Journal Article
. 2016 Aug;375(8).
doi: 10.1056/NEJMoa1602253.

70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

Fatima Cardoso 1 Laura J van't Veer 1 Jan Bogaerts 1 Leen Slaets 1 Giuseppe Viale 1 Suzette Delaloge 1 Jean-Yves Pierga 1 Etienne Brain 1 Sylvain Causeret 1 Mauro DeLorenzi 1 Annuska M Glas 1 Vassilis Golfinopoulos 1 Theodora Goulioti 1 Susan Knox 1 Erika Matos 1 Bart Meulemans 1 Peter A Neijenhuis 1 Ulrike Nitz 1 Rodolfo Passalacqua 1 Peter Ravdin 1 Isabel T Rubio 1 Mahasti Saghatchian 1 Tineke J Smilde 1 Christos Sotiriou 1 Lisette Stork 1 Carolyn Straehle 1 Geraldine Thomas 1 Alastair M Thompson 1 Jacobus M van der Hoeven 1 Peter Vuylsteke 1 René Bernards 1 Konstantinos Tryfonidis 1 Emiel Rutgers 1 Martine Piccart 1 MINDACT Investigators  
Affiliations
  • PMID: 27557300
  •     313 citations

Abstract

Background: The 70-gene signature test (MammaPrint) has been shown to improve prediction of clinical outcome in women with early-stage breast cancer. We sought to provide prospective evidence of the clinical utility of the addition of the 70-gene signature to standard clinical-pathological criteria in selecting patients for adjuvant chemotherapy.

Methods: In this randomized, phase 3 study, we enrolled 6693 women with early-stage breast cancer and determined their genomic risk (using the 70-gene signature) and their clinical risk (using a modified version of Adjuvant! Online). Women at low clinical and genomic risk did not receive chemotherapy, whereas those at high clinical and genomic risk did receive such therapy. In patients with discordant risk results, either the genomic risk or the clinical risk was used to determine the use of chemotherapy. The primary goal was to assess whether, among patients with high-risk clinical features and a low-risk gene-expression profile who did not receive chemotherapy, the lower boundary of the 95% confidence interval for the rate of 5-year survival without distant metastasis would be 92% (i.e., the noninferiority boundary) or higher.

Results: A total of 1550 patients (23.2%) were deemed to be at high clinical risk and low genomic risk. At 5 years, the rate of survival without distant metastasis in this group was 94.7% (95% confidence interval, 92.5 to 96.2) among those not receiving chemotherapy. The absolute difference in this survival rate between these patients and those who received chemotherapy was 1.5 percentage points, with the rate being lower without chemotherapy. Similar rates of survival without distant metastasis were reported in the subgroup of patients who had estrogen-receptor-positive, human epidermal growth factor receptor 2-negative, and either node-negative or node-positive disease.

Conclusions: Among women with early-stage breast cancer who were at high clinical risk and low genomic risk for recurrence, the receipt of no chemotherapy on the basis of the 70-gene signature led to a 5-year rate of survival without distant metastasis that was 1.5 percentage points lower than the rate with chemotherapy. Given these findings, approximately 46% of women with breast cancer who are at high clinical risk might not require chemotherapy. (Funded by the European Commission Sixth Framework Program and others; ClinicalTrials.gov number, NCT00433589; EudraCT number, 2005-002625-31.).

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Patient, 2018 Mar 07; 11(4). PMID: 29508356    Free PMC article.
Prognostic & predictive factors for planning adjuvant chemotherapy of early-stage breast cancer.
Onur Esbah, Berna Oksuzoglu.
Indian J Med Res, 2018 Mar 08; 146(5). PMID: 29512598    Free PMC article.
Review.
Update Breast Cancer 2018 (Part 1) - Primary Breast Cancer and Biomarkers.
Florin-Andrei Taran, Andreas Schneeweiss, +19 authors, Florian Schütz.
Geburtshilfe Frauenheilkd, 2018 Mar 27; 78(3). PMID: 29576629    Free PMC article.
Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer.
Shigeo Yamaguchi, Shin Takahashi, +8 authors, Shunsuke Kato.
Oncotarget, 2018 Mar 28; 9(18). PMID: 29581837    Free PMC article.
Identification of methylation sites and signature genes with prognostic value for luminal breast cancer.
Bin Xiao, Lidan Chen, +11 authors, Linhai Li.
BMC Cancer, 2018 Apr 13; 18(1). PMID: 29642861    Free PMC article.
Practice patterns and outcomes for patients with node-negative hormone receptor-positive breast cancer and intermediate 21-gene Recurrence Scores.
Jonathan Chen, Xian Wu, +2 authors, Himanshu Nagar.
Breast Cancer Res, 2018 Apr 18; 20(1). PMID: 29661221    Free PMC article.
Integration of Clinical Variables for the Prediction of Late Distant Recurrence in Patients With Estrogen Receptor-Positive Breast Cancer Treated With 5 Years of Endocrine Therapy: CTS5.
Mitch Dowsett, Ivana Sestak, +5 authors, Jack Cuzick.
J Clin Oncol, 2018 Apr 21; 36(19). PMID: 29676944    Free PMC article.
DNA Methylation Signatures Predicting Bevacizumab Efficacy in Metastatic Breast Cancer.
Simon Peter Gampenrieder, Gabriel Rinnerthaler, +8 authors, Richard Greil.
Theranostics, 2018 May 04; 8(8). PMID: 29721079    Free PMC article.
Practical consensus recommendations on management of HR + ve early breast cancer with specific reference to genomic profiling.
S Aggarwal, A Vaid, +10 authors, D Doval.
South Asian J Cancer, 2018 May 04; 7(2). PMID: 29721472    Free PMC article.
Contralateral parenchymal enhancement on dynamic contrast-enhanced MRI reproduces as a biomarker of survival in ER-positive/HER2-negative breast cancer patients.
Bas H M van der Velden, Elizabeth J Sutton, +3 authors, Kenneth G A Gilhuijs.
Eur Radiol, 2018 May 08; 28(11). PMID: 29736850    Free PMC article.
Anthracycline Use for Early Stage Breast Cancer in the Modern Era: a Review.
Sakshi Jasra, Jesus Anampa.
Curr Treat Options Oncol, 2018 May 13; 19(6). PMID: 29752560
Review.
Conventional Pathology Versus Gene Signatures for Assessing Luminal A and B Type Breast Cancers: Results of a Prospective Cohort Study.
Julia E C van Steenhoven, Anne Kuijer, +12 authors, Thijs van Dalen.
Genes (Basel), 2018 May 19; 9(5). PMID: 29772837    Free PMC article.
Gene expression profiling in prognosis of distant recurrence in HR-positive and HER2-negative breast cancer patients.
Tzu-Ting Huang, Nicolas Pennarun, +3 authors, Skye Hung-Chun Cheng.
Oncotarget, 2018 May 26; 9(33). PMID: 29796180    Free PMC article.
Prognostic gene expression assays in breast cancer: are two better than one?
Joseph A Sparano.
NPJ Breast Cancer, 2018 May 31; 4. PMID: 29845110    Free PMC article.
The PROMISe to increase precision in adjuvant therapy for early breast cancer: To "Type" or to "Print"?
Fatima Cardoso, Giuseppe Curigliano.
NPJ Breast Cancer, 2018 May 31; 4. PMID: 29845111    Free PMC article.
Patient Similarity Networks for Precision Medicine.
Shraddha Pai, Gary D Bader.
J Mol Biol, 2018 Jun 04; 430(18 Pt A). PMID: 29860027    Free PMC article.
Review.
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge.
N Engl J Med, 2018 Jun 05; 379(2). PMID: 29860917    Free PMC article.
Highly Cited.
