, Stefaan W Van Gool.
Int J Cancer, 2014 Sep 12; 136(5). PMID: 25208916
Highly Cited.
Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.
Pia Kvistborg, Daisy Philips, +13 authors, Ton N Schumacher.
Sci Transl Med, 2014 Sep 19; 6(254). PMID: 25232180
Highly Cited.
Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma.
Georgina V Long, Daniil Stroyakovskiy, +32 authors, Keith Flaherty.
N Engl J Med, 2014 Sep 30; 371(20). PMID: 25265492
Highly Cited.
Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade.
Simon J Dovedi, Amy L Adlard, +11 authors, Tim M Illidge.
Cancer Res, 2014 Oct 03; 74(19). PMID: 25274032
Highly Cited.
Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo.
Nicholas M Durham, Christopher J Nirschl, +4 authors, Charles G Drake.
PLoS One, 2014 Nov 06; 9(11). PMID: 25372844    Free PMC article.
Combination of 4-1BB agonist and PD-1 antagonist promotes antitumor effector/memory CD8 T cells in a poorly immunogenic tumor model.
Shihao Chen, Li-Fen Lee, +12 authors, John C Lin.
Cancer Immunol Res, 2014 Nov 13; 3(2). PMID: 25387892
Highly Cited.
Universes collide: combining immunotherapy with targeted therapy for cancer.
Jennifer A Wargo, Zachary A Cooper, Keith T Flaherty.
Cancer Discov, 2014 Nov 15; 4(12). PMID: 25395294    Free PMC article.
Review.
Nivolumab in previously untreated melanoma without BRAF mutation.
Caroline Robert, Georgina V Long, +25 authors, Paolo A Ascierto.
N Engl J Med, 2014 Nov 18; 372(4). PMID: 25399552
Highly Cited.
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Sarah Buchan, Teresa Manzo, +12 authors, Ronjon Chakraverty.
J Immunol, 2014 Nov 19; 194(1). PMID: 25404365    Free PMC article.
Genetic basis for clinical response to CTLA-4 blockade in melanoma.
Alexandra Snyder, Vladimir Makarov, +18 authors, Timothy A Chan.
N Engl J Med, 2014 Nov 20; 371(23). PMID: 25409260    Free PMC article.
Highly Cited.
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
Roy S Herbst, Jean-Charles Soria, +19 authors, F Stephen Hodi.
Nature, 2014 Nov 28; 515(7528). PMID: 25428504    Free PMC article.
Highly Cited.
PD-1 blockade induces responses by inhibiting adaptive immune resistance.
Paul C Tumeh, Christina L Harview, +23 authors, Antoni Ribas.
Nature, 2014 Nov 28; 515(7528). PMID: 25428505    Free PMC article.
Highly Cited.
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.
Robert J Johnston, Laetitia Comps-Agrar, +9 authors, Jane L Grogan.
Cancer Cell, 2014 Dec 04; 26(6). PMID: 25465800
Highly Cited.
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen.
Andrew B Sharabi, Christopher J Nirschl, +5 authors, Charles G Drake.
Cancer Immunol Res, 2014 Dec 21; 3(4). PMID: 25527358    Free PMC article.
Highly Cited.
Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor.
Yoshitaro Shindo, Kiyoshi Yoshimura, +10 authors, Masaaki Oka.
Anticancer Res, 2015 Jan 01; 35(1). PMID: 25550543
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.
Dalil Hannani, Marie Vétizou, +30 authors, Laurence Zitvogel.
Cell Res, 2015 Jan 15; 25(2). PMID: 25582080    Free PMC article.
Highly Cited.
Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment.
Alfred Zippelius, Jens Schreiner, Petra Herzig, Philipp Müller.
Cancer Immunol Res, 2015 Jan 28; 3(3). PMID: 25623164
Genetic basis for clinical response to CTLA-4 blockade.
Ignacio Melero, Juan J Lasarte.
N Engl J Med, 2015 Feb 19; 372(8). PMID: 25693025
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Christina Twyman-Saint Victor, Andrew J Rech, +22 authors, Andy J Minn.
Nature, 2015 Mar 11; 520(7547). PMID: 25754329    Free PMC article.
Highly Cited.
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.
Jeffrey S Weber, Sandra P D'Angelo, +25 authors, James Larkin.
