Journal Article
. 2016 Aug;7().
doi: 10.1038/ncomms12474.

Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features

Kun-Hsing Yu 1 Ce Zhang 2 Gerald J Berry 3 Russ B Altman 1 Christopher Ré 2 Daniel L Rubin 1 Michael Snyder 4 
Affiliations
  • PMID: 27527408
  •     48 References
  •     174 citations

Abstract

Lung cancer is the most prevalent cancer worldwide, and histopathological assessment is indispensable for its diagnosis. However, human evaluation of pathology slides cannot accurately predict patients' prognoses. In this study, we obtain 2,186 haematoxylin and eosin stained histopathology whole-slide images of lung adenocarcinoma and squamous cell carcinoma patients from The Cancer Genome Atlas (TCGA), and 294 additional images from Stanford Tissue Microarray (TMA) Database. We extract 9,879 quantitative image features and use regularized machine-learning methods to select the top features and to distinguish shorter-term survivors from longer-term survivors with stage I adenocarcinoma (P<0.003) or squamous cell carcinoma (P=0.023) in the TCGA data set. We validate the survival prediction framework with the TMA cohort (P<0.036 for both tumour types). Our results suggest that automatically derived image features can predict the prognosis of lung cancer patients and thereby contribute to precision oncology. Our methods are extensible to histopathology images of other organs.

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Shidan Wang, Donghan M Yang, +7 authors, Guanghua Xiao.
Cancers (Basel), 2019 Oct 31; 11(11). PMID: 31661863    Free PMC article.
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Resolution-agnostic tissue segmentation in whole-slide histopathology images with convolutional neural networks.
Péter Bándi, Maschenka Balkenhol, +2 authors, Geert Litjens.
PeerJ, 2019 Dec 25; 7. PMID: 31871843    Free PMC article.
ConvPath: A software tool for lung adenocarcinoma digital pathological image analysis aided by a convolutional neural network.
Shidan Wang, Tao Wang, +15 authors, Guanghua Xiao.
EBioMedicine, 2019 Nov 27; 50. PMID: 31767541    Free PMC article.
Feasibility of fully automated classification of whole slide images based on deep learning.
Kyung-Ok Cho, Sung Hak Lee, Hyun-Jong Jang.
Korean J Physiol Pharmacol, 2020 Jan 08; 24(1). PMID: 31908578    Free PMC article.
Automated Gleason Scoring and Tumor Quantification in Prostate Core Needle Biopsy Images Using Deep Neural Networks and Its Comparison with Pathologist-Based Assessment.
Han Suk Ryu, Min-Sun Jin, +10 authors, Hyeyoon Chang.
Cancers (Basel), 2019 Nov 27; 11(12). PMID: 31769420    Free PMC article.
A deep learning image-based intrinsic molecular subtype classifier of breast tumors reveals tumor heterogeneity that may affect survival.
Mustafa I Jaber, Bing Song, +5 authors, Christopher W Szeto.
Breast Cancer Res, 2020 Jan 30; 22(1). PMID: 31992350    Free PMC article.
Fighting healthcare rocketing costs with value-based medicine: the case of stroke management.
Federico Esposti, Giuseppe Banfi.
BMC Health Serv Res, 2020 Feb 03; 20(1). PMID: 32007089    Free PMC article.
Deep Transfer Learning and Radiomics Feature Prediction of Survival of Patients with High-Grade Gliomas.
W Han, L Qin, +6 authors, G Young.
AJNR Am J Neuroradiol, 2019 Dec 21; 41(1). PMID: 31857325    Free PMC article.
Clinical implications of intratumor heterogeneity: challenges and opportunities.
Santiago Ramón Y Cajal, Marta Sesé, +5 authors, Josep Castellví.
J Mol Med (Berl), 2020 Jan 24; 98(2). PMID: 31970428    Free PMC article.
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Multi-objective Parameter Auto-tuning for Tissue Image Segmentation Workflows.
Luis F R Taveira, Tahsin Kurc, +4 authors, George Teodoro.
J Digit Imaging, 2018 Nov 08; 32(3). PMID: 30402669    Free PMC article.