A nomogram to predict adjuvant chemotherapy recommendation in breast cancer patients with intermediate recurrence score.
Feilin Qu, Xiaosong Chen, +10 authors, Kunwei Shen.
Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861607    Free PMC article.
Addressing the challenges of applying precision oncology.
Seung Ho Shin, Ann M Bode, Zigang Dong.
NPJ Precis Oncol, 2018 Jun 07; 1(1). PMID: 29872710    Free PMC article.
Review.
A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data.
Gaurav Pandey, Om P Pandey, +6 authors, Supinda Bunyavanich.
Sci Rep, 2018 Jun 13; 8(1). PMID: 29891868    Free PMC article.
Clinical application and utility of genomic assays in early-stage breast cancer: key lessons learned to date.
S K L Chia.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910655    Free PMC article.
Review.
Overexpression of topoisomerase II alpha protein is a factor for poor prognosis in patients with luminal B breast cancer.
Hideo Shigematsu, Shinji Ozaki, +7 authors, Kiyomi Taniyama.
Oncotarget, 2018 Jun 22; 9(42). PMID: 29928479    Free PMC article.
Whole blood transcriptome analysis in amyotrophic lateral sclerosis: A biomarker study.
Wouter van Rheenen, Frank P Diekstra, +9 authors, Leonard H van den Berg.
PLoS One, 2018 Jun 26; 13(6). PMID: 29939990    Free PMC article.
Should age impact breast cancer management in young women? Fine tuning of treatment guidelines.
Matteo B Suter, Olivia Pagani.
Ther Adv Med Oncol, 2018 Jul 07; 10. PMID: 29977348    Free PMC article.
Review.
Personalizing Radiation Treatment Delivery in the Management of Breast Cancer.
Kamran A Ahmed, G Daniel Grass, +7 authors, Roberto Diaz.
Int J Breast Cancer, 2018 Jul 10; 2018. PMID: 29984003    Free PMC article.
Review.
hERG1 channel expression associates with molecular subtypes and prognosis in breast cancer.
Jessica Iorio, Icro Meattini, +10 authors, Elena Lastraioli.
Cancer Cell Int, 2018 Jul 14; 18. PMID: 30002601    Free PMC article.
Integrated Analysis of RNA and DNA from the Phase III Trial CALGB 40601 Identifies Predictors of Response to Trastuzumab-Based Neoadjuvant Chemotherapy in HER2-Positive Breast Cancer.
Maki Tanioka, Cheng Fan, +18 authors, Charles M Perou.
Clin Cancer Res, 2018 Jul 25; 24(21). PMID: 30037817    Free PMC article.
Predicting treatment benefit in multiple myeloma through simulation of alternative treatment effects.
Joske Ubels, Pieter Sonneveld, +3 authors, Jeroen de Ridder.
Nat Commun, 2018 Jul 29; 9(1). PMID: 30054467    Free PMC article.
Using Probability for Pathological Complete Response (pCR) as a Decision Support Marker for Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer Patients - a Survey Among Physicians.
Paul Gass, Michael Untch, +18 authors, Naiba Nabieva.
Geburtshilfe Frauenheilkd, 2018 Jul 31; 78(7). PMID: 30057427    Free PMC article.
Adjuvant Anthracyclines in Breast Cancer: What Is Their Role?
Ami N Shah, William J Gradishar.
Oncologist, 2018 Aug 19; 23(10). PMID: 30120159    Free PMC article.
Review.
From hype to reality: data science enabling personalized medicine.
Holger Fröhlich, Rudi Balling, +17 authors, Blaz Zupan.
BMC Med, 2018 Aug 28; 16(1). PMID: 30145981    Free PMC article.
Genomic Testing in the Management of Early-Stage Breast Cancer.
Sima Ehsani, Kari Braun Wisinski.
J Clin Outcomes Manag, 2017 May 01; 24(5). PMID: 30158821    Free PMC article.
Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq.
Mihriban Karaayvaz, Simona Cristea, +7 authors, Leif W Ellisen.
Nat Commun, 2018 Sep 06; 9(1). PMID: 30181541    Free PMC article.
Highly Cited.
Predictive markers of endocrine response in breast cancer.
Duniya Mosly, Arran Turnbull, +2 authors, Simon Langdon.
World J Exp Med, 2018 Sep 08; 8(1). PMID: 30191138    Free PMC article.
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers.
André Filipe Vieira, Fernando Schmitt.
Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119    Free PMC article.
Review.
[Association of circulating tumor cell status with benefit of radiotherapy and survival in early-stage breast cancer].
Marciana Nona Duma.
Strahlenther Onkol, 2018 Sep 22; 194(11). PMID: 30238419
An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA project.
Giacomo Pelizzari, Grazia Arpino, +8 authors, Fabio Puglisi.
BMC Cancer, 2018 Sep 29; 18(1). PMID: 30261866    Free PMC article.
Single-cell transcriptomes reveal the mechanism for a breast cancer prognostic gene panel.
Shengwen Calvin Li, Andres Stucky, +8 authors, Jiang F Zhong.
Oncotarget, 2018 Oct 04; 9(70). PMID: 30279960    Free PMC article.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Review.
HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX.
Jonathan Nye, David Sturgill, Rajbir Athwal, Yamini Dalal.
PLoS One, 2018 Oct 27; 13(10). PMID: 30365520    Free PMC article.
The Value of Monitoring the Behavior of Circulating Tumor Cells at the End of Endocrine Therapy in Breast Cancer Patients.
Katharina Pachmann, Stefan Schuster.
Cancers (Basel), 2018 Nov 02; 10(11). PMID: 30380648    Free PMC article.
Machine Learning With K-Means Dimensional Reduction for Predicting Survival Outcomes in Patients With Breast Cancer.
Melissa Zhao, Yushi Tang, Hyunkyung Kim, Kohei Hasegawa.
Cancer Inform, 2018 Nov 21; 17. PMID: 30455569    Free PMC article.
BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer.
Mi Jeong Kwon, Sae Byul Lee, +8 authors, Young Kee Shin.
PLoS One, 2018 Nov 22; 13(11). PMID: 30462685    Free PMC article.
Update Breast Cancer 2018 (Part 3) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer.
Achim Wöckel, Michael P Lux, +17 authors, Hans-Christian Kolberg.
Geburtshilfe Frauenheilkd, 2018 Dec 01; 78(11). PMID: 30498278    Free PMC article.
Moving Breast Cancer Therapy up a Notch.
Erik W J Mollen, Jonathan Ient, +4 authors, Marc A G G Vooijs.
Front Oncol, 2018 Dec 06; 8. PMID: 30515368    Free PMC article.
Review.
Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, BRCA1-like status, tumor-infiltrating immune cells and survival.
Marcelo Sobral-Leite, Koen Van de Vijver, +21 authors, Marjanka K Schmidt.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524905    Free PMC article.
Decentralized Learning Framework of Meta-Survival Analysis for Developing Robust Prognostic Signatures.
Yi Cui, Bailiang Li, Ruijiang Li.
JCO Clin Cancer Inform, 2017 Nov 01; 1. PMID: 30657395    Free PMC article.
Whole genome sequencing of breast cancer.
Maria Rossing, Claus Storgaard Sørensen, Bent Ejlertsen, Finn Cilius Nielsen.
APMIS, 2019 Jan 29; 127(5). PMID: 30689231    Free PMC article.
Review.
Adjuvant Systemic Treatment of Premenopausal Women With Hormone Receptor-Positive Early Breast Cancer: Lights and Shadows.
Meredith M Regan, Gini F Fleming, +2 authors, Olivia Pagani.
J Clin Oncol, 2019 Feb 28; 37(11). PMID: 30811287    Free PMC article.
