Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy

Kazuhide Sato ¹, Noriko Sato ², Biying Xu ³, Yuko Nakamura ², Tadanobu Nagaya ², Peter L Choyke ², Yoshinori Hasegawa ⁴, Hisataka Kobayashi ⁵

Affiliations

¹ Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1002, USA. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
² Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1002, USA.
³ Image Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-3372, USA.
⁴ Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
⁵ Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1002, USA. kobayash@mail.nih.gov.

PMID: 27535621
43 References
69 citations

Abstract

Current immunotherapies for cancer seek to modulate the balance among different immune cell populations, thereby promoting antitumor immune responses. However, because these are systemic therapies, they often cause treatment-limiting autoimmune adverse effects. It would be ideal to manipulate the balance between suppressor and effector cells within the tumor without disturbing homeostasis elsewhere in the body. CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are well-known immunosuppressor cells that play a key role in tumor immunoevasion and have been the target of systemic immunotherapies. We used CD25-targeted near-infrared photoimmunotherapy (NIR-PIT) to selectively deplete Tregs, thus activating CD8 T and natural killer cells and restoring local antitumor immunity. This not only resulted in regression of the treated tumor but also induced responses in separate untreated tumors of the same cell line derivation. We conclude that CD25-targeted NIR-PIT causes spatially selective depletion of Tregs, thereby providing an alternative approach to cancer immunotherapy.

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References
Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion. Michele W L Teng, Jeremy B Swann, +7 authors, Mark J Smyth. less Cancer Res, 2010 Mar 25; 70(7). PMID: 20332236
Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens. Richard W Childs, Mattias Carlsten. Nat Rev Drug Discov, 2015 May 23; 14(7). PMID: 26000725 Highly Cited. Review.
Evolving synergistic combinations of targeted immunotherapies to combat cancer. Ignacio Melero, David M Berman, +3 authors, John Haanen. less Nat Rev Cancer, 2015 Jul 25; 15(8). PMID: 26205340 Highly Cited. Review.
Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor. Kazuhide Sato, Rira Watanabe, +6 authors, Hisataka Kobayashi. less Mol Oncol, 2014 Feb 11; 8(3). PMID: 24508062 Free PMC article.
Adoptive cellular therapy: a race to the finish line. Carl H June, Stanley R Riddell, Ton N Schumacher. Sci Transl Med, 2015 Mar 27; 7(280). PMID: 25810311 Highly Cited. Review.
Deciphering and reversing tumor immune suppression. Greg T Motz, George Coukos. Immunity, 2013 Jul 31; 39(1). PMID: 23890064 Free PMC article. Highly Cited. Review.
Anti-PD-1-Related Pneumonitis during Cancer Immunotherapy. Mizuki Nishino, Lynette M Sholl, +2 authors, F Stephen Hodi, Hiroto Hatabu, Nikhil H Ramaiya. less N Engl J Med, 2015 Jul 16; 373(3). PMID: 26176400 Free PMC article. Highly Cited.
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. S Onizuka, I Tawara, +3 authors, J Shimizu, S Sakaguchi, T Fujita, E Nakayama. less Cancer Res, 1999 Jul 09; 59(13). PMID: 10397255 Highly Cited.
CD103 is a hallmark of tumor-infiltrating regulatory T cells. David Anz, Wolfgang Mueller, +8 authors, Stefan Endres. less Int J Cancer, 2011 Jan 06; 129(10). PMID: 21207371
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. Paula D Bos, George Plitas, +2 authors, Dipayan Rudra, Sue Y Lee, Alexander Y Rudensky. less J Exp Med, 2013 Oct 16; 210(11). PMID: 24127486 Free PMC article. Highly Cited.
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. S Sakaguchi, N Sakaguchi, +2 authors, M Asano, M Itoh, M Toda. less J Immunol, 1995 Aug 01; 155(3). PMID: 7636184 Highly Cited.
Near infrared photoimmunotherapy prevents lung cancer metastases in a murine model. Kazuhide Sato, Tadanobu Nagaya, +3 authors, Hisataka Kobayashi. less Oncotarget, 2015 May 21; 6(23). PMID: 25992770 Free PMC article.