Lancet Oncol, 2015 Mar 22; 16(4). PMID: 25795410
Highly Cited.
An unexpected journey: how cancer immunotherapy has paved the way for an HIV-1 cure.
Kellie N Smith, Franck Housseau.
Discov Med, 2015 Apr 02; 19(104). PMID: 25828527
Review.
The future of immune checkpoint therapy.
Padmanee Sharma, James P Allison.
Science, 2015 Apr 04; 348(6230). PMID: 25838373
Highly Cited. Review.
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.
Joe-Marc Chauvin, Ornella Pagliano, +8 authors, Hassane M Zarour.
J Clin Invest, 2015 Apr 14; 125(5). PMID: 25866972    Free PMC article.
Highly Cited.
Pembrolizumab versus Ipilimumab in Advanced Melanoma.
Caroline Robert, Jacob Schachter, +20 authors, KEYNOTE-006 investigators.
N Engl J Med, 2015 Apr 22; 372(26). PMID: 25891173
Highly Cited.
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.
Michael A Postow, Jason Chesney, +18 authors, F Stephen Hodi.
N Engl J Med, 2015 Apr 22; 372(21). PMID: 25891304    Free PMC article.
Highly Cited.
Trial watch: IDO inhibitors in cancer therapy.
Erika Vacchelli, Fernando Aranda, +7 authors, Lorenzo Galluzzi.
Oncoimmunology, 2015 May 06; 3(10). PMID: 25941578    Free PMC article.
Highly Cited. Review.
Combinatorial strategies for the induction of immunogenic cell death.
Lucillia Bezu, Ligia C Gomes-de-Silva, +6 authors, Guido Kroemer.
Front Immunol, 2015 May 13; 6. PMID: 25964783    Free PMC article.
Highly Cited. Review.
Epigenetics meets immune checkpoints.
Alessia Covre, Sandra Coral, +3 authors, Michele Maio.
Semin Oncol, 2015 May 13; 42(3). PMID: 25965370
Review.
Classifying Cancers Based on T-cell Infiltration and PD-L1.
Michele W L Teng, Shin Foong Ngiow, Antoni Ribas, Mark J Smyth.
Cancer Res, 2015 May 16; 75(11). PMID: 25977340    Free PMC article.
Highly Cited. Review.
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.
Robert H I Andtbacka, Howard L Kaufman, +26 authors, Robert S Coffin.
J Clin Oncol, 2015 May 28; 33(25). PMID: 26014293
Highly Cited.
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.
Julie Brahmer, Karen L Reckamp, +22 authors, David R Spigel.
N Engl J Med, 2015 Jun 02; 373(2). PMID: 26028407    Free PMC article.
Highly Cited.
Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers.
Luisa Carbognin, Sara Pilotto, +11 authors, Giampaolo Tortora.
PLoS One, 2015 Jun 19; 10(6). PMID: 26086854    Free PMC article.
Highly Cited.
4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity.
Todd Bartkowiak, Michael A Curran.
Front Oncol, 2015 Jun 25; 5. PMID: 26106583    Free PMC article.
Highly Cited. Review.
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial.
Antoni Ribas, Igor Puzanov, +33 authors, Adil Daud.
Lancet Oncol, 2015 Jun 28; 16(8). PMID: 26115796    Free PMC article.
Highly Cited.
Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models.
Yan Liu, Oriana E Hawkins, +5 authors, Ann Richmond.
Clin Cancer Res, 2015 Jul 15; 21(23). PMID: 26152738    Free PMC article.
Therapeutic Advances and Treatment Options in Metastatic Melanoma.
Douglas B Johnson, Jeffrey A Sosman.
JAMA Oncol, 2015 Jul 17; 1(3). PMID: 26181188
Review.
CD70: An emerging target in cancer immunotherapy.
J Jacobs, V Deschoolmeester, +6 authors, P Pauwels.
Pharmacol Ther, 2015 Jul 28; 155. PMID: 26213107
Review.
Therapeutic cancer vaccines.
Cornelis J M Melief, Thorbald van Hall, +2 authors, Sjoerd H van der Burg.
J Clin Invest, 2015 Jul 28; 125(9). PMID: 26214521    Free PMC article.
Highly Cited. Review.
HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade.
David M Woods, Andressa L Sodré, +3 authors, Jeffrey Weber.