Evaluation of the Incorporation of Recurrence Score into the American Joint Committee on Cancer Eighth Edition Staging System in Patients with T1-2N0M0, Estrogen Receptor-Positive, Human Epidermal Growth Receptor 2-Negative Invasive Breast Cancer: A Population-Based Analysis.
Shuning Ding, Jiayi Wu, +6 authors, Li Zhu.
Oncologist, 2019 Apr 26; 24(11). PMID: 31019021    Free PMC article.
From latency to overt bone metastasis in breast cancer: potential for treatment and prevention.
Fernando Salvador, Alicia Llorente, Roger R Gomis.
J Pathol, 2019 May 17; 249(1). PMID: 31095738    Free PMC article.
Review.
Impact of 21-Gene Breast Cancer Assay on Treatment Decision for Patients with T1-T3, N0-N1, Estrogen Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Breast Cancer: Final Results of the Prospective Multicenter ROXANE Study.
Maria Vittoria Dieci, Valentina Guarneri, +16 authors, Veneto Oncology Network.
Oncologist, 2019 Jun 04; 24(11). PMID: 31152079    Free PMC article.
Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial.
Hyman B Muss, Mei-Yin C Polley, +25 authors, Lisa Carey.
J Clin Oncol, 2019 Jul 25; 37(26). PMID: 31339827    Free PMC article.
Artificial intelligence in digital pathology - new tools for diagnosis and precision oncology.
Kaustav Bera, Kurt A Schalper, +2 authors, Anant Madabhushi.
Nat Rev Clin Oncol, 2019 Aug 11; 16(11). PMID: 31399699    Free PMC article.
Highly Cited. Review.
Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer.
Christine Lundgren, Pär-Ola Bendahl, +15 authors, Maria Ekholm.
Breast Cancer Res Treat, 2019 Aug 23; 178(2). PMID: 31432367    Free PMC article.
Panoptic View of Prognostic Models for Personalized Breast Cancer Management.
Geetanjali Saini, Karuna Mittal, +3 authors, Ritu Aneja.
Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500225    Free PMC article.
Review.
Multigene expression signatures in early hormone receptor positive HER 2 negative breast cancer.
Tanja Ovcaricek, Iztok Takac, Erika Matos.
Radiol Oncol, 2019 Sep 26; 53(3). PMID: 31553709    Free PMC article.
Review.
Risk of Hematologic Malignant Neoplasms after Postoperative Treatment of Breast Cancer.
Marie Joelle Jabagi, Anthony Goncalves, +3 authors, Rosemary Dray-Spira.
Cancers (Basel), 2019 Oct 02; 11(10). PMID: 31569513    Free PMC article.
Potential Benefits of Neoadjuvant Chemotherapy in Clinically Node-Positive Luminal Subtype- Breast Cancer.
Hyung Suk Kim, Tae Kyung Yoo, Woo Chan Park, Byung Joo Chae.
J Breast Cancer, 2019 Oct 11; 22(3). PMID: 31598341    Free PMC article.
Impact of Nuclear Oestrogen Receptor Beta Expression in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.
Florian Heitz, Sherko Kümmel, +9 authors, Sibylle Loibl.
Geburtshilfe Frauenheilkd, 2019 Oct 28; 79(10). PMID: 31656321    Free PMC article.
Tumor-Infiltrating Immune Cells Act as a Marker for Prognosis in Colorectal Cancer.
Lele Ye, Teming Zhang, +12 authors, Xiangyang Xue.
Front Immunol, 2019 Nov 05; 10. PMID: 31681276    Free PMC article.
St. Gallen/Vienna 2019: A Brief Summary of the Consensus Discussion on the Optimal Primary Breast Cancer Treatment.
Marija Balic, Christoph Thomssen, +2 authors, Nadia Harbeck.
Breast Care (Basel), 2019 Dec 05; 14(2). PMID: 31798382    Free PMC article.
Review.
Treatment of Early Breast Cancer Patients: Evidence, Controversies, Consensus: Focusing on Systemic Therapy - German Experts' Opinions for the 16th International St. Gallen Consensus Conference (Vienna 2019).
Diana Lüftner, Ingo Bauerfeind, +21 authors, Marc Thill.
Breast Care (Basel), 2019 Dec 05; 14(5). PMID: 31798392    Free PMC article.
Review.
Decision of Adjuvant Systemic Treatment in HR+ HER2- Early Invasive Breast Cancer: Which Biomarkers Could Help?
Marie Alexandre, Aurélie Maran-Gonzalez, +6 authors, Séverine Guiu.
Cancer Manag Res, 2019 Dec 19; 11. PMID: 31849525    Free PMC article.
Review.
Significant inter- and intra-laboratory variation in grading of invasive breast cancer: A nationwide study of 33,043 patients in the Netherlands.
Carmen van Dooijeweert, Paul J van Diest, +4 authors, Ivette A G Deckers.
Int J Cancer, 2019 Apr 13; 146(3). PMID: 30977119    Free PMC article.
PAC-5 Gene Expression Signature for Predicting Prognosis of Patients with Pancreatic Adenocarcinoma.
Jieun Kim, Yong Hwa Jo, +9 authors, Sung Soo Kim.
Cancers (Basel), 2019 Nov 11; 11(11). PMID: 31703415    Free PMC article.
ASO Author Reflections: The Changing Role of Gene Expression Profiling in ER+/HER2- Breast Cancer.
Julia E C van Steenhoven, T van Dalen.
Ann Surg Oncol, 2019 Oct 28; 26(Suppl 3). PMID: 31650304    Free PMC article.
Decentralization of Next-Generation RNA Sequencing-Based MammaPrint® and BluePrint® Kit at University Hospitals Leuven and Curie Institute Paris.
Laurence Slembrouck, Lauren Darrigues, +31 authors, Giuseppe Floris.
Transl Oncol, 2019 Sep 13; 12(12). PMID: 31513983    Free PMC article.
Breast Cancer Index and prediction of benefit from extended endocrine therapy in breast cancer patients treated in the Adjuvant Tamoxifen-To Offer More? (aTTom) trial.
J M S Bartlett, D C Sgroi, +8 authors, D W Rea.
Ann Oncol, 2019 Sep 11; 30(11). PMID: 31504126    Free PMC article.
A Robust Gene Expression Prognostic Signature for Overall Survival in High-Grade Serous Ovarian Cancer.
Yue Zhao, Shao-Min Yang, +6 authors, Bo Hang.
J Oncol, 2019 Dec 31; 2019. PMID: 31885574    Free PMC article.
A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer.
Vincent T Wu, Boris Kiriazov, +13 authors, Ronald J Weigel.
Mol Cancer Res, 2019 Oct 18; 18(1). PMID: 31619506    Free PMC article.
Evaluation of the predictive ability of ultrasound-based assessment of breast cancer using BI-RADS natural language reporting against commercial transcriptome-based tests.
Neema Jamshidii, Jason Chang, +3 authors, Michael D Kuo.
PLoS One, 2020 Jan 11; 15(1). PMID: 31923222    Free PMC article.
Expression of miR-221 and miR-489 in breast cancer patients and their relationship with prognosis.
Fanfan Li.
Oncol Lett, 2020 Jan 23; 19(2). PMID: 31966077    Free PMC article.
Precision Medicine: From "Omics" to Economics towards Data-Driven Healthcare - Time for European Transformation.
Denis Lacombe, Lifang Liu, Françoise Meunier, Vassilis Golfinopoulos.
Biomed Hub, 2017 Nov 21; 2(Suppl 1). PMID: 31988951    Free PMC article.
Review.
MammaPrint guides treatment decisions in breast Cancer: results of the IMPACt trial.
Hatem Soliman, Varsha Shah, +11 authors, William Audeh.
BMC Cancer, 2020 Feb 02; 20(1). PMID: 32005181    Free PMC article.