The future of immune checkpoint therapy. Padmanee Sharma, James P Allison. Science, 2015 Apr 04; 348(6230). PMID: 25838373 Highly Cited. Review.
Immune checkpoint blockade: a common denominator approach to cancer therapy. Suzanne L Topalian, Charles G Drake, Drew M Pardoll. Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804 Free PMC article. Highly Cited. Review.
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. Ganesh Suntharalingam, Meghan R Perry, +4 authors, Nicki Panoskaltsis. less N Engl J Med, 2006 Aug 16; 355(10). PMID: 16908486 Highly Cited.
Effector/memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity. Yung-Chang Lin, Li-Yuan Chang, +5 authors, Chun-Yen Lin. less J Immunol, 2009 May 06; 182(10). PMID: 19414761
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. Kuibeom Ko, Sayuri Yamazaki, +7 authors, Shimon Sakaguchi. less J Exp Med, 2005 Sep 28; 202(7). PMID: 16186187 Free PMC article. Highly Cited.
Cytokine release in patients with CLL treated with obinutuzumab and possible relationship with infusion-related reactions. Ciara L Freeman, Franck Morschhauser, +9 authors, Guillaume Cartron. less Blood, 2015 Oct 09; 126(24). PMID: 26447188 Free PMC article.
Near infrared photoimmunotherapy for lung metastases. Kazuhide Sato, Tadanobu Nagaya, +2 authors, Makoto Mitsunaga, Peter L Choyke, Hisataka Kobayashi. less Cancer Lett, 2015 May 30; 365(1). PMID: 26021765 Free PMC article.
T-regulatory cells: key players in tumor immune escape and angiogenesis. Andrea Facciabene, Gregory T Motz, George Coukos. Cancer Res, 2012 May 03; 72(9). PMID: 22549946 Free PMC article. Highly Cited. Review.
IL-6 in inflammation, immunity, and disease. Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto. Cold Spring Harb Perspect Biol, 2014 Sep 06; 6(10). PMID: 25190079 Free PMC article. Highly Cited. Review.
Immune-related adverse events with immune checkpoint blockade: a comprehensive review. J M Michot, C Bigenwald, +21 authors, O Lambotte. less Eur J Cancer, 2016 Jan 15; 54. PMID: 26765102 Highly Cited. Review.
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Laurence Zitvogel, Lorenzo Galluzzi, Mark J Smyth, Guido Kroemer. Immunity, 2013 Jul 31; 39(1). PMID: 23890065 Highly Cited. Review.
Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy. Mario P Colombo, Silvia Piconese. Nat Rev Cancer, 2007 Oct 25; 7(11). PMID: 17957190 Highly Cited. Review.
FOXP3+ regulatory T cells in the human immune system. Shimon Sakaguchi, Makoto Miyara, Cristina M Costantino, David A Hafler. Nat Rev Immunol, 2010 Jun 19; 10(7). PMID: 20559327 Highly Cited. Review.
Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma. Peter Attia, Ajay V Maker, +2 authors, Leah R Haworth, Linda Rogers-Freezer, Steven A Rosenberg. less J Immunother, 2005 Oct 15; 28(6). PMID: 16224276 Free PMC article.
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Makoto Mitsunaga, Mikako Ogawa, +3 authors, Hisataka Kobayashi. less Nat Med, 2011 Nov 08; 17(12). PMID: 22057348 Free PMC article. Highly Cited.
Potent and specific antitumor effect of CEA-targeted photoimmunotherapy. Naoto Shirasu, Hiromi Yamada, +2 authors, Hirotomo Shibaguchi, Motomu Kuroki, Masahide Kuroki. less Int J Cancer, 2014 Apr 18; 135(11). PMID: 24740257
Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. Ping Yu, Youjin Lee, +4 authors, Yang-Xin Fu. less J Exp Med, 2005 Mar 09; 201(5). PMID: 15753211 Free PMC article. Highly Cited.