Cancer Immunol Res, 2015 Aug 25; 3(12). PMID: 26297712    Free PMC article.
Highly Cited.
Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer.
Jitka Fucikova, Irena Moserova, +8 authors, Radek Spisek.
Front Immunol, 2015 Aug 25; 6. PMID: 26300886    Free PMC article.
Review.
Clinical Activity, Toxicity, Biomarkers, and Future Development of CTLA-4 Checkpoint Antagonists.
Margaret K Callahan, Jedd D Wolchok.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320062
Review.
Antagonists of PD-1 and PD-L1 in Cancer Treatment.
Evan J Lipson, Patrick M Forde, +3 authors, Suzanne L Topalian.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320063    Free PMC article.
Highly Cited. Review.
Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators.
Isabelle Le Mercier, J Louise Lines, Randolph J Noelle.
Front Immunol, 2015 Sep 09; 6. PMID: 26347741    Free PMC article.
Highly Cited. Review.
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.
Eliezer M Van Allen, Diana Miao, +19 authors, Levi A Garraway.
Science, 2015 Sep 12; 350(6257). PMID: 26359337    Free PMC article.
Highly Cited.
Emerging immune checkpoints for cancer therapy.
Xiaodong Li, Wenwei Hu, +8 authors, Changping Wu.
Acta Oncol, 2015 Sep 12; 54(10). PMID: 26361073
Review.
Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses.
Anna Vilgelm, Ann Richmond.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405565    Free PMC article.
BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties.
Cara L Haymaker, Richard C Wu, +8 authors, Laszlo G Radvanyi.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405566    Free PMC article.
Antitumor activity of epigenetic immunomodulation combined with CTLA-4 blockade in syngeneic mouse models.
A Covre, S Coral, +8 authors, M Maio.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405573    Free PMC article.
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma.
Robert J Motzer, Bernard Escudier, +25 authors, CheckMate 025 Investigators.
N Engl J Med, 2015 Sep 26; 373(19). PMID: 26406148    Free PMC article.
Highly Cited.
TIGIT predominantly regulates the immune response via regulatory T cells.
Sema Kurtulus, Kaori Sakuishi, +6 authors, Ana C Anderson.
J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413872    Free PMC article.
Highly Cited.
A systematic evaluation of abscopal responses following radiotherapy in patients with metastatic melanoma treated with ipilimumab.
Ravi A Chandra, Tyler J Wilhite, +6 authors, Jonathan D Schoenfeld.
Oncoimmunology, 2015 Oct 10; 4(11). PMID: 26451318    Free PMC article.
Highly Cited.
Checkpoint blockade in combination with cancer vaccines.
Michael A Morse, H Kim Lyerly.
Vaccine, 2015 Oct 21; 33(51). PMID: 26482147
Review.
Fueling the engine and releasing the break: combinational therapy of cancer vaccines and immune checkpoint inhibitors.
Jennifer Kleponis, Richard Skelton, Lei Zheng.
Cancer Biol Med, 2015 Oct 22; 12(3). PMID: 26487965    Free PMC article.
Review.
Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab.
Venky Ramakrishna, Karuna Sundarapandiyan, +3 authors, Tibor Keler.
J Immunother Cancer, 2015 Oct 27; 3. PMID: 26500773    Free PMC article.
Low dose cyclophosphamide: Mechanisms of T cell modulation.
Mutsa Tatenda Madondo, Michael Quinn, Magdalena Plebanski.
Cancer Treat Rev, 2015 Dec 02; 42. PMID: 26620820
Review.
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.
Abhishek D Garg, Lorenzo Galluzzi, +49 authors, Patrizia Agostinis.
Front Immunol, 2015 Dec 05; 6. PMID: 26635802    Free PMC article.
Highly Cited.
Rationale for anti-OX40 cancer immunotherapy.
Sandrine Aspeslagh, Sophie Postel-Vinay, +3 authors, Aurélien Marabelle.
Eur J Cancer, 2015 Dec 10; 52. PMID: 26645943
Highly Cited. Review.
Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment.
Anna E Vilgelm, C Andrew Johnson, +11 authors, Ann Richmond.
J Natl Cancer Inst, 2016 Jan 01; 108(6). PMID: 26719346    Free PMC article.