Prognostic DNA methylation markers for hormone receptor breast cancer: a systematic review.
Tim C de Ruijter, Frank van der Heide, +3 authors, Vivianne C G Heijnen.
Breast Cancer Res, 2020 Feb 02; 22(1). PMID: 32005275    Free PMC article.
Systematic Review.
Clinicopathologic analysis of 722 breast cancer patients who met the inclusion criteria of the TAILORx trial.
Hong-Yu Xiang, Yin-Hua Liu, +7 authors, Qian Liu.
Chin Med J (Engl), 2019 Dec 07; 132(24). PMID: 31809316    Free PMC article.
Association Between 21-Gene Assay Recurrence Score and Locoregional Recurrence Rates in Patients With Node-Positive Breast Cancer.
Wendy A Woodward, William E Barlow, +15 authors, Kathy S Albain.
JAMA Oncol, 2020 Jan 10; 6(4). PMID: 31917424    Free PMC article.
Cholangiocarcinoma: anatomical location-dependent clinical, prognostic, and genetic disparities.
Hualian Hang, Seogsong Jeong, +4 authors, Qiang Xia.
Ann Transl Med, 2020 Feb 12; 7(23). PMID: 32042760    Free PMC article.
Evaluation of the 12-Gene Molecular Score and the 21-Gene Recurrence Score as Predictors of Response to Neo-adjuvant Chemotherapy in Estrogen Receptor-Positive, HER2-Negative Breast Cancer.
Hatem Soliman, Susanne Wagner, +9 authors, William Gradishar.
Ann Surg Oncol, 2020 Jan 08; 27(3). PMID: 31907749    Free PMC article.
Spatially multiplexed RNA in situ hybridization to reveal tumor heterogeneity.
Lena Voith von Voithenberg, Anna Fomitcheva Khartchenko, +2 authors, Govind V Kaigala.
Nucleic Acids Res, 2019 Dec 20; 48(3). PMID: 31853536    Free PMC article.
Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge.
N Engl J Med, 2019 Jun 04; 380(25). PMID: 31157962    Free PMC article.
Highly Cited.
Prognostic Impact of the 21-Gene Recurrence Score Assay Among Young Women With Node-Negative and Node-Positive ER-Positive/HER2-Negative Breast Cancer.
Philip D Poorvu, Shari I Gelber, +12 authors, Ann H Partridge.
J Clin Oncol, 2019 Dec 07; 38(7). PMID: 31809240    Free PMC article.
Use and Impact of the 21-Gene Recurrence Score in Relation to the Clinical Risk of Developing Metastases in Early Breast Cancer Patients in the Netherlands.
Kay Schreuder, Anne Kuijer, +2 authors, Sabine Siesling.
Public Health Genomics, 2019 Jan 17; 21(1-2). PMID: 30650410    Free PMC article.
MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer.
Begoña Alday-Parejo, François Richard, +5 authors, Curzio Rüegg.
Cancers (Basel), 2020 Jan 23; 12(1). PMID: 31963297    Free PMC article.
MetaGxData: Clinically Annotated Breast, Ovarian and Pancreatic Cancer Datasets and their Use in Generating a Multi-Cancer Gene Signature.
Deena M A Gendoo, Michael Zon, +5 authors, Benjamin Haibe-Kains.
Sci Rep, 2019 Jun 21; 9(1). PMID: 31217513    Free PMC article.
Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series.
Johan Vallon-Christersson, Jari Häkkinen, +12 authors, Johan Staaf.
Sci Rep, 2019 Aug 23; 9(1). PMID: 31434940    Free PMC article.
Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease.
Kelli L VanDussen, Aleksandar Stojmirović, +10 authors, Thaddeus S Stappenbeck.
Gastroenterology, 2018 May 22; 155(3). PMID: 29782846    Free PMC article.
The Prosigna 50-gene profile and responsiveness to adjuvant anthracycline-based chemotherapy in high-risk breast cancer patients.
Maj-Britt Jensen, Anne-Vibeke Lænkholm, +9 authors, Bent Ejlertsen.
NPJ Breast Cancer, 2020 Mar 07; 6. PMID: 32140564    Free PMC article.
RNA-seq of newly diagnosed patients in the PADIMAC study leads to a bortezomib/lenalidomide decision signature.
Michael A Chapman, Jonathan Sive, +27 authors, Kwee Yong.
Blood, 2018 Sep 06; 132(20). PMID: 30181174    Free PMC article.
Implications for Breast Cancer Restaging Based on the 8th Edition AJCC Staging Manual.
Jennifer K Plichta, Yi Ren, +5 authors, E Shelley Hwang.
Ann Surg, 2018 Oct 13; 271(1). PMID: 30312199    Free PMC article.
Community clinical practice patterns and mortality in patients with intermediate oncotype DX recurrence scores: Who benefits from chemotherapy?
Abiola F Ibraheem, David J Press, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2018 Nov 06; 125(2). PMID: 30387876    Free PMC article.
Lymph node involvement: Positive about the role of the recurrence score in estrogen-driven breast cancer?
Kevin Kalinsky, Ruth M O'Regan.
Cancer, 2018 Nov 06; 125(2). PMID: 30387877    Free PMC article.
Seven Genes Based Novel Signature Predicts Clinical Outcome and Platinum Sensitivity of High Grade IIIc Serous Ovarian Carcinoma.
Gang Liu, Lihua Chen, +7 authors, Lei Liu.
Int J Biol Sci, 2018 Dec 27; 14(14). PMID: 30585265    Free PMC article.
Evaluation of the Incidence of Hematologic Malignant Neoplasms Among Breast Cancer Survivors in France.
Marie Joelle Jabagi, Norbert Vey, +3 authors, Rosemary Dray-Spira.
JAMA Netw Open, 2019 Jan 19; 2(1). PMID: 30657534    Free PMC article.
Development and validation of nomograms integrating immune-related genomic signatures with clinicopathologic features to improve prognosis and predictive value of triple-negative breast cancer: A gene expression-based retrospective study.
Kang Wang, Hai-Lin Li, +5 authors, Hong-Yuan Li.
Cancer Med, 2019 Jan 25; 8(2). PMID: 30677255    Free PMC article.
Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives.
Andy Dahl, Vincent Guillemot, +2 authors, Noah Zaitlen.
Genetics, 2019 Jan 30; 211(4). PMID: 30692194    Free PMC article.
A data-driven interactome of synergistic genes improves network-based cancer outcome prediction.
Amin Allahyar, Joske Ubels, Jeroen de Ridder.
PLoS Comput Biol, 2019 Feb 07; 15(2). PMID: 30726216    Free PMC article.
Pathological profiles and clinical management challenges of breast cancer emerging in young women in Indonesia: a hospital-based study.
Sumadi Lukman Anwar, Clarista Adelia Raharjo, +8 authors, Wahyu Wulaningsih.
BMC Womens Health, 2019 Feb 08; 19(1). PMID: 30728000    Free PMC article.
Clinical validation of an immunohistochemistry-based CanAssist-Breast test for distant recurrence prediction in hormone receptor-positive breast cancer patients.
Manjiri M Bakre, Charusheila Ramkumar, +10 authors, Mark D Pegram.
Cancer Med, 2019 Mar 09; 8(4). PMID: 30848103    Free PMC article.
Breast cancer quantitative proteome and proteogenomic landscape.
Henrik J Johansson, Fabio Socciarelli, +34 authors, Janne Lehtiö.
Nat Commun, 2019 Apr 10; 10(1). PMID: 30962452    Free PMC article.
Highly Cited.
A blood-based prognostic biomarker in IBD.
Daniele Biasci, James C Lee, +9 authors, Kenneth G C Smith.
Gut, 2019 Apr 29; 68(8). PMID: 31030191    Free PMC article.