Combination cancer immunotherapies tailored to the tumour microenvironment. Mark J Smyth, Shin Foong Ngiow, Antoni Ribas, Michele W L Teng. Nat Rev Clin Oncol, 2015 Nov 26; 13(3). PMID: 26598942 Highly Cited. Review.
Immunoengineering: how nanotechnology can enhance cancer immunotherapy. Michael S Goldberg. Cell, 2015 Apr 11; 161(2). PMID: 25860604 Review.
Efficient Treg depletion induces T-cell infiltration and rejection of large tumors. Xingrui Li, Efterpi Kostareli, +2 authors, Janine Suffner, Natalio Garbi, Günter J Hämmerling. less Eur J Immunol, 2010 Nov 13; 40(12). PMID: 21072887
Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovarian cancer. Kazuhide Sato, Hirofumi Hanaoka, +3 authors, Hisataka Kobayashi. less Mol Cancer Ther, 2014 Nov 25; 14(1). PMID: 25416790 Free PMC article.
Combination cancer immunotherapy and new immunomodulatory targets. Kathleen M Mahoney, Paul D Rennert, Gordon J Freeman. Nat Rev Drug Discov, 2015 Aug 01; 14(8). PMID: 26228759 Highly Cited. Review.
Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine. Kazuhide Sato, Takahito Nakajima, Peter L Choyke, Hisataka Kobayashi. RSC Adv, 2015 Apr 14; 5(32). PMID: 25866624 Free PMC article.
Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. Kevin N Couper, Daniel G Blount, +3 authors, Eleanor M Riley. less J Immunol, 2007 Mar 21; 178(7). PMID: 17371969 Free PMC article.
Regulatory T cells in cancer immunotherapy. Hiroyoshi Nishikawa, Shimon Sakaguchi. Curr Opin Immunol, 2014 Jan 15; 27. PMID: 24413387 Highly Cited. Review.
On being less tolerant: enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation. Alexander M Lesokhin, Margaret K Callahan, Michael A Postow, Jedd D Wolchok. Sci Transl Med, 2015 Mar 27; 7(280). PMID: 25810313 Highly Cited. Review.
Regulatory T cells, tumour immunity and immunotherapy. Weiping Zou. Nat Rev Immunol, 2006 Mar 25; 6(4). PMID: 16557261 Highly Cited. Review.
Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira Mellman. Immunity, 2013 Jul 31; 39(1). PMID: 23890059 Highly Cited. Review.
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Daisuke Sugiyama, Hiroyoshi Nishikawa, +10 authors, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2013 Oct 16; 110(44). PMID: 24127572 Free PMC article. Highly Cited.
Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Michele W L Teng, Shin Foong Ngiow, +3 authors, Mark J Smyth. less Cancer Res, 2010 Oct 07; 70(20). PMID: 20924111
The journey from discoveries in fundamental immunology to cancer immunotherapy. Jacques F A P Miller, Michel Sadelain. Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858803 Highly Cited. Review.

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Cancer: Tumour-specific ablation of Treg cells induces anticancer response. Alexandra Flemming. Nat Rev Drug Discov, 2016 Sep 30; 15(10). PMID: 27681792
Selective intracellular vaporisation of antibody-conjugated phase-change nano-droplets in vitro. A Ishijima, K Minamihata, +8 authors, I Sakuma. less Sci Rep, 2017 Mar 24; 7. PMID: 28333127 Free PMC article.
Cerenkov Radiation-Induced Photoimmunotherapy with 18F-FDG. Yuko Nakamura, Tadanobu Nagaya, +6 authors, Hisataka Kobayashi. less J Nucl Med, 2017 Apr 15; 58(9). PMID: 28408528 Free PMC article.
Near-infrared photoimmunotherapy: a comparison of light dosing schedules. Fusa Ogata, Tadanobu Nagaya, +5 authors, Hisataka Kobayashi. less Oncotarget, 2017 May 01; 8(21). PMID: 28456784 Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses. Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee. less Oncotarget, 2017 May 26; 8(29). PMID: 28537894 Free PMC article.
Delivering safer immunotherapies for cancer. Lauren Milling, Yuan Zhang, Darrell J Irvine. Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888 Free PMC article. Highly Cited. Review.