The Role of Adaptive Immunity in the Efficacy of Targeted Cancer Therapies.
Meng Michelle Xu, Yang Pu, Yuan Zhang, Yang-Xin Fu.
Trends Immunol, 2016 Jan 19; 37(2). PMID: 26778079    Free PMC article.
Review.
Activation of human dendritic cells through CD40 cross-linking.
C Caux, C Massacrier, +4 authors, J Banchereau.
J Exp Med, 1994 Oct 01; 180(4). PMID: 7523569    Free PMC article.
Highly Cited.
CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins.
B Huard, P Prigent, +2 authors, F Triebel.
Eur J Immunol, 1995 Sep 01; 25(9). PMID: 7589152
Enhancement of antitumor immunity by CTLA-4 blockade.
D R Leach, M F Krummel, J P Allison.
Science, 1996 Mar 22; 271(5256). PMID: 8596936
Highly Cited.
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
M Cella, D Scheidegger, +3 authors, G Alber.
J Exp Med, 1996 Aug 01; 184(2). PMID: 8760829    Free PMC article.
Highly Cited.
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.
I Melero, W W Shuford, +5 authors, L Chen.
Nat Med, 1997 Jun 01; 3(6). PMID: 9176498
Highly Cited.
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis.
G Nocentini, L Giunchi, +5 authors, C Riccardi.
Proc Natl Acad Sci U S A, 1997 Jun 10; 94(12). PMID: 9177197    Free PMC article.
Highly Cited.
Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers.
J T Vetto, S Lum, +4 authors, A Weinberg.
Am J Surg, 1997 Oct 27; 174(3). PMID: 9324133
CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase.
H Akiba, H Nakano, +9 authors, K Okumura.
J Biol Chem, 1998 May 28; 273(21). PMID: 9582383
Prevention of allogeneic fetal rejection by tryptophan catabolism.
D H Munn, M Zhou, +5 authors, A L Mellor.
Science, 1998 Aug 26; 281(5380). PMID: 9712583
Highly Cited.
Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy.
Gregory S Alexander, Joshua D Palmer, +8 authors, Bo Lu.
J Hematol Oncol, 2016 Sep 25; 9(1). PMID: 27663515    Free PMC article.
Is There Still Room for Cancer Vaccines at the Era of Checkpoint Inhibitors.
Soumaya Karaki, Marie Anson, +4 authors, Eric Tartour.
Vaccines (Basel), 2016 Nov 10; 4(4). PMID: 27827885    Free PMC article.
Review.
Potential applications of nanoparticles in cancer immunotherapy.
Yimei Jia, Abdelwahab Omri, Lakshmi Krishnan, Michael J McCluskie.
Hum Vaccin Immunother, 2016 Nov 22; 13(1). PMID: 27870598    Free PMC article.
Review.
Biomimetic biodegradable artificial antigen presenting cells synergize with PD-1 blockade to treat melanoma.
A K Kosmides, R A Meyer, +4 authors, J P Schneck.
Biomaterials, 2016 Dec 13; 118. PMID: 27940380    Free PMC article.
Advancing Immune and Cell-Based Therapies Through Imaging.
Vladimir Ponomarev.
Mol Imaging Biol, 2017 Mar 09; 19(3). PMID: 28271366    Free PMC article.
Review.
The Five Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy.
Suneetha Amara, Venkataswarup Tiriveedhi.
Int J Mol Sci, 2017 Mar 18; 18(3). PMID: 28304339    Free PMC article.
Review.
Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro.
Amy H Lin, Christopher G Twitty, +5 authors, Douglas J Jolly.
Mol Ther Nucleic Acids, 2017 Mar 23; 6. PMID: 28325288    Free PMC article.
Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas.
Pilvi Maliniemi, Kirsi Laukkanen, +7 authors, Annamari Ranki.
Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405495    Free PMC article.
Immune System, Friend or Foe of Oncolytic Virotherapy?
Anna C Filley, Mahua Dey.
Front Oncol, 2017 Jun 08; 7. PMID: 28589085    Free PMC article.
Review.
Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants.
Sander Bekeschus, Katrin Rödder, +6 authors, Rajesh Kumar Gandhirajan.
Oxid Med Cell Longev, 2017 Aug 02; 2017. PMID: 28761621    Free PMC article.