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
A Matikas, T Foukakis, S Swain, J Bergh.
Ann Oncol, 2019 May 28; 30(7). PMID: 31131397    Free PMC article.
Review.
Incidence of Ductal Carcinoma In Situ in the United States, 2000-2014.
Marc D Ryser, Laura H Hendrix, +3 authors, E Shelley Hwang.
Cancer Epidemiol Biomarkers Prev, 2019 Jun 13; 28(8). PMID: 31186262    Free PMC article.
Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer.
Allison W Kurian, Kevin C Ward, +5 authors, Steven J Katz.
JAMA Oncol, 2020 Feb 07; 6(4). PMID: 32027353    Free PMC article.
Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors.
Cristina Vaghi, Anne Rodallec, +6 authors, Sébastien Benzekry.
PLoS Comput Biol, 2020 Feb 26; 16(2). PMID: 32097421    Free PMC article.
Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial.
Rita Nanda, Minetta C Liu, +41 authors, Laura J Esserman.
JAMA Oncol, 2020 Feb 14; 6(5). PMID: 32053137    Free PMC article.
Re: Expected Monetary Impact of Oncotype DX Score-Concordant Systemic Breast Cancer Therapy Based on the TAILORx Trial.
Paolo Giorgi Rossi, Eugenio Paci.
J Natl Cancer Inst, 2019 Jun 20; 112(3). PMID: 31214709    Free PMC article.
Lymphedema in survivors of breast cancer.
Lin He, Huili Qu, Qian Wu, Yuhua Song.
Oncol Lett, 2020 Mar 21; 19(3). PMID: 32194706    Free PMC article.
Review.
Decision-making of Adjuvant Chemotherapy for Breast Cancer Patients with Discordant Risk Classifications between Clinical-Pathological Factors and 21-gene Recurrence Score.
Weiqi Gao, Lin Lin, +2 authors, Kunwei Shen.
J Cancer, 2020 Mar 24; 11(9). PMID: 32201521    Free PMC article.
Performance Characteristics of the BluePrint® Breast Cancer Diagnostic Test.
Lorenza Mittempergher, Leonie Jmj Delahaye, +7 authors, Annuska M Glas. Electronic address: Annuska.Glas@agendia.com.
Transl Oncol, 2020 Mar 26; 13(4). PMID: 32208353    Free PMC article.
A Radiation Oncologist's Guide to Axillary Management in Breast Cancer: A Walk Through the Trials.
Julie K Jang, Elana R Sverdlik, Naomi R Schechter.
Curr Breast Cancer Rep, 2020 Mar 28; 11(4). PMID: 32215182    Free PMC article.
Do Internal Mammary Nodes Matter?
Abigail S Caudle, Benjamin D Smith.
Ann Surg Oncol, 2019 Jan 09; 26(4). PMID: 30617872    Free PMC article.
MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2-Positive and/or Hormone Receptor-Negative Breast Cancers in the I-SPY 2 Trial.
A Jo Chien, Debasish Tripathy, +47 authors, I-SPY 2 Consortium.
J Clin Oncol, 2020 Feb 08; 38(10). PMID: 32031889    Free PMC article.
Transfer learning with convolutional neural networks for cancer survival prediction using gene-expression data.
Guillermo López-García, José M Jerez, Leonardo Franco, Francisco J Veredas.
PLoS One, 2020 Mar 28; 15(3). PMID: 32214348    Free PMC article.
Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of Age.
Simon J Johnston, Binafsha M Syed, +8 authors, Kwok-Leung Cheung.
Cancers (Basel), 2020 Mar 22; 12(3). PMID: 32197318    Free PMC article.
Sequential analysis of transcript expression patterns improves survival prediction in multiple cancers.
Jordan Mandel, Raghunandan Avula, Edward V Prochownik.
BMC Cancer, 2020 Apr 09; 20(1). PMID: 32264880    Free PMC article.
Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer: A Health Technology Assessment.
Ontario Health (Quality).
Ont Health Technol Assess Ser, 2020 Apr 15; 20(10). PMID: 32284770    Free PMC article.
Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.
Ugo Testa, Germana Castelli, Elvira Pelosi.
Med Sci (Basel), 2020 Mar 27; 8(1). PMID: 32210163    Free PMC article.
Review.
Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT.
Olivia Pagani, Prudence A Francis, +13 authors, SOFT and TEXT Investigators and International Breast Cancer Study Group.
J Clin Oncol, 2019 Oct 17; 38(12). PMID: 31618131    Free PMC article.
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer.
Tian-Fu Li, Hui-Juan Zeng, +7 authors, Ying Lin.
Cancer Cell Int, 2020 Apr 24; 20. PMID: 32322170    Free PMC article.
Double Trouble: Contralateral Breast Cancer Risk Management in the Modern Era.
Kevin J Cheung, Nancy E Davidson.
J Natl Cancer Inst, 2019 Jan 31; 111(7). PMID: 30698728    Free PMC article.
Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations.
Ryan J O Dowling, Kevin Kalinsky, +29 authors, Pamela J Goodwin.
JNCI Cancer Spectr, 2020 Apr 28; 3(4). PMID: 32337479    Free PMC article.
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease.
Ioannis Zerdes, Emmanouil G Sifakis, +6 authors, Theodoros Foukakis.
Mol Oncol, 2020 Mar 03; 14(5). PMID: 32115850    Free PMC article.
Personalized Risk Prediction in Clinical Oncology Research: Applications and Practical Issues Using Survival Trees and Random Forests.
Chen Hu, Jon Arni Steingrimsson.
J Biopharm Stat, 2017 Oct 20; 28(2). PMID: 29048993    Free PMC article.
RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer.
Fei Chen, Yuancheng Li, +10 authors, Hongbing Shen.
J Biomed Res, 2020 Apr 20; 34(2). PMID: 32305967    Free PMC article.
Chromatin regulators mediate anthracycline sensitivity in breast cancer.
Jose A Seoane, Jacob G Kirkland, +2 authors, Christina Curtis.
Nat Med, 2019 Nov 09; 25(11). PMID: 31700186    Free PMC article.
Maximizing Breast Cancer Therapy with Awareness of Potential Treatment-Related Blood Disorders.
Henry G Kaplan, Gregory S Calip, Judith A Malmgren.
Oncologist, 2020 Feb 20; 25(5). PMID: 32073195    Free PMC article.
Review.
Commercially Available Gene Expression Assays as Predictive Tools for Adjuvant Radiotherapy? A Critical Review.
David Krug, René Baumann, +12 authors, Rolf Sauer.
Breast Care (Basel), 2020 May 14; 15(2). PMID: 32398980    Free PMC article.
Review.
Cut-Off Analysis of CTC Change under Systemic Therapy for Defining Early Therapy Response in Metastatic Breast Cancer.
Thomas M Deutsch, Stefan Stefanovic, +10 authors, Markus Wallwiener.
Cancers (Basel), 2020 Apr 30; 12(4). PMID: 32344685    Free PMC article.
Single-center versus multi-center data sets for molecular prognostic modeling: a simulation study.
Daniel Samaga, Roman Hornung, +5 authors, Kristian Unger.
Radiat Oncol, 2020 May 16; 15(1). PMID: 32410693    Free PMC article.
21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort.
J Bryan Iorgulescu, Rachel A Freedman, +2 authors, Jane E Brock.
JCO Precis Oncol, 2019 Jan 01; 3. PMID: 32457931    Free PMC article.
Strategies to Improve Recruitment to a De-escalation Trial: A Mixed-Methods Study of the OPTIMA Prelim Trial in Early Breast Cancer.
C Conefrey, J L Donovan, +18 authors, OPTIMA Prelim Study Group.