Near-Infrared Photoimmunotherapy Targeting Prostate Cancer with Prostate-Specific Membrane Antigen (PSMA) Antibody. Tadanobu Nagaya, Yuko Nakamura, +4 authors, Hisataka Kobayashi. less Mol Cancer Res, 2017 Jun 08; 15(9). PMID: 28588059 Free PMC article.
Syngeneic Mouse Models of Oral Cancer Are Effectively Targeted by Anti-CD44-Based NIR-PIT. Tadanobu Nagaya, Yuko Nakamura, +5 authors, Hisataka Kobayashi. less Mol Cancer Res, 2017 Sep 20; 15(12). PMID: 28923838 Free PMC article.
Photoacoustic stimulation promotes the osteogenic differentiation of bone mesenchymal stem cells to enhance the repair of bone defect. Zebin Huang, Jiankun Xu, +7 authors, Jun Hu. less Sci Rep, 2017 Nov 22; 7(1). PMID: 29158525 Free PMC article.
Dynamic changes in the cell membrane on three dimensional low coherent quantitative phase microscopy (3D LC-QPM) after treatment with the near infrared photoimmunotherapy. Fusa Ogata, Tadanobu Nagaya, +4 authors, Hisataka Kobayashi. less Oncotarget, 2017 Dec 22; 8(61). PMID: 29262641 Free PMC article.
Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes. Shun Kishimoto, Nobu Oshima, +5 authors, Murali C Krishna. less Free Radic Biol Med, 2018 Jan 01; 116. PMID: 29289705 Free PMC article.
3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo. Qinggong Tang, Tadanobu Nagaya, +5 authors, Yu Chen. less J Control Release, 2018 Apr 21; 279. PMID: 29673644 Free PMC article.
Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment in vivo. Yuya Isoda, Wen Piao, +9 authors, Kazuhiro Masuda. less Oncotarget, 2018 Aug 25; 9(59). PMID: 30140380 Free PMC article.
P-glycoprotein targeted photodynamic therapy of chemoresistant tumors using recombinant Fab fragment conjugates. Chengqiong Mao, Ping Qu, +3 authors, Michael J Miley, Yan Zhao, Zibo Li, Xin Ming. less Biomater Sci, 2018 Oct 10; 6(11). PMID: 30298866 Free PMC article.
Combining Heavy-Ion Therapy with Immunotherapy: An Update on Recent Developments. Alexander Helm, Daniel K Ebner, +6 authors, Takashi Shimokawa. less Int J Part Ther, 2018 Jul 01; 5(1). PMID: 31773022 Free PMC article. Review.
Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies. Naoto Shirasu, Hirotomo Shibaguchi, +2 authors, Hiromi Yamada, Masahide Kuroki, Shin'ichiro Yasunaga. less Cancer Cell Int, 2019 Dec 04; 19. PMID: 31787847 Free PMC article.
Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer. Yoshitaka Isobe, Kazuhide Sato, +14 authors, Yoshinori Hasegawa. less EBioMedicine, 2020 Jan 26; 52. PMID: 31981983 Free PMC article.
Near-Infrared Photoimmunotherapy of Cancer. Hisataka Kobayashi, Peter L Choyke. Acc Chem Res, 2019 Jul 25; 52(8). PMID: 31335117 Free PMC article. Highly Cited. Review.
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity. Masanori Onda, Kazuto Kobayashi, Ira Pastan. Proc Natl Acad Sci U S A, 2019 Feb 15; 116(10). PMID: 30760587 Free PMC article.
NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices. Hongqian Chu, Jian Zhao, +2 authors, Yongsheng Mi, Zhenghan Di, Lele Li. less Nat Commun, 2019 Jun 30; 10(1). PMID: 31253798 Free PMC article.
Cancer Cell-targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Coculture Model. Eric M Kercher, Shubhankar Nath, Imran Rizvi, Bryan Q Spring. Photochem Photobiol, 2019 Aug 20; 96(2). PMID: 31424560 Free PMC article.