Development and Validation of a Pathology Image Analysis-based Predictive Model for Lung Adenocarcinoma Prognosis - A Multi-cohort Study.
Xin Luo, Shen Yin, +11 authors, Guanghua Xiao.
Sci Rep, 2019 May 06; 9(1). PMID: 31053738    Free PMC article.
Pan-Renal Cell Carcinoma classification and survival prediction from histopathology images using deep learning.
Sairam Tabibu, P K Vinod, C V Jawahar.
Sci Rep, 2019 Jul 22; 9(1). PMID: 31324828    Free PMC article.
Increase Trichomonas vaginalis detection based on urine routine analysis through a machine learning approach.
Hsin-Yao Wang, Chung-Chih Hung, +8 authors, Jang-Jih Lu.
Sci Rep, 2019 Aug 20; 9(1). PMID: 31423009    Free PMC article.
Robust, independent and relevant prognostic 18F-fluorodeoxyglucose positron emission tomography radiomics features in non-small cell lung cancer: Are there any?
Tom Konert, Sarah Everitt, +5 authors, Jan-Jakob Sonke.
PLoS One, 2020 Feb 26; 15(2). PMID: 32097418    Free PMC article.
Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non-Small Cell Lung Cancer.
Germán Corredor, Xiangxue Wang, +9 authors, Anant Madabhushi.
Clin Cancer Res, 2018 Sep 12; 25(5). PMID: 30201760    Free PMC article.
An Interpretable and Expandable Deep Learning Diagnostic System for Multiple Ocular Diseases: Qualitative Study.
Kai Zhang, Xiyang Liu, +9 authors, Haotian Lin.
J Med Internet Res, 2018 Nov 16; 20(11). PMID: 30429111    Free PMC article.
Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks.
Jason W Wei, Laura J Tafe, +3 authors, Saeed Hassanpour.
Sci Rep, 2019 Mar 06; 9(1). PMID: 30833650    Free PMC article.
Highly Cited.
Nuclear shape, architecture and orientation features from H&E images are able to predict recurrence in node-negative gastric adenocarcinoma.
Meng-Yao Ji, Lei Yuan, +5 authors, Wei-Guo Dong.
J Transl Med, 2019 Mar 20; 17(1). PMID: 30885234    Free PMC article.
Physician Confidence in Artificial Intelligence: An Online Mobile Survey.
Songhee Oh, Jae Heon Kim, +3 authors, Soon Hyo Kwon.
J Med Internet Res, 2019 Mar 26; 21(3). PMID: 30907742    Free PMC article.
Prediction of premature all-cause mortality: A prospective general population cohort study comparing machine-learning and standard epidemiological approaches.
Stephen F Weng, Luis Vaz, Nadeem Qureshi, Joe Kai.
PLoS One, 2019 Mar 28; 14(3). PMID: 30917171    Free PMC article.
Viable and necrotic tumor assessment from whole slide images of osteosarcoma using machine-learning and deep-learning models.
Harish Babu Arunachalam, Rashika Mishra, +6 authors, Patrick Leavey.
PLoS One, 2019 Apr 18; 14(4). PMID: 30995247    Free PMC article.
Combining Diagnostic Imaging and Pathology for Improving Diagnosis and Prognosis of Cancer.
Orazio Schillaci, Manuel Scimeca, +3 authors, Elena Bonanno.
Contrast Media Mol Imaging, 2019 Jul 30; 2019. PMID: 31354394    Free PMC article.
Review.
A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk.
Sergey Klimov, Islam M Miligy, +8 authors, Ritu Aneja.
Breast Cancer Res, 2019 Jul 31; 21(1). PMID: 31358020    Free PMC article.
Segmentation and Classification in Digital Pathology for Glioma Research: Challenges and Deep Learning Approaches.
Tahsin Kurc, Spyridon Bakas, +21 authors, Keyvan Farahani.
Front Neurosci, 2020 Mar 11; 14. PMID: 32153349    Free PMC article.
Computational analysis of morphological and molecular features in gastric cancer tissues.
Yoko Yasuda, Kazuaki Tokunaga, +4 authors, Mitsuyoshi Nakao.