Clin Oncol (R Coll Radiol), 2020 Feb 25; 32(6). PMID: 32089356    Free PMC article.
Data-driven Sublanguage Analysis for Cancer Genomics Knowledge Modeling: Applications in Mining Oncological Genetics Information from Patients' Genetic Reports.
Yiqing Zhao, Hanzhong Yu, +4 authors, Chen Wang.
AMIA Jt Summits Transl Sci Proc, 2020 Jun 02; 2020. PMID: 32477695    Free PMC article.
Prognostic gene expression signature revealed the involvement of mutational pathways in cancer genome.
Hongde Liu, Huamei Li, +2 authors, Xiao Sun.
J Cancer, 2020 Jun 04; 11(15). PMID: 32489468    Free PMC article.
Efficacy of neoadjuvant endocrine therapy compared with neoadjuvant chemotherapy in pre-menopausal patients with oestrogen receptor-positive and HER2-negative, lymph node-positive breast cancer.
Hee Jeong Kim, Woo Chul Noh, +7 authors, Sei Hyun Ahn.
Breast Cancer Res, 2020 May 29; 22(1). PMID: 32460816    Free PMC article.
DGM-CM6: A New Model to Predict Distant Recurrence Risk in Operable Endocrine-Responsive Breast Cancer.
Lei Lei, Xiao-Jia Wang, +2 authors, Yunyun Zhou.
Front Oncol, 2020 Jun 13; 10. PMID: 32528885    Free PMC article.
Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma.
Teppei Sugano, Masayuki Yoshida, +7 authors, Tesshi Yamada.
Br J Cancer, 2020 Apr 09; 122(12). PMID: 32265507    Free PMC article.
Clinically high-risk breast cancer displays markedly discordant molecular risk predictions between the MammaPrint and EndoPredict tests.
Stephan Wenzel Jahn, Andreas Bösl, +8 authors, Farid Moinfar.
Br J Cancer, 2020 Apr 28; 122(12). PMID: 32336753    Free PMC article.
Patients' perceptions of 70-gene signature testing: commonly changing the initial inclination to undergo or forego chemotherapy and reducing decisional conflict.
Julia E C van Steenhoven, Bianca M den Dekker, +6 authors, Thijs van Dalen.
Breast Cancer Res Treat, 2020 May 21; 182(1). PMID: 32430679    Free PMC article.
EndoPredict® in early hormone receptor-positive, HER2-negative breast cancer.
K Almstedt, S Mendoza, +9 authors, M Schmidt.
Breast Cancer Res Treat, 2020 May 22; 182(1). PMID: 32436145    Free PMC article.
Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer.
Gagan Gupta, Caroline Dasom Lee, +10 authors, Amy H Tang.
Ann Breast Cancer Ther, 2020 Jun 17; 4(1). PMID: 32542231    Free PMC article.
Optimal Control Theory for Personalized Therapeutic Regimens in Oncology: Background, History, Challenges, and Opportunities.
Angela M Jarrett, Danial Faghihi, +5 authors, Thomas E Yankeelov.
J Clin Med, 2020 May 07; 9(5). PMID: 32370195    Free PMC article.
Review.
Multi-Gene Prognostic Signatures and Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy in ER-positive, HER2-negative Breast Cancer Patients.
Claudia Mazo, Stephen Barron, Catherine Mooney, William M Gallagher.
Cancers (Basel), 2020 May 07; 12(5). PMID: 32369904    Free PMC article.
Distribution of the 21-Gene Breast Recurrence Score in Patients with Primary Breast Cancer in Germany.
Vincent P Walter, Florin-Andrei Taran, +6 authors, Andreas Daniel Hartkopf.
Geburtshilfe Frauenheilkd, 2020 Jun 23; 80(6). PMID: 32565552    Free PMC article.
Systems Biology and Kidney Disease.
Jennifer A Schaub, Habib Hamidi, Lalita Subramanian, Matthias Kretzler.
Clin J Am Soc Nephrol, 2020 Jan 30; 15(5). PMID: 31992571    Free PMC article.
Weathering the Storm: Managing Older Adults with Breast Cancer Amid COVID-19 and Beyond.
Rachel A Freedman, Mina S Sedrak, +8 authors, Eric P Winer.
J Natl Cancer Inst, 2020 May 26;. PMID: 32449757    Free PMC article.
Impact of chemotherapy, radiotherapy, and endocrine therapy on sick leave in women with early-stage breast cancer during a 5-year period: a population-based cohort study.
Anna Plym, Anna L V Johansson, +4 authors, Mats Lambe.
Breast Cancer Res Treat, 2020 Jun 09; 182(3). PMID: 32506337    Free PMC article.
The concordance of treatment decision guided by OncotypeDX and the PREDICT tool in real-world early-stage breast cancer.
Daniel A Goldstein, Chen Mayer, +5 authors, Hadar Goldvaser.
Cancer Med, 2020 May 07; 9(13). PMID: 32372569    Free PMC article.
Impact of mRNA-Assessed Molecular Subtype Conversion, Intact and Apoptotic Circulating Tumor Cells on Survival of Metastatic Breast Cancer Patients: Proof of Principle.
Stefan Stefanovic, Thomas M Deutsch, +9 authors, Markus Wallwiener.
Diagnostics (Basel), 2020 Jun 10; 10(6). PMID: 32512707    Free PMC article.
Case 22-2020: A 62-Year-Old Woman with Early Breast Cancer during the Covid-19 Pandemic.
Laura M Spring, Michelle C Specht, +6 authors, Beverly Moy.
N Engl J Med, 2020 Jul 02; 383(3). PMID: 32610007    Free PMC article.
Fifteen mRNA-lncRNA expression-based signature predicted the survival of late-staged head and neck squamous cell carcinoma.
He Ren, Huaping Li, +3 authors, Liping Sun.
Biosci Rep, 2020 Jun 06; 40(7). PMID: 32500914    Free PMC article.
Variability in hospital treatment costs: a time-driven activity-based costing approach for early-stage invasive breast cancer patients.
Erin Roman, Brecht Cardoen, Jan Decloedt, Filip Roodhooft.
BMJ Open, 2020 Jul 10; 10(7). PMID: 32641325    Free PMC article.
Nodal positivity decreases with age in women with early-stage, hormone receptor-positive breast cancer.
Stephanie M Downs-Canner, Charles E Gaber, +4 authors, David W Ollila.
Cancer, 2019 Dec 21; 126(6). PMID: 31860136    Free PMC article.
Management of hormone receptor-positive, HER2-negative early breast cancer.
Elaine M Walsh, Karen L Smith, Vered Stearns.
Semin Oncol, 2020 Jun 18; 47(4). PMID: 32546323    Free PMC article.
Review.
Prognostic potential of automated Ki67 evaluation in breast cancer: different hot spot definitions versus true global score.
Stephanie Robertson, Balazs Acs, Michael Lippert, Johan Hartman.
Breast Cancer Res Treat, 2020 Jun 24; 183(1). PMID: 32572716    Free PMC article.
Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial.
I-SPY2 Trial Consortium, Douglas Yee, +77 authors, Donald A Berry.
JAMA Oncol, 2020 Jul 24; 6(9). PMID: 32701140    Free PMC article.
Breast cancer surveillance for BRCA1/2 mutation carriers - is "early detection" early enough?
Rinat Bernstein-Molho, Bella Kaufman, +5 authors, Eitan Friedman.
Breast, 2019 Nov 25; 49. PMID: 31760168    Free PMC article.
Decision of adjuvant chemotherapy in intermediate risk luminal breast cancer patients: A prospective multicenter trial assessing the clinical and psychological impact of EndoPredict® (EpClin) use (UCBG 2-14).
Frédérique Penault-Llorca, Fabrice Kwiatkowski, +18 authors, Suzette Delaloge.