Cytotoxic Chemotherapy as an Immune Stimulus: A Molecular Perspective on Turning Up the Immunological Heat on Cancer. James W Opzoomer, Dominika Sosnowska, +2 authors, Joanne E Anstee, James F Spicer, James N Arnold. less Front Immunol, 2019 Aug 06; 10. PMID: 31379850 Free PMC article. Review.
Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin. Yuko Nishinaga, Kazuhide Sato, +15 authors, Yoshinori Hasegawa. less Cells, 2020 Apr 25; 9(4). PMID: 32326079 Free PMC article.
The Effect of Antibody Fragments on CD25 Targeted Regulatory T Cell Near-Infrared Photoimmunotherapy. Ryuhei Okada, Yasuhiro Maruoka, +5 authors, Hisataka Kobayashi. less Bioconjug Chem, 2019 Sep 10; 30(10). PMID: 31498995 Free PMC article.
Near-Infrared Photoimmunotherapy: Photoactivatable Antibody-Drug Conjugates (ADCs). Hisataka Kobayashi, Gary L Griffiths, Peter L Choyke. Bioconjug Chem, 2019 Sep 04; 31(1). PMID: 31479610 Free PMC article. Review.
Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy. Kazuhide Sato, Kanta Ando, +12 authors, Hisataka Kobayashi. less ACS Cent Sci, 2018 Dec 18; 4(11). PMID: 30555909 Free PMC article.
Turning the Tide Against Regulatory T Cells. SeongJun Han, Aras Toker, Zhe Qi Liu, Pamela S Ohashi. Front Oncol, 2019 May 07; 9. PMID: 31058083 Free PMC article. Review.
CD146-Targeted Multimodal Image-Guided Photoimmunotherapy of Melanoma. Weijun Wei, Dawei Jiang, +6 authors, Weibo Cai. less Adv Sci (Weinh), 2019 May 09; 6(9). PMID: 31065511 Free PMC article.
Immunomodulatory Nanosystems. Xiangru Feng, Weiguo Xu, +3 authors, Xuesi Chen. less Adv Sci (Weinh), 2019 Sep 12; 6(17). PMID: 31508270 Free PMC article. Highly Cited. Review.
CD25-targeted antibody-drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity. Francesca Zammarchi, Karin Havenith, +3 authors, Patrick H van Berkel. less J Immunother Cancer, 2020 Sep 12; 8(2). PMID: 32912922 Free PMC article.
Immunomodulatory activity of IR700-labelled affibody targeting HER2. Justyna Mączyńska, Chiara Da Pieve, +5 authors, Gabriela Kramer-Marek. less Cell Death Dis, 2020 Oct 22; 11(10). PMID: 33082328 Free PMC article.
Nano-Enhanced Cancer Immunotherapy: Immunology Encounters Nanotechnology. Ernesto Bockamp, Sebastian Rosigkeit, Dominik Siegl, Detlef Schuppan. Cells, 2020 Sep 19; 9(9). PMID: 32942725 Free PMC article. Review.
Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions. Guoming Zeng, Libo Jin, +9 authors, Da Sun. less Cancer Manag Res, 2020 Oct 30; 12. PMID: 33116895 Free PMC article. Review.
Current trends in pyrrole and porphyrin-derived nanoscale materials for biomedical applications. Parinaz Fathi, Dipanjan Pan. Nanomedicine (Lond), 2020 Sep 26; 15(25). PMID: 32975469 Free PMC article. Review.
Fractionated photothermal therapy in a murine tumor model: comparison with single dose. Marina Simón, Kamilla Norregaard, +2 authors, Andreas Kjaer. less Int J Nanomedicine, 2019 Aug 15; 14. PMID: 31409993 Free PMC article.
Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity. Hisataka Kobayashi, Aki Furusawa, Adrian Rosenberg, Peter L Choyke. Int Immunol, 2020 Jun 05; 33(1). PMID: 32496557 Free PMC article.
Nanoparticles as Smart Carriers for Enhanced Cancer Immunotherapy. Neelam Thakur, Saloni Thakur, +2 authors, Sharmistha Chatterjee, Joydeep Das, Parames C Sil. less Front Chem, 2021 Jan 08; 8. PMID: 33409265 Free PMC article. Review.
Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease. Qi Shen, Lei Liu, Xiaotong Gu, Da Xing. Aging Cell, 2020 Dec 19; 20(1). PMID: 33336891 Free PMC article.
Cancer photo-immunotherapy: from bench to bedside. Miao Wang, Jie Rao, +6 authors, Feifan Zhou. less Theranostics, 2021 Jan 28; 11(5). PMID: 33500721 Free PMC article. Review.
Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer. Yuyan Jiang, Jiaguo Huang, Cheng Xu, Kanyi Pu. Nat Commun, 2021 Feb 04; 12(1). PMID: 33531498 Free PMC article.
Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment. Waleska K Martins, Renata Belotto, +6 authors, Tayana M Tsubone. less Front Oncol, 2021 Feb 09; 10. PMID: 33552982 Free PMC article. Review.
Modulation of regulatory T cell function and stability by co-inhibitory receptors. Liliana E Lucca, Margarita Dominguez-Villar. Nat Rev Immunol, 2020 Apr 10; 20(11). PMID: 32269380 Review.
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors. Mukaddes Izci, Christy Maksoudian, Bella B Manshian, Stefaan J Soenen. Chem Rev, 2021 Jan 16; 121(3). PMID: 33445874 Free PMC article. Review.
The Impact of Tregs on the Anticancer Immunity and the Efficacy of Immune Checkpoint Inhibitor Therapies. Jose M González-Navajas, Dengxia Denise Fan, +4 authors, Jongdae Lee. less Front Immunol, 2021 Mar 16; 12. PMID: 33717139 Free PMC article. Review.
An Infrared Dye-Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma. Rhonda C Kines, Isabella Varsavsky, +10 authors, John T Schiller. less Mol Cancer Ther, 2017 Dec 16; 17(2). PMID: 29242243 Free PMC article.
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials. Ryuhei Okada, Aki Furusawa, +8 authors, Hisataka Kobayashi. less EBioMedicine, 2021 May 03; 67. PMID: 33933782 Free PMC article.
Local Depletion of Immune Checkpoint Ligand CTLA4 Expressing Cells in Tumor Beds Enhances Antitumor Host Immunity. Ryuhei Okada, Takuya Kato, +4 authors, Hisataka Kobayashi. less Adv Ther (Weinh), 2021 May 18; 4(5). PMID: 33997271 Free PMC article.
Near-infrared photoimmunotherapy targeting GPR87: Development of a humanised anti-GPR87 mAb and therapeutic efficacy on a lung cancer mouse model. Hirotoshi Yasui, Yuko Nishinaga, +9 authors, Kazuhide Sato. less EBioMedicine, 2021 May 17; 67. PMID: 33993055 Free PMC article.
Nanotechnology synergized immunoengineering for cancer. Deepak S Chauhan, Anupam Dhasmana, +6 authors, Murali M Yallapu. less Eur J Pharm Biopharm, 2021 Mar 29; 163. PMID: 33774162 Free PMC article. Review.
Rapid Depletion of Intratumoral Regulatory T Cells Induces Synchronized CD8 T- and NK-cell Activation and IFNγ-Dependent Tumor Vessel Regression. Yutaka Kurebayashi, Colleen P Olkowski, +7 authors, Noriko Sato. less Cancer Res, 2021 Feb 13; 81(11). PMID: 33574087 Free PMC article.
Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy. Takuya Kato, Hiroaki Wakiyama, +2 authors, Aki Furusawa, Peter L Choyke, Hisataka Kobayashi. less Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34064074 Free PMC article. Review.
Near-Infrared Photoimmunotherapy for Cancers of the Gastrointestinal Tract. Tadanobu Nagaya, Peter L Choyke, Hisataka Kobayashi. Digestion, 2020 Dec 15;. PMID: 33316807 Free PMC article. Review.
Regulatory T-Cells as an Emerging Barrier to Immune Checkpoint Inhibition in Lung Cancer. Daniel R Principe, Lauren Chiec, Nisha A Mohindra, Hidayatullah G Munshi. Front Oncol, 2021 Jun 19; 11. PMID: 34141625 Free PMC article. Review.