Cancer Med, 2020 Feb 06; 9(6). PMID: 32012497    Free PMC article.
Glandular orientation and shape determined by computational pathology could identify aggressive tumor for early colon carcinoma: a triple-center study.
Meng-Yao Ji, Lei Yuan, +8 authors, Wei-Guo Dong.
J Transl Med, 2020 Mar 18; 18(1). PMID: 32178690    Free PMC article.
Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine.
Zeeshan Ahmed, Khalid Mohamed, Saman Zeeshan, XinQi Dong.
Database (Oxford), 2020 Mar 19; 2020. PMID: 32185396    Free PMC article.
Deep learning pathological microscopic features in endemic nasopharyngeal cancer: Prognostic value and protentional role for individual induction chemotherapy.
Kuiyuan Liu, Weixiong Xia, +4 authors, Xing Lv.
Cancer Med, 2019 Dec 21; 9(4). PMID: 31860791    Free PMC article.
A deep learning-based framework for lung cancer survival analysis with biomarker interpretation.
Lei Cui, Hansheng Li, +5 authors, Jun Feng.
BMC Bioinformatics, 2020 Mar 19; 21(1). PMID: 32183709    Free PMC article.
LncRNA PLAC 2 downregulated miR-21 in non-small cell lung cancer and predicted survival.
Huan Xia, Ming Xiu, Jinying Gao, Hongyu Jing.
BMC Pulm Med, 2019 Sep 11; 19(1). PMID: 31500623    Free PMC article.
Histopathological Imaging⁻Environment Interactions in Cancer Modeling.
Yaqing Xu, Tingyan Zhong, Mengyun Wu, Shuangge Ma.
Cancers (Basel), 2019 Apr 27; 11(4). PMID: 31022926    Free PMC article.
Deep Learning Model as a New Trend in Computer-aided Diagnosis of Tumor Pathology for Lung Cancer.
Lei Cong, Wanbing Feng, +2 authors, Wei Xiao.
J Cancer, 2020 Apr 15; 11(12). PMID: 32284758    Free PMC article.
Review.
Computational analysis of pathological images enables a better diagnosis of TFE3 Xp11.2 translocation renal cell carcinoma.
Jun Cheng, Zhi Han, +7 authors, Jie Zhang.
Nat Commun, 2020 Apr 15; 11(1). PMID: 32286325    Free PMC article.
DeepSurvNet: deep survival convolutional network for brain cancer survival rate classification based on histopathological images.
Amin Zadeh Shirazi, Eric Fornaciari, +3 authors, Guillermo A Gomez.
Med Biol Eng Comput, 2020 Mar 04; 58(5). PMID: 32124225    Free PMC article.
Deep learned tissue "fingerprints" classify breast cancers by ER/PR/Her2 status from H&E images.
Rishi R Rawat, Itzel Ortega, +4 authors, David B Agus.
Sci Rep, 2020 May 01; 10(1). PMID: 32350370    Free PMC article.
Accurate diagnosis of lymphoma on whole-slide histopathology images using deep learning.
Charlotte Syrykh, Arnaud Abreu, +7 authors, Pierre Brousset.
NPJ Digit Med, 2020 May 08; 3. PMID: 32377574    Free PMC article.
Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis.
Miaomiao Gao, Weikaixin Kong, Zhuo Huang, Zhengwei Xie.
Int J Mol Sci, 2020 Apr 29; 21(8). PMID: 32340320    Free PMC article.
Integrative Analysis of Histopathological Images and Genomic Data Predicts Clear Cell Renal Cell Carcinoma Prognosis.
Jun Cheng, Jie Zhang, +7 authors, Kun Huang.
Cancer Res, 2017 Nov 03; 77(21). PMID: 29092949    Free PMC article.
Radiomics of Multiparametric MRI to Predict Biochemical Recurrence of Localized Prostate Cancer After Radiation Therapy.
Qiu-Zi Zhong, Liu-Hua Long, +13 authors, Gao-Feng Li.
Front Oncol, 2020 Jun 02; 10. PMID: 32477949    Free PMC article.