Breast, 2019 Dec 04; 49. PMID: 31790959    Free PMC article.
Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution's Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer.
Angela Fischer Maranta, Simon Broder, +4 authors, Thomas Ruhstaller.
Breast, 2020 Apr 18; 51. PMID: 32302928    Free PMC article.
Estimation of historical control rate for a single arm de-escalation study - Application to the POSITIVE trial.
Zhuoxin Sun, Samuel M Niman, +9 authors, POSITIVE Steering Committee.
Breast, 2020 Jun 15; 53. PMID: 32535486    Free PMC article.
AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2019.
Nina Ditsch, Michael Untch, +42 authors, Achim Wöckel.
Breast Care (Basel), 2019 Sep 29; 14(4). PMID: 31558897    Free PMC article.
Review.
Overview of Breast Cancer and Implications of Overtreatment of Early-Stage Breast Cancer: An Indian Perspective.
Gouri Shankar Bhattacharyya, Dinesh C Doval, +3 authors, S P Somashekhar.
JCO Glob Oncol, 2020 Jun 09; 6. PMID: 32511068    Free PMC article.
Establishment of prognostic nomograms based on skeletal muscle index and serum biomarker in breast cancer patients receiving radiotherapy.
Xin Hua, Xin Huang, +5 authors, Zhong-Yu Yuan.
Clin Transl Med, 2020 Jul 01; 10(2). PMID: 32602615    Free PMC article.
The underreporting of phase III chemo-therapeutic clinical trial data of older patients with cancer: A systematic review.
Karlynn BrintzenhofeSzoc, Jessica L Krok-Schoen, +10 authors, Armin Shahrokni.
J Geriatr Oncol, 2020 Jan 15; 11(3). PMID: 31932259    Free PMC article.
Review.
Propensity score analysis of the prognostic value of genomic assays for breast cancer in diverse populations using the National Cancer Data Base.
Abiola Ibraheem, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2020 Jun 11; 126(17). PMID: 32521056    Free PMC article.
The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database.
In Sil Choi, Jiwoong Jung, +5 authors, Ki-Tae Hwang.
Cancers (Basel), 2020 Jul 12; 12(7). PMID: 32650374    Free PMC article.
Controlling technical variation amongst 6693 patient microarrays of the randomized MINDACT trial.
Laurent Jacob, Anke Witteveen, +17 authors, Annuska Glas.
Commun Biol, 2020 Jul 29; 3(1). PMID: 32719399    Free PMC article.
Personalised medicine and the decision to withhold chemotherapy in early breast cancer with intermediate risk of recurrence - a systematic review and meta-analysis.
Susanna M Wallerstedt, Astrid Nilsson Ek, +3 authors, Barbro Linderholm.
Eur J Clin Pharmacol, 2020 Jun 07; 76(9). PMID: 32504183    Free PMC article.
Review.
Decreased expression of the thyroid hormone-inactivating enzyme type 3 deiodinase is associated with lower survival rates in breast cancer.
Iuri Martin Goemann, Vicente Rodrigues Marczyk, +3 authors, Ana Luiza Maia.
Sci Rep, 2020 Aug 19; 10(1). PMID: 32807826    Free PMC article.
Prognostic significance of residual nodal disease after neoadjuvant endocrine therapy for hormone receptor-positive breast cancer.
Olga Kantor, Stephanie Wong, +3 authors, Tari A King.
NPJ Breast Cancer, 2020 Aug 22; 6. PMID: 32821803    Free PMC article.
Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference.
Justine R Smith, Jacob Pe'er, +22 authors, Joan M O'Brien.
Transl Vis Sci Technol, 2019 Jan 18; 8(1). PMID: 30652059    Free PMC article.
Identification of a Six-lncRNA Signature With Prognostic Value for Breast Cancer Patients.
Erjie Zhao, Yujia Lan, +5 authors, Jing Hu.
Front Genet, 2020 Aug 28; 11. PMID: 32849766    Free PMC article.
Clinical Value of RNA Sequencing-Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network-Breast Initiative.
Christian Brueffer, Johan Vallon-Christersson, +13 authors, Lao H Saal.
JCO Precis Oncol, 2018 Mar 09; 2. PMID: 32913985    Free PMC article.
Expression patterns of small numbers of transcripts from functionally-related pathways predict survival in multiple cancers.
Jordan Mandel, Huabo Wang, +5 authors, Edward V Prochownik.
BMC Cancer, 2019 Jul 14; 19(1). PMID: 31299925    Free PMC article.
Simulation modeling approaches to answer clinically relevant questions in breast cancer low-risk populations.
Ana Calin, Miguel Martin, Sara Lopez-Tarruella.
Ann Transl Med, 2019 Jan 08; 6(Suppl 1). PMID: 30613655    Free PMC article.
Profiling of Invasive Breast Carcinoma Circulating Tumour Cells-Are We Ready for the 'Liquid' Revolution?
Marcin Braun, Aleksandra Markiewicz, +2 authors, Hanna Romańska.
Cancers (Basel), 2019 Jan 30; 11(2). PMID: 30691008    Free PMC article.
Review.
Comparison of the 7th and 8th edition of American Joint Committee on Cancer (AJCC) staging systems for breast cancer patients: a Surveillance, Epidemiology and End Results (SEER) Analysis.
Nan Shao, Chuanbo Xie, +6 authors, Ying Lin.
Cancer Manag Res, 2019 Mar 14; 11. PMID: 30863154    Free PMC article.
Systematic Review of the Prognostic Role of the Immune System After Surgery of Colorectal Liver Metastases.
Joost Hof, Klaas Kok, Rolf H Sijmons, Koert P de Jong.
Front Oncol, 2019 Apr 04; 9. PMID: 30941301    Free PMC article.
Systematic Review.
A Machine Learning Approach for Identifying Gene Biomarkers Guiding the Treatment of Breast Cancer.
Ashraf Abou Tabl, Abedalrhman Alkhateeb, +2 authors, Alioune Ngom.
Front Genet, 2019 Apr 12; 10. PMID: 30972106    Free PMC article.
Identification of Prognostic Alternative Splicing Signature in Breast Carcinoma.
Dong Zhang, Yi Duan, Jinjing Cun, Qifeng Yang.
Front Genet, 2019 Apr 16; 10. PMID: 30984247    Free PMC article.
Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment.
Alex B Blair, Vincent P Groot, Jin He.
Ann Transl Med, 2019 Apr 30; 7(Suppl 1). PMID: 31032290    Free PMC article.
A Pathology-Based Combined Model to Identify PAM50 Non-luminal Intrinsic Disease in Hormone Receptor-Positive HER2-Negative Breast Cancer.
Tomás Pascual, Miguel Martin, +21 authors, Aleix Prat.
Front Oncol, 2019 May 21; 9. PMID: 31106144    Free PMC article.
Should a Multigene Signature be Used in all Luminal Early Breast Cancers.
Nawale Hajjaji, Yves Marie Robin, Jacques Bonneterre.
Front Oncol, 2019 Jun 20; 9. PMID: 31214499    Free PMC article.
BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening.
Rachel G Grashow, Vanessa Y De La Rosa, +2 authors, Ruthann A Rudel.
Comput Toxicol, 2018 Feb 01; 5. PMID: 31218268    Free PMC article.
Paradigm Shift From Halstedian Radical Mastectomy to Personalized Medicine.
Vahit Özmen.
J Breast Health, 2017 Apr 01; 13(2). PMID: 31244529    Free PMC article.
Review.
Highlights of the 16th St Gallen International Breast Cancer Conference, Vienna, Austria, 20-23 March 2019: personalised treatments for patients with early breast cancer.
Consuelo Morigi.
Ecancermedicalscience, 2019 Jul 10; 13. PMID: 31281421    Free PMC article.