Expanding the application of cancer near-infrared photoimmunotherapy. Hisataka Kobayashi. EBioMedicine, 2021 Jun 17; 68. PMID: 34134087 Free PMC article.
Near infrared photoimmunotherapy for cancers: A translational perspective. Yasuhiro Maruoka, Hiroaki Wakiyama, Peter L Choyke, Hisataka Kobayashi. EBioMedicine, 2021 Aug 01; 70. PMID: 34332294 Free PMC article. Review.
Endoscopic near-infrared photoimmunotherapy in an orthotopic head and neck cancer model. Ryuhei Okada, Aki Furusawa, +7 authors, Hisataka Kobayashi. less Cancer Sci, 2021 Jun 09; 112(8). PMID: 34101947 Free PMC article.
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy. Laura A Huppert, Michael D Green, +4 authors, James C Lee. less Cell Mol Immunol, 2021 Aug 22; 19(1). PMID: 34417572 Free PMC article. Review.
Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies. Hiroyoshi Nishikawa, Shohei Koyama. J Immunother Cancer, 2021 Aug 01; 9(7). PMID: 34330764 Free PMC article. Review.
Copper-64-Labeled Antibody Fragments for Immuno-PET/Radioimmunotherapy with Low Renal Radioactivity Levels and Amplified Tumor-Kidney Ratios. Hiroyuki Suzuki, Shota Kise, +5 authors, Tomoya Uehara. less ACS Omega, 2021 Sep 03; 6(33). PMID: 34471758 Free PMC article.
Intratumoral Photosensitizer Delivery and Photodynamic Therapy. Chen-Hua Ma, Jeffrey Yang, Jenna L Mueller, Huang-Chiao Huang. Nano Life, 2021 Sep 07; 11(2). PMID: 34484435 Free PMC article.
Near-infrared fluorescence imaging in immunotherapy. Yuanyuan Ji, Catherine Jones, +3 authors, Hak Soo Choi. less Adv Drug Deliv Rev, 2020 Jun 25; 167. PMID: 32579891 Free PMC article. Review.
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Elimination of acquired resistance to PD-1 blockade via the concurrent depletion of tumour cells and immunosuppressive cells. Gang Xue, Ziyu Wang, +6 authors, Yong Lu. less Nat Biomed Eng, 2021 Nov 03; 5(11). PMID: 34725506 Free PMC article.
Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity. Shunichi Taki, Kohei Matsuoka, +6 authors, Kazuhide Sato. less J Immunother Cancer, 2021 Nov 03; 9(11). PMID: 34725216 Free PMC article.
Targeting regulatory T cells for immunotherapy in melanoma. Lili Huang, Yeye Guo, +4 authors, Xiaowei Xu. less Mol Biomed, 2021 Nov 23; 2(1). PMID: 34806028 Free PMC article. Review.
HER2 targeting near-infrared photoimmunotherapy for a CDDP-resistant small-cell lung cancer. Kazuomi Takahashi, Shunichi Taki, +6 authors, Kazuhide Sato. less Cancer Med, 2021 Nov 04; 10(24). PMID: 34729945 Free PMC article.
Evaluation of Fluorescence Intensity and Antitumor Effect Using Real-Time Imaging in Photoimmunotherapy. Kenji Takashima, Yoshikatsu Koga, +6 authors, Tomonori Yano. less Pharmaceuticals (Basel), 2022 Feb 27; 15(2). PMID: 35215338 Free PMC article.
Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity. Yonglin Chen, Manxue Jia, +2 authors, Sharon Wang, Sherry Xu, Nanhai He. less Front Immunol, 2022 Mar 08; 13. PMID: 35251028 Free PMC article.
Nanoparticle-Mediated Photothermal Therapy Limitation in Clinical Applications Regarding Pain Management. Marzieh Salimi, Sara Mosca, +3 authors, Nicholas Stone. less Nanomaterials (Basel), 2022 Mar 27; 12(6). PMID: 35335735 Free PMC article. Review.

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