Automated quantitative analysis of Ki-67 staining and HE images recognition and registration based on whole tissue sections in breast carcinoma.
Min Feng, Yang Deng, +10 authors, Hong Bu.
Diagn Pathol, 2020 May 31; 15(1). PMID: 32471471    Free PMC article.
Role of artificial intelligence in diagnostic oral pathology-A modern approach.
Ayinampudi Bhargavi Krishna, Azra Tanveer, Pancha Venkat Bhagirath, Ashalata Gannepalli.
J Oral Maxillofac Pathol, 2020 Jun 09; 24(1). PMID: 32508465    Free PMC article.
miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein.
Yanan Zhao, Xiaosong Sun, Kun Zhu, Min Cheng.
Biosci Rep, 2020 Jun 03; 40(6). PMID: 32484204    Free PMC article.
Improving Classification of Breast Cancer by Utilizing the Image Pyramids of Whole-Slide Imaging and Multi-Scale Convolutional Neural Networks.
Li Tong, Ying Sha, May D Wang.
Proc COMPSAC, 2020 Jun 20; 2019. PMID: 32558827    Free PMC article.
Deep learning-based survival prediction for multiple cancer types using histopathology images.
Ellery Wulczyn, David F Steiner, +7 authors, Martin C Stumpe.
PLoS One, 2020 Jun 20; 15(6). PMID: 32555646    Free PMC article.
Classifying non-small cell lung cancer types and transcriptomic subtypes using convolutional neural networks.
Kun-Hsing Yu, Feiran Wang, +4 authors, Isaac S Kohane.
J Am Med Inform Assoc, 2020 May 05; 27(5). PMID: 32364237    Free PMC article.
A population health perspective on artificial intelligence.
Maxime Lavigne, Fatima Mussa, +2 authors, David L Buckeridge.
Healthc Manage Forum, 2019 May 21; 32(4). PMID: 31106580    Free PMC article.
Sensitivity analysis in digital pathology: Handling large number of parameters with compute expensive workflows.
Jeremias Gomes, Willian Barreiros, +4 authors, George Teodoro.
Comput Biol Med, 2019 May 06; 108. PMID: 31054503    Free PMC article.
Histopathological distinction of non-invasive and invasive bladder cancers using machine learning approaches.
Peng-Nien Yin, Kishan Kc, +5 authors, Feng Cui.
BMC Med Inform Decis Mak, 2020 Jul 19; 20(1). PMID: 32680493    Free PMC article.
Proceedings of the fourth international molecular pathological epidemiology (MPE) meeting.
Peter T Campbell, Christine B Ambrosone, +27 authors, Shuji Ogino.
Cancer Causes Control, 2019 May 10; 30(8). PMID: 31069578    Free PMC article.
Requirements of Health Data Management Systems for Biomedical Care and Research: Scoping Review.
Leila Ismail, Huned Materwala, Achim P Karduck, Abdu Adem.
J Med Internet Res, 2020 Apr 30; 22(7). PMID: 32348265    Free PMC article.
Review.
Predicting treatment response to neoadjuvant chemoradiotherapy in local advanced rectal cancer by biopsy digital pathology image features.
Fang Zhang, Su Yao, +7 authors, Zaiyi Liu.
Clin Transl Med, 2020 Jul 01; 10(2). PMID: 32594660    Free PMC article.
Cross-Modal Data Programming Enables Rapid Medical Machine Learning.
Jared A Dunnmon, Alexander J Ratner, +8 authors, Christopher Ré.
Patterns (N Y), 2020 Aug 11; 1(2). PMID: 32776018    Free PMC article.
Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks.
Kun-Hsing Yu, Vincent Hu, +4 authors, Isaac S Kohane.
BMC Med, 2020 Aug 19; 18(1). PMID: 32807164    Free PMC article.
p28 Bacterial Peptide, as an Anticancer Agent.
Atieh Yaghoubi, Majid Khazaei, +3 authors, Saman Soleimanpour.
Front Oncol, 2020 Aug 28; 10. PMID: 32850408    Free PMC article.
Review.
Reproducible Machine Learning Methods for Lung Cancer Detection Using Computed Tomography Images: Algorithm Development and Validation.