Improving radiotherapy in cancer treatment: Promises and challenges.
Helen H W Chen, Macus Tien Kuo.
Oncotarget, 2017 Oct 06; 8(37). PMID: 28977985    Free PMC article.
Review.
MDM2 Antagonists Counteract Drug-Induced DNA Damage.
Anna E Vilgelm, Priscilla Cobb, +12 authors, Ann Richmond.
EBioMedicine, 2017 Oct 17; 24. PMID: 29030058    Free PMC article.
Nanoparticles: augmenting tumor antigen presentation for vaccine and immunotherapy treatments of cancer.
Charles B Chesson, Andrew Zloza.
Nanomedicine (Lond), 2017 Nov 04; 12(23). PMID: 29098928    Free PMC article.
Review.
New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness.
Isabel Corraliza-Gorjón, Beatriz Somovilla-Crespo, +2 authors, Leonor Kremer.
Front Immunol, 2018 Jan 10; 8. PMID: 29312320    Free PMC article.
Review.
Anticancer Mechanisms in Two Murine Bone Marrow-Derived Dendritic Cell Subsets Activated with TLR4 Agonists.
Alexander Bagaev, Aleksey Pichugin, +3 authors, Ravshan I Ataullakhanov.
J Immunol, 2018 Mar 04; 200(8). PMID: 29500244    Free PMC article.
Short- and long-term evolution in our arms race with cancer: Why the war on cancer is winnable.
Jay A Rosenheim.
Evol Appl, 2018 Jun 22; 11(6). PMID: 29928294    Free PMC article.
Targeting the IDO1 pathway in cancer: from bench to bedside.
Ming Liu, Xu Wang, +4 authors, Yong Li.
J Hematol Oncol, 2018 Aug 03; 11(1). PMID: 30068361    Free PMC article.
Highly Cited. Review.
Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effects.
Lien De Beck, Sarah Melhaoui, +5 authors, Ken Maes.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288346    Free PMC article.
Stimulation of natural killer cells with rhCD137 ligand enhances tumor-targeting antibody efficacy in gastric cancer.
Toshihiro Misumi, Kazuaki Tanabe, Nobuaki Fujikuni, Hideki Ohdan.
PLoS One, 2018 Oct 16; 13(10). PMID: 30321186    Free PMC article.
Breaking Therapy Resistance: An Update on Oncolytic Newcastle Disease Virus for Improvements of Cancer Therapy.
Volker Schirrmacher, Stefaan van Gool, Wilfried Stuecker.
Biomedicines, 2019 Sep 05; 7(3). PMID: 31480379    Free PMC article.
Review.
Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment.
Min Yang, Wenwen Du, +9 authors, Binfeng Lu.
Oncoimmunology, 2020 Feb 23; 9(1). PMID: 32076578    Free PMC article.
Blockade of PD-1 and LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-Resident CD8+ TRM Cells and Reduces Ocular Herpes Simplex Infection and Disease in HLA Transgenic Rabbits.
Soumyabrata Roy, Pierre-Gregoire Coulon, +11 authors, Lbachir BenMohamed.
J Virol, 2019 Jun 21; 93(18). PMID: 31217250    Free PMC article.
Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease.
Soumyabrata Roy, Pierre-Grégoire Coulon, +7 authors, Lbachir BenMohamed.
Front Immunol, 2019 Jan 09; 9. PMID: 30619285    Free PMC article.
Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification.
Anne Monette, Derek Bergeron, +7 authors, Réjean Lapointe.
J Immunother Cancer, 2019 Mar 30; 7(1). PMID: 30922393    Free PMC article.
Cancer Nano-Immunotherapy from the Injection to the Target: The Role of Protein Corona.
Idoia Mikelez-Alonso, Antonio Aires, Aitziber L Cortajarena.
Int J Mol Sci, 2020 Jan 18; 21(2). PMID: 31947622    Free PMC article.
Review.
Armed oncolytic viruses: A kick-start for anti-tumor immunity.
J F de Graaf, L de Vor, R A M Fouchier, B G van den Hoogen.
Cytokine Growth Factor Rev, 2018 Mar 27; 41. PMID: 29576283    Free PMC article.
Highly Cited. Review.
Combining Oncolytic Viruses With Cancer Immunotherapy: Establishing a New Generation of Cancer Treatment.