31 gene expression-based signatures serve as indicators of prognosis for patients with glioma.
Zhongjun Yan, Jianlong Yang, +2 authors, Yan Hu.
Oncol Lett, 2019 Jul 11; 18(1). PMID: 31289499    Free PMC article.
Big Data Approaches for Modeling Response and Resistance to Cancer Drugs.
Peng Jiang, William R Sellers, X Shirley Liu.
Annu Rev Biomed Data Sci, 2019 Jul 26; 1. PMID: 31342013    Free PMC article.
Gene Expression Assays for Early-Stage Hormone Receptor-Positive Breast Cancer: Understanding the Differences.
Ana Tablante Nunes, Deborah E Collyar, Lyndsay N Harris.
JNCI Cancer Spectr, 2017 Dec 11; 1(1). PMID: 31360834    Free PMC article.
Review.
Dysregulation of DNA methylation patterns may identify patients with breast cancer resistant to endocrine therapy: A predictive classifier based on differentially methylated regions.
Fan Zhang, Yukun Cui.
Oncol Lett, 2019 Aug 20; 18(2). PMID: 31423189    Free PMC article.
De-escalation yes, but not at the expense of efficacy: in defense of better treatment.
Charles L Shapiro.
NPJ Breast Cancer, 2019 Aug 21; 5. PMID: 31428678    Free PMC article.
Neoadjuvant Endocrine Therapy Versus Neoadjuvant Chemotherapy in Node-Positive Invasive Lobular Carcinoma.
M J Thornton, H V Williamson, +7 authors, O M Fayanju.
Ann Surg Oncol, 2019 Jul 26; 26(10). PMID: 31342392    Free PMC article.
Does the Sequence of Anthracycline and Taxane Matter? The NeoSAMBA Trial.
José Bines, Isabele A Small, +9 authors, Martin Bonamino.
Oncologist, 2020 Jun 02;. PMID: 32476183    Free PMC article.
Luminal Breast Cancer: The Head of Janus in Breast Oncology.
Oleg Gluz.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982641    Free PMC article.
Genomic Signatures in Luminal Breast Cancer.
Julian Puppe, Tabea Seifert, +3 authors, Wolfram Malter.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982645    Free PMC article.
Review.
Future perspectives of surgical treatment of breast cancer.
Margit Riis.
Ann Med Surg (Lond), 2020 Oct 03; 59. PMID: 33005399    Free PMC article.
Do we still need breast cancer screening in the era of targeted therapies and precision medicine?
Rubina Manuela Trimboli, Paolo Giorgi Rossi, +4 authors, Francesco Sardanelli.
Insights Imaging, 2020 Sep 26; 11(1). PMID: 32975658    Free PMC article.
Review.
Assessment of tumour proliferation by use of the mitotic activity index, and Ki67 and phosphohistone H3 expression, in early-stage luminal breast cancer.
Julia E C van Steenhoven, Anne Kuijer, +4 authors, Paul J van Diest.
Histopathology, 2020 Jun 20; 77(4). PMID: 32557844    Free PMC article.
Clinical utility of genomic signatures in young breast cancer patients: a systematic review.
Cynthia Villarreal-Garza, Ana S Ferrigno, +3 authors, Hatem A Azim.
NPJ Breast Cancer, 2020 Oct 17; 6. PMID: 33062888    Free PMC article.
Review.
Inter-tumor genomic heterogeneity of breast cancers: comprehensive genomic profile of primary early breast cancers and relapses.
Caterina Fumagalli, Alberto Ranghiero, +8 authors, Massimo Barberis.
Breast Cancer Res, 2020 Oct 17; 22(1). PMID: 33059724    Free PMC article.
Management of Breast Cancer During the COVID-19 Pandemic: A Stage- and Subtype-Specific Approach.
Jennifer Y Sheng, Cesar A Santa-Maria, +18 authors, Karen L Smith.
JCO Oncol Pract, 2020 Jul 01; 16(10). PMID: 32603252    Free PMC article.
Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening.
Laura Moody, Hong Chen, Yuan-Xiang Pan.
BMC Med Genomics, 2020 Oct 23; 13(Suppl 10). PMID: 33087122    Free PMC article.
Beyond Chemotherapies: Recent Strategies in Breast Cancer Treatment.
Arthur Foulon, Pierrick Theret, Lise Rodat-Despoix, Philippe Kischel.
Cancers (Basel), 2020 Sep 20; 12(9). PMID: 32947780    Free PMC article.
Review.
Gemcitabine as adjuvant chemotherapy in patients with high-risk early breast cancer-results from the randomized phase III SUCCESS-A trial.
Amelie de Gregorio, Lothar Häberle, +22 authors, Wolfgang Janni.
Breast Cancer Res, 2020 Oct 25; 22(1). PMID: 33097092    Free PMC article.
Circulating MicroRNAs as Prognostic and Therapeutic Biomarkers in Breast Cancer Molecular Subtypes.
Veronica Zelli, Chiara Compagnoni, +7 authors, Edoardo Alesse.
J Pers Med, 2020 Aug 28; 10(3). PMID: 32842653    Free PMC article.
Review.
CORR Insights®: Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas.
Adam S Levin.
Clin Orthop Relat Res, 2020 Jun 27; 478(11). PMID: 32590452    Free PMC article.
The transition from primary colorectal cancer to isolated peritoneal malignancy is associated with an increased tumour mutational burden.
Sally Hallam, Joanne Stockton, +4 authors, Andrew D Beggs.
Sci Rep, 2020 Nov 05; 10(1). PMID: 33144643    Free PMC article.
Patient and physician factors associated with Oncotype DX and adjuvant chemotherapy utilization for breast cancer patients in New Hampshire, 2010-2016.
Thomas M Schwedhelm, Judy R Rees, +4 authors, Erika L Moen.
BMC Cancer, 2020 Sep 05; 20(1). PMID: 32883270    Free PMC article.
Landmark trials in the medical oncology management of early stage breast cancer.
Whitney Hensing, Cesar A Santa-Maria, Lindsay L Peterson, Jennifer Y Sheng.
Semin Oncol, 2020 Sep 17; 47(5). PMID: 32933761    Free PMC article.
Review.
A nuclear transport-related gene signature combined with IDH mutation and 1p/19q codeletion better predicts the prognosis of glioma patients.
Zheng Zhu, Yang Lan, +10 authors, Tao Luo.
BMC Cancer, 2020 Nov 11; 20(1). PMID: 33167941    Free PMC article.
Update Breast Cancer 2020 Part 3 - Early Breast Cancer.
Jens Huober, Andreas Schneeweiss, +16 authors, Achim Wöckel.
Geburtshilfe Frauenheilkd, 2020 Nov 12; 80(11). PMID: 33173238    Free PMC article.
Individualized Prediction of Survival by a 10-Long Non-coding RNA-Based Prognostic Model for Patients With Breast Cancer.
Xuemei Yang, Juan Li, +9 authors, Chuanxin Wang.
Front Oncol, 2020 Nov 17; 10. PMID: 33194577    Free PMC article.
How to Predict Metastasis in Luminal Breast Cancer? Current Solutions and Future Prospects.
Sylwia Tabor, Małgorzata Szostakowska-Rodzos, Anna Fabisiewicz, Ewa A Grzybowska.
Int J Mol Sci, 2020 Nov 14; 21(21). PMID: 33182512    Free PMC article.
Review.
Multidimensional Machine Learning Personalized Prognostic Model in an Early Invasive Breast Cancer Population-Based Cohort in China: Algorithm Validation Study.
Xiaorong Zhong, Ting Luo, +13 authors, Hong Zheng.
JMIR Med Inform, 2020 Nov 10; 8(11). PMID: 33164899    Free PMC article.