Kun-Hsing Yu, Tsung-Lu Michael Lee, +4 authors, Isaac S Kohane.
J Med Internet Res, 2020 Aug 07; 22(8). PMID: 32755895    Free PMC article.
Artificial Intelligence to Decode Cancer Mechanism: Beyond Patient Stratification for Precision Oncology.
Sandip Kumar Patel, Bhawana George, Vineeta Rai.
Front Pharmacol, 2020 Sep 10; 11. PMID: 32903628    Free PMC article.
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Artificial Intelligence in Pathology.
Hye Yoon Chang, Chan Kwon Jung, +4 authors, Tae-Yeong Kwak.
J Pathol Transl Med, 2019 Jan 03; 53(1). PMID: 30599506    Free PMC article.
Highly Cited.
Twenty Years of Digital Pathology: An Overview of the Road Travelled, What is on the Horizon, and the Emergence of Vendor-Neutral Archives.
Liron Pantanowitz, Ashish Sharma, +3 authors, Joel Saltz.
J Pathol Inform, 2019 Jan 05; 9. PMID: 30607307    Free PMC article.
Review.
Dual-Model Radiomic Biomarkers Predict Development of Mild Cognitive Impairment Progression to Alzheimer's Disease.
Hucheng Zhou, Jiehui Jiang, +4 authors, Alzheimer’s Disease Neuroimaging Initiative.
Front Neurosci, 2019 Jan 29; 12. PMID: 30686995    Free PMC article.
Recurrence analysis on prostate cancer patients with Gleason score 7 using integrated histopathology whole-slide images and genomic data through deep neural networks.
Jian Ren, Kubra Karagoz, +4 authors, Xin Qi.
J Med Imaging (Bellingham), 2019 Mar 07; 5(4). PMID: 30840742    Free PMC article.
Examination of Independent Prognostic Power of Gene Expressions and Histopathological Imaging Features in Cancer.
Tingyan Zhong, Mengyun Wu, Shuangge Ma.
Cancers (Basel), 2019 Mar 16; 11(3). PMID: 30871256    Free PMC article.
Automated segmentation of dermal fillers in OCT images of mice using convolutional neural networks.
Martin Pfister, Kornelia Schützenberger, +8 authors, René M Werkmeister.
Biomed Opt Express, 2019 Mar 21; 10(3). PMID: 30891348    Free PMC article.
The promise and challenges of deep learning models for automated histopathologic classification and mutation prediction in lung cancer.
Pradnya D Patil, Brian Hobbs, Nathan A Pennell.
J Thorac Dis, 2019 Apr 10; 11(2). PMID: 30962976    Free PMC article.
Methods for Segmentation and Classification of Digital Microscopy Tissue Images.
Quoc Dang Vu, Simon Graham, +12 authors, Keyvan Farahani.
Front Bioeng Biotechnol, 2019 Apr 20; 7. PMID: 31001524    Free PMC article.
Molecular and Morphological Profiling of Lung Cancer: A Foundation for "Next-Generation" Pathologists and Oncologists.
Jumpei Kashima, Rui Kitadai, Yusuke Okuma.
Cancers (Basel), 2019 May 01; 11(5). PMID: 31035693    Free PMC article.
Review.
An Ensemble Strategy to Predict Prognosis in Ovarian Cancer Based on Gene Modules.
Yi-Cheng Gao, Xiong-Hui Zhou, Wen Zhang.
Front Genet, 2019 May 10; 10. PMID: 31068972    Free PMC article.
A two-pronged progress in structured dense matrixvector multiplication.
Christopher De Sa, Albert Gu, +2 authors, Atri Rudra.
Proc Annu ACM SIAM Symp Discret Algorithms, 2018 Jan 01; 2018. PMID: 31130802    Free PMC article.
KekuleScope: prediction of cancer cell line sensitivity and compound potency using convolutional neural networks trained on compound images.
Isidro Cortés-Ciriano, Andreas Bender.
J Cheminform, 2019 Jun 21; 11(1). PMID: 31218493    Free PMC article.
Deep Learning: A Rapid and Efficient Route to Automatic Metasurface Design.