Tao Shi, Xueru Song, +2 authors, Jia Wei.
Front Immunol, 2020 May 16; 11. PMID: 32411132    Free PMC article.
Review.
Combinatorial assessment of ctDNA release and mutational burden predicts anti-PD(L)1 therapy outcome in nonsmall-cell lung cancer.
Wenfeng Fang, Yuxiang Ma, +11 authors, Li Zhang.
Clin Transl Med, 2020 Jun 09; 10(1). PMID: 32508057    Free PMC article.
Biological Factors behind Melanoma Response to Immune Checkpoint Inhibitors.
Magdalena Olbryt, Marcin Rajczykowski, Wiesława Widłak.
Int J Mol Sci, 2020 Jun 11; 21(11). PMID: 32517213    Free PMC article.
Review.
Features associated with melanoma metastasis in Latvia.
Dace Pjanova, Dace Ruklisa, +3 authors, Ingrida Cema.
Oncol Lett, 2020 Aug 31; 20(4). PMID: 32863930    Free PMC article.
Balancing Cancer Immunotherapy Efficacy and Toxicity.
Douglas B Johnson, Baruch D Jakubovic, Vincent Sibaud, Meghan E Sise.
J Allergy Clin Immunol Pract, 2020 Jul 01; 8(9). PMID: 32599218    Free PMC article.
Review.
Progress of immune checkpoint LAG-3 in immunotherapy.
Chanchan Shan, Xing Li, Jian Zhang.
Oncol Lett, 2020 Sep 24; 20(5). PMID: 32963613    Free PMC article.
Review.
The promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy.
Long Long, Xue Zhang, +4 authors, Honglei Chen.
Genes Cancer, 2019 Jan 04; 9(5-6). PMID: 30603054    Free PMC article.
Highly Cited. Review.
Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System.
Shweta Joshi, Donald L Durden.
J Oncol, 2019 Mar 12; 2019. PMID: 30853982    Free PMC article.
Review.
Molecular background of skin melanoma development and progression: therapeutic implications.
Magdalena Olbryt.
Postepy Dermatol Alergol, 2019 Jul 20; 36(2). PMID: 31320844    Free PMC article.
Review.
Immune Checkpoint Receptors Tim-3 and PD-1 Regulate Monocyte and T Lymphocyte Function in Septic Patients.
Qi Xia, Li Wei, +3 authors, Yi Zhang.
Mediators Inflamm, 2019 Jan 01; 2018. PMID: 30595665    Free PMC article.
Enhanced Antitumor Immune Response in 2'-5' Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy.
Chan Kyu Sim, Jung Hoon Lee, +2 authors, Myeong Sup Lee.
J Immunol Res, 2019 May 03; 2019. PMID: 31049360    Free PMC article.
Targeted Delivery of CXCL9 and OX40L by Mesenchymal Stem Cells Elicits Potent Antitumor Immunity.
Pan Yin, Liming Gui, +6 authors, Wei-Qiang Gao.
Mol Ther, 2020 Aug 23; 28(12). PMID: 32827461    Free PMC article.
Magnesium in Combinatorial With Valproic Acid Suppressed the Proliferation and Migration of Human Bladder Cancer Cells.
Tianye Li, Yang Yu, +7 authors, Bing Wang.
Front Oncol, 2020 Dec 29; 10. PMID: 33363019    Free PMC article.
Endocrine toxicities of immune checkpoint inhibitors.
Jordan J Wright, Alvin C Powers, Douglas B Johnson.
Nat Rev Endocrinol, 2021 Apr 21; 17(7). PMID: 33875857    Free PMC article.
Review.
Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors.
Roman V Uzhachenko, Vijaya Bharti, +11 authors, Anna E Vilgelm.
Cell Rep, 2021 Apr 08; 35(1). PMID: 33826903    Free PMC article.
Immune-checkpoint inhibitors: long-term implications of toxicity.
Douglas B Johnson, Caroline A Nebhan, Javid J Moslehi, Justin M Balko.
Nat Rev Clin Oncol, 2022 Jan 28; 19(4). PMID: 35082367    Free PMC article.
Review.
CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism.
Juliane Medler, Kirstin Kucka, +7 authors, Harald Wajant.
Theranostics, 2022 Feb 25; 12(4). PMID: 35198053    Free PMC article.