Tianshuo Qiu, Xin Shi, +5 authors, Sai Sui.
Adv Sci (Weinh), 2019 Aug 06; 6(12). PMID: 31380164    Free PMC article.
The Promise of Digital Biopsy for the Prediction of Tumor Molecular Features and Clinical Outcomes Associated With Immunotherapy.
Giuseppe Luigi Banna, Timothée Olivier, +4 authors, Alfredo Addeo.
Front Med (Lausanne), 2019 Aug 17; 6. PMID: 31417906    Free PMC article.
Predicting prognosis of endometrioid endometrial adenocarcinoma on the basis of gene expression and clinical features using Random Forest.
Fufen Yin, Xingyang Shao, +7 authors, Jianliu Wang.
Oncol Lett, 2019 Aug 20; 18(2). PMID: 31423227    Free PMC article.
A Proposal to Reflect Survival Difference and Modify the Staging System for Lung Adenocarcinoma and Squamous Cell Carcinoma: Based on the Machine Learning.
Ming Li, Cheng Zhan, +6 authors, Qun Wang.
Front Oncol, 2019 Sep 03; 9. PMID: 31475114    Free PMC article.
Innovative approaches for cancer treatment: current perspectives and new challenges.
Carlotta Pucci, Chiara Martinelli, Gianni Ciofani.
Ecancermedicalscience, 2019 Sep 21; 13. PMID: 31537986    Free PMC article.
Multiparametric MRI and Whole Slide Image-Based Pretreatment Prediction of Pathological Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer: A Multicenter Radiopathomic Study.
Lizhi Shao, Zhenyu Liu, +13 authors, Jie Tian.
Ann Surg Oncol, 2020 Jul 31; 27(11). PMID: 32729045    Free PMC article.
BIAS: Transparent reporting of biomedical image analysis challenges.
Lena Maier-Hein, Annika Reinke, +11 authors, Bennett A Landman.
Med Image Anal, 2020 Sep 11; 66. PMID: 32911207    Free PMC article.
Histopathological imaging features- versus molecular measurements-based cancer prognosis modeling.
Sanguo Zhang, Yu Fan, Tingyan Zhong, Shuangge Ma.
Sci Rep, 2020 Sep 16; 10(1). PMID: 32929170    Free PMC article.
Unsupervised Resolution of Histomorphologic Heterogeneity in Renal Cell Carcinoma Using a Brain Tumor-Educated Neural Network.
Kevin Faust, Adil Roohi, +7 authors, Phedias Diamandis.
JCO Clin Cancer Inform, 2020 Sep 19; 4. PMID: 32946287    Free PMC article.
Acute myeloid leukemia and artificial intelligence, algorithms and new scores.
Nathan Radakovich, Matthew Cortese, Aziz Nazha.
Best Pract Res Clin Haematol, 2020 Oct 12; 33(3). PMID: 33038981    Free PMC article.
Review.
LibMI: An Open Source Library for Efficient Histopathological Image Processing.
Yuxin Dong, Pargorn Puttapirat, +2 authors, Chen Li.
J Pathol Inform, 2020 Oct 13; 11. PMID: 33042605    Free PMC article.
Clinical Trials for Artificial Intelligence in Cancer Diagnosis: A Cross-Sectional Study of Registered Trials in ClinicalTrials.gov.
Jingsi Dong, Yingcai Geng, +4 authors, Yonggang Zhang.
Front Oncol, 2020 Oct 13; 10. PMID: 33042806    Free PMC article.
Driverless artificial intelligence framework for the identification of malignant pleural effusion.
Yuan Li, Shan Tian, Yajun Huang, Weiguo Dong.
Transl Oncol, 2020 Oct 13; 14(1). PMID: 33045678    Free PMC article.
Spatial transcriptomics inferred from pathology whole-slide images links tumor heterogeneity to survival in breast and lung cancer.
Alona Levy-Jurgenson, Xavier Tekpli, Vessela N Kristensen, Zohar Yakhini.
Sci Rep, 2020 Nov 04; 10(1). PMID: 33139755    Free PMC article.
A prognostic model for overall survival of patients with early-stage non-small cell lung cancer: a multicentre, retrospective study.
Cheng Lu, Kaustav Bera, +14 authors, Anant Madabhushi.
Lancet Digit Health, 2020 Nov 10; 2(11). PMID: 33163952    Free PMC article.
Artificial intelligence quantified tumour-stroma ratio is an independent predictor for overall survival in resectable colorectal cancer.
Ke Zhao, Zhenhui Li, +7 authors, Zaiyi Liu.
EBioMedicine, 2020 Oct 12; 61. PMID: 33039706    Free PMC article.
DeepLRHE: A Deep Convolutional Neural Network Framework to Evaluate the Risk of Lung Cancer Recurrence and Metastasis From Histopathology Images.
Zhijun Wu, Lin Wang, +6 authors, Yonggang Liu.
Front Genet, 2020 Nov 17; 11. PMID: 33193560    Free PMC article.
Hist-Immune signature: a prognostic factor in colorectal cancer using immunohistochemical slide image analysis.
Ke Zhao, Zhenhui Li, +8 authors, Zaiyi Liu.
Oncoimmunology, 2020 Nov 17; 9(1). PMID: 33194320    Free PMC article.
Integrative Models of Histopathological Image Features and Omics Data Predict Survival in Head and Neck Squamous Cell Carcinoma.
Hao Zeng, Linyan Chen, +2 authors, Xuelei Ma.
Front Cell Dev Biol, 2020 Nov 17; 8. PMID: 33195188    Free PMC article.
A narrative review of digital pathology and artificial intelligence: focusing on lung cancer.
Taro Sakamoto, Tomoi Furukawa, +8 authors, Junya Fukuoka.
Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209648    Free PMC article.
Review.
Application of machine learning in rheumatic disease research.
Ki-Jo Kim, Ilias Tagkopoulos.
Korean J Intern Med, 2019 Jan 09; 34(4). PMID: 30616329    Free PMC article.
Review.
Accuracy Enhanced Lung Cancer Prognosis for Improving Patient Survivability Using Proposed Gaussian Classifier System.
Kaviarasi R, Gandhi Raj R.
J Med Syst, 2019 May 28; 43(7). PMID: 31127444
A systems approach to clinical oncology uses deep phenotyping to deliver personalized care.
James T Yurkovich, Qiang Tian, Nathan D Price, Leroy Hood.
Nat Rev Clin Oncol, 2019 Oct 18; 17(3). PMID: 31619755
Review.
Identification of toxic mold species through Raman spectroscopy of fungal conidia.
Benjamin D Strycker, Zehua Han, +5 authors, Marlan O Scully.
PLoS One, 2020 Nov 24; 15(11). PMID: 33227000    Free PMC article.
Identifying transcriptomic correlates of histology using deep learning.
Liviu Badea, Emil Stănescu.
PLoS One, 2020 Nov 26; 15(11). PMID: 33237966    Free PMC article.
Deep learning-based cross-classifications reveal conserved spatial behaviors within tumor histological images.
Javad Noorbakhsh, Saman Farahmand, +6 authors, Jeffrey H Chuang.
Nat Commun, 2020 Dec 15; 11(1). PMID: 33311458    Free PMC article.
Automatic model for cervical cancer screening based on convolutional neural network: a retrospective, multicohort, multicenter study.
Xiangyu Tan, Kexin Li, +5 authors, Xiaoyuan Huang.
Cancer Cell Int, 2021 Jan 09; 21(1). PMID: 33413391    Free PMC article.
Developing a new radiomics-based CT image marker to detect lymph node metastasis among cervical cancer patients.
Xuxin Chen, Wei Liu, +7 authors, Yuchen Qiu.
Comput Methods Programs Biomed, 2020 Oct 03; 197. PMID: 33007594    Free PMC article.
Long-Term Survival of Patients with Metastatic Non-Small-Cell Lung Cancer over Five Decades.
Jair Bar, Damien Urban, +6 authors, Yaacov Lawrence.
J Oncol, 2021 Feb 02; 2021. PMID: 33519934    Free PMC article.
Artificial intelligence neuropathologist for glioma classification using deep learning on hematoxylin and eosin stained slide images and molecular markers.
Lei Jin, Feng Shi, +10 authors, Jinsong Wu.
Neuro Oncol, 2020 Jul 15; 23(1). PMID: 32663285    Free PMC article.
Feature-driven local cell graph (FLocK): New computational pathology-based descriptors for prognosis of lung cancer and HPV status of oropharyngeal cancers.
Cheng Lu, Can Koyuncu, +8 authors, Anant Madabhushi.
Med Image Anal, 2020 Dec 23; 68. PMID: 33352373    Free PMC article.
Use of radiomics based on 18F-FDG PET/CT and machine learning methods to aid clinical decision-making in the classification of solitary pulmonary lesions: an innovative approach.
Yi Zhou, Xue-Lei Ma, +3 authors, Rong Tian.
Eur J Nucl Med Mol Imaging, 2021 Feb 07;. PMID: 33547553
A Novel Prognostic Scoring System of Intrahepatic Cholangiocarcinoma With Machine Learning Basing on Real-World Data.
Zhizhen Li, Lei Yuan, +6 authors, Xiaoqing Jiang.
Front Oncol, 2021 Feb 09; 10. PMID: 33552957    Free PMC article.
Deep Learning Image Analysis of Benign Breast Disease to Identify Subsequent Risk of Breast Cancer.
Adithya D Vellal, Korsuk Sirinukunwattan, +10 authors, Yujing J Heng.
JNCI Cancer Spectr, 2021 Mar 02; 5(1). PMID: 33644680    Free PMC article.
The Biological Meaning of Radiomic Features.
Michal R Tomaszewski, Robert J Gillies.
Radiology, 2021 Jan 06; 298(3). PMID: 33399513    Free PMC article.
Medical Image Classification Algorithm Based on Visual Attention Mechanism-MCNN.
Fengping An, Xiaowei Li, Xingmin Ma.
Oxid Med Cell Longev, 2021 Mar 11; 2021. PMID: 33688390    Free PMC article.
Human-interpretable image features derived from densely mapped cancer pathology slides predict diverse molecular phenotypes.
James A Diao, Jason K Wang, +19 authors, Amaro Taylor-Weiner.
Nat Commun, 2021 Mar 14; 12(1). PMID: 33712588    Free PMC article.
Artificial intelligence (AI) in medicine, current applications and future role with special emphasis on its potential and promise in pathology: present and future impact, obstacles including costs and acceptance among pathologists, practical and philosophical considerations. A comprehensive review.
Zubair Ahmad, Shabina Rahim, Maha Zubair, Jamshid Abdul-Ghafar.
Diagn Pathol, 2021 Mar 19; 16(1). PMID: 33731170    Free PMC article.
Review.
Predicting gastric cancer outcome from resected lymph node histopathology images using deep learning.
Xiaodong Wang, Ying Chen, +15 authors, Guanzhen Yu.
Nat Commun, 2021 Mar 14; 12(1). PMID: 33712598    Free PMC article.
Two-stage Cox-nnet: biologically interpretable neural-network model for prognosis prediction and its application in liver cancer survival using histopathology and transcriptomic data.
Zhucheng Zhan, Zheng Jing, +4 authors, Lana X Garmire.
NAR Genom Bioinform, 2021 Mar 30; 3(1). PMID: 33778491    Free PMC article.
Decoding and Systematization of Medical Imaging Features of Multiple Human Malignancies.
Lu Wang, Zhaoyu Liu, +8 authors, Jiangdian Song.
Radiol Imaging Cancer, 2021 Mar 30; 2(5). PMID: 33778732    Free PMC article.
A deep learning model for the classification of indeterminate lung carcinoma in biopsy whole slide images.
Fahdi Kanavati, Gouji Toyokawa, +6 authors, Masayuki Tsuneki.
Sci Rep, 2021 Apr 16; 11(1). PMID: 33854137    Free PMC article.
Interpretable survival prediction for colorectal cancer using deep learning.
Ellery Wulczyn, David F Steiner, +20 authors, Craig H Mermel.
NPJ Digit Med, 2021 Apr 21; 4(1). PMID: 33875798